Background: Diabetes mellitus is a metabolite disorder with parameters of high blood sugar levels. In the management of diabetes can be used the drug metformin is the gold of choice to achieve a therapeutic effect and rarely causes side effects of the drug, but it still has debate view. However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis. Objective: This study aims to evaluate the side effect of metformin for diabetic kidney disease (DKD) patients. Methods: This study used the Narrative Review Method that was obtained from 2011 to 2021, in the English language from PubMed, Google Scholar, and Cochrane Library. Results: Metformin is at the forefront of the treatment of type 2 diabetes mellitus (DM2). Metformin is likely to have lactic acidosis-related adverse effects in chronic kidney disease (CKD) patients, such as increased arterial lactate. Lactic acidosis is defined as an increase in arterial lactate with an indicator of more than five mmol/L and an arterial blood pH of less than 7.35. Metformin-induced lactate levels are below the parameters. DKD risk factors can be conceptually classified as several susceptibility factors, initiation factors, and developmental factors. The two most prominent risk factors are hyperglycemia and hypertension. Conclusion: Metformin can increase lactate levels in CKD patients but is still below the parameters of lactic acidosis. This study may have some weaknesses and requires further prospective research to validate the results.
{"title":"Lactic acidosis associated with metformin in patients with diabetic kidney disease; a mini-review","authors":"Fatkhu Rahman, S. Tuba","doi":"10.34172/ipp.2023.34450","DOIUrl":"https://doi.org/10.34172/ipp.2023.34450","url":null,"abstract":"Background: Diabetes mellitus is a metabolite disorder with parameters of high blood sugar levels. In the management of diabetes can be used the drug metformin is the gold of choice to achieve a therapeutic effect and rarely causes side effects of the drug, but it still has debate view. However, if used in excessive doses for patients with kidney disease, it will be contraindicated with side effects such as lactic acidosis. Objective: This study aims to evaluate the side effect of metformin for diabetic kidney disease (DKD) patients. Methods: This study used the Narrative Review Method that was obtained from 2011 to 2021, in the English language from PubMed, Google Scholar, and Cochrane Library. Results: Metformin is at the forefront of the treatment of type 2 diabetes mellitus (DM2). Metformin is likely to have lactic acidosis-related adverse effects in chronic kidney disease (CKD) patients, such as increased arterial lactate. Lactic acidosis is defined as an increase in arterial lactate with an indicator of more than five mmol/L and an arterial blood pH of less than 7.35. Metformin-induced lactate levels are below the parameters. DKD risk factors can be conceptually classified as several susceptibility factors, initiation factors, and developmental factors. The two most prominent risk factors are hyperglycemia and hypertension. Conclusion: Metformin can increase lactate levels in CKD patients but is still below the parameters of lactic acidosis. This study may have some weaknesses and requires further prospective research to validate the results.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46275992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigating the role of CD44 expression in the survival of colorectal cancer patients","authors":"MH. Sanei, Maryam Malekmohammad, M. Sanei","doi":"10.34172/ipp.2023.38452","DOIUrl":"https://doi.org/10.34172/ipp.2023.38452","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44873340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Nestin plays a significant role in diagnosis, prognosis, clinical course and/or response to the treatment. Previous studies have investigated the nestin expression in melanoma, however a limited number have focused on basal cell carcinoma (BCC) and basosquamous carcinoma (BSC). Objectives: The current study aimed to investigate nestin expression in melanoma, BCC, and BSC. Materials and Methods: This cross-sectional study was conducted on 40 melanomas, 40 BCC and 40 BSC specimens. Tumor size, lesion location and stage of disease were recorded. Then, nestin staining was conducted in all the present samples, then the amount of nestin expression was assessed. Results: According to the results of this study, nestin was expressed in all melanoma specimens; while it was expressed in 15% of BSC and 25% of BCC specimens. The mean score of nestin expression in melanoma specimens (0.85 ± 2.50) was significantly higher than the BSC and BCC specimens with the means of 0.36±0.15 and 0.44±0.25 respectively (P value <0.001). However, there was no significant difference between BSC and BCC specimens in nestin expression. Additionally, in the melanoma specimens, a significant and direct relationship between nestin expression and the various stages of melanoma with the coefficient of 0.345 (P value = 0.025). Conclusion: The results of the current study showed that expression of nestin could have a good prognostic value in skin melanoma while, there is a significant relationship with its progression. However, in non-melanoma specimens, no distinction can be detected regarding the nestin expression.
