Integrative Medicine Research最新文献_第10页

Non-pharmacological interventions involving traditional Chinese medicine for assisted reproductive technology: A group consensus 中医药辅助生殖技术的非药物干预：群体共识

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-03-10 DOI: 10.1016/j.imr.2025.101137

Xinyue Li , Hye Won Lee , Tianyi Zhou , Nicola Robinson , Xiao-Yang Mio Hu , Momir Dunjić , Fangfang Wang , Rong Zhang , Consensus Panel , Yuhang Zhu , Fan Qu

Background

Assisted reproductive technologies (ART) are being increasingly utilized for mitigating fertility problems. Nonpharmacological interventions of traditional Chinese medicine (TCM) are widely used as an adjunct to ART, which may improve the rate of pregnancy. Currently, no standard treatment guidelines or consensus are available for non-pharmacological interventions of TCM for patients undergoing ART. The aim of this study was to establish a consensus on the use of non-pharmacological TCM interventions during the ART treatment cycle.

Methods

This study utilized existing data and developed a consensus among a panel of experts on non-pharmacological interventions of TCM for ART. Through face-to-face or online contact, the listed recommendations were revised one by one, and a consensus was reached when >70 % of the experts agreed with the recommendation. The writing group of the expert panel then created the first draft of the expert consensus based on the discussion in the first round. The second round was held to reach a consensus on content improvements based on the opinions of the experts in the previous round.

Results

After the literature search, a total of 873 related articles were retrieved, and 59 studies were ultimately included according to the inclusion and exclusion criteria. After two rounds of the survey, a total of 24 experts from 18 Chinese provinces across China and five international experts from the United Kingdom, Korea, and Serbia provided vital insight and support for the formulation of this consensus. The consensus outlines eight non-pharmacological interventions for seven different stages of the ART cycle and three major complications during ART, involving 23 items of clinical practice recommendations.

Conclusions

Expert consensus provides a foundation for integrating non-pharmacological TCM interventions into clinical practice during ART. As more high-quality, large-scale, multicenter clinical trials are conducted, these recommendations may be refined and updated to better inform clinical guidelines and improve patient outcomes in ART.

辅助生殖技术（ART）正越来越多地用于减轻生育问题。中医非药物干预被广泛应用于辅助抗逆转录病毒治疗，可以提高妊娠率。目前，对于接受抗逆转录病毒治疗的患者，中医药非药物干预尚无标准的治疗指南或共识。本研究的目的是建立在抗逆转录病毒治疗周期中使用非药物中医干预措施的共识。方法本研究利用现有数据，并在专家组中就中医药非药物干预抗逆转录病毒治疗达成共识。通过面对面或在线接触，对列出的建议逐一进行修订，当70%的专家同意建议时达成共识。专家组作文组在第一轮讨论的基础上，形成专家共识初稿。第二轮会议是在前一轮专家意见的基础上就内容改进达成共识。结果经文献检索，共检索到相关文献873篇，根据纳入和排除标准最终纳入59项研究。经过两轮调研，来自全国18个省区的24位专家和来自英国、韩国、塞尔维亚的5位国际专家为这一共识的形成提供了重要见解和支持。共识概述了针对抗逆转录病毒治疗周期的7个不同阶段和抗逆转录病毒治疗期间的3个主要并发症的8种非药物干预措施，涉及23项临床实践建议。结论专家共识为在抗逆转录病毒治疗过程中将中医非药物干预纳入临床实践提供了基础。随着更多高质量、大规模、多中心临床试验的开展，这些建议可能会得到完善和更新，以更好地为临床指南提供信息，并改善抗逆转录病毒治疗患者的结果。

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引用次数: 0

Integrative medicine and perinatal outcomes among women giving birth: A national population-based study in South Korea 韩国一项以人口为基础的全国性研究：分娩妇女中西医结合和围产期结局

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-02-28 DOI: 10.1016/j.imr.2025.101135

Seongju Kim , Jiae Choi , Hye Won Lee , Sunju Park

Background

The aim of this study was to examine the effects of integrative medicine (IM) on perinatal outcomes and health care utilization in women who gave birth in Korea.

Methods

This study used National Health Insurance Sharing Service (NHISS) claims data and established a retrospective cohort of all women who gave birth in Korea from January to December 2021. The women were categorized into IM and conventional medicine (CM) groups according to the nature of their health institution visits before delivery. To assess the risk of adverse perinatal outcomes between the two groups, a logistic regression model was used to estimate the odds ratio (OR) and the corresponding 95 % confidence interval (CI).

