Integrative Medicine Research最新文献_第6页

Naming the unseen: Rethinking the ontology of acupoints 命名看不见的：穴位本体的再思考

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-07-05 DOI: 10.1016/j.imr.2025.101198

Beomku Kang, Younbyoung Chae

引用次数: 0

Mast cell degranulation mediates analgesic effects of acupuncture at different stimulation durations in arthritic rats 肥大细胞脱颗粒介导针刺不同刺激时间对关节炎大鼠的镇痛作用

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-26 DOI: 10.1016/j.imr.2025.101196

Yuhang Liu , Mingzhu Sun , Yixuan Wang , Yingchen Li , Ziliang Zhang , Liujie Ren , Wei Yao , Yi Yu

Background

To understand the effect and mechanism of different acupuncture durations on analgesic effects.

Methods

An adjuvant-induced arthritis rat model evaluated the therapeutic effects of acupuncture at the Zusanli acupoint (ST36). A robotic arm provided stable lifting-thrusting stimulation for different durations (2, 5, 10, 20, and 30 min). Mechanical and thermal pain thresholds were measured before and after treatment to assess the analgesic effects. Additionally, tissue sections from ST36 were stained and analyzed to assess mast cell degranulation rates, and in vitro stretching experiments were performed at different stretching times (0–60 min) to measure the release of histamine, 5-hydroxytryptamine, and leukotrienes.

Results

Within the 30 min acupuncture duration range set in this study, the pain threshold recovery rate in rats exhibited a steady upward trend as the acupuncture duration gradually increased, reaching its optimal level between 20 and 30 min. The mast cell degranulation rate exhibited a similar time-related trend, reaching 80–90 % at 20–30 min. Correlation analysis revealed a significant positive correlation between the pain threshold recovery rate and mast cell degranulation rate. In the cell-stretching experiment, the release of biochemical mediators was time-dependent.

Conclusions

In the adjuvant-induced arthritis rat model, the analgesic effect observed at 20–30 min was superior to that observed at shorter durations, which was associated with the mast cell degranulation rate and release of biochemical mediators in the tissue.

背景了解不同针刺时间对镇痛效果的影响及其机制。方法采用佐剂性关节炎大鼠模型，评价针刺足三里穴（ST36）的治疗效果。机械臂在不同的持续时间（2、5、10、20和30分钟）提供稳定的提升-推力刺激。治疗前后分别测量机械痛阈和热痛阈，评估镇痛效果。此外，对ST36的组织切片进行染色和分析，以评估肥大细胞脱颗粒率，并在不同的拉伸时间（0-60分钟）进行体外拉伸实验，以测量组胺、5-羟色胺和白三烯的释放。结果在本研究设定的30 min针刺持续时间范围内，大鼠痛阈恢复率随针刺持续时间的增加呈稳定上升趋势，在20 ~ 30 min达到最佳水平。肥大细胞脱颗粒率也表现出类似的时间相关趋势，在20 ~ 30 min达到80 ~ 90%，相关分析显示痛阈恢复率与肥大细胞脱颗粒率呈显著正相关。在细胞拉伸实验中，生化介质的释放具有时间依赖性。结论佐剂诱导的关节炎大鼠模型中，20 ~ 30min镇痛效果优于短时间镇痛，其镇痛效果与肥大细胞脱颗粒率及组织中生化介质的释放有关。

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引用次数: 0

Cochrane reviews of acupuncture are dated, do not account for the specific effects of sham controls and likely underestimate the efficacy of acupuncture therapy Cochrane关于针灸的综述是过时的，没有考虑到假对照的具体效果，可能低估了针灸治疗的疗效

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-21 DOI: 10.1016/j.imr.2025.101195

Arya Nielsen , L. Susan Wieland

Background

Because Cochrane reviews represent a quality standard for systematic reviews, we sought to clarify to what extent Cochrane reviews of acupuncture characterize the potential and problematic specific effects of sham acupuncture.

Methods

We imported records of Cochrane acupuncture reviews into Covidence and independently selected reviews with at least one included study comparing manual acupuncture to sham acupuncture. Dual data extraction for eligible reviews included review author expertise, evaluation of intervention adequacy, use of STRICTA guidelines, characterization of sham methods, and whether specific effects of sham were discussed relative to needle penetration, point selection or use of a sham device.

