Integrative Medicine Research最新文献

{"title":"Acupuncture for acute ischemic stroke: A systematic review and meta-analysis of randomized controlled trials","authors":"Shanshan Huang ,&nbsp;Yuting Wang ,&nbsp;Yifan Wu ,&nbsp;Puchen Huang ,&nbsp;Yu Dong ,&nbsp;Qiao Zhang ,&nbsp;Mengjiao Zhao ,&nbsp;Jingchun Zeng ,&nbsp;Liming Lu ,&nbsp;Xinxia Liu","doi":"10.1016/j.imr.2024.101092","DOIUrl":"10.1016/j.imr.2024.101092","url":null,"abstract":"<div><h3>Objective</h3><div>Assess the safety and effectiveness of acupuncture for acute ischemic stroke (AIS).</div></div><div><h3>Methods</h3><div>We conducted a comprehensive search across the PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang, and SinoMed databases from their inception until October 3, 2023. Two reviewers screened eligible randomized controlled trials (RCTs) according to criteria and extracted data using a pre-established form. Cochrane tool was used for risk of bias assessment, and Revman 5.3 was used for subsequent meta-analysis. The GRADE tool will be used to assess the quality of evidence.</div></div><div><h3>Results</h3><div>Thirty-one RCTs were included, involving 3604 patients. Meta-analysis showed that compared with conventional treatments (CTs), acupuncture combined with CTs could improve in National Institutes of Health Stroke Scale (NIHSS) and Efficiency (MD:1.70, 95 %CI [-2.27, -1.14], <em>P</em> &lt; 0.00001;RR: 1.21, 95 %CI [1.12, 1.31], <em>P</em> &lt; 0.00001,);On the Chinese Stroke Scale (CSS) and effectiveness based on CSS, acupuncture showed positive effects (MD:4.33, 95 %CI [-5.67, -2.98], <em>P</em> &lt; 0.00001; RR: 1.26, 95 %CI [1.13, 1.41], <em>P</em> &lt; 0.0001). Furthermore, ADL, Fugl-Meyer Assessment Scale (FMA), prognosis analyses also showed the effectiveness of acupuncture. (SMD: 0.98, 95 % CI [0.64, 1.31], <em>P</em> &lt; 0.00001; MD: 16.46, 95 %CI [12.56, 20.35], <em>P</em> &lt; 0.00001; RR: 0.38, 95 %CI [0.16, 0.89], <em>P</em> = 0.03). However, the certainty of evidence was low.</div></div><div><h3>Conclusion</h3><div>According to current evidence, Acupuncture may be effective and safe for AIS. The future still needs high-quality evidence to support this conclusion.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101092"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of combined treatment with herbal medicines and palliative chemotherapy for advanced gastric cancer: A systematic review, and meta-analysis","authors":"Dong-Hyeon Kim ,&nbsp;Soo-Dam Kim ,&nbsp;Hyeong-Joon Jun ,&nbsp;Eun-Bin Kwag ,&nbsp;Sang-Won Shin ,&nbsp;Hwa-Seung Yoo ,&nbsp;So-Jung Park","doi":"10.1016/j.imr.2024.101098","DOIUrl":"10.1016/j.imr.2024.101098","url":null,"abstract":"<div><h3>Background</h3><div>Advanced gastric cancer (AGC) is a leading cause of cancer-related deaths worldwide, with its treatment complicated by challenges such as high recurrence rates, severe side effects, and limited effectiveness of current therapies. Herbal medicine (HM) has emerged as an adjunct to palliative chemotherapy (PC), potentially improving tumor response and reducing side effects. This study conducted a meta-analysis to evaluate the effectiveness and safety of HM in palliative therapy for inoperable stage Ⅲ and Ⅳ AGC patients.</div></div><div><h3>Methods</h3><div>Databases were searched until August 2023, encompassing 10 electronic databases, including PubMed, Embase, Cochrane Library, CNKI, and ScienceON. The inclusion criteria focused on randomized controlled trials (RCTs) combining herbal medicine with palliative therapy for patients with AGC. Primary outcomes assessed were tumor response rates, overall survival, adverse drug reactions (ADRs), and patients' quality of life (QoL).</div></div><div><h3>Results</h3><div>In our analysis of 101 RCTs comparing PC alone to PC combined with HM, the meta-analysis demonstrated statistically significant improvements in overall response rate (ORR), disease control rate (DCR), survival rates, as well as a reduction in adverse drug reactions (ADRs) and an enhancement in quality of life (QoL) for patients receiving HM in combination with PC (<em>p</em> &lt; 0.00001, I² = 0 %).</div></div><div><h3>Conclusion</h3><div>The combination of HM with PC significantly enhances tumor response and survival rates while reducing overall adverse drug reactions (ADRs) and improving quality of life (QoL) in patients with stage Ⅲ and Ⅳ AGC. HMs not only improve the efficacy of PC but also help alleviate side effects, including myelosuppression, digestive symptoms, nausea, vomiting, diarrhea, liver and renal injuries, and neurotoxicity.