Rahim Asghari, A. Abbasi, Hengameh Mojdeganlou, Yasin Farrokhi, Leila Mahmoodzadeh
Burkitt lymphoma is a very aggressive B cell lymphoma, which can rarely involve breast tissue. Although it usually affects children, but primary breast lymphomas usually, occur in older age. In this report, we present a rare case of Burkitt lymphoma in a 40-year-old woman primarily presented by bilateral breast enlargement which shortly followed by gastrointestinal and bone marrow involvement.
{"title":"Primary Burkitt lymphoma of breast presented by bilateral breast enlargement","authors":"Rahim Asghari, A. Abbasi, Hengameh Mojdeganlou, Yasin Farrokhi, Leila Mahmoodzadeh","doi":"10.34172/ipp.2022.29283","DOIUrl":"https://doi.org/10.34172/ipp.2022.29283","url":null,"abstract":"Burkitt lymphoma is a very aggressive B cell lymphoma, which can rarely involve breast tissue. Although it usually affects children, but primary breast lymphomas usually, occur in older age. In this report, we present a rare case of Burkitt lymphoma in a 40-year-old woman primarily presented by bilateral breast enlargement which shortly followed by gastrointestinal and bone marrow involvement.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44503841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sona Rafieyan, M. Sadighi Shamami, Vian Shateri, M. Ghojazadeh, F. Salehnia
Introduction: Smoking is a major health hazard. Cigarette smoke is produced by burning of complex organic compounds that include highly toxic components. Passive smokers are non-smoker individuals that are exposed to second-hand smoke (SHS) or environmental tobacco smoke (ETS). Passive or involuntary smoking is currently a major public health dilemma worldwide. Considering the increasing number of passive smokers in today’s world, it is imperative to assess the potential adverse effects of passive smoking on oral health and periodontal tissue. Objectives: This study aimed to assess the correlation between exposure to ETS and periodontitis in passive smokers. Methods: In this systematic review, the Google Scholar, PubMed and Scopus databases were searched for relevant articles published from 1990 to 2020. The extracted data were tabulated. Results: Search of the literature yielded 77 articles based on the searched keywords. After assessing the abstracts and excluding the duplicates, 68 articles remained. After accurate assessment by the examiners, 21 articles were selected for the full-text review. Finally, seven eligible articles remained in the study for the final review. Conclusion: Cigarette smoke affects the immune system and aggravates periodontal destruction as such. Despite the available evidence regarding the correlation of periodontal parameters and exposure to ETS in passive smokers, more comprehensive studies on this topic are still required to achieve a definite therapeutic protocol considering the small number of available studies on this topic, methodological flaws and the existing controversies.
{"title":"Correlation of exposure to environmental tobacco smoke and periodontitis in passive smokers; a systematic review","authors":"Sona Rafieyan, M. Sadighi Shamami, Vian Shateri, M. Ghojazadeh, F. Salehnia","doi":"10.34172/ipp.2022.29308","DOIUrl":"https://doi.org/10.34172/ipp.2022.29308","url":null,"abstract":"Introduction: Smoking is a major health hazard. Cigarette smoke is produced by burning of complex organic compounds that include highly toxic components. Passive smokers are non-smoker individuals that are exposed to second-hand smoke (SHS) or environmental tobacco smoke (ETS). Passive or involuntary smoking is currently a major public health dilemma worldwide. Considering the increasing number of passive smokers in today’s world, it is imperative to assess the potential adverse effects of passive smoking on oral health and periodontal tissue. Objectives: This study aimed to assess the correlation between exposure to ETS and periodontitis in passive smokers. Methods: In this systematic review, the Google Scholar, PubMed and Scopus databases were searched for relevant articles published from 1990 to 2020. The extracted data were tabulated. Results: Search of the literature yielded 77 articles based on the searched keywords. After assessing the abstracts and excluding the duplicates, 68 articles remained. After accurate assessment by the examiners, 21 articles were selected for the full-text review. Finally, seven eligible articles remained in the study for the final review. Conclusion: Cigarette smoke affects the immune system and aggravates periodontal destruction as such. Despite the available evidence regarding the correlation of periodontal parameters and exposure to ETS in passive smokers, more comprehensive studies on this topic are still required to achieve a definite therapeutic protocol considering the small number of available studies on this topic, methodological flaws and the existing controversies.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41845175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is increasing interest in biologicals in steroid-resistant or steroid-dependent eosinophilic granulomatosis with polyangiitis (EGPA). We describe successful benralizumab monotherapy in asthma-dominant EGPA. Sixteen years ago, a 38-year-old male was diagnosed with multisystemic illness with asthma, arthralgias, Bell’s palsy and nephrotic syndrome, with 20.3% eosinophilia (absolute count 1160 K/µL), ESR 50 mm/hour, albumin 2.3 g/dL, serum creatinine 1.1 mg/dL, slightly above baseline and negative immunology work. Kidney biopsy demonstrated diffuse podocyte foot process effacement with minimal change disease, without vasculitis and EGPA was diagnosed. He achieved early remission with corticosteroids and intravenous cyclophosphamide and was maintained on prednisone and mycophenolate mofetil. Nevertheless, he repeatedly experienced severe asthma exacerbations, falls in FEV-1% and recurrent relapsing eosinophilia. He was successfully started on benralizumab and was weaned off mycophenolate mofetil and prednisone. Eosinophilia was corrected and FEV-1% normalized. We support calls for larger trials of the biologicals in EGPA.
