Integrative Medicine Research最新文献

{"title":"Safety of herbal medicine in the postpartum period: A hospital-based single-arm, prospective observational study (SAFEHERE-PC)","authors":"Anna Kim ,&nbsp;Young Eun Kim ,&nbsp;Sumin Seo ,&nbsp;Sungha Kim ,&nbsp;Eunbyul Cho ,&nbsp;Yujeong Kang ,&nbsp;Eunhee Lee ,&nbsp;Mi Ju Son","doi":"10.1016/j.imr.2025.101280","DOIUrl":"10.1016/j.imr.2025.101280","url":null,"abstract":"<div><h3>Background</h3><div>Herbal medicines (HMs) are commonly used during the postpartum period in South Korea; however, comprehensive data regarding their safety remain limited. This study aimed to evaluate the safety of HM use among postpartum women through the “SAFEty of HErbal medicine REgistry in Postpartum Care center” (SAFEHERE-PC) study.</div></div><div><h3>Methods</h3><div>A single-arm, prospective observational study was conducted from March to December 2024, enrolling 186 women within six weeks postpartum who were admitted to the postpartum care center of a Korean Medicine hospital. The study monitored adverse events (AEs) during HM use, collecting demographic information, medical history, herbal prescription details, and AE data. Reported AEs were analyzed using the WHO-UMC causality assessment and the Naranjo algorithm.</div></div><div><h3>Results</h3><div>Of the 186 participants, 4 (2.2 %) experienced AEs following HM administration, all of which were gastrointestinal symptoms (diarrhea, loose stools). Three of the five events were managed with a short course of the herbal formula, and two cases resolved spontaneously without requiring medical intervention. Based on severity and clinical course, the events were classified as mild to moderate. Causality assessment using the WHO-UMC system classified four cases as \"possible\" and one as \"certain\", while the Naranjo scale indicated three cases as \"possible\" and two as \"probable\" in their association with HM use.</div></div><div><h3>Conclusion</h3><div>A low incidence of mild gastrointestinal AEs (2.2 % of patients; 0.6 % of prescriptions) was observed, with no serious AEs reported. These findings provide descriptive safety data specific to the formulations and clinical practices used at this hospital-based postpartum care center.</div></div><div><h3>Trial registration</h3><div>Korean National Clinical Trial Registry Clinical Research Information Service: KCT0009060.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101280"},"PeriodicalIF":3.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of herbal medicine decoction for facial palsy: Coarsened exact matching analysis of the national health insurance database","authors":"Yongjoo Kim ,&nbsp;Nan-He Yoon ,&nbsp;Soobin Jang ,&nbsp;Kyeore Bae ,&nbsp;Wonkyung Moon ,&nbsp;Minjung Park ,&nbsp;Sujin Kim","doi":"10.1016/j.imr.2025.101279","DOIUrl":"10.1016/j.imr.2025.101279","url":null,"abstract":"<div><h3>Background</h3><div>Herbal medicine decoctions (HMD) are potential treatments for Bell’s palsy (BP), but real-world evidence regarding the safety is limited. This study investigated whether HMD use for BP was associated with risk of adverse events using a nationwide claims-based database in South Korea.</div></div><div><h3>Methods</h3><div>This retrospective cohort study used data from the Korean Health Insurance Review and Assessment database. We applied coarsened exact matching, through which 1627 BP patients who received at least one HMD prescription between November 2020 and February 2022 were matched with 1627 BP patients who did not use HMD. Difference-in-differences logistic regression modeling compared the incidences of safety outcomes between HMD users and non-users.</div></div><div><h3>Results</h3><div>No significant differences were observed in the risk of hepatotoxicity, renal failure, allergic events, hospitalization, and emergency department visits between HMD users and non-users with BP, assessed at 3, 6, 9 and 11 months after HMD prescription. All effect estimates and corresponding 95 % confidence intervals included the null value.</div></div><div><h3>Conclusions</h3><div>There was no significant difference in the risk of safety outcomes between HMD users and non-users with BP. Further research is warranted to understand the safety of specific herbal formulas or individual herbs using broader safety measures.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101279"},"PeriodicalIF":3.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture electroceuticals: The convergence of traditional acupuncture theory and modern bioelectronic medicine","authors":"Sanghun Lee ,&nbsp;Sunmi Choi","doi":"10.1016/j.imr.2025.101267","DOIUrl":"10.1016/j.imr.2025.101267","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101267"},"PeriodicalIF":3.