Results

Of the 56 reviews with acupuncture in the title, 16 were ineligible. Of the 40 included reviews, 28 were published in or before 2018. Most reviews had an author with acupuncture trial expertise; however, assessment of intervention adequacy was rarely conducted, STRICTA guidelines were rarely utilized, and reporting of sham acupuncture methods was commonly either missing or lacking rigor. While 20/40 reviews acknowledged the controversy regarding sham as an active and therefore inadequate control, no reviews incorporated this into their conclusions.

Conclusion

Most Cochrane reviews of acupuncture therapy are dated and are also not current relative to the science of acupuncture biomechanism and the impact of ‘active’ sham arms. The handling of sham controls, combined with a lack of evaluation of verum intervention adequacy, contravenes a clear research standard and indicates that the efficacy of acupuncture is likely underestimated in Cochrane reviews.

由于Cochrane综述代表了系统评价的质量标准，我们试图澄清针灸的Cochrane综述在多大程度上表征了假针灸的潜在和有问题的特定效果。方法我们将Cochrane针灸综述的记录导入到covid - ence中，并独立选择至少一项纳入比较手工针灸和假针灸的研究。对符合条件的综述的双重数据提取包括综述作者的专业知识、干预充分性的评估、STRICTA指南的使用、假手术方法的特征，以及是否讨论了假手术的具体效果与针穿、点的选择或假手术装置的使用有关。结果56篇以针灸为标题的综述中，16篇不合格。在纳入的40篇评论中，有28篇发表于2018年或之前。大多数评论都有一位具有针灸试验专业知识的作者；然而，很少进行干预充分性评估，很少使用STRICTA指南，并且假针灸方法的报告通常缺失或缺乏严谨性。虽然20/40的评论承认，假药作为一种积极的、因此不充分的控制存在争议，但没有评论将这一点纳入他们的结论。结论：大多数关于针灸治疗的Cochrane综述都是过时的，并且与针灸生物机制科学和“活动”假臂的影响也不相关。假对照的处理，加上缺乏对verum干预充分性的评估，违反了明确的研究标准，表明针灸的疗效在Cochrane综述中可能被低估了。

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引用次数: 0

Perspectives and dietary management of excess weight in polycystic ovary syndrome: A focus group study with clinicians of traditional Indian medicine 多囊卵巢综合征超重的观点和饮食管理：传统印度医学临床医生的焦点小组研究

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-19 DOI: 10.1016/j.imr.2025.101184

Vibhuti S. Rao , Sabrina Gupta , Mike Armour , Birinder S. Cheema , Caroline A Smith , Lisa Moran , Vandana Baranwal , Carolyn Ee

Background

Women with polycystic ovary syndrome (PCOS) use traditional medicines such as Ayurveda (traditional Indian medicine) to manage their symptoms. Dietary and lifestyle advice is one of the major components of Ayurveda treatment, however, it remains unexplored. This study aimed to understand the perspectives of Ayurveda clinicians regarding PCOS and excess weight, and its management through diet and lifestyle.

Methods

A qualitative methodology was implemented using online focus group discussion. The data were transcribed verbatim and analysed using content analysis. Ayurveda clinicians who fulfilled the predefined eligibility criteria were included.

Results

Ten eligible Ayurveda clinicians participated in the focus group. Five categories with relevant sub-categories were identified: characteristics of women visiting Ayurveda clinicians; Ayurveda clinical toolkit for understanding clinical presentations; Ayurveda dietary approach to managing excess weight; advice related to dietary adjustments; and advice related to eating and lifestyle behaviours. Overall, most clinicians agree that an Ayurveda dietary approach is personalized, and tailored to the health needs, primarily based on Ayurveda assessment and the clinical presentation of an individual with PCOS and excess weight.

