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The Clinico-Hematological assessment and feto-maternal outcome of pancytopenia during pregnancy 妊娠期间全血细胞减少症的临床血液学评估和胎母结局
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1668004351
Shobhana Singh, R. Fuke, Kirti Rachwani
Introduction: Pancytopenia is defined as decrease in all three cellular elements of peripheral blood leading to anemia, leucopenia and thrombocytopenia1.Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dyspnea, and bleeding, bruising and increased tendency to infections2. The most common causes leading to pancytopenia on bone marrow examination are hypoplastic/aplastic bone marrow (29.05%), megaloblastic anemia (23.64%), hematological malignancies i.e. acute myeloid leukemia (21.62%), and erythroid hyperplasia (19.6%).3 The commonest clinical manifestations of pancytopenia are usually fever (86.7%), fatigue (76%), dizziness (64%), weight loss (45.3%), anorexia (37.3%), night sweats (28%), pallor (100%), bleeding (38.7%), and spleenomegaly (48%). A pregnancy complicated by severe AA is a great challenge for obstetricians.4,5 Objective: To assess the clinico-hematological parameters and & fetal outcomes among pregnant mothers with pancytopenia. Methods: Pregnant mothers with pancytopenia visiting ANC OPD or admitted patients were enrolled into the study with sample size of 96. Written informed consent was taken and study design explained to them, and the investigations were done and data was collected. Results and discussion: subjects presented with symptoms of pancytopenia like pallor, bleeding diathesis, fatigue and fever, glossitis cheilosis. Platelet count of 30 % of subjects were in the range of 71000 to 90000. 32.3 % mothers had megaloblastic anaemia, Aplastic anaemia was present in 18.7 % and pregnancy induced hypertension in 14.7 % subjects, and eclampsia in 5.2 % subjects. Conclusion: Association of pancytopenia with pregnancy is a rare entity yet it has increased risk of adverse maternal and foetal outcome. Early diagnosis and intervention bring favourable maternal and foetal outcome. This study identified the risk factors of mortality and morbidity in pregnant women with severe aplastic anaemia as well as the obstetrical complications associated with neonatal outcome. Key words: AA-Aplastic anaemia
全血细胞减少症定义为外周血中所有三种细胞成分的减少,导致贫血、白细胞减少和血小板减少。全血细胞减少症通常表现为骨髓衰竭的症状,如脸色苍白、呼吸困难、出血、瘀伤和感染倾向增加2。骨髓检查中导致全血细胞减少的最常见原因是骨髓发育不良/再生障碍性贫血(29.05%)、巨幼细胞性贫血(23.64%)、血液恶性肿瘤如急性髓性白血病(21.62%)和红细胞增生(19.6%)全血细胞减少症最常见的临床表现为发热(86.7%)、疲劳(76%)、头晕(64%)、体重减轻(45.3%)、厌食(37.3%)、盗汗(28%)、面色苍白(100%)、出血(38.7%)、脾肿大(48%)。妊娠合并严重的酒精中毒对产科医生来说是一个巨大的挑战。[4,5]目的:探讨全血细胞减少孕妇的临床血液学指标及胎儿结局。方法:采用全血细胞减少孕妇来非国大门诊就诊或住院患者为研究对象,样本量为96例。获得书面知情同意,向他们解释研究设计,完成调查并收集数据。结果和讨论:受试者出现全血细胞减少的症状,如苍白、出血、疲劳和发热、舌炎和舌裂。30%的受试者血小板计数在71000 ~ 90000之间。32.3%的母亲患有巨幼细胞性贫血,18.7%的母亲患有再生障碍性贫血,14.7%的母亲患有妊娠高血压,5.2%的母亲患有子痫。结论:全血细胞减少症与妊娠的关联是一个罕见的实体,但它增加了孕产妇和胎儿不良结局的风险。早期诊断和干预可带来良好的母婴结局。本研究确定了严重再生障碍性贫血孕妇死亡率和发病率的危险因素,以及与新生儿结局相关的产科并发症。关键词:再生障碍性贫血
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引用次数: 0
Perceptive social support among parents of children with autism spectrum disorder 自闭症谱系障碍儿童父母的感知社会支持
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1669800300
A. Curval, Ana Igreja, V. Viana, M. Guardiano
Introduction Social support, especially as provided by close family and friends, has been consistently identified as one of the most powerful predictors of psychological adjustment among parents raising children with ASD. Material and methods A cross-sectional study including 51 parents of children with ASD was carried out in our pediatric development department. The objective of the study was to verify the degree of satisfaction of the participants regarding their family, friends, intimacy, and social activities. Results There was a negative correlation between the children’s age and the degree of parental satisfaction. There was a statistically significant association between the parents' educational level and the degree of satisfaction reported by them in all domains, except for the family domain. Conclusion Based on study findings regarding the importance of help from parents’ informal social network, special attention in this regard should be focused on developing services that assist parents in making more effective use of existing sources of support from family members, friends, and other parents of children with ASD.
