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Mindfulness-based interventions for adults with type 2 diabetes mellitus: A systematic review and meta-analysis 正念为基础的干预成人2型糖尿病:系统回顾和荟萃分析
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1016/j.imr.2025.101138
Carolyn C Ee , Ieman Al-Kanini , Mike Armour , Milan K Piya , Rita McMorrow , Vibhuti S Rao , Dhevaksha Naidoo , Maria-Inti Metzendorf , Cynthia M Kroeger , Angelo Sabag

Background

Type 2 diabetes mellitus (T2DM) can lead to macro- and microvascular complications. Mindfulness-based interventions (MBIs) may improve metabolic and psychological health in individuals with T2DM. We aimed to assess the efficacy of MBIs for management of T2DM.

Methods

We searched five databases and two trial registries using a comprehensive search strategy developed by a multidisciplinary team including an information scientist. We included randomised controlled trials (RCTs) investigating MBIs for important clinical outcomes including psychological outcomes, quality of life, glycaemic control and cardiovascular risk factors in adults with T2DM. Where possible, random effects meta-analyses were conducted. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to assess certainty of the evidence.

Results

We included 31 RCTs (2337 participants: 1107 intervention, 1230 control). We found very low certainty evidence that MBIs may reduce stress (standardized mean difference (SMD) –1.01, confidence interval (CI) –1.91 to –0.20, 8 trials, n = 528), depression (SMD –1.26, CI –2.08 to –0.43; 7 trials, n = 570) and anxiety (SMD –0.67, CI –1.27 to –0.08; 4 studies, n = 255) at end of treatment compared to waitlist control/usual care. MBIs may have a small effect on HbA1c and systolic/diastolic blood pressure at end of treatment compared to waitlist control/usual care (HbA1c mean difference (MD) –0.44, 95 % CI –0.71 to –0.17, 9 trials, n = 734; low certainty evidence). There was very low certainty evidence that MBIs + lifestyle may have no effect on HbA1c or body weight compared to lifestyle alone.

Conclusion

MBIs may have clinical benefits (particularly psychological) for adults with T2DM, but lack of certainty in the evidence precludes clinical recommendations.

Protocol registration

Cochrane Database of Systematic Reviews, DOI: 10.1002/14651858.CD014881.
背景2型糖尿病(T2DM)可导致大血管和微血管并发症。正念干预(MBIs)可以改善T2DM患者的代谢和心理健康。我们的目的是评估mbi治疗T2DM的疗效。方法:我们使用包括一位信息科学家在内的多学科团队开发的综合检索策略,检索了5个数据库和2个试验注册库。我们纳入了随机对照试验(RCTs),研究mbi对成年T2DM患者的重要临床结果,包括心理结果、生活质量、血糖控制和心血管危险因素的影响。在可能的情况下,进行随机效应荟萃分析。采用推荐、评估、发展和评价分级(GRADE)方法评估证据的确定性。结果纳入31项随机对照试验(2337名受试者:干预1107名,对照组1230名)。我们发现非常低确定性的证据表明mbi可以减轻压力(标准化平均差(SMD) -1.01,可信区间(CI) -1.91至-0.20,8项试验,n = 528),抑郁(SMD -1.26, CI -2.08至-0.43;7项试验,n = 570)和焦虑(SMD -0.67, CI -1.27至-0.08;4项研究,n = 255)在治疗结束时与等候名单对照/常规护理相比。与等候名单对照/常规治疗相比,mbi对治疗结束时HbA1c和收缩压/舒张压的影响较小(HbA1c平均差值(MD) -0.44, 95 % CI -0.71至-0.17,9项试验,n = 734;低确定性证据)。有非常低的确定性证据表明,与单独的生活方式相比,mbi +生活方式可能对HbA1c或体重没有影响。结论:mbis对成人2型糖尿病患者可能有临床益处(尤其是心理上的),但缺乏确定性的证据妨碍了临床推荐。cochrane系统评价数据库,DOI: 10.002 /14651858. cd014881。
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引用次数: 0
Integrative medicine and perinatal outcomes among women giving birth: A national population-based study in South Korea 韩国一项以人口为基础的全国性研究:分娩妇女中西医结合和围产期结局
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-06-01 Epub Date: 2025-02-28 DOI: 10.1016/j.imr.2025.101135
Seongju Kim , Jiae Choi , Hye Won Lee , Sunju Park

Background

The aim of this study was to examine the effects of integrative medicine (IM) on perinatal outcomes and health care utilization in women who gave birth in Korea.

