Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2148
Reshma Mohamed Ansari, Hong Wei Han, Sarah Idris, Atikah Abdul Latiff
INTRODUCTION: As a part of the MBBS curriculum review exercise, University of Cyberjaya (UoC), Malaysia had come up with a study to investigate the feedback and learning needs pertaining to radiological anatomy (RA) in pre-clinical teaching. MATERIALS AND METHODS: A single-institutional survey of all five-year medical students was done using an adapted instrument which had both open and close-ended questions on the radiological anatomy teaching received so far and the perception on the teaching methods and content. 405 respondents out of 503 (80%) (year 1=115, year 2= 78, year 3=79, year 4=78, year 5=55) replied. There were totally 136 male and 269 female respondents. RESULTS: Though the overall student learning time (SLT) was adequate, year 3 students (62%) reported inadequate radiological anatomy SLT. Pre[1]clinical students (57.5%) reported more of formal radiological anatomy teaching while clinical students indicated informal teaching (Informal: 15.1 %, Even mix of formal and informal: 56.6 %). Female students reported higher response of adequate SLT (69.1%) and formal teaching (46.9%) compared to males. Small group learning such as gross anatomy practical sessions, problem-based learning, clinical skills teaching, and clinical correlates sessions were recommended. Abdomen and thorax were the most preferred regions where radiological anatomy could be explored further. X-ray followed by CT and MRI were the most favoured radiological modalities to learn topographical anatomy. CONCLUSION: The study provided sound feedback on the existing radiological anatomy teaching practices. Data shows stark contrast between the needs of the students and the current practices indicating that it is quite substantial for curriculum review.
{"title":"Contextual, Radiological Anatomy (RA) Learning needs Evaluation for Curricular Improvement","authors":"Reshma Mohamed Ansari, Hong Wei Han, Sarah Idris, Atikah Abdul Latiff","doi":"10.31436/imjm.v22i2.2148","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2148","url":null,"abstract":"INTRODUCTION: As a part of the MBBS curriculum review exercise, University of Cyberjaya (UoC), Malaysia had come up with a study to investigate the feedback and learning needs pertaining to radiological anatomy (RA) in pre-clinical teaching. MATERIALS AND METHODS: A single-institutional survey of all five-year medical students was done using an adapted instrument which had both open and close-ended questions on the radiological anatomy teaching received so far and the perception on the teaching methods and content. 405 respondents out of 503 (80%) (year 1=115, year 2= 78, year 3=79, year 4=78, year 5=55) replied. There were totally 136 male and 269 female respondents. RESULTS: Though the overall student learning time (SLT) was adequate, year 3 students (62%) reported inadequate radiological anatomy SLT. Pre[1]clinical students (57.5%) reported more of formal radiological anatomy teaching while clinical students indicated informal teaching (Informal: 15.1 %, Even mix of formal and informal: 56.6 %). Female students reported higher response of adequate SLT (69.1%) and formal teaching (46.9%) compared to males. Small group learning such as gross anatomy practical sessions, problem-based learning, clinical skills teaching, and clinical correlates sessions were recommended. Abdomen and thorax were the most preferred regions where radiological anatomy could be explored further. X-ray followed by CT and MRI were the most favoured radiological modalities to learn topographical anatomy. CONCLUSION: The study provided sound feedback on the existing radiological anatomy teaching practices. Data shows stark contrast between the needs of the students and the current practices indicating that it is quite substantial for curriculum review.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84809031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2204
Darwin, Sulmiati, Ahmadwirawan, A. A. Zainuddin, Fonny Josh, S. Laidding, Nita Mariana, M. Faruk
INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt the anal sphincter and cause considerable morbidity. Non-invasive anal trauma therapies have been widely developed, including growth factors administered as platelet-rich plasma (PRP) and stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) and limited growth factor. This study aimed to assess PRP and SVF effects on capillary histopathology in the anal trauma Wistar rat model. MATERIALS AND METHODS: This experimental study used a rat model. Rats were divided into three groups: Group A (n=12) was treated with PRP and SVFs; Group B (n=12) was treated with normal saline (placebo); Group C (n=4) was sacrificed on day 0 to obtain baseline capillary counts. Groups A and B were further divided into three subgroups, sacrificed on days 1, 7, and 14 post-treatment. RESULTS: Capillary counts significantly showed higher density between Groups A and B (p=0.037, analysis of variance). On day 7, there was a significant difference between Groups A and B (p=0.001). CONCLUSION: Mean capillary density significantly improved in anal trauma treated with a combination of PRP and SVFs compared to control. Our findings support the use of PRP and SVFs to aid recovery of patients with anal trauma.
