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Expression of Programmed Death Ligand-1 and Correlation with Clinicopathological Features and CD8 Infiltration in Breast Cancer 程序性死亡配体-1在乳腺癌中的表达及其与临床病理特征和CD8浸润的关系
Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13602
S. Salih, M. Abdelaziz, Altaf S. Mosad, Ibtihal M. Abdelhag, Elmassry Re, Nadia Eldawi
Background: Breast cancer (BC) is considered one of the most diversified types of tumors, characterized by a high mutational burden in the tumor milieu and a lack of immune cell makeup. The programmed death receptor-1 (PD -1)/programmed death ligand-1 (PD -L1) axis has been identified as a new target in the field of immunotherapy because, when activated, they worsen the future scenarios of the disease by helping tumor cells (TC) to escape immune surveillance. This study aims to investigate the expression of PD-L1 in BC tissues from Sudanese women and correlate the expression with clinicopathological features and the infiltration of CD8+T lymphocytes by immunohistochemistry (IHC). Methods: One hundred and fifty archived BC blocks were collected from the National Public Health Laboratory from January 2019 to August 2020. Data regarding age, TNM staging, grade, and hormonal status were considered. Tissue sections were examined using IHC to determine the expression of PD-L1 and CD8. Results: Among one hundred and fifty BC samples, 73 (48.7%) were TNBCs, and 77 (51.3%) were hormone-positive BCs. PDL-1 was significantly associated with BC subtypes, especially TNBCs (P = 0.001), a similar significant association was shown with CD8 infiltration (P = 0.006). None of the clinicopathological features was associated with PD-L1 expression. Conclusion: PD-L1 expression is strongly associated with TNBC’s and linked to CD8+ cells infiltration to the tumor milieu. Moreover, no correlation has been observed between the expression of PD-L1 and clinicopathological features in this study.
背景:乳腺癌(BC)被认为是最多样化的肿瘤类型之一,其特点是肿瘤环境中的高突变负担和缺乏免疫细胞组成。程序性死亡受体-1 (PD -1)/程序性死亡配体-1 (PD -L1)轴已被确定为免疫治疗领域的新靶点,因为当它们被激活时,它们通过帮助肿瘤细胞(TC)逃避免疫监视而使疾病的未来情况恶化。本研究旨在探讨PD-L1在苏丹妇女BC组织中的表达,并通过免疫组化(IHC)研究PD-L1表达与临床病理特征和CD8+T淋巴细胞浸润的关系。方法:从2019年1月至2020年8月从国家公共卫生实验室收集150个存档的BC块。考虑了年龄、TNM分期、分级和激素状态等数据。组织切片采用免疫组化法检测PD-L1和CD8的表达。结果:150例BC标本中,tnbc 73例(48.7%),激素阳性BC 77例(51.3%)。PDL-1与BC亚型,尤其是tnbc有显著相关性(P = 0.001),与CD8浸润也有类似的显著相关性(P = 0.006)。临床病理特征均与PD-L1表达无关。结论:PD-L1表达与TNBC密切相关,并与肿瘤环境中CD8+细胞的浸润有关。此外,本研究未发现PD-L1的表达与临床病理特征之间存在相关性。
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引用次数: 0
Inappropriate Prescribing of Cefixime 400 mg Every 12 Hours Dose 头孢克肟每12小时400mg处方不当
Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13609
Durr-e-Shahwar Siddiqui
This is a Letter and does not have an abstract. Please download the PDF or view the article in HTML.