Methods

This study used National Health Insurance Sharing Service (NHISS) claims data and established a retrospective cohort of all women who gave birth in Korea from January to December 2021. The women were categorized into IM and conventional medicine (CM) groups according to the nature of their health institution visits before delivery. To assess the risk of adverse perinatal outcomes between the two groups, a logistic regression model was used to estimate the odds ratio (OR) and the corresponding 95 % confidence interval (CI).

Results

A total of 171,136 women were divided into the IM (n = 91,902) and CM (n = 79,234) groups. Among the 9,608,545 claims analyzed, respiratory system disease was the most common primary diagnosis, followed by genitourinary system diseases. In the IM group, 19,153 claims were associated with infertility diagnosis codes, with the most frequent primary diagnoses being female infertility associated with anovulation and female infertility of other origins. Compared with the CM group, the IM group had significantly greater rates of assisted reproductive technology (ART) use (aOR, 1.25 [95 % CI, 1.21, 1.29]; P < 0.0001) and cesarean delivery (aOR, 1.08 [95 % CI, 1.06, 1.11]; P < 0.0001).

Conclusion

The study findings support that dual health care system use is not associated with the health outcomes of women who gave birth. The findings are expected to be valuable for establishing national health and medical policies or promoting health care utilization for women who give birth in South Korea.
背景:本研究的目的是研究中西医结合(IM)对韩国分娩妇女围产期结局和保健利用的影响。方法本研究使用国民健康保险共享服务(niss)索赔数据,并建立了一个回顾性队列,纳入了2021年1月至12月在韩国分娩的所有妇女。根据分娩前到卫生机构就诊的性质,将这些妇女分为IM组和传统医学组。为了评估两组之间不良围产期结局的风险,采用logistic回归模型估计优势比(OR)和相应的95%置信区间(CI)。结果共171136例女性分为IM组(n = 91902)和CM组(n = 79234)。在分析的9,608,545份索赔中,呼吸系统疾病是最常见的初级诊断,其次是泌尿生殖系统疾病。在IM组中,19,153例索赔与不孕症诊断代码相关,最常见的主要诊断是与无排卵相关的女性不孕症和其他原因的女性不孕症。与CM组相比,IM组辅助生殖技术(ART)使用率显著高于CM组(aOR, 1.25 [95% CI, 1.21, 1.29];P & lt;0.0001)和剖宫产(aOR, 1.08 [95% CI, 1.06, 1.11];P & lt;0.0001)。结论本研究结果支持双重医疗保健系统的使用与分娩妇女的健康结果无关。预计该研究结果将对制定国家卫生和医疗政策或促进韩国分娩妇女的卫生保健利用有价值。
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引用次数: 0
Non-pharmacological interventions involving traditional Chinese medicine for assisted reproductive technology: A group consensus 中医药辅助生殖技术的非药物干预:群体共识
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI: 10.1016/j.imr.2025.101137
Xinyue Li , Hye Won Lee , Tianyi Zhou , Nicola Robinson , Xiao-Yang Mio Hu , Momir Dunjić , Fangfang Wang , Rong Zhang , Consensus Panel , Yuhang Zhu , Fan Qu

Background

Assisted reproductive technologies (ART) are being increasingly utilized for mitigating fertility problems. Nonpharmacological interventions of traditional Chinese medicine (TCM) are widely used as an adjunct to ART, which may improve the rate of pregnancy. Currently, no standard treatment guidelines or consensus are available for non-pharmacological interventions of TCM for patients undergoing ART. The aim of this study was to establish a consensus on the use of non-pharmacological TCM interventions during the ART treatment cycle.