{"title":"Evaluation of nestin expression in melanoma, basal cell carcinoma and basosquamous carcinoma","authors":"M. Mokhtari, Negar Safari","doi":"10.34172/ipp.2023.34431","DOIUrl":"https://doi.org/10.34172/ipp.2023.34431","url":null,"abstract":"Introduction: Nestin plays a significant role in diagnosis, prognosis, clinical course and/or response to the treatment. Previous studies have investigated the nestin expression in melanoma, however a limited number have focused on basal cell carcinoma (BCC) and basosquamous carcinoma (BSC). Objectives: The current study aimed to investigate nestin expression in melanoma, BCC, and BSC. Materials and Methods: This cross-sectional study was conducted on 40 melanomas, 40 BCC and 40 BSC specimens. Tumor size, lesion location and stage of disease were recorded. Then, nestin staining was conducted in all the present samples, then the amount of nestin expression was assessed. Results: According to the results of this study, nestin was expressed in all melanoma specimens; while it was expressed in 15% of BSC and 25% of BCC specimens. The mean score of nestin expression in melanoma specimens (0.85 ± 2.50) was significantly higher than the BSC and BCC specimens with the means of 0.36±0.15 and 0.44±0.25 respectively (P value <0.001). However, there was no significant difference between BSC and BCC specimens in nestin expression. Additionally, in the melanoma specimens, a significant and direct relationship between nestin expression and the various stages of melanoma with the coefficient of 0.345 (P value = 0.025). Conclusion: The results of the current study showed that expression of nestin could have a good prognostic value in skin melanoma while, there is a significant relationship with its progression. However, in non-melanoma specimens, no distinction can be detected regarding the nestin expression.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47651381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masood Zadkarami, Foroozan Rahimpour, A. Hardani, H. Javaherizadeh
Introduction: Recently ursodeoxycholic acid was recommended for the treatment of neonatal hyperbilirubinemia in a few studies. Objectives: This study aimed to compare ursodeoxycholic acid and phototherapy versus phototherapy in lowering the level of bilirubin in neonates who was admitted due to hyperbilirubinemia. Patients and Methods: This randomized double-blind study was carried out in the department of neonatology at the children’s medical center of Ahvaz Jundishapur of the University of Medical Sciences. Inclusion criteria were weight 2500-4200 g and exclusive breastfeeding. Gestational age between 38-41 weeks and age between 3-7 days were included. Total bilirubin between 14-20 according to Bhutani nomogram and direct bilirubin was less than 2 mg/dl was included. Exclusion criteria were ABO incompatibility, Rh incompatibility, G6PD (glucose6-phosphate dehydrogenase) deficiency, sepsis, hypothyroidism, liver problem, prematurity and newborn of diabetic mothers. A dose of 5 mg/kg per dose of ursodeoxycholic acid (UDCA) was prescribed for neonates every 12 hours. Placebo is also prescribed for other neonates. Unconjugated bilirubin was measured after 4 hours and every 12 hours till total bilirubin=12 mg/dL. The primary outcome measures were total bilirubin level four hours and every 12 hours after admission till reached 12 mg/dL. The secondary outcome measure was total bilirubin=12 mg/dL at 12-24 hours after admission and diarrhea, vomiting, skin rash or any adverse effect in the neonates who received UDCA. Neonates who underwent phototherapy and UDCA were the case group. Neonates who received phototherapy and placebo were allocated in the control group. Data were analyzed using SPSS version 16.0. Kolmogorov-Smirnov test was conducted to evaluate data distribution. Intention-to-treat analysis was used. Mann-Whitney U test was conducted for data analysis. Results: In the current study, 30 cases and 30 control were included. Discharged neonates were 96% among the UDCA group and 87% among the control group in the 1st 24 hours after admission. Among the UDCA group, 100% were discharged at the 2nd 24 hours of admission and 96% among the control. The duration of phototherapy was shorter in the case group than in the control group, however this difference had no statistical difference. Conclusion: No significant difference between neonates who underwent phototherapy and phototherapy+ UDCA in terms of duration of phototherapy and bilirubin reduction was found. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20181003041225N1; https://en.irct.ir/trial/34272, ethical code; IR.AJUMS.REC.1397.899).
