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Development and characterization of chitosan-pluronic nanoparticles for tamoxifen delivery and cytotoxicity to MCF-7 cells 壳聚糖-pluronic纳米颗粒的开发和表征及其对MCF-7细胞的细胞毒性
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609328
Rajath Othayoth, V. Karthik, K. Santhosh Kumar
In this study, tamoxifen-loaded chitosan-pluronic nanoparticles have been prepared by an ionic gelation (IG) method. Particle size analysis, Scanning electron microscopy (SEM), Zeta potential measurements, Fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) were used for nanoparticle characterization. The cytotoxicity of the nanoparticles was assayed in the MCF-7 cell line. The optimized tamoxifen loaded nanoparticles had a spherical shape with positive charge and mean diameter 150 to 300 nm. The FT-IR and DSC studies found that the drug was dispersed in amorphous form due to its potent interaction with nanoparticles matrix. The maximum encapsulation efficiency was obtained at 8mg/ml tamoxifen. The tamoxifen loaded chitosan-pluronic nanoparticles had good blood compatibility and the particles were nontoxic to the MCF-7 cell line. All study results suggest that the nanoparticles could be used as an effective drug delivery carrier for the breast cancer treatment.
本研究采用离子凝胶(IG)法制备了负载他莫昔芬的壳聚糖pluronic纳米颗粒。采用粒度分析、扫描电镜(SEM)、Zeta电位测量、傅里叶变换红外光谱(FT-IR)和差示扫描量热法(DSC)对纳米颗粒进行表征。在MCF-7细胞系中测定了纳米颗粒的细胞毒性。优化后的负载他莫昔芬的纳米颗粒呈球形,带正电荷,平均直径为150 ~ 300 nm。FT-IR和DSC研究发现,由于药物与纳米颗粒基质的有效相互作用,药物以无定形分散。他莫昔芬在8mg/ml时包封率最高。负载他莫昔芬的壳聚糖pluronic纳米颗粒具有良好的血液相容性,对MCF-7细胞系无毒。所有的研究结果表明,纳米颗粒可以作为一种有效的药物递送载体用于乳腺癌的治疗。
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引用次数: 3
Biosynthesis and characterization of gold nanoparticles using plant extracts 利用植物提取物合成金纳米颗粒及其表征
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609296
N. Sane, B. Hungund, N. Ayachit
Here is an effort to present the rapid, reliable and eco-friendly synthesis of gold nanoparticles (GNPs) by green biogenic approach. The method uses aqueous extracts of Betel leaf, Hibiscus leaf, Lantana camara and nuts of bitter guard as reducing as well as stabilizing agent. Gold nanoparticles were synthesized by thermal reduction (microwave irradiation) of chloroauric acid (HAuCl4) using aqueous extracts of plant materials mentioned above. The formation of gold nanoparticles was confirmed by using UV-Visible spectra. Gaussian curves with absorbance peaks were obtained between 500 nm to 600 nm which confirms to similar previous investigations. Bioreduction of 0.5 mM and 1mM HAuCl4 by varying gold salt and extract ratio were investigated. Approximate sizes of synthesized GNPs were predicted using Mie Plot software according to which they vary in the range of 26-63nm.
本文介绍了利用绿色生物源方法快速、可靠、环保地合成金纳米颗粒的方法。该方法以槟榔叶、芙蓉叶、山楂叶和苦保果的水提物为还原剂和稳定剂。以上述植物材料的水提物为原料,采用热还原(微波辐照)法制备了金纳米颗粒。利用紫外可见光谱证实了金纳米颗粒的形成。在500 ~ 600 nm范围内得到了吸光度峰的高斯曲线,与前人的研究结果一致。研究了不同金盐和浸提比对0.5 mM和1mM HAuCl4的生物还原效果。利用Mie Plot软件预测了合成GNPs的大致尺寸,它们在26-63nm范围内变化。
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引用次数: 3
Ruthenium oxide - single walled carbon nanotube composite based high energy supercapacitor 氧化钌-单壁碳纳米管复合材料基高能超级电容器
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609338
N. Jha, E. Bekyarova, P. Ramesh, M. Itkis, R. Haddon
Ruthenium oxide (RuO2) nanoparticles were supported on the outer surface of single walled carbon nanotubes (SWNTs) using chemical reduction technique. The nanocomposite was employed as an electrode material for charge storage capacitor using ionic liquid, 1-ethyl-3-methylimidazolium tetrafluoroborate electrolyte solution. The electrochemical charge storage properties of the composite were investigated using two electrode cyclic voltammetry and galvanostatic charge-discharge techniques. The specific capacitance and energy density of the RuO2-SWNT nanocomposite electrode material based on the fabricated coin cell supercapacitor were measured to be as high as 174 F/g and 74 Wh/kg at current density of 1 A/g.