Methods

This study utilized existing data and developed a consensus among a panel of experts on non-pharmacological interventions of TCM for ART. Through face-to-face or online contact, the listed recommendations were revised one by one, and a consensus was reached when >70 % of the experts agreed with the recommendation. The writing group of the expert panel then created the first draft of the expert consensus based on the discussion in the first round. The second round was held to reach a consensus on content improvements based on the opinions of the experts in the previous round.

Results

After the literature search, a total of 873 related articles were retrieved, and 59 studies were ultimately included according to the inclusion and exclusion criteria. After two rounds of the survey, a total of 24 experts from 18 Chinese provinces across China and five international experts from the United Kingdom, Korea, and Serbia provided vital insight and support for the formulation of this consensus. The consensus outlines eight non-pharmacological interventions for seven different stages of the ART cycle and three major complications during ART, involving 23 items of clinical practice recommendations.

Conclusions

Expert consensus provides a foundation for integrating non-pharmacological TCM interventions into clinical practice during ART. As more high-quality, large-scale, multicenter clinical trials are conducted, these recommendations may be refined and updated to better inform clinical guidelines and improve patient outcomes in ART.
辅助生殖技术(ART)正越来越多地用于减轻生育问题。中医非药物干预被广泛应用于辅助抗逆转录病毒治疗,可以提高妊娠率。目前,对于接受抗逆转录病毒治疗的患者,中医药非药物干预尚无标准的治疗指南或共识。本研究的目的是建立在抗逆转录病毒治疗周期中使用非药物中医干预措施的共识。方法本研究利用现有数据,并在专家组中就中医药非药物干预抗逆转录病毒治疗达成共识。通过面对面或在线接触,对列出的建议逐一进行修订,当70%的专家同意建议时达成共识。专家组作文组在第一轮讨论的基础上,形成专家共识初稿。第二轮会议是在前一轮专家意见的基础上就内容改进达成共识。结果经文献检索,共检索到相关文献873篇,根据纳入和排除标准最终纳入59项研究。经过两轮调研,来自全国18个省区的24位专家和来自英国、韩国、塞尔维亚的5位国际专家为这一共识的形成提供了重要见解和支持。共识概述了针对抗逆转录病毒治疗周期的7个不同阶段和抗逆转录病毒治疗期间的3个主要并发症的8种非药物干预措施,涉及23项临床实践建议。结论专家共识为在抗逆转录病毒治疗过程中将中医非药物干预纳入临床实践提供了基础。随着更多高质量、大规模、多中心临床试验的开展,这些建议可能会得到完善和更新,以更好地为临床指南提供信息,并改善抗逆转录病毒治疗患者的结果。
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引用次数: 0
Patient-Focused Drug Development and Real World Study 以患者为中心的药物开发和现实世界研究
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2024-12-27 DOI: 10.1016/j.imr.2024.101119
Haiyin Hu , Hui Wang , Lin Ang , Menglong Shi , Xiaolei Wu , Chenyao Zhang , Mei Han , Shigang Liu , Kai Li , Junhua Zhang , Zhaochen Ji

Background

Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.

Methods

After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.

Results

PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.

