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Efficacy and Safety of Gum Arabic on Renal Failure Patients: Systematic Review and Meta-analysis 阿拉伯胶对肾衰竭患者的疗效和安全性:系统评价和荟萃分析
Pub Date : 2022-12-31 DOI: 10.18502/sjms.v17i4.12547
Selma Abdelrahman Hussein, Hammad Ali Fadlalmola, Suzy Munir Salama, Eyas Gaffar Osman, Abdalbasit Adam Mariod
Background: Chronic Renal Failure (CRF) is a long-term disease caused by progressive kidney dysfunction due to many reasons leading to a significant rise in serum levels of creatinine and urea reaching the advanced stage where the patient goes for frequent hemodialysis. This study aims to discuss the evaluation of the efficacy of gum Arabic (GA) supplementation on the serum level of creatinine, urea, sodium, and potassium in CRF patients. Methods: Four databases PubMed, Web of Science, Scopus, and the Cochrane Library were searched for clinical trials assessment of gum Arabic intervention in CRF patients. Animal trials and experimental protocols were excluded. Screening of data and data extraction were done by two reviewers independently of each other. Meta-analysis was conducted on the selected studies using RevMan and the resulting description was summarized through the Forest plot tool on the efficacy of GA on 4 variables, creatinine, urea, sodium, and potassium in CRF patients. Results: From 574 studies searched, only 4 studies were included in this systemic review and meta-analysis. Although one of the studies had proved the objectives of the review but it was removed from the meta-analysis due to the heterogeneity caused by its inclusion. Conclusion: The few studies included in the current review revealed significant efficacy of GA treatment on the serum level of creatinine, urea, and sodium, but not potassium.
背景:慢性肾衰竭(Chronic Renal Failure, CRF)是一种由进行性肾功能障碍引起的长期疾病,由于多种原因导致血清肌酐和尿素水平显著升高,达到晚期,患者需要频繁的血液透析。本研究旨在探讨阿拉伯树胶(GA)补充剂对慢性肾功能衰竭患者血清肌酐、尿素、钠和钾水平的影响。方法:检索PubMed、Web of Science、Scopus和Cochrane图书馆四个数据库,检索评估阿拉伯胶干预治疗CRF患者的临床试验。排除动物试验和实验方案。数据筛选和数据提取由两位独立的审稿人完成。使用RevMan对选定的研究进行meta分析,并通过Forest绘图工具总结GA对CRF患者肌酐、尿素、钠和钾4个变量的疗效。结果:在574项研究中,只有4项研究被纳入系统评价和荟萃分析。虽然其中一项研究证实了综述的目的,但由于纳入的异质性,该研究被从meta分析中删除。结论:本综述中包含的少数研究显示,GA治疗对血清肌酐、尿素和钠水平有显著疗效,但对钾水平无显著影响。
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引用次数: 0
Editorial – “Together We Build Our Health”: Paving Way Forward Through Analyzing the Context and Ensuring Wide Participation in the First and Second Health Forums in Sudan 社论- "我们共同建设健康":通过分析背景和确保广泛参与苏丹第一和第二届卫生论坛为前进铺平道路
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12077
Faihaa Dafalla, H. Awadalla, N. Husain
This is an Editorial and does not have an abstract. Please download the PDF or view the article HTML.