{"title":"Effects of Stromal Vascular Fraction and Platelet-Rich Plasma Treatment on Capillary Histopathology During Anal Trauma Healing in Rats: An in Vivo Study","authors":"Darwin, Sulmiati, Ahmadwirawan, A. A. Zainuddin, Fonny Josh, S. Laidding, Nita Mariana, M. Faruk","doi":"10.31436/imjm.v22i2.2204","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2204","url":null,"abstract":"INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt the anal sphincter and cause considerable morbidity. Non-invasive anal trauma therapies have been widely developed, including growth factors administered as platelet-rich plasma (PRP) and stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) and limited growth factor. This study aimed to assess PRP and SVF effects on capillary histopathology in the anal trauma Wistar rat model. MATERIALS AND METHODS: This experimental study used a rat model. Rats were divided into three groups: Group A (n=12) was treated with PRP and SVFs; Group B (n=12) was treated with normal saline (placebo); Group C (n=4) was sacrificed on day 0 to obtain baseline capillary counts. Groups A and B were further divided into three subgroups, sacrificed on days 1, 7, and 14 post-treatment. RESULTS: Capillary counts significantly showed higher density between Groups A and B (p=0.037, analysis of variance). On day 7, there was a significant difference between Groups A and B (p=0.001). CONCLUSION: Mean capillary density significantly improved in anal trauma treated with a combination of PRP and SVFs compared to control. Our findings support the use of PRP and SVFs to aid recovery of patients with anal trauma.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83873666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2057
Gurpreet Kaur Autar Singh, M. Midin, Hajar Mohd Salleh Sahimi, Shalisah Sarip
Managing people with borderline personality disorder (BPD) is an arduous task due to the complexity of the condition. This paper describes the role of Cognitive Behaviour Therapy (CBT) in a patient diagnosed with BPD who has undergone a modified DBT skill group training. Despite receiving multiple interventions in the past, this patient had her bouts of struggles living with this illness which required a new approach to facilitate her recovery. A trial of a short-term, 12 session-ed treatment of mindfulness-based CBT was commenced. In this case report we describe the challenges and modifications which surpass during this session and literature review on the role of CBT on BPD.
{"title":"Is Cognitive Behaviour Therapy Effective for Borderline Personality Disorder : A Case Report and Review of Literature","authors":"Gurpreet Kaur Autar Singh, M. Midin, Hajar Mohd Salleh Sahimi, Shalisah Sarip","doi":"10.31436/imjm.v22i2.2057","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2057","url":null,"abstract":"Managing people with borderline personality disorder (BPD) is an arduous task due to the complexity of the condition. This paper describes the role of Cognitive Behaviour Therapy (CBT) in a patient diagnosed with BPD who has undergone a modified DBT skill group training. Despite receiving multiple interventions in the past, this patient had her bouts of struggles living with this illness which required a new approach to facilitate her recovery. A trial of a short-term, 12 session-ed treatment of mindfulness-based CBT was commenced. In this case report we describe the challenges and modifications which surpass during this session and literature review on the role of CBT on BPD.\u0000 ","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73898157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.1939
Nurul Syazana Mohamad Shah, W. R. W. Wan Makhtar, Saliza Ainuddin Yeap, W. W. Wan Sulaiman, Ahmad Burhanuddin Abdullah
INTRODUCTION: Acceptable maxillary growth in bilateral cleft lip and palate (BCLP) is difficult to achieve. Pre-surgical orthopedic treatment aims at the reduction of cleft size by guiding growth and functional rehabilitation. The objective of this study was to evaluate the impact of Pre-surgical Orthopedics Appliances (PSOAs) on facial growth in BCLP. MATERIALS AND METHODS: Consented subjects were patients who were treated in Hospital Universiti Sains, Malaysia, and Hospital Raja Perempuan Zainab II. Ages of patients ranged from 7 to 21 years of age with non-syndromic cleft and no associated anomalies. A lateral cephalogram was taken and data collected was analyzed to compare the facial growth of BCLP with and without PSOA and between active and passive PSOA. RESULTS: The study sample comprised of 52 BCLP patients with 26 having PSOA and 26 did not having PSOA. Among these patients, those who had PSOA had significant shorter length of PNS-ANS (3.69 mm; p= 0.04) and Co-A (8.38 mm; p=0.04) compared to those who did not have PSOA. However, there were no significant difference in the length measurements between passive and active PSOA users. CONCLUSION: The usage of PSOA gives a shorter maxillary length in the facial growth of bilateral cleft patients. This study proved the effectiveness of PSOA on facial growth of cleft patients in local population.