</div><div>Protocol registration: PROSPERO, CRD 42022354133.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101098"},"PeriodicalIF":2.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143142876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 8-week Theracurmin Super (TS-P1; Curcumin) supplementation on exercise-induced oxidative stress: A randomised, double-blind, placebo-controlled parallel clinical trial","authors":"Xinxing Li ,&nbsp;Dae Young Kim ,&nbsp;Yunho Sung ,&nbsp;Donghyun Kim ,&nbsp;Seohyun Ahn ,&nbsp;Hyejung Shin ,&nbsp;Nur Afiqah Binti Zulkifli ,&nbsp;Ji-won Seo ,&nbsp;Shu Jiang ,&nbsp;Parivash Jamrasi ,&nbsp;SoYoung Ahn ,&nbsp;Jun Hyun Bae ,&nbsp;HeeKyung Yeo ,&nbsp;Hayoung Park ,&nbsp;Wook Song","doi":"10.1016/j.imr.2024.101099","DOIUrl":"10.1016/j.imr.2024.101099","url":null,"abstract":"<div><h3>Background</h3><div>Given curcumin's antioxidant properties, this study aimed to determine the effectiveness and safety of Theracurmin Super supplementation in mitigating exercise-induced oxidative stress in healthy adults.</div></div><div><h3>Methods</h3><div>Seventy-one healthy adults participated in this study, which was conducted at Seoul National University from April 2022 to March 2023. Eligibility was determined during visit 1 through maximum oxygen consumption assessed using the Bruce Treadmill protocol. In visit 2, participants were randomly allocated to either the Theracurmin Super supplement group (TG, <em>n</em> = 36) or Placebo supplement group (PG, <em>n</em> = 35). Over 8 weeks, participants consumed Theracurmin Super (curcumin, 120 mg/day) or Placebo (curcumin, 0 mg/day) twice daily and visited the laboratory four times. Various parameters, including body composition, vital signs, nutrition quotient for adults, cardiorespiratory endurance, blood biomarkers, and adverse events, were assessed at each visit. Statistical analyses included per-protocol analysis, <em>t</em>-tests for group and within-group differences, and two-way ANOVA.</div></div><div><h3>Results</h3><div>In week 8, blood biomarkers linked to oxidative stress, including TBARs, MDA, 8-OHdG, SOD, TOS, and OSI, showed significant group- and week-related interactions (total oxidant status: resting state <em>P</em> = 0.021; oxidative stress index, resting state <em>P</em> = 0.020, end of exercise, <em>P</em> = 0.013). Notably, the TG showed a significant decrease in total oxidant status (resting state <em>P</em> = 0.041) and oxidative stress index (resting state <em>P</em> = 0.018 and end of exercise <em>P</em> = 0.008) between weeks 0 and 8. However, MDA and 8-OHdG levels did not show statistically significant changes.</div></div><div><h3>Conclusion</h3><div>Theracurmin Super effectively reduced oxidative stress before and after exercise, highlighting curcumin's promising role in managing oxidative stress. Significant improvements in TOS and OSI were observed, although changes in MDA and 8-OHdG levels were not statistically significant. Further research could provide insights into these mixed results across different oxidative biomarkers.</div></div><div><h3>Trial registration</h3><div>Clinical Research Information Service (CRIS): KCT0008731.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101099"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for identifying health status from routinely collected health data: An overview","authors":"Mei Liu ,&nbsp;Ke Deng ,&nbsp;Mingqi Wang ,&nbsp;Qiao He ,&nbsp;Jiayue Xu ,&nbsp;Guowei Li ,&nbsp;Kang Zou ,&nbsp;Xin Sun ,&nbsp;Wen Wang","doi":"10.1016/j.imr.2024.101100","DOIUrl":"10.1016/j.imr.2024.101100","url":null,"abstract":"<div><div>Routinely collected health data (RCD) are currently accelerating publications that evaluate the effectiveness and safety of medicines and medical devices. One of the fundamental steps in using these data is developing algorithms to identify health status that can be used for observational studies. However, the process and methodologies for identifying health status from RCD remain insufficiently understood. While most current methods rely on International Classification of Diseases (ICD) codes, they may not be universally applicable. Although machine learning methods hold promise for more accurately identifying the health status, they remain underutilized in RCD studies. To address these significant methodological gaps, we outline key steps and methodological considerations for identifying health statuses in observational studies using RCD. This review has the potential to boost the credibility of findings from observational studies that use RCD.