ABSTRACT Objective: The purpose of this study was to determine the effect of a woman’s age during pregnancy on the incidence of hypospadias in children. Material & Methods: This research is an analytic study with a case control design. The sampling technique is a non-probabilistic technique with consecutive sampling. This study was analyzed by univariate and bivariate. Results: From 62 samples, the number of hypospadias cases was 28 people (90.3%) with woman's age at pregnancy <35 years and 3 people (9.7%) with woman's age at pregnancy ≥ 35 years. While the number of controls was 29 people (93.5%) with woman's age at pregnancy <35 years and 2 people (6.5%) with woman's age at pregnancy ≥ 35 years. Conclusion: There is no significant relationship found in this research between a woman's age at pregnancy and the incidence of hypospadias in children. Keywords: Age, hypospadias, pregnancy.
{"title":"THE EFFECT OF WOMEN'S AGE DURING PREGNANCY ON THE CASE OF HYPOSPADIAS IN CHILDREN <18 YEARS OLD AT ADAM MALIK HOSPITAL IN 2015-2020","authors":"Iqbal Pahlevi Adeputra Nasution, Chrysty Lin","doi":"10.32421/juri.v30i3.812","DOIUrl":"https://doi.org/10.32421/juri.v30i3.812","url":null,"abstract":"ABSTRACT \u0000Objective: The purpose of this study was to determine the effect of a woman’s age during pregnancy on the incidence of hypospadias in children. Material & Methods: This research is an analytic study with a case control design. The sampling technique is a non-probabilistic technique with consecutive sampling. This study was analyzed by univariate and bivariate. Results: From 62 samples, the number of hypospadias cases was 28 people (90.3%) with woman's age at pregnancy <35 years and 3 people (9.7%) with woman's age at pregnancy ≥ 35 years. While the number of controls was 29 people (93.5%) with woman's age at pregnancy <35 years and 2 people (6.5%) with woman's age at pregnancy ≥ 35 years. Conclusion: There is no significant relationship found in this research between a woman's age at pregnancy and the incidence of hypospadias in children. \u0000Keywords: Age, hypospadias, pregnancy.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86111739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objective: This study aims to describe the reconstruction of long ureteric strictures using buccal mucosal patch grafts and to report the short term outcome. Material & Methods: We retrospectively looked at our hospital inpatient and outpatient records of all patients who underwent surgical treatment for benign ureteric strictures. Imaging records and films, histopathological reports were reanalysed. The short term outcomes were also noted. Results: During this 10 years’ study period 8 patients (six Males and two Females) underwent 10 buccal mucosal grafts procedures. The mean age of the patients was 36.25 years and the mean length of the stricture was 7.13.41 cm. There were intraoperative complications noted and none of the patients needed either intra or post-operative blood transfusions. Serum creatinine remained stable at 6 and 12 weeks after surgery. Radioisotope renograms done 12-16 weeks after surgery showed improvement in function on the affected sides in all patients with adequate drainage. Conclusions: Buccal mucosal patch grafting and omental wrapping is feasible, effective, less complicated and associated with good outcomes at short term follow-up. Keywords: Reconstruction, ureteric stricture, buccal mucosa.
