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ATYPICAL INTERPRETATION OF MEDULLOBLASTOMA 髓母细胞瘤的不典型解释
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1671277484
R. Panda, Pratosh Paul, S. Mishra, S. Mishra
Introduction: Medulloblastoma is a midline posterior fossa mass that typically develops from the vermis in children. It shows up on a CT scan as a hyperdense, homogeneously enhancing mass and is linked to the clinical profile of posterior fossa syndrome. Although this distinct clinical-radiological pattern is regarded as "typical," medulloblastomas frequently do not follow the normal clinico-radiological pattern. Methods: To identify the abnormal clinical-radiological features, 28 patients were retrospectively analyzed and 12 cases were prospectively studied. Only 21 of the 40 patients showed the typical radiological feature of a hyperdense homogeneously enhancing mass, while the other four had hypodense nonenhancing masses, 12 had cystic alterations, and five had calcifications in their tumors. Three patients arrived with tumors in the cerebellopontine angle cistern, which is a rather rare position. Results: Patients who underwent follow-up for a minimum of 6 months and a maximum of 1 year returned with metastases in very odd places. There were 2 patients who had a cervical intramedullary metastasis, and there were 4 occurrences of metastases in the frontal and subfrontal area. One year following final surgery and ventriculoperitoneal shunting, abdominal metastases and ascites occurred in 3 individuals. But after surgery, each of these 3 patients had had a complete course of craniospinal irradiation. Conclusion: There were other cases that had atypical clinical, radiological, and metastatic patterns.
髓母细胞瘤是一种典型的儿童后窝中线肿块,起源于蚓部。CT扫描显示为高密度均匀增强肿块,与后窝综合征的临床表现有关。虽然这种独特的临床放射学模式被认为是“典型的”,但髓母细胞瘤经常不遵循正常的临床放射学模式。方法:对28例患者进行回顾性分析,并对12例患者进行前瞻性分析。40例患者中只有21例表现出典型的高密度均匀增强肿块,而其他4例为低密度非增强肿块,12例有囊性改变,5例肿瘤有钙化。3例患者到达时肿瘤位于桥小脑角池,这是一个相当罕见的位置。结果:随访时间最少6个月,最多1年的患者复发时转移部位非常奇怪。宫颈髓内转移2例,额叶及额下转移4例。在最后一次手术和脑室-腹膜分流后一年,3例发生腹腔转移和腹水。但在手术后,这3名患者都进行了完整的颅脊髓照射。结论:还有其他病例具有不典型的临床,放射学和转移模式。
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引用次数: 0
Lesser Omental Infarction Presenting with ST-Segment Changes on Electrocardiography in A 37-Year Old Male: Coincidence or Causation? 37岁男性小网膜梗死伴心电图st段改变:巧合还是因果关系?
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1684347260
Lila Hilal, Yumna Njoum, Suha Sulaiman, Bilal Adwan, Farah Jabbarin, S. Mtour
Background: Omental infarction is a rare cause of acute abdominal pain. While the clinical presentation and diagnostic workup of omental infarction have been well-described in the literature, there is currently no published data on the relationship between omental infarction and Electrocardiogram (ECG) changes. Case presentation: A 37-year-old male presented with acute onset of epigastric pain, He had associated ECG changes, including ST elevation in V1 (1 mm), ST depression in leads II, aVF, and V4 so he was diagnosed with omental infarction after exclusion of acute coronary syndrome (ACS) via cardiac catheterization and echocardiography. The patient was managed conservatively with pain control and close observation and was discharged home in stable condition, The ECG changes resolved on follow-up 2 weeks later. Conclusion: Omental infarction should be considered in the differential diagnosis of patients presenting with acute abdominal pain and ECG changes. Further studies are needed to elucidate the pathophysiology of ECG changes in omental infarction and to develop optimal management strategies for these patients.
