首页 > 最新文献

International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)最新文献

英文 中文
Imaging with a steerable photonic nanojet probe 可操纵光子纳米射流探针成像
M. Karamehmedović, Kenneth Scheel, F. Pedersen, P. Hansen
The lateral and vertical resolution in conventional optical microscopy is restricted by fundamental diffraction limits. One direction towards super-resolution optical microscopy is the use of photonic nanojets (PNJs) for sample illumination. Here, the aim is to exploit the high spatial localization of PNJs to allow measurements of sub-classical particles and features in spite of their small size compared to the operating wavelength. The applications of super-resolution methods include fluorescence and Raman microscopy, scatterometric measurements, and optical imaging. As a step towards PNJ scanning microscopy, we here apply our recently proposed method for fast and precise steering of PNJs over a large dynamical range in the near field. In a proof-of-concept computation, we use the steerable optical probe to extract information on structures beyond the classical lateral and vertical resolution limits.
传统光学显微镜的横向和纵向分辨率受基本衍射极限的限制。超分辨率光学显微镜的一个方向是使用光子纳米射流(PNJs)进行样品照明。在这里,目的是利用PNJs的高空间定位,尽管它们的尺寸与工作波长相比很小,但仍可以测量亚经典粒子和特征。超分辨率方法的应用包括荧光和拉曼显微镜、散射测量和光学成像。作为向PNJ扫描显微镜迈出的一步,我们在这里应用我们最近提出的方法在近场大动态范围内快速精确地转向PNJ。在概念验证计算中,我们使用可操纵的光学探针来提取超出经典横向和垂直分辨率限制的结构信息。
{"title":"Imaging with a steerable photonic nanojet probe","authors":"M. Karamehmedović, Kenneth Scheel, F. Pedersen, P. Hansen","doi":"10.1117/12.2633442","DOIUrl":"https://doi.org/10.1117/12.2633442","url":null,"abstract":"The lateral and vertical resolution in conventional optical microscopy is restricted by fundamental diffraction limits. One direction towards super-resolution optical microscopy is the use of photonic nanojets (PNJs) for sample illumination. Here, the aim is to exploit the high spatial localization of PNJs to allow measurements of sub-classical particles and features in spite of their small size compared to the operating wavelength. The applications of super-resolution methods include fluorescence and Raman microscopy, scatterometric measurements, and optical imaging. As a step towards PNJ scanning microscopy, we here apply our recently proposed method for fast and precise steering of PNJs over a large dynamical range in the near field. In a proof-of-concept computation, we use the steerable optical probe to extract information on structures beyond the classical lateral and vertical resolution limits.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82978258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Layer by layer thin film fabrication with in-process laser patterning 一层一层的薄膜制造过程中的激光图像化
K. Leake, Alexandria Carter, H. Yochum
A modification of the traditional layer by layer process where the substrate is irradiated with laser light during the polycation and/or polyanion dipping cycles is described. By adjusting the laser irradiation time during dipping, irradiation power, number of bilayers, and the location and speed of laser irradiation, a variety of structures with controlled thicknesses can be fabricated. Laser patterned multilayer PAH/PTEBS polymer thin films were fabricated and characterized with absorbance mapping to demonstrate several patterning approaches. Results for 1) two laser patterned tracks, 2) single laser patterned track with varied average laser power across the sample from a continuously variable neutral density filter, and 3) laser patterning using a beam sent through multiple circular apertures are described. Based on the variable neutral density filter laser pattern, for 20 bilayer PAH/PTEBS films, an absorbance difference between off and on pattern of 0.1 requires an average laser power of less than 15 mW at 405 nm. The patterns produced are on the scale of several millimeters, though they could be made much smaller by focusing the laser used for patterning.
