Integrative Medicine Research最新文献_第6页

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100976

Lu Ding , Cui Li , Peiming Zhang , Chen Chen , Jie Zhan , Jinchun Zeng , Liming Lu

Background

An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work.

Methods

Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms.

Results

Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], P = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], P = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], P = 0.005) with high heterogeneity.

Conclusions

Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials.

Study registration

The protocol of this review has been registered at PROSPERO (CRD42022335505).

背景近年来，越来越多的临床证据表明针灸治疗阿片类药物长期戒断综合征（POAS）。本研究的目的是评估针灸治疗POAS的疗效证据。临床和科研工作。方法检索4个英文数据库（PubMed、Medline、Embase、Cochrane Libraries）和3个中文数据库（CNKI、WanFang和VIP Libraries。随机临床试验（RCT）评估了针灸和针灸相关疗法预防或治疗POAS的效果。根据预设的表格格式对数据进行独立筛选和提取。使用Cochrane协作中的偏倚风险工具评估随机对照试验的质量。主要结果是阿片类药物戒断量表。次要结果是抑郁，评估长期症状的焦虑。上述量表上的分数与症状的严重程度成正比。结果28项试验符合纳入标准，为荟萃分析提供了数据。由于存在各种偏见，总共只有3项研究（11%）被判定为总体低风险。与假针灸相比，针灸相关治疗在改善长期戒断症状评分方面显示出统计学差异（5项研究，标准平均差（SMD），-1.85，95%CI[3.21，-0.50]，P=0.007），西药（7项研究，SMD，-0.72，95%CI[1.22，-0.21]，P=0.005）和无治疗（3项研究，SMT，-2.26，95%CI[3.82，-0.69]，P=0.0005）具有高度异质性。结论针刺对缓解POAS患者的长期戒断症状可能是安全有效的。然而，我们的审查结果应谨慎解读，因为纳入的试验存在较高的偏倚风险。研究注册本次审查的方案已在PROSPERO注册（CRD42022335505）。

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引用次数: 0

Efficacy and safety of herbal medicine (Binafuxi granules) for the common cold with fever: A multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial 宾纳福喜颗粒治疗普通感冒发热的疗效和安全性:一项多中心、随机、双盲、安慰剂对照的II期临床试验

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100956

Xuemei Liu , Jie Min , Bin She , Yan Chen , Jun Li , Lei Huang , Ju Chen , Ai Luo , Mei Yang , Ting Li , Yanqing Wu , Daohong Chen , Hongli Zhong , Wei Liu , Bing Mao , Hongli Jiang

Background

Binafuxi granules are a traditional Uighur medicine (TUM) for treating the common cold with fever. However, high-quality clinical studies supporting its efficacy and safety are lacking.

Methods

In this multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial, patients with common cold and fever were randomly assigned to a high-dose group, low-dose group, and placebo group in a 1:1:1 ratio. Outcomes were time to fever relief, time to fever clearance, proportion of afebrile patients, time to symptom disappearance, rate of symptom disappearance, effective rate, emergency drug usage and safety assessment.

Results

A total of 235 patients were recruited. Of these, 234 were included in the full analysis set (FAS), and 217 were included in the per-protocol set (PPS). In the FAS analysis, the median time to fever relief was 6.00 h, 5.54 h and 10.65 h (P = 0.31) in the high-dose group, low-dose group and placebo group, respectively. The median time to fever clearance was 18.29 h, 20.08 h and 25.00 h (P = 0.0018), respectively, and the proportion of afebrile patients was 92.4%, 89.7% and 71.4% (P = 0.0002), respectively. There was a significant difference in the disappearance time and disappearance rate of all symptoms and of individual symptoms. No serious adverse events were found.

Conclusions

Binafuxi granules can dose-dependently shorten the fever course and improve clinical symptoms in patients suffering from the common cold with fever.

Trial Registration

This trial was registered at Chinese Clinical Trial Registry (ChiCTR-IIR-17013379).