Conclusions

Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.
以患者为中心的药物开发(PFDD)是医学研究领域的一个重要方向,对医学的发展具有重要意义。近年来,PFDD和现实世界研究(real-world study, RWS)得到了越来越多的关注,两者都有各自的优点。本研究旨在促进研究方法创新,优化临床研究设计与实施。方法在简要介绍PFDD和RWS的基础上,从目标、人群、干预、比较物、结局(PICO)要素、研究团队成员、数据采集、研究重点等方面对PFDD和RWS的临床试验进行比较,阐明“以患者为中心”的RWS研究模式的可行性和意义。结果dd强调在整个研究过程中应考虑患者的需求以及患者的意愿和满意度,在研究开发和用药过程中应收集患者的体验数据。RWS强调研究实施环境的真实性和患者来源的广度,涉及研究结果的外推、临床定位和靶药的患者适用性问题。然而,上述两者之间存在联系。PFDD和RWS的临床试验都给患者带来了益处。结论将PFDD思想与RWS研究方法相结合,开展新的研究,使患者获益最大化。将PFDD概念与RWS相结合的研究模型,有利于药物的开发和传播,可推广应用于各个研究领域。本研究可以创新研究方法,为今后的研究提供新的思路。
{"title":"Patient-Focused Drug Development and Real World Study","authors":"Haiyin Hu ,&nbsp;Hui Wang ,&nbsp;Lin Ang ,&nbsp;Menglong Shi ,&nbsp;Xiaolei Wu ,&nbsp;Chenyao Zhang ,&nbsp;Mei Han ,&nbsp;Shigang Liu ,&nbsp;Kai Li ,&nbsp;Junhua Zhang ,&nbsp;Zhaochen Ji","doi":"10.1016/j.imr.2024.101119","DOIUrl":"10.1016/j.imr.2024.101119","url":null,"abstract":"<div><h3>Background</h3><div>Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.</div></div><div><h3>Methods</h3><div>After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.</div></div><div><h3>Results</h3><div>PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.</div></div><div><h3>Conclusions</h3><div>Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101119"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the potential of acupuncture practice education using artificial intelligence 利用人工智能探索针灸实践教育的潜力
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1016/j.imr.2025.101123
Kyeong Han Kim , Hyein Jeong , Gyeong Seo Lee , Seung-Hee Lee
Generative artificial intelligence (AI) is being applied in various areas such as education, clinical practice, and research within the medical field. This review explores the potential use of AI models in acupuncture practice education. Recent and relevant findings were searched from literature. Active research on the use of AI in acupuncture education, particularly in areas such as acupoint selection and acupuncture manipulation, is ongoing. Additionally, AI-powered educational tools are being developed in the field of traditional medicine. The development of AI-driven educational tools for acupuncture education holds significant potential to enhance the effectiveness and efficiency of traditional medicine education.
生成式人工智能(AI)正在医学领域的教育、临床实践、研究等各个领域得到应用。这篇综述探讨了人工智能模型在针灸实践教育中的潜在应用。从文献中检索了最近的相关发现。正在积极研究人工智能在针灸教育中的应用,特别是在穴位选择和针灸操作等领域。此外,传统医学领域正在开发人工智能教育工具。人工智能驱动的针灸教育工具的开发对提高传统医学教育的有效性和效率具有巨大的潜力。