简介:双侧唇腭裂(BCLP)的上颌生长是难以实现的。术前矫形治疗的目的是通过指导生长和功能康复来减小腭裂的大小。本研究的目的是评估术前矫形器(PSOAs)对BCLP患者面部生长的影响。材料和方法:同意的受试者是在马来西亚Universiti Sains医院和Raja Perempuan Zainab II医院接受治疗的患者。患者年龄从7岁到21岁不等，无综合征性唇裂，无相关异常。采用侧位脑电图，并对收集的数据进行分析，比较BCLP在有PSOA和没有PSOA以及主动和被动PSOA之间的面部生长。结果:研究样本包括52例BCLP患者，其中26例有PSOA, 26例无PSOA。在这些患者中，PSOA患者的PNS-ANS长度明显缩短(3.69 mm;p= 0.04)和Co-A (8.38 mm;p=0.04)。然而，被动和主动PSOA用户之间的长度测量没有显著差异。结论:应用PSOA可缩短双侧唇裂患者的上颌长度。本研究证实了PSOA对当地人群唇腭裂患者面部生长的有效性。
{"title":"The Impact of Pre-surgical Orthopedics Appliances (PSOAs) in Bilateral Cleft Lip and Palate (BCLP) Patients","authors":"Nurul Syazana Mohamad Shah, W. R. W. Wan Makhtar, Saliza Ainuddin Yeap, W. W. Wan Sulaiman, Ahmad Burhanuddin Abdullah","doi":"10.31436/imjm.v22i2.1939","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.1939","url":null,"abstract":"INTRODUCTION: Acceptable maxillary growth in bilateral cleft lip and palate (BCLP) is difficult to achieve. Pre-surgical orthopedic treatment aims at the reduction of cleft size by guiding growth and functional rehabilitation. The objective of this study was to evaluate the impact of Pre-surgical Orthopedics Appliances (PSOAs) on facial growth in BCLP. MATERIALS AND METHODS: Consented subjects were patients who were treated in Hospital Universiti Sains, Malaysia, and Hospital Raja Perempuan Zainab II. Ages of patients ranged from 7 to 21 years of age with non-syndromic cleft and no associated anomalies. A lateral cephalogram was taken and data collected was analyzed to compare the facial growth of BCLP with and without PSOA and between active and passive PSOA. RESULTS: The study sample comprised of 52 BCLP patients with 26 having PSOA and 26 did not having PSOA. Among these patients, those who had PSOA had significant shorter length of PNS-ANS (3.69 mm; p= 0.04) and Co-A (8.38 mm; p=0.04) compared to those who did not have PSOA. However, there were no significant difference in the length measurements between passive and active PSOA users. CONCLUSION: The usage of PSOA gives a shorter maxillary length in the facial growth of bilateral cleft patients. This study proved the effectiveness of PSOA on facial growth of cleft patients in local population.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80537516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2182
H. Wong, S. Harith, P. L. Lua, Khairul Azmi Ibrahim
INTRODUCTION: Despite a higher risk of a recurrent cerebrovascular event, many stroke survivors failed to achieve their targeted treatment goals. This study aimed to examine the effectiveness of a dietitian-led healthy lifestyle educational package targeted at improving stroke risk factors and lifestyle practices among stroke survivors. MATERIALS AND METHODS: A quasi-experimental pilot study was undertaken in general medical wards of two public hospitals in Malaysia. Patients were allocated into either intervention or control groups based on the week of screening. Adults aged more than 18 years old, with first-ever stroke, and the willingness of caregivers to participate were included. The intervention group (patient-caregiver dyad) received three dietitian-led healthy lifestyle education sessions underpinned with Health Belief Model and Reflection and Refractive theories and was followed up for three months. The control group received the usual stroke care. Outcome variables included blood pressure, body mass index, waist circumference, dietary intake, physical activity levels, smoking status, alcohol consumption, malnutrition risk, and health-related quality of life. McNemar, Chi-square, and repeated measures Analysis of Covariance tests were conducted to examine the within - and between-group differences. RESULTS: A total of 54 participants (27 in each group) were included in this study. The intervention group had a significantly lower intake of sugar (P=0.002, effect size=0.50) and sodium (P=0.044, effect size=0.31), a lower proportion of active smokers (7% versus 33%, P=0.039), lesser sitting time (P=0.012, effect size=0.37), and lower proportion having pain/discomfort issues (22% versus 63%, P=0.005) than the control group. CONCLUSION: Early dietitian-led lifestyle modification sessions underpinned with behavioural change theories paired with the involvement of family members appear to be beneficial among stroke survivors.