Conclusion

Consistent with ‘Recommendations from the 2023 international evidence-based guideline for the assessment and management of PCOS’ Ayurveda clinicians advocate for a cultural-specific, lifelong healthy lifestyle for optimum management of PCOS beyond weight reduction. Ayurveda lifestyle counselling provides extensive insights into holistic food and lifestyle practices that individuals may adapt to their day-to-day lives. Further research may utilize consensus methods to explore potential dietary interventions and assess their effectiveness and adaptability in women with PCOS.

患有多囊卵巢综合征（PCOS）的妇女使用传统药物，如阿育吠陀（传统的印度药物）来控制她们的症状。饮食和生活方式建议是阿育吠陀治疗的主要组成部分之一，然而，它仍未被探索。本研究旨在了解阿育吠陀临床医生对多囊卵巢综合征和超重的看法，并通过饮食和生活方式进行管理。方法采用在线焦点小组讨论的定性方法。数据逐字转录，并使用内容分析进行分析。符合预定资格标准的阿育吠陀临床医生被纳入。结果10名符合条件的阿育吠陀临床医生参加了焦点小组。确定了五个类别及其相关的子类别：访问阿育吠陀临床医生的女性特征；用于理解临床表现的阿育吠陀临床工具包；阿育吠陀饮食方法管理超重；有关饮食调整的建议；以及有关饮食和生活方式行为的建议。总的来说，大多数临床医生都认为阿育吠陀饮食方法是个性化的，并根据健康需求量身定制，主要基于阿育吠陀评估和多囊卵巢综合征和超重患者的临床表现。结论与《2023年国际多囊卵巢综合征评估和管理循证指南》的建议一致，阿育吠陀临床医生提倡针对特定文化的终身健康生活方式，以优化多囊卵巢综合征的管理，而不仅仅是减肥。阿育吠陀生活方式咨询提供了广泛的见解，全面的食物和生活方式的做法，个人可以适应他们的日常生活。进一步的研究可能会利用共识方法来探索潜在的饮食干预措施，并评估其对PCOS女性的有效性和适应性。

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引用次数: 0

Bibliometrics and altmetrics in the context of traditional, complementary, and integrative medicine 文献计量学和替代计量学在传统、补充和综合医学的背景下

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-17 DOI: 10.1016/j.imr.2025.101181

Jeremy Y. Ng , Dimity Stephen , Jianping Liu , Thomas Ostermann , Nicola Robinson , Holger Cramer

This educational article explores the utility of bibliometrics and altmetrics in evaluating traditional, complementary, and integrative medicine (TCIM) research. We introduce the concept of bibliometrics and altmetrics, provide an overview of the opportunities and challenges in using these analytical techniques, and highlight their future potential in TCIM research. Bibliometrics, based on publication and citation information, offer insights into TCIM research activity, output, scholarly influence, field structure, and collaboration practices. Altmetrics, including social media mentions, downloads, and online bookmarks, can capture the broader societal engagement with TCIM research beyond traditional academic circles. We discuss challenges and opportunities in utilizing these metrics effectively, such as addressing biases, incorporating cultural nuances, and exploring emerging trends. Additionally, we issue a call to action for researchers, policymakers, and practitioners to collaborate and leverage bibliometric and altmetric data to advance evidence-based healthcare practices to promote integrative approaches to health and wellness. By embracing a multidimensional approach to research evaluation, stakeholders can harness the potential of bibliometrics and altmetrics to improve TCIM research and healthcare delivery worldwide.

这篇具有教育意义的文章探讨了文献计量学和替代计量学在评估传统、补充和综合医学（TCIM）研究中的应用。我们介绍了文献计量学和替代计量学的概念，概述了使用这些分析技术的机遇和挑战，并强调了它们在TCIM研究中的未来潜力。文献计量学基于出版物和引文信息，提供了对TCIM研究活动、产出、学术影响、领域结构和合作实践的见解。其他指标，包括社交媒体提及、下载和在线书签，可以捕捉到传统学术界之外更广泛的TCIM研究的社会参与。我们讨论了有效利用这些指标所面临的挑战和机遇，例如解决偏见、融入文化差异和探索新兴趋势。此外，我们呼吁研究人员、政策制定者和从业者合作，利用文献计量学和替代计量学数据，推进循证医疗实践，促进健康和保健的综合方法。通过采用多维度的研究评估方法，利益相关者可以利用文献计量学和替代计量学的潜力来改善全球TCIM研究和医疗保健服务。

