Pub Date : 2025-06-01Epub Date: 2025-03-20DOI: 10.1016/j.imr.2025.101138
Carolyn C Ee , Ieman Al-Kanini , Mike Armour , Milan K Piya , Rita McMorrow , Vibhuti S Rao , Dhevaksha Naidoo , Maria-Inti Metzendorf , Cynthia M Kroeger , Angelo Sabag
Background
Type 2 diabetes mellitus (T2DM) can lead to macro- and microvascular complications. Mindfulness-based interventions (MBIs) may improve metabolic and psychological health in individuals with T2DM. We aimed to assess the efficacy of MBIs for management of T2DM.
Methods
We searched five databases and two trial registries using a comprehensive search strategy developed by a multidisciplinary team including an information scientist. We included randomised controlled trials (RCTs) investigating MBIs for important clinical outcomes including psychological outcomes, quality of life, glycaemic control and cardiovascular risk factors in adults with T2DM. Where possible, random effects meta-analyses were conducted. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to assess certainty of the evidence.
Results
We included 31 RCTs (2337 participants: 1107 intervention, 1230 control). We found very low certainty evidence that MBIs may reduce stress (standardized mean difference (SMD) –1.01, confidence interval (CI) –1.91 to –0.20, 8 trials, n = 528), depression (SMD –1.26, CI –2.08 to –0.43; 7 trials, n = 570) and anxiety (SMD –0.67, CI –1.27 to –0.08; 4 studies, n = 255) at end of treatment compared to waitlist control/usual care. MBIs may have a small effect on HbA1c and systolic/diastolic blood pressure at end of treatment compared to waitlist control/usual care (HbA1c mean difference (MD) –0.44, 95 % CI –0.71 to –0.17, 9 trials, n = 734; low certainty evidence). There was very low certainty evidence that MBIs + lifestyle may have no effect on HbA1c or body weight compared to lifestyle alone.
Conclusion
MBIs may have clinical benefits (particularly psychological) for adults with T2DM, but lack of certainty in the evidence precludes clinical recommendations.
Protocol registration
Cochrane Database of Systematic Reviews, DOI: 10.1002/14651858.CD014881.
背景2型糖尿病(T2DM)可导致大血管和微血管并发症。正念干预(MBIs)可以改善T2DM患者的代谢和心理健康。我们的目的是评估mbi治疗T2DM的疗效。方法:我们使用包括一位信息科学家在内的多学科团队开发的综合检索策略,检索了5个数据库和2个试验注册库。我们纳入了随机对照试验(RCTs),研究mbi对成年T2DM患者的重要临床结果,包括心理结果、生活质量、血糖控制和心血管危险因素的影响。在可能的情况下,进行随机效应荟萃分析。采用推荐、评估、发展和评价分级(GRADE)方法评估证据的确定性。结果纳入31项随机对照试验(2337名受试者:干预1107名,对照组1230名)。我们发现非常低确定性的证据表明mbi可以减轻压力(标准化平均差(SMD) -1.01,可信区间(CI) -1.91至-0.20,8项试验,n = 528),抑郁(SMD -1.26, CI -2.08至-0.43;7项试验,n = 570)和焦虑(SMD -0.67, CI -1.27至-0.08;4项研究,n = 255)在治疗结束时与等候名单对照/常规护理相比。与等候名单对照/常规治疗相比,mbi对治疗结束时HbA1c和收缩压/舒张压的影响较小(HbA1c平均差值(MD) -0.44, 95 % CI -0.71至-0.17,9项试验,n = 734;低确定性证据)。有非常低的确定性证据表明,与单独的生活方式相比,mbi +生活方式可能对HbA1c或体重没有影响。结论:mbis对成人2型糖尿病患者可能有临床益处(尤其是心理上的),但缺乏确定性的证据妨碍了临床推荐。cochrane系统评价数据库,DOI: 10.002 /14651858. cd014881。
{"title":"Mindfulness-based interventions for adults with type 2 diabetes mellitus: A systematic review and meta-analysis","authors":"Carolyn C Ee , Ieman Al-Kanini , Mike Armour , Milan K Piya , Rita McMorrow , Vibhuti S Rao , Dhevaksha Naidoo , Maria-Inti Metzendorf , Cynthia M Kroeger , Angelo Sabag","doi":"10.1016/j.imr.2025.101138","DOIUrl":"10.1016/j.imr.2025.101138","url":null,"abstract":"<div><h3>Background</h3><div>Type 2 diabetes mellitus (T2DM) can lead to macro- and microvascular complications. Mindfulness-based interventions (MBIs) may improve metabolic and psychological health in individuals with T2DM. We aimed to assess the efficacy of MBIs for management of T2DM.