背景:大网膜梗死是引起急性腹痛的罕见原因。虽然大网膜梗死的临床表现和诊断检查在文献中已经有很好的描述,但目前还没有关于大网膜梗死与心电图变化之间关系的公开数据。病例介绍:37岁男性,以急性上腹疼痛为主诉,心电图改变包括V1段ST段抬高(1mm),导联II段ST段、aVF段和V4段ST段下降,经心导管和超声心动图排除急性冠脉综合征(ACS)后诊断为大网膜梗死。患者经保守治疗,控制疼痛,严密观察,出院时病情稳定,随访2周后心电图改变消失。结论:急性腹痛和心电图改变患者应考虑大网膜梗死的鉴别诊断。需要进一步的研究来阐明大网膜梗死的病理生理变化,并为这些患者制定最佳的管理策略。
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引用次数: 0
Assessing visual symptoms related to dry eye and refractive error in school students before and after online classes during COVID-19 pandemic 评估学生在COVID-19大流行期间在线课程前后与干眼和屈光不正相关的视力症状
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1667489653
Dakin Paul, D. Rajan, D. Chokkalingam, Dr Gnaneswaran, Dr Matheen
Background: During the COVID-19 pandemic, there was a major change in the mode of education from offline to online classes for the school students. Objectives: To determine if school students have developed symptoms related to dry eye. Methodology: Its descriptive cross-sectional study. This study was conducted in a reputed school in the city and 1000 students who had attended online classes during the covid-19 pandemic by the Department of Ophthalmology, Chettinad hospital and research institute, Kelambakkam, Tamil nadu, India Results: About 41% experienced redness of eye, 38% experienced blurring of vision, 36.6% had eye pain, 32% had burning sensation of eyes signs of dryness of eye. 50.2% had adequate distance between your gadget and eyes, 36.1 % had too close to eyes and 13.7 % had too far from eyes. Regarding the eye checkup, 43.7% never checked up their eyes, 11.6% does annual examination and 44.7% does rarely. Comparison between duration of Electronic Gadget usage per day during online class and offline class was significantly reduced after the offline class commencement. P value is 0.000001. Conclusion: There is significant Digital screen exposure time difference is observed during online and in offline classes. And its impact in visual refractive errors and computer vision syndrome
背景:在新冠肺炎疫情期间,学校学生的教育模式发生了重大变化,从线下课程到线上课程。目的:确定在校学生是否出现与干眼症相关的症状。方法:描述性横断面研究。这项研究是在该市一所知名学校和1000名在2019冠状病毒病大流行期间参加过印度泰米尔纳德邦克拉姆巴卡姆切蒂纳德医院和研究所眼科部在线课程的学生中进行的。结果:约41%的人出现眼睛发红,38%的人出现视力模糊,36.6%的人出现眼睛疼痛,32%的人有眼睛灼烧感和眼睛干燥的迹象。50.2%的人认为电子产品与眼睛的距离足够,36.1%的人认为电子产品离眼睛太近,13.7%的人认为电子产品离眼睛太远。在眼科检查方面,43.7%从未检查过眼睛,11.6%每年检查一次,44.7%很少检查。在线上课和离线上课时,学生每天使用电子产品的时间比较,在离线上课后明显减少。P值为0.000001。结论:在线课堂与离线课堂存在显著的数字屏幕暴露时间差异。以及它对视觉屈光不正和计算机视觉综合症的影响
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引用次数: 0
A cross-sectional study in a tertiary care facility examined the prevalence, risk factors, mother health, and perinatal outcomes in eclampsia 一项在三级医疗机构开展的横断面研究探讨了子痫的发病率、风险因素、母亲健康和围产期结局
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1681728141
Gupteswar Mishra, S. Mohanty, Prabir Biswal
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引用次数: 0
Acute oleander poisoning treated successfully without Fab fragments- a case series and literature review 无Fab片段治疗急性夹竹桃中毒成功-个案系列及文献回顾
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1651109705
Prakash sanniboyina, thejaswi R, C. L., S. S
ABSTRACT Background- Nerium oleander (common oleander grown as an ornamental plant) and Cerbera Thevetia (yellow oleander grows wildly on the roadside). All parts of these plants, including nectar, are potentially lethal. Suicidal poisoning by the products of these plants is a toxicologic emergency in tropical and subtropical regions. They contain cardiac glycosides, namely Oleandrin, Oleandrigenin, Nerifolin, ThevetinA, and ThevetinB, which act like digoxin in addition to gastrointestinal symptoms. Ingestion of oleander results in nausea, vomiting, abdominal pain, diarrhoea, dysrhythmias, and hyperkalemia. Cardiac toxicity includes a variety of ventricular dysrhythmias and A-V Blocks, muscular twitching, tetanic spasms, lockjaw, coma and respiratory paralysis. The cause of death is usually cardiogenic shock and respiratory arrest. Some cases have been reported with acute kidney injury and hepatic damage. Case report – We have successfully managed 3 cases of acute oleander poisoning. All three patients were young and did not have comorbid conditions. 2 patients presented with mainly abdominal pain and vomiting and had hyperkalemia. The third patient had symptomatic bradycardia and several episodes of vomiting. Most cases can be managed by Multidose activated charcoal and supportive care with IV fluids and symptomatic treatment. Some patients require respiratory support, atropine and pacing for symptomatic bradycardia. Insulin-dextrose is the most effective method of treating hyperkalemia. Calcium chloride is contraindicated in this instance. Specific management is digoxin specific Fab fragments. As emergency physicians may encounter these cases, they should have sound knowledge about symptoms and management. Oleander poisoning should be considered in the differential for any young patient presenting with bradycardia.