{"title":"Effectiveness of a Dietitian-led Healthy Lifestyle Education Package in Improving Health Behaviours of Stroke Survivors in Malaysia: A Pilot Study","authors":"H. Wong, S. Harith, P. L. Lua, Khairul Azmi Ibrahim","doi":"10.31436/imjm.v22i2.2182","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2182","url":null,"abstract":"INTRODUCTION: Despite a higher risk of a recurrent cerebrovascular event, many stroke survivors failed to achieve their targeted treatment goals. This study aimed to examine the effectiveness of a dietitian-led healthy lifestyle educational package targeted at improving stroke risk factors and lifestyle practices among stroke survivors. MATERIALS AND METHODS: A quasi-experimental pilot study was undertaken in general medical wards of two public hospitals in Malaysia. Patients were allocated into either intervention or control groups based on the week of screening. Adults aged more than 18 years old, with first-ever stroke, and the willingness of caregivers to participate were included. The intervention group (patient-caregiver dyad) received three dietitian-led healthy lifestyle education sessions underpinned with Health Belief Model and Reflection and Refractive theories and was followed up for three months. The control group received the usual stroke care. Outcome variables included blood pressure, body mass index, waist circumference, dietary intake, physical activity levels, smoking status, alcohol consumption, malnutrition risk, and health-related quality of life. McNemar, Chi-square, and repeated measures Analysis of Covariance tests were conducted to examine the within - and between-group differences. RESULTS: A total of 54 participants (27 in each group) were included in this study. The intervention group had a significantly lower intake of sugar (P=0.002, effect size=0.50) and sodium (P=0.044, effect size=0.31), a lower proportion of active smokers (7% versus 33%, P=0.039), lesser sitting time (P=0.012, effect size=0.37), and lower proportion having pain/discomfort issues (22% versus 63%, P=0.005) than the control group. CONCLUSION: Early dietitian-led lifestyle modification sessions underpinned with behavioural change theories paired with the involvement of family members appear to be beneficial among stroke survivors.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85963695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2086
Fatin Aina Abu Bakar, T. A. Tengku Ismail, Suhaily Mohd Hairon, S. S. Mohd Yusoff
INTRODUCTION: The Risk Perception Survey on Developing Diabetes questionnaire identifies how women with gestational diabetes mellitus (GDM) perceived the risk of developing diabetes after their pregnancy has ended. The objective of this study was to translate and validate an English questionnaire into Malay. MATERIALS AND METHODS: A cross-sectional study was conducted from February 2019 to July 2019 among 200 women with GDM who attended public health clinics in Johor Bahru, Malaysia. The original author of the questionnaire granted us permission to use for this study. The translation of the questionnaire, content, and face validation was performed. It was followed by confirmatory factor analysis using R version 3.5.3 and item analysis for the knowledge domain. The composite reliability and internal consistency reliability using Cronbach alpha were also computed. RESULTS: The Malay version consists of 20 items in five domains; personal control (2 items), optimistic bias (2 items), knowledge of diabetes risk factors (11 items), benefits and barriers of preventive behaviour (3 items), and risk perception (2 items). Confirmatory factor analysis confirmed the structure of the model. The goodness-of-fit values were adequate [comparative fit index=0.994, Tucker-Lewis Index=0.990, standardized root mean square residual=0.038, root mean square of approximation=0.021 (90% CI: 0.000,0.064)]. The four domains had composite reliability values between 0.60 and 0.88. The Cronbach alpha value for knowledge of diabetes risk factors domain was 0.843. CONCLUSION: The translated Malay questionnaire is valid and reliable to assess the perception of women with GDM towards their future risk of getting diabetes.