{"title":"Exploring the potential of acupuncture practice education using artificial intelligence","authors":"Kyeong Han Kim ,&nbsp;Hyein Jeong ,&nbsp;Gyeong Seo Lee ,&nbsp;Seung-Hee Lee","doi":"10.1016/j.imr.2025.101123","DOIUrl":"10.1016/j.imr.2025.101123","url":null,"abstract":"<div><div>Generative artificial intelligence (AI) is being applied in various areas such as education, clinical practice, and research within the medical field. This review explores the potential use of AI models in acupuncture practice education. Recent and relevant findings were searched from literature. Active research on the use of AI in acupuncture education, particularly in areas such as acupoint selection and acupuncture manipulation, is ongoing. Additionally, AI-powered educational tools are being developed in the field of traditional medicine. The development of AI-driven educational tools for acupuncture education holds significant potential to enhance the effectiveness and efficiency of traditional medicine education.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101123"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methods for identifying health status from routinely collected health data: An overview 从常规收集的健康数据中确定健康状况的方法:概述。
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2024-11-15 DOI: 10.1016/j.imr.2024.101100
Mei Liu , Ke Deng , Mingqi Wang , Qiao He , Jiayue Xu , Guowei Li , Kang Zou , Xin Sun , Wen Wang
Routinely collected health data (RCD) are currently accelerating publications that evaluate the effectiveness and safety of medicines and medical devices. One of the fundamental steps in using these data is developing algorithms to identify health status that can be used for observational studies. However, the process and methodologies for identifying health status from RCD remain insufficiently understood. While most current methods rely on International Classification of Diseases (ICD) codes, they may not be universally applicable. Although machine learning methods hold promise for more accurately identifying the health status, they remain underutilized in RCD studies. To address these significant methodological gaps, we outline key steps and methodological considerations for identifying health statuses in observational studies using RCD. This review has the potential to boost the credibility of findings from observational studies that use RCD.
常规收集的健康数据(RCD)目前正在加速评估药品和医疗器械有效性和安全性的出版物。使用这些数据的一个基本步骤是开发算法,以确定可用于观察性研究的健康状况。然而,从RCD中确定健康状况的过程和方法仍然不够了解。虽然目前大多数方法依赖于国际疾病分类(ICD)代码,但它们可能并不普遍适用。尽管机器学习方法有望更准确地识别健康状态,但它们在RCD研究中仍未得到充分利用。为了解决这些重要的方法学差距,我们概述了使用RCD在观察性研究中识别健康状况的关键步骤和方法学考虑。这篇综述有可能提高使用RCD的观察性研究结果的可信度。
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引用次数: 0
Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial 8周Theracurmin Super (TS-P1)的疗效;姜黄素补充对运动诱导的氧化应激:一项随机、双盲、安慰剂对照的平行临床试验。
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2024-11-15 DOI: 10.1016/j.imr.2024.101099
Xinxing Li , Dae Young Kim , Yunho Sung , Donghyun Kim , Seohyun Ahn , Hyejung Shin , Nur Afiqah Binti Zulkifli , Ji-won Seo , Shu Jiang , Parivash Jamrasi , SoYoung Ahn , Jun Hyun Bae , HeeKyung Yeo , Hayoung Park , Wook Song