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101100"},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The case for data sharing in traditional, complementary, and integrative medicine research","authors":"Jeremy Y. Ng","doi":"10.1016/j.imr.2024.101101","DOIUrl":"10.1016/j.imr.2024.101101","url":null,"abstract":"<div><div>Traditional, complementary, and integrative medicine (TCIM) research encompasses a diverse range of health practices rooted in various cultural, philosophical, and historical frameworks. As global interest in conducting research in this field grows, the need for rigorous research to support the integration of evidence-based TCIM therapies into mainstream healthcare has become essential. Data sharing is critical to advancing TCIM research by enhancing reproducibility, fostering interdisciplinary collaboration, promoting ethical practices, and addressing global health challenges. Despite its benefits, numerous challenges are associated with data sharing in TCIM, including a lack of standardized practices, cultural sensitivity, intellectual property concerns, and technical barriers in resource-limited settings. This editorial explores the unique nature of TCIM research, emphasizing the importance of data sharing while acknowledging the complexities it entails. Implementing the CARE Principles for Indigenous Data Governance, which prioritize collective benefit, authority to control, responsibility, and ethics, offers a framework for ensuring that data sharing respects indigenous knowledge and cultural sensitivities. Strategies for overcoming barriers to data sharing include developing standardized protocols, investing in research infrastructure, and fostering a culture of openness and collaboration within the TCIM community and beyond. By advancing data sharing practices, TCIM research can contribute to evidence-based healthcare solutions and address global health disparities, ultimately improving health outcomes worldwide.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 1","pages":"Article 101101"},"PeriodicalIF":2.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of electroacupuncture on internal carotid artery blood flow in patients undergoing laparoscopic gallbladder surgery: A randomized clinical trial","authors":"Lili Hu ,&nbsp;Yongyan Zhang ,&nbsp;Ying Li ,&nbsp;Ruiping Wang ,&nbsp;Hua Xu","doi":"10.1016/j.imr.2024.101097","DOIUrl":"10.1016/j.imr.2024.101097","url":null,"abstract":"<div><h3>Background</h3><div>Little is known about the effect of electroacupuncture (EA) on cerebral blood flow. We investigated this question in patients undergoing laparoscopic cholecystectomy, hypothesizing that EA would increase cerebral blood flow during surgery.</div></div><div><h3>Methods</h3><div>Eighty-two patients undergoing laparoscopic cholecystectomy were randomly divided into receiving electroacupuncture and intravenous anesthesia (EA+IA) and receving intravenous anesthesia alone (IA). The patients in EA+IA were treated with EA at Baihui (GV 20), Shuigou (GV 26), unilateral Neiguan (PC 6) and unilateral Zusanli (ST 36) points 20 min before anesthesia until the end of the operation. The patients in IA received intravenous anesthesia alone. The internal carotid artery blood flow (Q), mean arterial pressure (MAP), end-tidal carbon dioxide pressure (P_ETCO₂) and heart rate (HR) were recorded respectively before anesthesia induction (T₁), 2 min after anesthesia induction (T₂), 1 min after pneumoperitoneum (T₃), 1 min after head-up tilt (T₄) and after anesthesia resuscitation (T₅).</div></div><div><h3>Results</h3><div>The internal carotid artery blood flow was significantly higher in EA+IA (mean [SD], T₃, 294.0 [89.6] ml min^-1; T₄, 303.8 [90.6] ml min^-1) than in IA (mean [SD], T₃, 246.4 [80.9] ml min^-1; T4, 253.5 [78.4] ml min^-1) at T₃ and T₄ (<em>P</em> &lt; 0.05). There was no difference in blood flow between the two groups at T₂ and T₅. As compared with baseline (T₁), the internal carotid artery blood flow decreased at T₂-T₄ in two groups (<em>P</em> &lt; 0.05). There were no differences in MAP, P_ETCO₂, and HR between the two groups.</div></div><div><h3>Conclusion</h3><div>Electroacupuncture intervention could reduce the decline of internal carotid artery blood flow in patients undergoing laparoscopic cholecystectomy.</div></div><div><h3>Trial registration</h3><div>ChiCTR: 2,100,041,761.