采用化学还原技术将氧化钌纳米颗粒负载在单壁碳纳米管(SWNTs)的外表面。采用离子液体1-乙基-3-甲基咪唑四氟硼酸盐电解质溶液,将该纳米复合材料作为电荷存储电容器的电极材料。采用双电极循环伏安法和恒流充放电技术研究了复合材料的电化学电荷存储性能。在电流密度为1 A/g时,基于硬币电池超级电容器制备的RuO2-SWNT纳米复合电极材料的比电容和能量密度分别高达174 F/g和74 Wh/kg。
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引用次数: 4
Heat transfer characteristics of acetone/water mixture in a tubular heat exchanger with turbulator 带有紊流器的管式换热器中丙酮/水混合物的换热特性
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609370
Baskar, Karthikeyan.
The main objective of the paper is to study the thermo-physical properties of acetone/water mixture as a function of a different volume fraction at the different operating temperatures. This paper deals with the study on the acetone/water mixture, mainly the enhancement of heat transfer co-efficient, thermo-physical properties such as thermal conductivity, specific heat and viscosity. The thermo-physical properties play a major role for the heat transfer enhancement. The experimental set up will lead to more heat transfer applications in future.
本文的主要目的是研究丙酮/水混合物在不同操作温度下不同体积分数的热物理性质。本文主要对丙酮/水混合物的传热系数、导热系数、比热和粘度等热物性的提高进行了研究。热物理性质对强化传热起主要作用。该实验装置将在未来带来更多的传热应用。
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引用次数: 12
Physical properties of nanoscale TiO2 with mild rare earth ion doping 温和稀土离子掺杂纳米TiO2的物理性质
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609268
N. Paul, D. Mohanta
In this report, we present the spectroscopic features of nanostructured undoped and RE (rare earth) doped TiO2 system. Undoped an RE doped TiO2 nanostructures were fabricated using conventional sol-gel method. The structural properties of synthesized nanostructures were characterized by X-ray diffractrogram (XRD) and high resolution transmission electron microscopy (HRTEM). XRD spectra shows the anatase phase of TiO2 in all the spectra and HRTEM image shows ~ 7nm particle size for the all the samples. The spectroscopic properties were studied by UV-Visible spectroscopy, Fourier transformed infrared spectroscopy and photoluminescence spectroscopy. The emissions due to color centers and oxygen vacancies of TiO2 were also evident in the PL spectra. The luminescent property of Tb and Eu-doped TiO2 samples has been studied and it showed selected D-F transition. A weak emission peak at ~490 and ~544 nm corresponding to 5D47F6,5 transition of Tb3+. Whereas Eu doped TiO2 nanoparticles exhibited different intra 4f Eu3+ ion related transitions with the most intense red emission (5D07F2) peak observable at ~613 nm.