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring traditional Chinese medicine tongue diagnosis in potential cancer identification: A scoping review","authors":"Maria Benxia Wu ,&nbsp;Yong-Kang Wu ,&nbsp;Meng-Hua Chen ,&nbsp;Benjamin Kimble ,&nbsp;Brian May ,&nbsp;Vincent Chan ,&nbsp;Stella Stylianou ,&nbsp;Bin Xu ,&nbsp;Daniel Man-yuen Sze ,&nbsp;Zhen Zheng","doi":"10.1016/j.imr.2025.101265","DOIUrl":"10.1016/j.imr.2025.101265","url":null,"abstract":"<div><h3>Background</h3><div>Traditional Chinese medicine (TCM) tongue diagnosis entails the systematic evaluation of morphological characteristics (tongue features) on both dorsal and ventral tongue surfaces. Recent advancements in research have highlighted the potential diagnostic relevance of specific tongue features for cancer detection and monitoring through various inspection methodologies. This scoping review aims to provide a comprehensive overview of tongue features investigated in relation to cancer detection.</div></div><div><h3>Methods</h3><div>A literature search for clinical studies (excluding case reports) that examined the application of tongue inspection for detecting cancer, recurrence, or metastasis was conducted. Extracted data included study characteristics, patient populations, inspection techniques, and diagnostic outcomes.</div></div><div><h3>Results</h3><div>Twenty-four studies consisting of 14 case-control studies, 4 cross sectional studies, 5 observational study, and 1 prospective multicentred cohort were identified, involving a total of 5458 cancer patients and 7880 control participants. Documented tongue features included lingual flange protrusion, sublingual nodules, engorged sublingual veins, purple-bluish tongue, and variations in tongue coating thickness, etc. that were associated with different cancer types and metastasis. Using QUADAS-2, the overall quality was low with potentially high risk of bias in some key domains, especially participant selection and index test.</div></div><div><h3>Conclusion</h3><div>The findings from this review provide a foundation for future research questions aimed at high-level observational studies. Tongue inspection holds promise as a cost-effective, time-efficient, and non-invasive method for detecting cancers and metastasis. Based on quality assessment, the study highlights future needs such as more prospective, blinded interpretation, pre-specified thresholds, and transparent reporting to improve both methodological rigor and external validity.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101265"},"PeriodicalIF":3.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145972673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of medicinal and edible herbs from seed sources for human consumption: A systematic review","authors":"Lixia Yuan ,&nbsp;Bofei Shu ,&nbsp;Jieyi Zhou ,&nbsp;Wenxi Li ,&nbsp;Hui Wang ,&nbsp;Xu Zhou","doi":"10.1016/j.imr.2025.101263","DOIUrl":"10.1016/j.imr.2025.101263","url":null,"abstract":"<div><h3>Background</h3><div>Plant seeds constitute an important category of medicinal and edible herbs. However, assessments regarding their safety for human consumption remain insufficient. This systematic review comprehensively evaluates human safety for 21 medicinal and edible seeds.</div></div><div><h3>Methods</h3><div>Two independent reviewers screened the titles, abstracts, and fulltexts of the retrieved literature against the inclusion and exclusion criteria to identify eligible AE reports in both English (PubMed, Embase, CENTRAL) and Chinese (CNKI, Wanfang, VIP, SinoMed) databases. Search strategies were constructed using the scientific names, common names, and frequent aliases of the medicinal and edible seeds combined with safety evaluation keywords such as \"adverse reaction,\" \"toxicity,\" and \"side effect.\" Any studies describing adverse event (AE) after human intake of specific seeds were included. AE characteristics were summarized. Causality between seed consumption and AEs was assessed.</div></div><div><h3>Results</h3><div>We identified 703 AEs involving eight medicinal and edible seeds. Ginkgo semen and Armeniacae semen amarum caused the most AEs, followed by Persicae semen, Myristicae semen, Sterculiae lychnophorae semen, Canavaliae semen, Cassiae semen, and Ziziphi spinosae semen. Among the AEs, 70.8% occurred in children, and 68.9% were associated with excessive intake. Most AEs manifested as gastrointestinal and/or neurological symptoms. Ninety-six were classified as serious; these were caused by Ginkgo semen (29 cases), Armeniacae semen amarum (60 cases), Persicae semen (4 cases), Canavaliae semen (2 cases), and Myristicae semen (1 case). These SAEs resulted in 15 fatalities and 3 cases of permanent functional impairment. Causality with seed consumption was determined to be \"certain\" for 239 AEs, \"probable\" for 449, and \"possible\" for 15. No AE reports were found for thirteen seeds.</div></div><div><h3>Conclusion</h3><div>Consuming specific medicinal and edible seeds, particularly Ginkgo semen, Armeniacae semen amarum, Persicae semen, Myristicae semen, and Canavaliae semen, poses potential risks, including fatal cases. Excessive dosages, consumption by children, and inappropriate processing were primary causes. Therefore, strengthening safety management for these is warranted.</div></div><div><h3>Protocol registration</h3><div>PROSPERO (No. CRD42023426497).</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101263"},"PeriodicalIF":3.