{"title":"Ursodeoxycholic acid and phototherapy versus phototherapy and placebo on neonatal indirect hyperbilirubinemia","authors":"Masood Zadkarami, Foroozan Rahimpour, A. Hardani, H. Javaherizadeh","doi":"10.34172/ipp.2023.35457","DOIUrl":"https://doi.org/10.34172/ipp.2023.35457","url":null,"abstract":"Introduction: Recently ursodeoxycholic acid was recommended for the treatment of neonatal hyperbilirubinemia in a few studies. Objectives: This study aimed to compare ursodeoxycholic acid and phototherapy versus phototherapy in lowering the level of bilirubin in neonates who was admitted due to hyperbilirubinemia. Patients and Methods: This randomized double-blind study was carried out in the department of neonatology at the children’s medical center of Ahvaz Jundishapur of the University of Medical Sciences. Inclusion criteria were weight 2500-4200 g and exclusive breastfeeding. Gestational age between 38-41 weeks and age between 3-7 days were included. Total bilirubin between 14-20 according to Bhutani nomogram and direct bilirubin was less than 2 mg/dl was included. Exclusion criteria were ABO incompatibility, Rh incompatibility, G6PD (glucose6-phosphate dehydrogenase) deficiency, sepsis, hypothyroidism, liver problem, prematurity and newborn of diabetic mothers. A dose of 5 mg/kg per dose of ursodeoxycholic acid (UDCA) was prescribed for neonates every 12 hours. Placebo is also prescribed for other neonates. Unconjugated bilirubin was measured after 4 hours and every 12 hours till total bilirubin=12 mg/dL. The primary outcome measures were total bilirubin level four hours and every 12 hours after admission till reached 12 mg/dL. The secondary outcome measure was total bilirubin=12 mg/dL at 12-24 hours after admission and diarrhea, vomiting, skin rash or any adverse effect in the neonates who received UDCA. Neonates who underwent phototherapy and UDCA were the case group. Neonates who received phototherapy and placebo were allocated in the control group. Data were analyzed using SPSS version 16.0. Kolmogorov-Smirnov test was conducted to evaluate data distribution. Intention-to-treat analysis was used. Mann-Whitney U test was conducted for data analysis. Results: In the current study, 30 cases and 30 control were included. Discharged neonates were 96% among the UDCA group and 87% among the control group in the 1st 24 hours after admission. Among the UDCA group, 100% were discharged at the 2nd 24 hours of admission and 96% among the control. The duration of phototherapy was shorter in the case group than in the control group, however this difference had no statistical difference. Conclusion: No significant difference between neonates who underwent phototherapy and phototherapy+ UDCA in terms of duration of phototherapy and bilirubin reduction was found. Trial Registration: The trial protocol was approved by the Iranian Registry of Clinical Trials (identifier: IRCT20181003041225N1; https://en.irct.ir/trial/34272, ethical code; IR.AJUMS.REC.1397.899).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44480179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mousavi, Shahin Asgari Savadjani, H. Karimzadeh, Bahram Pakzad, Mansour Salesi
Introduction: Type 2 diabetes mellitus (T2DM) increases the risk of bone fractures. Objectives: This study aimed to examine the use of trabecular bone score (TBS) and BMD to select the best diagnostic tool for osteoporosis caused by type 2 diabetes. Patients and Methods: One hundred and four patients (52 individuals with type 2 diabetes and 52 ones without diabetes) aged at most 50 years were enrolled in a cross-sectional study that was conducted with dual-energy X-ray absorptiometry (DXA) images of patients referred to Khorshid and Al-Zahra hospitals, Isfahan, Iran. Results: Lumbosacral bone mineral density (BMD) was significantly lower in the diabetic group than in the control group (0.76 versus 0.82, P=0.041). The mean lumbosacral TBS was significantly lower in the diabetic group than in the controls (1.24 versus 1.36, P=0.001). Therefore, the lumbosacral TBS provided a more reliable indicator than lumbosacral BMD to discriminate between controls and women with T2DM. Conclusion: The TBS is recommended for early diagnosis of osteoporosis in diabetic patients because of its independence from BMD-related parameters. The TBS can capture a larger portion of the bone deterioration in women with T2DM that cannot be detected using methods based solely on BMD.