{"title":"LONG URETERIC STRICTURES MANAGED BY USING BUCCAL MUCOSAL GRAFTS","authors":"R. Nerli, Keyur Patel, Shreyas Rai, Abhinay Jogula, Pranav Jasuja, Nishant Setya","doi":"10.32421/juri.v30i3.864","DOIUrl":"https://doi.org/10.32421/juri.v30i3.864","url":null,"abstract":"ABSTRACT \u0000Objective: This study aims to describe the reconstruction of long ureteric strictures using buccal mucosal patch grafts and to report the short term outcome. Material & Methods: We retrospectively looked at our hospital inpatient and outpatient records of all patients who underwent surgical treatment for benign ureteric strictures. Imaging records and films, histopathological reports were reanalysed. The short term outcomes were also noted. Results: During this 10 years’ study period 8 patients (six Males and two Females) underwent 10 buccal mucosal grafts procedures. The mean age of the patients was 36.25 years and the mean length of the stricture was 7.13.41 cm. There were intraoperative complications noted and none of the patients needed either intra or post-operative blood transfusions. Serum creatinine remained stable at 6 and 12 weeks after surgery. Radioisotope renograms done 12-16 weeks after surgery showed improvement in function on the affected sides in all patients with adequate drainage. Conclusions: Buccal mucosal patch grafting and omental wrapping is feasible, effective, less complicated and associated with good outcomes at short term follow-up. \u0000Keywords: Reconstruction, ureteric stricture, buccal mucosa.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75604608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objective: To present a case of urethral injury treated in a male adult. Case(s) Presentation: A 48 year old Asian male patient previously involved in a motor vehicle accident presented to the hospital with a chief complaint of pain and bleeding from the genitalia. On examination, it is revealed bleeding from the urethral meatus, pain in touch, palpable bladder, high riding prostate, and a butterfly-shaped bruising on the perineum. X-ray examination demonstrated soft tissue mass in the right scrotal region. The patient is diagnosed with urethral rupture with urinary retention and then underwent ultrasonography-guided cystostomy and perineal hematoma evacuation. The patient is followed-up 1 month later with a complaint of difficulty in voiding and erectile dysfunction. The patient is then diagnosed with urethral stricture and underwent direct vision urethrotomy. Discussion: Urethral injury is a rare type of injury of genitourinary trauma that may cause long term morbidity such as strictures, incontinence, impotence, and infertility. Urethral injury can be classified into posterior urethral injury which is associated with pelvic fracture and anterior urethral injury which is associated with blunt trauma. The gold standard of radiographic examination in urethral injury is dynamic retrograde urethrography. Prompt diagnosis, staging, and selecting intervention must be done for minimalizing complications. Sequelae may also develop which also affects quality of life. The usage of universal health coverage such as BPJS in In Indonesia can increase the accessibility of medical treatment. Conclusion: Urethral injury is a rare injury that requires prompt and careful management to minimize complications and increase the patient’s quality of life. Keywords: Urethral Injury, urethrotomy, urethral stricture.
{"title":"URETHRAL INJURY IN REGIONAL HOSPITAL IN THE BPJS ERA: A CASE REPORT","authors":"Muhammad Omar, Muhammad Taufiq","doi":"10.32421/juri.v30i3.819","DOIUrl":"https://doi.org/10.32421/juri.v30i3.819","url":null,"abstract":"ABSTRACT \u0000Objective: To present a case of urethral injury treated in a male adult. Case(s) Presentation: A 48 year old Asian male patient previously involved in a motor vehicle accident presented to the hospital with a chief complaint of pain and bleeding from the genitalia. On examination, it is revealed bleeding from the urethral meatus, pain in touch, palpable bladder, high riding prostate, and a butterfly-shaped bruising on the perineum. X-ray examination demonstrated soft tissue mass in the right scrotal region. The patient is diagnosed with urethral rupture with urinary retention and then underwent ultrasonography-guided cystostomy and perineal hematoma evacuation. The patient is followed-up 1 month later with a complaint of difficulty in voiding and erectile dysfunction. The patient is then diagnosed with urethral stricture and underwent direct vision urethrotomy. Discussion: Urethral injury is a rare type of injury of genitourinary trauma that may cause long term morbidity such as strictures, incontinence, impotence, and infertility. Urethral injury can be classified into posterior urethral injury which is associated with pelvic fracture and anterior urethral injury which is associated with blunt trauma. The gold standard of radiographic examination in urethral injury is dynamic retrograde urethrography. Prompt diagnosis, staging, and selecting intervention must be done for minimalizing complications. Sequelae may also develop which also affects quality of life. The usage of universal health coverage such as BPJS in In Indonesia can increase the accessibility of medical treatment. Conclusion: Urethral injury is a rare injury that requires prompt and careful management to minimize complications and increase the patient’s quality of life. \u0000Keywords: Urethral Injury, urethrotomy, urethral stricture.