{"title":"Benralizumab substitution monotherapy in symptomatic relapsing asthma-dominant eosinophilic granulomatosis with polyangiitis","authors":"M. Onuigbo, B. Libman, M. Lazarovich","doi":"10.34172/ipp.2022.31373","DOIUrl":"https://doi.org/10.34172/ipp.2022.31373","url":null,"abstract":"There is increasing interest in biologicals in steroid-resistant or steroid-dependent eosinophilic granulomatosis with polyangiitis (EGPA). We describe successful benralizumab monotherapy in asthma-dominant EGPA. Sixteen years ago, a 38-year-old male was diagnosed with multisystemic illness with asthma, arthralgias, Bell’s palsy and nephrotic syndrome, with 20.3% eosinophilia (absolute count 1160 K/µL), ESR 50 mm/hour, albumin 2.3 g/dL, serum creatinine 1.1 mg/dL, slightly above baseline and negative immunology work. Kidney biopsy demonstrated diffuse podocyte foot process effacement with minimal change disease, without vasculitis and EGPA was diagnosed. He achieved early remission with corticosteroids and intravenous cyclophosphamide and was maintained on prednisone and mycophenolate mofetil. Nevertheless, he repeatedly experienced severe asthma exacerbations, falls in FEV-1% and recurrent relapsing eosinophilia. He was successfully started on benralizumab and was weaned off mycophenolate mofetil and prednisone. Eosinophilia was corrected and FEV-1% normalized. We support calls for larger trials of the biologicals in EGPA.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42938208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Barahman, Elham Emami, M. Biglari Abhari, E. Ahmadian, M. Mubarak, M. Bahadoram, A. Maghsoudi, A. Baradaran, Niloufar Hooshyar
Introduction: IgA nephropathy (IgAN) regarded as the main type of primary glomerulonephritis globally. It has a diverse clinical course and unpredictable prognosis. Traditionally, clinical and pathological features are conducted to prognosticate the outcome of the disease. Recently, attention has been directed towards other indices that may have prognostic implications for IgAN progression. The Ki-67 index have been extensively detected as a proliferation marker of malignant cells for several years. Objectives: In this study, we aimed to determine the prognostic impact of Ki-67 expression in IgAN biopsies. Patients and Methods: This cross-sectional study was conducted on 18 biopsy-proven IgAN patients. IgAN was diagnosed by significant IgA deposits and according to the morphologic variables of Oxford (MEST) classification for this disease. The expression of Ki-67 in the glomeruli, interstitium and tubules was described as the intensity percentage of the immunohistochemical staining. Results: In all of the eighteen cases with biopsy-proven IgAN, the mean ± SD of age, degree of proteinuria and serum creatinine were 36.3±17 years, 1600±733 mg/day and 1.2±0.4 mg/dL, respectively. In this study, we found a significant correlation between glomerular Ki-67 immunohistochemical staining and MEST scores (r: 0.780, P< 0.001). We also detected a significant correlation between interstitial Ki-67 staining and MEST scores (r: 0.700, P=0.001). Moreover, Ki-67 immunohistochemical staining of the interstitium had a significant relationship with IgM deposits (r=0.544, P=0.02). Conclusion: In this pilot study, we found that interstitial and glomerular Ki-67 immunohistochemical staining had positive and significant associations with MEST scores. Our data also showed that interstitial Ki-67 staining had a significant relationship with IgM deposits. These preliminary results require further investigation in large-scale studies.