</div></div><div><h3>Methods</h3><div>We searched five databases and two trial registries using a comprehensive search strategy developed by a multidisciplinary team including an information scientist. We included randomised controlled trials (RCTs) investigating MBIs for important clinical outcomes including psychological outcomes, quality of life, glycaemic control and cardiovascular risk factors in adults with T2DM. Where possible, random effects meta-analyses were conducted. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to assess certainty of the evidence.</div></div><div><h3>Results</h3><div>We included 31 RCTs (2337 participants: 1107 intervention, 1230 control). We found very low certainty evidence that MBIs may reduce stress (standardized mean difference (SMD) –1.01, confidence interval (CI) –1.91 to –0.20, 8 trials, <em>n</em> = 528), depression (SMD –1.26, CI –2.08 to –0.43; 7 trials, <em>n</em> = 570) and anxiety (SMD –0.67, CI –1.27 to –0.08; 4 studies, <em>n</em> = 255) at end of treatment compared to waitlist control/usual care. MBIs may have a small effect on HbA1c and systolic/diastolic blood pressure at end of treatment compared to waitlist control/usual care (HbA1c mean difference (MD) –0.44, 95 % CI –0.71 to –0.17, 9 trials, <em>n</em> = 734; low certainty evidence). There was very low certainty evidence that MBIs + lifestyle may have no effect on HbA1c or body weight compared to lifestyle alone.</div></div><div><h3>Conclusion</h3><div>MBIs may have clinical benefits (particularly psychological) for adults with T2DM, but lack of certainty in the evidence precludes clinical recommendations.</div></div><div><h3>Protocol registration</h3><div>Cochrane Database of Systematic Reviews, DOI: 10.1002/14651858.CD014881.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101138"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-02-28DOI: 10.1016/j.imr.2025.101135
Seongju Kim , Jiae Choi , Hye Won Lee , Sunju Park
Background
The aim of this study was to examine the effects of integrative medicine (IM) on perinatal outcomes and health care utilization in women who gave birth in Korea.
Methods
This study used National Health Insurance Sharing Service (NHISS) claims data and established a retrospective cohort of all women who gave birth in Korea from January to December 2021. The women were categorized into IM and conventional medicine (CM) groups according to the nature of their health institution visits before delivery. To assess the risk of adverse perinatal outcomes between the two groups, a logistic regression model was used to estimate the odds ratio (OR) and the corresponding 95 % confidence interval (CI).
Results
A total of 171,136 women were divided into the IM (n = 91,902) and CM (n = 79,234) groups. Among the 9,608,545 claims analyzed, respiratory system disease was the most common primary diagnosis, followed by genitourinary system diseases. In the IM group, 19,153 claims were associated with infertility diagnosis codes, with the most frequent primary diagnoses being female infertility associated with anovulation and female infertility of other origins. Compared with the CM group, the IM group had significantly greater rates of assisted reproductive technology (ART) use (aOR, 1.25 [95 % CI, 1.21, 1.29]; P < 0.0001) and cesarean delivery (aOR, 1.08 [95 % CI, 1.06, 1.11]; P < 0.0001).
Conclusion
The study findings support that dual health care system use is not associated with the health outcomes of women who gave birth. The findings are expected to be valuable for establishing national health and medical policies or promoting health care utilization for women who give birth in South Korea.