背景必那福喜颗粒是一种治疗普通感冒伴发热的维吾尔族传统药物。然而，缺乏支持其疗效和安全性的高质量临床研究。方法在这项多中心、随机、双盲、安慰剂对照的II期临床试验中，将普通感冒和发烧患者按1:1:1的比例随机分为高剂量组、低剂量组和安慰剂组。结果包括退烧时间、退热时间、无热患者比例、症状消失时间、症状消失率、有效率、紧急用药和安全性评估。结果共招募235名患者。其中，234项纳入完整分析集（FAS），217项纳入按方案集（PPS）。在FAS分析中，高剂量组、低剂量组和安慰剂组的中位退烧时间分别为6.00小时、5.54小时和10.65小时（P=0.31）。发热消退的中位时间分别为18.29小时、20.08小时和25.00小时（P=0.0018），无热患者的比例分别为92.4%、89.7%和71.4%（P=0.0002）。所有症状和个别症状的消失时间和消失率存在显著差异。未发现严重不良事件。结论必复喜颗粒能剂量依赖性地缩短普通感冒伴发热患者的发热病程，改善临床症状。试验注册本试验在中国临床试验注册中心（ChiCTR-IIR-17013379）注册。

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引用次数: 0

AI Chat bot - ChatGPT-4: A new opportunity and challenges in complementary and alternative medicine AI聊天机器人-ChatGPT-4：补充和替代医学的新机遇和挑战

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100977

Tae-Hun Kim , Jung Won Kang , Myeong Soo Lee

引用次数: 0

Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial 埋线针刺可改善胃食管反流病患者的症状缓解:一项随机对照试验

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100971

Dieu-Thuong Thi Trinh , An Hoa Tran , Minh-Man Pham Bui , Nguyen Lam Vuong

Background

Various traditional medicine treatments have been investigated to treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage that patients need to undergo the procedure infrequently; however, its efficacy is unclear. This study evaluated the efficacy of TEA in treating GERD.

Methods

A randomized controlled trial was conducted with 66 participants with GERD: 33 received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. The safety outcome was adverse events (AEs).

Results

After four weeks of treatment, the TEA+PPI group significantly reduced the GerdQ score (mean difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and increased the rate of heartburn and regurgitation resolution compared to PPI (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, which were mild local complications at the acupoints.

Conclusion

TEA combined with PPI is more effective than PPI alone in treating GERD. Further studies with longer follow-ups are required to confirm these findings.

Clinical trials registration information

This study was registered at ClinicalTrials.gov, NCT05353933.

背景研究了多种传统药物治疗胃食管反流病的方法。其中，线埋针灸（TEA）的优点是患者不需要经常进行手术；然而，其疗效尚不清楚。本研究评估了TEA治疗GERD的疗效。方法对66名GERD患者进行了随机对照试验：33人接受两次TEA+标准治疗（质子泵抑制剂[PPI]）（TEA+PPI组），33人单独接受PPI（PPI组）。主要结果包括GerdQ评分、烧心和反流消退。次要结果是抗酸剂需求、胃食管反流病症状频率量表（FSSG）评分和胃食管反流病健康相关生活质量（GERD-HRQL）评分。安全性结果为不良事件（AE）。结果治疗4周后，TEA+PPI组显著降低了GerdQ评分（平均差[MD]和95%置信区间[CI]：-1.8[-2.4，-1.1]），并与PPI相比增加了烧心率和反流消退率（分别为54.5%和9.1%）。与PPI相比，TEA+PPI组还显著减少了抗酸包的使用次数（MD[95%-CI]:-9.4[-12.1，-6.7]）、FSSG评分（MD[90%-CI]:-9.4[-11.0，-7.8]）和GERD-HRQL评分（MD-95%-CI]:-5.6[-7.7，-3.5]）。5例患者出现AE，为轻微的穴位局部并发症。结论TEA联合PPI治疗GERD疗效优于单纯PPI。需要进一步的研究和更长的随访来证实这些发现。临床试验注册信息本研究注册于ClinicalTrials.gov，NCT05353933。

