Integrative Medicine Research最新文献_第7页

What is integrative medicine? Establishing the decision criteria for an operational definition of integrative medicine for general practice health services research in Australia 什么是综合医学？制定澳大利亚全科医疗服务研究综合医学操作定义的决策标准

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-24 DOI: 10.1016/j.imr.2023.100995

Jennifer Hunter , Joanna E. Harnett , Wai-Jo Jocelin Chan , Marie Pirotta

Background

Operational definitions outline how a conceptual definition will be measured for consistent, reproducible data collection and analysis. This article reports the decision criteria that will be used for an operational definition of integrative medicine (IM) in a secondary analysis of an Australian national survey of general practitioner activity.

Methods

A multidisciplinary team applied an iterative approach, informed by expert knowledge and literature reviews to establish decision criteria for categorizing the terms in the Australian clinical interface terminology of the International Classification of Primary Care, second edition (ICPC-2 PLUS) and the Coding Atlas for Pharmaceutical Substances, according to whether they reflected IM, conventional/mainstream medicine (MM), or both IM and MM (IM/MM).

Results

The final decision criteria categorized all terms for examinations, investigations, advice/counselling, and drugs with synthetic ingredients, and terms for referrals to secondary care services and healthcare practitioners that are not a traditional or complementary medicine practitioner as MM. Terms that could apply to both styles of clinical practice (e.g., preventive health, lifestyle medicine, psychosocial and some drugs with natural ingredients) were categorised as IM/MM. The remaining terms, that mostly reflected the World Health Organization's theoretical definitions of traditional and complementary medicine, were categorized as IM.

Conclusion

Differentiating between integrative and conventional/mainstream medicine in general practice is context specific and not always possible. The category IM/MM proposes integrative medicine as an extension, rather than an alternative. The rationale for the integrative medicine operational definition has relevance for researchers and health services in Australia, and internationally.

背景操作定义概述了如何衡量概念定义，以进行一致、可重复的数据收集和分析。本文报告了在对澳大利亚全国全科医生活动调查的二次分析中，将用于综合医学（IM）操作定义的决策标准。方法一个多学科团队在专家知识和文献综述的基础上，采用迭代方法，根据是否反映IM，建立对《国际初级保健分类》第二版（ICPC-2 PLUS）和《药物编码图谱》中的术语进行分类的决策标准，传统/主流医学（MM）或IM和MM两者（IM/MM）。结果最终决定标准将所有检查、调查、咨询/咨询和含有合成成分的药物的术语，以及转诊至二级护理服务和非传统或补充医学从业者的医疗从业者的术语归类为MM。适用于两种类型临床实践的术语（例如，预防性健康、生活方式医学、心理社会和一些含有天然成分的药物）被归类为IM/MM。其余术语主要反映了世界卫生组织对传统医学和补充医学的理论定义，被归类为IM。结论在全科医学中区分综合医学和传统/主流医学是特定的，并不总是可能的。IM/MM类别建议将综合医学作为一种延伸，而不是一种替代。综合医学操作定义的基本原理与澳大利亚和国际上的研究人员和卫生服务部门有关。

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引用次数: 0

Curcumin, inflammation, and neurological disorders: How are they linked? 姜黄素、炎症和神经系统疾病:它们是如何联系在一起的?

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100968

Prachi Garodia , Mangala Hegde , Ajaikumar B. Kunnumakkara , Bharat B. Aggarwal

Background

Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases.

Methods

We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using ‘Curcumin and clinical trials’.

Results

This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed.

Conclusion

This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.

背景尽管近年来进行了广泛的研究，但目前神经系统疾病的治疗方式并不理想。姜黄素是一种在姜黄属中发现的多酚，已被证明可以减轻神经炎症和神经退行性疾病的病理生理学和临床后果。方法检索PubMed数据库中有关姜黄素及其在神经系统疾病治疗中的应用的相关文献。我们还回顾了PubMed数据库中使用“姜黄素和临床试验”搜索的相关临床试验。结果综述了姜黄素及其衍生物和制剂在各种临床前和临床研究中的多效性免疫调节功能和神经保护特性。姜黄素对神经退行性疾病的影响，如阿尔茨海默病（AD）、肌萎缩性侧索硬化症（ALS）、脑肿瘤、癫痫、亨廷顿舞蹈症（HD）、缺血、帕金森病（PD）、多发性硬化症（MS）和创伤性脑损伤（TBI），主要关注相关的信号通路，已经进行了深入的讨论。结论姜黄素可以通过调节星形胶质细胞介导的多种级联反应来抑制脊髓神经炎症，确保神经系统疾病的治疗。