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101097"},"PeriodicalIF":2.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of and factors associated with trauma surgeons' referral and patients' willingness to acupuncture treatment after traumatic rib fractures: A single-center cross-sectional study","authors":"Min Ha Kim ,&nbsp;Hyun Min Cho ,&nbsp;Seon Hee Kim ,&nbsp;Youngwoong Kim ,&nbsp;Yu Kyung Shin ,&nbsp;Kun Hyung Kim","doi":"10.1016/j.imr.2024.101096","DOIUrl":"10.1016/j.imr.2024.101096","url":null,"abstract":"<div><h3>Background</h3><div>Pain after traumatic rib fractures (TRF) detrimentally affects the injured. Multidisciplinary pain management is crucial for patient care. There is little empirical evidence on acupuncture as a multidisciplinary treatment for patients with TRF. This study aimed to illustrate the characteristics of the patients referred for or received acupuncture and explore the associated factors.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of Korean Trauma Data Bank and electronic medical records of patients aged 19 or older with TRF from August 2016 to October 2021 in the regional trauma center of Pusan National University Hospital. The sociodemographic and clinical characteristics of patients referred for acupuncture by trauma surgeons and those who received acupuncture were analysed descriptively. In multivariable logistic regression analyses, associations between covariates and either surgeon referrals for or patient willingness to receive acupuncture were quantitatively estimated.</div></div><div><h3>Results</h3><div>Among 2,937 injured patients, trauma surgeons referred 178 (6.1 %) to acupuncture. Among the referred patients, 111 (72.1 %) underwent acupuncture. Patients with polytrauma (aOR 0.46; 0.30 to 0.68) were less likely to be referred to acupuncture, whereas female patients (aOR 3.92, 1.31 to 11.77) were most likely to receive acupuncture.</div></div><div><h3>Conclusions</h3><div>A small proportion of patients with TRF were referred for acupuncture, but the referred patients were more likely to receive acupuncture. Polytrauma may be an important criterion for referral to acupuncture services from the perspective of trauma surgeons, while the willingness to receive acupuncture may be associated with gender-related factors. Further studies are warranted to investigate the role of acupuncture in the postinjury care of patients with TRF.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101096"},"PeriodicalIF":2.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions of traditional Chinese medicine in treating polycystic ovary syndrome: a group consensus","authors":"Tianyi Zhou ,&nbsp;Fangfang Wang ,&nbsp;Xinfen Xu ,&nbsp;Yuhang Zhu ,&nbsp;Rong Zhang ,&nbsp;Hye Won Lee ,&nbsp;Xiao-Yang Mio Hu ,&nbsp;Fan Qu ,&nbsp;Minchen Dai ,&nbsp;Yijing He ,&nbsp;Xinyue Li ,&nbsp;Zhichun Jin ,&nbsp;Yan Yin ,&nbsp;Ziming Huang ,&nbsp;Kaiqing Lin ,&nbsp;Bianba Zhuoma ,&nbsp;Xiaoyong Chen ,&nbsp;Mali Chen ,&nbsp;Longlong Fan ,&nbsp;Lanzhong Guo ,&nbsp;Dan Pan","doi":"10.1016/j.imr.2024.101093","DOIUrl":"10.1016/j.imr.2024.101093","url":null,"abstract":"<div><h3>Background</h3><div>To make a group consensus about non-pharmacological interventions of traditional Chinese medicine in treating polycystic ovary syndrome based on the previous guidelines, literature, and expert viewpoints.</div></div><div><h3>Methods</h3><div>Organized by Chinese Integrative Medicine &amp; Traditional Chinese Medicine Academy, Chinese Maternal and Child Health Association, China, 29 experts from 18 Chinese provinces and 2 international experts, who specialize in gynecology, obstetrics, pediatrics, endocrinology, cardiovascular, psychology, reproductive genetics, nursing, acupuncture and tuina, traditional Chinese medicine, integrative medicine, and other disciplines, discussed and revised the recommendations one by one through in-person or online communication. Each recommendation was approved by ≥90% of the experts before it could be established. The main outcome measure is an optimal clinical regimen for addressing the requirements of women with PCOS and improving their quality of life.</div></div><div><h3>Result(s)</h3><div>The writing panel drafted the initial report, following a consensus process via adequate communication, which was then reviewed and revised by the consensus panel. This consensus provides 12 non-pharmacological interventions (including acupuncture, thumbtack needle, thread-embedding therapy, TEAS, AA, acupoint hot compress, cupping, acupressure, moxibustion, five elements music, aromatherapy, traditional Chinese exercises) for 8 phenotypes of PCOS, resulting in 34 items of clinical practice recommendations.