摘要背景-夹竹桃(普通的观赏植物夹竹桃)和木犀草(黄色夹竹桃,在路边疯狂生长)。这些植物的所有部分,包括花蜜,都有潜在的致命性。在热带和亚热带地区,由这些植物的产物引起的自杀性中毒是一种突发毒理学事件。它们含有心脏糖苷,即夹竹桃苷、夹竹桃果苷、夹竹桃苷、夹竹桃苷和夹竹桃苷b,除了胃肠道症状外,它们的作用类似地高辛。摄入夹竹桃会导致恶心、呕吐、腹痛、腹泻、心律失常和高钾血症。心脏毒性包括各种室性心律失常和a - v传导阻滞、肌肉抽搐、强直性痉挛、闭锁、昏迷和呼吸麻痹。死亡原因通常是心源性休克和呼吸骤停。一些病例有急性肾损伤和肝损害的报道。个案报告-我们已成功处理3例急性夹竹桃中毒个案。所有三名患者均为年轻且无合并症。2例以腹痛、呕吐为主,伴有高钾血症。第三例患者有症状性心动过缓和几次呕吐。大多数病例可通过多剂量活性炭和支持性护理、静脉输液和对症治疗来处理。一些患者需要呼吸支持,阿托品和起搏治疗症状性心动过缓。葡萄糖胰岛素是治疗高钾血症最有效的方法。在这种情况下,氯化钙是禁忌的。特异性管理是地高辛特异性Fab片段。由于急诊医生可能会遇到这些病例,他们应该对症状和管理有充分的了解。夹竹桃中毒应考虑在鉴别任何年轻的病人表现为心动过缓。
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引用次数: 0
Life-threatening Hypercalcaemic Crisis Due to Benign Primary Hyperparathyroidism, a Case Report 由良性原发性甲状旁腺功能亢进引起的危及生命的高血钙危机1例报告
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1656142184
L. Castro, F. Coelho, R. Mendes, Andreia Silva, Leonor Santos
Primary Hyperparathyroidism (PHPT) is a frequent cause of hypercalcaemia and parathyroid adenoma is the most frequent aetiology. Most patients are now diagnosed incidentally or with slightly symptomatic disease, however PHPT can cause extremely elevated calcium levels leading to hypercalcaemic crisis, a life-threatening clinical scenario associated with calcium-related organ failure. We present a case of a woman with long-lasting neuropsychiatric symptoms caused by PHPT, misdiagnosed as a depressive syndrome, which ultimately develops hypercalcaemic crisis. After parathyroidectomy, patient fully recovered organ failure and previous depressive symptoms within six months. Early diagnosis, adequate resuscitation and organ support associated with parathyroidectomy can lead to a better prognosis in comparison with the elevated mortality reported in the past.