{"title":"Integrative medicine and perinatal outcomes among women giving birth: A national population-based study in South Korea","authors":"Seongju Kim , Jiae Choi , Hye Won Lee , Sunju Park","doi":"10.1016/j.imr.2025.101135","DOIUrl":"10.1016/j.imr.2025.101135","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to examine the effects of integrative medicine (IM) on perinatal outcomes and health care utilization in women who gave birth in Korea.</div></div><div><h3>Methods</h3><div>This study used National Health Insurance Sharing Service (NHISS) claims data and established a retrospective cohort of all women who gave birth in Korea from January to December 2021. The women were categorized into IM and conventional medicine (CM) groups according to the nature of their health institution visits before delivery. To assess the risk of adverse perinatal outcomes between the two groups, a logistic regression model was used to estimate the odds ratio (OR) and the corresponding 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>A total of 171,136 women were divided into the IM (<em>n</em> = 91,902) and CM (<em>n</em> = 79,234) groups. Among the 9,608,545 claims analyzed, respiratory system disease was the most common primary diagnosis, followed by genitourinary system diseases. In the IM group, 19,153 claims were associated with infertility diagnosis codes, with the most frequent primary diagnoses being female infertility associated with anovulation and female infertility of other origins. Compared with the CM group, the IM group had significantly greater rates of assisted reproductive technology (ART) use (aOR, 1.25 [95 % CI, 1.21, 1.29]; <em>P</em> < 0.0001) and cesarean delivery (aOR, 1.08 [95 % CI, 1.06, 1.11]; <em>P</em> < 0.0001)<del>.</del></div></div><div><h3>Conclusion</h3><div>The study findings support that dual health care system use is not associated with the health outcomes of women who gave birth. The findings are expected to be valuable for establishing national health and medical policies or promoting health care utilization for women who give birth in South Korea.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101135"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-01Epub Date: 2025-03-10DOI: 10.1016/j.imr.2025.101137
Xinyue Li , Hye Won Lee , Tianyi Zhou , Nicola Robinson , Xiao-Yang Mio Hu , Momir Dunjić , Fangfang Wang , Rong Zhang , Consensus Panel , Yuhang Zhu , Fan Qu
Background
Assisted reproductive technologies (ART) are being increasingly utilized for mitigating fertility problems. Nonpharmacological interventions of traditional Chinese medicine (TCM) are widely used as an adjunct to ART, which may improve the rate of pregnancy. Currently, no standard treatment guidelines or consensus are available for non-pharmacological interventions of TCM for patients undergoing ART. The aim of this study was to establish a consensus on the use of non-pharmacological TCM interventions during the ART treatment cycle.
Methods
This study utilized existing data and developed a consensus among a panel of experts on non-pharmacological interventions of TCM for ART. Through face-to-face or online contact, the listed recommendations were revised one by one, and a consensus was reached when >70 % of the experts agreed with the recommendation. The writing group of the expert panel then created the first draft of the expert consensus based on the discussion in the first round. The second round was held to reach a consensus on content improvements based on the opinions of the experts in the previous round.
Results
After the literature search, a total of 873 related articles were retrieved, and 59 studies were ultimately included according to the inclusion and exclusion criteria. After two rounds of the survey, a total of 24 experts from 18 Chinese provinces across China and five international experts from the United Kingdom, Korea, and Serbia provided vital insight and support for the formulation of this consensus. The consensus outlines eight non-pharmacological interventions for seven different stages of the ART cycle and three major complications during ART, involving 23 items of clinical practice recommendations.
Conclusions
Expert consensus provides a foundation for integrating non-pharmacological TCM interventions into clinical practice during ART. As more high-quality, large-scale, multicenter clinical trials are conducted, these recommendations may be refined and updated to better inform clinical guidelines and improve patient outcomes in ART.
