Introduction: Ankylosing spondylitis (AS) is an autoimmune disease, which causes mild to severe clinical symptoms in patients. Several inherited and acquired factors are involved in the pathogenesis of the disease. Human leukocyte antigen B27 (HLA-B27) is one of the factors, whose expression affects patients’ susceptibility to AS. Objectives: In this study, we evaluated HLA-B27 frequency in AS patients of Khuzestan province of Iran. Patients and Methods: The study population (N=114) including patients with AS. Patients were examined and confirmed by a rheumatologist based on New York modified criteria. Clinical information was extracted from patients’ documents. Furthermore, general characteristics of the patients and several clinical variables (physio-pathological, self-report, and imaging) were taken into consideration. Results: The results showed that 62.3% of the patients were HLA-B27 positive, while 37.7% of which were HLA-B27 negative. This difference was statistically significant (P <0.05). The disease duration was shown to be almost equal in both groups (i.e., HLA-B27 positive and HLA-B27 negative). According to the results, various clinical symptoms (like ocular complications and peripheral arthritis) were observed in patients, and the complications of which were higher in HLA-B27 negative patients compared to HLA-B27 positive ones (P <0.05). Besides, it was seen that the male patients have shown a higher physio-pathological (using polymerase chain reaction [PCR] technique) report for positive HLA-B27 and a higher magnetic resonance imaging involvement compared with females, whereas the women showed higher disease activity score i.e., higher mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) value. Conclusion: For the AS patients, negative HLA-B27 cases show more progressive involvement sacroiliac joints compared with the positive HLA-B27 cases. More importantly, of hundred percent of patients who responded to anti-tumor necrosis factor (TNF) treatment, 52.6% were positive for the HLA-B27 antigen, and 47.4% were negative for the HLA-B27 antigen. Overall, it can be said that HLA-B27 lonely is not involved in the pathogenesis of AS and environmental factors should be investigated and involved in the disease development.
{"title":"Evaluation of HLA-B27 frequency in patients with ankylosing spondylitis, and its relationship with clinical symptoms in Khuzestan province","authors":"Mahnoosh Davodi, F. Nokhostin, Elham Rajaei","doi":"10.34172/ipp.2023.39472","DOIUrl":"https://doi.org/10.34172/ipp.2023.39472","url":null,"abstract":"Introduction: Ankylosing spondylitis (AS) is an autoimmune disease, which causes mild to severe clinical symptoms in patients. Several inherited and acquired factors are involved in the pathogenesis of the disease. Human leukocyte antigen B27 (HLA-B27) is one of the factors, whose expression affects patients’ susceptibility to AS. Objectives: In this study, we evaluated HLA-B27 frequency in AS patients of Khuzestan province of Iran. Patients and Methods: The study population (N=114) including patients with AS. Patients were examined and confirmed by a rheumatologist based on New York modified criteria. Clinical information was extracted from patients’ documents. Furthermore, general characteristics of the patients and several clinical variables (physio-pathological, self-report, and imaging) were taken into consideration. Results: The results showed that 62.3% of the patients were HLA-B27 positive, while 37.7% of which were HLA-B27 negative. This difference was statistically significant (P <0.05). The disease duration was shown to be almost equal in both groups (i.e., HLA-B27 positive and HLA-B27 negative). According to the results, various clinical symptoms (like ocular complications and peripheral arthritis) were observed in patients, and the complications of which were higher in HLA-B27 negative patients compared to HLA-B27 positive ones (P <0.05). Besides, it was seen that the male patients have shown a higher physio-pathological (using polymerase chain reaction [PCR] technique) report for positive HLA-B27 and a higher magnetic resonance imaging involvement compared with females, whereas the women showed higher disease activity score i.e., higher mean Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) value. Conclusion: For the AS patients, negative HLA-B27 cases show more progressive involvement sacroiliac joints compared with the positive HLA-B27 cases. More importantly, of hundred percent of patients who responded to anti-tumor necrosis factor (TNF) treatment, 52.6% were positive for the HLA-B27 antigen, and 47.4% were negative for the HLA-B27 antigen. Overall, it can be said that HLA-B27 lonely is not involved in the pathogenesis of AS and environmental factors should be investigated and involved in the disease development.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45370215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Khanjani, F. Farahbod, E. Zarean, M. Tarrahi, B. Mohammadi
Introduction: Fetal growth restriction (FGR) is a major obstetric complication associated with an increased risk of adverse perinatal outcomes. Objectives: This study aimed to evaluate the relationship between Doppler parameters, including the cerebroplacental ratio (CPR), umbilicocerebral ratio (UCR), and cerebro-placental-uterine ratio (CPUR), with adverse perinatal outcomes in singleton pregnancies complicated by FGR. Patients and Methods: This was a prospective study of 100 women with a singleton pregnancy 28 and 36.8 weeks of gestation was complicated by FGR and mild abnormalities. Feto-maternal Doppler examinations were conducted by the CPR, UCR, and CPUR parameters. Adverse outcomes were defined as Apgar score <7 at 5 minutes, preterm birth <37-week, neonatal intensive care unit (NICU) admission, fetal distress, and emergency cesarean section. These outcome parameters were checked with the results of the last ultrasound which performed 1-2 weeks before delivery. Results: Mean umbilical artery pulsatility index (UA-PI) (1.18±0.31 versus 1.04±0.21, P=0.010) and mean uterine arteries (UtAs)-PI (1.18±0.45 versus 0.96±0.36, P=0.20) were significantly higher in pregnancies that experienced adverse perinatal outcomes than those that did not experience them. Mean CPUR (1.82±1.03 versus 2.25±0.83, P=0.039) was significantly lower in pregnancies that experienced adverse perinatal outcomes versus those that did not. In binary multivariate logistic regression analysis, CPR, UCR, and CPUR parameters were evaluated with adverse perinatal outcomes. Only CPUR had a significant relationship with adverse perinatal outcomes. CPUR had a substantial relationship with Apgar score <7 at 5 minutes (OR: 0.13; 95% CI: 0.02-0.63; P=0.012). Conclusion: CPUR is a new Doppler ratio associated with adverse perinatal outcomes in FGR pregnancies with minimal abnormalities.
