Integrative Medicine Research最新文献_第6页

Acupuncture for patients with Cancer in a Japanese palliative care team: A prospective case series study 针灸治疗癌症患者在日本姑息治疗团队：前瞻性病例系列研究

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-08-05 DOI: 10.1016/j.imr.2025.101212

Shoko Masuyama , Hitoshi Yamashita , Tamami Amino , Ryouko Kawamoto , Ryota Tsuji , Hiromoto Nakanishi , Hiroshi Yoshida

Background

The joint guidelines of the Society for Integrative Oncology and the American Society of Clinical Oncology recommend acupuncture for pain symptoms in some patients with cancer. This study assessed whether adding acupuncture to usual palliative care alleviates the subjective symptoms of hospitalized patients with cancer in Japan, at least in the short term.

Methods

Between 2015 and 2019, we conducted a prospective case series study at a regional core hospital in Osaka. Acupuncture was included in the usual care of patients with cancer. The primary outcome was immediate changes in each patient’s subjective symptoms measured by a 10 cm visual analog scale (VAS). A 20 % reduction in VAS was set as the minimal clinically important difference (MCID).

Results

A total of 83 cancer patients (mean age: 66.1) were treated with acupuncture. A significant reduction was observed in the VAS scores for pain, edema, nausea, neck/shoulder/back stiffness, and breathlessness during at least one treatment session. The percentage of patients that improved beyond the MCID was as follows: 67 % for pain, 75 % for edema, 60 % for paresthesia, 80 % for nausea, 88 % for stiffness, 38 % for malaise, and 83 % for breathlessness, based on the maximum improvement recorded per session.

Conclusion

Japanese-style acupuncture, with relatively finer needles and gentler stimulation, has shown promise as a palliative treatment for patients with cancer, potentially offering temporary relief from pain, edema, nausea, stiffness, and breathlessness. Based on our findings, a pragmatic randomized controlled trial with an appropriate control group is recommended.

背景：综合肿瘤学会和美国临床肿瘤学会的联合指南推荐针灸治疗一些癌症患者的疼痛症状。本研究评估在常规姑息治疗中加入针灸是否至少在短期内缓解了日本住院癌症患者的主观症状。方法2015 - 2019年，在大阪某区域核心医院开展前瞻性病例系列研究。针灸被包括在癌症患者的常规护理中。主要结果是通过10cm视觉模拟量表（VAS）测量每位患者主观症状的立即变化。VAS评分降低20%作为最小临床重要差异（minimum clinical important difference， MCID）。结果共治疗83例肿瘤患者，平均年龄66.1岁。在至少一次治疗期间，疼痛、水肿、恶心、颈/肩/背部僵硬和呼吸困难的VAS评分显著降低。超过MCID改善的患者比例如下：67%为疼痛，75%为水肿，60%为感觉异常，80%为恶心，88%为僵硬，38%为不适，83%为呼吸困难，基于每次记录的最大改善。结论：日式针灸针刺相对细，刺激温和，有望作为癌症患者的姑息治疗，可能暂时缓解疼痛、水肿、恶心、僵硬和呼吸困难。根据我们的研究结果，建议进行一项实用的随机对照试验，并选择合适的对照组。

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引用次数: 0

A cost-utility analysis of pharmacopuncture versus physiotherapy for chronic low back pain: A multicenter, pragmatic randomized controlled trial 药物穿刺与物理疗法治疗慢性腰痛的成本-效用分析：一项多中心、实用的随机对照试验

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-08-05 DOI: 10.1016/j.imr.2025.101210

Ye-Seul Lee , Soo Jin Kim , Kyung Sun Park , Yoon Jae Lee , Changsop Yang , Chang-Hyun Han , In-Hyuk Ha

Background

Chronic low back pain (cLBP) is a significant global health issue, contributing to disability and economic strain. Nonpharmacological treatments, such as acupuncture and integrative approaches like pharmacopuncture (PPT), have shown potential in alleviating the burden of cLBP. This study aimed to evaluate the cost-effectiveness of PPT compared to physical therapy (PT) for managing cLBP from both healthcare system and societal perspectives.