这是一篇社论,没有摘要。请下载PDF或查看文章HTML。
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引用次数: 0
Assessment of Variation in Clinical Presentation of Visceral Leishmaniasis Among Patients Attending the Tropical Diseases Teaching Hospital in Sudan 苏丹热带病教学医院内脏利什曼病临床表现差异评估
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12110
Hammam Abdalrhman Altom Mohammed Ahmed, Ahmed Ali Ahmed Musa, Ahmed Mahmoud, Sayed Sayedahmed, Shiraz Bashir Jabralseed Mohammed, Ehssan Farouk Mohamed Ahmed, Anas Mohamed, A. Nail
Background: Visceral leishmaniasis (also known as Kala-azar) is a systemic parasitic infection with many clinical presentations. The present study assesses the variation in presentations among patients who attended the Tropical Diseases Teaching Hospital (TDTH) in Khartoum, Sudan. Methods: This analytical cross-sectional, hospital-based study was conducted at the TDTH between November 2019 and September 2020. Medical records of patients who presented at the TDTH were reviewed using a structured data extraction checklist. The Chi-square test was used to determine the associations between sociodemographic and clinical presentations of patients. P-value < 0.05 was considered as statistically significant. Results: Out of 195 patients, 79.5% were male and 48.2% were <31 years old. Fever was the main clinical presentation (90.2%) while 53.3% presented with weight loss and 72.3% and 39% presented, respectively, with splenomegaly and hepatomegaly. HIV was detected in 4.6% of the patients. RK39 was the main diagnostic test. We found a significant association between the abdominal distention and the age of the patients (P < 0.05) – age groups 11–20 and 41–50 years were more likely to present with abdominal distention than other age groups. Conclusion: There is no exact clinical presentation or routine laboratory findings that are pathognomonic for visceral leishmaniasis; therefore, it should be considered in the differential diagnosis of any patient with fever, weight loss, and abdominal distention, and among patients with HIV.
背景:内脏利什曼病(又称黑热病)是一种具有多种临床表现的全身性寄生虫感染。本研究评估了在苏丹喀土穆的热带病教学医院(TDTH)就诊的患者的表现差异。方法:在2019年11月至2020年9月期间,在TDTH进行了这项基于医院的横断面分析研究。使用结构化数据提取检查表对在TDTH就诊的患者的医疗记录进行了审查。卡方检验用于确定社会人口学与患者临床表现之间的关系。p值< 0.05认为有统计学意义。结果:195例患者中男性占79.5%,年龄<31岁占48.2%。发热为主要临床表现(90.2%),体重减轻为53.3%,脾肿大和肝肿大分别为72.3%和39%。4.6%的患者被检测出艾滋病毒。RK39是主要的诊断试验。我们发现腹胀与患者的年龄有显著相关性(P < 0.05), 11-20岁和41-50岁年龄组比其他年龄组更容易出现腹胀。结论:没有确切的临床表现或常规实验室结果是内脏利什曼病的病理特征;因此,在任何有发热、体重减轻、腹胀的患者和艾滋病毒感染者的鉴别诊断中都应考虑到这一点。
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引用次数: 0
Variations of Arterial Supply of the Liver: C.T. Angiographic Study Among Sudanese Adults 苏丹成人肝脏动脉供应的变化:ct血管造影研究
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12121
Nidal Abubaker Harun, Mohamed A/Salam Nurein, T. O. Ali, Tarig Gasim Mohamed Alarabi, K. Ali, Heitham M. Mohammed, A. Abdalla, Abulqasim M. B. Siddeeg, A. G. E. Salih, S. Ahmed
Hepatobiliary surgery through laparoscopic approach is becoming a routine. Knowledge of extrahepatic arterial tree is essential for surgical and imaging procedures. Anatomical complexity is expected since the liver is developed by mergingof lobules with its separate blood supply. This makes a wide range of variations in the pattern of vascular arrangement and so reinforces the need for an accurate understanding of full spectrum of variations. This study aimed to investigate the variations in origin and distribution of extrahepatic arterial supply. Fifty volunteers (32 males and 18 females) aged 20–70 years were randomly recruited from the department of CT scan in Al Amal Hospital, Khartoum North, Sudan. The patients were already candidates for CT angiography with contrast for conditions other than hepatobiliary diseases. The reported data is related to those who accepted to participate in the study. Patients with history of hepatobiliary disease were excluded. 3D views of the scans were treated and the extrahepatic arterial tree was traced in a computer-based software. Key findings suggest that Michel’s classification was considered the standard template for description – 76% of them showed Michel’s type I classification. Types III and V constituted about 2%. About 4% of the cases were represented by types VI and IX. Other types of variations constituted about 12%. To conclude, although type I classification which describes the textbook pattern of hepatic artery distribution was significantly detected among the Sudanese population, other variants were to be considered since they are related to major arteries like aorta and superior mesenteric.