原发性甲状旁腺功能亢进(PHPT)是高钙血症的常见原因,甲状旁腺瘤是最常见的病因。大多数患者现在被诊断为偶然或有轻微症状的疾病,然而,PHPT可引起钙水平极高,导致高钙血症危象,这是一种危及生命的临床情景,与钙相关的器官衰竭有关。我们提出一个病例的妇女长期神经精神症状引起的PHPT,误诊为抑郁综合征,最终发展高钙血症危机。甲状旁腺切除术后,患者在六个月内完全恢复了器官衰竭和先前的抑郁症状。早期诊断,充分的复苏和器官支持与甲状旁腺切除术相关,与过去报道的高死亡率相比,可以带来更好的预后。
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引用次数: 0
ELECTROCARDIOGRAM PATTERN PRE AND 24 HOURS POST THERAPY IN HYPONATREMIA WITH HEART FAILURE PATIENT 低钠血症合并心力衰竭患者治疗前后24小时的心电图特征
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1671075092
Iswina Baharuddin, Pendrik Tandean, Idar Mappangara, S. Bakri, H. Rasyid, A. Aman, A. Seweng
Background : Hyponatremia is the most common electrolyte disturbance in hospitalized heart failure patients, with a prevalence of around 19%-25%. The relationship between hyponatremia and cardiac conduction disorders has not been demonstrated yet. When there is a decrease in extracellular Na+ levels, there is a delay in the depolarization phase. This study was conducted to observe the ECG pattern in hyponatremic patients with heart failure (particularly in the P wave, PR interval, and QRS complex) and ECG changes after 24 hours of therapy. Methode: This study used a longitudinal observational descriptive method. Patients who were included in this study were hyponatremic patients with heart failure at the Wahidin Sudirohusodo Hospital Makassar from April to September 2021. The patient's electrocardiogram data when first admitted and after 24 hours of therapy. Statistical test using McNemar and Wilcoxon Signed Rank Test, where the test results are statistically significant when the p value <0.05. Result : This study included 51 subjects with a distribution of 68.6% men with an age range of 18-85 years. Pre-therapy ECG pattern showed 12 patients with prolonged P-R interval, and 4 patients with widening of the QRS complex. After 24 hours of therapy, 12 people became normonatremia and the mean P wave and P-R interval were lower than pre-therapy, while the QRS complex did not show any changes. Conclusion : The ECG pattern in hyponatremia with heart failure are prolonged P-R interval and widening of the QRS complex, but the ECG changes were not significant to Na+ levels changes.
背景:低钠血症是住院心力衰竭患者中最常见的电解质紊乱,患病率约为19%-25%。低钠血症与心脏传导障碍之间的关系尚未得到证实。当细胞外Na+水平降低时,去极化期延迟。本研究旨在观察低钠血症合并心力衰竭患者在治疗24小时后的心电图模式(特别是P波、PR间期和QRS复合体)及心电图变化。方法:本研究采用纵向观察描述性方法。本研究纳入的患者是2021年4月至9月在望加锡Wahidin Sudirohusodo医院就诊的低钠血症心力衰竭患者。患者入院时和治疗24小时后的心电图数据。统计检验采用McNemar and Wilcoxon sign Rank检验,当p值<0.05时,检验结果具有统计学意义。结果:本研究纳入51例受试者,年龄在18-85岁之间,男性占68.6%。治疗前心电图显示12例P-R间期延长,4例QRS复合物增宽。治疗24小时后,12例患者变为正常血钠,平均P波和P- r间期均低于治疗前,而QRS复合体无变化。结论:低钠血症合并心力衰竭的心电图表现为P-R间期延长、QRS复合体增宽,但心电图变化与Na+水平变化无显著性关系。
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引用次数: 0
Syndrome de démyélinisation osmotique : à propos de deux cas (typique et moins typique) et revue de la littérature 渗透脱髓鞘综合征:约2例(典型和不典型)和文献综述
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1682337735
Hanane Mouden, G. Lembarki, Sami Himri, M. Labied, M. Sabiri, S. Lezar, F. Essodegui
Le syndrome de démyélinisation osmotique (SDO) ou la myélinolyse centropontine et extrapontine correspond à un état neurologique sévère traduisant une démyélinisation axonale, localisée le plus souvent au niveau pontique, secondaire le plus souvent à une correction rapide d’une hyponatrémie. L’IRM joue un rôle essentiel dans le diagnostic positif et différentiel. Nous présentons deux cas de syndrome de démyélinisation osmotique, hospitalisés pour coma non fébrile. Nos deux cas étaient de sexe féminin avec des âges de 63 et 30 ans. L'évolution a été marquée par l'aggravation neurologique avec trouble de conscience et déficit moteur. Le diagnostic a été confirmé par une imagerie par résonance magnétique encéphalique. Le SDO chez le premier cas a fait suite à une correction rapide de l'hyponatrémie alors que chez le 2ème cas, le SDO est survenu dans un contexte d’hypokaliémie seule qui représente un facteur favorisant de ce syndrome. Le traitement a été principalement basé sur la correction de l’hypokaliémie et la correction prudente de l’hyponatrémie. L’association du syndrome de démyélinisation osmotique avec la correction rapide de l’hyponatrémie est bien connue. Toutefois l’implication de l’hypokaliémie dans la pathogénèse de ce syndrome est rarement rapportée dans la littérature.