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75762395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objective: The purpose of this study is to compare orthotopic neobladder (ONB) and ileal conduit (IC) formation in terms of surgical outcome and complication. Material & Methods: Computerized bibliographic search on different databases related to this study. The PICO criteria method was applied to define research eligibility, per PRISMA recommendations and conducted a systematic review of the literature with meta-analysis. Weighted mean differences with 95 percent confidence intervals were used to compare continuous outcomes. Results: There were 479 publications were discovered and only 6 studies fulfilled the criteria included. The random-effect model's pooled result for urinary leakage complication revealed a significant difference of 1.62 between ONB and IC with higher incidence in neobladder group (95 percent CI, 1.85, 8.69, P = 0.0004) with non-significant heterogeneity (Chi2 = 0.65, df = 3 (P = 0.89), I2 = 0%). Other complications (ileus complication, anastomosis site stenosis, sepsis, urinary infection) showed non-significant difference. Conclusion: Because of the heterogeneity in several aspects of the analyzed papers, further study comparing Orthotopic Neobladder and Ileal conduit in terms of complication following urinary diversion are needed to confirm superiority of ONB or IC as the urinary diversion of choice. Keywords: Orthotopic neobladder, ileal conduit, urinary diversion, radical cystectomy
{"title":"URINARY DIVERSION AFTER RADICAL CYSTECTOMY, ORTHOTOPIC NEOBLADDER VS ILEAL CONDUIT: A SYSTEMATIC REVIEW AND META-ANALYSIS OF POSTOPERATIVE COMPLICATION","authors":"Muhammad Fahri, Gampo Alam","doi":"10.32421/juri.v30i3.841","DOIUrl":"https://doi.org/10.32421/juri.v30i3.841","url":null,"abstract":"ABSTRACT \u0000Objective: The purpose of this study is to compare orthotopic neobladder (ONB) and ileal conduit (IC) formation in terms of surgical outcome and complication. Material & Methods: Computerized bibliographic search on different databases related to this study. The PICO criteria method was applied to define research eligibility, per PRISMA recommendations and conducted a systematic review of the literature with meta-analysis. Weighted mean differences with 95 percent confidence intervals were used to compare continuous outcomes. Results: There were 479 publications were discovered and only 6 studies fulfilled the criteria included. The random-effect model's pooled result for urinary leakage complication revealed a significant difference of 1.62 between ONB and IC with higher incidence in neobladder group (95 percent CI, 1.85, 8.69, P = 0.0004) with non-significant heterogeneity (Chi2 = 0.65, df = 3 (P = 0.89), I2 = 0%). Other complications (ileus complication, anastomosis site stenosis, sepsis, urinary infection) showed non-significant difference. Conclusion: Because of the heterogeneity in several aspects of the analyzed papers, further study comparing Orthotopic Neobladder and Ileal conduit in terms of complication following urinary diversion are needed to confirm superiority of ONB or IC as the urinary diversion of choice. \u0000Keywords: Orthotopic neobladder, ileal conduit, urinary diversion, radical cystectomy","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81066734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryant Agustino Rusli, J. C. Prihadi, Laurentius Rensa, Aswin Pramono
ABSTRACT Objective: The purpose of this study is to find the relation between overweight and obesity with lower urinary tract symptoms due to benign prostatic hyperplasia in pre-elderly. Material & Methods: This analytical study was conducted in a cross sectional manner to 113 respondents. LUTS assessment uses the International Prostate Symptoms Score questionnaire. Measurements for overweight and obesity, this study uses the BMI and waist circumference methods. Fisher's exact test with SPSS v.25 was used for data analysis. Results: Results from data analysis showed that there was no significant relationship between overweight and obesity based on the BMI method on LUTS, p = 0.122. The results also showed a significant relationship between central obesity and LUTS, p = 0.003. Conclusion: Central obesity can be identified as a risk factor for LUTS while overweight and obesity based on the BMI method cannot be considered as a risk factor. These results can be used as education for pre-elderly to reduce the risk of LUTS due to BPH. Keywords: Overweight, obesity, lower urinary tract symptoms, benign prostatic hyperplasia, pre-elderly.