Results

A total of 171,136 women were divided into the IM (n = 91,902) and CM (n = 79,234) groups. Among the 9,608,545 claims analyzed, respiratory system disease was the most common primary diagnosis, followed by genitourinary system diseases. In the IM group, 19,153 claims were associated with infertility diagnosis codes, with the most frequent primary diagnoses being female infertility associated with anovulation and female infertility of other origins. Compared with the CM group, the IM group had significantly greater rates of assisted reproductive technology (ART) use (aOR, 1.25 [95 % CI, 1.21, 1.29]; P < 0.0001) and cesarean delivery (aOR, 1.08 [95 % CI, 1.06, 1.11]; P < 0.0001).

Conclusion

The study findings support that dual health care system use is not associated with the health outcomes of women who gave birth. The findings are expected to be valuable for establishing national health and medical policies or promoting health care utilization for women who give birth in South Korea.

背景：本研究的目的是研究中西医结合（IM）对韩国分娩妇女围产期结局和保健利用的影响。方法本研究使用国民健康保险共享服务（niss）索赔数据，并建立了一个回顾性队列，纳入了2021年1月至12月在韩国分娩的所有妇女。根据分娩前到卫生机构就诊的性质，将这些妇女分为IM组和传统医学组。为了评估两组之间不良围产期结局的风险，采用logistic回归模型估计优势比（OR）和相应的95%置信区间（CI）。结果共171136例女性分为IM组（n = 91902）和CM组（n = 79234）。在分析的9,608,545份索赔中，呼吸系统疾病是最常见的初级诊断，其次是泌尿生殖系统疾病。在IM组中，19,153例索赔与不孕症诊断代码相关，最常见的主要诊断是与无排卵相关的女性不孕症和其他原因的女性不孕症。与CM组相比，IM组辅助生殖技术（ART）使用率显著高于CM组(aOR, 1.25 [95% CI, 1.21, 1.29]；P & lt;0.0001)和剖宫产(aOR, 1.08 [95% CI, 1.06, 1.11]；P & lt;0.0001)。结论本研究结果支持双重医疗保健系统的使用与分娩妇女的健康结果无关。预计该研究结果将对制定国家卫生和医疗政策或促进韩国分娩妇女的卫生保健利用有价值。

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引用次数: 0

Exploring the potential of acupuncture practice education using artificial intelligence 利用人工智能探索针灸实践教育的潜力

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-01-23 DOI: 10.1016/j.imr.2025.101123

Kyeong Han Kim , Hyein Jeong , Gyeong Seo Lee , Seung-Hee Lee

Generative artificial intelligence (AI) is being applied in various areas such as education, clinical practice, and research within the medical field. This review explores the potential use of AI models in acupuncture practice education. Recent and relevant findings were searched from literature. Active research on the use of AI in acupuncture education, particularly in areas such as acupoint selection and acupuncture manipulation, is ongoing. Additionally, AI-powered educational tools are being developed in the field of traditional medicine. The development of AI-driven educational tools for acupuncture education holds significant potential to enhance the effectiveness and efficiency of traditional medicine education.

生成式人工智能（AI）正在医学领域的教育、临床实践、研究等各个领域得到应用。这篇综述探讨了人工智能模型在针灸实践教育中的潜在应用。从文献中检索了最近的相关发现。正在积极研究人工智能在针灸教育中的应用，特别是在穴位选择和针灸操作等领域。此外，传统医学领域正在开发人工智能教育工具。人工智能驱动的针灸教育工具的开发对提高传统医学教育的有效性和效率具有巨大的潜力。

引用次数: 0

Concerns about the use of verum acupuncture points in sham acupuncture studies for pain conditions: Findings and insights from network meta-analysis 在假针灸研究中使用verum穴位治疗疼痛：来自网络meta分析的发现和见解

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-01-10 DOI: 10.1016/j.imr.2025.101122

Boram Lee , Chan-Young Kwon , Hye Won Lee , Arya Nielsen , L Susan Wieland , Tae-Hun Kim , Stephen Birch , Terje Alraek , Myeong Soo Lee

引用次数: 0

Acupuncture-related therapy for chronic cough: A systematic review and meta-analysis 针灸治疗慢性咳嗽：一项系统综述和荟萃分析

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-01-02 DOI: 10.1016/j.imr.2025.101121

Boram Lee , Chan-Young Kwon , Yoon Kyoung Jeong , Na-Yeon Ha , Kwan-Il Kim , Beom-Joon Lee , Jun-Hwan Lee

Background

Despite the high prevalence and socioeconomic burden of chronic cough, there has been an unmet medical need. Acupuncture may be promising for treating chronic cough with various pathophysiologies involving several neurotransmission mechanisms. We aimed to systematically compile evidence on the effect and safety of acupuncture-related therapy for chronic cough.