胎儿生长受限(FGR)是与不良围产期结局风险增加相关的主要产科并发症。目的:本研究旨在评价单胎妊娠合并FGR患者的多普勒参数，包括脑胎盘比(CPR)、脐脑比(UCR)和脑胎盘子宫比(CPUR)与不良围产期结局的关系。患者和方法:这是一项前瞻性研究，100例单胎妊娠28周和36.8周合并FGR和轻度异常的妇女。通过心肺复苏术(CPR)、超声复苏术(UCR)和心肺复苏术(CPR)参数进行胎母多普勒检查。不良结局定义为5分钟时Apgar评分<7、早产<37周、新生儿重症监护病房(NICU)入院、胎儿窘迫和紧急剖宫产。这些结果参数与分娩前1-2周进行的最后一次超声结果进行核对。结果:围产期不良结局孕妇的平均脐动脉脉搏指数(UA-PI)(1.18±0.31比1.04±0.21,P=0.010)和平均子宫动脉指数(UtAs)-PI(1.18±0.45比0.96±0.36,P=0.20)显著高于未发生围产期不良结局孕妇。平均CPUR(1.82±1.03 vs 2.25±0.83,P=0.039)在经历不良围产期结局的妊娠中显著低于未经历不良围产期结局的妊娠。在二元多变量logistic回归分析中，CPR、UCR和CPUR参数与不良围产期结局进行评估。只有CPUR与围产期不良结局有显著关系。CPUR与5分钟Apgar评分<7有显著关系(OR: 0.13;95% ci: 0.02-0.63;P = 0.012)。结论:CPUR是一种新的多普勒比值，与FGR妊娠的不良围产期结局有关。
{"title":"Evaluation of the relation between cerebroplacental ratio, umbilical-cerebral ratio, and cerebro-placental-uterine ratio with the occurrence of adverse perinatal outcomes in pregnancies complicated by fetal growth restriction","authors":"S. Khanjani, F. Farahbod, E. Zarean, M. Tarrahi, B. Mohammadi","doi":"10.34172/ipp.2023.39503","DOIUrl":"https://doi.org/10.34172/ipp.2023.39503","url":null,"abstract":"Introduction: Fetal growth restriction (FGR) is a major obstetric complication associated with an increased risk of adverse perinatal outcomes. Objectives: This study aimed to evaluate the relationship between Doppler parameters, including the cerebroplacental ratio (CPR), umbilicocerebral ratio (UCR), and cerebro-placental-uterine ratio (CPUR), with adverse perinatal outcomes in singleton pregnancies complicated by FGR. Patients and Methods: This was a prospective study of 100 women with a singleton pregnancy 28 and 36.8 weeks of gestation was complicated by FGR and mild abnormalities. Feto-maternal Doppler examinations were conducted by the CPR, UCR, and CPUR parameters. Adverse outcomes were defined as Apgar score <7 at 5 minutes, preterm birth <37-week, neonatal intensive care unit (NICU) admission, fetal distress, and emergency cesarean section. These outcome parameters were checked with the results of the last ultrasound which performed 1-2 weeks before delivery. Results: Mean umbilical artery pulsatility index (UA-PI) (1.18±0.31 versus 1.04±0.21, P=0.010) and mean uterine arteries (UtAs)-PI (1.18±0.45 versus 0.96±0.36, P=0.20) were significantly higher in pregnancies that experienced adverse perinatal outcomes than those that did not experience them. Mean CPUR (1.82±1.03 versus 2.25±0.83, P=0.039) was significantly lower in pregnancies that experienced adverse perinatal outcomes versus those that did not. In binary multivariate logistic regression analysis, CPR, UCR, and CPUR parameters were evaluated with adverse perinatal outcomes. Only CPUR had a significant relationship with adverse perinatal outcomes. CPUR had a substantial relationship with Apgar score <7 at 5 minutes (OR: 0.13; 95% CI: 0.02-0.63; P=0.012). Conclusion: CPUR is a new Doppler ratio associated with adverse perinatal outcomes in FGR pregnancies with minimal abnormalities.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47175871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Insufficient information exists regarding the coronavirus disease 2019 (COVID-19) vaccination safety in pregnant women. Objectives: The present study compared the pregnancy and fetal outcomes among COVID-19-vaccinated and unvaccinated pregnant women. Patients and Methods: This cross-sectional study was conducted at Tabriz University of Medical Sciences (Tabriz, Iran) on 117 pregnant women (55 vaccinated women as the case group and 62 unvaccinated women as the control group) using census sampling in 2022. The maternal outcomes (death, admission to intensive care unit [ICU], premature birth, gestational hypertension, preeclampsia, oligohydramnios, and polyhydramnios) and neonatal outcomes (neonatal death, congenital disabilities, neonatal weight loss, admission to ICU, neonatal infection, neonatal fever, need for mechanical ventilation of the newborn, and one- and five-minute Apgar scores) were recorded. Then the two groups were compared using independent t-test, along with ANOVA and chi-square tests. Results: The number of women without pregnancy outcomes was marginally lower in the case group than in the control group (P=0.099). Gestational hypertension (P=0.312) and preterm birth were lower among unvaccinated women than among vaccinated women but this difference was not significant (P=0.089). Hospitalization in the neonatal intensive care unit (P=0.361), neonatal fever (P=0.259), and neonatal infection (P=0.079) were more common in infants born to vaccinated mothers than in infants born to unvaccinated women, although the difference not significant. Conclusion: Vaccination against COVID-19 appears to not be associated with an increased probability of maternal and neonatal complications.