{"title":"RELATIONSHIP BETWEEN OVERWEIGHT AND OBESITY WITH LOWER URINARY TRACT SYMPTOMS (LUTS) DUE TO BENIGN PROSTATIC HYPERLASIA IN PRE-ELDERLY A PRELIMINARY STUDY","authors":"Bryant Agustino Rusli, J. C. Prihadi, Laurentius Rensa, Aswin Pramono","doi":"10.32421/juri.v30i3.778","DOIUrl":"https://doi.org/10.32421/juri.v30i3.778","url":null,"abstract":"ABSTRACT \u0000Objective: The purpose of this study is to find the relation between overweight and obesity with lower urinary tract symptoms due to benign prostatic hyperplasia in pre-elderly. Material & Methods: This analytical study was conducted in a cross sectional manner to 113 respondents. LUTS assessment uses the International Prostate Symptoms Score questionnaire. Measurements for overweight and obesity, this study uses the BMI and waist circumference methods. Fisher's exact test with SPSS v.25 was used for data analysis. Results: Results from data analysis showed that there was no significant relationship between overweight and obesity based on the BMI method on LUTS, p = 0.122. The results also showed a significant relationship between central obesity and LUTS, p = 0.003. Conclusion: Central obesity can be identified as a risk factor for LUTS while overweight and obesity based on the BMI method cannot be considered as a risk factor. These results can be used as education for pre-elderly to reduce the risk of LUTS due to BPH. \u0000Keywords: Overweight, obesity, lower urinary tract symptoms, benign prostatic hyperplasia, pre-elderly.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82012106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santi Ratnalia Parambang, Bacilius Agung Priyosantoso
ABSTRACT Objective: This study aims to knowing the causes and symptoms is very important in determining the management. Case(s) presentation: A 44-year-old man came to the urology clinic with the chief complaint of painful urination after inserting an electric cable 1 meter long and 1 cm in diameter through the urethra 2 days earlier. The patient was then subjected to cystoscopy and removal of the cable using grasping forceps. Discussion: Urinary system foreign bodies can be caused by stimulation when the patient is conscious or under the influence of alcohol, mental disorder, curiosity to medical procedure (iatrogenic). Diagnosis of foreign bodies is based on history, physical examination and supporting examinations in the form of plain abdominal x-rays, ultrasound to CT-Scan. Removal of foreign bodies is adjusted to the type, size and location of foreign bodies in the urinary tract. Conclusion: Recognition of urinary system foreign bodies is very important. The various types of foreign bodies are a challenge for urologists. The selection of an appropriate operative intervention with low complications gives a good prognosis. Keywords: Foreign body, electrical wire, bladder, cystoscopy.
{"title":"URINARY BLADDER FOREIGN BODY: A CASE REPORT","authors":"Santi Ratnalia Parambang, Bacilius Agung Priyosantoso","doi":"10.32421/juri.v30i3.828","DOIUrl":"https://doi.org/10.32421/juri.v30i3.828","url":null,"abstract":"ABSTRACT \u0000Objective: This study aims to knowing the causes and symptoms is very important in determining the management. Case(s) presentation: A 44-year-old man came to the urology clinic with the chief complaint of painful urination after inserting an electric cable 1 meter long and 1 cm in diameter through the urethra 2 days earlier. The patient was then subjected to cystoscopy and removal of the cable using grasping forceps. Discussion: Urinary system foreign bodies can be caused by stimulation when the patient is conscious or under the influence of alcohol, mental disorder, curiosity to medical procedure (iatrogenic). Diagnosis of foreign bodies is based on history, physical examination and supporting examinations in the form of plain abdominal x-rays, ultrasound to CT-Scan. Removal of foreign bodies is adjusted to the type, size and location of foreign bodies in the urinary tract. Conclusion: Recognition of urinary system foreign bodies is very important. The various types of foreign bodies are a challenge for urologists. The selection of an appropriate operative intervention with low complications gives a good prognosis. \u0000Keywords: Foreign body, electrical wire, bladder, cystoscopy.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83821118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Objective: In this study, we want to evaluate the risk factors associated with sexual dysfunction in married women working in health care system. Material & Methods: The sexual function was assessed in the questionnaire using Female Sexual Function Index (FSFI). The analysis was conducted using chi-square test or Fisher Exact Test. Results: All participants who were overweight/obese had highest pain problem (p-value 0.034). Women with diabetes mellitus had higher satisfaction problems (p=0.002, OR 13.13, CI 1.73-99.91). The females who used contraception had significantly lower orgasm problems (p<0.004, OR 0.33, CI 0.15-0.72. Participants who worked as medical staff such as nurse/midwife, pharmacist, radiographer had higher pain problems (71.43%) compared to medical staff (administration staff) (OR 27.47, CI 3.73-202). Conclusion: The BMI (overweight/obesity), diabetes mellitus, the use of contraception, and the medical occupation were the significant risk factors to sexual dysfunction problem in women working in the hospital. Keywords: Female sexual dysfunction, working women, hospital.