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引用次数: 1

Moxibustion for medical personnel with negative emotion and insomnia during COVID-19 pandemic: A randomized, controlled trial 艾灸对新冠肺炎大流行期间消极情绪和失眠医务人员的影响:一项随机对照试验

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100974

Xiying Li , Xiaojuan Li , Xian Wang , Xuan Yin , Shanshan Li , Junyi Wu , Xiumei Ren , Wei Zhang , Yiqun Mi , Shifen Xu

Background

We conducted this randomized controlled trial (RCT) to evaluate the effectiveness and safety of moxibustion at Sanyinjiao (SP6) acupoint for treatment of negative mood and sleep quality in healthcare workers during the 2019 coronavirus disease (COVID-19).

Methods

A total of 180 participants were divided in a 1:1 ratio into two groups, the treatment group (for moxibustion) and the control group (for no treatment). The treatment group had a 30-minute moxibustion therapy once a day for two weeks, followed by a two-week follow-up. The Hamilton Anxiety Scale (HAMA) was used to assess the degree of the participants' anxiety, and the Patient Health Questionnaire-9 (PHQ-9) was utilized to examine their depressed condition. The Maslach Burnout Inventory-General Survey (MBI-GS) was used to measure the level of burnout among healthcare workers. To determine the severity of insomnia, the Sleep Dysfunction Rating Scale (SDRS) was utilized. At baseline, week 2, and week 4, all scales were evaluated.

Results

Compared to the control group, the treatment group improved more significantly in the HAMA at week 2 (MD = -19.01, 95% CI: -21.89 to -16.14; P<0.001) and at week 4 follow-up visits (MD = -8.96, 95% CI: -11.19 to -6.73; P<0.001). A subgroup study of HAMA scores revealed that position and education had significant impact on treatment effectiveness. During the 2-week intervention period, the treatment group showed more significant improvements in depressive symptoms measured by PHQ-9 (13.00±2.41 vs. 15.60±3.65; P<0.001), work burnout symptoms measured by MBI-GS (MD = -11.88, 95% CI, -15.73 to -8.03; P<0.001), and insomnia symptoms measured by SDRS (MD = -2.45, 95% CI, -4.24 to -0.66; P<0.01). There were no significant adverse effects reported.

Conclusion

Moxibustion at SP6 may be an effective treatment to improve anxiety, depression, sleep quality, and quality of life for healthcare workers during COVID-19.

Trial registration

This trial was registered at Chinese Clinical Trial Registry (ChiCTR): ChiCTR-2200059327.

背景我们进行了随机对照试验（RCT），以评估艾灸三阴交穴治疗2019冠状病毒病（新冠肺炎）期间医护人员负面情绪和睡眠质量的有效性和安全性。方法将180名受试者按1:1的比例分为两组，治疗组（艾灸）和对照组（不治疗）。治疗组采用30分钟艾灸疗法，每天一次，持续两周，随后进行为期两周的随访。汉密尔顿焦虑量表（HAMA）用于评估参与者的焦虑程度，患者健康问卷-9（PHQ-9）用于检查他们的抑郁状况。Maslach倦怠量表综合调查（MBI-GS）用于衡量医护人员的倦怠水平。为了确定失眠的严重程度，使用了睡眠功能障碍评定量表（SDRS）。在基线、第2周和第4周，对所有量表进行评估。结果与对照组相比，治疗组在第2周的HAMA改善更为显著（MD=-19.01，95%CI:21.89至-16.14；P<；0.001），在第4周的随访中（MD=-8.96，95%CI:11.19至-6.73；P<：0.001）。HAMA评分的亚组研究显示，职位和教育对治疗效果有显著影响。在2周的干预期内，治疗组在PHQ-9测量的抑郁症状（13.00±2.41 vs.15.60±3.65；P<；0.001）、MBI-GS测量的工作倦怠症状（MD=-11.88，95%CI，-15.73至-8.03；P<）、，通过SDRS测量失眠症状（MD=2.45，95%CI-4.24--0.66；P<；0.01）。没有显著的不良反应报告。结论艾灸SP6可能是改善COVID-19期间医护人员焦虑、抑郁、睡眠质量和生活质量的有效治疗方法。