Methods

A multicenter, two-arm randomized controlled trial was conducted, involving 100 patients with cLBP. Patients were randomized into either the PPT group or the PT group, receiving 10 treatment sessions over five weeks. Utility was measured using the EuroQol 5-Dimension 5-Level scale (EQ-5D-5L) to calculate quality-adjusted life years (QALYs), and costs were evaluated from healthcare and societal perspectives, including medical costs and productivity loss. Productivity loss was assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire. Incremental cost-effectiveness ratios (ICERs) were calculated by dividing the differences in costs by the differences in QALYs between the two groups. Bootstrapping and sensitivity analyses were performed to assess robustness.

Results

PPT was more cost-effective than PT, particularly from a societal perspective where it demonstrated lower overall costs and improved QALY. From a healthcare system perspective, the ICER of PPT was 16,575 USD per QALY, indicating cost-effectiveness. Sensitivity analyses confirmed the robustness of these findings.

Conclusion

This study highlights PPT as a potentially cost-effective alternative to conventional PT for cLBP, though further research with larger sample sizes and extended follow-up is recommended to validate these results.

Trial registration

ClinicalTrials.gov (NCT04833309), Clinical Research Information Service (KCT0006088).

慢性腰痛（cLBP）是一个重要的全球健康问题，导致残疾和经济紧张。非药物治疗，如针灸和药物穿刺（PPT）等综合方法，已显示出减轻cLBP负担的潜力。本研究旨在从医疗保健系统和社会角度评估PPT与物理治疗（PT）相比治疗cLBP的成本效益。方法采用多中心、两组随机对照试验，纳入100例cLBP患者。患者被随机分为PPT组和PT组，在5周内接受10次治疗。使用EuroQol 5维5级量表（EQ-5D-5L）测量效用以计算质量调整生命年（QALYs），并从医疗保健和社会角度评估成本，包括医疗成本和生产力损失。使用工作效率和活动障碍（WPAI）问卷评估生产力损失。增量成本-效果比（ICERs）通过将成本差异除以两组间质量质量年的差异来计算。采用自举和敏感性分析来评估稳健性。结果sppt比PT更具成本效益，特别是从社会角度来看，它显示出更低的总成本和改善的质量。从医疗保健系统的角度来看，PPT的ICER为16,575美元/ QALY，表明成本效益。敏感性分析证实了这些发现的稳健性。结论本研究强调PPT是治疗cLBP的一种具有潜在成本效益的替代方法，但建议进一步研究更大的样本量和延长随访时间来验证这些结果。临床试验注册：clinicaltrials .gov (NCT04833309)，临床研究信息服务（KCT0006088）。

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引用次数: 0

Effectiveness and safety of herbal medicine on treatment of dysmenorrhea: An analysis of a multicenter, prospective observational study 中药治疗痛经的有效性和安全性：一项多中心前瞻性观察性研究分析

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-31 DOI: 10.1016/j.imr.2025.101209

Se-In Cho , Hyo-Jeong Jung , Minjung Park , Dong-Il Kim

Background

This study aimed to evaluate the effectiveness and safety of individually prescribed decoction herbal medicine for the treatment of dysmenorrhea. Herbal decoction was compared to other herbal formulations and combined treatment modalities, focusing on reductions in menstrual pain intensity, duration, and analgesic use. Personalized herbal treatments were hypothesized to alleviate symptoms more effectively by addressing individual constitutional imbalances.

Methods

This prospective observational study was conducted at 33 Korean medicine clinics and one Korean medicine hospital in South Korea, enrolling 135 participants. Based on the treatment they received, participants were categorized into three groups: herbal decoction only group (Decoction only Group, n = 82), herbal decoction with adjunctive therapies such as acupuncture or moxibustion (Combination Group, n = 37), and non-herbal decoction formulations (Non-decoction Group, n = 16). Treatments were administered over at least one menstrual cycle, and outcomes were assessed after each cycle. Primary outcomes included changes in pain intensity (numerical rating scale), duration of menstrual pain, and frequency of analgesic use. Safety was assessed through adverse event monitoring during clinic visits.