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引用次数: 0

Corrigendum to: “Efficacy and safety of herbal medicine Gongjin-Dan and Ssanghwa-Tang in patients with chronic fatigue: A randomized, double-blind, placebo-controlled, clinical trial” Integr Med Res 2024;13:101025 《中药宫金丹和双花汤对慢性疲劳患者的疗效和安全性：一项随机、双盲、安慰剂对照的临床试验》的勘误表《综合医学杂志》2024；13:101025

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-16 DOI: 10.1016/j.imr.2025.101175

Jun-Yong Choi , Bom Choi , Ojin Kwon , Chang-Seob Seo , Ae-Ran Kim , Hyeun-kyoo Shin , Kibong Kim

引用次数: 0

Acupuncture treatment preserves soleus muscle mass and improves mitochondrial function in a rat model of disuse atrophy 针刺治疗保留比目鱼肌质量，改善废用性萎缩大鼠线粒体功能

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-16 DOI: 10.1016/j.imr.2025.101178

Sarah Mockler , Yun-Ju Fang , U-Ter Aondo Jia , Jinho Park , Joo Hyun Kim , Yoonjung Park , Adam J. Chicco , Masataka Umeda , Sukho Lee , Eunhee Chung

Background

Muscle atrophy leads to debilitating loss of physical capacity, particularly when alternative treatments are needed. Acupuncture is proposed as a potential therapy for disuse atrophy, but its effects on muscle biology remain unclear. This study evaluated the effects of acupuncture on soleus muscle mass and mitochondrial function in a rat model of immobilization-induced atrophy.

Methods

Female Sprague Dawley rats were assigned to three groups: Control (CON), casting-induced immobilization (CT), and CT with acupuncture (CT-A) (n = 8). Immobilization of the left hindlimb lasted for 14 days, and acupuncture was performed at specific acupoints (stomach-36, gallbladder-34) three times per week for 15 min. Mitochondrial function was assessed in saponin-permeabilized fibers, and signaling molecules regulating muscle mass were analyzed by Western blot.

Results

CT-A attenuated soleus muscle atrophy compared to CT. Under fatty acid substrate conditions, CT reduced complex I and II-supported oxidative phosphorylation (OXPHOS) compared to CON, while CT-A decreased respiratory leak and enhanced OXPHOS coupling relative to CT. Without fatty acids, CT-A decreased both respiratory leak and complex I and II-supported OXPHOS compared to CON, but differences between CT and CT-A were not significant. AMPKα activity (p-AMPKα/AMPKα) was significantly elevated in the CT group compared to the CON group, but returned to CON levels in the CT-A group. However, there were no changes in proteins associated with muscle atrophy or autophagy markers among the groups.

Conclusion

Acupuncture mitigates immobilization-induced muscle atrophy and preserves mitochondrial function, suggesting its potential as a therapeutic approach for muscle disuse conditions.

背景：肌肉萎缩导致身体机能的衰弱性丧失，特别是当需要替代治疗时。针刺被认为是废用性萎缩的潜在治疗方法，但其对肌肉生物学的影响尚不清楚。本研究评估了针刺对大鼠固定运动萎缩模型比目鱼肌质量和线粒体功能的影响。方法将雌性Sprague Dawley大鼠随机分为3组：对照组（CON）、穿刺固定组（CT）和针刺固定组（CT- a）。左后肢固定14天，针刺特定穴位（胃-36、胆囊-34），每周3次，每次15分钟。观察皂素渗透纤维的线粒体功能，并通过Western blot分析调节肌肉质量的信号分子。结果与CT相比，sct - a能减轻比目鱼肌萎缩。在脂肪酸底物条件下，与CON相比，CT减少了复合物I和ii支持的氧化磷酸化（OXPHOS），而CT- a相对于CT减少了呼吸泄漏并增强了OXPHOS偶联。在不含脂肪酸的情况下，与CON相比，CT- a减少了呼吸泄漏和复合物I和ii支持的OXPHOS，但CT和CT- a之间的差异不显著。与CON组相比，CT组AMPKα活性（p-AMPKα/AMPKα）显著升高，但在CT- a组恢复到CON水平。然而，与肌肉萎缩或自噬标志物相关的蛋白质在各组之间没有变化。结论针刺可减轻固定运动引起的肌肉萎缩，并保留线粒体功能，提示针刺可作为肌肉废用症的治疗方法。