Background

Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.

Methods

Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, n = 36) or Placebo supplement group (PG, n = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, t-tests for group and within-group differences, and two-way ANOVA.

Results

In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state P = 0.021; oxidative stress index, resting state P = 0.020, end of exercise, P = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state P = 0.041) and oxidative stress index (resting state P = 0.018 and end of exercise P = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.

Conclusion

Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.

Trial registration

Clinical Research Information Service (CRIS): KCT0008731.
背景:鉴于姜黄素的抗氧化特性,本研究旨在确定Theracurmin Super补充剂在健康成人中减轻运动诱导的氧化应激的有效性和安全性。方法:于2022年4月至2023年3月在首尔国立大学对71名健康成人进行了研究。在第一次访问期间,通过使用布鲁斯跑步机方案评估最大耗氧量来确定患者的资格。在第2次访问中,参与者被随机分配到Theracurmin超级补充剂组(TG, n = 36)或安慰剂补充剂组(PG, n = 35)。在8周的时间里,参与者每天服用两次Theracurmin Super(姜黄素,120毫克/天)或安慰剂(姜黄素,0毫克/天),并访问实验室四次。在每次访问时评估各种参数,包括身体组成、生命体征、成人营养商数、心肺耐力、血液生物标志物和不良事件。统计分析包括协议分析、组内和组内差异的t检验和双向方差分析。结果:在第8周,与氧化应激相关的血液生物标志物,包括TBARs、MDA、8- ohdg、SOD、TOS和OSI,显示出显著的组和周相关相互作用(总氧化状态:静息状态P = 0.021;氧化应激指数,静息状态P = 0.020,运动结束P = 0.013)。值得注意的是,TG显示总氧化状态(静息状态P = 0.041)和氧化应激指数(静息状态P = 0.018,运动结束P = 0.008)在第0周至第8周之间显著下降。然而,MDA和8-OHdG水平没有统计学上的显著变化。结论:Theracurmin Super能有效降低运动前后的氧化应激,显示姜黄素在控制氧化应激中的重要作用。观察到TOS和OSI的显著改善,尽管MDA和8-OHdG水平的变化无统计学意义。进一步的研究可以深入了解这些不同氧化生物标志物的混合结果。试验注册:临床研究信息服务(CRIS): KCT0008731。
{"title":"Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial","authors":"Xinxing Li ,&nbsp;Dae Young Kim ,&nbsp;Yunho Sung ,&nbsp;Donghyun Kim ,&nbsp;Seohyun Ahn ,&nbsp;Hyejung Shin ,&nbsp;Nur Afiqah Binti Zulkifli ,&nbsp;Ji-won Seo ,&nbsp;Shu Jiang ,&nbsp;Parivash Jamrasi ,&nbsp;SoYoung Ahn ,&nbsp;Jun Hyun Bae ,&nbsp;HeeKyung Yeo ,&nbsp;Hayoung Park ,&nbsp;Wook Song","doi":"10.1016/j.imr.2024.101099","DOIUrl":"10.1016/j.imr.2024.101099","url":null,"abstract":"<div><h3>Background</h3><div>Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.</div></div><div><h3>Methods</h3><div>Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, <em>n</em> = 36) or Placebo supplement group (PG, <em>n</em> = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, <em>t</em>-tests for group and within-group differences, and two-way ANOVA.</div></div><div><h3>Results</h3><div>In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state <em>P</em> = 0.021; oxidative stress index, resting state <em>P</em> = 0.020, end of exercise, <em>P</em> = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state <em>P</em> = 0.041) and oxidative stress index (resting state <em>P</em> = 0.018 and end of exercise <em>P</em> = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.</div></div><div><h3>Conclusion</h3><div>Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS): KCT0008731.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101099"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial 比较穿透针与非穿透针电刺激联合运动训练对慢性阻塞性肺疾病患者呼吸困难的缓解和运动耐量的提高:一项单盲随机对照试验
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2024-12-27 DOI: 10.1016/j.imr.2024.101117
Ying He , Gui-yuan Li , Chun-zhi Tang , Li-ming Lu , Guang-yi Xiong , Yi Gao , Juan Tong , Guang-en Zhong

Background

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.

Method

A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.

Results

The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14th treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO2/kg%, VE%, VO2/HR%, VEmax, VE/VO2 and VE/VCO2 in the PE group improved, especially VO2/kg%, VE%, VEmax, VE/VO2 and VE/VCO2 were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.

Conclusion

Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.