{"title":"Non-pharmacological interventions involving traditional Chinese medicine for assisted reproductive technology: A group consensus","authors":"Xinyue Li , Hye Won Lee , Tianyi Zhou , Nicola Robinson , Xiao-Yang Mio Hu , Momir Dunjić , Fangfang Wang , Rong Zhang , Consensus Panel , Yuhang Zhu , Fan Qu","doi":"10.1016/j.imr.2025.101137","DOIUrl":"10.1016/j.imr.2025.101137","url":null,"abstract":"<div><h3>Background</h3><div>Assisted reproductive technologies (ART) are being increasingly utilized for mitigating fertility problems. Nonpharmacological interventions of traditional Chinese medicine (TCM) are widely used as an adjunct to ART, which may improve the rate of pregnancy. Currently, no standard treatment guidelines or consensus are available for non-pharmacological interventions of TCM for patients undergoing ART. The aim of this study was to establish a consensus on the use of non-pharmacological TCM interventions during the ART treatment cycle.</div></div><div><h3>Methods</h3><div>This study utilized existing data and developed a consensus among a panel of experts on non-pharmacological interventions of TCM for ART. Through face-to-face or online contact, the listed recommendations were revised one by one, and a consensus was reached when >70 % of the experts agreed with the recommendation. The writing group of the expert panel then created the first draft of the expert consensus based on the discussion in the first round. The second round was held to reach a consensus on content improvements based on the opinions of the experts in the previous round.</div></div><div><h3>Results</h3><div>After the literature search, a total of 873 related articles were retrieved, and 59 studies were ultimately included according to the inclusion and exclusion criteria. After two rounds of the survey, a total of 24 experts from 18 Chinese provinces across China and five international experts from the United Kingdom, Korea, and Serbia provided vital insight and support for the formulation of this consensus. The consensus outlines eight non-pharmacological interventions for seven different stages of the ART cycle and three major complications during ART, involving 23 items of clinical practice recommendations.</div></div><div><h3>Conclusions</h3><div>Expert consensus provides a foundation for integrating non-pharmacological TCM interventions into clinical practice during ART. As more high-quality, large-scale, multicenter clinical trials are conducted, these recommendations may be refined and updated to better inform clinical guidelines and improve patient outcomes in ART.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 2","pages":"Article 101137"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-12-27DOI: 10.1016/j.imr.2024.101119
Haiyin Hu , Hui Wang , Lin Ang , Menglong Shi , Xiaolei Wu , Chenyao Zhang , Mei Han , Shigang Liu , Kai Li , Junhua Zhang , Zhaochen Ji
Background
Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.
Methods
After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.
Results
PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.
Conclusions
Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.
{"title":"Patient-Focused Drug Development and Real World Study","authors":"Haiyin Hu , Hui Wang , Lin Ang , Menglong Shi , Xiaolei Wu , Chenyao Zhang , Mei Han , Shigang Liu , Kai Li , Junhua Zhang , Zhaochen Ji","doi":"10.1016/j.imr.2024.101119","DOIUrl":"10.1016/j.imr.2024.101119","url":null,"abstract":"<div><h3>Background</h3><div>Patient-focused drug development (PFDD) is an important direction in the field of medical research and is of great significance to the development of medicine. In recent years, PFDD and real-world study (RWS) have gained much interest, of which both have their advantages. This study aims to promote research methods innovation and optimize clinical research design and implementation.</div></div><div><h3>Methods</h3><div>After a brief introduction of PFDD and RWS, this review focused on the comparison of clinical trials of PFDD and RWS in terms of objectives, Population, Intervention, Comparator, Outcome (PICO) elements, research team members, data acquisition, and research key points, and clarified the feasibility and significance of “patient-focused RWS” research model.</div></div><div><h3>Results</h3><div>PFDD emphasized that patients’ needs as well as the willingness and satisfaction of patients should be considered throughout the whole research process and the patient experience data should be collected during the study development and drug use. RWS emphasized the facticity of research implementation environment and the breadth of patient sources, which concerned the problem of the extrapolation of study results, the clinical localization, and patient applicability of the target drug. However, there is a connection between both of the above. Both clinical trials of PFDD and RWS bring benefits to patients.</div></div><div><h3>Conclusions</h3><div>Combining PFDD idea and RWS research method to carry out new research will maximize the benefits for patients. The study model combining the PFDD concept with RWS can facilitate drug development and dissemination, which can be popularized and applied in various research areas. This study can innovate research methods and provide new ideas for future research.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101119"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-01-23DOI: 10.1016/j.imr.2025.101123
Kyeong Han Kim , Hyein Jeong , Gyeong Seo Lee , Seung-Hee Lee
Generative artificial intelligence (AI) is being applied in various areas such as education, clinical practice, and research within the medical field. This review explores the potential use of AI models in acupuncture practice education. Recent and relevant findings were searched from literature. Active research on the use of AI in acupuncture education, particularly in areas such as acupoint selection and acupuncture manipulation, is ongoing. Additionally, AI-powered educational tools are being developed in the field of traditional medicine. The development of AI-driven educational tools for acupuncture education holds significant potential to enhance the effectiveness and efficiency of traditional medicine education.