Results

Herbal decoction only showed significant reductions in menstrual pain intensity, pain duration, and analgesic use compared to those receiving other herbal formulations. Most adverse events were mild gastrointestinal symptoms related to oral intake, which resolved without intervention. No serious adverse events were reported.

Conclusions

Herbal decoction group significantly decreased the intensity and duration of menstrual pain and analgesic dosage. These findings suggest that herbal decoction may be a safe and effective personalized treatment option for dysmenorrhea.

本研究旨在评价中药单方煎剂治疗痛经的有效性和安全性。将草药汤剂与其他草药配方和联合治疗方式进行比较，重点是减少月经疼痛强度、持续时间和止痛药的使用。假设个性化的草药治疗可以通过解决个人体质失衡来更有效地缓解症状。方法本前瞻性观察研究在韩国33家韩医诊所和1家韩医医院进行，纳入135名受试者。根据所接受的治疗，将参与者分为三组：单纯中药汤剂组（单纯中药汤剂组，n = 82）、中药汤剂加针灸等辅助治疗组（联合组，n = 37）和非中药汤剂组（非中药汤剂组，n = 16）。在至少一个月经周期内进行治疗，并在每个周期后评估结果。主要结局包括疼痛强度（数值评定量表）、月经疼痛持续时间和使用镇痛药频率的变化。通过临床访问期间的不良事件监测来评估安全性。结果与服用其他中药制剂的患者相比，复方凉保汤仅能显著减少月经疼痛强度、疼痛持续时间和镇痛药的使用。大多数不良事件是与口服摄入有关的轻微胃肠道症状，无需干预即可解决。无严重不良事件报告。结论人参汤组可显著降低痛经强度、持续时间及镇痛剂量。这些研究结果表明，中药汤剂可能是一种安全有效的治疗痛经的个性化选择。

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引用次数: 0

The Rome consensus: Good clinical trials for traditional medicine 罗马共识：传统医学的良好临床试验

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-31 DOI: 10.1016/j.imr.2025.101211

Junhua Zhang , Boli Zhang , Alice J. Fauci , Myeong Soo Lee , L. Susan Wieland , Iman Majd , Terje Alræk , Linda Zhong , Sergio Bangrazi , Aldo Liguori , Jingqing Hu , Yanming Xie , Jianyuan Tang , Zhongqi Yang , Paolo Landini , Annalisa Bucchi , Weian Yuan , Kam Wa Chan , Filomena Petti , Carlo Maria Giovanardi , Bo Pang

引用次数: 0

Exploring the potential transdiagnostic treatment effects of Chinese herbal medicine and acupuncture on insomnia disorder comorbid with chronic pain: A scoping review 探讨中药与针刺对失眠伴慢性疼痛的潜在跨诊断治疗效果：综述

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-29 DOI: 10.1016/j.imr.2025.101208

Yan Ling Kwok , Ran Wang , Hiu To Tang , Siyu Chen , Albert Yeung , Zhaoxiang Bian , Danny J. Yu

Background

Over 20 % of adults with insomnia disorder also experience chronic pain, termed insomnia disorder comorbid with chronic pain (ICCP), increasing risks for physical and mental diseases. Current treatments like cognitive behavioral therapy for insomnia show inconsistent pain relief, and non-opioid analgesics may exacerbate insomnia, underscoring the need for alternative approaches. Chinese herbal medicine (CHM) and acupuncture, guided by traditional Chinese medicine, may offer transdiagnostic benefits for ICCP, but a comprehensive review is lacking. This scoping review evaluates their therapeutic effects and mechanisms for ICCP.

Methods

PubMed, Wanfang, ClinicalTrials.gov and Google Scholar were searched up to December 31, 2024, for randomized controlled trials (RCTs) involving adults (≥18 years) with Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-defined insomnia and the International Association for the Study of Pain-defined chronic pain, treated with CHM or acupuncture. Effect sizes (modified Cohen’s d) assessed efficacy of interventions, and the Cochrane Risk of Bias 2 tool evaluated the risk of bias.