{"title":"Ki-67 proliferative index in immunoglobulin A nephropathy; A pilot study","authors":"M. Barahman, Elham Emami, M. Biglari Abhari, E. Ahmadian, M. Mubarak, M. Bahadoram, A. Maghsoudi, A. Baradaran, Niloufar Hooshyar","doi":"10.34172/ipp.2022.31369","DOIUrl":"https://doi.org/10.34172/ipp.2022.31369","url":null,"abstract":"Introduction: IgA nephropathy (IgAN) regarded as the main type of primary glomerulonephritis globally. It has a diverse clinical course and unpredictable prognosis. Traditionally, clinical and pathological features are conducted to prognosticate the outcome of the disease. Recently, attention has been directed towards other indices that may have prognostic implications for IgAN progression. The Ki-67 index have been extensively detected as a proliferation marker of malignant cells for several years. Objectives: In this study, we aimed to determine the prognostic impact of Ki-67 expression in IgAN biopsies. Patients and Methods: This cross-sectional study was conducted on 18 biopsy-proven IgAN patients. IgAN was diagnosed by significant IgA deposits and according to the morphologic variables of Oxford (MEST) classification for this disease. The expression of Ki-67 in the glomeruli, interstitium and tubules was described as the intensity percentage of the immunohistochemical staining. Results: In all of the eighteen cases with biopsy-proven IgAN, the mean ± SD of age, degree of proteinuria and serum creatinine were 36.3±17 years, 1600±733 mg/day and 1.2±0.4 mg/dL, respectively. In this study, we found a significant correlation between glomerular Ki-67 immunohistochemical staining and MEST scores (r: 0.780, P< 0.001). We also detected a significant correlation between interstitial Ki-67 staining and MEST scores (r: 0.700, P=0.001). Moreover, Ki-67 immunohistochemical staining of the interstitium had a significant relationship with IgM deposits (r=0.544, P=0.02). Conclusion: In this pilot study, we found that interstitial and glomerular Ki-67 immunohistochemical staining had positive and significant associations with MEST scores. Our data also showed that interstitial Ki-67 staining had a significant relationship with IgM deposits. These preliminary results require further investigation in large-scale studies.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42956143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease that associated with abnormal airflow during respiration. It has been demonstrated that supplemental oxygen used in the time of exercise testing has a considerable positive effect in cases with COPD. Objectives: Present study was aimed to investigate the possible effects of supplemental oxygen on the outcomes of 6-minute walk test (6MWT). Patients and Methods: COPD cases were randomly divided into two groups (n= 50/each). Group1; patients who received nasal oxygen during the 6MWT, and group two were patients who did not receive supplemental oxygen during the test. Results: The Shapiro-Wilk test showed that the distribution of all parameters in two groups followed the normal distribution. The total distance walked was 431.54±40.76 m in the intervention group and 399.08±49.94 m in the control group, with a significant difference between the two groups (P= 0.001). After 6MWT, the mean of SpO2 in the intervention group was significantly higher than the control group (P= 0.002) and the degree of dyspnea was significantly lower than the control group (P= 0.031). Conclusion: Overall, supplemental oxygen has significant positive effects in COPD patients, but definitive commentary is needed for further studies. Trial registration: The trial protocol was approved by the Thai Clinical Trials Registry (identifier: TCTR20220122001; https://www.thaiclinicaltrials.org, ethical code; IR.MUI.MED.REC. 1396.308.3).