摘要目的:本研究旨在探讨在医疗卫生系统工作的已婚女性性功能障碍的相关危险因素。材料与方法:采用女性性功能指数(FSFI)进行问卷调查。采用卡方检验或Fisher精确检验进行分析。结果:所有超重/肥胖的参与者都有最高的疼痛问题(p值0.034)。女性糖尿病患者满意度问题较高(p=0.002, OR 13.13, CI 1.73-99.91)。使用避孕措施的女性性高潮问题显著降低(p<0.004, OR 0.33, CI 0.15-0.72)。与医务人员(行政人员)相比，护士/助产士、药剂师、放射技师等医务人员的疼痛问题(71.43%)更高(OR 27.47, CI 3.73-202)。结论:体重指数(超重/肥胖)、糖尿病、是否采取避孕措施和医疗职业是影响医院女职工性功能障碍的重要危险因素。关键词:女性性功能障碍，职业女性，医院。
{"title":"RISK FACTORS ASSOCIATED WITH FEMALE SEXUAL DYSFUNCTION IN MARRIED WOMEN WORKING IN HEALTH CARE SYSTEM","authors":"Fanny Riana Ridwan, Zulfikar Ali, Kemala Gautami Hidayah, Nazlah Faradila Utari, Ulfa Innayah","doi":"10.32421/juri.v30i3.839","DOIUrl":"https://doi.org/10.32421/juri.v30i3.839","url":null,"abstract":"ABSTRACT \u0000Objective: In this study, we want to evaluate the risk factors associated with sexual dysfunction in married women working in health care system. Material & Methods: The sexual function was assessed in the questionnaire using Female Sexual Function Index (FSFI). The analysis was conducted using chi-square test or Fisher Exact Test. Results: All participants who were overweight/obese had highest pain problem (p-value 0.034). Women with diabetes mellitus had higher satisfaction problems (p=0.002, OR 13.13, CI 1.73-99.91). The females who used contraception had significantly lower orgasm problems (p<0.004, OR 0.33, CI 0.15-0.72. Participants who worked as medical staff such as nurse/midwife, pharmacist, radiographer had higher pain problems (71.43%) compared to medical staff (administration staff) (OR 27.47, CI 3.73-202). Conclusion: The BMI (overweight/obesity), diabetes mellitus, the use of contraception, and the medical occupation were the significant risk factors to sexual dysfunction problem in women working in the hospital. \u0000Keywords: Female sexual dysfunction, working women, hospital. \u0000 ","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84456438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Libri Wira Indra Janu, Septa Surya Wahyudi, K. Sofiana
Objective: To investigate the effect of exposure to chlorpyryphos, carbofuran, and cypermethrin on spermatogenesis in adolescent rat. Material & Methods: This study is an experimental study with a post-test only control group design. In this study, 30 adolescent rats aged 30-45 days were randomly divided into 5 groups. Group I was a normal control or without treatment for 21 days (K0), group II was a solvent control group, namely DMSO 5% which was administered subcutaneously for 21 days (KI), group III was a group that received chlorpyrifos 20 mg/kgBW dissolved with DMSO 5% subcutaneously for 21 days (P1), group IV was the group that received carbofuran 0.2 mg/kgBW dissolved with DMSO 5% subcutaneously for 21 days (P2), group V was the group that received cypermethrin 20 mg/kg. kgBW dissolved with 5% DMSO subcutaneously for 21 days (P3). Ipsilateral testicular orchidectomy was performed on all rats to remove the left testicular organ for preparation with Haematoxylin Eosin staining. The spermatogenesis score was calculated based on the Johnsen score in 5 seminiferous tubule visual fields. Data were analyzed using Kruskal Wallis followed by Mann Mitney test. The difference was considered significant at p<0.05. Results: There was a significant decrease in spermatogenesis scores between P1, P2, and P3 against K0 and K1 (p<0.05). On the other hand, there was no significant difference in the decrease in spermatogenesis scores between P1 and P2, P1 and P3, P2 and P3 and K0 and K1 (p>0.05). Conclusion: Exposure to chlorpyrifos, carbofuran, and cypermethrin had an effect on reducing spermatogenesis scores in adolescent rats.