{"title":"Exploring the potential of acupuncture practice education using artificial intelligence","authors":"Kyeong Han Kim , Hyein Jeong , Gyeong Seo Lee , Seung-Hee Lee","doi":"10.1016/j.imr.2025.101123","DOIUrl":"10.1016/j.imr.2025.101123","url":null,"abstract":"<div><div>Generative artificial intelligence (AI) is being applied in various areas such as education, clinical practice, and research within the medical field. This review explores the potential use of AI models in acupuncture practice education. Recent and relevant findings were searched from literature. Active research on the use of AI in acupuncture education, particularly in areas such as acupoint selection and acupuncture manipulation, is ongoing. Additionally, AI-powered educational tools are being developed in the field of traditional medicine. The development of AI-driven educational tools for acupuncture education holds significant potential to enhance the effectiveness and efficiency of traditional medicine education.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101123"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-11-15DOI: 10.1016/j.imr.2024.101100
Mei Liu , Ke Deng , Mingqi Wang , Qiao He , Jiayue Xu , Guowei Li , Kang Zou , Xin Sun , Wen Wang
Routinely collected health data (RCD) are currently accelerating publications that evaluate the effectiveness and safety of medicines and medical devices. One of the fundamental steps in using these data is developing algorithms to identify health status that can be used for observational studies. However, the process and methodologies for identifying health status from RCD remain insufficiently understood. While most current methods rely on International Classification of Diseases (ICD) codes, they may not be universally applicable. Although machine learning methods hold promise for more accurately identifying the health status, they remain underutilized in RCD studies. To address these significant methodological gaps, we outline key steps and methodological considerations for identifying health statuses in observational studies using RCD. This review has the potential to boost the credibility of findings from observational studies that use RCD.
{"title":"Methods for identifying health status from routinely collected health data: An overview","authors":"Mei Liu , Ke Deng , Mingqi Wang , Qiao He , Jiayue Xu , Guowei Li , Kang Zou , Xin Sun , Wen Wang","doi":"10.1016/j.imr.2024.101100","DOIUrl":"10.1016/j.imr.2024.101100","url":null,"abstract":"<div><div>Routinely collected health data (RCD) are currently accelerating publications that evaluate the effectiveness and safety of medicines and medical devices. One of the fundamental steps in using these data is developing algorithms to identify health status that can be used for observational studies. However, the process and methodologies for identifying health status from RCD remain insufficiently understood. While most current methods rely on International Classification of Diseases (ICD) codes, they may not be universally applicable. Although machine learning methods hold promise for more accurately identifying the health status, they remain underutilized in RCD studies. To address these significant methodological gaps, we outline key steps and methodological considerations for identifying health statuses in observational studies using RCD. This review has the potential to boost the credibility of findings from observational studies that use RCD.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101100"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-11-15DOI: 10.1016/j.imr.2024.101099
Xinxing Li , Dae Young Kim , Yunho Sung , Donghyun Kim , Seohyun Ahn , Hyejung Shin , Nur Afiqah Binti Zulkifli , Ji-won Seo , Shu Jiang , Parivash Jamrasi , SoYoung Ahn , Jun Hyun Bae , HeeKyung Yeo , Hayoung Park , Wook Song
Background
Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.
Methods
Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, n = 36) or Placebo supplement group (PG, n = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, t-tests for group and within-group differences, and two-way ANOVA.
Results
In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state P = 0.021; oxidative stress index, resting state P = 0.020, end of exercise, P = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state P = 0.041) and oxidative stress index (resting state P = 0.018 and end of exercise P = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.
Conclusion
Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.
Trial registration
Clinical Research Information Service (CRIS): KCT0008731.
{"title":"Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial","authors":"Xinxing Li , Dae Young Kim , Yunho Sung , Donghyun Kim , Seohyun Ahn , Hyejung Shin , Nur Afiqah Binti Zulkifli , Ji-won Seo , Shu Jiang , Parivash Jamrasi , SoYoung Ahn , Jun Hyun Bae , HeeKyung Yeo , Hayoung Park , Wook Song","doi":"10.1016/j.imr.2024.101099","DOIUrl":"10.1016/j.imr.2024.101099","url":null,"abstract":"<div><h3>Background</h3><div>Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.</div></div><div><h3>Methods</h3><div>Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, <em>n</em> = 36) or Placebo supplement group (PG, <em>n</em> = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, <em>t</em>-tests for group and within-group differences, and two-way ANOVA.</div></div><div><h3>Results</h3><div>In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state <em>P</em> = 0.021; oxidative stress index, resting state <em>P</em> = 0.020, end of exercise, <em>P</em> = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state <em>P</em> = 0.041) and oxidative stress index (resting state <em>P</em> = 0.018 and end of exercise <em>P</em> = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.</div></div><div><h3>Conclusion</h3><div>Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS): KCT0008731.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101099"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-12-27DOI: 10.1016/j.imr.2024.101117
Ying He , Gui-yuan Li , Chun-zhi Tang , Li-ming Lu , Guang-yi Xiong , Yi Gao , Juan Tong , Guang-en Zhong
Background
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.