2型糖尿病(T2DM)增加骨折的风险。目的:本研究旨在探讨使用骨小梁评分(TBS)和骨密度(BMD)来选择2型糖尿病所致骨质疏松的最佳诊断工具。患者和方法:104名年龄不超过50岁的患者(52名2型糖尿病患者和52名非糖尿病患者)参加了一项横断面研究，该研究采用伊朗伊斯法罕Khorshid和Al-Zahra医院患者的双能x射线吸收仪(DXA)图像进行。结果:糖尿病组腰骶骨骨密度(BMD)明显低于对照组(0.76比0.82,P=0.041)。糖尿病组腰骶部平均TBS显著低于对照组(1.24 vs 1.36, P=0.001)。因此，腰骶部TBS比腰骶部BMD提供了一个更可靠的指标来区分对照组和女性T2DM。结论:TBS独立于bmd相关参数，可用于糖尿病骨质疏松症的早期诊断。TBS可以捕捉到T2DM患者骨退化的更大一部分，而仅基于BMD的方法无法检测到。
{"title":"Evaluation of bone mineral density and trabecular bone score for diagnosis of osteoporosis in Iranian diabetic patients","authors":"M. Mousavi, Shahin Asgari Savadjani, H. Karimzadeh, Bahram Pakzad, Mansour Salesi","doi":"10.34172/ipp.2023.34434","DOIUrl":"https://doi.org/10.34172/ipp.2023.34434","url":null,"abstract":"Introduction: Type 2 diabetes mellitus (T2DM) increases the risk of bone fractures. Objectives: This study aimed to examine the use of trabecular bone score (TBS) and BMD to select the best diagnostic tool for osteoporosis caused by type 2 diabetes. Patients and Methods: One hundred and four patients (52 individuals with type 2 diabetes and 52 ones without diabetes) aged at most 50 years were enrolled in a cross-sectional study that was conducted with dual-energy X-ray absorptiometry (DXA) images of patients referred to Khorshid and Al-Zahra hospitals, Isfahan, Iran. Results: Lumbosacral bone mineral density (BMD) was significantly lower in the diabetic group than in the control group (0.76 versus 0.82, P=0.041). The mean lumbosacral TBS was significantly lower in the diabetic group than in the controls (1.24 versus 1.36, P=0.001). Therefore, the lumbosacral TBS provided a more reliable indicator than lumbosacral BMD to discriminate between controls and women with T2DM. Conclusion: The TBS is recommended for early diagnosis of osteoporosis in diabetic patients because of its independence from BMD-related parameters. The TBS can capture a larger portion of the bone deterioration in women with T2DM that cannot be detected using methods based solely on BMD.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47594873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Firouzjahi, Karimollah Hajian Tilaki, Hossein Ghorbani, Nazila Shamsi Jamkhaneh, R. Akbari
Introduction: Chronic kidney disease (CKD) may increase morbidity and mortality. Therefore, early detection of inflammation in kidney transplant recipients with a high risk of transplant rejection is important. Objectives: This study was conducted to compare serum levels of pentraxin-3 (PTX-3), mannose binding lectin (MBL) and high sensitivity C-reactive protein (hs-CRP) in patients with chronic renal failure before and after transplantation. Patients and Methods: This cross-sectional study was carried on 18-80 years old patients receiving immunosuppressive therapy who underwent kidney transplantation in Shahid Beheshti hospital of Babol in 2016. Before transplantation, one week later and two months after transplantation, the serum levels of PTX-3, MBL and hs-CRP were determined. Complications including acute transplant rejection and urinary tract infection were recorded since inflammatory markers were evaluated and compared at the time of complication. Results: The mean age of the patients was 42.07±12.47 years. Transplant rejection and urinary tract infection occurred in 3 (10%) and 4 (13.3%) of patients, respectively. Patients over 55 years of age and those with hypertension had significantly more complications (P=0.03 and P=0.02 respectively). Two months after transplantation, PTX-3 and MBL levels were significantly lower (PTX-3; 10.84±15.88 versus18.75±24.31 ng/dL, P=0.001 and MBL; 764.3±771.35 versus 1157.9±1299.75 ng/dL, P=0.006). In patients with complications, PTX-3, MBL and hs-CRP levels were 16.73±27.98 ng/dL, 710.0±613.19 ng/dL and 8.43±12.10 mg/L, respectively. No significant difference was found between inflammatory markers in complicated and uncomplicated patients. Comparison of changes in PTX-3, MBL and hs-CRP levels before and after transplantation showed a significant difference two months following transplantation compared to pre-transplantation and also one week after it for PTX-3 and MBL (PTX-3: P=0.001 and P=0.009, respectively; MBL: P=0.006 and P=0.03, respectively). Conclusion: Based on the results of this study, PTX-3 and MBL levels can be considered for determining the inflammatory status of kidney transplant patients and the prognosis of transplantation.