{"title":"Acupuncture treatment preserves soleus muscle mass and improves mitochondrial function in a rat model of disuse atrophy","authors":"Sarah Mockler , Yun-Ju Fang , U-Ter Aondo Jia , Jinho Park , Joo Hyun Kim , Yoonjung Park , Adam J. Chicco , Masataka Umeda , Sukho Lee , Eunhee Chung","doi":"10.1016/j.imr.2025.101178","DOIUrl":"10.1016/j.imr.2025.101178","url":null,"abstract":"<div><h3>Background</h3><div>Muscle atrophy leads to debilitating loss of physical capacity, particularly when alternative treatments are needed. Acupuncture is proposed as a potential therapy for disuse atrophy, but its effects on muscle biology remain unclear. This study evaluated the effects of acupuncture on soleus muscle mass and mitochondrial function in a rat model of immobilization-induced atrophy.</div></div><div><h3>Methods</h3><div>Female Sprague Dawley rats were assigned to three groups: Control (CON), casting-induced immobilization (CT), and CT with acupuncture (CT-A) (<em>n</em> = 8). Immobilization of the left hindlimb lasted for 14 days, and acupuncture was performed at specific acupoints (stomach-36, gallbladder-34) three times per week for 15 min. Mitochondrial function was assessed in saponin-permeabilized fibers, and signaling molecules regulating muscle mass were analyzed by Western blot.</div></div><div><h3>Results</h3><div>CT-A attenuated soleus muscle atrophy compared to CT. Under fatty acid substrate conditions, CT reduced complex I and II-supported oxidative phosphorylation (OXPHOS) compared to CON, while CT-A decreased respiratory leak and enhanced OXPHOS coupling relative to CT. Without fatty acids, CT-A decreased both respiratory leak and complex I and II-supported OXPHOS compared to CON, but differences between CT and CT-A were not significant. AMPKα activity (p-AMPKα/AMPKα) was significantly elevated in the CT group compared to the CON group, but returned to CON levels in the CT-A group. However, there were no changes in proteins associated with muscle atrophy or autophagy markers among the groups.</div></div><div><h3>Conclusion</h3><div>Acupuncture mitigates immobilization-induced muscle atrophy and preserves mitochondrial function, suggesting its potential as a therapeutic approach for muscle disuse conditions.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 3","pages":"Article 101178"},"PeriodicalIF":2.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of the intention to use integrative medicine in psychiatric hospitals 精神病院使用中西医结合治疗意向的预测因素

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-14 DOI: 10.1016/j.imr.2025.101179

Corinne Schaub , Mohamed Faouzi , Julien Vonlanthen , Michaël Cordey , Pauline Marchand , Alexia Stantzos , Chantal BERNA , Kétia Alexandre

Background

The present study aimed to examine the influence of psychosocial and demographic factors on health professionals’ intention to integrate complementary and integrative medicine (CIM) into hospital-based psychiatric clinical practice. It also sought to validate the theoretical model derived from our previous exploratory study.

Method

A cross-sectional survey study using an online questionnaire sent to 4111 potential participants based on an adapted version of Triandis’ Theory of Interpersonal Behaviour (TIB).

Results

Participants reported high levels of positive attitudes towards CIM, with 61.6 % of the 1561 respondents reporting previous use in clinical practice and 37.8 % having received formal CIM training. Analysis of professionals’ intention to use CIM revealed four influential psychosocial factors - affect, perceived social norms, descriptive norms and past behaviour (p < 0.0001) - and three significant demographic factors - older age, a managerial position and fewer years of clinical practice (p < 0.05). With an area under the ROC curve of 95.53 %, the resulting model showed high discriminatory power and excellent fit.

Conclusions

These findings highlight the need for a supportive institutional environment to promote CIM. This requires the support of a wide range of professional leaders and the promotion of a shared CIM culture among healthcare professionals and interdisciplinary discussions.