腹腔镜肝胆手术已成为常规手术。肝外动脉树的知识对于外科和影像学操作是必不可少的。解剖上的复杂性是可以预料的,因为肝脏是由小叶和其独立的血液供应合并而成的。这使得血管排列模式的变化范围很广,因此加强了对全谱变化的准确理解的需要。本研究旨在探讨肝外动脉供应的来源和分布的变化。从苏丹喀土穆北部Al Amal医院CT扫描科随机招募50名年龄在20-70岁之间的志愿者(男32名,女18名)。除肝胆疾病外,这些患者已经可以进行CT血管造影对比。报告的数据与那些接受参与研究的人有关。排除有肝胆疾病史的患者。对扫描的三维视图进行处理,并在基于计算机的软件中跟踪肝外动脉树。关键发现表明,米歇尔的分类被认为是描述的标准模板——76%的分类显示米歇尔的I型分类。III型和V型约占2%。约4%的病例为第VI和第IX型。其他类型的变化约占12%。综上所述,尽管在苏丹人群中显著发现了描述肝动脉分布的教科书模式的I型分类,但由于它们与主动脉和肠系膜上动脉等大动脉有关,因此需要考虑其他变体。
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引用次数: 0
Diagnostic Reference Levels in Mammography in the Asian Context 亚洲地区乳腺x线摄影诊断参考水平
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12128
Chamudi Ishara Rajamuni, B. Weerakoon
Background: Breast cancer is the most frequent cancer among the female population globally. Therefore, early detection is helpful for effective treatments and to reduce the mortality rate. Mammography is a radiological examination done with low-energy X-rays to detect abnormalities in breast tissue. This study aims to review the literature to evaluate the techniques, protocols, and conversion factors used to determine the diagnostic reference levels (DRLs); within the Asian continent using both phantom- and patient-based data. Methods: Related articles were systematically reviewed via Pub Med, Google scholar, and freehand search with the aid of relevant terms. Related abstracts in English were screened, and suitable articles were selected after reviewing the full-text. Four hundred and thirty abstracts were screened for relevance, and 12 articles were selected. Results: The study comprises four phantom-based and eight patient-based studies. The studies varied between the types of test subjects, conversion factors, breast compression thickness, and dose calculation protocols. This obstructs continuing the DRLs with the updates and comparisons among countries. Establishments of DRLs in Asian countries are less than the rest of the world. DRLs should be measured continuously, and should be updated based on other clinical parameters of the patients. Conclusion: DRLs in mammography were measured from time to time in different geographical locations in Asia by following various techniques. But when compared with the other regions of the world, there is less consideration for establishing DRLs in Asia. There should be standard protocols and updated conversion factors according to the advancements of the technology to ensure radiation protection with optimal absorbed dose with appropriate image quality.
背景:乳腺癌是全球女性人群中最常见的癌症。因此,早期发现有助于有效治疗,降低死亡率。乳房x线照相术是一种用低能x射线检测乳腺组织异常的放射学检查。本研究旨在回顾文献,以评估用于确定诊断参考水平(drl)的技术、方案和转换因子;在亚洲大陆范围内使用基于幻影和基于患者的数据。方法:通过Pub Med、Google scholar、徒手检索等方法,系统检索相关文献。筛选相关英文摘要,审读全文后选择合适的文章。对430篇摘要进行相关性筛选,筛选出12篇文章。结果:本研究包括4项基于幻影的研究和8项基于患者的研究。这些研究因试验对象的类型、转换因子、乳房压缩厚度和剂量计算方案而异。这阻碍了在更新和比较国家间的情况下继续进行drl。与世界其他地区相比,亚洲国家设立的drl较少。drl应持续测量,并应根据患者的其他临床参数进行更新。结论:在亚洲不同地区,通过采用不同的技术,可以不时地测量乳房x线摄影中的drl。但与世界其他地区相比,在亚洲建立drl的考虑较少。应根据技术的进步制定标准方案和更新转换系数,以确保具有最佳吸收剂量和适当图像质量的辐射防护。
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引用次数: 0
Shaping Healthcare System Under Industry 5.0: Trends and Barriers 在工业5.0下塑造医疗保健系统:趋势和障碍
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12115
Z. Asim
This is a Letter to the Editor and does not have an abstract. Please download the PDF or view the article HTML.