这是一封信,没有摘要。请下载PDF或以HTML格式阅览文章。
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引用次数: 0
Exploring Work-related Anxiety Among Newly Graduated Nurses in the Riyadh Region 利雅得地区新毕业护士工作相关焦虑调查
Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13604
Kholoud Alrashedi, Amira Boshra
Background: Work-related anxiety among nurses has been linked to various issues, including a heavy workload, work-related conflict, a lack of resources, and stress. This research aims to explore work-related anxiety among recently graduated nurses in Saudi Arabia’s Riyadh region. Methods: A descriptive, cross-sectional, and relational research design examined work-related anxiety among newly graduated nurses. A sample of 400 nurses was recruited from five Saudi hospitals in the Riyadh region. This study used the job anxiety scale ( JAS) as a study tool. The tool is a self-rating scale of 70 items for assessing job anxiety but only 25 items were applied to this research. A self-administered questionnaire was used to gather demographic information. Results: This study revealed that there was, overall, low work-related anxiety among the nurse participants. On the one hand, age, gender, educational qualification, job experience, workplace, and work scheduling (hours per week) were found to impact work-related anxiety substantially. On the other hand, work position, nationality, unit of care, and marital status were found to play no significant role in work-related anxiety. Conclusion: The study’s findings indicate the importance of paying more attention to workplace anxiety. As anxiety may affect nurses’ ability to attend to the needs of patients in their care units, addressing it can reduce burnout and the desire to quit. Changes in work processes, care models, and leadership may be effective in creating a supportive environment that decreases stress and anxiety, promote learning, and provides patients with optimal and safe nursing care. Health policymakers and nurse managers in Saudi Arabia should develop particular intervention programs to reduce work-related anxiety among newly graduated nurses. Managers must seek techniques that help to adapt the present environment to the needs of nurses, as well as approaches that offer newly graduating nurses essential assistance, such as clinical supervision.
背景:护士的工作相关焦虑与各种问题有关,包括工作量大、工作冲突、资源缺乏和压力。本研究旨在探讨与工作相关的焦虑在沙特阿拉伯利雅得地区最近毕业的护士。方法:采用描述性、横断面和相关性研究设计对新毕业护士的工作焦虑进行调查。从利雅得地区的五家沙特医院招募了400名护士样本。本研究采用工作焦虑量表(JAS)作为研究工具。该工具是一个70项的自评量表,用于评估工作焦虑,但本研究仅应用了25项。一份自我填写的问卷被用来收集人口统计信息。结果:本研究显示,总体而言,护士参与者的工作焦虑程度较低。一方面,年龄、性别、教育程度、工作经历、工作场所和工作安排(每周工作时间)对工作相关焦虑有很大影响。另一方面,工作职位、国籍、照顾单位、婚姻状况对工作焦虑无显著影响。结论:研究结果表明,对职场焦虑给予更多关注的重要性。由于焦虑可能会影响护士在护理单位照顾病人需求的能力,解决焦虑可以减少倦怠和辞职的欲望。工作流程、护理模式和领导的改变可以有效地创造一个支持性的环境,减少压力和焦虑,促进学习,并为患者提供最佳和安全的护理。沙特阿拉伯的卫生政策制定者和护士管理者应该制定特定的干预方案,以减少新毕业护士的工作焦虑。管理人员必须寻求有助于使当前环境适应护士需求的技术,以及为刚毕业的护士提供必要帮助的方法,如临床监督。
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引用次数: 0
Chronotype, Daytime Sleepiness, and Related Factors Effects on Skipping Classroom among Medical Students in Tabuk 时间类型、日间嗜睡及相关因素对Tabuk医科学生逃课的影响
Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13601
Turki Aqahtani, A. Albalawi, J. Alotaibi, Atheer K. Alshareef, Tariq Alrasheed, H. Mirghani, Iman Mirza, Amerah Alatawi, H. Albalawi, Mohammed Sheik
Background: Lecture attendance is very critical in medical practice. Good sleep hygiene is crucial for academic performance. Therefore, this research aimed to assess the relationship between daytime sleepiness and the chronotype, and skipping the classroom. Methods: A cross-sectional study was conducted among medical Students in Tabuk from April 2022 to July 2022. Three hundred and thirty-four medical students were randomly selected. A standardized questionnaire based on the daytime sleepiness scale, morningness–eveningness questionnaire, and risk for skipping classrooms was used. The students detailed their sleeping habits for two weeks and then responded to the questionnaire distributed directly by the researchers who attended to solve any difficulties. Results: Out of the 334 students,74.7% skipped the classroom last month. The most common reason for absence was the lecturer directly reading from the slide show (72.8%), followed by late lectures (67.8%), lecturers’ presentation skills (65.6%), and lack of interest (57.9%). Daytime sleepiness was evident in 40.1% of the students and was associated with skipping lectures (Wald, 3.86, P-value, 0.049, and 95% CI, 0.19–0.91). The majority were intermediate chronotypes (66.4%), followed by evening chronotypes (24.2%) with no association with skipping classrooms. Conclusion: Skipping lectures is common among medical students in Tabuk City, Saudi Arabia; the causes were lecture timing, daytime sleepiness, and lecturers’ presentation skills. Most students were an intermediate chronotype that was not associated with classroom absence. Further larger multi-center studies are needed.