Results

Six RCTs (487 participants) were included. CHM (modified Guipi decoction) showed medium to large effects for insomnia (d = 0.70–1.17) and pain (d = 0.67–1.42) versus diazepam/estazolam. Acupuncture had medium to large effects for insomnia (d = 0.64–0.99) and pain (d = 0.80–1.33) compared to treatment as usual. Combined CHM (Da Huoluo capsules) and acupuncture showed medium effects (d = 0.72 for insomnia; d = 0.57 for pain) versus multi-medications/traction. Most studies (83.33 %) had high risk of bias.

Conclusion

CHM and acupuncture show promise for ICCP management, but high risk of bias warrants cautious interpretation and further high-quality RCTs.

背景：超过20%的成人失眠患者同时经历慢性疼痛，被称为失眠伴慢性疼痛（ICCP），增加了患身体和精神疾病的风险。目前的治疗方法，如认知行为疗法对失眠的缓解效果不一致，非阿片类镇痛药可能会加剧失眠，强调需要替代方法。中医指导下的中草药（CHM）和针灸可能为ICCP提供跨诊断益处，但缺乏全面的评价。本综述评估了它们对ICCP的治疗效果和机制。方法检索spubmed、万方、ClinicalTrials.gov和b谷歌Scholar，检索截至2024年12月31日的随机对照试验（rct），涉及成人（≥18岁），使用《精神障碍诊断与统计手册》第五版定义的失眠症和国际疼痛研究协会定义的慢性疼痛，接受中西医结合或针灸治疗。效应量（修正Cohen’s d）评估干预措施的疗效，Cochrane风险偏倚2工具评估偏倚风险。结果共纳入6项随机对照试验（rct），共487名受试者。桂皮汤对失眠（d = 0.70 ~ 1.17）和疼痛（d = 0.67 ~ 1.42）的治疗效果中~大。与常规治疗相比，针灸对失眠（d = 0.64-0.99）和疼痛（d = 0.80-1.33）有中等到较大的疗效。大活络胶囊联合针刺与多药联合牵引相比，疗效中等（失眠d = 0.72，疼痛d = 0.57）。大多数研究（83.33%）存在高偏倚风险。结论中西医结合针刺治疗ICCP有希望，但有较高的偏倚风险，需要谨慎解释和进一步的高质量随机对照试验。

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引用次数: 0

Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation 含有6种草药的“生脉山”改良配方，通过RhoA/Rho激酶介导的血管松弛，改善高血压

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-26 DOI: 10.1016/j.imr.2025.101207

Young Mi Seok , Hye-Lin Kim , Hyo In Kim , Hobin Moon , Yohan Han , Eun Sang Cho , Hyun Hee Leem , Hyo Jung Kim , Sujin Shin , Se-Jin Kim , Jin Ki Jung , Wei Huang , Kyung Oh Jung , Doo Suk Lee , Sung Giu Jin , Hyunwoo Kim , Changsop Yang , Kyungjin Lee , Jinbong Park

Background

Saengmaeksan is a traditional herbal formula used in Korean medicine. We composed a modified formula based on Saengmaeksan (mSMS) with Puerariae Radix, Platycodonis Radix, Liriopis seu Ophiopogonis Tuber, Schisandrae Fructus, Coicis Semen, and Dioscoreae Rhizoma to investigate its in vivo and ex vivo antihypertensive effects and underlying mechanisms.

Methods

The antihypertensive efficacy of mSMS was assessed using l-NAME-induced hypertensive mice and spontaneously hypertensive rats (SHR). The animals were treated with mSMS, and blood pressure was monitored weekly. Vascular effects were evaluated through organ bath studies and aortic histology, while oxidative stress was assessed using DCF-DA staining. Renal protection was examined via H&E and immunofluorescence staining for AT1R expression. The molecular mechanisms were explored through Western blot analysis and GTP-RhoA assays.

Results

mSMS significantly reduced systolic and diastolic blood pressure in both hypertensive models, with the ethanol extract demonstrating superior efficacy. mSMS inhibited the RhoA/Rho kinase pathway, leading to reduced phosphorylation of MYPT1 and CPI17, and improved vascular relaxation. Additionally, mSMS attenuated aortic wall thickening, oxidative stress, and renal damage, with a marked decrease in AT1R expression in the kidneys.

