Pub Date : 2023-04-08DOI: 10.20473/ijtid.v11i1.43097
C. Purnamasidhi, I. Somia, D. Júnior, R. Suteja, I. Adiputra, G. Purnama, I. Weisnawa, Jerry, P. Wulandari, D. Shanti, I. Diksha
Elderly COVID-19 patients have been associated with worse outcomes and have been presented with the highest mortality rate. However, studies on the clinical features and the differences between critical and non-critical elderly COVID-19 patients in Indonesia and even other countries are still lacking and rare. In this retrospective study, the epidemiological and clinical features of critical and non-critical elderly COVID-19 patients admitted to Udayana University Academic Hospital between April 2020 and March 2021 were analyzed and then compared. Of the 280 medical records analyzed, 60.7% were male and the median age was 65.0 years old. Based on the medical records, 18.2% of elderly patients met our criteria of critical patients. The most common symptoms presented in both category upon admission included fever and coughing. The most common comorbidity found in critical patients was heart disease and hypertension in non-critical patients. Laboratory results differences included leukocytes, neutrophils, lymphocytes, Neutrophil-to-Lymphocyte Ratio, platelets, SGOT, SGPT, and urea. Only 9.9% of critical patients and 6.1% of non-critical patients were given antiviral therapy. In contrast, 68.6% of critical patients and 76% of non-critical patients were given antibiotics. The mortality rate in critical patients was 70.6% and 0.4% in non-critical patients. Based on the results, a multimodal approach in the treatment of elderly COVID-19 patients is very essential. The higher mortality rate in elderly patients should be able to be reduced by giving early and timely antiviral therapy with the addition of effective choice of drugs.
{"title":"Epidemiological and Clinical Features of Critical and Non-Critical Elderly COVID-19 Patients in Udayana University Academic Hospital: A Retrospective Study","authors":"C. Purnamasidhi, I. Somia, D. Júnior, R. Suteja, I. Adiputra, G. Purnama, I. Weisnawa, Jerry, P. Wulandari, D. Shanti, I. Diksha","doi":"10.20473/ijtid.v11i1.43097","DOIUrl":"https://doi.org/10.20473/ijtid.v11i1.43097","url":null,"abstract":"Elderly COVID-19 patients have been associated with worse outcomes and have been presented with the highest mortality rate. However, studies on the clinical features and the differences between critical and non-critical elderly COVID-19 patients in Indonesia and even other countries are still lacking and rare. In this retrospective study, the epidemiological and clinical features of critical and non-critical elderly COVID-19 patients admitted to Udayana University Academic Hospital between April 2020 and March 2021 were analyzed and then compared. Of the 280 medical records analyzed, 60.7% were male and the median age was 65.0 years old. Based on the medical records, 18.2% of elderly patients met our criteria of critical patients. The most common symptoms presented in both category upon admission included fever and coughing. The most common comorbidity found in critical patients was heart disease and hypertension in non-critical patients. Laboratory results differences included leukocytes, neutrophils, lymphocytes, Neutrophil-to-Lymphocyte Ratio, platelets, SGOT, SGPT, and urea. Only 9.9% of critical patients and 6.1% of non-critical patients were given antiviral therapy. In contrast, 68.6% of critical patients and 76% of non-critical patients were given antibiotics. The mortality rate in critical patients was 70.6% and 0.4% in non-critical patients. Based on the results, a multimodal approach in the treatment of elderly COVID-19 patients is very essential. The higher mortality rate in elderly patients should be able to be reduced by giving early and timely antiviral therapy with the addition of effective choice of drugs.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47497293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.20473/ijtid.v11i1.34097
R. Ruby, Erlangga Saputra Arifin, S. Kurniawan, S. S. Surja
Invasive candidiasis (IC) has a high mortality rate of 70%, thus diagnosis should be established without delay. Given its fast result, serological test such as β-d-glucan (BDG) test is one alternative diagnosis modalities. However, it lacks specificity. Candida albicans germ tube antibody (CAGTA) test is an alternative serological test which has a high sensitivity of 76.2% and specificity of 80.3%. Manufacturing CAGTA serological test requires provision of specific germ tube antigen. In this study, various culture media were tested to find the best media for germ tube induction. This study was an experimental in vitro study. The number and length of the germ tube were recorded in two- and three-hour incubation periods. A total of six samples containing one C. albicans ATCC 90028, four C. albicans wild type strains, and one C. krusei wild type strain were used. Nine media were tested to induce germ tube formation: human and sheep serum, fetal bovine serum, mueller hinton agar and broth, tryptic soy agar and broth, brain heart infusion agar and broth. At both incubation periods, the medium with the highest number of germ tube was human serum (p=0.001 and p=0). The longest germ tube was found in sheep serum at two-hour incubation period (p=0.005). Mueller hinton broth (MHB) showed comparable results with human and sheep serum (p>0.05). Human serum is a superior inducer of morphogenesis. However, the use of MHB is recommended in this study, since provision of fresh human and sheep serum on a regular basis is impractical.