本文描述了对传统的一层一层工艺的改进,其中在多阳离子和/或聚阴离子浸渍循环期间用激光照射衬底。通过调整浸渍时的激光照射时间、照射功率、双层层数以及激光照射的位置和速度,可以制备出各种厚度可控的结构。制备了激光图像化的多层PAH/PTEBS聚合物薄膜,并用吸光度映射法对其进行了表征。描述了1)两个激光图图化轨迹,2)连续可变中性密度滤波器在样品上具有不同平均激光功率的单激光图图化轨迹,以及3)使用通过多个圆孔发送的光束进行激光图图化的结果。基于可变中性密度滤波器的激光模式,对于20层双层PAH/PTEBS薄膜,关闭和打开模式之间的吸光度差为0.1,需要在405 nm处的平均激光功率小于15 mW。所产生的图案在几毫米的尺度上,尽管它们可以通过聚焦用于图案的激光而变得更小。
{"title":"Layer by layer thin film fabrication with in-process laser patterning","authors":"K. Leake, Alexandria Carter, H. Yochum","doi":"10.1117/12.2632090","DOIUrl":"https://doi.org/10.1117/12.2632090","url":null,"abstract":"A modification of the traditional layer by layer process where the substrate is irradiated with laser light during the polycation and/or polyanion dipping cycles is described. By adjusting the laser irradiation time during dipping, irradiation power, number of bilayers, and the location and speed of laser irradiation, a variety of structures with controlled thicknesses can be fabricated. Laser patterned multilayer PAH/PTEBS polymer thin films were fabricated and characterized with absorbance mapping to demonstrate several patterning approaches. Results for 1) two laser patterned tracks, 2) single laser patterned track with varied average laser power across the sample from a continuously variable neutral density filter, and 3) laser patterning using a beam sent through multiple circular apertures are described. Based on the variable neutral density filter laser pattern, for 20 bilayer PAH/PTEBS films, an absorbance difference between off and on pattern of 0.1 requires an average laser power of less than 15 mW at 405 nm. The patterns produced are on the scale of several millimeters, though they could be made much smaller by focusing the laser used for patterning.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79942711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of substrate to culture and image live cells for surface plasmon microscopy 表面等离子体显微镜活细胞培养和成像基质的优化
Ipsita Chakraborty, Daiki Matsubayashi, Tomoki Omachi, Yasushi Hasegawa, H. Kano
In this proceeding, we search an optimized substrate for live cell imaging in culture medium with surface plasmon microscopy with high sensitivity. Coverslips coated with nano-metric bimetallic gold and silver best serves the purpose.
在本研究中,我们利用高灵敏度的表面等离子体显微镜在培养基中寻找一种优化的活细胞成像底物。涂有纳米双金属金和银的盖片最能满足这一目的。
{"title":"Optimization of substrate to culture and image live cells for surface plasmon microscopy","authors":"Ipsita Chakraborty, Daiki Matsubayashi, Tomoki Omachi, Yasushi Hasegawa, H. Kano","doi":"10.1117/12.2637472","DOIUrl":"https://doi.org/10.1117/12.2637472","url":null,"abstract":"In this proceeding, we search an optimized substrate for live cell imaging in culture medium with surface plasmon microscopy with high sensitivity. Coverslips coated with nano-metric bimetallic gold and silver best serves the purpose.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89344869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep reinforcement learning with artificial microswimmers 人工微游泳者的深度强化学习
Ravi Pradip, F. Cichos
Artificial microswimmers are active particles designed to mimic the behavior of living microorganisms. The adaptive behavior of the latter is based on the experience they gain through interactions with the environment. They are also subjected to Brownian motion at these length scales which randomizes their position and propulsion direction making it a key feature in the adaptation process. However, artificial systems are limited in their ability to adapt to such noise and environmental stimuli. In this work, we combine artificial microswimmers with a reinforcement learning algorithm to explore their adaptive behavior in a noisy environment. These self-thermophoretic active particles are propelled and steered by generating thermal gradients on their surface with a tightly focused laser beam. They are also imaged under a microscope in real-time to monitor their dynamics. With such a versatile platform capable of real-time control and monitoring, we demonstrated the solution to a standard navigation problem under the inevitable influence of Brownian motion by introducing deep reinforcement learning, specifically deep-Q-learning. We also identified different noises in the system and how they affected the learning speed and navigation strategies picked up by the microswimmer.