Conclusions

mSMS exhibits potent antihypertensive effects through the inhibition of the RhoA/Rho-kinase pathway, reduction of vascular remodeling, oxidative stress, and renal protection. These findings support the potential of mSMS as a novel therapeutic agent for hypertension, offering a multi-targeted approach with fewer side effects compared to conventional therapies. Further clinical studies are required to confirm its clinical efficacy.

生麦散是韩国医学中使用的传统草药配方。以葛根、桔梗、麦冬、五味子、薏苡仁、薯蓣为原料，研制了以生脉散为主要成分的复方制剂，研究其体内外抗高血压作用及其机制。方法以l- name诱导的高血压小鼠和自发性高血压大鼠（SHR）为实验对象，观察mSMS的降压效果。这些动物接受mSMS治疗，并每周监测血压。血管效应通过器官浴研究和主动脉组织学评估，氧化应激采用DCF-DA染色评估。通过H&；E和免疫荧光染色检测AT1R表达对肾脏的保护作用。通过Western blot分析和GTP-RhoA分析探讨其分子机制。结果smsms可显著降低两种高血压模型的收缩压和舒张压，其中乙醇提取物效果更佳。mSMS抑制RhoA/Rho激酶途径，导致MYPT1和CPI17磷酸化降低，改善血管舒张。此外，mSMS减轻了主动脉壁增厚、氧化应激和肾脏损伤，肾脏中AT1R表达显著降低。结论smsms通过抑制RhoA/ rho激酶通路、减少血管重构、氧化应激和肾保护作用，具有较强的降压作用。这些发现支持mSMS作为一种新型高血压治疗剂的潜力，与传统疗法相比，mSMS提供了一种多靶点的治疗方法，副作用更少。其临床疗效有待进一步的临床研究证实。

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引用次数: 0

The efficacy and safety of multiple acupuncture therapies in primary insomnia: A Bayesian network meta-analysis 多种针灸疗法治疗原发性失眠的疗效和安全性：一项贝叶斯网络meta分析

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-25 DOI: 10.1016/j.imr.2025.101206

Liguo Liu , Yiming Chen , Minne Tian , Zhennan Wu , Peiming Zhang , Tiankang Zhang , Jinsong Yang , Haotian Qu , Zhiyong Fan , Shan Wu , Liming Lu , Yu Kui

Background

Acupuncture (AT) therapy is an effective treatment for primary insomnia. However, no comprehensive study has compared and evaluated the efficacy and safety of multiple AT therapies and hypnotics.

Methods

We searched eight databases from inception to July 2024 for randomized controlled trials (RCTs) of AT treatment for primary insomnia, including PubMed, Web of Science, Embase, Cochrane Library, Wanfang database, China National Knowledge Infrastructure database, and VIP Chinese Science and Technique Journals database. After screening, the Pittsburgh Sleep Quality Index (PSQI) score and clinical effectiveness rate were extracted from the included RCTs as outcome measures. We performed network meta-analysis using the Stata and R software.

Results

Sixty-four RCTs involving 4443 patients were included in this study. Multiple AT therapies had better efficacy in improving PSQI scores than hypnotics, with AT combined with moxibustion (MOX) and AT combined with auriculotherapy (AU) as the best interventions. Regarding clinical effectiveness, acupoint catgut embedding (ACE) had the greatest potential of being the best intervention, and no serious adverse events related to AT therapies were observed in any of the studies.

Conclusion

This review suggests that most AT therapies improve sleep indicators and have good clinical efficacy compared to hypnotics, especially AT combined with AU, AT combined with MOX, and ACE. The safety of AT therapies is reliable; however, the overall quality of the included trials was low, and higher-quality RCTs are required to provide sufficient evidence.

Protocol registration

PROSPERO, CRD42017067402.