渗透脱髓鞘综合征(dos)或centropontine和extrapontine髓鞘溶解是一种严重的神经系统疾病,导致轴突脱髓鞘,通常局限于pontic水平,通常继发于低钠血症的快速纠正。mri在阳性和鉴别诊断中起着至关重要的作用。我们报告了两例渗透脱髓鞘综合征,因非发热性昏迷住院。我们的两例患者均为女性,年龄分别为63岁和30岁,表现为神经系统恶化,伴有意识障碍和运动障碍。脑磁共振成像证实了诊断。在第一例中,do发生在低钠血症的快速纠正之后,而在第二例中,do发生在低钾血症的背景下,这是该综合征的一个促进因素。治疗主要以纠正低钾血症和谨慎纠正低钠血症为基础。渗透脱髓鞘综合征与低钠血症的快速纠正之间的联系是众所周知的。然而,低血钾在该综合征发病机制中的作用在文献中很少报道。
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引用次数: 0
A Rare Case of Testicular Infarction Secondary to Epididymo-Orchitis in a Patient with Spinal Cord Injury 脊髓损伤患者继发于附睾-睾丸炎的睾丸梗死一例
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1671082952
V. Chang, Tiffany Ho, Q. Ho, K. Leong
There has been an increasing number of reported cases of testicular infarction secondary to epididymo-orchitis in recent years. However, the occurrence of this in those with spinal cord injuries has rarely been reported. This population of patients have a higher prevalence of epididymo-orchitis and due to altered or absent nociceptive perception, evaluation of their progression to testicular infarction can be difficult, leading to unnecessary delay for surgical management. We present a case of epididymo-orchitis in a patient with C5/6 complete spinal cord injury whose clinical course was complicated by testicular infarction requiring left orchidectomy. This case highlights those with spinal cord injuries may benefit from increased vigilance, more frequent imaging surveillance and consideration of adjunct imaging modalities to monitor the progression of epididymo-orchitis and facilitate earlier diagnosis of complications.
近年来,有越来越多的病例报道继发于附睾睾丸炎的睾丸梗死。然而,这种情况在脊髓损伤患者中很少有报道。这类患者有较高的附睾睾丸炎患病率,由于伤害性知觉改变或缺失,评估其进展为睾丸梗死可能很困难,导致不必要的手术治疗延迟。我们报告一例伴有C5/6完全性脊髓损伤的附睾睾丸炎患者,其临床过程并发睾丸梗死,需要左侧睾丸切除术。本病例强调,脊髓损伤患者可以提高警惕,更频繁地进行影像学监测,并考虑辅助影像学方式来监测附睾-睾丸炎的进展,并促进并发症的早期诊断。
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引用次数: 0
A case series of Extra-peritoneal spread of perianal abscess: a rare complication of perianal abscess - Experience from a tertiary care centre in India. 一个病例系列的腹膜外扩散的肛周脓肿:一个罕见的并发症的肛周脓肿-经验从三级保健中心在印度。
Pub Date : 2023-01-01 DOI: 10.5455/ijmrcr.172-1663568473
G. S, Paul D, Titus K, Beulah Roopavathana, S. Chase
Extra-peritoneal spread of perianal abscess is a rare form of anorectal disease responsible for significant morbidity. We present a case series of 10 patients who presented with abdominal pain as a common symptom. 9 of 10 were not diagnosed at presentation to index centre. A proper examination of the perianal region as well as abdomen can help us suspect this condition clinically and can be confirmed with cross sectional imaging. Draining seton with adequate drainage of both perianal and extra-peritoneal component is the key treatment.
摘要腹膜外扩散的肛周脓肿是一种罕见的肛肠疾病,发病率极高。我们提出了一个病例系列的10例患者谁提出腹痛作为一个共同的症状。10例中有9例在就诊时未被诊断。对肛周和腹部进行适当的检查可以帮助我们在临床上怀疑这种情况,并可以通过横断成像得到证实。肛门周围和腹膜外部分的引流是关键的治疗方法。
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引用次数: 0
期刊
International Journal of Medical Reviews and Case Reports
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