{"title":"Germ Tube Induction Test Comparing Total of Six Liquid and Three Solid Media in Candida albicans","authors":"R. Ruby, Erlangga Saputra Arifin, S. Kurniawan, S. S. Surja","doi":"10.20473/ijtid.v11i1.34097","DOIUrl":"https://doi.org/10.20473/ijtid.v11i1.34097","url":null,"abstract":"Invasive candidiasis (IC) has a high mortality rate of 70%, thus diagnosis should be established without delay. Given its fast result, serological test such as β-d-glucan (BDG) test is one alternative diagnosis modalities. However, it lacks specificity. Candida albicans germ tube antibody (CAGTA) test is an alternative serological test which has a high sensitivity of 76.2% and specificity of 80.3%. Manufacturing CAGTA serological test requires provision of specific germ tube antigen. In this study, various culture media were tested to find the best media for germ tube induction. This study was an experimental in vitro study. The number and length of the germ tube were recorded in two- and three-hour incubation periods. A total of six samples containing one C. albicans ATCC 90028, four C. albicans wild type strains, and one C. krusei wild type strain were used. Nine media were tested to induce germ tube formation: human and sheep serum, fetal bovine serum, mueller hinton agar and broth, tryptic soy agar and broth, brain heart infusion agar and broth. At both incubation periods, the medium with the highest number of germ tube was human serum (p=0.001 and p=0). The longest germ tube was found in sheep serum at two-hour incubation period (p=0.005). Mueller hinton broth (MHB) showed comparable results with human and sheep serum (p>0.05). Human serum is a superior inducer of morphogenesis. However, the use of MHB is recommended in this study, since provision of fresh human and sheep serum on a regular basis is impractical.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46897869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.20473/ijtid.v11i1.42672
Laura Wihanto, G. Waworuntu, C. P. Tedyanto, Heni Puspitasari
The various infection routes of Toxoplasma gondii that are close to daily life strongly support the incidence of toxoplasmosis. The emergence of drug-resistant Toxoplasma gondii strains raises future concerns. Moringa leaf ethanol extract has been shown to have several anti-pathogen activities, which could have an anti-Toxoplasma effect. This research was conducted to analyze the anti-Toxoplasma effect of moringa leaf ethanol extract against tachyzoites replication in Toxoplasma gondii and the correlation between extract doses with the number of tachyzoites. Mice were divided into five groups. The negative control group (Group I) received CMC-Na solution. The positive control group (Group II) received spiramycin 100 mg/kg BW. The treatment groups received moringa leaf ethanol extract 250 mg/kg BW (group III), 500 mg/kg BW (group IV), and 1000 mg/kg BW (group V), respectively. Mice were injected with 1 x 105 tachyzoites/0.1 mL/mice intraperitoneally on the first day. Moringa leaf ethanol extract and spiramycin were given orally once daily for three days. The number of tachyzoites in the intraperitoneal fluid was calculated on the fifth day. The results have shown that there were significantly lower differences (P < 0.05) in group IV (P = 0.021) and group V (P = 0.022) compared to group I. There was also a significant negative correlation between the extract doses and the number of tachyzoites (P = 0.000; r = -0.781). Moringa oleifera leaf ethanol extract has an anti-Toxoplasma effect by inhibiting the tachyzoite replication at 500 mg/kg BW and 1000 mg/kg BW.