{"title":"Comparison of pregnancy outcomes and neonatal complications between COVID–19-vaccinated and unvaccinated pregnant women in Tabriz, Iran","authors":"S. Taghavi, M. Dehdilani, M. Dehdilani","doi":"10.34172/ipp.2023.39520","DOIUrl":"https://doi.org/10.34172/ipp.2023.39520","url":null,"abstract":"Introduction: Insufficient information exists regarding the coronavirus disease 2019 (COVID-19) vaccination safety in pregnant women. Objectives: The present study compared the pregnancy and fetal outcomes among COVID-19-vaccinated and unvaccinated pregnant women. Patients and Methods: This cross-sectional study was conducted at Tabriz University of Medical Sciences (Tabriz, Iran) on 117 pregnant women (55 vaccinated women as the case group and 62 unvaccinated women as the control group) using census sampling in 2022. The maternal outcomes (death, admission to intensive care unit [ICU], premature birth, gestational hypertension, preeclampsia, oligohydramnios, and polyhydramnios) and neonatal outcomes (neonatal death, congenital disabilities, neonatal weight loss, admission to ICU, neonatal infection, neonatal fever, need for mechanical ventilation of the newborn, and one- and five-minute Apgar scores) were recorded. Then the two groups were compared using independent t-test, along with ANOVA and chi-square tests. Results: The number of women without pregnancy outcomes was marginally lower in the case group than in the control group (P=0.099). Gestational hypertension (P=0.312) and preterm birth were lower among unvaccinated women than among vaccinated women but this difference was not significant (P=0.089). Hospitalization in the neonatal intensive care unit (P=0.361), neonatal fever (P=0.259), and neonatal infection (P=0.079) were more common in infants born to vaccinated mothers than in infants born to unvaccinated women, although the difference not significant. Conclusion: Vaccination against COVID-19 appears to not be associated with an increased probability of maternal and neonatal complications.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49316253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Eslami, Giti Setoodeh, Sara Dehghan, Y. Khanchemehr, Reyhaneh Sadeghian, Mahsa Asadollahi Hamedani, Mohamad Khaledi, Mobin Mohammadtabar, Najmeh Parsai
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant appeared in South Africa for the first time. The high prevalence of its mortality in elderly patients has caused an increase in anxiety triggered by this disease in aged people. Objectives: The aim of this study is to evaluate the anxiety related-COVID-19 in the SARS-CoV-2 Omicron variant and its related factors in elderly patients who are candidates for cataract surgery. Patients and Methods: This descriptive-analytical study was conducted on 159 over 65 years old patients who are candidates for cataract surgery. Easy and accessible sampling methods were employed to select samples. Demographic characteristics sheet and the Corona Disease Anxiety Scale (CDAS) questionnaire were filled out by them. Fisher’s exact test, Mann-Whitney U and binary logistic regression tests were conducted for data analysis. Results: The results showed that out of 159 patients, 57.9% were female, with a mean age of 73.09 ± 9.64 years. The anxiety level of 70.4% of patients was mild or non-anxiety and 29.6% was moderate or severe. The correlation between anxiety related to COVID-19 with age, gender, vaccination status and history of being infected by COVID-19 was significant (P<0.05); however, the correlation with the job, place of residence and marital status were not significant (P>0.05). Conclusion: We concluded that older age, female gender, non-vaccinated and having no history of being infected by COVID-19 are the most influential factors that increase anxiety triggered by COVID-19 in elderly patients.