慢性肾脏疾病(CKD)可增加发病率和死亡率。因此，早期发现有移植排斥风险的肾移植受者的炎症是很重要的。目的:本研究比较慢性肾功能衰竭患者移植前后血清戊曲辛-3 (PTX-3)、甘露糖结合凝集素(MBL)和高敏c反应蛋白(hs-CRP)水平。患者与方法:本横断面研究对象为2016年在巴博勒市Shahid Beheshti医院接受免疫抑制治疗的18-80岁肾移植患者。测定移植前、移植后1周、移植后2个月血清PTX-3、MBL、hs-CRP水平。并发症包括急性移植排斥反应和尿路感染，因为在并发症发生时评估和比较炎症标志物。结果:患者平均年龄42.07±12.47岁。移植排斥反应3例(10%)，尿路感染4例(13.3%)。55岁以上患者和高血压患者并发症发生率显著高于对照组(P=0.03, P=0.02)。移植后2个月，PTX-3和MBL水平显著降低(PTX-3;10.84±15.88 vs 18.75±24.31 ng/dL, P=0.001;764.3±771.35 vs 1157.9±1299.75 ng/dL, P=0.006)。并发症患者PTX-3、MBL、hs-CRP水平分别为16.73±27.98 ng/dL、710.0±613.19 ng/dL、8.43±12.10 mg/L。并发症与非并发症患者的炎症指标无显著差异。比较移植前后PTX-3、MBL和hs-CRP水平的变化，发现PTX-3和MBL在移植后2个月和1周与移植前比较有显著差异(PTX-3: P=0.001和P=0.009;MBL: P=0.006和P=0.03)。结论:基于本研究结果，PTX-3和MBL水平可作为判断肾移植患者炎症状态及移植预后的参考指标。
{"title":"Association between serum levels of pentraxin-3, mannose binding lectin and high sensitivity C-reactive protein with renal transplantation","authors":"A. Firouzjahi, Karimollah Hajian Tilaki, Hossein Ghorbani, Nazila Shamsi Jamkhaneh, R. Akbari","doi":"10.34172/ipp.2023.34419","DOIUrl":"https://doi.org/10.34172/ipp.2023.34419","url":null,"abstract":"Introduction: Chronic kidney disease (CKD) may increase morbidity and mortality. Therefore, early detection of inflammation in kidney transplant recipients with a high risk of transplant rejection is important. Objectives: This study was conducted to compare serum levels of pentraxin-3 (PTX-3), mannose binding lectin (MBL) and high sensitivity C-reactive protein (hs-CRP) in patients with chronic renal failure before and after transplantation. Patients and Methods: This cross-sectional study was carried on 18-80 years old patients receiving immunosuppressive therapy who underwent kidney transplantation in Shahid Beheshti hospital of Babol in 2016. Before transplantation, one week later and two months after transplantation, the serum levels of PTX-3, MBL and hs-CRP were determined. Complications including acute transplant rejection and urinary tract infection were recorded since inflammatory markers were evaluated and compared at the time of complication. Results: The mean age of the patients was 42.07±12.47 years. Transplant rejection and urinary tract infection occurred in 3 (10%) and 4 (13.3%) of patients, respectively. Patients over 55 years of age and those with hypertension had significantly more complications (P=0.03 and P=0.02 respectively). Two months after transplantation, PTX-3 and MBL levels were significantly lower (PTX-3; 10.84±15.88 versus18.75±24.31 ng/dL, P=0.001 and MBL; 764.3±771.35 versus 1157.9±1299.75 ng/dL, P=0.006). In patients with complications, PTX-3, MBL and hs-CRP levels were 16.73±27.98 ng/dL, 710.0±613.19 ng/dL and 8.43±12.10 mg/L, respectively. No significant difference was found between inflammatory markers in complicated and uncomplicated patients. Comparison of changes in PTX-3, MBL and hs-CRP levels before and after transplantation showed a significant difference two months following transplantation compared to pre-transplantation and also one week after it for PTX-3 and MBL (PTX-3: P=0.001 and P=0.009, respectively; MBL: P=0.006 and P=0.03, respectively). Conclusion: Based on the results of this study, PTX-3 and MBL levels can be considered for determining the inflammatory status of kidney transplant patients and the prognosis of transplantation.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44913243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Shirani, Elham Honarjou, B. Ataei, Sodabeh Rostami, Z. Nokhodian, Manijeh Shams
Introduction: Managing influenza (flu) due to its rapid transmission is a considerable challenge for the health system. Considering the variety of clinical symptoms in influenza and recognizing its symptoms in different conditions of patients can be effective in its management. Objectives: In the present cross-sectional study, we evaluate the relationship between clinical and para-clinical findings and the treatment measures observed at the time of hospitalization of influenza patients and their conditions at the time of discharge from the hospital. Patients and Methods: Our investigation was conducted from March 2019 to March 2021 in Alzahra hospital of Isfahan, Iran. The research population included influenza patients admitted to the infectious ward. Results: A total of 122 hospitalized influenza patients (n=122) were included in this research. The number of patients with influenza A and B was 44 and 78, respectively. There was a significant relationship between the type of influenza and the patient’s condition upon discharge (P=0.001). Influenza vaccination (P<0.001), diabetes (P=0.038), and cardiovascular disease (P=0.004) were significantly associated with the patient’s condition at discharge. According to our investigation, among the drugs used, oseltamivir significantly reduced mortality in patients receiving it (P<<0.001). There was a statistically significant difference between the variables of all chest radiology and the patient’s condition at the time of discharge (P<0.001). Furthermore, there was a statistically significant difference between the length of hospital stay (P=0.001), the number of white blood cells (P=0.001), the number of platelets (P=0.006), and the amount of C-reactive protein (CRP) (P<0.001) with the patient’s condition upon discharge. Conclusion: Among the comorbidities studied, diabetes and cardiovascular disease were significantly associated with mortality in patients with influenza. Vaccination significantly reduces mortality from influenza in high-risk patients. The antiviral drug oseltamivir is recommended as a useful drug for patients with the influenza. However, a multi-center study with larger sample size is necessary for a more conclusive result.