{"title":"Risk Perception Survey on Developing Diabetes Questionnaire: Translation and Validation of the Malay Version","authors":"Fatin Aina Abu Bakar, T. A. Tengku Ismail, Suhaily Mohd Hairon, S. S. Mohd Yusoff","doi":"10.31436/imjm.v22i2.2086","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2086","url":null,"abstract":"INTRODUCTION: The Risk Perception Survey on Developing Diabetes questionnaire identifies how women with gestational diabetes mellitus (GDM) perceived the risk of developing diabetes after their pregnancy has ended. The objective of this study was to translate and validate an English questionnaire into Malay. MATERIALS AND METHODS: A cross-sectional study was conducted from February 2019 to July 2019 among 200 women with GDM who attended public health clinics in Johor Bahru, Malaysia. The original author of the questionnaire granted us permission to use for this study. The translation of the questionnaire, content, and face validation was performed. It was followed by confirmatory factor analysis using R version 3.5.3 and item analysis for the knowledge domain. The composite reliability and internal consistency reliability using Cronbach alpha were also computed. RESULTS: The Malay version consists of 20 items in five domains; personal control (2 items), optimistic bias (2 items), knowledge of diabetes risk factors (11 items), benefits and barriers of preventive behaviour (3 items), and risk perception (2 items). Confirmatory factor analysis confirmed the structure of the model. The goodness-of-fit values were adequate [comparative fit index=0.994, Tucker-Lewis Index=0.990, standardized root mean square residual=0.038, root mean square of approximation=0.021 (90% CI: 0.000,0.064)]. The four domains had composite reliability values between 0.60 and 0.88. The Cronbach alpha value for knowledge of diabetes risk factors domain was 0.843. CONCLUSION: The translated Malay questionnaire is valid and reliable to assess the perception of women with GDM towards their future risk of getting diabetes.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84033354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2168
Siti Noorwanie Abdul Hamid, N. Zakaria, F. A. Abdul Majid, A. F. I. Awang, S. N. Zainol, Ain Nabihah Zainudin, Siti Nur Hidayah Muhamad
INTRODUCTION: The study aimed to assess the safety and nutraceutical properties of ALLURATM related to women’s health and skin beautification. MATERIALS AND METHODS: Determinations of total phenolic (TPC) and flavonoid contents (TFC) were done using the colorimetric method, followed by the identification of gallic acid via highperformance liquid chromatography (HPLC). Antioxidant activity was analyzed using 2,2 -diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radicals while its anti-inflammatory activity was measured using enzymelinked immunosorbent assay (ELISA). Anti-aging and whitening effects were determined by porcine elastase and mushroom tyrosinase activities, respectively. Skin cell growth promotion and rejuvenation were evaluated using in vitro scratch assay. Cytotoxicity assay was done using HSF1184 and 3T3 BALB/c cell lines. While, acute toxicity test was done on two groups (control and treatment) of six Wistar rats each. The nutraceutical properties were evaluated based on proximate analysis. RESULTS: ALLURATM exhibited DPPH-IC50 values of 180.40 µg/mL and ABTS-IC50 value of 174.40 µg/mL. TPC and TFC were 67.31 mg GAE/g extract and 43.21 mg CE/g extract, respectively while 10.98 mg/g of gallic acid were quantified. ALLURATM reduced pro-inflammatory cytokines of TNF-α and IL-6 and showed anti-aging (IC50-162.40 µg/mL) and whitening effects (IC50- 167.70 µg/mL). ALLURA™ also increased the proliferation of HSF1184 (≤ 1000 µg/ mL), producing significant secretion of epidermal growth factor (EGF) and shown to be non-cytotoxic. No mortality was observed at the highest dose of 2000 mg/kg b.w.t. nor the behavioral and morphological changes in rats. The proximate analysis resulted in high content of moisture and low calories. CONCLUSION: These findings provided preliminary reports for the first time on the functionality of ALLURA™ for its anti-inflammatory, antioxidant, and nutraceutical properties.