{"title":"Moringa oleifera Leaf Ethanol Extract Inhibits Toxoplasma gondii Tachyzoites Replication","authors":"Laura Wihanto, G. Waworuntu, C. P. Tedyanto, Heni Puspitasari","doi":"10.20473/ijtid.v11i1.42672","DOIUrl":"https://doi.org/10.20473/ijtid.v11i1.42672","url":null,"abstract":"The various infection routes of Toxoplasma gondii that are close to daily life strongly support the incidence of toxoplasmosis. The emergence of drug-resistant Toxoplasma gondii strains raises future concerns. Moringa leaf ethanol extract has been shown to have several anti-pathogen activities, which could have an anti-Toxoplasma effect. This research was conducted to analyze the anti-Toxoplasma effect of moringa leaf ethanol extract against tachyzoites replication in Toxoplasma gondii and the correlation between extract doses with the number of tachyzoites. Mice were divided into five groups. The negative control group (Group I) received CMC-Na solution. The positive control group (Group II) received spiramycin 100 mg/kg BW. The treatment groups received moringa leaf ethanol extract 250 mg/kg BW (group III), 500 mg/kg BW (group IV), and 1000 mg/kg BW (group V), respectively. Mice were injected with 1 x 105 tachyzoites/0.1 mL/mice intraperitoneally on the first day. Moringa leaf ethanol extract and spiramycin were given orally once daily for three days. The number of tachyzoites in the intraperitoneal fluid was calculated on the fifth day. The results have shown that there were significantly lower differences (P < 0.05) in group IV (P = 0.021) and group V (P = 0.022) compared to group I. There was also a significant negative correlation between the extract doses and the number of tachyzoites (P = 0.000; r = -0.781). Moringa oleifera leaf ethanol extract has an anti-Toxoplasma effect by inhibiting the tachyzoite replication at 500 mg/kg BW and 1000 mg/kg BW.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45201831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-08DOI: 10.20473/ijtid.v11i1.40266
Karin Dhia Fahmita, Gatot Soegiarto, L. Wulandari, D. Purnomosari
To determine impact of hypertension and cardiovascular diseases towards effectivity and safety of COVID-19 vaccination. Systematic review based on PRISMA statement was done. Searching was conducted in PubMed, ScienceDirect, Scopus, and ProQuest and resulting in 6 studies involving 4,053 participants which deemed on good quality according to Joanna Briggs Institute tools for critical appraisal. After thorough analysis, we found that two out of four studies assessing mRNA-based vaccine found out that hypertension lower antibody response significantly. Two out of two studies assessing inactivated virus vaccine shown that hypertensive patients tend to have lower antibody titers compared to control. One of studies mentioned above found that antibody titer was not different between populations with cardiovascular diseases and control.Hypertension lessened response to COVID-19 vaccination regardless of vaccine type used. However, lack of studies on cardiovascular disease suggested that more studies should be conducted, along with hypertension, in-order to make meta-analysis possible to provide better evidence.