Methods

Through a search of 11 databases, randomized controlled trials (RCTs) published until February 15, 2024 that evaluated the effect of acupuncture-related therapy at acupuncture points (including acupuncture, acupoint herbal patching, and moxibustion) for patients with chronic cough were identified and analyzed without restrictions on the cause of cough or age. When there were two or more studies that measured the same outcome measures, a meta-analysis was performed, and the certainty of evidence was evaluated based on the GRADE methodology.

Results

A total of 30 RCTs with 2835 participants were included. When acupuncture-related therapy was implemented in addition to conventional treatment including medicine and lifestyle guidance according to symptoms and causes, cough severity, cough-related quality of life, and the total effective rate (TER) were significantly improved with no difference in the incidence of adverse events. Furthermore, compared with conventional treatment, acupuncture-related therapy significantly improved cough severity and the TER. The certainty of the evidence was generally moderate due to the risk of bias. The most frequently used acupuncture points in the included studies were BL13, GV14, CV17, and EX-B1.

Conclusion

Acupuncture-related therapy might be an effective and safe treatment for patients with chronic cough of various causes with complex pathophysiologies.

Protocol registration

PROSPERO, CRD42024518115. PROSPERO (CRD42024518115).

背景：尽管慢性咳嗽的高流行率和社会经济负担，但一直存在未满足的医疗需求。针刺治疗慢性咳嗽具有多种病理生理机制，涉及多种神经传递机制。我们旨在系统地收集针灸治疗慢性咳嗽的疗效和安全性的证据。方法通过检索11个数据库，收集截至2024年2月15日发表的随机对照试验（RCTs），这些试验评估了穴位针灸相关治疗（包括针灸、穴位补片和艾灸）对慢性咳嗽患者的疗效，不受咳嗽原因或年龄的限制。当有两个或两个以上的研究测量相同的结果时，进行荟萃分析，并根据GRADE方法评估证据的确定性。结果共纳入30项随机对照试验，受试者2835人。在常规治疗的基础上，根据症状和原因进行药物治疗和生活方式指导，针刺相关治疗可显著改善咳嗽严重程度、咳嗽相关生活质量和总有效率（TER），但不良事件发生率无差异。此外，与常规治疗相比，针灸相关治疗可显著改善咳嗽严重程度和TER。由于存在偏倚风险，证据的确定性一般为中等。在纳入的研究中，最常用的穴位是BL13、GV14、CV17和EX-B1。结论针灸相关疗法对多种病因、病理生理复杂的慢性咳嗽是一种安全有效的治疗方法。协议注册：prospero， CRD42024518115。普洛斯彼罗(CRD42024518115)。

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引用次数: 0

Effect of acupressure on smoking cessation in young smokers with nicotine dependence: a mixed methods study 穴位按压对尼古丁依赖的年轻吸烟者戒烟的影响：一项混合方法研究

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-12-30 DOI: 10.1016/j.imr.2024.101120

Ying-Ying Zhang , Yi-Jie Liu , Yuan Wang , Chen Shen , Shi-Bing Liang , Nicola Robinson , Hai-Fa Qiao , Jian-Ping Liu

Background

Acupressure has been widely used for quitting smoking for a long time in China. This study explores the feasibility and effects of acupressure on smoking cessation in young smokers with nicotine dependence to inform policy and decision-making.

Methods

This was a single group study using pre/post-test design. Participants received four weeks of auricular acupressure treatment, led by a registered acupuncturist. Smoking cravings, nicotine dependence, withdrawal symptoms, and cigarettes per day (CPD) were recorded before and after treatment. Changes in outcomes were analyzed at 2 weeks and 4 weeks using SPSS software version 22.0. Semi-structured interviews were conducted with participants to explore their experience and attitude towards auricular acupressure. Thematic analysis was applied to analyze the data.