{"title":"In vitro and In vivo Assessments on Nutraceutical and Safety of Herb-Fruit Based Drink on Female Wistar Rats","authors":"Siti Noorwanie Abdul Hamid, N. Zakaria, F. A. Abdul Majid, A. F. I. Awang, S. N. Zainol, Ain Nabihah Zainudin, Siti Nur Hidayah Muhamad","doi":"10.31436/imjm.v22i2.2168","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2168","url":null,"abstract":"INTRODUCTION: The study aimed to assess the safety and nutraceutical properties of ALLURATM related to women’s health and skin beautification. MATERIALS AND METHODS: Determinations of total phenolic (TPC) and flavonoid contents (TFC) were done using the colorimetric method, followed by the identification of gallic acid via highperformance liquid chromatography (HPLC). Antioxidant activity was analyzed using 2,2 -diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radicals while its anti-inflammatory activity was measured using enzymelinked immunosorbent assay (ELISA). Anti-aging and whitening effects were determined by porcine elastase and mushroom tyrosinase activities, respectively. Skin cell growth promotion and rejuvenation were evaluated using in vitro scratch assay. Cytotoxicity assay was done using HSF1184 and 3T3 BALB/c cell lines. While, acute toxicity test was done on two groups (control and treatment) of six Wistar rats each. The nutraceutical properties were evaluated based on proximate analysis. RESULTS: ALLURATM exhibited DPPH-IC50 values of 180.40 µg/mL and ABTS-IC50 value of 174.40 µg/mL. TPC and TFC were 67.31 mg GAE/g extract and 43.21 mg CE/g extract, respectively while 10.98 mg/g of gallic acid were quantified. ALLURATM reduced pro-inflammatory cytokines of TNF-α and IL-6 and showed anti-aging (IC50-162.40 µg/mL) and whitening effects (IC50- 167.70 µg/mL). ALLURA™ also increased the proliferation of HSF1184 (≤ 1000 µg/ mL), producing significant secretion of epidermal growth factor (EGF) and shown to be non-cytotoxic. No mortality was observed at the highest dose of 2000 mg/kg b.w.t. nor the behavioral and morphological changes in rats. The proximate analysis resulted in high content of moisture and low calories. CONCLUSION: These findings provided preliminary reports for the first time on the functionality of ALLURA™ for its anti-inflammatory, antioxidant, and nutraceutical properties.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81900889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2110
S. George, Theingi Maung Maung, H. Narayanam, S. S. Latt
INTRODUCTION: Every learner has a way of interacting with the knowledge they have acquired, and this interaction is called a learning approach. Knowing the student's favorite learning methods will facilitate them with directions tailored to their unique needs. This study aims to measure the differences in learning approaches among first-year medical and dental students of a private university, in Malaysia. MATERIALS AND METHODS: A three-month analytical cross-sectional study was undertaken among the interested students. The self-administered, validated ASSIST questionnaire was used to measure students’ preferred learning approaches. The Pearson correlation and independent sample t-test were used to analyze the data with SPSS software. The p-value was set at less than 0.05 to indsicate a significant level. RESULTS: A total of 225 students participated, out of which 150 (66.7%) respondents were medical students, and 75 (33.3%) were dental students. Medical students reported a favoured considerably deep learning approach over dental students (t=2.874, p=0.004), and preferred the strategic approach to learning (t=2.051, p=0.041). There was a weak and no significant correlation between the concept of learning (learning as reproducing knowledge [RK] p=0.377, learning involving personal understanding [PU] p=0.269), self-rating (p=0.824), and the surface learning approach. Both medical and dental students have no significant difference in surface learning approach with t =0.556 and p=0.579. CONCLUSION: Medical students favoured deep and strategic learning over dental students. While there was no significant difference in the surface learning approach, the deep and strategic learning approaches were substantially connected with the notion of learning, types of courses/teaching, and self-rating. The knowledge of learning approaches will assist educators in making efforts to address students through successful teaching strategies. Once teachers understand the need to accommodate individual strengths and needs, they will devise appropriate new teaching methods.