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引用次数: 1

Clinical effectiveness of decoction form of herbal medicine in primary care treatment of allergic rhinitis: A retrospective cohort study 中药汤剂在初级保健治疗变应性鼻炎中的临床疗效:回顾性队列研究

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100973

Mi Ju Son , Sungha Kim , Young-Eun Kim , Bo-Young Kim , Chang-Sub Yeum , Jong Cheol Lee , Jae Hoon Cha , Soonsik Kang , Ching Hao Chang , Seokho Son

Background

The decoction form of herbal medicine (D-HM) is mainly prescribed to patients with allergic rhinitis (AR) in Korean Medicine (KM) clinics in the Republic of Korea; however, it is difficult to conduct clinical trials of D-HM due to regulatory issues. This study investigated the clinical safety and effectiveness of D-HM combination therapy for the treatment of AR by analyzing the AR outpatient data from 17 KM clinics.

Methods

This retrospective cohort study included patients who visited KM clinics for AR treatment from January 1, 2021, to March 31, 2022. Cases were collated using structured case report forms and divided into the D-HM with KM usual care group (D-HM group) and the KM usual care group (UC group). Since D-HM therapy could not be randomly assigned to the study population, we used optimal propensity score (PS) matching to investigate the effectiveness and safety of D-HM combination therapy in the treatment of AR.

Results

Data from 228 patients were collected. After PS matching, 144 patients were finally analyzed. The total nasal symptom score (TNSS) and mini-rhinoconjunctivitis quality of life questionnaire (mini-RQLQ) were significantly improved in the D-HM group compared with those in the UC group (TNSS: p=0.02; mini-RQLQ: p=0.04). Four patients in the D-HM group experienced minor adverse events that were mild and resolved within 15 days.

Conclusions

D-HM combination therapy may be beneficial in the management of symptoms and rhinitis-associated quality of life and potentially useful in clinical practice. However, randomized placebo-controlled clinical trials are required to confirm their effectiveness.

Study registration

This study has been registered at Clinical Research Information Service (KCT0007242).

背景韩国中医诊所主要为过敏性鼻炎（AR）患者开中药饮片（D-HM）；然而，由于监管问题，D-HM的临床试验很难进行。本研究通过分析17家KM诊所的AR门诊数据，探讨了D-HM联合治疗AR的临床安全性和有效性。方法这项回顾性队列研究包括2021年1月1日至2022年3月31日期间前往KM诊所接受AR治疗的患者。使用结构化病例报告表对病例进行整理，并将其分为D-HM和KM常规护理组（D-HM组）和KM常规治疗组（UC组）。由于D-HM治疗不能随机分配给研究人群，我们使用最佳倾向评分（PS）匹配来研究D-HM联合治疗AR的有效性和安全性。结果收集了228名患者的数据。在PS匹配后，最终对144名患者进行了分析。与UC组相比，D-HM组的鼻腔症状总分（TNSS）和迷你鼻结膜炎生活质量问卷（迷你RQLQ）显著改善（TNSS:p=0.02；迷你RQLQ:p=0.04）。D-HM组有4名患者出现轻微不良事件，症状轻微，在15天内缓解。结论sD-HM联合治疗可能有助于控制症状和鼻炎相关的生活质量，并有可能在临床实践中发挥作用。然而，需要进行随机安慰剂对照临床试验来确认其有效性。研究注册本研究已在临床研究信息服务中心（KCT0007242）注册。

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引用次数: 0

Economic evaluation of acupuncture as an adjunctive treatment with usual care for mild-to-moderate knee osteoarthritis: A Markov model-based analysis 针灸作为常规护理辅助治疗轻中度膝骨关节炎的经济评价:基于马尔可夫模型的分析

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100982

Eunhye Hyun , Byung-Cheul Shin , NamKwen Kim , Byungmook Lim

Background

Collaborative care (CC), in which acupuncture is combined with usual care (UC), improves clinical outcomes and increases costs in knee osteoarthritis (KOA). We evaluated the economic feasibility of CC for Korean female patients with mild-to-moderate KOA by using a cost-effectiveness approach.