人造微游泳者是设计用来模仿活微生物行为的活性粒子。后者的适应性行为是基于它们通过与环境的相互作用而获得的经验。它们在这些长度尺度上也受到布朗运动的影响,这使得它们的位置和推进方向随机化,使其成为适应过程中的一个关键特征。然而,人工系统在适应这种噪声和环境刺激方面的能力有限。在这项工作中,我们将人工微游泳者与强化学习算法结合起来,探索它们在嘈杂环境中的自适应行为。这些自热电泳活性粒子是通过在其表面产生热梯度,用紧密聚焦的激光束来推进和操纵的。在显微镜下对它们进行实时成像,以监测它们的动态。有了这样一个能够实时控制和监测的多功能平台,我们通过引入深度强化学习,特别是深度q学习,展示了在布朗运动不可避免的影响下标准导航问题的解决方案。我们还确定了系统中不同的噪音,以及它们如何影响微游泳者的学习速度和导航策略。
{"title":"Deep reinforcement learning with artificial microswimmers","authors":"Ravi Pradip, F. Cichos","doi":"10.1117/12.2633774","DOIUrl":"https://doi.org/10.1117/12.2633774","url":null,"abstract":"Artificial microswimmers are active particles designed to mimic the behavior of living microorganisms. The adaptive behavior of the latter is based on the experience they gain through interactions with the environment. They are also subjected to Brownian motion at these length scales which randomizes their position and propulsion direction making it a key feature in the adaptation process. However, artificial systems are limited in their ability to adapt to such noise and environmental stimuli. In this work, we combine artificial microswimmers with a reinforcement learning algorithm to explore their adaptive behavior in a noisy environment. These self-thermophoretic active particles are propelled and steered by generating thermal gradients on their surface with a tightly focused laser beam. They are also imaged under a microscope in real-time to monitor their dynamics. With such a versatile platform capable of real-time control and monitoring, we demonstrated the solution to a standard navigation problem under the inevitable influence of Brownian motion by introducing deep reinforcement learning, specifically deep-Q-learning. We also identified different noises in the system and how they affected the learning speed and navigation strategies picked up by the microswimmer.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81647114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated photonic-electronic platform for real-time analog data processing in LiDARs 激光雷达实时模拟数据处理集成光电子平台
Mahsa Salmani, Sreenil Saha, A. Eshaghi
Light, detection and ranging (LiDAR), has been emerging as a powerful tool for applications with accurate and reliable perception requirements, e.g., autonomous driving which needs a combination of long-range and high spatial resolution together with a real-time performance. Processing the raw LiDAR data, which is a large-dimensional unstructured 3D point cloud, is computationally costly due to the nature of the algorithms used for processing the point clouds. In particular, the neural networks employed for LiDAR data processing comprise several layers, for each of which multiplications of matrices with large sizes need to be performed. In this case, graphics processing units (GPUs) cannot be used as real-time standalone devices for hardware acceleration because they have high execution time due to their dependency on a central processing unit (CPU) for data offloading and scheduling the execution of the algorithms used to process point clouds. To address the aforementioned challenges, we propose an efficient co-design of an analog neural network (ANN) and a hybrid CMOS-Photonics platform for LiDAR systems. The proposed architecture exploits the high bandwidth and low latency of optical computation to significantly improve the computational efficiency. In particular, in our proposed architecture, a CMOS control chip integrated with a photonic broadcast-and-weight architecture is interfaced with LiDAR to perform real-time data processing and high-dimensional matrix multiplications. Moreover, by processing the raw LiDAR data in the analog domain, the proposed hybrid electro-optic computing platform minimizes the number of data converters in LiDAR systems.