{"title":"SARS-CoV-2 Omicron variant; psychological effect and influencing factors in elderly patients","authors":"J. Eslami, Giti Setoodeh, Sara Dehghan, Y. Khanchemehr, Reyhaneh Sadeghian, Mahsa Asadollahi Hamedani, Mohamad Khaledi, Mobin Mohammadtabar, Najmeh Parsai","doi":"10.34172/ipp.2023.39491","DOIUrl":"https://doi.org/10.34172/ipp.2023.39491","url":null,"abstract":"Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant appeared in South Africa for the first time. The high prevalence of its mortality in elderly patients has caused an increase in anxiety triggered by this disease in aged people. Objectives: The aim of this study is to evaluate the anxiety related-COVID-19 in the SARS-CoV-2 Omicron variant and its related factors in elderly patients who are candidates for cataract surgery. Patients and Methods: This descriptive-analytical study was conducted on 159 over 65 years old patients who are candidates for cataract surgery. Easy and accessible sampling methods were employed to select samples. Demographic characteristics sheet and the Corona Disease Anxiety Scale (CDAS) questionnaire were filled out by them. Fisher’s exact test, Mann-Whitney U and binary logistic regression tests were conducted for data analysis. Results: The results showed that out of 159 patients, 57.9% were female, with a mean age of 73.09 ± 9.64 years. The anxiety level of 70.4% of patients was mild or non-anxiety and 29.6% was moderate or severe. The correlation between anxiety related to COVID-19 with age, gender, vaccination status and history of being infected by COVID-19 was significant (P<0.05); however, the correlation with the job, place of residence and marital status were not significant (P>0.05). Conclusion: We concluded that older age, female gender, non-vaccinated and having no history of being infected by COVID-19 are the most influential factors that increase anxiety triggered by COVID-19 in elderly patients.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48826755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Abbas Rezaei Naserabad, Shahram Bagheri, P. Kheradmand, S. Latifi
Introduction: Breast cancer (BC) is the most common cancer in women, which is the second most common malignancy in terms of mortality and prevalence after lung cancer. BC is a group of very diverse diseases that can be detected at a molecular, histopathological and clinical level. Objectives: The aim of the present study was to evaluate the expression of CK5/6 and its relationship to some of the factors affecting prognosis, such as tumor grade, lymph node involvement. Patients and Methods: In this cross-sectional study with descriptive and analytical aspects, 40 malignant and 20 benign tumors were collected in 2020 from the archives of the pathology department of two educational hospitals in the city of Ahvaz. The demographic and clinical characteristics of each specimen, including age, patient, lymphovascular and perineural invasion, lymph node involvement, tumor grade and tumor type were extracted from the patients’ record. Then the expression of CK5/6 intensity staining was examined by immunohistochemistry. Results: All benign breast lesions had positive expression for CK5/6 and staining intensity between six and nine. In the malignant group, 33 samples showed negative expression of CK5/6 and only seven samples (17.5%) showed positive expression with a low-staining index. A positive expression with a low-staining index. All seven positive specimens were invasive ductal carcinoma (IDC) lesions with staining index 2, 4, and 6. Additionally, none of the ductal carcinoma in situ (DCIS) specimens which immunostained were positive for CK5/6. In the present study, all IDCs with weak expression of CK5/6 were grade III. No statistically significant relationship was observed between perineural and lymphovascular invasion and lymph node involvement with the intensity of CK5/6 expression. Conclusion: Our study showed that cytokeratin immunohistochemical intensity is able to distinguish benign lesions from malignant IDC and DCIS lesions and accordingly in determining of tumor grade after weak staining in high-grade IDC, which may be due to squamous metaplasia in these tumors; however, more extensive research with a larger sample size are required to assess its effect in lymphovascular and perineural invasion and also lymph node involvement.