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引用次数: 0

Acupuncture treatment for functional gastrointestinal disorders: Identification of major acupoints using network analysis 针刺治疗功能性胃肠疾病:用网络分析识别主要穴位

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100970

Heeyoung Moon , Yeonhee Ryu , In-Seon Lee , Younbyoung Chae

Background

Using network analysis, we sought to determine the acupoints most commonly used to treat functional gastrointestinal disorders (FGIDs), particularly functional dyspepsia (FD) and irritable bowel syndrome (IBS).

Methods

To explore the acupoint patterns used for FGID, data on acupoint combinations for FD and IBS were gathered from systematic reviews. Network analysis was used to determine the degree, closeness centrality, betweenness centrality, and eigenvector centrality of each acupoint. The most common acupoint combinations for FD and IBS were examined based on the eigenvector centrality.

Results

Network analysis revealed that CV12, ST25, ST36, CV10, and LR3, which had the highest eigenvector centrality values, were the main acupoints for treating FGID. CV12 was the main acupoint for treating FD, while ST25 was the hub acupoint for treating IBS in the abdomen. ST36, LR3, and PC6 were the key peripheral acupoints for FD and IBS.

Conclusions

Using network analysis, we provided data that will aid the selection of both general and specific acupoints for FD and IBS, along with spatial information (i.e., the positions of acupoints on a body map). These findings could be applied in future acupuncture research on therapy for gastrointestinal system dysfunction. They may also help bridge the gap between the traditional meridian theory, which assumes that there is a link between diseases/symptoms and the specific body region being treated, and real-world clinical evidence.

背景采用网络分析法，我们试图确定最常用于治疗功能性胃肠道疾病（FGID）的穴位，特别是功能性消化不良（FD）和肠易激综合征（IBS）。采用网络分析法确定各穴位的程度、接近中心性、介数中心性和特征向量中心性。根据特征向量中心性检查FD和IBS最常见的穴位组合。结果网络分析显示，CV12、ST25、ST36、CV10和LR3是治疗FGID的主要穴位，其特征向量中心值最高。CV12为治疗FD的主要穴位，ST25为治疗腹部IBS的中枢穴位。ST36、LR3和PC6是FD和IBS的关键外周穴位。结论通过网络分析，我们提供了有助于选择FD和IBS的一般和特定穴位的数据，以及空间信息（即穴位在身体图上的位置）。这些发现可应用于未来针灸治疗胃肠系统功能障碍的研究。它们还可能有助于弥合传统经络理论与现实世界临床证据之间的差距，传统经络理论假设疾病/症状与正在治疗的特定身体区域之间存在联系。

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引用次数: 0

Acupuncture as an alternative or in addition to conventional treatment for chronic non-specific low back pain: A systematic review and meta-analysis 针灸作为慢性非特异性腰痛常规治疗的替代或补充：一项系统综述和荟萃分析。

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100972

Carlo Maria Giovanardi , Marien Gonzalez-Lorenzo , Alessandra Poini , Eleonora Marchi , Antonio Culcasi , Francesco Ursini , Cesare Faldini , Alberto Di Martino , Umberto Mazzanti , Emanuela Campesato , Annunzio Matrà , Sabina Cevoli , Maria Grazia Benedetti

Background

Conventional therapies (CTs), pharmacological (PH) and non–pharmacological (NPH), do not always achieve benefits in the treatment of chronic low back pain (CLBP). We assessed efficacy and safety of acupuncture for CLBP as alternative or addition to CT.

Methods

We included randomised controlled trials (RCTs) comparing acupuncture alone or in combination with CT to CT. We searched Medline, Cochrane Library, Embase up to May 2022. We assessed risk of bias with the original Cochrane tool and GRADE certainty of evidence. Results were pooled through meta-analysis.