背景:讲座出勤率在医疗实践中是非常重要的。良好的睡眠卫生对学习成绩至关重要。因此,本研究旨在评估白天嗜睡与时间类型和逃课之间的关系。方法:对2022年4月至2022年7月Tabuk地区医学生进行横断面研究。随机抽取了334名医学生。采用基于日间嗜睡量表、早晚性问卷和逃课风险的标准化问卷。学生们在两周内详细描述了他们的睡眠习惯,然后回答了由研究人员直接分发的问卷,研究人员负责解决任何困难。结果:在334名学生中,上个月有74.7%的学生逃课。最常见的缺席原因是讲师直接阅读幻灯片(72.8%),其次是讲座迟到(67.8%),讲师的演讲技巧(65.6%)和缺乏兴趣(57.9%)。40.1%的学生白天嗜睡明显,并且与逃课有关(Wald, 3.86, p值,0.049,95% CI, 0.19-0.91)。大多数是中间时间型(66.4%),其次是晚上时间型(24.2%),与逃课无关。结论:沙特塔布克市医学生逃课现象普遍;原因是讲课时间、白天困倦和讲师的演讲技巧。大多数学生属于中等时型,与缺课无关。需要进一步更大规模的多中心研究。
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引用次数: 0
Serum Cytokine Levels As Critical Parameters in Early Diagnosis of Disease Progression in COVID-19: A Pilot Study 血清细胞因子水平作为COVID-19疾病进展早期诊断的关键参数:一项初步研究
Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13603
Walaa Mohammedsaeed, Z. Alahmadey, N. Manzoor
Background: The severity of Coronavirus disease 2019 (COVID-19) has been proposed to be associated with cytokine dysregulation. A significant number of patients become serious and need intensive care in hospitals. Methods: The concentrations of cytokines interleukin (IL-6, IL-10) and tumor necrosis factor (TNF) were estimated using enzyme-linked immunosorbent assay (ELISA) in serum samples of 60 adult patients infected with SARS-CoV-2 along with 50 healthy controls of the same age. The mean age of the subjects was 50-52 years and included an equal number of males and females. The patients were further grouped as severe (38 patients) and non-severe cases (22 patients). Results: The mean serum cytokine levels were significantly higher in the COVID-19 patients than in the healthy controls. IL-6 was excessively elevated in comparison to IL-10 and TNF. Comparative analysis of severe versus non-severe cases revealed only slight alterations in the cytokine levels: IL-6 being the most elevated in severe cases. The concentration of the liver enzyme ALT was higher than AST in both severe and non-severe cases. The mean concentration of serum electrolytes (Na, K, and Ca) did not vary much between the patients and healthy controls. Conclusion: There was a significant positive correlation between the levels of cytokines serum biomarkers in COVID-19 patients. It may be suggested that early detection of cytokines, especially IL-6 and serum biomarkers can help predict disease prognosis and severity in COVID-19 patients.