光、探测和测距(LiDAR)已经成为具有准确和可靠感知要求的应用的强大工具,例如,需要远程和高空间分辨率以及实时性能相结合的自动驾驶。由于处理原始激光雷达数据是一个大维度的非结构化3D点云,由于处理点云所用算法的性质,处理原始激光雷达数据的计算成本很高。特别是,用于激光雷达数据处理的神经网络包括几个层,每个层都需要执行大尺寸矩阵的乘法。在这种情况下,图形处理单元(gpu)不能用作硬件加速的实时独立设备,因为它们依赖于中央处理单元(CPU)进行数据卸载和调度用于处理点云的算法的执行,因此执行时间很高。为了解决上述挑战,我们提出了一种用于激光雷达系统的模拟神经网络(ANN)和混合cmos -光子平台的高效协同设计。该架构利用了光计算的高带宽和低延迟,显著提高了计算效率。特别是,在我们提出的架构中,集成了光子广播和重量架构的CMOS控制芯片与LiDAR接口,以执行实时数据处理和高维矩阵乘法。此外,通过在模拟域中处理原始激光雷达数据,所提出的混合电光计算平台最大限度地减少了激光雷达系统中数据转换器的数量。
{"title":"Integrated photonic-electronic platform for real-time analog data processing in LiDARs","authors":"Mahsa Salmani, Sreenil Saha, A. Eshaghi","doi":"10.1117/12.2633086","DOIUrl":"https://doi.org/10.1117/12.2633086","url":null,"abstract":"Light, detection and ranging (LiDAR), has been emerging as a powerful tool for applications with accurate and reliable perception requirements, e.g., autonomous driving which needs a combination of long-range and high spatial resolution together with a real-time performance. Processing the raw LiDAR data, which is a large-dimensional unstructured 3D point cloud, is computationally costly due to the nature of the algorithms used for processing the point clouds. In particular, the neural networks employed for LiDAR data processing comprise several layers, for each of which multiplications of matrices with large sizes need to be performed. In this case, graphics processing units (GPUs) cannot be used as real-time standalone devices for hardware acceleration because they have high execution time due to their dependency on a central processing unit (CPU) for data offloading and scheduling the execution of the algorithms used to process point clouds. To address the aforementioned challenges, we propose an efficient co-design of an analog neural network (ANN) and a hybrid CMOS-Photonics platform for LiDAR systems. The proposed architecture exploits the high bandwidth and low latency of optical computation to significantly improve the computational efficiency. In particular, in our proposed architecture, a CMOS control chip integrated with a photonic broadcast-and-weight architecture is interfaced with LiDAR to perform real-time data processing and high-dimensional matrix multiplications. Moreover, by processing the raw LiDAR data in the analog domain, the proposed hybrid electro-optic computing platform minimizes the number of data converters in LiDAR systems.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76572122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wavelength selective silicon avalanche photodiodes with controlled wide spectral gain by integrating photon-trapping microstructures 波长选择性硅雪崩光电二极管与控制宽光谱增益集成光子捕获微结构
Amita Rawat, Ahasan Ahamed, Lisa N. Mcphillips, Busra Ergul-Yilmaz, Cesar Bartolo-Perez, Shih-Yuan Wang, M. Islam
Silicon avalanche photodiodes (Si-APD) are widely explored due to their high sensitivity, rapid response time, high quantum efficiency, intrinsic multiplication gain, and low signal-to-noise ratio. We present an experimental demonstration of a wavelength selective APD stack epitaxially grown in two different doping orders:–1) N-on-P and 2) P-on-N.We present a performance comparison between N-on-P and P-on-N based on the quantum external efficiency (EQE), Ion/Ioff ratio, and the reverse biased dark state leakage current. By reversing the doping from P-on-N to N-on-P, we show a 40% increase in the EQE. By introducing the photon-trapping hole array we show a 60% improvement in the EQE. We have utilized a low temperature (450oC) forming gas (5% H2 and 95% N2) annealing process to passivate the surface states and show a dark state leakage current improvement from sub- 10nA to sub-1nA current range. The proposed devices are complementary metal oxide semiconductor process compatible and can enable ‘detectors-on-chip’ technology for numerous applications such as internet-of-things, data communication, biomedical imaging, high-speed cloud computing, remote sensing, as well as single-photon detection.