Results

Ten RCTs (2122 participants) were included comparing acupuncture versus CT and 4 RCTs (374 participants) were comparing acupuncture plus CT to CT alone. In terms of comparing acupuncture with NPH or PH, no differences were found for pain and disability. Comparing acupuncture with PH and NPH combined, pain and disability were reduced (SMD=-0.50, 95% CI -0.62 to -0.37; SMD=-0.71, 95% CI -1.17 to -0.24). Comparing acupuncture plus NPH with NPH alone, pain and disability were reduced (SMD=-0.70, 95% CI -0.94 to -0.46; SMD=-0.95, 95% CI -1.36 to -0.54). Comparing acupuncture plus PH with PH alone, pain and disability were reduced (MD=-0.21, 95% CI -433.28 to -10.42; MD=-3.1, 95% CI -4.87 to -1.83). Comparing acupuncture plus combined treatment versus combined treatment alone, no differences were found in pain, while disability was reduced (MD=-3.40 95% CI -5.17 to -1.63). No studies assessed adverse event. Certainty of evidence ranged from moderate to very low.

Conclusions

We are uncertain whether acupuncture is more effective and safer than CT. In the comparisons without estimates’ imprecision, acupuncture showed promising results. Acupuncture could be an option based on patients’ preferences.

背景：常规疗法（CT）、药理学（PH）和非药理学（NPH）在治疗慢性腰痛（CLBP）方面并不总是有效。我们评估了针灸作为CT的替代或补充治疗CLBP的疗效和安全性。方法：我们纳入了随机对照试验（RCT），将单独或联合针灸与CT进行比较。我们搜索了Medline、Cochrane Library、Embase，直到2022年5月。我们使用原始的Cochrane工具和GRADE证据确定性评估了偏倚的风险。结果：10项随机对照试验（2122名参与者）比较了针灸与CT，4项随机对照研究（374名参与者）将针灸加CT与单独CT进行了比较。就针灸与NPH或PH的比较而言，在疼痛和残疾方面没有发现差异。针刺与PH和NPH联合治疗相比，疼痛和残疾减轻（SMD=-0.50，95%CI-0.62至-0.37；SMD=-0.71，95%CI-1.17至-0.24）。针刺与NPH联合用药与单独用药相比，痛苦和残疾减轻了（SMD=-0.70，95%CI-0.94至-0.46；SMD=-0.55，95%CI-1.36至-0.54），疼痛和残疾减轻（MD=-0.21，95%CI-433.28至-10.42；MD=-3.1，95%CI-4.87至-1.83）。比较针灸联合治疗和单独联合治疗，疼痛没有差异，残疾减轻（MD=-3.40，95%CI-5.17至-1.63）。没有研究评估不良事件。证据的确定性从中等到极低不等。结论：我们不确定针灸是否比CT更有效、更安全。在没有估计不精确的比较中，针灸显示出有希望的结果。针灸可以根据患者的喜好进行选择。

{"title":"Acupuncture as an alternative or in addition to conventional treatment for chronic non-specific low back pain: A systematic review and meta-analysis","authors":"Carlo Maria Giovanardi , Marien Gonzalez-Lorenzo , Alessandra Poini , Eleonora Marchi , Antonio Culcasi , Francesco Ursini , Cesare Faldini , Alberto Di Martino , Umberto Mazzanti , Emanuela Campesato , Annunzio Matrà , Sabina Cevoli , Maria Grazia Benedetti","doi":"10.1016/j.imr.2023.100972","DOIUrl":"10.1016/j.imr.2023.100972","url":null,"abstract":"<div><h3>Background</h3><p>Conventional therapies (CTs), pharmacological (PH) and non–pharmacological (NPH), do not always achieve benefits in the treatment of chronic low back pain (CLBP). We assessed efficacy and safety of acupuncture for CLBP as alternative or addition to CT.</p></div><div><h3>Methods</h3><p>We included randomised controlled trials (RCTs) comparing acupuncture alone or in combination with CT to CT. We searched Medline, Cochrane Library, Embase up to May 2022. We assessed risk of bias with the original Cochrane tool and GRADE certainty of evidence. Results were pooled through meta-analysis.</p></div><div><h3>Results</h3><p>Ten RCTs (2122 participants) were included comparing acupuncture versus CT and 4 RCTs (374 participants) were comparing acupuncture plus CT to CT alone. In terms of comparing acupuncture with NPH or PH, no differences were found for pain and disability. Comparing acupuncture with PH and NPH combined, pain and disability were reduced (SMD=-0.50, 95% CI -0.62 to -0.37; SMD=-0.71, 95% CI -1.17 to -0.24). Comparing acupuncture plus NPH with NPH alone, pain and disability were reduced (SMD=-0.70, 95% CI -0.94 to -0.46; SMD=-0.95, 95% CI -1.36 to -0.54). Comparing acupuncture plus PH with PH alone, pain and disability were reduced (MD=-0.21, 95% CI -433.28 to -10.42; MD=-3.1, 95% CI -4.87 to -1.83). Comparing acupuncture plus combined treatment versus combined treatment alone, no differences were found in pain, while disability was reduced (MD=-3.40 95% CI -5.17 to -1.63). No studies assessed adverse event. Certainty of evidence ranged from moderate to very low.</p></div><div><h3>Conclusions</h3><p>We are uncertain whether acupuncture is more effective and safer than CT. In the comparisons without estimates’ imprecision, acupuncture showed promising results. Acupuncture could be an option based on patients’ preferences.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100972"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/d0/main.PMC10448023.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Patient preferences and shared decision making for the traditional Chinese medicine treatment of lung cancer: A discrete choice experiment study 肺癌中医治疗的患者偏好与共同决策:离散选择实验研究