社会支持,尤其是亲密的家人和朋友提供的支持,一直被认为是养育自闭症儿童的父母心理适应的最有力的预测因素之一。材料与方法对我院儿科发育科51名ASD患儿家长进行横断面研究。这项研究的目的是验证参与者对他们的家庭、朋友、亲密关系和社会活动的满意度。结果儿童年龄与父母满意度呈负相关。除家庭领域外,家长受教育程度与家庭满意度在各领域均呈显著相关。结论基于父母非正式社会网络帮助的重要性的研究发现,在这方面应该特别关注开发服务,帮助父母更有效地利用来自家庭成员、朋友和其他自闭症儿童父母的现有支持来源。
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引用次数: 0
Immune Thrombocytopenic Purpura presenting as paraneoplastic syndrome in a Dedifferentiated Liposarcoma: A case report 免疫性血小板减少性紫癜在去分化脂肪肉瘤中表现为副肿瘤综合征:1例报告
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1672101017
J. es, M. Coelho, A. Nunes, Inês Antunes, A. Costa
Introduction: Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by isolated low platelet counts, that occurs because of increased platelet destruction by the production of autoantibodies against platelet antigens. ITP secondary to solid neoplasia is rare. The treatment consists of pharmacological treatment to improve thrombocytopenia and the treatment of the underlying malignancy. Case Report: A 72-year-old woman was admitted in the emergency department with petechial lesions and spontaneous ecchymosis with about three weeks of evolution. Analytically confirmed severe thrombocytopenia, without anemia and normal leukogram, and positive direct antigliadin test, admitting thrombocytopenic purpura. In the subsequent etiological study, a nodular formation was identified in the right para renal area, later biopsied confirming the diagnosis of dedifferentiated retroperitoneal liposarcoma. Despite an initial favorable response to corticosteroid therapy, there was persistence of low platelet count despite first-line therapy (corticosteroids and immunoglobulin), with the need to associate second-line drugs (rituximab and Eltrombopag). There was remission of ITP after complete tumor excision. Conclusion: The association of immune thrombocytopenia with dedifferentiated liposarcoma is very rare, with only one previous case described in the medical literature. The treatment of an underlying malignancy may lead to resolution of thrombocytopenia, which is why, although the association of ITP with solid tumors is very uncommon, it is important to screen for solid tumor in the etiological study of ITP. KEYWORDS Immune thrombocytopenia, dedifferentiated retroperitoneal liposarcoma, paraneoplastic syndrome.