Results

A total of 20 participants completed this study. A significant reduction was observed in smoking cravings (F = 11.02, P < 0.05), nicotine dependence (F = 11.09, P < 0.05), withdrawal symptoms (F = 11.19, P < 0.05), and CPD (F = 19.03, P < 0.05) over sessions. Additionally, withdrawal symptoms decreased significantly from 2 weeks to 4 weeks (P < 0.05) of acupressure treatment. Three inter-related themes emerged from interviews: personal and external resources, psychological and physical effects of acupressure, and satisfaction with acupressure for smoking cessation.

Conclusion

The quantitative and qualitative data suggest that acupressure maybe effective in decreasing nicotine dependence and smoking cravings. However, this was a pilot and single arm study, these effects need to be further verified. The study supports the feasibility and safety of introducing acupressure therapy for smoking cessation in young smokers.

穴位按摩在中国长期以来被广泛用于戒烟。本研究旨在探讨穴位按压对尼古丁依赖青少年戒烟的可行性和效果，为政策和决策提供依据。方法采用前/后测试设计的单组研究。参与者在注册针灸师的指导下接受为期四周的耳穴按摩治疗。治疗前后记录吸烟渴望、尼古丁依赖、戒断症状和每天吸烟（CPD）。使用SPSS 22.0软件分析2周和4周时结果的变化。采用半结构式访谈，探讨参与者对耳穴按压的体验和态度。采用主题分析法对数据进行分析。结果共20名受试者完成本研究。吸烟渴望显著降低(F = 11.02, P <；0.05)、尼古丁依赖(F = 11.09, P <；0.05)、戒断症状(F = 11.19, P <；0.05), CPD (F = 19.03, P <；0.05)。此外，戒断症状从2周到4周显著减少(P <；0.05)。访谈中出现了三个相互关联的主题：个人和外部资源，穴位按压的心理和身体效果，以及对穴位按压戒烟的满意度。结论定量和定性数据表明，穴位按压可有效降低尼古丁依赖和吸烟渴望。然而，这是一项试点和单组研究，这些效果需要进一步验证。本研究支持穴位按压疗法对年轻吸烟者戒烟的可行性和安全性。

{"title":"Effect of acupressure on smoking cessation in young smokers with nicotine dependence: a mixed methods study","authors":"Ying-Ying Zhang , Yi-Jie Liu , Yuan Wang , Chen Shen , Shi-Bing Liang , Nicola Robinson , Hai-Fa Qiao , Jian-Ping Liu","doi":"10.1016/j.imr.2024.101120","DOIUrl":"10.1016/j.imr.2024.101120","url":null,"abstract":"<div><h3>Background</h3><div>Acupressure has been widely used for quitting smoking for a long time in China. This study explores the feasibility and effects of acupressure on smoking cessation in young smokers with nicotine dependence to inform policy and decision-making.</div></div><div><h3>Methods</h3><div>This was a single group study using pre/post-test design. Participants received four weeks of auricular acupressure treatment, led by a registered acupuncturist. Smoking cravings, nicotine dependence, withdrawal symptoms, and cigarettes per day (CPD) were recorded before and after treatment. Changes in outcomes were analyzed at 2 weeks and 4 weeks using SPSS software version 22.0. Semi-structured interviews were conducted with participants to explore their experience and attitude towards auricular acupressure. Thematic analysis was applied to analyze the data.</div></div><div><h3>Results</h3><div>A total of 20 participants completed this study. A significant reduction was observed in smoking cravings (<em>F</em> = 11.02, <em>P</em> < 0.05), nicotine dependence (<em>F</em> = 11.09, <em>P</em> < 0.05), withdrawal symptoms (<em>F</em> = 11.19, <em>P</em> < 0.05), and CPD (<em>F</em> = 19.03, <em>P</em> < 0.05) over sessions. Additionally, withdrawal symptoms decreased significantly from 2 weeks to 4 weeks (<em>P</em> < 0.05) of acupressure treatment. Three inter-related themes emerged from interviews: personal and external resources, psychological and physical effects of acupressure, and satisfaction with acupressure for smoking cessation.</div></div><div><h3>Conclusion</h3><div>The quantitative and qualitative data suggest that acupressure maybe effective in decreasing nicotine dependence and smoking cravings. However, this was a pilot and single arm study, these effects need to be further verified. The study supports the feasibility and safety of introducing acupressure therapy for smoking cessation in young smokers.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101120"},"PeriodicalIF":2.8,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common adverse events of herbal formulas for developing reporting forms for clinical practice and research: An overview of systematic reviews 为临床实践和研究制定报告表格的草药配方常见不良事件：系统评价概述