</div></div><div><h3>Conclusion(s)</h3><div>The consensus provides 12 non-pharmacological interventions of traditional Chinese medicine for 8 phenotypes of PCOS, resulting in 34 items of clinical practice recommendations, which may be improved by more high-quality multicenter clinical trials.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101093"},"PeriodicalIF":2.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in the emergency department (ACUITY): Results from a BraveNet multi-center feasibility randomized controlled trial","authors":"Jeffery A. Dusek ,&nbsp;Gene A. Kallenberg ,&nbsp;Alan B. Storrow ,&nbsp;Robert M. Hughes ,&nbsp;Christopher J. Coyne ,&nbsp;David R. Vago ,&nbsp;Arya Nielsen ,&nbsp;Alison Karasz ,&nbsp;Ryung S. Kim ,&nbsp;Jessica Surdam ,&nbsp;Tracy Segall ,&nbsp;Kiran A. Faryar ,&nbsp;Natalie L. Dyer ,&nbsp;Bruce A. Barton ,&nbsp;M. Diane McKee","doi":"10.1016/j.imr.2024.101095","DOIUrl":"10.1016/j.imr.2024.101095","url":null,"abstract":"<div><h3>Background</h3><div>Pain plays a significant role in emergency department (ED) visits, however safe and effective nonpharmacologic options are needed. Prior studies of acupuncture in the ED reported pain reduction with minimal side effects, but most were small and single site.</div></div><div><h3>Methods</h3><div>We conducted ACUITY, a prospectively designed multi-center feasibility RCT. Our goal was to recruit 165 adults with acute non-emergent pain ≥4 on a 0–10-point scale at three EDs affiliated with BraveNet Practice Based Research Network. At baseline and 45–60 min later (post), participants self-assessed their pain and anxiety using a 0–10 rating scale. The primary feasibility outcome was recruitment of participants, whereas secondary outcomes were retention, and participant/provider acceptability.</div></div><div><h3>Results</h3><div>From May 3, 2021, to September 24, 2022, 632 eligible individuals were approached and 165 enrolled (165/632: 26.1 %), meeting our recruitment goal. Notably, 42.4 % of enrollees were Black/African American, 42.4 % were White/Caucasian, and 13.9 % were Hispanic/Latino. Participants were randomized to Acupuncture (<em>n</em> = 83) or Usual care (<em>n</em> = 82), of which 151 (91.5 %) and 128 (77.6 %) provided pain and anxiety scores at post-treatment and 1-week respectively. Acupuncture was rated acceptable to participants and providers. Mean pain ratings (pre-to-post) were 7.4 (2.2) to 4.8 (2.8) for acupuncture and 7.1 (2.3) to 6.4 (2.5) for usual care. Mean anxiety ratings (pre-to-post) were 4.5 (3.4) to 2.5 (2.6) for acupuncture and 4.1 (3.4) to 3.5 (3.2) for usual care.</div></div><div><h3>Conclusion</h3><div>Successful completion of ACUITY indicates we have the expertise and preliminary data to conduct a future definitive, multi-center RCT.</div></div><div><h3>Trial registration: Clinical trials.gov</h3><div>NCT04880733.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101095"},"PeriodicalIF":2.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical cannabis: From research breakthroughs to shifting public perceptions and ensuring safe use","authors":"Muhammad Kamal Hossain ,&nbsp;Han Jung Chae","doi":"10.1016/j.imr.2024.101094","DOIUrl":"10.1016/j.imr.2024.101094","url":null,"abstract":"<div><div>The landscape of medical cannabis has evolved dramatically over the past few decades. Once stigmatized and illegal in most parts of the world, cannabis is now recognized for its potential therapeutic benefits, supported by an expanding body of scientific research. However, the transition from prohibition to medical recognition is shaped by complex interactions among scientific advancements, public perception and regulatory frameworks for its legalization. This review examines the recent breakthroughs in medical cannabis research, explores the shifting public perceptions and the stigma associated with its use and discusses strategies for enhancing the safety of medical cannabis. We also synthesize the connections between scientific research, public perception and safety considerations in the uses of medical cannabis, providing a comprehensive understanding of how these elements influence each other and shape the future of medical cannabis use for patient adherence.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"13 4","pages":"Article 101094"},"PeriodicalIF":2.8,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}