背景:已经提出冠状病毒病2019 (COVID-19)的严重程度与细胞因子失调有关。大量患者病情严重,需要在医院接受重症监护。方法:采用酶联免疫吸附试验(ELISA)测定60例成年SARS-CoV-2感染患者血清中白细胞介素(IL-6、IL-10)和肿瘤坏死因子(TNF)的浓度。研究对象的平均年龄为50-52岁,男女人数相等。患者进一步分为重症(38例)和非重症(22例)。结果:新冠肺炎患者血清细胞因子水平明显高于健康对照组。与IL-10和TNF相比,IL-6过高。重症病例与非重症病例的比较分析显示,细胞因子水平只有轻微变化:IL-6在重症病例中升高最多。重型和非重型患者肝酶ALT浓度均高于AST。血清电解质(钠、钾和钙)的平均浓度在患者和健康对照组之间没有太大差异。结论:新冠肺炎患者血清细胞因子生物标志物水平呈显著正相关。提示早期检测细胞因子,特别是IL-6和血清生物标志物有助于预测COVID-19患者的疾病预后和严重程度。
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引用次数: 0
Editorial – The Importance of Peer Review and Guidelines for Becoming a Reviewer 编辑-同行评议的重要性和成为评审员的指导方针
Pub Date : 2023-06-30 DOI: 10.18502/sjms.v18i2.13597
Emily Choynowski
This is an Editorial and does not have an abstract. Please download the PDF or view the article in HTML.
这是一篇社论,没有摘要。请下载PDF或以HTML格式阅览文章。
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引用次数: 0
Review of Plastic and Reconstructive Surgery in a General Hospital Setting: Experience from a Developing Country 综合医院整形和重建手术综述:来自发展中国家的经验
Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12868
M. Bakhiet, Elbadwai Hassan-Mohamed HabibAlla, Sami Mahmoud Assil, Mohamed Daffalla Awadalla Gismalla
Background: Plastic and reconstructive surgery in developing countries and underserved areas are significantly limited and face changes to start a proper service. This study presents a review of plastic surgery services and experiences in a district hospital located in an underserved area.Methods: This descriptive, retrospective, hospital-based study was conducted to review patients who presented to the plastic and reconstruction departments from January 2014 to January 2015. All patients seen in the outpatient clinic or emergency departments for plastic surgical consultation or management were included in the study.Results: The total of 403 cases fulfilled the inclusion criteria. The emergency surgical operation performed in our unit were distributed in the following descending order; fingertip injury (32%), cut wrist (12.7%), cut extensor tendon (9.9%), gunshot injuries (9.4%), fracture of a small bone of the hand (8.3%), and lower limb trauma. Surgery for congenital deformities constituted the most elective operation done in our unit (31.6 %), followed by tumor surgery (18.7%), burn surgery (17.3%), aesthetic surgery procedure (12.2%), and other miscellaneous cases (12.2%).Conclusion: This report demonstrates the efficacy of secondary hospital setting to accommodate a large volume of patients during the first year of establishment, and further predicting development needs, staff training, and governmental support.