{"title":"The effect of supplemental oxygen on 6-minute walk test in chronic obstructive pulmonary disease patients","authors":"Farzin Ghiasi, Fatemeh Sajjadfar, S. Sadeghi","doi":"10.34172/ipp.2022.25262","DOIUrl":"https://doi.org/10.34172/ipp.2022.25262","url":null,"abstract":"Introduction: Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease that associated with abnormal airflow during respiration. It has been demonstrated that supplemental oxygen used in the time of exercise testing has a considerable positive effect in cases with COPD. Objectives: Present study was aimed to investigate the possible effects of supplemental oxygen on the outcomes of 6-minute walk test (6MWT). Patients and Methods: COPD cases were randomly divided into two groups (n= 50/each). Group1; patients who received nasal oxygen during the 6MWT, and group two were patients who did not receive supplemental oxygen during the test. Results: The Shapiro-Wilk test showed that the distribution of all parameters in two groups followed the normal distribution. The total distance walked was 431.54±40.76 m in the intervention group and 399.08±49.94 m in the control group, with a significant difference between the two groups (P= 0.001). After 6MWT, the mean of SpO2 in the intervention group was significantly higher than the control group (P= 0.002) and the degree of dyspnea was significantly lower than the control group (P= 0.031). Conclusion: Overall, supplemental oxygen has significant positive effects in COPD patients, but definitive commentary is needed for further studies. Trial registration: The trial protocol was approved by the Thai Clinical Trials Registry (identifier: TCTR20220122001; https://www.thaiclinicaltrials.org, ethical code; IR.MUI.MED.REC. 1396.308.3).","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46774423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Rajaei, Haleh Sadraee, P. Dehghan, M. Emam, A. Ahmadzadeh, F. Farsad, Z. Abbasi
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disorder that can cause vascular involvement. The vascular changes can be seen in the bed of the nails. It was observed that SLE has a relationship with bone mineral density (BMD) changes. Objectives: This study aimed to investigate the frequency and types of capillaroscopic change in SLE and its relationship between capillaroscopic changes with BMD in SLE. Patients and Methods: Thirty-three patients with SLE who were referred to Resalat hospital (Tehran, Iran) underwent nailfold capillaroscopy (NFC). In addition, these patients were evaluated for BMD from spine and hip. Moreover, the correlation of these data was assessed. Result: Scleroderma pattern was seen in 12.12% of patients, non-scleroderma pattern (NSP) in 27.3% patients and normal pattern in 60.6% based on NFC. There was no relationship between gender and NFC. The mean age was 43.30 years and 78.8% of patients were female. Dimension and morphological abnormalities had a relationship with scleroderma pattern (P=0.033 and P=0.014 respectively). There was a relationship between spine BMD and morphological abnormality too (P=0.013). Conclusion: NFC is a good method for evaluating vascular change in patients with SLE and in this method, abnormal morphology and dimension have higher prevalence than other abnormalities in patients with SLE. Additionally, a relationship between abnormal morphology in NFC and spinal osteoporosis in SLE patients was detected.
{"title":"Correlation between capillaroscopic findings and bone mineral density results in the systemic lupus erythematosus patients","authors":"A. Rajaei, Haleh Sadraee, P. Dehghan, M. Emam, A. Ahmadzadeh, F. Farsad, Z. Abbasi","doi":"10.34172/ipp.2022.29292","DOIUrl":"https://doi.org/10.34172/ipp.2022.29292","url":null,"abstract":"Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disorder that can cause vascular involvement. The vascular changes can be seen in the bed of the nails. It was observed that SLE has a relationship with bone mineral density (BMD) changes. Objectives: This study aimed to investigate the frequency and types of capillaroscopic change in SLE and its relationship between capillaroscopic changes with BMD in SLE. Patients and Methods: Thirty-three patients with SLE who were referred to Resalat hospital (Tehran, Iran) underwent nailfold capillaroscopy (NFC). In addition, these patients were evaluated for BMD from spine and hip. Moreover, the correlation of these data was assessed. Result: Scleroderma pattern was seen in 12.12% of patients, non-scleroderma pattern (NSP) in 27.3% patients and normal pattern in 60.6% based on NFC. There was no relationship between gender and NFC. The mean age was 43.30 years and 78.8% of patients were female. Dimension and morphological abnormalities had a relationship with scleroderma pattern (P=0.033 and P=0.014 respectively). There was a relationship between spine BMD and morphological abnormality too (P=0.013). Conclusion: NFC is a good method for evaluating vascular change in patients with SLE and in this method, abnormal morphology and dimension have higher prevalence than other abnormalities in patients with SLE. Additionally, a relationship between abnormal morphology in NFC and spinal osteoporosis in SLE patients was detected.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49101415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ahmadi, H. Javaherizadeh, S. Dehghani, Parisa Amoori, Marjaneh Khalighi