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of pomegranate hot-water extract via inhibition of apoptosis and oxidative stress in a DHEA-induced mouse model of PCOS","authors":"Sohee Moon ,&nbsp;Yena Oh ,&nbsp;Hajin Noh ,&nbsp;Soo Dong Kim ,&nbsp;Jae Youl Cho","doi":"10.1016/j.imr.2025.101264","DOIUrl":"10.1016/j.imr.2025.101264","url":null,"abstract":"<div><h3>Background</h3><div>Polycystic ovarian syndrome (PCOS), which affects approximately 10 % of women of reproductive age worldwide, is closely associated with metabolic disturbances such as obesity and insulin resistance. Despite its high prevalence, the pathophysiology of PCOS is still not fully understood, underscoring the need for appropriate animal models and effective therapeutic strategies.</div></div><div><h3>Methods</h3><div>In this study, we established a PCOS mouse model through subcutaneous administration of dehydroepiandrosterone (DHEA) and investigated the therapeutic potential of a pomegranate (<em>Punica granatum</em> L.) hot water extract (Pg-hWE) (also called ESTROBAL®), administered orally.</div></div><div><h3>Results</h3><div>Histological analysis of ovarian tissue sections of mice showed that Pg-hWE improved ovulation function and suppressed cell death of follicles by promoting maintenance and regeneration of corpus luteum and reducing the number of atretic follicles. Furthermore, Pg-hWE showed inhibitory effects on gene and protein levels of apoptosis factors such as BAX, cleaved caspase-3, and cleaved caspase-9 in ovarian and uterine tissues. In addition, in ovarian tissues, it promoted apoptosis such as BAX and inhibited the expression of inflammation-related genes such as IL-6, TNF-α, and IFN-γ, while increasing the expression of Bcl-2, an anti-apoptosis factor. Plus, Pg-hWE demonstrated the ability to modulate hormonal balance by regulating the expression of CYP11A1 and CYP17A1, key genes encoding enzymes involved in androgen biosynthesis. Supporting these findings, studies using CHO-K1 cells confirmed that Pg-hWE exerts both anti-apoptotic and antioxidant effects, thereby linking its roles in mitigating PCOS, suppressing cell death, and controlling oxidative stress.</div></div><div><h3>Conclusion</h3><div>Collectively, these results indicate that Pg-hWE ameliorates PCOS-related pathology by reducing oxidative stress, suppressing apoptosis, and supporting hormonal balance, highlighting its promise as a natural therapeutic candidate.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101264"},"PeriodicalIF":3.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practitioner Experiences of Integrative health CarE [PEICE]: A qualitative descriptive study","authors":"Matthew J. Leach ,&nbsp;Yasamin Veziari ,&nbsp;Simon DuBois ,&nbsp;Reine DuBois","doi":"10.1016/j.imr.2025.101261","DOIUrl":"10.1016/j.imr.2025.101261","url":null,"abstract":"<div><h3>Background</h3><div>Evidence suggests that some models of care may have a positive impact on health worker wellbeing and retention. This study set out to understand health practitioners’ experiences of working within an integrative health care (IHC) setting in Australia, and the impact of such on practitioners’ clinical behaviour and well-being.</div></div><div><h3>Methods</h3><div>The study employed a qualitative descriptive design and purposive sampling. Health care practitioners of any discipline working in an IHC setting in Australia in a clinical capacity were invited to participate in an online, semi-structured interview. Interview audio-recordings were transcribed verbatim and analysed using deductive thematic analysis.</div></div><div><h3>Results</h3><div>Twenty-four health practitioners from twelve distinct professions partook in an interview. Four themes emerged from the data, including (i) Transition to practice (e.g. Changed approach to patient care), (ii) Professional interactions (e.g. changing perceptions of, and relationships with other healthcare providers), (iii) Job satisfaction (e.g. rewards and frustrations of working in an IHC setting), and (iv) Impacts on health and wellbeing (e.g. positive and negative health impacts).</div></div><div><h3>Conclusion</h3><div>The study uncovered new insights into health practitioners’ experiences of working within an IHC setting; including impacts on clinical knowledge, skills, behaviours and relationships, as well as practitioner health, wellbeing and job satisfaction. Given the potential implications of these findings on health workforce supply, quality of care and patient satisfaction, there is a need to build upon this work to determine whether the implementation of IHC models of care in different settings yields meaningful and sustainable clinical, social and economic benefit.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101261"},"PeriodicalIF":3.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in integrative medicine: Transforming education for a digital future","authors":"Darshan H. Mehta ,&nbsp;Melinda Ring","doi":"10.1016/j.imr.2025.101259","DOIUrl":"10.1016/j.imr.2025.101259","url":null,"abstract":"","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"14 4","pages":"Article 101259"},"PeriodicalIF":3.