硅雪崩光电二极管(Si-APD)以其高灵敏度、快速响应时间、高量子效率、固有倍增增益和低信噪比等优点得到了广泛的研究。我们提出了一个波长选择性APD堆栈外延生长在两种不同的掺杂顺序:- N-on-P和2)P-on-N的实验证明。我们基于量子外效率(EQE)、离子/ off比和反向偏置暗态漏电流对N-on-P和P-on-N进行了性能比较。通过从P-on-N到N-on-P的反向掺杂,我们发现EQE增加了40%。通过引入光子捕获空穴阵列,EQE性能提高了60%。我们利用低温(450℃)形成气体(5% H2和95% N2)退火工艺钝化表面状态,并显示出从低于10nA到低于1na电流范围内暗态泄漏电流的改善。所提出的器件是互补金属氧化物半导体工艺兼容的,可以使“片上探测器”技术用于物联网、数据通信、生物医学成像、高速云计算、遥感以及单光子检测等众多应用。
{"title":"Wavelength selective silicon avalanche photodiodes with controlled wide spectral gain by integrating photon-trapping microstructures","authors":"Amita Rawat, Ahasan Ahamed, Lisa N. Mcphillips, Busra Ergul-Yilmaz, Cesar Bartolo-Perez, Shih-Yuan Wang, M. Islam","doi":"10.1117/12.2637146","DOIUrl":"https://doi.org/10.1117/12.2637146","url":null,"abstract":"Silicon avalanche photodiodes (Si-APD) are widely explored due to their high sensitivity, rapid response time, high quantum efficiency, intrinsic multiplication gain, and low signal-to-noise ratio. We present an experimental demonstration of a wavelength selective APD stack epitaxially grown in two different doping orders:–1) N-on-P and 2) P-on-N.We present a performance comparison between N-on-P and P-on-N based on the quantum external efficiency (EQE), Ion/Ioff ratio, and the reverse biased dark state leakage current. By reversing the doping from P-on-N to N-on-P, we show a 40% increase in the EQE. By introducing the photon-trapping hole array we show a 60% improvement in the EQE. We have utilized a low temperature (450oC) forming gas (5% H2 and 95% N2) annealing process to passivate the surface states and show a dark state leakage current improvement from sub- 10nA to sub-1nA current range. The proposed devices are complementary metal oxide semiconductor process compatible and can enable ‘detectors-on-chip’ technology for numerous applications such as internet-of-things, data communication, biomedical imaging, high-speed cloud computing, remote sensing, as well as single-photon detection.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87583598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Monitoring glycation using the intrinsic fluorescence of biological fluorophores 利用生物荧光团的固有荧光监测糖基化
Rhona Muir, S. Forbes, D. Birch, O. Rolinski
The high blood glucose levels associated with diabetes affect various cells and proteins in the body. In response to high blood glucose collagen and keratin proteins experience glycation. This work aims to establish if the intrinsic fluorescence of collagen and keratin could be used to monitor the glycation of said compounds, and thus offer an alternative method to monitoring long term glycaemic control. We have studied the evolution of the intrinsic fluorescence of both compounds in response to glucose in vitro, using steady state and time-resolved fluorescence spectroscopy techniques. Changes in the intrinsic fluorescence of both collagen and keratin were observed. For collagen, contrary to the traditional fluorescence intensity decay measurement at arbitrarily selected excitation and detection wavelengths, we conducted systematic wavelength- and time-resolved measurements to achieve time-resolved emission spectra (TRES). These showed changes in the intrinsic fluorescence kinetics, caused by both collagen aggregation and glycation. In keratin, the addition of glucose caused an increase in the fluorescence intensity at the characteristic wavelength of 460 nm, due to faster formation of new cross-links. The results also suggest that glucose may cause the formation of two new fluorescent complexes with peak fluorescence at ~525 nm and ~575 nm. In conclusion, monitoring the intrinsic fluorescence of collagen or keratin could be used as a method to monitor long term glycaemic control in patients with diabetes.