{"title":"Evaluation of Learning Approaches among First-Year Medical and Dental Students of a Private University, in Malaysia","authors":"S. George, Theingi Maung Maung, H. Narayanam, S. S. Latt","doi":"10.31436/imjm.v22i2.2110","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2110","url":null,"abstract":"INTRODUCTION: Every learner has a way of interacting with the knowledge they have acquired, and this interaction is called a learning approach. Knowing the student's favorite learning methods will facilitate them with directions tailored to their unique needs. This study aims to measure the differences in learning approaches among first-year medical and dental students of a private university, in Malaysia. MATERIALS AND METHODS: A three-month analytical cross-sectional study was undertaken among the interested students. The self-administered, validated ASSIST questionnaire was used to measure students’ preferred learning approaches. The Pearson correlation and independent sample t-test were used to analyze the data with SPSS software. The p-value was set at less than 0.05 to indsicate a significant level. RESULTS: A total of 225 students participated, out of which 150 (66.7%) respondents were medical students, and 75 (33.3%) were dental students. Medical students reported a favoured considerably deep learning approach over dental students (t=2.874, p=0.004), and preferred the strategic approach to learning (t=2.051, p=0.041). There was a weak and no significant correlation between the concept of learning (learning as reproducing knowledge [RK] p=0.377, learning involving personal understanding [PU] p=0.269), self-rating (p=0.824), and the surface learning approach. Both medical and dental students have no significant difference in surface learning approach with t =0.556 and p=0.579. CONCLUSION: Medical students favoured deep and strategic learning over dental students. While there was no significant difference in the surface learning approach, the deep and strategic learning approaches were substantially connected with the notion of learning, types of courses/teaching, and self-rating. The knowledge of learning approaches will assist educators in making efforts to address students through successful teaching strategies. Once teachers understand the need to accommodate individual strengths and needs, they will devise appropriate new teaching methods.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83998197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2186
N. S. Ahmad, Norsuriani Samsudin, F. Ooi, A. Abdul Kadir, N. Kassim
INTRODUCTION: Obesity has been associated to persistent oxidative stress and inflammation that could lead to chronic diseases. MATERIALS AND METHODS: Sixty[1]eight overweight and obese participants aged 29.03 ± 6.02 years old were randomly assigned, with 17 participants per group, into sedentary control (C), L-carnitine supplement alone (S), exercise alone (E), and combined L-carnitine supplementation and exercise (SE) groups. The participants in S and SE groups took one tablet of 1000 mg of L-carnitine every day. The E and SE groups performed brisk walking exercise for 30 minutes at 50% HRmax followed by Tabata exercise for 10 to 20 minutes per session, 3 sessions per week. During pre- and post-tests, blood markers of participants were assessed to determine their reactive oxygen species (ROS), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and interleukin-6 (IL-6) levels. All the observed parameters were analysed using two-way mixed ANOVA for repeated measures to determine significant differences within and between the groups and comparisons of mean differences were performed using one way ANOVA. RESULTS: Results showed that there were significant decreases in ROS and MDA in the S, E, and SE groups at post-test after 12 weeks of intervention. The greatest reduction of these parameters were observed in SE group among all groups. At the post-test, both CAT and SOD levels increased in the S, E, and SE groups. Regarding IL-6, it was found to be increased in C and E groups. In contrast, there were significant decreases in S and SE groups following the intervention. CONCLUSION: Twelve weeks of L-carnitine supplementation and engagement in brisk walking and Tabata exercise had significant improvement on oxidative stress, antioxidant, and anti-inflammatory responses in overweight and obese individuals.