{"title":"Evaluation of clinical and para-clinical parameters related to disease severity and mortality in patients with influenza in Isfahan, Iran; a cross sectional study","authors":"K. Shirani, Elham Honarjou, B. Ataei, Sodabeh Rostami, Z. Nokhodian, Manijeh Shams","doi":"10.34172/ipp.2023.39462","DOIUrl":"https://doi.org/10.34172/ipp.2023.39462","url":null,"abstract":"Introduction: Managing influenza (flu) due to its rapid transmission is a considerable challenge for the health system. Considering the variety of clinical symptoms in influenza and recognizing its symptoms in different conditions of patients can be effective in its management. Objectives: In the present cross-sectional study, we evaluate the relationship between clinical and para-clinical findings and the treatment measures observed at the time of hospitalization of influenza patients and their conditions at the time of discharge from the hospital. Patients and Methods: Our investigation was conducted from March 2019 to March 2021 in Alzahra hospital of Isfahan, Iran. The research population included influenza patients admitted to the infectious ward. Results: A total of 122 hospitalized influenza patients (n=122) were included in this research. The number of patients with influenza A and B was 44 and 78, respectively. There was a significant relationship between the type of influenza and the patient’s condition upon discharge (P=0.001). Influenza vaccination (P<0.001), diabetes (P=0.038), and cardiovascular disease (P=0.004) were significantly associated with the patient’s condition at discharge. According to our investigation, among the drugs used, oseltamivir significantly reduced mortality in patients receiving it (P<<0.001). There was a statistically significant difference between the variables of all chest radiology and the patient’s condition at the time of discharge (P<0.001). Furthermore, there was a statistically significant difference between the length of hospital stay (P=0.001), the number of white blood cells (P=0.001), the number of platelets (P=0.006), and the amount of C-reactive protein (CRP) (P<0.001) with the patient’s condition upon discharge. Conclusion: Among the comorbidities studied, diabetes and cardiovascular disease were significantly associated with mortality in patients with influenza. Vaccination significantly reduces mortality from influenza in high-risk patients. The antiviral drug oseltamivir is recommended as a useful drug for patients with the influenza. However, a multi-center study with larger sample size is necessary for a more conclusive result.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49606334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farshad Gharebakhshi, Sara Abbasian, Mahsa Shariati Sough, E. Zaremoghadam, F. Zandiyeh, Golmis Abdolmohammadi, Aref Zarei, Zahra Tavassoli, A. Kalirad, M. Belali Kharaji
Introduction: Predicting factors related to the severity and mortality of coronavirus disease 2019 (COVID-19) patients can significantly help in better management of their treatment. Objectives: This study aimed to investigate the correlation between pulmonary radiologic findings based on the Warrick score and COVID-19 patients’ outcomes. Patients and Methods: This descriptive-analytical study was conducted on 436 COVID-19 patients hospitalized at Shahid Mohammadi hospital in Bandar Abbas. Pulmonary radiologic findings were scored based on the Warrick score. Outcomes of COVID-19 patients, including disease severity and mortality, were followed. Independent T-test and binary logistic regression were conducted to explore the correlation between the pulmonary radiologic findings and patients’ outcomes. Results: Results showed that the correlation between pulmonary radiologic findings with both disease severity and mortality was significant, since higher pulmonary involvement caused greater severity and mortality. The Warrick score difference between dead and recovered patients and low and high disease severity were significant, therefore greater Warrick score caused more disease severity and mortality. Conclusion: Pulmonary radiologic findings based on the Warrick score can use as a predictor of COVID-19 patients’ outcomes.