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective registration of guidelines and consensus statements of traditional and integrative medicine: Current status and experience from the PREPARE platform","authors":"Xuan Yu ,&nbsp;Jie Zhang ,&nbsp;Janne Estill ,&nbsp;Zhaoxiang Bian ,&nbsp;Yaolong Chen","doi":"10.1016/j.imr.2025.101260","DOIUrl":"10.1016/j.imr.2025.101260","url":null,"abstract":"<div><h3>Background</h3><div>Prospective registration of guidelines enhances transparency and reduces research waste. With the growing number of Traditional and Integrative Medicine (TIM) guidelines, the purpose of this study was to analyze the registrations of TIM guidelines and consensus statements on the Practice guideline REgistration for transPAREncy (PREPARE) platform.</div></div><div><h3>Methods</h3><div>All TIM guidelines and consensus statements registered on PREPARE by December 31, 2024, were included. Data on registration year, type, category, country, evidence grading, funding, use of systematic reviews, and protocols were extracted and summarized as frequencies and percentages.</div></div><div><h3>Results</h3><div>As of December 31, 2024, a total of 3434 projects had been registered on PREPARE, of which 587 (17.1%) pertained to traditional and integrative medicine. Among these, 380 (64.7%) were traditional medicine guidelines and consensus statements, and 207 (35.3%) involved integrative medicine. Of the TIM-related guidelines and consensus statements, 401 were standard guidelines and 150 were consensus statements; most (551/587, 93.9%) were registrations for original versions. Nearly half (268/587, 45.7%) addressed both diagnostic and treatment procedures. The majority of registrations (511/587, 87.1%) reported that systematic reviews would inform guidelines and consensus statements. Furthermore, 501 (85.3%) guidelines and consensus statements stated they would grade the strength of evidence and recommendations, with the grading methods specified. Approximately 80% (466/587) explicitly reported their sources of funding, amounting to 632 individual funding sources.</div></div><div><h3>Conclusion</h3><div>Despite increased use of public platforms for registration, further efforts are needed to improve awareness and practice. The PREPARE working group will collaborate with TIM guideline developers to implement initiatives that advance the rigor, transparency, and usability of TIM guidelines and consensus statements.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101260"},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145690704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive value evaluation index system for provincial medical insurance access to traditional Chinese medicine preparations in medical institutions","authors":"Xinyan Jin ,&nbsp;Changgeng Su ,&nbsp;Jiale Zhang ,&nbsp;Yujuan Liu ,&nbsp;Xiaoying Chen ,&nbsp;Rui Zhao","doi":"10.1016/j.imr.2025.101258","DOIUrl":"10.1016/j.imr.2025.101258","url":null,"abstract":"<div><h3>Background</h3><div>This study established a comprehensive value evaluation index system for provincial medical insurance access to traditional Chinese medicine (TCM) preparations in medical institutions from the insurance viewpoint. The system aims to provide a reference for insurance access applications and decision-making.</div></div><div><h3>Methods</h3><div>The index system was first established through systematic evaluation and expert consultation. The Delphi method and analytic hierarchy process were employed to reveal the index system and calculate each indicator’s weight. The indicator selection thresholds were based on the importance score thresholds and the coefficient of variation thresholds. Indicators with importance scores higher than the threshold and coefficient of variation less than the threshold were included in the index system.</div></div><div><h3>Results</h3><div>The researchers retrieved 6201 articles in total, 68 of which were retained following a review of the titles and full text. The initially established index system had six dimensions (i.e., basic information and TCM theory of the preparation, safety, effectiveness, economy, innovation, and fairness), 25 primary indicators, and 55 secondary indicators. Two expert consultation rounds were employed to collect the opinions of 13 and 11 experts. The final index system considered the index system’s aforementioned six dimensions, including safety (30.44 %), effectiveness (43.18 %), economy (14.72 %), innovation (6.48 %), and fairness (5.17 %), along with 22 primary indicators, and 26 secondary indicators. Moreover, the top three weight indicators were the prescription source (secondary indicator), effectiveness evaluation based on real-world evidence (primary indicator), and direct costs (secondary indicator).</div></div><div><h3>Conclusion</h3><div>The proposed index system elucidates the scope of evidence and basic research design for TCM preparations from the insurance viewpoint. It also integrates cost evaluation and value evaluation indicators and improves the definition of reference drugs, thus providing a reference for achieving rational clinical drug usage and a pricing policy for TCM preparations.</div></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":"15 2","pages":"Article 101258"},"PeriodicalIF":3.0,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}