这是一封给编辑的信,没有摘要。请下载PDF或查看文章HTML。
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引用次数: 1
Adherence to Immunosuppressive Medications in Kidney Transplant Patients at Three Centers in Khartoum State, Sudan: A Cross-sectional Hospital Study 苏丹喀土穆州三个中心肾移植患者坚持使用免疫抑制药物:一项横断面医院研究
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12085
Alaa A. Abbas, Manhal Eltigani Ahmed, S. Mohammed, Shahd Shakir Gar-Alnabi, W. Mohammed, Musaab Ahmed, M. H. Ahmed, S. Badi
Background: Graft survival post-kidney transplantation is of paramount importance to patients and nephrologists. Nonadherence to immunosuppressive therapy can be associated with deterioration of renal function and graft rejection. This study aimed to evaluate the adherence to immunosuppressive medications in kidney transplant patients at three centers in Khartoum, Sudan. Methods: In this descriptive cross-sectional hospital-based survey, 277 post-kidneytransplant patients were recruited. Data were collected using a questionnaire and analyzed using the SPSS v.23. Our scoring method was calculated based on Morisky Medication Adherence Scale (MMAS-8) related to immunosuppressive medications and was expressed as questions in the questionnaire; every correct answer was given one mark, then the marks were gathered and their summation was expressed. Results: Overall, 33% ,45%, and 22% of the studied participants reported high, medium, and low adherence, respectively. The major factor for nonadherence was forgetfulness affecting 36.1% of those who did not adhere. The cost of the immunosuppressive medications did not negatively affect any of the participants’ adherence (100%). However, a significant association was seen between adherence and occupational status, duration of transplantation, shortage of immunosuppressants, recognizing the name of immunosuppressant, side effect, and forgetfulness (P-values = 0.002, 0.01, 0.006 , 0.000, 0.022, and 0.000, respectively). Logistic regression analysis showed a significant association with occupational status, side effects, and forgetfulness Conclusion: Only one-third of the participants were classed as “highly adherent” to their immunosuppressant medications. Factors that can affect adherence to immunosuppressant medications were occupational status, side effects, and forgetfulness.
背景:肾移植后移植物的存活对患者和肾病学家至关重要。不坚持免疫抑制治疗可能与肾功能恶化和移植物排斥反应有关。本研究旨在评估苏丹喀土穆三个中心肾移植患者对免疫抑制药物的依从性。方法:在这项以医院为基础的描述性横断面调查中,招募了277名肾移植后患者。使用问卷调查收集数据,并使用SPSS v.23进行分析。我们的评分方法基于与免疫抑制药物相关的Morisky药物依从性量表(MMAS-8)进行计算,并以问卷中的问题表示;每个正确的答案都给一个分数,然后把分数加起来,并把分数的总和表示出来。结果:总体而言,33%、45%和22%的研究参与者分别报告了高、中、低依从性。不坚持服药的主要原因是健忘,36.1%的人没有坚持服药。免疫抑制药物的费用对任何参与者的依从性没有负面影响(100%)。然而,依从性与职业状况、移植持续时间、免疫抑制剂短缺、认识免疫抑制剂名称、副作用和遗忘之间存在显著关联(p值分别为0.002、0.01、0.006、0.000、0.022和0.000)。逻辑回归分析显示与职业状况、副作用和健忘有显著关联。结论:只有三分之一的参与者被归类为“高度坚持”免疫抑制药物。影响免疫抑制药物依从性的因素有职业状况、副作用和健忘。
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引用次数: 0
Knowledge, Attitude, and Practice toward Prevention of COVID-19 Among Nursing and Midwifery Students: A cross-sectional Study in Gorgan, Northern Iran 护理和助产专业学生预防COVID-19的知识、态度和实践:伊朗北部戈尔根的一项横断面研究
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12118
I. Firoozjaie, H. Khoddam, M. Mohamadi, Mahin Tatari, Seyedmahrokh A. Maddah
Background: Healthcare providers are high-risk groups for the novel coronavirus disease (COVID-19) infection. Nursing students are an essential part of high-risk healthcare providers. The aim of this study was to evaluate the knowledge, attitude, and practice of nursing and midwifery students at Golestan University of Medical Sciences (GOUMS) toward the prevention of COVID-19. Methods: This cross-sectional study was conducted on 174 nursing and midwifery students of GOUMS (northeast of IRAN) in 2020. Data were gathered using an online questionnaire comprising three parts – Knowledge (8 questions), Attitude (10 questions), and Practice (8 questions) toward the prevention of COVID-19. The range of scores in each subscale (knowledge, attitude, and preventive practices) were 8–24, 10–50, and 8–24, respectively. Data were analyzed using the SPSS v.16 software. The Mann–Whitney and Kruskal–Wallis tests were used for the analysis. Results: Overall, in this study, nursing and midwifery students had a good knowledge (mean score: 23.19 ± 2.56), a positive attitude (mean score: 45.48 ± 4.21), and appropriate practice (mean score: 23.30 ± 3.51) regarding COVID-19 prevention. Also, the results revealed a positive correlation between knowledge and attitude (r = 0.1, P = 0.18) and attitude and practice (r = 0.2, P = 0.01) among the students. Conclusion: The findings demonstrated a good preventive knowledge, attitude, and practice toward COVID-19 among nursing and midwifery students.