{"title":"An infant with significant elevation of alanine aminotransferase and elevated serum creatinine: autoimmune hepatitis or not?","authors":"M. Ahmadi, H. Javaherizadeh, S. Dehghani, Parisa Amoori, Marjaneh Khalighi","doi":"10.34172/ipp.2022.31340","DOIUrl":"https://doi.org/10.34172/ipp.2022.31340","url":null,"abstract":"<jats:p>\u0000 </jats:p>","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44851936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amid Yazdani, Farshad Namdari, S. Gorgani-Firuzjaee, Hassan Niroomand
Introduction: Prostate cancer is among the most common malignancies in men which can be well-managed if early diagnosed. Nevertheless, to date, no accurate index has been detected in order to differentiate prostate cancer from the other benign conditions practically except biopsies that is an invasive procedure. Objectives: The current study is aimed to assess the values of urinary prostate cancer antigen 3 (PCA3) in prostate cancer diagnosis. Patients and Methods: This case-control study was conducted on 28 patients with elevated levels of prostate-specific antigen (PSA) who underwent transrectal prostate biopsies in 2019. The urinary level of PCA 3 was measured using real-time polymerase chain reaction (RT-PCR). Ultrasonography was performed to assess the volume of prostate, as well. PSA density (PSAD) was defined as PSA divided by prostate volume. The patients were divided into two groups of benign prostatic hyperplasia (BPH) or prostate cancer based on prostate biopsy pathological report. The values of PCA 3 were evaluated. Results: PCA 3 had accuracy of 0.708 at cut-off point of 27.75 with measured AUC of 0.720 (95% CI: 0.510- 0.931), sensitivity and specificity of 72% and 69%, respectively. PSA had accuracy, sensitivity, and specificity of 0.708, 70% and 71.4% at cut-off of 9, whereas PSAD had 0.667, 88% and 50% at cut-off of 4.8, respectively. Conclusion: Based on the findings of this study, urinary PCA 3 can be considered as a valuable biomarker for the prediction of malignancy in prostate biopsies with the sensitivity and specificity of 72.7% and 69.2% at the cut-off level of 27.75, respectively.
{"title":"Evaluation of the urine mRNA-PCA3 expression level in prostate patients; comparison between benign prostatic hyperplasia and cancer","authors":"Amid Yazdani, Farshad Namdari, S. Gorgani-Firuzjaee, Hassan Niroomand","doi":"10.34172/ipp.2022.15207","DOIUrl":"https://doi.org/10.34172/ipp.2022.15207","url":null,"abstract":"Introduction: Prostate cancer is among the most common malignancies in men which can be well-managed if early diagnosed. Nevertheless, to date, no accurate index has been detected in order to differentiate prostate cancer from the other benign conditions practically except biopsies that is an invasive procedure. Objectives: The current study is aimed to assess the values of urinary prostate cancer antigen 3 (PCA3) in prostate cancer diagnosis. Patients and Methods: This case-control study was conducted on 28 patients with elevated levels of prostate-specific antigen (PSA) who underwent transrectal prostate biopsies in 2019. The urinary level of PCA 3 was measured using real-time polymerase chain reaction (RT-PCR). Ultrasonography was performed to assess the volume of prostate, as well. PSA density (PSAD) was defined as PSA divided by prostate volume. The patients were divided into two groups of benign prostatic hyperplasia (BPH) or prostate cancer based on prostate biopsy pathological report. The values of PCA 3 were evaluated. Results: PCA 3 had accuracy of 0.708 at cut-off point of 27.75 with measured AUC of 0.720 (95% CI: 0.510- 0.931), sensitivity and specificity of 72% and 69%, respectively. PSA had accuracy, sensitivity, and specificity of 0.708, 70% and 71.4% at cut-off of 9, whereas PSAD had 0.667, 88% and 50% at cut-off of 4.8, respectively. Conclusion: Based on the findings of this study, urinary PCA 3 can be considered as a valuable biomarker for the prediction of malignancy in prostate biopsies with the sensitivity and specificity of 72.7% and 69.2% at the cut-off level of 27.75, respectively.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48336756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hoda Sayed Elkhodary, Khaled E Nasr, S. Ahmed, M. Shakweer, Mai MA Ezz-Eldin