{"title":"Pulmonary radiologic findings based on Warrick score as a predictor of COVID-19 patients’ outcomes","authors":"Farshad Gharebakhshi, Sara Abbasian, Mahsa Shariati Sough, E. Zaremoghadam, F. Zandiyeh, Golmis Abdolmohammadi, Aref Zarei, Zahra Tavassoli, A. Kalirad, M. Belali Kharaji","doi":"10.34172/ipp.2023.39459","DOIUrl":"https://doi.org/10.34172/ipp.2023.39459","url":null,"abstract":"Introduction: Predicting factors related to the severity and mortality of coronavirus disease 2019 (COVID-19) patients can significantly help in better management of their treatment. Objectives: This study aimed to investigate the correlation between pulmonary radiologic findings based on the Warrick score and COVID-19 patients’ outcomes. Patients and Methods: This descriptive-analytical study was conducted on 436 COVID-19 patients hospitalized at Shahid Mohammadi hospital in Bandar Abbas. Pulmonary radiologic findings were scored based on the Warrick score. Outcomes of COVID-19 patients, including disease severity and mortality, were followed. Independent T-test and binary logistic regression were conducted to explore the correlation between the pulmonary radiologic findings and patients’ outcomes. Results: Results showed that the correlation between pulmonary radiologic findings with both disease severity and mortality was significant, since higher pulmonary involvement caused greater severity and mortality. The Warrick score difference between dead and recovered patients and low and high disease severity were significant, therefore greater Warrick score caused more disease severity and mortality. Conclusion: Pulmonary radiologic findings based on the Warrick score can use as a predictor of COVID-19 patients’ outcomes.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45920397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bahareh Abrishamkar Esfahani, M. Amini, A. Aminorroaya, M. Kolahdouzan, M. Nazem, Rezvan Salehidoost
Introduction: Thyroidectomy is a surgical method for the management of benign and malignant thyroid disease. Thyroidectomy may cause significant complications including hypocalcemia and recurrent laryngeal nerve injury. Permanent complications after thyroid surgery pose significant costs for healthcare system, as patients require lifelong alternative treatments and healthcare facilities. Objectives: The purpose of this study was to evaluate the incidence and risk factors for permanent complications following thyroidectomy. Patients and Methods: A total of 204 consecutive patients who underwent thyroid surgery between 2017 and 2018 were included in this prospective study. The patients were followed for 12 months after surgery and clinical and biochemical data were recorded. Results: The incidence of transient and permanent hypocalcemia was 46.8% and 6.38%, respectively. Transient hoarseness affected 30.3% of patients and 2.1% had recurrent laryngeal nerve paralysis as detected by video laryngoscopy 12 months after surgery. Surgeons volume was significantly related to the presence of permanent hypocalcemia (P=0.003). In comparison to high-volume-surgeons, intermediate-volume-surgeons had an odds ratio of 5.25 (P=0.042) for permanent complications. Conclusion: Hypocalcaemia remained the most common long-term complication of thyroid surgery. High volume surgeons had lower complication rates and better outcomes. In this regard, methods for improving surgical performance are worthy of investigation.
{"title":"Permanent complications after thyroid surgery and effect of surgeon volume","authors":"Bahareh Abrishamkar Esfahani, M. Amini, A. Aminorroaya, M. Kolahdouzan, M. Nazem, Rezvan Salehidoost","doi":"10.34172/ipp.2023.34439","DOIUrl":"https://doi.org/10.34172/ipp.2023.34439","url":null,"abstract":"Introduction: Thyroidectomy is a surgical method for the management of benign and malignant thyroid disease. Thyroidectomy may cause significant complications including hypocalcemia and recurrent laryngeal nerve injury. Permanent complications after thyroid surgery pose significant costs for healthcare system, as patients require lifelong alternative treatments and healthcare facilities. Objectives: The purpose of this study was to evaluate the incidence and risk factors for permanent complications following thyroidectomy. Patients and Methods: A total of 204 consecutive patients who underwent thyroid surgery between 2017 and 2018 were included in this prospective study. The patients were followed for 12 months after surgery and clinical and biochemical data were recorded. Results: The incidence of transient and permanent hypocalcemia was 46.8% and 6.38%, respectively. Transient hoarseness affected 30.3% of patients and 2.1% had recurrent laryngeal nerve paralysis as detected by video laryngoscopy 12 months after surgery. Surgeons volume was significantly related to the presence of permanent hypocalcemia (P=0.003). In comparison to high-volume-surgeons, intermediate-volume-surgeons had an odds ratio of 5.25 (P=0.042) for permanent complications. Conclusion: Hypocalcaemia remained the most common long-term complication of thyroid surgery. High volume surgeons had lower complication rates and better outcomes. In this regard, methods for improving surgical performance are worthy of investigation.