背景：针灸治疗是治疗原发性失眠的有效方法。然而，目前还没有全面的研究对多种AT疗法和催眠药物的疗效和安全性进行比较和评估。方法检索PubMed、Web of Science、Embase、Cochrane图书馆、万方数据库、中国国家知识基础设施数据库、VIP中国科技期刊数据库等8个数据库，检索自成立以来至2024年7月AT治疗原发性失眠的随机对照试验（rct）。筛选后，从纳入的随机对照试验中提取匹兹堡睡眠质量指数（PSQI）评分和临床有效率作为结局指标。我们使用Stata和R软件进行网络meta分析。结果共纳入64项随机对照试验，共4443例患者。多种AT治疗对PSQI评分的改善效果优于催眠治疗，其中AT联合艾灸（MOX）和AT联合耳穴治疗（AU）是最佳干预措施。在临床效果方面，穴位埋线（ACE）最有可能成为最佳干预措施，所有研究均未观察到与AT治疗相关的严重不良事件。结论与催眠药相比，大多数AT治疗均能改善睡眠指标，临床疗效较好，尤其是AT联合AU、AT联合MOX和ACE。AT疗法的安全性是可靠的；然而，纳入试验的总体质量较低，需要更高质量的随机对照试验来提供足够的证据。协议注册号prospero， CRD42017067402。

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引用次数: 0

Development of core outcome set for healthy aging treatment in primary care settings 初级保健机构健康老龄治疗的核心结果集的发展

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-19 DOI: 10.1016/j.imr.2025.101205

Soobin Jang , Hyein Jeong , Jungi Park , Mi Mi Ko , Jeeyoun Jung

Background

Healthy aging is a global public health priority, with increasing interest in the promotion of functional ability and well-being among older adults. South Korea’s rapidly aging population highlights the need for standardized evaluation tools for interventions. This study aimed to develop a Core Outcome Set (COS) for healthy aging treatment in primary care.

Methods

The COS was developed following the COS-STAD guidelines and through a multiphase process, including a literature review and a modified Delphi consensus. A project management group (PMG) reviewed studies related to health promotion programs and generated an initial list of outcomes. This list was refined through two rounds of Delphi surveys involving 16 experts. Consensus was assessed using content validity ratio, degree of consensus, and convergence.

Results

Twenty-six studies informed the initial outcome list, resulting in 24 outcomes for the Delphi evaluation. Two Delphi rounds and a final review by the PMG established a COS comprising 12 outcomes. These included EQ-5D, Geriatric Depression Scale, Instrumental Activities of Daily Living, body weight, blood pressure, blood glucose, blood lipids, liver function, kidney function, Korean Frailty Index, Self-rated Health, and Kidney-Deficiency Score.

Conclusions

The COS provides a standardized set of outcomes for evaluating healthy aging interventions in primary care. Its application in primary care and health promotion programs may enhance comparability across studies and support evidence-based decision making. Future revisions are recommended based on clinical applications and emerging research findings.

健康老龄化是全球公共卫生的优先事项，人们对促进老年人的功能能力和福祉越来越感兴趣。韩国人口的迅速老龄化凸显了对干预措施标准化评估工具的需求。本研究旨在建立一个核心结局集（COS），用于初级保健中的健康老龄化治疗。方法COS遵循COS- stad指南，经过多阶段的过程，包括文献回顾和修改的德尔菲共识。一个项目管理小组（PMG）审查了与健康促进计划有关的研究，并产生了初步的结果清单。这份名单是通过16位专家参与的两轮德尔菲调查来完善的。共识评估使用内容效度比，共识程度，和收敛。结果26项研究提供了初步结果表，得到24个德尔菲评价结果。两轮德尔菲和PMG的最后审查建立了一个包含12个结果的COS。这些包括EQ-5D、老年抑郁量表、日常生活工具活动、体重、血压、血糖、血脂、肝功能、肾功能、韩国虚弱指数、自评健康和肾虚评分。结论COS为评价初级保健中健康老龄化干预措施提供了一套标准化的结果。它在初级保健和健康促进计划中的应用可以增强研究之间的可比性，并支持循证决策。未来的修订建议基于临床应用和新兴的研究成果。