与糖尿病相关的高血糖水平会影响体内的各种细胞和蛋白质。在高血糖反应中,胶原蛋白和角蛋白发生糖基化。这项工作旨在确定胶原蛋白和角蛋白的固有荧光是否可以用于监测所述化合物的糖基化,从而提供一种监测长期血糖控制的替代方法。我们利用稳态和时间分辨荧光光谱技术研究了这两种化合物在体外对葡萄糖的响应中固有荧光的演变。观察到胶原蛋白和角蛋白固有荧光的变化。对于胶原蛋白,与传统的任意选择激发和检测波长的荧光强度衰减测量不同,我们进行了系统的波长和时间分辨测量,以获得时间分辨发射光谱(TRES)。这些显示了内在荧光动力学的变化,由胶原聚集和糖基化引起。在角蛋白中,葡萄糖的加入使得在460 nm特征波长处的荧光强度增加,这是由于新的交联更快地形成。结果还表明,葡萄糖可能在~525 nm和~575 nm处形成两个新的荧光配合物。综上所述,监测胶原或角蛋白的固有荧光可作为监测糖尿病患者长期血糖控制的一种方法。
{"title":"Monitoring glycation using the intrinsic fluorescence of biological fluorophores","authors":"Rhona Muir, S. Forbes, D. Birch, O. Rolinski","doi":"10.1117/12.2631649","DOIUrl":"https://doi.org/10.1117/12.2631649","url":null,"abstract":"The high blood glucose levels associated with diabetes affect various cells and proteins in the body. In response to high blood glucose collagen and keratin proteins experience glycation. This work aims to establish if the intrinsic fluorescence of collagen and keratin could be used to monitor the glycation of said compounds, and thus offer an alternative method to monitoring long term glycaemic control. We have studied the evolution of the intrinsic fluorescence of both compounds in response to glucose in vitro, using steady state and time-resolved fluorescence spectroscopy techniques. Changes in the intrinsic fluorescence of both collagen and keratin were observed. For collagen, contrary to the traditional fluorescence intensity decay measurement at arbitrarily selected excitation and detection wavelengths, we conducted systematic wavelength- and time-resolved measurements to achieve time-resolved emission spectra (TRES). These showed changes in the intrinsic fluorescence kinetics, caused by both collagen aggregation and glycation. In keratin, the addition of glucose caused an increase in the fluorescence intensity at the characteristic wavelength of 460 nm, due to faster formation of new cross-links. The results also suggest that glucose may cause the formation of two new fluorescent complexes with peak fluorescence at ~525 nm and ~575 nm. In conclusion, monitoring the intrinsic fluorescence of collagen or keratin could be used as a method to monitor long term glycaemic control in patients with diabetes.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73420308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser-induced Si nanoparticles and the application of RGB resonance color-filters 激光诱导Si纳米粒子及其RGB共振滤色器的应用
Eui Sun Hwang, Min Jin Kang, B. Cheong
Optical resonances of nanoparticle have been studied for a long time in various optical devices. However, the difficulties in fabrication of uniform nanoparticles hinders the applications. Herein, we formed Si nanoparticles having a uniform size via laser irradiation on an amorphous-Si thin film and found the optical resonances of red, green, and blue (RGB) colors originated from the Si nanoparticles. Two-dimensional scanning of 355-nm wavelength of nanosecond laser with a Gaussian spot beam created Si nanoparticles of 100~200 nm at laser fluences of 150~200 mJ/cm2 . We demonstrated the color resonances could be tuned to red, green, and blue adjusting the laser fluence and scan pitch. The size and distribution are characterized by scanning electron microscopy (SEM), which revealed the Si nanoparticles are ellipsoidal shape, embedded in the residual Si layer. The optical properties are measured by dark field microscopy and fiber coupled spectroscopy. The RGB samples show peak wavelengths of 628 nm, 570 nm, and 495 nm, respectively, which are attributed to the dipole resonance as predicted by the Mie theory.