在本报告中,我们介绍了纳米结构的未掺杂和稀土掺杂TiO2体系的光谱特征。采用溶胶-凝胶法制备了未掺杂和稀土掺杂的TiO2纳米结构。利用x射线衍射仪(XRD)和高分辨率透射电镜(HRTEM)对合成的纳米结构进行了表征。XRD谱图均显示TiO2为锐钛矿相,HRTEM谱图均显示TiO2粒径为~ 7nm。采用紫外可见光谱、傅里叶变换红外光谱和光致发光光谱对其光谱特性进行了研究。在PL光谱中,TiO2的色心和氧空位的发射也很明显。对Tb和eu掺杂TiO2样品的发光特性进行了研究,发现其具有选择性的D-F跃迁。在~490和~544 nm处有弱发射峰,对应于Tb3+的5D4→7f6,5跃迁。而Eu掺杂TiO2纳米粒子表现出不同的4f内Eu3+相关跃迁,在~613 nm处可观察到最强烈的红色发射峰(5D0→7F2)。
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引用次数: 2
Studies on transport properties of CdO-CuO thin film hetero junction CdO-CuO薄膜异质结输运性质研究
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609347
C. Debnath, K. L. Bhowmi, B. Sah
Thin film of CuO and CdO were prepared for making heterojunction. The films were prepared by radio frequency magnetron sputtering technique. The junction shows outstanding electrical properties and particularly the electrical properties of CuO were found to be highly effected and enhanced. Carrier diffusion and carrier tunnelling through the interface potential lead to the outstanding electrical properties of the heterojunction. These types of heterostructures are potential candidate for different device applications such as field emission display and optoelectronic devices.
制备了CuO和CdO薄膜用于异质结的制备。采用射频磁控溅射技术制备薄膜。该结具有优异的电学性能,特别是氧化铜的电学性能得到了很大的影响和提高。载流子扩散和通过界面电位的载流子隧穿导致异质结具有优异的电学性能。这些类型的异质结构是不同器件应用的潜在候选者,如场发射显示和光电子器件。
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引用次数: 1
Structural and magnetic properties of Co0.5Cd0.5Fe2O4 nano ferrite particles Co0.5Cd0.5Fe2O4纳米铁氧体颗粒的结构和磁性能
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609271
B. Narendra, D. Bhaskar, G. Srinivas, R. Ravikumar, C. V. Reddy
Cobalt Cadmium Ferrite, Co0.5Cd0.5Fe2O4 nanoferrite powder with the suitable stoichiometric ratio was prepared by using co-precipitation method. As prepared sample was characterized by using powder X-ray diffraction (XRD), Scanning Electron Microscope with EDX and Vibrating sample magnetometer (VSM). At room temperature the specific saturation magnetization (MS) of the prepared material was measured. From the powder XRD data, the average crystallite size was calculated. SEM images showed the surface morphology of prepared nanoferrite sample along with chemical mapping.
采用共沉淀法制备了化学计量比合适的钴镉铁氧体、Co0.5Cd0.5Fe2O4纳米铁氧体粉末。采用粉末x射线衍射仪(XRD)、扫描电镜(EDX)和振动样品磁强计(VSM)对制备的样品进行了表征。在室温下测定了所制备材料的比饱和磁化强度(MS)。根据粉末的XRD数据,计算了平均晶粒尺寸。SEM图像显示了制备的纳米铁氧体样品的表面形貌和化学作图。
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引用次数: 0
Security attacks and their countermeasures along with node replication attack for time synchronization in wireless sensor network 无线传感器网络时间同步的安全攻击与节点复制攻击
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609369
S. Umrao, Arun Kumar, Praveet Umrao
Wireless sensor network (WSN) is a group of interconnected sensor nodes, usually broaden out in areas which are not easily accessible and communicate wirelessly. A sensor node is capable to sense environment, communicate the gather information to another nodes and also have computing power. The use of ubiquitous wireless sensor networks has increased the complexity day by day to identify wireless sensor network attacks and there countermeasures. In this paper, different types of vulnerabilities associated with WSN and their effects, countermeasures are discussed.