免疫性血小板减少症(ITP)是一种自身免疫性出血性疾病,其特征是孤立性血小板计数低,这是由于血小板抗原自身抗体的产生导致血小板破坏增加而发生的。继发于实体瘤变的ITP是罕见的。治疗包括药物治疗以改善血小板减少症和治疗潜在的恶性肿瘤。病例报告:一名72岁妇女因点状病变和自发性瘀斑而入院急诊科,病程发展约三周。分析证实严重血小板减少症,无贫血,白细胞图正常,直接抗麦胶蛋白试验阳性,承认血小板减少性紫癜。在随后的病因学研究中,在右侧肾旁区发现了结节状形成,后来活检证实了去分化腹膜后脂肪肉瘤的诊断。尽管最初对皮质类固醇治疗有良好的反应,但尽管一线治疗(皮质类固醇和免疫球蛋白),血小板计数仍持续较低,需要联合二线药物(利妥昔单抗和依曲巴)。肿瘤完全切除后ITP得到缓解。结论:免疫性血小板减少症与去分化脂肪肉瘤的关联是非常罕见的,在医学文献中只报道过一例。治疗潜在的恶性肿瘤可能导致血小板减少症的解决,这就是为什么尽管ITP与实体肿瘤的关联非常罕见,但在ITP的病因学研究中筛查实体肿瘤是很重要的。关键词:免疫性血小板减少症,去分化腹膜后脂肪肉瘤,副肿瘤综合征
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引用次数: 0
Clinico-radiological results of osteosynthesis of unstable fractures of tubular bones of hand using mini fragment plate and screw system. 使用微型碎骨钢板和螺钉系统对手部管状骨不稳定骨折进行骨合成的临床放射学结果。
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1654142315
A. Bhat, T. Motten, Faisal N. Mir, N. Ali, Aabid M. Rather, Mohamad Gilani
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引用次数: 0
Computed Tomography-Chest in COVID-19 Pneumonia and cardiac failure: An Imaging Enigma COVID-19肺炎和心力衰竭的胸部计算机断层扫描:一个成像谜
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1678819573
Dr Majella, Dr Adaikkalam
BACKGROUND- Computed tomography (CT) of the chest is an efficient tool to assess COVID-19 pneumonia. Nevertheless, imaging characteristics that overlap with cardiogenic pulmonary edema are not infrequent. CT chest characteristics pose challenges for which additional transthoracic echocardiography is an additional invaluable simple tool to aid in the diagnosis. In this article, we present the CT chest findings of patients with only covid-19 pneumonia, isolated heart failure, and combined covid-19 pneumonia and heart failure. Methods- This study included 120 patients in a tertiary care hospital in South India with dyspnoea and SP02 ≤ 95% between April 2021 to March 2022 who were subjected to chest CT imaging and transthoracic echocardiography and the results were analyzed. Isolated COVID-19 (n=60), isolated heart failure (n=39), and combined covid-19 pneumonia and heart failure (n-21) were identified depending on the CT chest imaging features. Results- There was no statistical difference in the imaging findings like ground glass opacities, crazy pavementpatternswithCOVID-19pneumonia, HF, and also in combined (covid 19 + cardiac failure )groups. However, in HF patients, diffuse patterns were more common than in COVID-19 pneumonia, which was statistically significant (p=0.001). Notably, CT images in HF patients were more likely to have interlobular septal thickening (ILST)(p=0.001) cardiomegaly (p=0.001), increased artery-to-bronchus ratio (p=0.0001), and bilateral pleural effusion (p=0.0001 ), and pericardial effusion (p=0.0001 ) Conclusion- Chest CT is an indispensable tool in the early diagnosis of COVID-19 pneumonia.CT chest features overlap, and separating COVID-19 pneumonia from heart failure is not always easy. Yet, certain specific CT features may suggest heart failure over covid -19 pneumonia. In HF patients, thickening of the interlobular septa, increased artery-to-bronchus ratio, cardiomegaly, and bilateral pleural effusion, pericardial effusion are more common. Additional transthoracic echo showing dilated left ventricle with reduced ejection fraction is an additional key to aid diagnosis.