Introduction: The expression of programmed cell death-ligand 1 (PD-L1) and its correlation with the prognosis of renal cell carcinoma (RCC) remains controversial. Objectives: This study aimed to study PD-L1 expression in tumor cells and tumor-infiltrating lymphocytes (TILs) in patients with RCC and its association with clinicopathological factors and survival outcomes. Patients and Methods: PD-L1 expression in tumor cells and TILs was analyzed using immunohistochemistry (IHC) from patients with histologically proven RCC. Results: PD-L1 was positive in tumor cells for 55.8% of patients. PDL-1 expression in TIL was reported in 31.2 % of patients. Patients with PDL1 positive tumor cells had higher median tumor size (P=0.07), higher nuclear grade (P=0.56), and higher lymphovascular invasion (LVI) (P=0.23). Patients with PDL1 positive TILs were significantly associated with larger median pathological tumor size (P=0.02), higher probability of renal fat invasion (P=0.001), higher nuclear grade (P=0.05), higher probability of positive margin (P=0.02), positive LVI (P=0.03), higher pathological T stage (P=0.0004); whereas patients with PDL-1 negative TILs had earlier stage at presentation (stage I-II) (P=0.004). There was no statistically significant difference in disease-free survival (DFS), progression-free survival (PFS), or overall survival (OS) for PD-L1 expression of tumor cells and TILs. Conclusion: PDL1 positivity in TILs and not in tumor cells was significantly associated with more aggressive features, and higher stage. No association was found with DFS, PFS, or OS. These data suggest that PD-L1 expression of TILs in RCC tumors contributes to cancer aggressiveness.
{"title":"Clinicopathological correlation and prognostic value of PD-L1 expression in renal cell carcinoma","authors":"Hoda Sayed Elkhodary, Khaled E Nasr, S. Ahmed, M. Shakweer, Mai MA Ezz-Eldin","doi":"10.34172/ipp.2022.30329","DOIUrl":"https://doi.org/10.34172/ipp.2022.30329","url":null,"abstract":"Introduction: The expression of programmed cell death-ligand 1 (PD-L1) and its correlation with the prognosis of renal cell carcinoma (RCC) remains controversial. Objectives: This study aimed to study PD-L1 expression in tumor cells and tumor-infiltrating lymphocytes (TILs) in patients with RCC and its association with clinicopathological factors and survival outcomes. Patients and Methods: PD-L1 expression in tumor cells and TILs was analyzed using immunohistochemistry (IHC) from patients with histologically proven RCC. Results: PD-L1 was positive in tumor cells for 55.8% of patients. PDL-1 expression in TIL was reported in 31.2 % of patients. Patients with PDL1 positive tumor cells had higher median tumor size (P=0.07), higher nuclear grade (P=0.56), and higher lymphovascular invasion (LVI) (P=0.23). Patients with PDL1 positive TILs were significantly associated with larger median pathological tumor size (P=0.02), higher probability of renal fat invasion (P=0.001), higher nuclear grade (P=0.05), higher probability of positive margin (P=0.02), positive LVI (P=0.03), higher pathological T stage (P=0.0004); whereas patients with PDL-1 negative TILs had earlier stage at presentation (stage I-II) (P=0.004). There was no statistically significant difference in disease-free survival (DFS), progression-free survival (PFS), or overall survival (OS) for PD-L1 expression of tumor cells and TILs. Conclusion: PDL1 positivity in TILs and not in tumor cells was significantly associated with more aggressive features, and higher stage. No association was found with DFS, PFS, or OS. These data suggest that PD-L1 expression of TILs in RCC tumors contributes to cancer aggressiveness.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48052562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Mowla, Elham Emami, M. Biglari Abhari, S. Zununi Vahed, M. Mubarak, M. Bahadoram, A. Maghsoudi, H. Nasri, Niloufar Hooshyar
Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that involves multiple organs including the kidneys, skin, joints and serous membranes. Previous studies have shown that elevated Ki-67 indices are correlated with the cellular proliferation and clinical findings in lupus nephritis (LN). Objectives: The aim of this study was to examine the relationship between glomerular, tubular and interstitial expression of Ki-67 in kidney biopsy specimens of different classes of LN and and various clinicopathological features. Patients and Methods: This cross-sectional study was conducted on 16 biopsy-proven LN patients. The diagnosis of LN was based on renal biopsy findings, particularly by immunofluorescence (IF) study. The diagnosis of LN with IF was concluded by the deposition of C1q in association with prominent