在各种光学器件中,人们对纳米粒子的光学共振进行了长期的研究。然而,均匀纳米颗粒的制备困难阻碍了其应用。在此,我们通过激光照射在非晶硅薄膜上形成了具有均匀尺寸的硅纳米颗粒,并发现了由硅纳米颗粒产生的红、绿、蓝(RGB)光共振。利用高斯光斑光束对波长为355 nm的纳秒激光进行二维扫描,在150~200 mJ/cm2的激光影响下,获得了100~200 nm的硅纳米颗粒。我们证明了颜色共振可以调整为红色,绿色和蓝色的激光能量和扫描间距。扫描电镜(SEM)表征了Si纳米颗粒的尺寸和分布,发现Si纳米颗粒呈椭球状,嵌入在残余Si层中。利用暗场显微镜和光纤耦合光谱对其光学特性进行了测量。RGB样品的峰值波长分别为628 nm、570 nm和495 nm,与Mie理论预测的偶极子共振有关。
{"title":"Laser-induced Si nanoparticles and the application of RGB resonance color-filters","authors":"Eui Sun Hwang, Min Jin Kang, B. Cheong","doi":"10.1117/12.2633033","DOIUrl":"https://doi.org/10.1117/12.2633033","url":null,"abstract":"Optical resonances of nanoparticle have been studied for a long time in various optical devices. However, the difficulties in fabrication of uniform nanoparticles hinders the applications. Herein, we formed Si nanoparticles having a uniform size via laser irradiation on an amorphous-Si thin film and found the optical resonances of red, green, and blue (RGB) colors originated from the Si nanoparticles. Two-dimensional scanning of 355-nm wavelength of nanosecond laser with a Gaussian spot beam created Si nanoparticles of 100~200 nm at laser fluences of 150~200 mJ/cm2 . We demonstrated the color resonances could be tuned to red, green, and blue adjusting the laser fluence and scan pitch. The size and distribution are characterized by scanning electron microscopy (SEM), which revealed the Si nanoparticles are ellipsoidal shape, embedded in the residual Si layer. The optical properties are measured by dark field microscopy and fiber coupled spectroscopy. The RGB samples show peak wavelengths of 628 nm, 570 nm, and 495 nm, respectively, which are attributed to the dipole resonance as predicted by the Mie theory.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79298087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of ultrasound image formation in the deep learning age
M. L. Lediju Bell
Historically, there are many options to improve image quality that are each derived from the same raw ultrasound sensor data. However, none of these historical options combine multiple contributions in a single image formation step. This invited contribution discusses novel alternatives to beamforming raw ultrasound sensor data to improve image quality, delivery speed, and feature detection after learning from the physics of sound wave propagation. Applications include cyst detection, coherence-based beamforming, and COVID-19 feature detection. A new resource for the entire community to standardize and accelerate research at the intersection of ultrasound beamforming and deep learning is summarized (https://cubdl.jhu.edu). The connection to optics with the integration of ultrasound hardware and software is also discussed from the perspective of photoacoustic source detection, reflection artifact removal, and resolution improvements. These innovations demonstrate outstanding potential to combine multiple outputs and benefits in a single signal processing step with the assistance of deep learning.
从历史上看,有许多选项可以提高图像质量,每个选项都来自相同的原始超声传感器数据。但是,这些历史选项都不能在单个图像形成步骤中合并多个贡献。这篇特邀文章讨论了在学习声波传播的物理原理后,波束成形原始超声传感器数据的新替代方案,以提高图像质量、传输速度和特征检测。应用包括囊肿检测、基于相干的波束形成和COVID-19特征检测。总结了整个社会规范和加速超声波束形成和深度学习交叉研究的新资源(https://cubdl.jhu.edu)。本文还从光声源检测、反射伪影去除、分辨率提高等方面讨论了超声软硬件集成与光学的联系。这些创新展示了在深度学习的帮助下,在单个信号处理步骤中结合多个输出和收益的巨大潜力。
{"title":"Applications of ultrasound image formation in the deep learning age","authors":"M. L. Lediju Bell","doi":"10.1117/12.2631614","DOIUrl":"https://doi.org/10.1117/12.2631614","url":null,"abstract":"Historically, there are many options to improve image quality that are each derived from the same raw ultrasound sensor data. However, none of these historical options combine multiple contributions in a single image formation step. This invited contribution discusses novel alternatives to beamforming raw ultrasound sensor data to improve image quality, delivery speed, and feature detection after learning from the physics of sound wave propagation. Applications include cyst detection, coherence-based beamforming, and COVID-19 feature detection. A new resource for the entire community to standardize and accelerate research at the intersection of ultrasound beamforming and deep learning is summarized (https://cubdl.jhu.edu). The connection to optics with the integration of ultrasound hardware and software is also discussed from the perspective of photoacoustic source detection, reflection artifact removal, and resolution improvements. These innovations demonstrate outstanding potential to combine multiple outputs and benefits in a single signal processing step with the assistance of deep learning.","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80222130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser interference and nanospheres UV lithography to produce micro and nanostructured TiO2 and TiN based sol-gel layers 激光干涉和纳米球UV光刻技术制备微纳米结构TiO2和TiN基溶胶-凝胶层