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100969

Yue Teng , Yan Wei , Yingyao Chen , Juntao Yan , Shimeng Liu , Fuming Li , Shiyi Bao , Yanfeng Ren , Liu Liu , Yi Yang

Background

Traditional Chinese Medicine (TCM), integrating patient preferences into decision-making process, has been widely used in the multimodality therapy of lung cancer. This study aimed to estimate patient preferences for treatment and shared decision-making (SDM) modes concerning inpatient TCM treatment of lung cancer in Shanghai in order to provide a basis for clinical decision-making process on TCM therapy for lung cancer.

Methods

This study was conducted among patients (n = 347) from nine tertiary hospitals in Shanghai by discrete-choice experiment (DCE) survey and Shared Decision-Making Questionnaire-patient version (SDM-Q-9) survey. The DCE was developed with the inclusion of the most relevant attributes at appropriate levels for the TCM treatment of lung cancer. The empirical data analyses of patients were performed using mixed logit models. Additionally, subgroup analysis was conducted.

Results

In total, 347 respondents completed the questionnaire. All attributes’ coefficients were statistically significant for patients’ preferences. Patients showed strong preferences for increasing disease control rate, relieving nausea and vomiting, reducing the risk of side effects, and were concerned about monthly out-of-pocket costs. Subgroup analysis indicated that patients with a lower SDM-Q-9 score and those who were satisfied with medical services emphasized more importance of higher disease control rate. Furthermore, most of the patients (90.20%) self-reported a high willingness to use SDM during the decision-making process.

Conclusion

In Shanghai, patients mainly preferred SDM and considered disease control rate as the most essential attribute in the TCM treatment of lung cancer. The study findings could underscore the importance of considering patients’ preferences and promote SDM.

背景中医将患者的喜好融入决策过程，已广泛应用于癌症的多模式治疗。本研究旨在评估上海市癌症住院中医治疗的患者治疗偏好和共享决策模式，为癌症中医治疗的临床决策过程提供依据。方法采用离散选择实验（DCE）和共享决策问卷（SDM-Q-9）两种方法对上海市9所三甲医院347名患者进行问卷调查。DCE的开发包含了在适当水平上对癌症的中医治疗最相关的属性。使用混合logit模型对患者进行实证数据分析。此外，还进行了亚组分析。结果共有347名被调查者完成了问卷调查。所有属性的系数对患者的偏好具有统计学意义。患者对提高疾病控制率、缓解恶心和呕吐、降低副作用风险表现出强烈的偏好，并担心每月的自付费用。亚组分析表明，SDM-Q-9评分较低的患者和对医疗服务满意的患者更强调疾病控制率较高的重要性。此外，大多数患者（90.20%）自我报告在决策过程中使用SDM的意愿很高。结论上海地区患者以SDM为主，疾病控制率是癌症中医治疗最基本的指标。研究结果可以强调考虑患者偏好和促进SDM的重要性。