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44034617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammadreza Khosravifarsani, R. Tolouian, Sepideh Yadollahifarsani, Parisa Soleimani, Marni Sarazen, Pouria Mostafizi, Audrey Tolouian, A. Philip, Zahra Golestani Hotkani
Lung cancer is an uncontrolled cell growth in lung tissue, with changes in the cellular, epigenetic and genetic alterations, oncogenes activation and clonal evolution of malignant cells. The most critical risk factor for lung cancer is cigarette smoking (80-85%). Other reasons for lung cancer (15-20%) include genetic factors, exposure to secondhand smoke, air pollution, radiation, hazardous gases and foreign chemical agents. The most widely used strategies in lung cancer treatment are chemotherapy, radiotherapy and surgery. However, there are various adverse effects, such as significant toxicity, limited efficiency and multidrug resistance. Plants and plant-derived products have proven to have a role in lung cancer therapy and prevention through sensitizing conventional factors, extending patient survival time, avoiding adverse effects of chemotherapy, promoting physiological improvement and ameliorating quality of life in pulmonary malignancy cases. For this review article, we searched Web of Science, EBSCO, Scopus, PubMed/Medline, DOAJ (Directory of Open Access Journals), Embase, and Google Scholar, using various keywords. There are several natural product molecules with anticancer properties through many molecular mechanisms, including, inducing apoptosis, inhibition of angiogenesis and metastasis, reversion of multidrug resistance and also targeting reactive oxygen species signaling. Some phytochemical compounds are discussed as anticancer agents for lung cancer.
癌症是肺组织中不受控制的细胞生长，伴随着细胞、表观遗传和遗传改变、癌基因激活和恶性细胞克隆进化的变化。癌症最关键的危险因素是吸烟（80-85%）。癌症的其他原因（15-20%）包括遗传因素、接触二手烟、空气污染、辐射、有害气体和外国化学制剂。癌症治疗中最广泛使用的策略是化疗、放疗和手术。然而，也存在各种不良反应，如显著的毒性、有限的效率和多药耐药性。植物和植物衍生产品已被证明在癌症的治疗和预防中发挥作用，通过提高传统因素的敏感性、延长患者的生存时间、避免化疗的不良影响、促进生理改善和改善肺部恶性肿瘤患者的生活质量。对于这篇综述文章，我们使用各种关键词搜索了Web of Science、EBSCO、Scopus、PubMed/Medline、DOAJ（开放获取期刊目录）、Embase和Google Scholar。有几种天然产物分子通过多种分子机制具有抗癌特性，包括诱导细胞凋亡、抑制血管生成和转移、逆转多药耐药性以及靶向活性氧信号传导。一些植物化学化合物被认为是癌症的抗癌剂。
{"title":"Medical plants for lung cancer: an overview of current knowledge","authors":"Mohammadreza Khosravifarsani, R. Tolouian, Sepideh Yadollahifarsani, Parisa Soleimani, Marni Sarazen, Pouria Mostafizi, Audrey Tolouian, A. Philip, Zahra Golestani Hotkani","doi":"10.34172/ipp.2022.38455","DOIUrl":"https://doi.org/10.34172/ipp.2022.38455","url":null,"abstract":"Lung cancer is an uncontrolled cell growth in lung tissue, with changes in the cellular, epigenetic and genetic alterations, oncogenes activation and clonal evolution of malignant cells. The most critical risk factor for lung cancer is cigarette smoking (80-85%). Other reasons for lung cancer (15-20%) include genetic factors, exposure to secondhand smoke, air pollution, radiation, hazardous gases and foreign chemical agents. The most widely used strategies in lung cancer treatment are chemotherapy, radiotherapy and surgery. However, there are various adverse effects, such as significant toxicity, limited efficiency and multidrug resistance. Plants and plant-derived products have proven to have a role in lung cancer therapy and prevention through sensitizing conventional factors, extending patient survival time, avoiding adverse effects of chemotherapy, promoting physiological improvement and ameliorating quality of life in pulmonary malignancy cases. For this review article, we searched Web of Science, EBSCO, Scopus, PubMed/Medline, DOAJ (Directory of Open Access Journals), Embase, and Google Scholar, using various keywords. There are several natural product molecules with anticancer properties through many molecular mechanisms, including, inducing apoptosis, inhibition of angiogenesis and metastasis, reversion of multidrug resistance and also targeting reactive oxygen species signaling. Some phytochemical compounds are discussed as anticancer agents for lung cancer.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42287868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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