本研究旨在探讨社会心理和人口因素对卫生专业人员将补充和结合医学（CIM）纳入医院精神病学临床实践的意向的影响。它还试图验证从我们之前的探索性研究中得出的理论模型。方法基于Triandis人际行为理论（TIB）的一个改编版本，采用一份在线调查问卷对4111名潜在参与者进行横断面调查研究。结果1561名受访者中有61.6%的人在临床实践中使用过CIM， 37.8%的人接受过正式的CIM培训。对专业人员使用CIM意向的分析揭示了四个影响心理社会因素——情感、感知社会规范、描述性规范和过去行为(p <；0.0001)，以及三个重要的人口统计学因素——年龄较大、管理职位和临床实践年数较少(p <；0.05)。该模型的ROC曲线下面积为95.53%，具有较高的判别能力和良好的拟合效果。结论：这些发现强调了促进CIM的支持性制度环境的必要性。这需要广泛的专业领导的支持，并在医疗保健专业人员和跨学科讨论中促进共享CIM文化。

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引用次数: 0

Should thread-embedding and auricular acupuncture be combined rather than used individually for non-specific chronic low back pain?: A double-blinded, randomized, sham-controlled trial 对于非特异性慢性腰痛，埋线和耳针是否应该联合使用，而不是单独使用？一项双盲、随机、假对照试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-13 DOI: 10.1016/j.imr.2025.101180

Thuy-Tu Long Pham , Nam Trung Le , Tin Trong Nguyen , Haoran Chu

Background

Non-specific chronic low back pain (NCLBP), the most common type, is a leading cause of global disability. The combined effect of thread-embedding acupuncture (TEA) and auricular acupuncture (AA) remains unclear. This study evaluates whether combining TEA and AA improves NCLBP management compared to either alone.

Methods

In this double-blind randomized controlled trial, 168 NCLBP patients were randomized into four groups (n = 42): TEA+AA, TEA+sham AA, AA+sham TEA, or sham both, alongside conventional treatment. The intervention lasted 4 weeks with a 4-week follow-up. The primary outcome was the Oswestry Disability Index (ODI); secondary outcomes included pain score, paracetamol use, quality of life, global improvement, and adverse events (AEs).

Results

In the intention-to-treat analysis, the acupuncture groups showed significantly lower ODI percentage scores compared to the sham group (p < 0.0001). Both the TEA+AA and TEA+sham AA groups outperformed the AA+sham TEA group (mean differences [MD]:9.1 and -7.5, respectively; p < 0.0001) at week 4 and achieved the minimal clinically important difference (MCID) during follow-up. The TEA+AA group showed greater improvement than the TEA+sham AA group at weeks 2 and 6; however, these differences did not reach the MCID. Secondary effectiveness outcomes followed a similar trend. The results were consistent with the per-protocol analysis. AEs were mild and self-limiting.

Conclusion

TEA and AA are safe and effective adjuncts for managing NCLBP, with TEA showing more sustained benefits. Adding AA into TEA may accelerate response, though clinical relevance remains uncertain. Further multicenter studies with longer follow-up and syndrome-based approaches are warranted.

Trial registration

ClinicalTrials.gov (NCT06682273).

非特异性慢性腰痛（NCLBP）是最常见的类型，是全球致残的主要原因。埋线针与耳针的联合作用尚不清楚。本研究评估与单独使用相比，TEA和AA联合使用是否能改善NCLBP的管理。方法在常规治疗的基础上，将168例NCLBP患者随机分为4组（n = 42）： TEA+AA组、TEA+假性AA组、AA+假性TEA组或两者均为假性TEA组。干预持续4周，随访4周。主要观察指标为Oswestry残疾指数（ODI）；次要结局包括疼痛评分、扑热息痛使用、生活质量、总体改善和不良事件（ae）。结果在意向治疗分析中，针刺组ODI百分比得分明显低于假手术组(p <；0.0001)。TEA+AA组和TEA+假性AA组均优于AA+假性TEA组(平均差异[MD]分别为9.1和-7.5；p & lt;0.0001)，并在随访期间达到最小临床重要差异（MCID）。在第2周和第6周，TEA+AA组比TEA+sham AA组有更大的改善；然而，这些差异没有达到MCID。次要有效性结果也遵循类似的趋势。结果与协议分析一致。ae是温和的和自我限制的。结论TEA和AA是治疗NCLBP安全有效的辅助手段，TEA疗效更持久。在TEA中加入AA可能会加速反应，但临床相关性仍不确定。进一步的多中心研究需要更长时间的随访和基于综合征的方法。试验注册：clinicaltrials .gov （NCT06682273）。