{"title":"Impact of Hypertension and Cardiovascular Diseases to Immune Response in COVID-19 Vaccination: A Systematic Review","authors":"Karin Dhia Fahmita, Gatot Soegiarto, L. Wulandari, D. Purnomosari","doi":"10.20473/ijtid.v11i1.40266","DOIUrl":"https://doi.org/10.20473/ijtid.v11i1.40266","url":null,"abstract":"To determine impact of hypertension and cardiovascular diseases towards effectivity and safety of COVID-19 vaccination. Systematic review based on PRISMA statement was done. Searching was conducted in PubMed, ScienceDirect, Scopus, and ProQuest and resulting in 6 studies involving 4,053 participants which deemed on good quality according to Joanna Briggs Institute tools for critical appraisal. After thorough analysis, we found that two out of four studies assessing mRNA-based vaccine found out that hypertension lower antibody response significantly. Two out of two studies assessing inactivated virus vaccine shown that hypertensive patients tend to have lower antibody titers compared to control. One of studies mentioned above found that antibody titer was not different between populations with cardiovascular diseases and control.Hypertension lessened response to COVID-19 vaccination regardless of vaccine type used. However, lack of studies on cardiovascular disease suggested that more studies should be conducted, along with hypertension, in-order to make meta-analysis possible to provide better evidence.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45361012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.20473/ijtid.v10i3.18978
D. Agustina, Endiningtyas Cahyaningrum, Cicih Komariah, I. Semita, Yudha Ananta Khaerul Putra
Surgical site infection (SSI) in open fracture is often caused by bacterial contamination in the management of open fracture. Because of that, one of the most important thing in handling open fracture is debridement. Prophylactic antibiotics given are Cephalosporin and Aminoglycosides. Post-debridement culture is important in predicting the incidence of infection. One of the bacteria that is often found in post-debridement culture is Klebsiella spp. which can produce ESBL to fight β-lactam class of antibiotics. The purpose of this study was to determine antibiotic sensitivity against Klebsiella spp. in the post-debridement culture of cases of open fractures in the emergency department of dr. Soebandi hospital Jember. This study uses a laboratory exploratory research design. The sample of this study was the isolate of Klebsiella spp. which amounts to 5 from post debridement culture of open fracture patients in the emergency department of dr. Soebandi hospital Jember from March to May 2019.The method used is diffusion (Kirby Baurer) by matching using the CLSI standard table to determine sensitive, intermediate, or resistant. The results of this study showed that most antibiotics had resistance to Klebsiella spp., including β-lactam antibiotics, such as Amoxicillin, Ceftriaxone, Cefixime, Penicilin, Meropenem, and Cefadroxil. Vancomycin antibiotics are still sensitive to Klebsiella spp. in all patients. Gentamicin, Ciprofloxacin, Tetracycline, and Chloramphenicol antibiotics were sensitive in 1 patient. Erythromycin intermediates antibiotics against Klebsiella spp.. The conclusion of this study is that all β-lactam group antibiotics are resistant to Klebsiella spp while the most sensitive antibiotic is Vancomycin.
{"title":"Antibiotic Sensitivity Against Klebsiella spp. in the Post Debridement Culture an Open Fracture in Emergency Department of dr. Soebandi Hospital Jember","authors":"D. Agustina, Endiningtyas Cahyaningrum, Cicih Komariah, I. Semita, Yudha Ananta Khaerul Putra","doi":"10.20473/ijtid.v10i3.18978","DOIUrl":"https://doi.org/10.20473/ijtid.v10i3.18978","url":null,"abstract":"Surgical site infection (SSI) in open fracture is often caused by bacterial contamination in the management of open fracture. Because of that, one of the most important thing in handling open fracture is debridement. Prophylactic antibiotics given are Cephalosporin and Aminoglycosides. Post-debridement culture is important in predicting the incidence of infection. One of the bacteria that is often found in post-debridement culture is Klebsiella spp. which can produce ESBL to fight β-lactam class of antibiotics. The purpose of this study was to determine antibiotic sensitivity against Klebsiella spp. in the post-debridement culture of cases of open fractures in the emergency department of dr. Soebandi hospital Jember. This study uses a laboratory exploratory research design. The sample of this study was the isolate of Klebsiella spp. which amounts to 5 from post debridement culture of open fracture patients in the emergency department of dr. Soebandi hospital Jember from March to May 2019.The method used is diffusion (Kirby Baurer) by matching using the CLSI standard table to determine sensitive, intermediate, or resistant. The results of this study showed that most antibiotics had resistance to Klebsiella spp., including β-lactam antibiotics, such as Amoxicillin, Ceftriaxone, Cefixime, Penicilin, Meropenem, and Cefadroxil. Vancomycin antibiotics are still sensitive to Klebsiella spp. in all patients. Gentamicin, Ciprofloxacin, Tetracycline, and Chloramphenicol antibiotics were sensitive in 1 patient. Erythromycin intermediates antibiotics against Klebsiella spp.. The conclusion of this study is that all β-lactam group antibiotics are resistant to Klebsiella spp while the most sensitive antibiotic is Vancomycin.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48573150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.20473/ijtid.v10i3.35072