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-12-28 DOI: 10.1016/j.imr.2024.101118

Eunbyul Cho , Sungha Kim , Mi Ju Son

Background

Previous research has mainly focused on the adverse events (AEs) of individual medicinal plants rather than those of herbal formulas. This study investigated AEs associated with herbal formulas composed of two or more herbs by summarizing existing systematic reviews (SRs). We aimed to identify common AEs to develop a comprehensive reporting form for clinical practice and research, improving herbal medicine safety monitoring in South Korea.

Methods

Four international (MEDLINE, EMBASE, CENTRAL, CINAHL) and three Korean databases (KISS, ScienceON, OASIS) were searched for SRs on AEs associated with herbal formulas from inception to September 13, 2024. Inclusion criteria were SRs focusing on AEs of herbal formulas composed of two or more herbs. Two researchers independently conducted the search, selection, and data extraction. Methodological and reporting quality were evaluated using A MeaSurement Tool to Assess systematic Reviews 2 and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 checklist. AEs were classified using the System Organ Class of the Medical Dictionary for Regulatory Activities.

Results

Thirteen SRs were selected. The most frequently reported organ system was hepatobiliary (9 SRs), followed by nervous and gastrointestinal systems (3 SRs each). Common symptoms in primary studies were nausea (n = 102), diarrhea (n = 80), and vomiting (n = 70). Causality was analyzed in 7 SRs using various scales. The methodological quality of the included SRs was critically low.

Conclusions

Our findings provide a foundation for developing a standardized AE reporting form for herbal formulas. Further high-quality reports with specific patient conditions, herbal constituents, and causality assessments are required to enhance herbal medicine safety monitoring and understanding.

Protocol registration

PROSPERO, CRD42023478440.

以往的研究主要集中在单个药用植物的不良事件，而不是草药配方的不良事件。本研究通过总结现有的系统评价（SRs），调查了两种或两种以上草药组成的草药配方相关的ae。我们的目标是确定常见的ae，为临床实践和研究开发一个全面的报告表格，改善韩国的草药安全监测。方法检索4个国际数据库（MEDLINE、EMBASE、CENTRAL、CINAHL）和3个韩国数据库（KISS、ScienceON、OASIS），检索自成立至2024年9月13日与中药配方相关的ae的ssr。纳入标准是关注由两种或两种以上草药组成的中草药配方ae的SRs。两位研究人员独立进行了搜索、选择和数据提取。使用评估系统评价的测量工具2和2020年系统评价和荟萃分析的首选报告项目清单来评估方法学和报告质量。使用《医学词典》中的系统器官类对ae进行分类。结果共筛选出13例SRs。最常报道的器官系统是肝胆（9例），其次是神经系统和胃肠道（各3例）。初步研究的常见症状是恶心（n = 102）、腹泻（n = 80）和呕吐（n = 70）。采用不同量表对7例SRs进行因果关系分析。纳入的SRs的方法学质量非常低。结论本研究结果为制定标准化的中药配方AE报告表提供了基础。需要进一步的高质量报告，包括具体的患者情况、草药成分和因果关系评估，以加强草药安全监测和理解。协议注册普洛斯普洛斯，CRD42023478440。

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引用次数: 0

Patient-Focused Drug Development and Real World Study 以患者为中心的药物开发和现实世界研究

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-12-27 DOI: 10.1016/j.imr.2024.101119

Haiyin Hu , Hui Wang , Lin Ang , Menglong Shi , Xiaolei Wu , Chenyao Zhang , Mei Han , Shigang Liu , Kai Li , Junhua Zhang , Zhaochen Ji

Background

Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.

Methods

After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.

Results

PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.

Conclusions

Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.