{"title":"Investigating the expression of cytokeratin 5/6 in benign and malignant breast lesions","authors":"Seyed Abbas Rezaei Naserabad, Shahram Bagheri, P. Kheradmand, S. Latifi","doi":"10.34172/ipp.2023.39477","DOIUrl":"https://doi.org/10.34172/ipp.2023.39477","url":null,"abstract":"Introduction: Breast cancer (BC) is the most common cancer in women, which is the second most common malignancy in terms of mortality and prevalence after lung cancer. BC is a group of very diverse diseases that can be detected at a molecular, histopathological and clinical level. Objectives: The aim of the present study was to evaluate the expression of CK5/6 and its relationship to some of the factors affecting prognosis, such as tumor grade, lymph node involvement. Patients and Methods: In this cross-sectional study with descriptive and analytical aspects, 40 malignant and 20 benign tumors were collected in 2020 from the archives of the pathology department of two educational hospitals in the city of Ahvaz. The demographic and clinical characteristics of each specimen, including age, patient, lymphovascular and perineural invasion, lymph node involvement, tumor grade and tumor type were extracted from the patients’ record. Then the expression of CK5/6 intensity staining was examined by immunohistochemistry. Results: All benign breast lesions had positive expression for CK5/6 and staining intensity between six and nine. In the malignant group, 33 samples showed negative expression of CK5/6 and only seven samples (17.5%) showed positive expression with a low-staining index. A positive expression with a low-staining index. All seven positive specimens were invasive ductal carcinoma (IDC) lesions with staining index 2, 4, and 6. Additionally, none of the ductal carcinoma in situ (DCIS) specimens which immunostained were positive for CK5/6. In the present study, all IDCs with weak expression of CK5/6 were grade III. No statistically significant relationship was observed between perineural and lymphovascular invasion and lymph node involvement with the intensity of CK5/6 expression. Conclusion: Our study showed that cytokeratin immunohistochemical intensity is able to distinguish benign lesions from malignant IDC and DCIS lesions and accordingly in determining of tumor grade after weak staining in high-grade IDC, which may be due to squamous metaplasia in these tumors; however, more extensive research with a larger sample size are required to assess its effect in lymphovascular and perineural invasion and also lymph node involvement.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45950884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Soheilipour, Amir Aria, M. Momenzadeh, Elham Tabesh, Peyman Adibi Sedeh
Introduction: Ineffective esophageal motility (IEM) is an esophageal motility disorder (EMD) and the most prevalent abnormality routinely observed in esophageal manometry. Objectives: In this study, we investigated the clinical characteristics of IEM patients and the effects of proton pump inhibitors (PPI) and surgical treatments on their conditions. Patients and Methods: This cross-sectional study was conducted in Isfahan in 2019-2020 on 40 patients diagnosed with IEM. We collected patient demographic information (age, gender, previous medical history, medications, and duration of the current problem) and clinical manifestations (clinical symptoms of patients including dysphagia, heartburn, food and acid regurgitation, chest pain and belching) prior to and following PPI or surgical treatment. Results: Approximately 65% of patients presented with dysphagia and heartburn, 55% had food and acid regurgitation, 47.5% had belching, and 55% had chest pain. Post-treatment findings revealed that only the recurrence of food and acid regurgitation was significantly lower in the PPI treatment group than in the surgical group. Only dysphagia severity was statistically significant in the surgical group compared to other symptoms (P=0.042). In the PPI group, the severity of heartburn (P=0.007), dysphagia (P<0.001), food and acid regurgitation (P=0.007), and chest pain (P=0.027) decreased significantly compared to baseline. Conclusion: This study showed that the common clinical manifestations of IEM were dysphagia, heartburn, food and acid regurgitation, and belching. Moreover, treatment with PPI resulted in more significant improvements than surgical treatment.