T. Saad, S. Mishra, Hindeshwari Rai, S. Rawat
COVID-19 has a wide disease spectrum. Different presentations may be seen in different people, with uncertain long-term fate. The amount and longevity of immunity provided among the infected also vary from person to person which might in turn affect the chances of re-infection. Current study tries to uncover the incidence, disease severity and outcomes amongst those who have been previously hospitalized for COVID-19. A prospective cohort study where all patients admitted to intensive care facility at the tertiary care center were followed up for any occurrences of re-infection for more than one year. All cases were followed up telephonically and at scheduled visits to the hospital by trained personnel. A total of 410 cases with a mean age of 59.8 years, including 310 (75.6%) males and 100 (24.4%) females. Among these 410 patients 287 remained alive till the end of study period. Re-infection rates among recovered ICU admitted seriously ill patients were 1.4% whereas the rate of ICU re-admission due to COVID-19 re-infection was only 0.7%. Re-infection among female was 1.1% whereas in male was 1.5%. ICU readmission rate among female was 1.1% while in male was 0.5% only. The chances of re-infection in female were seen less than that in males, but the severity of re-infection in females was found to be higher. COVID-19 re-infection in previously severely infected COVID-19 patient is not so common. The chances of a severe disease among such cases are even rarer.
{"title":"Long-term Consequences, Chances of Re-infection, and Outcomes among Cases Recovered with Severe COVID-19 at a Tertiary Care Centre in Central India","authors":"T. Saad, S. Mishra, Hindeshwari Rai, S. Rawat","doi":"10.20473/ijtid.v10i3.35072","DOIUrl":"https://doi.org/10.20473/ijtid.v10i3.35072","url":null,"abstract":"COVID-19 has a wide disease spectrum. Different presentations may be seen in different people, with uncertain long-term fate. The amount and longevity of immunity provided among the infected also vary from person to person which might in turn affect the chances of re-infection. Current study tries to uncover the incidence, disease severity and outcomes amongst those who have been previously hospitalized for COVID-19. A prospective cohort study where all patients admitted to intensive care facility at the tertiary care center were followed up for any occurrences of re-infection for more than one year. All cases were followed up telephonically and at scheduled visits to the hospital by trained personnel. A total of 410 cases with a mean age of 59.8 years, including 310 (75.6%) males and 100 (24.4%) females. Among these 410 patients 287 remained alive till the end of study period. Re-infection rates among recovered ICU admitted seriously ill patients were 1.4% whereas the rate of ICU re-admission due to COVID-19 re-infection was only 0.7%. Re-infection among female was 1.1% whereas in male was 1.5%. ICU readmission rate among female was 1.1% while in male was 0.5% only. The chances of re-infection in female were seen less than that in males, but the severity of re-infection in females was found to be higher. COVID-19 re-infection in previously severely infected COVID-19 patient is not so common. The chances of a severe disease among such cases are even rarer.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45181078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.20473/ijtid.v10i3.33076
A. Murwani, H. Ashar, Gani Apriningtyas Budiyati
Public Health is the resultant from an balance of individual, agent, and environment problems. Individual knowledge and the ability to adapt to the environment vary greatly. The individual awareness and sensibility towards surroundings will contribute to the public health status. Environmental factor in the raining season with high intensity of rainfall cause some risks such as flood. It can be a disaster and destroy the facilities in the area. This can be a transmission media, a new habitat of insects for certain disease, one of them is Leptospirosis. The condition after flood with low level of clean water facilities can make these bacteria live and reproduce, with warm temperatures, neutral pH of water, humidity and also high rainfall. Leptospirosis cases in Indonesia are sufficiently high which in 2019, there are 845 cases with mortality rate for 16.26%. Some factors may affect the number of the case. This research is aimed to know the factors related to the preventive behavior of leptospirosis. It was held in Public Health Center Berbah Yogyakarta. The method of research is quantitative research with design survey method, quasi experiment. The population is the clients visiting to Public Health Center Berbah, with the average number of clients coming are 200 clients/day. The sample is taken by accidental sampling to the clients with the number of daily visits (50 persons). The result shows, that of five analyzed factors, knowledge is the factor related to the preventive behavior of leptospirosis.