以患者为中心的药物开发（PFDD）是医学研究领域的一个重要方向，对医学的发展具有重要意义。近年来，PFDD和现实世界研究（real-world study， RWS）得到了越来越多的关注，两者都有各自的优点。本研究旨在促进研究方法创新，优化临床研究设计与实施。方法在简要介绍PFDD和RWS的基础上，从目标、人群、干预、比较物、结局（PICO）要素、研究团队成员、数据采集、研究重点等方面对PFDD和RWS的临床试验进行比较，阐明“以患者为中心”的RWS研究模式的可行性和意义。结果dd强调在整个研究过程中应考虑患者的需求以及患者的意愿和满意度，在研究开发和用药过程中应收集患者的体验数据。RWS强调研究实施环境的真实性和患者来源的广度，涉及研究结果的外推、临床定位和靶药的患者适用性问题。然而，上述两者之间存在联系。PFDD和RWS的临床试验都给患者带来了益处。结论将PFDD思想与RWS研究方法相结合，开展新的研究，使患者获益最大化。将PFDD概念与RWS相结合的研究模型，有利于药物的开发和传播，可推广应用于各个研究领域。本研究可以创新研究方法，为今后的研究提供新的思路。

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引用次数: 0

Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial 比较穿透针与非穿透针电刺激联合运动训练对慢性阻塞性肺疾病患者呼吸困难的缓解和运动耐量的提高：一项单盲随机对照试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-12-27 DOI: 10.1016/j.imr.2024.101117

Ying He , Gui-yuan Li , Chun-zhi Tang , Li-ming Lu , Guang-yi Xiong , Yi Gao , Juan Tong , Guang-en Zhong

Background

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.

Method

A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.

Results

The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14^th treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO₂/kg%, V_E%, VO₂/HR%, V_Emax, V_E/VO₂ and V_E/VCO₂ in the PE group improved, especially VO₂/kg%, V_E%, V_Emax, V_E/VO₂ and V_E/VCO₂ were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.

Conclusion

Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.

Trial Registration

Chinese Clinical Trial Registry, ChiCTR1900028627.

慢性阻塞性肺疾病（COPD）以持续气流受限为特征。本研究的目的是评估电刺激刺穿针结合运动训练对缓解COPD患者呼吸困难和提高运动耐量的有效性。方法共招募85例患者，随机分为两组，一组接受电刺激穿刺针（PE）治疗，另一组接受电刺激非穿刺针（NPE）治疗，每周3次，共24次，共8周。两组都进行了运动训练。评估分别在基线、14次治疗后和24次治疗后进行。结果PE组在第14次治疗后6分钟步行距离（6MWD）有明显改善。肺功能检查，PE组MVV%、MEF50%、MEF75%、MEF25%均有改善，尤其是MVV%明显高于NPE组。心肺运动试验中，PE组的METs%、VO2/kg%、VE%、VO2/HR%、VEmax、VE/VO2、VE/VCO2均有改善，尤其是VO2/kg%、VE%、VEmax、VE/VO2、VE/VCO2均显著高于NPE组。PE组COPD评估测试得分明显提高。治疗后PE组改良英国医学研究理事会评分优于NPE组。结论电刺激刺穿针联合运动训练在缓解慢性阻塞性肺病患者呼吸困难和提高运动耐量方面具有临床应用价值。中国临床试验注册中心，ChiCTR1900028627。

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引用次数: 0

Intranasal acupuncture therapy for allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials 鼻内针刺治疗变应性鼻炎：随机对照试验的系统回顾和荟萃分析

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2024-12-26 DOI: 10.1016/j.imr.2024.101116

Xiao-ying Chen , Qian-yun Wang , Zhan-feng Yan , Yu-yang Wang , Xing-ru Pan , Meng-yuan Ou , Xue-han Liu , Jian-ping Liu , Xin-yan Jin

Background

Allergic rhinitis (AR) is a prevalent allergic condition that affects the nasal mucosa. Intranasal acupuncture therapy (IAT), an innovative therapy that involves precisely inserting acupuncture needles into specific nasal acupoints, has demonstrated potential effects in managing AR. The aim of this study is to evaluate the effectiveness and safety of IAT in the management of AR.

Methods

Nine databases were systematically searched for randomized controlled trials (RCTs) from their inception to September 2024. We included participants diagnosed with AR who received IAT alone or as add-on treatment to conventional treatment. The Cochrane risk of bias 2.0 tool and GRADE approach were applied to assess methodological qualities. A meta-analysis was performed using RevMan 5.4.1 software.

Results

Twenty-one RCTs with 1889 participants were included. The certainty of evidence was generally low and moderate. Compared to sham acupuncture, IAT significantly reduced the total nasal symptom score (MD −2.65, 95% CI −4.01 to −1.29, 1 RCT, 30 participants, moderate evidence). Compared to an antihistamine, IAT was associated with a lower total non-nasal symptom score (MD −0.44, 95% CI −0.64 to −0.25, 5 RCTs, 295 participants, moderate evidence) and a better quality of life measured by the rhinoconjunctivitis quality of life questionnaire (MD −13.72, 95% CI −18.01 to −9.43, 4 RCTs, 255 participants, moderate evidence). No serious adverse events were reported.