背景:医疗服务提供者是新型冠状病毒病(COVID-19)感染的高危人群。护理专业的学生是高风险医疗保健提供者的重要组成部分。本研究的目的是评估戈列斯坦医科大学(GOUMS)护理和助产专业学生对COVID-19预防的知识、态度和实践。方法:对2020年伊朗东北部GOUMS护理与助产学专业174名学生进行横断面研究。通过在线问卷收集数据,该问卷由三部分组成:对COVID-19预防的知识(8个问题)、态度(10个问题)和实践(8个问题)。各分量表(知识、态度和预防措施)得分范围分别为8-24、10-50和8-24。数据分析采用SPSS v.16软件。使用Mann-Whitney和Kruskal-Wallis检验进行分析。结果:总体而言,本研究护理助产学学生对新冠肺炎的预防知识(平均得分:23.19±2.56)、态度积极(平均得分:45.48±4.21)、行为得当(平均得分:23.30±3.51)。学生的知识与态度(r = 0.1, P = 0.18)、态度与实践(r = 0.2, P = 0.01)呈显著正相关。结论:护理学和助产学学生对COVID-19有良好的预防知识、态度和实践。
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引用次数: 0
Evaluation of Fine-needle Aspiration Cytology (FNAC) Sensitivity Compared to PCR for Diagnosing Tuberculosis Lymphadenitis 细针穿刺细胞学(FNAC)与PCR诊断结核性淋巴结炎的敏感性比较
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12103
O. Mustafa, Ebtehal Mohamed, A. Omer, Abdelmonem Mohamed, Sheima Abdemagid, Alaa I. Ali, N. Hassan, M. Khalil, Nagia Suliman
Background: Tuberculosis (TB) is a major healthcare burden in Sudan and other developing countries, it is considered the second most common cause of death from infectious diseases after those due to AIDS. In Sudan, TB lymphadenitis (TBLA) remains one of the major health problems. This descriptive cross-sectional study was conducted at the University of Medical Sciences and Technology (UMST) and Total Labcare Diagnostic Center (TDC). The study aims to compare the sensitivity of Fine Needle Aspiration Cytology (FNAC) smears with that of the Polymerase Chain Reaction (PCR) for the diagnosis of TBLA. Materials and Methods: Fifty-five dry smears were obtained using fine-needle aspiration (FNA) from an enlarged lymph node. PCR was applied to detect the target gene (IS6110). May-Grunwald-Giemsa (MGG) or Diff quick stains were used. Results: Two (4%) patients with TBLA were non-necrotic, while fifty-three of them (96%) were necrotic. Moreover, 17 (30%) fine-needle lymph node aspiration specimens were confirmed by PCR to be positive for Mycobacterium tuberculosis complex (MTB complex) while 38 (70%) of them were negative. Conclusion: There was no significant difference between the sensitivity of PCR and that of FNAC (P-value = 0.33).