{"title":"Relationship between Knowledge and Preventive Behavior of Leptospirosis in Berbah District Sleman Regency Yogyakarta in 2021","authors":"A. Murwani, H. Ashar, Gani Apriningtyas Budiyati","doi":"10.20473/ijtid.v10i3.33076","DOIUrl":"https://doi.org/10.20473/ijtid.v10i3.33076","url":null,"abstract":"Public Health is the resultant from an balance of individual, agent, and environment problems. Individual knowledge and the ability to adapt to the environment vary greatly. The individual awareness and sensibility towards surroundings will contribute to the public health status. Environmental factor in the raining season with high intensity of rainfall cause some risks such as flood. It can be a disaster and destroy the facilities in the area. This can be a transmission media, a new habitat of insects for certain disease, one of them is Leptospirosis. The condition after flood with low level of clean water facilities can make these bacteria live and reproduce, with warm temperatures, neutral pH of water, humidity and also high rainfall. Leptospirosis cases in Indonesia are sufficiently high which in 2019, there are 845 cases with mortality rate for 16.26%. Some factors may affect the number of the case. This research is aimed to know the factors related to the preventive behavior of leptospirosis. It was held in Public Health Center Berbah Yogyakarta. The method of research is quantitative research with design survey method, quasi experiment. The population is the clients visiting to Public Health Center Berbah, with the average number of clients coming are 200 clients/day. The sample is taken by accidental sampling to the clients with the number of daily visits (50 persons). The result shows, that of five analyzed factors, knowledge is the factor related to the preventive behavior of leptospirosis.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48017946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.20473/ijtid.v10i3.39494
P. Endraswari, N. Mertaniasih, Firman Setiawan, Ayu Lidya Paramita
Bloodstream infections (BSI), caused primarily by multidrug-resistant Escherichia coli, are a significant cause of morbidity and mortality worldwide. This study aims to evaluate the epidemiology of E. coli as a critical pathogen in patients with bloodstream infections in a tertiary referral hospital. This is a retrospective study using a descriptive observational research design. This study used a medical record instrument for bloodstream patients in Dr. Soetomo Hospital's inpatient ward with Gram-negative bacteria results of blood cultures in the Clinical Microbiology Laboratory from April 2021 to September 2021. The observed variables include; antimicrobial sensitivity, patient clinical characteristics, demographic data, clinical diagnosis, and clinical outcome. In 6 months, 276 Gram-negative bloodstream infection patients were treated at Dr. Soetomo Hospital. The proportion of E. coli was 17 %. The main characteristics of patients were over 60 years old (28%), and 54% were female. 63% of E. coli were ESBL, and 9% were carbapenem-resistant microorganisms. High antimicrobial resistance was found in quinolones (100%), ampicillin (93%), piperacillin (74%), tetracycline (72%), ceftriaxone (66%), cefotaxime (65%), ceftazidime (60%), cefazolin (65%), and trimethoprim-sulfamethoxazole (65%). The most common potential determinant profile discovered was linked to immunocompromised status due to malignancy. The high number of antimicrobial-resistant bacteria showed the importance of strict infection control and updated epidemiology data as a guide for empirical antimicrobial therapy.