{"title":"Patient preferences and shared decision making for the traditional Chinese medicine treatment of lung cancer: A discrete choice experiment study","authors":"Yue Teng , Yan Wei , Yingyao Chen , Juntao Yan , Shimeng Liu , Fuming Li , Shiyi Bao , Yanfeng Ren , Liu Liu , Yi Yang","doi":"10.1016/j.imr.2023.100969","DOIUrl":"10.1016/j.imr.2023.100969","url":null,"abstract":"<div><h3>Background</h3><p>Traditional Chinese Medicine (TCM), integrating patient preferences into decision-making process, has been widely used in the multimodality therapy of lung cancer. This study aimed to estimate patient preferences for treatment and shared decision-making (SDM) modes concerning inpatient TCM treatment of lung cancer in Shanghai in order to provide a basis for clinical decision-making process on TCM therapy for lung cancer.</p></div><div><h3>Methods</h3><p>This study was conducted among patients (<em>n</em> = 347) from nine tertiary hospitals in Shanghai by discrete-choice experiment (DCE) survey and Shared Decision-Making Questionnaire-patient version (SDM-Q-9) survey. The DCE was developed with the inclusion of the most relevant attributes at appropriate levels for the TCM treatment of lung cancer. The empirical data analyses of patients were performed using mixed logit models. Additionally, subgroup analysis was conducted.</p></div><div><h3>Results</h3><p>In total, 347 respondents completed the questionnaire. All attributes’ coefficients were statistically significant for patients’ preferences. Patients showed strong preferences for increasing disease control rate, relieving nausea and vomiting, reducing the risk of side effects, and were concerned about monthly out-of-pocket costs. Subgroup analysis indicated that patients with a lower SDM-Q-9 score and those who were satisfied with medical services emphasized more importance of higher disease control rate. Furthermore, most of the patients (90.20%) self-reported a high willingness to use SDM during the decision-making process.</p></div><div><h3>Conclusion</h3><p>In Shanghai, patients mainly preferred SDM and considered disease control rate as the most essential attribute in the TCM treatment of lung cancer. The study findings could underscore the importance of considering patients’ preferences and promote SDM.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"12 3","pages":"Article 100969"},"PeriodicalIF":3.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/f2/main.PMC10400851.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100976

Lu Ding , Cui Li , Peiming Zhang , Chen Chen , Jie Zhan , Jinchun Zeng , Liming Lu

Background

An increasing amount of clinical evidence of acupuncture's effect on protracted opioid abstinence syndrome (POAS) has emerged in recent years. The aim of this study was to evaluating the evidence of efficacy of acupuncture for POAS. clinical and scientific research work.

Methods

Four English-language databases (PubMed, Medline, Embase, Cochrane Libraries) and three Chinese-language databases (CNKI, WanFang and VIP Libraries) were searched, with coverage from database inception to March 31, 2022. Randomized clinical trials (RCTs) evaluating the effects of acupuncture and acupuncture-related therapies for prophylaxis or treatment of POAS were included. Data were screened and extracted independently according to pre-set tabular formats. RCT quality was assessed using risk of bias tool in the Cochrane Collaboration. The primary outcome was opiate withdrawal scale. The secondary outcomes are depression, anxiety for assessing protracted symptoms. The scores on the above scales are proportional to the severity of the symptoms.

Results

Twenty-eight trials met the inclusion criteria and provided data for the meta-analysis. A total of only 3 studies (11%) were judged to be low-risk overall due to various biases in them. Acupuncture-related therapy showed statistical differences in improving protracted withdrawal symptom scores compared with sham acupuncture (5 studies, Standard mean difference (SMD), -1.85, 95% CI [-3.21, -0.50], P = 0.007), western medicine (7 studies, SMD, -0.72, 95% CI [-1.22, -0.21], P = 0.005) and no treatment (3 studies, SMD,-2.26, 95% CI [-3.82, -0.69], P = 0.005) with high heterogeneity.

Conclusions

Acupuncture maybe safe and effective in relieving POAS individuals’ protracted withdrawal symptoms. However, the results of our review should be interpreted with caution because of the high risk of bias of the included trials.

Study registration

The protocol of this review has been registered at PROSPERO (CRD42022335505).

