Indian Journal of Dental Research最新文献

Background: Candidalysin has been isolated initially from a pathogenic human fungus. The extent of cell elongation 1 (ECE1) gene codes for candidalysin of Candida albicans (C. albicans). This toxin is most important for epithelial immune activation, invasiveness and infection of the oral mucosa.

Aim: This study is aimed at detecting the ECE1 gene in C. albicans isolates from oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs).

Methods and material: A total of 60 C. albicans isolates from OSCC (n = 23), OPMDs (n = 23) and healthy subjects (n = 14) were subjected to a polymerase chain reaction (PCR) for the detection of ECE1 gene. A high prevalence of the ECE1 gene was observed among the C. albicans isolates from OSCC and OPMD compared to the isolates from healthy subjects. Statistical significance was observed for both OSCC and OPMD groups compared to the healthy group.

Results and conclusion: The results suggest the significant role of candidalysin in oral oncogenesis. The high odds and risk ratio specify a strong association between candidalysin and these conditions. Screening this gene in a large number of isolates would further reinforce their role in oncogenesis. Future studies in characterizing their virulence on normal cell lines would clarify the importance of candidalysin in promoting oncogenesis.

Objective: To evaluate the feasibility of the International Caries Classification and Management System (ICCMS) protocol in a hospital-based setting in India.

Methods: A total of 160 children, 3-6 years old children reporting with dental caries to a hospital-based setting were recruited. Risk-based management of dental caries was conducted and followed for one year as per the modified ICCMS protocol. The feasibility of the ICCMS protocol was evaluated based on treatment outcomes including symptom reduction, patient compliance, and time taken in risk assessment. Qualitative outcomes were assessed using a paired t-test, whereas the Wilcoxon signed-rank test assessed the change in quantitative variables from baseline to one year.

Results: A one-year follow-up assessment was completed for 139 children. Majority of children (101 = 72.7%) had high caries risk, while (38 = 27.3%) had moderate risk. A significant improvement was observed in terms of reduction in patient symptoms such as reducing the number of active caries, maintaining sound teeth, and maintaining restored teeth (P < 0.05). The time taken for risk assessment was also significantly reduced (mean difference 1.99 ± 3.37 min) at one-year recall.

Conclusion: The ICCMS protocol for caries management is feasible in terms of systematic symptom reduction in both moderate and high dental caries risk patients.

Abstract: Osteopetrosis, also known as marble bone disease, is a genetic condition characterised by generalised sclerosis of bones. The osteoclastic cells responsible for bone resorption are defective and nonfunctional. These patients tend to have low bone quality in spite of increased bone deposition and thus experience multiple fractures during their life span. The bones are dense with loss of corticomedullary differentiation. A case report of benign adult type of osteopetrosis wherein a 47-year-old man underwent simple dental extraction of maxillary posterior teeth that segued to chronic nonhealing osteomyelitis of the maxilla is presented. Sequestromy of the dead bone further complicated the secondary infection due to nonhealing of the surgical area. The patient was treated with a full course of antibiotics and is under regular follow-up. Since dental extractions can lead to osteomyelitis of jaw bones judicious evaluation and careful treatment planning are advised.

Abstract: The most prevalent mucogingival issues include insufficient gingival width, decreased vestibular depth, abnormal frenal attachment, gingival recession, pockets that reach the mucogingival junction, excess gingival, inconsistent gingival margin, excessive gingival display and abnormal gingival colour. Numerous periodontal plastic operations have been used to treat these issues. However, each approach has its own drawbacks and is technique-dependent. Adequate depth of vestibule is necessary to maintain good oral health as shallow vestibule leads to accumulation of food and thus impedes oral hygiene maintenance. This case series describes a vestibular deepening procedure performed using modification of periosteal fenestration technique. This technique includes a series of eight cases of shallow vestibule where vestibular deepening was conducted by giving a full-thickness incision to expose the periosteum and create a window of fenestration followed by suturing the labial mucosa to the periosteum at the apical level. The results reported an excellent post-operative outcome showing increased depth of the vestibule.

Abstract: Trichofolliculoma is a rare benign, hamartomatous adnexal tumour of the skin. Aetiology seems to be unclear. It is usually seen in adults, with no gender predilection. The most commonly involved sites are the face and scalp. It appears as a papule or nodule with small protruding hairs, which is a classic feature of the tumour. It has unique diagnostic and histopathological features that help in making a definitive diagnosis. Here, we report an exemplary case of an adult male patient aged 45 years with a gradual progressive diffuse swelling on the left side of the face for 1.5 years. Clinically, it was diagnosed as a sebaceous cyst, but after the biopsy histopathological evaluation was performed, and the diagnosis was confirmed as trichofolliculoma.

Background: Premature degradation is the problem of maxillofacial silicones, significantly affected by ultraviolet exposure, contributing to silicones photodegradation. Degradation necessitates frequent replacement of prostheses that increase the total cost of rehabilitation.

Aims: This study evaluated the effect of bisoctrizole on the ultraviolet absorption properties of silicone material and the stability of this absorption over time. Also, the bisoctrizole effect on the surface roughness of silicone was evaluated.

Methods: There were 60 prepared specimens of room temperature-vulcanising maxillofacial silicone equally divided into two groups according to the conducted tests: ultraviolet absorption test and the surface roughness test. Each group was further subdivided into groups of 10 specimens based on the weight concentration of the ultraviolet (UV) absorber added: 0%, 1% and 2%. The UV absorbance of coloured specimens was measured before and after artificial weathering for 100 and 200 hours. Repeated-measures analysis of variance (ANOVA) was applied for UV absorption results, and one-way ANOVA was applied for the roughness test results to test the changing significances.

Result: Bisoctrizole incorporation led to a highly significant improvement in ultraviolet absorption in all groups, maintaining a high level even after subjecting the specimens to artificial weathering. Furthermore, the addition resulted in a significant increase in surface roughness as the concentration of bisoctrizole increased.

Conclusion: Despite the surface roughness changes, bisoctrizole demonstrated efficacy as a UV absorber for maxillofacial silicone, making it valuable for applications such as maxillofacial prosthetics that require UV protection.

Aims: This study aimed to investigate the rate and quality of maturation of the mineral component of impacted teeth 38 and 48 and a fragment of the human lower jaw with connective tissue dysplasia (CTD) in different periods of postnatal ontogenesis.

Methods and material: The study involved 102 males (76 with CTD and 26 without CTD), divided into age groups: 31-40, 41-50 and 51-60 years. For medical reasons, teeth 38 and 48 were removed from each patient, as well as a fragment of the alveolar part of the lower jaw in the projection of teeth 38 and 48 measuring 0.5 × 0.5 cm. The odontological parameters, the mineral density of the enamel and the lower jaw, the length and width of the enamel prisms, the spatial organisation of collagen fibrils and the dimensions of the bone plates of the lower jaw were determined.

Results: A decrease in optical density was observed at the age of 41-50 and 51-60 years with dysplasia, which indicated a decrease in mineral density and the presence of total areas of hypomineralisation relative to the age of 31-40 years. In the age groups of 41-50 and 51-60 years, pronounced sclerosis and deformation of the delimiting elements were observed at the border of the connective tissue structures and the periosteum. At the age of 31-40 years, the level of stratification of the bone plates was local; after 40 years, it was generalised.

Conclusions: Progressive osteoporosis of the lower jaw and incomplete amelogenesis are obstacles to the correct and harmonious eruption of the lower 'wisdom' teeth after 30 years.