Conclusion

IAT may be beneficial in improving AR-related symptoms and quality of life. However, the safety of IAT remains unclear due to inadequate reporting. Further high-quality, rigorously designed, and well-reported trials are required.

Protocol registration

PROSPERO, CRD42024526357.

背景：变应性鼻炎（AR）是一种常见的影响鼻黏膜的过敏性疾病。鼻内针灸疗法（IAT）是一种创新的治疗方法，它将针刺针精确地插入特定的鼻腔穴位，已经证明了治疗AR的潜在效果。本研究的目的是评估IAT治疗AR的有效性和安全性。方法系统地检索从建立到2024年9月的随机对照试验（rct）数据库。我们纳入了诊断为AR的参与者，他们单独接受IAT或作为常规治疗的附加治疗。采用Cochrane偏倚风险2.0工具和GRADE方法评估方法学质量。采用RevMan 5.4.1软件进行meta分析。结果共纳入21项随机对照试验，受试者1889人。证据的确定性一般是低和中等的。与假针灸相比，IAT显著降低了鼻症状总评分（MD为- 2.65,95% CI为- 4.01至- 1.29,1项随机对照试验，30名受试者，中度证据）。与抗组胺药相比，IAT与较低的非鼻症状总评分（MD - 0.44, 95% CI - 0.64至- 0.25,5个随机对照试验，295名受试者，中等证据）和鼻结膜炎生活质量问卷测量的更好的生活质量相关（MD - 13.72, 95% CI - 18.01至- 9.43,4个随机对照试验，255名受试者，中等证据）。无严重不良事件报告。结论iat可能有利于改善ar相关症状和生活质量。然而，由于报道不足，IAT的安全性仍不清楚。需要进一步的高质量、严格设计和充分报告的试验。协议注册普洛斯普洛斯，CRD42024526357。

{"title":"Intranasal acupuncture therapy for allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials","authors":"Xiao-ying Chen , Qian-yun Wang , Zhan-feng Yan , Yu-yang Wang , Xing-ru Pan , Meng-yuan Ou , Xue-han Liu , Jian-ping Liu , Xin-yan Jin","doi":"10.1016/j.imr.2024.101116","DOIUrl":"10.1016/j.imr.2024.101116","url":null,"abstract":"<div><h3>Background</h3><div>Allergic rhinitis (AR) is a prevalent allergic condition that affects the nasal mucosa. Intranasal acupuncture therapy (IAT), an innovative therapy that involves precisely inserting acupuncture needles into specific nasal acupoints, has demonstrated potential effects in managing AR. The aim of this study is to evaluate the effectiveness and safety of IAT in the management of AR.</div></div><div><h3>Methods</h3><div>Nine databases were systematically searched for randomized controlled trials (RCTs) from their inception to September 2024. We included participants diagnosed with AR who received IAT alone or as add-on treatment to conventional treatment. The Cochrane risk of bias 2.0 tool and GRADE approach were applied to assess methodological qualities. A meta-analysis was performed using RevMan 5.4.1 software.</div></div><div><h3>Results</h3><div>Twenty-one RCTs with 1889 participants were included. The certainty of evidence was generally low and moderate. Compared to sham acupuncture, IAT significantly reduced the total nasal symptom score (MD −2.65, 95% CI −4.01 to −1.29, 1 RCT, 30 participants, moderate evidence). Compared to an antihistamine, IAT was associated with a lower total non-nasal symptom score (MD −0.44, 95% CI −0.64 to −0.25, 5 RCTs, 295 participants, moderate evidence) and a better quality of life measured by the rhinoconjunctivitis quality of life questionnaire (MD −13.72, 95% CI −18.01 to −9.43, 4 RCTs, 255 participants, moderate evidence). No serious adverse events were reported.</div></div><div><h3>Conclusion</h3><div>IAT may be beneficial in improving AR-related symptoms and quality of life. However, the safety of IAT remains unclear due to inadequate reporting. Further high-quality, rigorously designed, and well-reported trials are required.</div></div><div><h3>Protocol registration</h3><div>PROSPERO, CRD42024526357.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101116"},"PeriodicalIF":2.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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