背景近年来，越来越多的临床证据表明针灸治疗阿片类药物长期戒断综合征（POAS）。本研究的目的是评估针灸治疗POAS的疗效证据。临床和科研工作。方法检索4个英文数据库（PubMed、Medline、Embase、Cochrane Libraries）和3个中文数据库（CNKI、WanFang和VIP Libraries。随机临床试验（RCT）评估了针灸和针灸相关疗法预防或治疗POAS的效果。根据预设的表格格式对数据进行独立筛选和提取。使用Cochrane协作中的偏倚风险工具评估随机对照试验的质量。主要结果是阿片类药物戒断量表。次要结果是抑郁，评估长期症状的焦虑。上述量表上的分数与症状的严重程度成正比。结果28项试验符合纳入标准，为荟萃分析提供了数据。由于存在各种偏见，总共只有3项研究（11%）被判定为总体低风险。与假针灸相比，针灸相关治疗在改善长期戒断症状评分方面显示出统计学差异（5项研究，标准平均差（SMD），-1.85，95%CI[3.21，-0.50]，P=0.007），西药（7项研究，SMD，-0.72，95%CI[1.22，-0.21]，P=0.005）和无治疗（3项研究，SMT，-2.26，95%CI[3.82，-0.69]，P=0.0005）具有高度异质性。结论针刺对缓解POAS患者的长期戒断症状可能是安全有效的。然而，我们的审查结果应谨慎解读，因为纳入的试验存在较高的偏倚风险。研究注册本次审查的方案已在PROSPERO注册（CRD42022335505）。

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引用次数: 0

AI Chat bot - ChatGPT-4: A new opportunity and challenges in complementary and alternative medicine AI聊天机器人-ChatGPT-4：补充和替代医学的新机遇和挑战

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100977

Tae-Hun Kim , Jung Won Kang , Myeong Soo Lee

引用次数: 0

Efficacy and safety of herbal medicine (Binafuxi granules) for the common cold with fever: A multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial 宾纳福喜颗粒治疗普通感冒发热的疗效和安全性:一项多中心、随机、双盲、安慰剂对照的II期临床试验

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100956

Xuemei Liu , Jie Min , Bin She , Yan Chen , Jun Li , Lei Huang , Ju Chen , Ai Luo , Mei Yang , Ting Li , Yanqing Wu , Daohong Chen , Hongli Zhong , Wei Liu , Bing Mao , Hongli Jiang

Background

Binafuxi granules are a traditional Uighur medicine (TUM) for treating the common cold with fever. However, high-quality clinical studies supporting its efficacy and safety are lacking.

Methods

In this multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial, patients with common cold and fever were randomly assigned to a high-dose group, low-dose group, and placebo group in a 1:1:1 ratio. Outcomes were time to fever relief, time to fever clearance, proportion of afebrile patients, time to symptom disappearance, rate of symptom disappearance, effective rate, emergency drug usage and safety assessment.

Results

A total of 235 patients were recruited. Of these, 234 were included in the full analysis set (FAS), and 217 were included in the per-protocol set (PPS). In the FAS analysis, the median time to fever relief was 6.00 h, 5.54 h and 10.65 h (P = 0.31) in the high-dose group, low-dose group and placebo group, respectively. The median time to fever clearance was 18.29 h, 20.08 h and 25.00 h (P = 0.0018), respectively, and the proportion of afebrile patients was 92.4%, 89.7% and 71.4% (P = 0.0002), respectively. There was a significant difference in the disappearance time and disappearance rate of all symptoms and of individual symptoms. No serious adverse events were found.

Conclusions

Binafuxi granules can dose-dependently shorten the fever course and improve clinical symptoms in patients suffering from the common cold with fever.

Trial Registration

This trial was registered at Chinese Clinical Trial Registry (ChiCTR-IIR-17013379).

背景必那福喜颗粒是一种治疗普通感冒伴发热的维吾尔族传统药物。然而，缺乏支持其疗效和安全性的高质量临床研究。方法在这项多中心、随机、双盲、安慰剂对照的II期临床试验中，将普通感冒和发烧患者按1:1:1的比例随机分为高剂量组、低剂量组和安慰剂组。结果包括退烧时间、退热时间、无热患者比例、症状消失时间、症状消失率、有效率、紧急用药和安全性评估。结果共招募235名患者。其中，234项纳入完整分析集（FAS），217项纳入按方案集（PPS）。在FAS分析中，高剂量组、低剂量组和安慰剂组的中位退烧时间分别为6.00小时、5.54小时和10.65小时（P=0.31）。发热消退的中位时间分别为18.29小时、20.08小时和25.00小时（P=0.0018），无热患者的比例分别为92.4%、89.7%和71.4%（P=0.0002）。所有症状和个别症状的消失时间和消失率存在显著差异。未发现严重不良事件。结论必复喜颗粒能剂量依赖性地缩短普通感冒伴发热患者的发热病程，改善临床症状。试验注册本试验在中国临床试验注册中心（ChiCTR-IIR-17013379）注册。