背景:胸部计算机断层扫描(CT)是评估COVID-19肺炎的有效工具。然而,与心源性肺水肿重叠的影像学特征并不少见。CT胸部特征提出了挑战,额外的经胸超声心动图是一个额外的宝贵的简单工具,以帮助诊断。在本文中,我们介绍了仅covid-19肺炎、孤立性心力衰竭和合并covid-19肺炎并心力衰竭患者的CT胸部表现。方法:本研究纳入了2021年4月至2022年3月在南印度一家三级医院就诊的120例呼吸困难且SP02≤95%的患者,对其进行胸部CT成像和经胸超声心动图检查,并对结果进行分析。根据CT胸部影像学特征确定孤立性COVID-19 (n=60)、孤立性心力衰竭(n=39)和合并COVID-19肺炎并心力衰竭(n-21)。结果:两组在磨玻璃混浊、疯狂路面模式合并covid -19肺炎、HF以及合并(covid -19 +心力衰竭)组的影像学表现均无统计学差异。然而,在HF患者中,弥漫性模式比COVID-19肺炎更常见,差异有统计学意义(p=0.001)。值得注意的是,HF患者的CT表现更容易出现小叶间隔增厚(ILST)(p=0.001)、心脏增大(p=0.001)、动脉-支气管比值升高(p=0.0001)、双侧胸腔积液(p=0.0001)、心包积液(p=0.0001)。结论-胸部CT是早期诊断COVID-19肺炎不可或缺的工具。CT胸部特征重叠,将COVID-19肺炎与心力衰竭区分开来并不容易。然而,某些特定的CT特征可能提示covid -19肺炎的心力衰竭。在心衰患者中,小叶间隔增厚、动脉与支气管比例增加、心脏肿大、双侧胸腔积液、心包积液更为常见。额外的经胸回声显示左心室扩张和射血分数降低是辅助诊断的另一个关键。
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引用次数: 0
Recurrent Hepatic Encephalopathy Complicated with Hepatic Myelopathy after Secondary Resection with Hepatocellular Carcinoma: A Case Report 肝细胞癌二次切除后复发性肝性脑病并发肝性脊髓病1例
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1684511320
Zhan Ya
Hepatocellular carcinoma (HCC) is celerity increasing throughout the world with a high mortality rate. The progression of HCC in patients is induced mainly by cirrhosis and hepatitis. Surgical treatment has played a crucial role for HCC therapy, especially at the very early/early HCC stage. It is widespread for patients to experience a postoperative complication after surgery, including Hepatic encephalopathy/myelopathy. This case report disclosed in details a patient diagnosed and treated in our hospital suffered from recurrent hepatic encephalopathy along with hepatic myelopathy due to the secondary surgical resection of HCC.
肝细胞癌(HCC)在世界范围内迅速增加,死亡率高。HCC患者的进展主要是由肝硬化和肝炎引起的。手术治疗在HCC治疗中起着至关重要的作用,特别是在HCC的早期阶段。患者在手术后出现术后并发症是很普遍的,包括肝性脑病/脊髓病。本病例报告详细披露了一位在我院诊治的患者,因肝癌二期手术切除,复发性肝性脑病合并肝性脊髓病。
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引用次数: 0
Assessment of expressed emotions in caregiver of dementia patients: Its sociodemographic and clinical correlates 痴呆症患者护理人员的情绪表达评估:其社会人口学和临床相关性
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1682483223
P. Rastogi, V. Niranjan, R. Mathur, Prashant Maravi, Vijay Raghuwanshi
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引用次数: 0
Incidental Breast Cancer after Reduction Mammoplasty, a Case Report. 缩小乳房成形术后偶发乳癌1例报告。
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1672425445
Alexandra J. Ferreira, P. Ferreira, Rodrigo Rosenfeld, Arymar Junior, L. Branco, M. Rigueira, L. Cortez
Reduction mammoplasty is one of the most common plastic surgeries performed around the world. Incidental breast cancer found in the reduction specimen is rare and its management is challenging. Preoperative assessment is crucial in identifying risk factors that increase the likelihood of breast cancer and that require further investigation. Mammography remains the most practical and cost-effective method for preoperative breast cancer screening but some tumors are occult. Marking the orientation of the reduction mammoplasty specimen is extremely important to allow the evaluation and guarantee adequate margins. Sentinel node biopsy is possible after reduction mammoplasty. This case report is about a 49-year-old woman with no risk factors for breast cancer who underwent bilateral reduction mammoplasty for macromastia which revealed an incidental breast tumor. The patient had preoperative mammography and breast ultrasound which did not show any suspicious lesions. She was referred to our Hospital for further evaluation by a multidisciplinary team. After breast MRI without alterations and a negative right axillary sentinel node biopsy, hormone therapy and radiotherapy were started. Incidental breast cancer found in the reduction specimen is rare but its management is challenging therefore surgeons should be aware to this issue. This clinical report intends to alert to this diagnosis and review the literature on this topic.