无线传感器网络(WSN)是一组相互连接的传感器节点,通常在不容易到达的区域进行无线通信。传感器节点能够感知环境,将采集到的信息传递给其他节点,并具有计算能力。无处不在的无线传感器网络的使用日益增加了识别无线传感器网络攻击及其应对措施的复杂性。本文讨论了无线传感器网络中存在的不同类型的漏洞及其影响和应对措施。
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引用次数: 6
Studies on DC reactive magnetron sputtered CdO:C thin films for optoelectronic devices 光电器件用直流反应磁控溅射CdO:C薄膜的研究
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609305
B. Hymavathi, B. Rajesh Kumar, T. Subba Rao
Cr doped CdO thin films were deposited on glass substrates by DC reactive magnetron sputtering method with individual Cd and Cr metallic targets. The effect of Cr concentration (1% to 5%) on structural, electrical and optical properties of CdO films was investigated. The structural studies reveal that the films are polycrystalline with preferred orientation along (2 0 0) plane. The shift of the diffraction peak (2 0 0) towards higher angles with the increase of Cr concentration indicates the presence of stress in the films. SEM images consist of agglomerates and no distinguished grains are seen. Energy Dispersive Analysis of X-rays (EDAX) is carried out for the compositional analysis of prepared thin films. The optical transmittance of 85 % and minimum resistivity of 1.73 × 10-4 Ω.cm is obtained for 3% Cr doped CdO thin films. A blue shift of the band edge has been observed for the Cr doped CdO films with the increase of Cr Concentration. This blue shift is due to Burstein -Moss effect, which arises due to increase in free carrier concentration. The optical band gap of Cr doped CdO thin films increases from 2.35 to 2.85 eV with the increase of Cr concentration. The optical constants such as absorption coefficient (a), extinction coefficient (k) and refractive index (n) were determined from the optical transmission data.
采用直流反应磁控溅射的方法在玻璃衬底上沉积了掺杂Cr的CdO薄膜。研究了Cr浓度(1% ~ 5%)对CdO膜结构、电学和光学性能的影响。结构研究表明,薄膜是沿(2 ~ 0)平面择优取向的多晶。随着Cr浓度的增加,衍射峰(2 0 0)向更高角度移动表明薄膜中存在应力。扫描电镜图像由团块组成,未见明显的颗粒。利用x射线能量色散分析(EDAX)对制备的薄膜进行成分分析。透光率85%,最小电阻率1.73 × 10-4 Ω。在3% Cr掺杂的CdO薄膜中得到cm。随着Cr浓度的增加,Cr掺杂的CdO薄膜的带边出现了蓝移。这种蓝移是由于自由载流子浓度的增加而引起的伯斯坦-莫斯效应。随着Cr浓度的增加,Cr掺杂CdO薄膜的光学带隙从2.35 eV增加到2.85 eV。根据光传输数据测定了吸收系数(a)、消光系数(k)和折射率(n)等光学常数。
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引用次数: 0
ZnO nanowire based piezo and photoelectric effects coupled nanogenerator 基于ZnO纳米线的压电光电效应耦合纳米发电机
Pub Date : 2013-07-24 DOI: 10.1109/ICANMEET.2013.6609334
A. Kathalingam, J. Rhee
This report describes fabrication of ZnO nanowire based nanogenerator used to simultaneously harvest both light and ambient mechanical vibration. The ZnO nanowires used in this work were grown on p-type Si substrates employing seed mediated low-temperature aqueous solution method. Using the synthesized ZnO nanowire and conducting ITO plate a sandwich type ITO/n-ZnO NW/p-Si cell was fabricated and its ability in simultaneous harvesting of light and mechanical energy has been studied. This design of piezoelectric and photoelectric hybrid nanogenerator is first of this kind of devices ever fabricated to harvest more than one type of ambient energy.
本报告描述了基于ZnO纳米线的纳米发电机的制造,用于同时收集光和环境机械振动。本文采用低温水溶液法在p型Si衬底上生长ZnO纳米线。利用合成的ZnO纳米线和导电ITO板制备了夹芯型ITO/n-ZnO NW/p-Si电池,并对其同时收集光能和机械能的能力进行了研究。这种压电和光电混合纳米发电机的设计是有史以来第一次制造这种装置来收集多种类型的环境能量。
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引用次数: 2
期刊
International Conference on Advanced Nanomaterials & Emerging Engineering Technologies
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