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引用次数: 0

Thread-embedding acupuncture may improve symptom resolution in patients with gastroesophageal reflux disease: A randomized controlled trial 埋线针刺可改善胃食管反流病患者的症状缓解:一项随机对照试验

IF 3.4 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2023-09-01 DOI: 10.1016/j.imr.2023.100971

Dieu-Thuong Thi Trinh , An Hoa Tran , Minh-Man Pham Bui , Nguyen Lam Vuong

Background

Various traditional medicine treatments have been investigated to treat GERD. Among those, thread-embedding acupuncture (TEA) has the advantage that patients need to undergo the procedure infrequently; however, its efficacy is unclear. This study evaluated the efficacy of TEA in treating GERD.

Methods

A randomized controlled trial was conducted with 66 participants with GERD: 33 received two sessions of TEA + standard therapy (proton-pump inhibitor [PPI]) (TEA+PPI group) and 33 received PPI alone (PPI group). Primary outcomes included GerdQ score and heartburn and regurgitation resolution. Secondary outcomes were antacids requirement, the Frequency Scale for Symptoms of GERD (FSSG) score, and Gastroesophageal Reflux Disease-Health Related Quality of Life (GERD-HRQL) score. The safety outcome was adverse events (AEs).

Results

After four weeks of treatment, the TEA+PPI group significantly reduced the GerdQ score (mean difference [MD] and 95% confidence interval [CI]: -1.8 [-2.4, -1.1]) and increased the rate of heartburn and regurgitation resolution compared to PPI (54.5% versus 9.1%, respectively) compared to PPI. The TEA+PPI group also significantly reduced the number of antacid packs used (MD [95%-CI]: -9.4 [-12.1, -6.7]), FSSG score (MD [95%-CI]: -9.4 [-11.0, -7.8]), and GERD-HRQL score (MD [95%-CI]: -5.6 [-7.7, -3.5]) compared to PPI. Five patients experienced AEs, which were mild local complications at the acupoints.

Conclusion

TEA combined with PPI is more effective than PPI alone in treating GERD. Further studies with longer follow-ups are required to confirm these findings.

Clinical trials registration information

This study was registered at ClinicalTrials.gov, NCT05353933.

背景研究了多种传统药物治疗胃食管反流病的方法。其中，线埋针灸（TEA）的优点是患者不需要经常进行手术；然而，其疗效尚不清楚。本研究评估了TEA治疗GERD的疗效。方法对66名GERD患者进行了随机对照试验：33人接受两次TEA+标准治疗（质子泵抑制剂[PPI]）（TEA+PPI组），33人单独接受PPI（PPI组）。主要结果包括GerdQ评分、烧心和反流消退。次要结果是抗酸剂需求、胃食管反流病症状频率量表（FSSG）评分和胃食管反流病健康相关生活质量（GERD-HRQL）评分。安全性结果为不良事件（AE）。结果治疗4周后，TEA+PPI组显著降低了GerdQ评分（平均差[MD]和95%置信区间[CI]：-1.8[-2.4，-1.1]），并与PPI相比增加了烧心率和反流消退率（分别为54.5%和9.1%）。与PPI相比，TEA+PPI组还显著减少了抗酸包的使用次数（MD[95%-CI]:-9.4[-12.1，-6.7]）、FSSG评分（MD[90%-CI]:-9.4[-11.0，-7.8]）和GERD-HRQL评分（MD-95%-CI]:-5.6[-7.7，-3.5]）。5例患者出现AE，为轻微的穴位局部并发症。结论TEA联合PPI治疗GERD疗效优于单纯PPI。需要进一步的研究和更长的随访来证实这些发现。临床试验注册信息本研究注册于ClinicalTrials.gov，NCT05353933。

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引用次数: 1