{"title":"Clinical features, endoscopic and manometric findings in patients with ineffective esophageal motility","authors":"M. Soheilipour, Amir Aria, M. Momenzadeh, Elham Tabesh, Peyman Adibi Sedeh","doi":"10.34172/ipp.2023.39451","DOIUrl":"https://doi.org/10.34172/ipp.2023.39451","url":null,"abstract":"Introduction: Ineffective esophageal motility (IEM) is an esophageal motility disorder (EMD) and the most prevalent abnormality routinely observed in esophageal manometry. Objectives: In this study, we investigated the clinical characteristics of IEM patients and the effects of proton pump inhibitors (PPI) and surgical treatments on their conditions. Patients and Methods: This cross-sectional study was conducted in Isfahan in 2019-2020 on 40 patients diagnosed with IEM. We collected patient demographic information (age, gender, previous medical history, medications, and duration of the current problem) and clinical manifestations (clinical symptoms of patients including dysphagia, heartburn, food and acid regurgitation, chest pain and belching) prior to and following PPI or surgical treatment. Results: Approximately 65% of patients presented with dysphagia and heartburn, 55% had food and acid regurgitation, 47.5% had belching, and 55% had chest pain. Post-treatment findings revealed that only the recurrence of food and acid regurgitation was significantly lower in the PPI treatment group than in the surgical group. Only dysphagia severity was statistically significant in the surgical group compared to other symptoms (P=0.042). In the PPI group, the severity of heartburn (P=0.007), dysphagia (P<0.001), food and acid regurgitation (P=0.007), and chest pain (P=0.027) decreased significantly compared to baseline. Conclusion: This study showed that the common clinical manifestations of IEM were dysphagia, heartburn, food and acid regurgitation, and belching. Moreover, treatment with PPI resulted in more significant improvements than surgical treatment.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44041140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death, worldwide. Objectives: This study aimed to evaluate the CD133 expression rate in colon cancers and determine its relationship with colon cancer prognosis. Patients and Methods: This cross-sectional study was conducted in AL-Zahra hospital in Isfahan from April 2008 to April 2014 on 80 patients with CRC. In this study demographic profile such as age and gender, clinicopathologic profile including tumor grade, size, stage, metastasis, 5-year survival and their relation with CD133 expression in form of diffuse, weakly and negative were investigated. Results: From the 80 investigated patients, 47 (58.8%) were male and rest were female. The most common type of CD133 was diffuse type with the 43.8% of cases. Mean age of patients was 61.4 ±14.12 years. This study showed a significant difference between type of CD133 in regards of tumour size (from 23.11 mm in negative cases to 38.85 in weakly cases, P = 0.047). Moreover, the 5-year survival in the three groups of CD133 were significantly different (from 22.54 months in diffuse to 34.42 months in negative cases, P = 0.025). Conclusion: CD133 may be considered as an important tumor marker and a prognostic and diagnostic marker, as well as a therapeutic approach in patients with CRC.
{"title":"Evaluation of CD133 expression rate in colon cancers with immunohistochemistry method and its relationship with colon cancer prognosis","authors":"MH. Sanei, Tina Foodeh, M. Sanei","doi":"10.34172/ipp.2023.35458","DOIUrl":"https://doi.org/10.34172/ipp.2023.35458","url":null,"abstract":"Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death, worldwide. Objectives: This study aimed to evaluate the CD133 expression rate in colon cancers and determine its relationship with colon cancer prognosis. Patients and Methods: This cross-sectional study was conducted in AL-Zahra hospital in Isfahan from April 2008 to April 2014 on 80 patients with CRC. In this study demographic profile such as age and gender, clinicopathologic profile including tumor grade, size, stage, metastasis, 5-year survival and their relation with CD133 expression in form of diffuse, weakly and negative were investigated. Results: From the 80 investigated patients, 47 (58.8%) were male and rest were female. The most common type of CD133 was diffuse type with the 43.8% of cases. Mean age of patients was 61.4 ±14.12 years. This study showed a significant difference between type of CD133 in regards of tumour size (from 23.11 mm in negative cases to 38.85 in weakly cases, P = 0.047). Moreover, the 5-year survival in the three groups of CD133 were significantly different (from 22.54 months in diffuse to 34.42 months in negative cases, P = 0.025). Conclusion: CD133 may be considered as an important tumor marker and a prognostic and diagnostic marker, as well as a therapeutic approach in patients with CRC.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43097763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Fakhri, H. Azadeh, A. Jokar, M. Moosazadeh, H. Fakheri, Melina Ramezanpour
Introduction: Rheumatoid arthritis is a chronic autoimmune disease with numerous side effects. Since long ago, the impact of fish consumption on treating this disease has been of researchers’ interest. Hence, this study aims to examine the relationship between fish consumption and the risk of rheumatoid arthritis through a systematic review and a meta-analysis method. Materials and Methods: For this meta-analysis to reach the research related to the case study, the following databases: PubMed, Scopus, Web of Science, Cochrane, and the Google Scholar search engine were conducted. The data were analyzed using the STATA 14, and the significance level of the tests was P <0.05. Results: There were 2166980 people (20218 cases and 2146762 controls) in this case study, and the age range of the patients was between 18 and 89. The studies were published between 1991 and 2022 and estimated the odds ratio (OR) of fish consumption and rheumatoid arthritis as (OR =0.83; 95% CI: 0.78, 0.89). This measure was (OR =0.79; 95% CI: 0.72, 0.87) in six case-control studies and (OR =0.86; 95% CI: 0.78, 0.94) in 7 cohort studies. In addition, the effect of fish consumption on reducing the rheumatoid arthritis development was more in people who had consumed fish 2 or less than 2 times a week compared to people who consumed fish more than 2 times every week. Conclusion: Fish consumption reduces the rheumatoid arthritis extension; therefore, these patients are advised to include fish in their diet.