缩小乳房成形术是世界上最常见的整形手术之一。在复位标本中发现的偶发乳腺癌是罕见的,其管理是具有挑战性的。术前评估对于确定增加乳腺癌可能性的危险因素和需要进一步调查的因素至关重要。乳房x光检查仍然是术前乳腺癌筛查中最实用和最具成本效益的方法,但有些肿瘤是隐匿的。标记缩小乳房成形术标本的方向对于评估和保证足够的边缘是非常重要的。乳房缩小成形术后可以进行前哨淋巴结活检。本病例报告是一名无乳腺癌危险因素的49岁女性,因巨乳症行双侧缩乳成形术后发现偶发乳腺肿瘤。患者术前行乳房x光检查及超声检查未见可疑病变。她被转介到我们医院接受多学科小组的进一步评估。乳房MRI无改变,右腋窝前哨淋巴结活检阴性后,开始激素治疗和放疗。在复位标本中发现偶发乳腺癌是罕见的,但其管理是具有挑战性的,因此外科医生应该意识到这个问题。本临床报告旨在提醒这种诊断,并回顾有关该主题的文献。
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引用次数: 0
Evaluation of neck measurements and their correlation with prediction of difficult laryngoscopic view 颈部测量的评估及其与喉镜观察困难预测的相关性
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1669044162
S. Maddala, A. Gupta, Ira M
INTRODUCTION: Preoperative assessment of various anatomic and clinical features helps in identifying potentially difficult laryngoscopy and intubation in advance allowing the anesthetist to be prepared for such a scenario. Though “ Short Neck” is a commonly used term in airway assessment indicating the possibility of a difficult airway. there is a lack of clarity regrading the cut off value and the association of different neck lengths (Anterior, Posterior and Lateral) to the laryngoscopic view. AIM : Evaluation of anterior, posterior and lateral neck length in neutral and extended positions and correlate each measurement with prediction of difficult laryngoscopic view. MATERIALS AND METHODS : This prospective observational study was conducted on 150 patients belonging to American Society of Anesthesiologists (ASA) grade 1/11 , aged 18-65 years with body mass index (BMI) 18 to 35 kg/m2,scheduled to undergo elective surgeries under general anaesthesia with endotracheal intubation. Each subject’s anterior,lateral and posterior neck lengths (ANL,LNL,PNL) were measured pre operatively. Direct laryngoscopy was done to achieve the best Cormack Lehane(CL) grade using manoeuvres (Backward upward rightward manoeuvre(BURP)/OELM/Change of Blade/Change of pillow height/RAMP positioning) when indicated and the same compared to the measured neck lengths. RESULT : The incidence of difficult laryngoscopy was found to be 18 per cent in our study population. Anterior neck length in neutral position was found to be the best predictor of difficult laryngoscopy, with a threshold of less than or equal to 9 cms. No particular neck length correlated with BMI and age. All the neck lengths showed positive correlation with the height of the subject CONCLUSION : ANL with a cut off criterion of less than or equal to 9 cm in neutral position can used objectively when measuring neck length. All neck lengths showed significant change with neck mobility. Rate of change of both PNL and LNL with head extension position showed significant change in difficult laryngoscopy subjects.
前言:术前评估各种解剖和临床特征有助于提前识别潜在的困难喉镜检查和插管,使麻醉师为这种情况做好准备。虽然“短颈”是气道评估中常用的术语,表明气道困难的可能性。在喉镜下,切断值和不同颈部长度(前、后、外侧)之间的关系尚不清楚。目的:评估中立位和伸直位的前、后、侧颈长度,并将每项测量与喉镜下困难视图的预测相关联。材料与方法:本前瞻性观察研究纳入150例美国麻醉医师学会(ASA) 1/11级患者,年龄18-65岁,体重指数(BMI) 18- 35 kg/m2,计划在气管插管全麻下择期手术。术前测量每位受试者的前、侧、后颈部长度(ANL、LNL、PNL)。直接喉镜检查以达到最佳的Cormack Lehane(CL)等级,在指示时使用操作(向后向上右转操作(BURP)/OELM/改变刀片/改变枕头高度/RAMP定位),与测量的颈部长度相同。结果:在我们的研究人群中发现喉镜检查困难的发生率为18%。中性位前颈部长度是喉镜检查困难的最佳预测指标,阈值小于或等于9厘米。没有特定的颈部长度与BMI和年龄相关。结论:在测量颈长时,可以客观地采用中性位小于等于9 cm的ANL截断标准。所有颈部长度随颈部活动度的变化均有显著变化。在喉镜检查困难的患者中,PNL和LNL随头伸位的变化率均有显著变化。
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引用次数: 0
Serum Free Light Chain ratio: Utility as marker of residual disease in monoclonal gammopathies 血清游离轻链比值:作为单克隆丙种球蛋白病残留疾病标志物的实用性
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1673369494
Jayeeta Bhadra, S. Ansari, Meena Singh
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引用次数: 0
期刊
International Journal of Medical Reviews and Case Reports
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