Methods

Two alternatives for KOA (1. UC as a comparator; and 2. CC as an intervention) were defined based on clinical guidelines, official Korean statistics, and expert validation. Each alternative was simulated in a Markov model every 6 months for 10 years. Estimates of costs, utilities, and transition probabilities were obtained from official statistics and previous studies. The effectiveness of CC was synthesized from randomized controlled trials. A base-case analysis of a limited societal perspective, univariate sensitivity analysis, and probability sensitivity analysis were performed. An annual discount rate of 4.5% and threshold of 20,000 United States dollar per Quality-adjusted life year (USD/QALY) were applied.

Results

Every incremental cost-effectiveness ratio (ICER) of CC calculated from the analyses was sub-threshold. In the base-case analysis, with a limited societal perspective, the ICER was 11,085 USD/QALY. The ICERs from the univariate sensitivity analyses were -2,577–16,748 USD/QALY. The average ICER in the probability sensitivity analysis was 12,412 USD/QALY. When the threshold surpassed 8,000 USD/QALY, the cost-effectiveness of CC exceeded 50%. The probability was 70.27% when the threshold was 20,000 USD/QALY.

Conclusions

CC for Korean female patients with mild-to-moderate KOA was generally cost-effective. Considering the limitations of the evidence, we propose a re-evaluation using further clinical studies in the future.

背景协同护理（CC），即针灸与常规护理（UC）相结合，可以改善膝骨关节炎（KOA）的临床疗效并增加成本。我们使用成本效益方法评估了CC治疗轻度至中度KOA的韩国女性患者的经济可行性。方法KOA的两种替代方案（1。UC作为比较器；和2。CC作为一种干预措施）的定义基于临床指南、韩国官方统计数据和专家验证。在马尔可夫模型中每6个月对每个备选方案进行10年的模拟。对成本、公用事业和过渡概率的估计是从官方统计数据和以前的研究中获得的。CC的有效性是从随机对照试验中综合得出的。进行了有限社会视角的基本案例分析、单变量敏感性分析和概率敏感性分析。采用4.5%的年折扣率和20000美元/质量调整寿命年（美元/QALY）的门槛。结果通过分析计算出的CC的每个增量成本效益比（ICER）均在阈值以下。在基本案例分析中，在有限的社会视角下，ICER为11085美元/年。单变量敏感性分析得出的ICER为-2577–16748美元/年。概率敏感性分析中的平均ICER为12412美元/QALY。当阈值超过8000美元/QALY时，CC的成本效益超过50%。当阈值为20000美元/QALY时，概率为70.27%。结论CC治疗轻度至中度KOA的韩国女性患者通常具有成本效益。考虑到证据的局限性，我们建议在未来使用进一步的临床研究进行重新评估。

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引用次数: 0

The impact of yoga on stress, metabolic parameters, and cognition of Indian adolescents: A cluster randomized controlled trial 瑜伽对印度青少年压力、代谢参数和认知的影响:一项随机对照试验

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100979

Harish Ranjani , Narayanaswamy Jagannathan , Tina Rawal , Radhakrishnan Vinothkumar , Nikhil Tandon , Jayaram Vidyulatha , Viswanathan Mohan , Yashdeep Gupta , Ranjit Mohan Anjana

Background

This project aimed to assess the impact of yoga on stress, metabolic parameters and cognition (attention & concentration) in adolescents, aged 13–15 years from public and private schools in two cities (Chennai and New Delhi) in India.