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引用次数: 0

Effectiveness and safety of combining pharmacopuncture therapy and acupotomy for treating patients with degenerative lumbar spinal stenosis: A pragmatic, assessor-blinded, randomized, controlled trial 药物穿刺联合针刀治疗退行性腰椎管狭窄的有效性和安全性：一项实用、评估盲、随机、对照试验

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-18 DOI: 10.1016/j.imr.2025.101204

Jihun Kim , Chang-Hyun Han , Taewook Lee , Sookwang An , Changsop Yang , Young Eun Choi , Byoung-Kab Kang , Yoona Oh , Kun Hyung Kim , Gi Young Yang , Eunseok Kim

Background

In the clinical practice of Korean Medicine, pharmacopuncture therapy and acupotomy (PA) are being increasingly explored as potential treatment options for degenerative lumbar spinal stenosis (LSS). In this study, we aimed to evaluate the effectiveness and safety of combining PA with conventional Korean Medicine treatment (CKMT) in patients with degenerative LSS.

Methods

A pragmatic, assessor-blinded, randomized controlled trial was conducted with 104 participants aged 40–75 years diagnosed with degenerative LSS. The participants were randomly assigned to either the CKMT+PA or CKMT alone groups over a 6-week period. The primary outcome was the mean change in the visual analog scale (VAS) for pain/discomfort. Secondary outcomes included clinically important differences (CID), Zurich Claudication Questionnaire, self-reported maximum walking distance, Roland-Morris Disability Questionnaire, EuroQol 5-dimension 5-level questionnaire, and patients’ global impression of change. The adverse events (AEs) were assessed at each visit.

Results

The CKMT+PA group showed significant improvements in VAS scores compared to the CKMT group at 6 weeks (adjusted mean difference: 20.26; 95 % confidence interval: 13.79–26.72, p < 0.0001), and a higher proportion of patients in the CKMT+PA group achieved the minimal CID in pain reduction. These improvements persisted at weeks 10 and 14. Superior results were also observed with respect to secondary outcomes in the CKMT+PA group compared to the CKMT group across all time points. CKMT showed no AEs, while mild AEs occurred in 1.7 % of bee venom and 2.2 % of acupotomy sessions.

Conclusion

Compared to CKMT alone, CKMT+PA offers significant improvements in pain relief, functional capacity, and quality of life in patients with degenerative LSS.

Trial registration

Clinical Research Information Service (CRIS) registry, KCT0008557.

在韩国医学的临床实践中，药物穿刺疗法和针刀（PA）正越来越多地被探索作为退行性腰椎管狭窄症（LSS）的潜在治疗选择。在本研究中，我们旨在评估PA联合传统韩药治疗（CKMT）治疗退行性LSS患者的有效性和安全性。方法对104例年龄40 ~ 75岁的退行性LSS患者进行了一项实用、评估盲、随机对照试验。参与者在6周的时间内被随机分配到CKMT+PA组或CKMT单独组。主要结局是疼痛/不适的视觉模拟评分（VAS）的平均变化。次要结局包括临床重要差异（CID）、苏黎世跛行问卷、自述最大步行距离、Roland-Morris残疾问卷、EuroQol 5维5级问卷、患者整体印象变化。每次就诊时对不良事件（ae）进行评估。结果与CKMT组相比，CKMT+PA组在6周时VAS评分有显著改善（调整平均差值：20.26；95%可信区间：13.79-26.72,p < 0.0001）， CKMT+PA组中更高比例的患者在疼痛减轻方面达到最小CID。这些改善持续到第10周和第14周。与CKMT组相比，CKMT+PA组在所有时间点的次要结果也优于CKMT组。CKMT未显示不良事件，而1.7%的蜂毒组和2.2%的针刀组出现轻度不良事件。结论与单纯CKMT治疗相比，CKMT+PA治疗可显著改善退行性LSS患者的疼痛缓解、功能能力和生活质量。临床研究信息服务（CRIS）注册，KCT0008557。

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引用次数: 0

From sound to science: Enhancing transparency in music-based therapeutic research 从声音到科学：提高音乐治疗研究的透明度

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-17 DOI: 10.1016/j.imr.2025.101203

Hyun Ju Chong

引用次数: 0