{"title":"Epidemiology of Escherichia coli as a Critical Pathogen of Bloodstream Infection Patients in Tertiary Referral Hospital","authors":"P. Endraswari, N. Mertaniasih, Firman Setiawan, Ayu Lidya Paramita","doi":"10.20473/ijtid.v10i3.39494","DOIUrl":"https://doi.org/10.20473/ijtid.v10i3.39494","url":null,"abstract":"Bloodstream infections (BSI), caused primarily by multidrug-resistant Escherichia coli, are a significant cause of morbidity and mortality worldwide. This study aims to evaluate the epidemiology of E. coli as a critical pathogen in patients with bloodstream infections in a tertiary referral hospital. This is a retrospective study using a descriptive observational research design. This study used a medical record instrument for bloodstream patients in Dr. Soetomo Hospital's inpatient ward with Gram-negative bacteria results of blood cultures in the Clinical Microbiology Laboratory from April 2021 to September 2021. The observed variables include; antimicrobial sensitivity, patient clinical characteristics, demographic data, clinical diagnosis, and clinical outcome. In 6 months, 276 Gram-negative bloodstream infection patients were treated at Dr. Soetomo Hospital. The proportion of E. coli was 17 %. The main characteristics of patients were over 60 years old (28%), and 54% were female. 63% of E. coli were ESBL, and 9% were carbapenem-resistant microorganisms. High antimicrobial resistance was found in quinolones (100%), ampicillin (93%), piperacillin (74%), tetracycline (72%), ceftriaxone (66%), cefotaxime (65%), ceftazidime (60%), cefazolin (65%), and trimethoprim-sulfamethoxazole (65%). The most common potential determinant profile discovered was linked to immunocompromised status due to malignancy. The high number of antimicrobial-resistant bacteria showed the importance of strict infection control and updated epidemiology data as a guide for empirical antimicrobial therapy.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42004746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.20473/ijtid.v10i3.34898
Alvian Mohamad Yapanto, A. Isnaeni, Khairani Ayu Lestari, Agung B S Satyarsa
COVID-19 transmission necessitates health workers to use personal protective equipment (PPE), especially protective masks when delivering medical services. Long-term use of protective masks might cause facial skin injuries. Our study aims to provide a systematic review to explore the phenomenon and incidence of protective masks induced facial skin injuries in primary healthcare workers. This systematic review was created by obtaining articles from the PubMed database and the Cochrane library from 2020 to 2021, using the keywords "Face skin injury," "Wearing protective masks for a long time," and "Wearing protective masks and facial skin disorders." Inclusion criteria were studies that fully report the phenomenon of wearing protective masks and the incidence of facial skin injuries. One hundred and sixty-eight studies were obtained, but only 14 articles matched the inclusion criteria with more than 10,430 participants from different countries that covered various characteristics of facial skin injuries in primary healthcare workers. The findings obtained dominant characteristics of health workers who experienced facial skin injuries: women, N95 masks, and daily N95 coverage for more than 6 hours (p<0.05). Facial skin injuries are often seen after using protective face masks, as it is used for an extended period as part of a defensive effort during work. Therefore, measures that protect health workers from COVID-19 and prevent health workers from potential injuries of protective masks must be taken into account.