Trial Registration

Chinese Clinical Trial Registry, ChiCTR1900028627.
慢性阻塞性肺疾病(COPD)以持续气流受限为特征。本研究的目的是评估电刺激刺穿针结合运动训练对缓解COPD患者呼吸困难和提高运动耐量的有效性。方法共招募85例患者,随机分为两组,一组接受电刺激穿刺针(PE)治疗,另一组接受电刺激非穿刺针(NPE)治疗,每周3次,共24次,共8周。两组都进行了运动训练。评估分别在基线、14次治疗后和24次治疗后进行。结果PE组在第14次治疗后6分钟步行距离(6MWD)有明显改善。肺功能检查,PE组MVV%、MEF50%、MEF75%、MEF25%均有改善,尤其是MVV%明显高于NPE组。心肺运动试验中,PE组的METs%、VO2/kg%、VE%、VO2/HR%、VEmax、VE/VO2、VE/VCO2均有改善,尤其是VO2/kg%、VE%、VEmax、VE/VO2、VE/VCO2均显著高于NPE组。PE组COPD评估测试得分明显提高。治疗后PE组改良英国医学研究理事会评分优于NPE组。结论电刺激刺穿针联合运动训练在缓解慢性阻塞性肺病患者呼吸困难和提高运动耐量方面具有临床应用价值。中国临床试验注册中心,ChiCTR1900028627。
{"title":"Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial","authors":"Ying He ,&nbsp;Gui-yuan Li ,&nbsp;Chun-zhi Tang ,&nbsp;Li-ming Lu ,&nbsp;Guang-yi Xiong ,&nbsp;Yi Gao ,&nbsp;Juan Tong ,&nbsp;Guang-en Zhong","doi":"10.1016/j.imr.2024.101117","DOIUrl":"10.1016/j.imr.2024.101117","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.</div></div><div><h3>Method</h3><div>A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.</div></div><div><h3>Results</h3><div>The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14<sup>th</sup> treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO<sub>2</sub>/kg%, V<sub>E</sub>%, VO<sub>2</sub>/HR%, V<sub>Emax</sub>, V<sub>E</sub>/VO<sub>2</sub> and V<sub>E</sub>/VCO<sub>2</sub> in the PE group improved, especially VO<sub>2</sub>/kg%, V<sub>E</sub>%, V<sub>Emax</sub>, V<sub>E</sub>/VO<sub>2</sub> and V<sub>E</sub>/VCO<sub>2</sub> were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.</div></div><div><h3>Conclusion</h3><div>Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.</div></div><div><h3>Trial Registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900028627.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101117"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The case for data sharing in traditional, complementary, and integrative medicine research 在传统、补充和综合医学研究中共享数据的案例。
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2024-11-14 DOI: 10.1016/j.imr.2024.101101
Jeremy Y. Ng
Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.
传统、补充和综合医学(TCIM)的研究包括植根于不同文化、哲学和历史框架的各种卫生实践。随着全球对开展该领域研究的兴趣日益浓厚,需要进行严格的研究,以支持将循证TCIM疗法整合到主流医疗保健中,这一点变得至关重要。通过加强可重复性、促进跨学科合作、促进伦理实践和应对全球卫生挑战,数据共享对于推进TCIM研究至关重要。尽管有诸多好处,但TCIM中的数据共享也面临许多挑战,包括缺乏标准化实践、文化敏感性、知识产权问题以及资源有限环境中的技术壁垒。这篇社论探讨了TCIM研究的独特性,强调了数据共享的重要性,同时承认其复杂性。落实CARE土著数据治理原则,优先考虑集体利益、控制权力、责任和道德,为确保数据共享尊重土著知识和文化敏感性提供了一个框架。克服数据共享障碍的战略包括制定标准化协议、投资于研究基础设施以及在TCIM社区内外培养开放与合作的文化。通过推进数据共享实践,TCIM研究可以为基于证据的医疗保健解决方案做出贡献,并解决全球健康差异,最终改善全球的健康结果。
{"title":"The case for data sharing in traditional, complementary, and integrative medicine research","authors":"Jeremy Y. Ng","doi":"10.1016/j.imr.2024.101101","DOIUrl":"10.1016/j.imr.2024.101101","url":null,"abstract":"<div><div>Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101101"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concerns about the use of verum acupuncture points in sham acupuncture studies for pain conditions: Findings and insights from network meta-analysis 在假针灸研究中使用verum穴位治疗疼痛:来自网络meta分析的发现和见解
IF 2.8 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-03-01 Epub Date: 2025-01-10 DOI: 10.1016/j.imr.2025.101122
Boram Lee , Chan-Young Kwon , Hye Won Lee , Arya Nielsen , L Susan Wieland , Tae-Hun Kim , Stephen Birch , Terje Alraek , Myeong Soo Lee
{"title":"Concerns about the use of verum acupuncture points in sham acupuncture studies for pain conditions: Findings and insights from network meta-analysis","authors":"Boram Lee ,&nbsp;Chan-Young Kwon ,&nbsp;Hye Won Lee ,&nbsp;Arya Nielsen ,&nbsp;L Susan Wieland ,&nbsp;Tae-Hun Kim ,&nbsp;Stephen Birch ,&nbsp;Terje Alraek ,&nbsp;Myeong Soo Lee","doi":"10.1016/j.imr.2025.101122","DOIUrl":"10.1016/j.imr.2025.101122","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101122"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Integrative Medicine Research
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