背景:结核病(TB)是苏丹和其他发展中国家的主要医疗负担,它被认为是仅次于艾滋病的第二大传染病死亡原因。在苏丹,结核性淋巴结炎(TBLA)仍然是主要的卫生问题之一。这项描述性横断面研究是在医学科技大学(UMST)和Total Labcare诊断中心(TDC)进行的。本研究旨在比较细针吸细胞学(FNAC)涂片与聚合酶链反应(PCR)诊断TBLA的敏感性。材料和方法:采用细针抽吸法(FNA)从肿大的淋巴结上获得55张干涂片。采用PCR方法检测目的基因IS6110。使用May-Grunwald-Giemsa (MGG)或Diff快速染色。结果:2例(4%)TBLA患者无坏死,53例(96%)TBLA患者坏死。PCR检测细针淋巴结抽吸标本中结核分枝杆菌复合体阳性17例(30%),阴性38例(70%)。结论:PCR与FNAC的敏感性无显著差异(p值= 0.33)。
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引用次数: 0
Effectiveness of Health Awareness Module on Pregnant Women’s Perception on and Experience of Constipation at Saad Abu Alela – University Hospital, 2017 健康意识模块对萨阿德阿布阿莱拉孕妇便秘感知和体验的影响-大学医院,2017
Pub Date : 2022-09-30 DOI: 10.18502/sjms.v17i3.12079
F. Taha
Background: Pregnancy predisposes women to developing constipation, and hormonal and mechanical factors, sedentary lifestyle, and alteration of diet augments the condition, leading to discomforts experienced by pregnant women. However, this can be controlled through proper education and lifestyle modification. The present study aims to check the effect of health awareness education module on the reduction of constipation among pregnant women. Methods: A quasi-experimental study design was used. One hundred and twentyfive pregnant women were randomly selected from Saad Abu Alela Hospital between January and March 2017), and based on the ROME II criteria, 59 of them were found to have constipation. After obtaining consent from the women, health awareness module (information about constipation, dietary measures, increased fluid intake, and exercise) was offered to them. Data were collected by structured close-ended questionnaire for the knowledge, pre- and post-intervention, and checklists for the practice and follow-up of the weekly outcome over two months. Data were analyzed, and suitable statistical methods was used. P < 0.05 was considered as statistically significant. Results: The overall prevalence of constipation was 47.2% with a prevalence of 4%, 6.4%, and 36.8% in the first, second, and third trimesters of pregnancy, respectively. Pregnant women’s knowledge about constipation increased significantly from 16.9% pre- to 92.9 post-intervention with P = 0.000. The fiber diet intake, fluid intake, and exercise by pregnant women increased from 37.3%, 39%, and 13.6% pre- to 72.9%, 88.1%, and 49.1% post-intervention, respectively) with P = 0.001. Moreover, 46 (78%) women were relieved of constipation post-intervention. Conclusion: The health awareness module was very effective and significantly increased the level of knowledge, practice, and outcomes with respect to constipation in pregnant women.
背景:孕妇易患便秘,激素和机械因素、久坐不动的生活方式以及饮食的改变都加剧了便秘的发生,导致孕妇出现不适。然而,这可以通过适当的教育和改变生活方式来控制。本研究旨在检验健康意识教育模块对减少孕妇便秘的效果。方法:采用准实验研究设计。2017年1月至3月期间,从萨阿德阿布阿莱拉医院随机选择125名孕妇,根据ROME II标准,其中59名发现便秘。在获得妇女的同意后,向她们提供健康意识模块(关于便秘、饮食措施、增加液体摄入量和锻炼的信息)。数据收集采用结构化封闭式问卷调查的知识,干预前和干预后,检查表的做法和随访每周结果超过两个月。对资料进行分析,采用合适的统计方法。P < 0.05为差异有统计学意义。结果:便秘的总患病率为47.2%,其中妊娠前、中、晚期的患病率分别为4%、6.4%和36.8%。孕妇对便秘的知别率由干预前的16.9%提高到干预后的92.9%,P = 0.000。孕妇的纤维饮食摄入量、液体摄入量和锻炼分别从干预前的37.3%、39%和13.6%增加到干预后的72.9%、88.1%和49.1%,P = 0.001。此外,46名(78%)妇女在干预后便秘得到缓解。结论:健康意识模块非常有效,显著提高了孕妇对便秘的认识水平、实践水平和治疗效果。
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引用次数: 0
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Sudan journal of medical sciences
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