{"title":"Prolonged Use of Protective Masks Induced Facial Skin Injury in Primary Healthcare Workers during COVID-19 Pandemic: A Systematic Review","authors":"Alvian Mohamad Yapanto, A. Isnaeni, Khairani Ayu Lestari, Agung B S Satyarsa","doi":"10.20473/ijtid.v10i3.34898","DOIUrl":"https://doi.org/10.20473/ijtid.v10i3.34898","url":null,"abstract":"COVID-19 transmission necessitates health workers to use personal protective equipment (PPE), especially protective masks when delivering medical services. Long-term use of protective masks might cause facial skin injuries. Our study aims to provide a systematic review to explore the phenomenon and incidence of protective masks induced facial skin injuries in primary healthcare workers. This systematic review was created by obtaining articles from the PubMed database and the Cochrane library from 2020 to 2021, using the keywords \"Face skin injury,\" \"Wearing protective masks for a long time,\" and \"Wearing protective masks and facial skin disorders.\" Inclusion criteria were studies that fully report the phenomenon of wearing protective masks and the incidence of facial skin injuries. One hundred and sixty-eight studies were obtained, but only 14 articles matched the inclusion criteria with more than 10,430 participants from different countries that covered various characteristics of facial skin injuries in primary healthcare workers. The findings obtained dominant characteristics of health workers who experienced facial skin injuries: women, N95 masks, and daily N95 coverage for more than 6 hours (p<0.05). Facial skin injuries are often seen after using protective face masks, as it is used for an extended period as part of a defensive effort during work. Therefore, measures that protect health workers from COVID-19 and prevent health workers from potential injuries of protective masks must be taken into account.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43244921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-09DOI: 10.20473/ijtid.v10i3.34740
Firman Aji Prasetio, M. A. Isfandiari, A. Nugroho
Leptospirosis is a disease that is still a public health problem in the world, however, these cases are rarely reported due to the difficulty of distinguishing clinical symptoms from other endemic diseases and the lack of appropriate laboratory diagnostic services. Pacitan district is one of the districts in East Java that reported Leptospirosis cases for 3 consecutive years from 2017 to 2019. There were total 92 Leptospirosis cases with Case Fatality Rate (CFR) of 15.22% in Pacitan. This study is a descriptive study with a Cross Sectional design that aims to describe the distribution of characteristics of Leptospirosis cases in Pacitan district based on person, place, and time. This study used secondary data from the Pacitan district Health Office, East Java province. The population in this study was all cases with Leptospirosis cases as many as 92 cases recorded in the Pacitan district Health Office data for 2017–2019. The sample of this study were all cases with Leptospirosis as many as 92 cases.The results of the study obtained Leptospirosis cases in Pacitan district in 2017–2019 based on person occured most in the age group of 40–49 years old by 20.45%, in the male sex by 68.48%, and in the population who worked as farmers by 73.58%. Based on the place where the most occured in Tulakan sub district by 52.75%, while based on time, most occured in February, March and April, this is because February to April is the rainy season. Therefore, based on the results of the study, it is necessary to educate the public, especially at risk groups, about the risk factors and Prevention of Leptospirosis.
{"title":"Characteristics of Leptospirosis Cases in Pacitan District, East Java Province","authors":"Firman Aji Prasetio, M. A. Isfandiari, A. Nugroho","doi":"10.20473/ijtid.v10i3.34740","DOIUrl":"https://doi.org/10.20473/ijtid.v10i3.34740","url":null,"abstract":"Leptospirosis is a disease that is still a public health problem in the world, however, these cases are rarely reported due to the difficulty of distinguishing clinical symptoms from other endemic diseases and the lack of appropriate laboratory diagnostic services. Pacitan district is one of the districts in East Java that reported Leptospirosis cases for 3 consecutive years from 2017 to 2019. There were total 92 Leptospirosis cases with Case Fatality Rate (CFR) of 15.22% in Pacitan. This study is a descriptive study with a Cross Sectional design that aims to describe the distribution of characteristics of Leptospirosis cases in Pacitan district based on person, place, and time. This study used secondary data from the Pacitan district Health Office, East Java province. The population in this study was all cases with Leptospirosis cases as many as 92 cases recorded in the Pacitan district Health Office data for 2017–2019. The sample of this study were all cases with Leptospirosis as many as 92 cases.The results of the study obtained Leptospirosis cases in Pacitan district in 2017–2019 based on person occured most in the age group of 40–49 years old by 20.45%, in the male sex by 68.48%, and in the population who worked as farmers by 73.58%. Based on the place where the most occured in Tulakan sub district by 52.75%, while based on time, most occured in February, March and April, this is because February to April is the rainy season. Therefore, based on the results of the study, it is necessary to educate the public, especially at risk groups, about the risk factors and Prevention of Leptospirosis.","PeriodicalId":13538,"journal":{"name":"Indonesian Journal of Tropical and Infectious Disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44773115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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