Methods

The study recruited 2000 adolescents from 24 schools in a cluster randomized controlled trial design. The yoga group participants underwent 17 yoga sessions, which included: pranayama, basic asanas, meditation and relaxation exercises. Yoga sessions, were held in the school premises once a week. A total of five awareness talks on healthy lifestyle were delivered once a month to the education group. ADOlescence Stress Scale (ADOSS), salivary cortisol, metabolic and clinical parameters and Letter Cancellation Test (LCT) score were measured at baseline and post-intervention (5–6 months).

Results

The yoga group showed statistically significant differences in the mean ADOSS score, metabolic parameters, salivary cortisol, and LCT scores compared to the education group. In the intention- to- treat analysis, a significant reduction [5.11, 95% CI (4.78, 5.36), p = 0.001] in ADOSS score was seen in the yoga group compared to education.

Conclusion

Implementation of a 17-week standardized yoga program at the school level significantly decreased stress, improved attention and concentration, metabolic and clinical parameters in Indian adolescents.

Trial registration

This trial was registered at Clinical Trials Registry, India (CTRI/2017/08/009203).

背景该项目旨在评估瑜伽对印度两个城市（金奈和新德里）公立和私立学校13-15岁青少年的压力、代谢参数和认知（注意力和注意力）的影响。方法采用整群随机对照试验设计，从24所学校招募2000名青少年。瑜伽组参与者接受了17次瑜伽训练，其中包括：调息、基本体式、冥想和放松练习。瑜伽课程，每周在学校举行一次。每月向教育小组进行一次关于健康生活方式的宣传讲座，共五次。在基线和干预后（5-6个月）测量青春期应激量表（ADOSS）、唾液皮质醇、代谢和临床参数以及字母消除测试（LCT）评分。结果与教育组相比，瑜伽组在ADOSS平均得分、代谢参数、唾液皮质醇和LCT得分方面存在统计学显著差异。在意向治疗分析中，与教育相比，瑜伽组的ADOSS评分显著降低[5.11，95%CI（4.78，5.36），p=0.001]。结论在学校实施为期17周的标准化瑜伽项目显著降低了印度青少年的压力，提高了他们的注意力和专注力、代谢和临床参数。试验注册本试验在印度临床试验注册中心注册（CTRI/2017/08/009203）。

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引用次数: 0

The association between acupuncture therapy and the risk of reduced pressure ulcers in dementia patients: A retrospective matched cohort study 针灸治疗与痴呆患者减压性溃疡风险之间的关系:一项回顾性匹配队列研究

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100981

Chia-Yu Huang , Mei-Yao Wu , Ming-Cheng Huang , Teng-Shun Yu , Hung-Rong Yen

Background

The pressure ulcer is a complication developed from dementia. The aim of this study is to study the association between the development of pressure ulcers and the use of acupuncture therapy in patients with dementia.

Methods

We performed a retrospective 1:1 propensity score-matched cohort study to investigate the association between acupuncture therapy and the risk of pressure ulcers in patients with dementia.

Results

A total of 8,994 patients were identified, 237 patients in the acupuncture cohort and 362 patients in the no-acupuncture cohort developed pressure ulcers. A reduced cumulative incidence of pressure ulcers was observed in the acupuncture cohort (P<0.001). The association between acupuncture and reducing the incidence of pressure ulcers was not affected by sex, age, residence, income, or comorbidities. The variables of etiologies to cause dementia did not change the final result. In the subgroups analyses, the patients without medication for dementia control had a significantly lower rate of pressure ulcers development when they had accepted acupuncture therapy (log-rank test, P<0.001).

Conclusion

Our results revealed the association between acupuncture therapy and a reduced incidence of pressure ulcer development in patients with dementia. This finding offers important ideas for further research.