Method
A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.
Results
The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14th treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO2/kg%, VE%, VO2/HR%, VEmax, VE/VO2 and VE/VCO2 in the PE group improved, especially VO2/kg%, VE%, VEmax, VE/VO2 and VE/VCO2 were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.
Conclusion
Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.
Trial Registration
Chinese Clinical Trial Registry, ChiCTR1900028627.
{"title":"Comparing penetrating needles and non-penetrating needles with electrical stimulation combined with exercise training for relief of dyspnea and improving exercise tolerance in chronic obstructive pulmonary disease patients: A single-blind randomized controlled trial","authors":"Ying He , Gui-yuan Li , Chun-zhi Tang , Li-ming Lu , Guang-yi Xiong , Yi Gao , Juan Tong , Guang-en Zhong","doi":"10.1016/j.imr.2024.101117","DOIUrl":"10.1016/j.imr.2024.101117","url":null,"abstract":"<div><h3>Background</h3><div>Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation. The purpose of this study was to evaluate the effectiveness of penetrating needles with electrical stimulation combined with exercise training on relieving dyspnea and improving exercise tolerance among COPD patients.</div></div><div><h3>Method</h3><div>A total of 85 patients were recruited and randomly assigned to receive either penetrating needles with electrical stimulation (PE) or non-penetrating needles with electrical stimulation (NPE), 3 times a week, for 8 weeks, totaling 24 treatments. Both groups underwent exercise training. The evaluations were conducted at the baseline, after 14 treatments, and after 24 treatments.</div></div><div><h3>Results</h3><div>The PE group showed significant improvement in 6-minute walk distance (6MWD) after the 14<sup>th</sup> treatment. For pulmonary function test, MVV%, MEF50%, MEF75% and MEF25% improved in the PE group, especially MVV% was significantly higher than the NPE group. For cardiopulmonary exercise testing, METs%, VO<sub>2</sub>/kg%, V<sub>E</sub>%, VO<sub>2</sub>/HR%, V<sub>Emax</sub>, V<sub>E</sub>/VO<sub>2</sub> and V<sub>E</sub>/VCO<sub>2</sub> in the PE group improved, especially VO<sub>2</sub>/kg%, V<sub>E</sub>%, V<sub>Emax</sub>, V<sub>E</sub>/VO<sub>2</sub> and V<sub>E</sub>/VCO<sub>2</sub> were significantly higher than the NPE group. The scores of COPD assessment test in the PE group significantly improved. The scores of modified British Medical Research Council in the PE group was better than the NPE group after the treatment.</div></div><div><h3>Conclusion</h3><div>Penetrating needles with electrical stimulation combined with exercise training may be clinically useful for COPD patients in relieving dyspnea and improving exercise tolerance.</div></div><div><h3>Trial Registration</h3><div>Chinese Clinical Trial Registry, ChiCTR1900028627.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101117"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2024-11-14DOI: 10.1016/j.imr.2024.101101
Jeremy Y. Ng
Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.
{"title":"The case for data sharing in traditional, complementary, and integrative medicine research","authors":"Jeremy Y. Ng","doi":"10.1016/j.imr.2024.101101","DOIUrl":"10.1016/j.imr.2024.101101","url":null,"abstract":"<div><div>Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101101"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-01-10DOI: 10.1016/j.imr.2025.101122
Boram Lee , Chan-Young Kwon , Hye Won Lee , Arya Nielsen , L Susan Wieland , Tae-Hun Kim , Stephen Birch , Terje Alraek , Myeong Soo Lee
{"title":"Concerns about the use of verum acupuncture points in sham acupuncture studies for pain conditions: Findings and insights from network meta-analysis","authors":"Boram Lee , Chan-Young Kwon , Hye Won Lee , Arya Nielsen , L Susan Wieland , Tae-Hun Kim , Stephen Birch , Terje Alraek , Myeong Soo Lee","doi":"10.1016/j.imr.2025.101122","DOIUrl":"10.1016/j.imr.2025.101122","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101122"},"PeriodicalIF":2.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}