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引用次数: 0

Evaluating efficacy and safety of auricular acupressure in treating allergic rhinitis: A randomized controlled trial 评价耳穴按压治疗变应性鼻炎的疗效和安全性：一项随机对照试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-09 DOI: 10.1016/j.imr.2025.101177

Ngoc-Chau Le , Minh-Man Pham Bui , Dieu-Thuong Thi Trinh

Background

Allergic rhinitis significantly impacts health and quality of life, and symptom management remains a considerable challenge. This study aims to compare the treatment efficacy of auricular acupressure combined with fluticasone propionate versus fluticasone propionate alone for allergic rhinitis.

Methods

A randomized, double-blind, controlled clinical trial study was conducted with 90 patients diagnosed with allergic rhinitis according to ARIA 2008 guidelines. The control group (n = 45) received standard treatment, including fluticasone propionate, and sham auricular acupressure (SA), performed four times over four weeks. The intervention group (n = 45) received standard treatment with actual auricular acupressure (AA), performed four times over four weeks. Treatment efficacy was evaluated using a 100-mm visual analog scale (VAS) weekly and after four weeks of treatment, along with monitoring for adverse effects of auricular acupressure.

Results

After four weeks, the reduction in VAS scores for individual symptoms, including sneezing, runny nose, blocked nose, and itchy nose, showed mean differences between the control and intervention groups of 17.71 (95 % CI, 10.60–24.82); 22.73 (95 % CI, 15.71–29.76); 22.33 (95 % CI, 15.30–29.37); and 21.29 (95 % CI, 14.27–28.31) points, respectively (p < 0.0001). The RQLQ score, medication usage decreased significantly more in the intervention group than in the control group. Adverse effects were reported in 11.11 % of cases, mostly mild, transient, and not requiring additional treatment.

Conclusions

Auricular acupressure combined with fluticasone propionate provides effective and safe treatment for allergic rhinitis patients. Further interventional studies based on the classification of clinical syndromes in traditional medicine are warranted.

Trial registration: ClinicalTrials.gov, NCT06323304.

背景变应性鼻炎显著影响健康和生活质量，症状管理仍然是一个相当大的挑战。本研究旨在比较耳穴压联合丙酸氟替卡松与单用丙酸氟替卡松治疗变应性鼻炎的疗效。方法采用随机、双盲、对照临床试验方法，对90例根据ARIA 2008指南诊断为变应性鼻炎的患者进行研究。对照组（n = 45）给予标准治疗，包括丙酸氟替卡松和假耳穴按压（SA）， 4周内进行4次。干预组（n = 45）给予标准的实际耳穴按压（AA）治疗，4周内进行4次。采用100毫米视觉模拟量表（VAS）每周和治疗4周后评估治疗效果，同时监测耳穴按压的不良反应。结果4周后，对照组和干预组在打喷嚏、流鼻涕、鼻塞和鼻痒等症状的VAS评分下降，平均差异为17.71 (95% CI, 10.60-24.82)；22.73 (95% ci, 15.71 ~ 29.76)；22.33 (95% ci, 15.30-29.37)；和21.29 （95% CI, 14.27-28.31）点(p <；0.0001)。干预组RQLQ评分、用药情况下降明显高于对照组。11.11%的病例报告了不良反应，大多是轻微的，短暂的，不需要额外的治疗。结论穴位按压联合丙酸氟替卡松治疗变应性鼻炎安全有效。基于中医临床证候分类的进一步介入研究是有必要的。试验注册：ClinicalTrials.gov, NCT06323304。

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引用次数: 0