IgG and C3 deposits and the deposition of IgM and IgA (full-house pattern). The morphologic variables on light microscopy were also examined. In this study, the glomerular (gKi-67), interstitial (iKi-67) and tubular (tKi-67) expressions of Ki-67 were assessed. Results: This study comprised of 16 cases of biopsy-proven LN which were stained for Ki-67 with immunohistochemistry. Of the 16 patients, 13 (81.2%) were females. The mean ± SD of age, quantity of proteinuria and serum creatinine in all patients were 37±11.6 years, 1844±582 mg/d and 1.5±0.93 mg/ dL, respectively. Our study showed that the association between gKi-67, iKi-67, and tKi-67 with age, gender, level of proteinuria and serum creatinine was not significant (P>0.05). The association between Ki-67 with interstitial fibrosis, the number of crescents, and the activity and chronicity percentages was also not significant (P>0.05). Moreover, the relationship of gKi-67 with global versus segmental involvement of the glomeruli was not significant (P>0.05). Furthermore, the correlation of gKi-67 with IgA, IgG, IgM, C3 and C1q deposits was not significant (P>0.05). The association of iKi-67 with age, gender, level of proteinuria and serum creatinine was not significant as well. However, the correlation of iKi-67 with C1q deposits was inversely significant (r=-0.544, P=0.029); however this correlation was not significant with IgA, IgG, IgM and C3 deposits (P>0.05). Conclusion: In this study, the relationship of iKi-67 with C1q deposits suggests that C1q has a significant role in the inflammatory process of LN. Since our study was conducted on a relatively small sample size, it, therefore, requires further investigations on larger samples.
{"title":"Ki-67 proliferative index in kidney biopsies of lupus nephritis patients: a preliminary study","authors":"K. Mowla, Elham Emami, M. Biglari Abhari, S. Zununi Vahed, M. Mubarak, M. Bahadoram, A. Maghsoudi, H. Nasri, Niloufar Hooshyar","doi":"10.34172/ipp.2022.31370","DOIUrl":"https://doi.org/10.34172/ipp.2022.31370","url":null,"abstract":"Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that involves multiple organs including the kidneys, skin, joints and serous membranes. Previous studies have shown that elevated Ki-67 indices are correlated with the cellular proliferation and clinical findings in lupus nephritis (LN). Objectives: The aim of this study was to examine the relationship between glomerular, tubular and interstitial expression of Ki-67 in kidney biopsy specimens of different classes of LN and and various clinicopathological features. Patients and Methods: This cross-sectional study was conducted on 16 biopsy-proven LN patients. The diagnosis of LN was based on renal biopsy findings, particularly by immunofluorescence (IF) study. The diagnosis of LN with IF was concluded by the deposition of C1q in association with prominent IgG and C3 deposits and the deposition of IgM and IgA (full-house pattern). The morphologic variables on light microscopy were also examined. In this study, the glomerular (gKi-67), interstitial (iKi-67) and tubular (tKi-67) expressions of Ki-67 were assessed. Results: This study comprised of 16 cases of biopsy-proven LN which were stained for Ki-67 with immunohistochemistry. Of the 16 patients, 13 (81.2%) were females. The mean ± SD of age, quantity of proteinuria and serum creatinine in all patients were 37±11.6 years, 1844±582 mg/d and 1.5±0.93 mg/ dL, respectively. Our study showed that the association between gKi-67, iKi-67, and tKi-67 with age, gender, level of proteinuria and serum creatinine was not significant (P>0.05). The association between Ki-67 with interstitial fibrosis, the number of crescents, and the activity and chronicity percentages was also not significant (P>0.05). Moreover, the relationship of gKi-67 with global versus segmental involvement of the glomeruli was not significant (P>0.05). Furthermore, the correlation of gKi-67 with IgA, IgG, IgM, C3 and C1q deposits was not significant (P>0.05). The association of iKi-67 with age, gender, level of proteinuria and serum creatinine was not significant as well. However, the correlation of iKi-67 with C1q deposits was inversely significant (r=-0.544, P=0.029); however this correlation was not significant with IgA, IgG, IgM and C3 deposits (P>0.05). Conclusion: In this study, the relationship of iKi-67 with C1q deposits suggests that C1q has a significant role in the inflammatory process of LN. Since our study was conducted on a relatively small sample size, it, therefore, requires further investigations on larger samples.","PeriodicalId":13454,"journal":{"name":"Immunopathologia Persa","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46228612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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