简介：类风湿性关节炎是一种慢性自身免疫性疾病，有许多副作用。很久以前，研究人员就对食用鱼类对治疗这种疾病的影响感兴趣。因此，本研究旨在通过系统综述和荟萃分析方法来检验鱼类消费与类风湿性关节炎风险之间的关系。材料和方法：为了达到与案例研究相关的研究，本荟萃分析使用了以下数据库：PubMed、Scopus、Web of Science、Cochrane和Google Scholar搜索引擎。使用STATA14对数据进行分析，测试的显著性水平为P<0.05。结果：本病例研究共有2166980人（20218例和2146762例对照），患者年龄范围在18至89岁之间。这些研究发表于1991年至2022年，估计鱼类消费与类风湿性关节炎的比值比（OR）为（OR=0.83；95%CI:0.78，0.89）。在6项病例对照研究中，这一指标为（OR=779；95%CI:0.72，0.87），在7项队列研究中为（OR=886；95%CI:0.98，0.94）。此外，与每周食用鱼类超过2次的人相比，每周食用鱼类2次或2次以下的人食用鱼类对减少类风湿性关节炎发展的影响更大。结论：食用鱼类可减少类风湿性关节炎的扩展；因此，建议这些患者在饮食中加入鱼类。
{"title":"The relationship between fish consumption and Rheumatoid Arthritis: a systematic review and meta-analysis","authors":"M. Fakhri, H. Azadeh, A. Jokar, M. Moosazadeh, H. Fakheri, Melina Ramezanpour","doi":"10.34172/ipp.2023.36452","DOIUrl":"https://doi.org/10.34172/ipp.2023.36452","url":null,"abstract":"Introduction: Rheumatoid arthritis is a chronic autoimmune disease with numerous side effects. Since long ago, the impact of fish consumption on treating this disease has been of researchers’ interest. Hence, this study aims to examine the relationship between fish consumption and the risk of rheumatoid arthritis through a systematic review and a meta-analysis method. Materials and Methods: For this meta-analysis to reach the research related to the case study, the following databases: PubMed, Scopus, Web of Science, Cochrane, and the Google Scholar search engine were conducted. The data were analyzed using the STATA 14, and the significance level of the tests was P <0.05. Results: There were 2166980 people (20218 cases and 2146762 controls) in this case study, and the age range of the patients was between 18 and 89. The studies were published between 1991 and 2022 and estimated the odds ratio (OR) of fish consumption and rheumatoid arthritis as (OR =0.83; 95% CI: 0.78, 0.89). This measure was (OR =0.79; 95% CI: 0.72, 0.87) in six case-control studies and (OR =0.86; 95% CI: 0.78, 0.94) in 7 cohort studies. In addition, the effect of fish consumption on reducing the rheumatoid arthritis development was more in people who had consumed fish 2 or less than 2 times a week compared to people who consumed fish more than 2 times every week. Conclusion: Fish consumption reduces the rheumatoid arthritis extension; therefore, these patients are advised to include fish in their diet.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43909441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hanieh Raji, S. Borsi, Z. Mehraban, Sahar Azizi Moghadam
Introduction: Long-term pulmonary consequences of coronavirus disease 2019 (COVID-19) are unknown. Objectives: The aim of this study was the clinical and radiologic consequences and pulmonary function test in the cured COVID-19 patients in a three-month follow-up. Patients and Methods: Patients with laboratory-confirmed COVID-19 infection by a reverse transcription polymerase chain reaction (RT-PCR) assay were recruited in this prospective descriptive epidemiological study. Computerized tomography (CT) scan and blood oxygen measurement were performed before and three months after discharge for all the patients. Spirometry test and 6-minute walk test (6MWT) were conducted to determine the levels of dyspnea and persistent respiratory symptoms. Results: Eighty patients were recruited in this study. At the 3-month follow-up, oxygen saturation was higher than the time of discharge from the hospital. Chest CT scan showed abnormal results in 66.3% of patients. The pulmonary function test results indicated that only 27 (35.75%) of patients had abnormal test. The median distance in the 6MWT was 325 meters (interquartile range, 96-480 m). Conclusion: Follow-up of COVID-19 patients revealed radiological abnormalities in most cured COVID-19 patients, indicating the need for more extended follow-up periods for investigating the long-term consequences of COVID-19.