{"title":"ANALYSIS OF THE EFFECT OF EXPOSURE TO CHLORPYRYPHOS, CARBOFURAN, AND CYPERMETHRIN ON SPERMATOGENESIS IN ADOLESCENT RAT","authors":"Libri Wira Indra Janu, Septa Surya Wahyudi, K. Sofiana","doi":"10.32421/juri.v30i2.803","DOIUrl":"https://doi.org/10.32421/juri.v30i2.803","url":null,"abstract":"Objective: To investigate the effect of exposure to chlorpyryphos, carbofuran, and cypermethrin on spermatogenesis in adolescent rat. Material & Methods: This study is an experimental study with a post-test only control group design. In this study, 30 adolescent rats aged 30-45 days were randomly divided into 5 groups. Group I was a normal control or without treatment for 21 days (K0), group II was a solvent control group, namely DMSO 5% which was administered subcutaneously for 21 days (KI), group III was a group that received chlorpyrifos 20 mg/kgBW dissolved with DMSO 5% subcutaneously for 21 days (P1), group IV was the group that received carbofuran 0.2 mg/kgBW dissolved with DMSO 5% subcutaneously for 21 days (P2), group V was the group that received cypermethrin 20 mg/kg. kgBW dissolved with 5% DMSO subcutaneously for 21 days (P3). Ipsilateral testicular orchidectomy was performed on all rats to remove the left testicular organ for preparation with Haematoxylin Eosin staining. The spermatogenesis score was calculated based on the Johnsen score in 5 seminiferous tubule visual fields. Data were analyzed using Kruskal Wallis followed by Mann Mitney test. The difference was considered significant at p<0.05. Results: There was a significant decrease in spermatogenesis scores between P1, P2, and P3 against K0 and K1 (p<0.05). On the other hand, there was no significant difference in the decrease in spermatogenesis scores between P1 and P2, P1 and P3, P2 and P3 and K0 and K1 (p>0.05). Conclusion: Exposure to chlorpyrifos, carbofuran, and cypermethrin had an effect on reducing spermatogenesis scores in adolescent rats.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"49 12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79766799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saga Aditya Hutama, B. Daryanto, Medianto, Atma Gunawan
Objective: This study aims to analyze the factors associated such as hemodialysis periods, age, and smoking with ED severity in CKD patients undergoing routine hemodialysis. Material & Methods: A single-center, cross-sectional study was conducted involving a total 101 patients who were on routine hemodialysis who diagnosed with CKD and experienced complaint in sexual function were included. The severity of ED classified based on the International Index of Erectile Function (IIEF-5). The analysis was carried out descriptively and analytically using the ordinal regression method. Results: Hemodialysis duration (p = 0.044) were significantly related to severity of erectile dysfunction in patient with CKD and on routine hemodialysis. Meanwhile, although both older age (p =0.307) and smoking (p = 0.283) showed a positive estimate, they were not statistically significant. Conclusion: The study indicate that prevalence of ED observed in CKD patient with routine hemodialysis remain high. Several factors significantly contribute in ED severity such as shorter hemodialysis duration.