背景:整形和重建手术在发展中国家和服务不足的地区明显有限,并面临变革,以开始适当的服务。本研究提出了整形手术的服务和经验的审查,在一个地区医院位于服务不足的地区。方法:对2014年1月至2015年1月在整形与重建科就诊的患者进行描述性、回顾性、以医院为基础的研究。所有在门诊或急诊科接受整形外科咨询或治疗的患者都被纳入研究。结果:403例符合纳入标准。我单位急诊外科手术数量由高到低依次分布:指尖损伤(32%)、腕部割伤(12.7%)、伸肌腱割伤(9.9%)、枪伤(9.4%)、手部小骨骨折(8.3%)和下肢创伤。先天性畸形手术是我们科室最多的选择性手术(31.6%),其次是肿瘤手术(18.7%)、烧伤手术(17.3%)、美容手术(12.2%)和其他杂项手术(12.2%)。结论:本报告证明了二级医院设置在建立的第一年容纳大量患者的有效性,并进一步预测了发展需求、工作人员培训和政府支持。
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引用次数: 0
A Tale of 5Ms: Massive Uterine Leiomyoma Mimicking Ovarian Malignancy along with Multiple Fibroids Displaying Multiple Degenerations 5Ms的故事:巨大的子宫平滑肌瘤,类似卵巢恶性肿瘤,并伴有多发性肌瘤,表现为多发性变性
Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12870
A. Koul, A. Shetty, Nidha Gaffoor, N. Murali, N. Prasad
Background: Leiomyomas are by far the commonest uterine neoplasms in the female reproductive age group. Giant leiomyomas are quite scarce and when longstanding tend to undergo various degenerations owing to decreased blood supply which on imaging may simulate malignancy owing to compromised blood supply and may simulate malignancy on imaging.Case Presentation: We present a case of a 48-year-old post-menopausal multiparous woman complaining of intermittent lower abdominal pain for a month. Suspected as an ovarian tumor clinically and on ultrasound, this was seconded by raised serum CA125 levels. Histopathological examination gave a definitive diagnosis of a giant uterine leiomyoma along with multiple fibroids exhibiting multiple degenerations.Conclusion: Degenerated leiomyomas can masquerade malignancy and hence should be one of the first differentials in women of reproductive age group presenting with complex abdominopelvic masses.
背景:平滑肌瘤是女性育龄期最常见的子宫肿瘤。巨大的平滑肌瘤是非常罕见的,当长期存在时,往往会发生各种变性,因为血液供应减少,在成像上可能模拟恶性肿瘤,因为血液供应受损,可能模拟恶性肿瘤。病例介绍:我们提出一个48岁的绝经后多胞胎妇女抱怨间歇性下腹痛一个月。临床和超声检查怀疑为卵巢肿瘤,血清CA125水平升高。组织病理学检查明确诊断为巨大子宫平滑肌瘤并多发性肌瘤,表现为多发性变性。结论:退行性平滑肌瘤可伪装成恶性肿瘤,应作为育龄期女性复杂骨盆肿块的首要鉴别指标之一。
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引用次数: 0
The Confusing Tale of Foreign Body Gastric Outlet Obstruction 令人困惑的异物胃出口梗阻
Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12869
Nader Mutwakel Osman
Background: Duplication cysts are rare congenital anomalies that can occur anywhere in the gastrointestinal tract from the mouth up to the anus. Acquired gastric outlet obstruction (GOO) during infancy beyond the neonatal period is a very rare condition and should be considered when other causes of GOO such as infantile hypertrophic pyloric stenosis, antral diaphragm, and pyloric atresia are excluded.Case Presentation: We report a one-year old female infant who presented with an acute onset of copious persistent vomiting that was initially diagnosed with a duplication cyst of the duodenum, but was found to have GOO after surgical exploration.Conclusion: Clinicians should be mindful of the common causes of GOO and have a high index of suspicion for acquired causes.
背景:重复囊肿是一种罕见的先天性异常,可以发生在从口腔到肛门的胃肠道的任何地方。婴儿期以后的获得性胃出口梗阻(GOO)是一种非常罕见的情况,当排除其他原因的GOO如婴儿肥厚性幽门狭窄,膈窦和幽门闭锁时应予以考虑。病例介绍:我们报告了一个一岁的女婴,她表现为急性发作的大量持续呕吐,最初被诊断为十二指肠重复囊肿,但在手术探查后发现有粘稠。结论:临床医生应注意粘粘症的常见病因,并对获得性病因高度怀疑。
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引用次数: 0
COVID-19 Vaccine and Role of Community Pharmacists COVID-19疫苗及社区药师的作用
Pub Date : 2023-03-31 DOI: 10.18502/sjms.v18i1.12873
Mayyda Asif Bajwa, K. Ashiq
This is a Letter and does not have an abstract. Please download the PDF or view the article in HTML.
这是一封信,没有摘要。请下载PDF或以HTML格式阅览文章。
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引用次数: 0
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Sudan journal of medical sciences
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