{"title":"Effects of Combined L-Carnitine Supplementation and Moderate-Intensity Exercises on Oxidative Stress, Antioxidant, and Anti-Inflammatory Responses in Overweight and Obese Individuals: A Randomized Controlled Trial","authors":"N. S. Ahmad, Norsuriani Samsudin, F. Ooi, A. Abdul Kadir, N. Kassim","doi":"10.31436/imjm.v22i2.2186","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2186","url":null,"abstract":"INTRODUCTION: Obesity has been associated to persistent oxidative stress and inflammation that could lead to chronic diseases. MATERIALS AND METHODS: Sixty[1]eight overweight and obese participants aged 29.03 ± 6.02 years old were randomly assigned, with 17 participants per group, into sedentary control (C), L-carnitine supplement alone (S), exercise alone (E), and combined L-carnitine supplementation and exercise (SE) groups. The participants in S and SE groups took one tablet of 1000 mg of L-carnitine every day. The E and SE groups performed brisk walking exercise for 30 minutes at 50% HRmax followed by Tabata exercise for 10 to 20 minutes per session, 3 sessions per week. During pre- and post-tests, blood markers of participants were assessed to determine their reactive oxygen species (ROS), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and interleukin-6 (IL-6) levels. All the observed parameters were analysed using two-way mixed ANOVA for repeated measures to determine significant differences within and between the groups and comparisons of mean differences were performed using one way ANOVA. RESULTS: Results showed that there were significant decreases in ROS and MDA in the S, E, and SE groups at post-test after 12 weeks of intervention. The greatest reduction of these parameters were observed in SE group among all groups. At the post-test, both CAT and SOD levels increased in the S, E, and SE groups. Regarding IL-6, it was found to be increased in C and E groups. In contrast, there were significant decreases in S and SE groups following the intervention. CONCLUSION: Twelve weeks of L-carnitine supplementation and engagement in brisk walking and Tabata exercise had significant improvement on oxidative stress, antioxidant, and anti-inflammatory responses in overweight and obese individuals.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76003752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.31436/imjm.v22i2.2170
Siti Hajar Mohamed Zain, S. R. Mohd Arifin, Hanida Hani Mokhtar, M. S. Nurumal, Mohamad Che' Man
The alarming number of smokers have increased public health concerns regarding the effects of second-hand smoke (SHS) on non-smokers, especially amongst pregnant women and unborn babies. This paper aims to review the existing interventions used to reduce SHS exposure amongst non-smoking pregnant women. This review was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) review method. Published articles were identified through three databases: ProQuest, Science Direct, and Scopus within the 2010–2021 timeframe. Articles related to the intervention to reduce SHS exposure among non-smoking pregnant women were included. Nine studies were identified and reviewed. Most of the preventive interventions primarily focused on pregnant women as the target group, whereas a few interventions directly focused on changing the smoking behaviour of their spouses. This review suggests that using theories as a foundation in designing the intervention effectively reduces exposure to SHS among non-smoking pregnant women. The main limitation as reported by most studies was the lack of biochemical verification. Thus, future intervention should consider both pregnant women and their smoking spouses as the target group and include relevant theories in clinical intervention.
{"title":"Preventive Interventions to Reduce Second-Hand Smoke Exposure Among Non-Smoking Pregnant Women: A Systematic Review","authors":"Siti Hajar Mohamed Zain, S. R. Mohd Arifin, Hanida Hani Mokhtar, M. S. Nurumal, Mohamad Che' Man","doi":"10.31436/imjm.v22i2.2170","DOIUrl":"https://doi.org/10.31436/imjm.v22i2.2170","url":null,"abstract":"The alarming number of smokers have increased public health concerns regarding the effects of second-hand smoke (SHS) on non-smokers, especially amongst pregnant women and unborn babies. This paper aims to review the existing interventions used to reduce SHS exposure amongst non-smoking pregnant women. This review was guided by the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analyses) review method. Published articles were identified through three databases: ProQuest, Science Direct, and Scopus within the 2010–2021 timeframe. Articles related to the intervention to reduce SHS exposure among non-smoking pregnant women were included. Nine studies were identified and reviewed. Most of the preventive interventions primarily focused on pregnant women as the target group, whereas a few interventions directly focused on changing the smoking behaviour of their spouses. This review suggests that using theories as a foundation in designing the intervention effectively reduces exposure to SHS among non-smoking pregnant women. The main limitation as reported by most studies was the lack of biochemical verification. Thus, future intervention should consider both pregnant women and their smoking spouses as the target group and include relevant theories in clinical intervention.","PeriodicalId":13474,"journal":{"name":"IIUM Medical Journal Malaysia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78733144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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