{"title":"ANALYSIS OF HEMODIALYSIS PERIODS, AGE, AND SMOKING TOWARDS THE SEVERITY OF ERECTILE DYSFUNCTION IN PATIENTS WITH CHRONIC RENAL FAILURE ON ROUTINE HEMODIALYSIS","authors":"Saga Aditya Hutama, B. Daryanto, Medianto, Atma Gunawan","doi":"10.32421/juri.v30i2.852","DOIUrl":"https://doi.org/10.32421/juri.v30i2.852","url":null,"abstract":"Objective: This study aims to analyze the factors associated such as hemodialysis periods, age, and smoking with ED severity in CKD patients undergoing routine hemodialysis. Material & Methods: A single-center, cross-sectional study was conducted involving a total 101 patients who were on routine hemodialysis who diagnosed with CKD and experienced complaint in sexual function were included. The severity of ED classified based on the International Index of Erectile Function (IIEF-5). The analysis was carried out descriptively and analytically using the ordinal regression method. Results: Hemodialysis duration (p = 0.044) were significantly related to severity of erectile dysfunction in patient with CKD and on routine hemodialysis. Meanwhile, although both older age (p =0.307) and smoking (p = 0.283) showed a positive estimate, they were not statistically significant. Conclusion: The study indicate that prevalence of ED observed in CKD patient with routine hemodialysis remain high. Several factors significantly contribute in ED severity such as shorter hemodialysis duration.","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86396059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhamad Abi Salman Aziz, Achmad Fayyad Mas`udi, A. S. Rahaju, L. Dewanti
Objective: This literature review aims to explain the role of nephrectomy in the treatment of localized RCC and its effects on postoperative renal function, as well as the role of the new baseline glomerular filtration rate (NBGFR) estimation method in the determination of the RCC method. Material & Methods: Articles were obtained through online searches using Pubmed, ScienceDirect, Web of Science, and Wiley Online Library using keywords NBGFR, renal function, nephrectomy, or localized renal cell carcinoma. Results: The development of several diagnostic factors as well as operative factors has made partial nephrectomy (PN) replace radical nephrectomy (RN) which for decades has been the main therapy in localized RCC. Postoperative determination of renal function is a crucial factor in the selection of therapies and several methods of determining NBGFR have been proposed in several previous studies. Conclusion: The NBGFR measurement method can be an accurate guide in the determination of nephrectomy methods in the treatment of localized RCC while use of computer software can help improve accuracy in the implementation of radical nephrectomy in RCC.
目的:本文献综述旨在解释肾切除术在局部RCC治疗中的作用及其对术后肾功能的影响，以及新的基线肾小球滤过率(NBGFR)估算方法在确定RCC方法中的作用。材料与方法:文章通过Pubmed、ScienceDirect、Web of Science和Wiley online Library在线检索获得，检索关键词为NBGFR、肾功能、肾切除术或局部肾细胞癌。结果:随着多种诊断因素和手术因素的发展，部分肾切除术(PN)已经取代了根治性肾切除术(RN)，根治性肾切除术几十年来一直是局部肾细胞癌的主要治疗方法。术后肾功能的测定是选择治疗方法的关键因素，在之前的一些研究中提出了几种测定NBGFR的方法。结论:NBGFR测量法可准确指导局部肾细胞癌治疗中肾切除术方法的确定，计算机软件的应用可提高肾细胞癌根治性切除术实施的准确性。
{"title":"NEW BASELINE GLOMERULAR FILTRATION RATE ESTIMATION AS A GUIDANCE FOR NEPHRECTOMY STRATEGY IN LOCALIZED RENAL CELL CARCINOMA","authors":"Muhamad Abi Salman Aziz, Achmad Fayyad Mas`udi, A. S. Rahaju, L. Dewanti","doi":"10.32421/juri.v30i2.843","DOIUrl":"https://doi.org/10.32421/juri.v30i2.843","url":null,"abstract":"Objective: This literature review aims to explain the role of nephrectomy in the treatment of localized RCC and its effects on postoperative renal function, as well as the role of the new baseline glomerular filtration rate (NBGFR) estimation method in the determination of the RCC method. Material & Methods: Articles were obtained through online searches using Pubmed, ScienceDirect, Web of Science, and Wiley Online Library using keywords NBGFR, renal function, nephrectomy, or localized renal cell carcinoma. Results: The development of several diagnostic factors as well as operative factors has made partial nephrectomy (PN) replace radical nephrectomy (RN) which for decades has been the main therapy in localized RCC. Postoperative determination of renal function is a crucial factor in the selection of therapies and several methods of determining NBGFR have been proposed in several previous studies. Conclusion: The NBGFR measurement method can be an accurate guide in the determination of nephrectomy methods in the treatment of localized RCC while use of computer software can help improve accuracy in the implementation of radical nephrectomy in RCC. \u0000 ","PeriodicalId":13565,"journal":{"name":"Indonesian Journal of Urology","volume":"139 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83279023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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