{"title":"Clinical, radiological outcomes and pulmonary function tests in patients recovered from COVID-19 in a three-month follow-up","authors":"Hanieh Raji, S. Borsi, Z. Mehraban, Sahar Azizi Moghadam","doi":"10.34172/ipp.2023.31362","DOIUrl":"https://doi.org/10.34172/ipp.2023.31362","url":null,"abstract":"Introduction: Long-term pulmonary consequences of coronavirus disease 2019 (COVID-19) are unknown. Objectives: The aim of this study was the clinical and radiologic consequences and pulmonary function test in the cured COVID-19 patients in a three-month follow-up. Patients and Methods: Patients with laboratory-confirmed COVID-19 infection by a reverse transcription polymerase chain reaction (RT-PCR) assay were recruited in this prospective descriptive epidemiological study. Computerized tomography (CT) scan and blood oxygen measurement were performed before and three months after discharge for all the patients. Spirometry test and 6-minute walk test (6MWT) were conducted to determine the levels of dyspnea and persistent respiratory symptoms. Results: Eighty patients were recruited in this study. At the 3-month follow-up, oxygen saturation was higher than the time of discharge from the hospital. Chest CT scan showed abnormal results in 66.3% of patients. The pulmonary function test results indicated that only 27 (35.75%) of patients had abnormal test. The median distance in the 6MWT was 325 meters (interquartile range, 96-480 m). Conclusion: Follow-up of COVID-19 patients revealed radiological abnormalities in most cured COVID-19 patients, indicating the need for more extended follow-up periods for investigating the long-term consequences of COVID-19.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47570147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoumeh Faramarzi, A. Khorramdel, A. Babaloo, M. Sadighi, Ali Sadaghian
Introduction: Cytokines play a prominent role in the induction of periodontal diseases. Aloe vera can ameliorate periodontal disease considering its anti-inflammatory and antibacterial effects. Objectives: This study investigated the effect of topical aloe vera gel, associated with scaling and root planing (SRP), on interleukin-1 (IL-1) and interleukin-17 (IL-17) of gingival crevicular fluid (GCF) levels in chronic periodontitis patients. Patients and Methods: This study recruited 20 patients diagnosed with moderate to severe chronic periodontitis (with probing pocket depths of ≥5 mm). The control group subjects underwent only SRP; the test group subjects underwent SRP, followed by topical aloe vera gel application. Periodontal clinical parameters, including probing depth (PD), clinical attachment level (CAL) and gingival index (GI), were determined; GCF levels of IL-1 and IL-17 were determined using the enzyme-linked immunosorbent assay (ELISA) at baseline and one month postoperatively. Results: There were significant decreases in periodontal clinical parameters in both groups compared to the baseline. The test group exhibited a significant decrease in interleukin levels compared with the control group as follows; interleukin-1 beta (IL-1β) (control; 61.78±14.54, test; 43.06±10.99 ng/mL) (P<0.001), IL-17 (control; 81.33±16.66, test; 57.04±16.26 ng/mL) (P<0.001). Conclusion: Topical aloe vera gel in combination with SRP significantly improved clinical parameters of periodontitis and decreased IL-1β and IL-17 GCF levels. Trial Registration: The trial protocol of the present study was approved by the Iranian registry of Clinical Trials (identifier: IRCT20100412003690N11; https://en.irct.ir/trial/44975; ethical code #IR.TBZMED.REC.1398.1113).
{"title":"Effect of topical aloe vera gel on gingival crevicular fluid interleukin-1 beta and interleukin-17 levels in patients with chronic periodontitis; A double-blind split-mouth randomized clinical trial","authors":"Masoumeh Faramarzi, A. Khorramdel, A. Babaloo, M. Sadighi, Ali Sadaghian","doi":"10.34172/ipp.2023.34426","DOIUrl":"https://doi.org/10.34172/ipp.2023.34426","url":null,"abstract":"Introduction: Cytokines play a prominent role in the induction of periodontal diseases. Aloe vera can ameliorate periodontal disease considering its anti-inflammatory and antibacterial effects. Objectives: This study investigated the effect of topical aloe vera gel, associated with scaling and root planing (SRP), on interleukin-1 (IL-1) and interleukin-17 (IL-17) of gingival crevicular fluid (GCF) levels in chronic periodontitis patients. Patients and Methods: This study recruited 20 patients diagnosed with moderate to severe chronic periodontitis (with probing pocket depths of ≥5 mm). The control group subjects underwent only SRP; the test group subjects underwent SRP, followed by topical aloe vera gel application. Periodontal clinical parameters, including probing depth (PD), clinical attachment level (CAL) and gingival index (GI), were determined; GCF levels of IL-1 and IL-17 were determined using the enzyme-linked immunosorbent assay (ELISA) at baseline and one month postoperatively. Results: There were significant decreases in periodontal clinical parameters in both groups compared to the baseline. The test group exhibited a significant decrease in interleukin levels compared with the control group as follows; interleukin-1 beta (IL-1β) (control; 61.78±14.54, test; 43.06±10.99 ng/mL) (P<0.001), IL-17 (control; 81.33±16.66, test; 57.04±16.26 ng/mL) (P<0.001). Conclusion: Topical aloe vera gel in combination with SRP significantly improved clinical parameters of periodontitis and decreased IL-1β and IL-17 GCF levels. Trial Registration: The trial protocol of the present study was approved by the Iranian registry of Clinical Trials (identifier: IRCT20100412003690N11; https://en.irct.ir/trial/44975; ethical code #IR.TBZMED.REC.1398.1113).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42769213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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