背景压疮是由痴呆引起的并发症。本研究的目的是研究痴呆患者压疮的发展与针灸治疗之间的关系。方法我们进行了一项回顾性的1:1倾向评分匹配队列研究，以调查针灸治疗与痴呆患者压疮风险之间的关系。结果共发现8994名患者，237名针灸组患者和362名非针灸组患者出现压疮。在针灸队列中观察到压疮的累积发病率降低（P<；0.001）。针灸与降低压疮发病率之间的相关性不受性别、年龄、居住地、收入或合并症的影响。导致痴呆的病因变量并没有改变最终结果。在亚组分析中，未服用药物控制痴呆症的患者在接受针灸治疗时，压疮发生率显著降低（log-rank检验，P<；0.001）。这一发现为进一步研究提供了重要的思路。

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引用次数: 0

Three aspects of acupuncture-related adverse events: Issues around the reporting of acupuncture-related adverse events 针灸相关不良事件的三个方面:围绕针灸相关不良事件报告的问题

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100980

Tae-Hun Kim , Stephen Birch , Terje Alraek , Myeong Soo Lee

引用次数: 0

Complementary, alternative, and integrative medicine-specific COVID-19 misinformation on social media: A scoping review 社交媒体上针对COVID-19的补充、替代和综合医学错误信息:范围审查

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100975

Jeremy Y. Ng , Shawn Liu , Ishana Maini , Will Pereira , Holger Cramer , David Moher

Background

The sharing of health-related information has become increasingly popular on social media. Unregulated information sharing has led to the spread of misinformation, especially regarding complementary, alternative, and integrative medicine (CAIM). This scoping review synthesized evidence surrounding the spread of CAIM-related misinformation on social media during the COVID-19 pandemic.

Methods

This review was informed by a modified version of the Arksey and O'Malley scoping review framework. AMED, EMBASE, PsycINFO and MEDLINE databases were searched systematically from inception to January 2022. Eligible articles explored COVID-19 misinformation on social media and contained sufficient information on CAIM therapies. Common themes were identified using an inductive thematic analysis approach.

Results

Twenty-eight articles were included. The following themes were synthesized: 1) misinformation prompts unsafe and harmful behaviours, 2) misinformation can be separated into different categories, 3) individuals are capable of identifying and refuting CAIM misinformation, and 4) studies argue governments and social media companies have a responsibility to resolve the spread of COVID-19 misinformation.

Conclusions

Misinformation can spread more easily when shared on social media. Our review suggests that misinformation about COVID-19 related to CAIM that is disseminated online contributes to unsafe health behaviours, however, this may be remedied via public education initiatives and stricter media guidelines. The results of this scoping review are crucial to understanding the behavioural impacts of the spread of COVID-19 misinformation about CAIM therapies, and can inform the development of public health policies to mitigate these issues.

背景与健康相关的信息共享在社交媒体上越来越受欢迎。不受管制的信息共享导致了错误信息的传播，尤其是关于补充医学、替代医学和综合医学（CAIM）的错误信息。这项范围审查综合了新冠肺炎大流行期间社交媒体上CAIM相关错误信息传播的证据。方法本次审查由Arksey和O'Malley范围界定审查框架的修改版本提供信息。AMED、EMBASE、PsycINFO和MEDLINE数据库从成立到2022年1月进行了系统搜索。符合条件的文章探讨了社交媒体上的新冠肺炎错误信息，并包含了关于CAIM疗法的足够信息。采用归纳专题分析方法确定了共同主题。结果共收录文章28篇。综合了以下主题：1）错误信息引发不安全和有害行为，2）错误信息可以分为不同类别，3）个人能够识别和反驳CAIM错误信息，4）研究表明，政府和社交媒体公司有责任解决新冠肺炎错误信息的传播。结论在社交媒体上分享虚假信息更容易传播。我们的审查表明，网上传播的与CAIM相关的关于新冠肺炎的错误信息会导致不安全的健康行为，然而，这可以通过公共教育举措和更严格的媒体指南来纠正。这一范围审查的结果对于理解新冠肺炎关于CAIM疗法的错误信息传播的行为影响至关重要，并可以为制定缓解这些问题的公共卫生政策提供信息。

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