Y. Jourlin, N. Crespo-Monteiro, V. Vallejo Otero, M. Traynar, M. U. Usuga Higuita, E. Gamet
In this paper, a direct and cost-effective sol-gel method to produce stable titanium dioxide and titanium oxynitride photoresists is described. This approach is compatible with many photolithographic techniques. We show that laser interference lithography and nanosphere lithography can be used, respectively, to obtain homogeneous TiO2 diffraction gratings and periodic nanopillars over large areas. Further developments permit to transform TiO2 microstructured based sol-gel to TiN metallic microstructured layer, with good optical properties, by using an innovative rapid thermal nitridation process, which opens the way towards plasmonics and NIR filters based on periodic metallic microstructured layers. Further technological processes were conducted to produce micro and nanostructured TiO2 and TiN layers from a NanoImprint approach. This work demonstrates the versatility of this complete process of soft chemistry new process of patterning TiO2 and TiN thin films avoiding expensive processes (etching, lift-off…) while preserving their diffractive properties and a high thermal stability, up to 1000°C. It is thus compatible to various types of substrates (of different shape and size). These results open up the opportunity to develop a cost-effective and low time-consuming approach to address different fields of cutting-edge applications (metasurfaces, sensors, luxury and decorative industry…).
本文介绍了一种直接、经济的溶胶-凝胶法制备稳定的二氧化钛和氮化钛光刻胶的方法。这种方法与许多光刻技术兼容。我们证明了激光干涉光刻和纳米球光刻可以分别获得均匀的TiO2衍射光栅和大面积的周期性纳米柱。进一步的发展允许通过使用创新的快速热氮化工艺将TiO2微结构基溶胶凝胶转化为具有良好光学性能的TiN金属微结构层,这为基于周期性金属微结构层的等离子体和近红外滤波器开辟了道路。采用纳米压印方法进一步制备了微纳米结构的TiO2和TiN层。这项工作证明了这种完整的软化学过程的多功能性,该过程避免了昂贵的过程(蚀刻,剥离…),同时保持了它们的衍射特性和高达1000°C的高热稳定性。因此,它与各种类型的基材(不同形状和尺寸)兼容。这些结果为开发具有成本效益和低耗时的方法提供了机会,以解决不同领域的尖端应用(超表面,传感器,奢侈品和装饰行业……)。
{"title":"Laser interference and nanospheres UV lithography to produce micro and nanostructured TiO2 and TiN based sol-gel layers","authors":"Y. Jourlin, N. Crespo-Monteiro, V. Vallejo Otero, M. Traynar, M. U. Usuga Higuita, E. Gamet","doi":"10.1117/12.2635170","DOIUrl":"https://doi.org/10.1117/12.2635170","url":null,"abstract":"In this paper, a direct and cost-effective sol-gel method to produce stable titanium dioxide and titanium oxynitride photoresists is described. This approach is compatible with many photolithographic techniques. We show that laser interference lithography and nanosphere lithography can be used, respectively, to obtain homogeneous TiO2 diffraction gratings and periodic nanopillars over large areas. Further developments permit to transform TiO2 microstructured based sol-gel to TiN metallic microstructured layer, with good optical properties, by using an innovative rapid thermal nitridation process, which opens the way towards plasmonics and NIR filters based on periodic metallic microstructured layers. Further technological processes were conducted to produce micro and nanostructured TiO2 and TiN layers from a NanoImprint approach. This work demonstrates the versatility of this complete process of soft chemistry new process of patterning TiO2 and TiN thin films avoiding expensive processes (etching, lift-off…) while preserving their diffractive properties and a high thermal stability, up to 1000°C. It is thus compatible to various types of substrates (of different shape and size). These results open up the opportunity to develop a cost-effective and low time-consuming approach to address different fields of cutting-edge applications (metasurfaces, sensors, luxury and decorative industry…).","PeriodicalId":13820,"journal":{"name":"International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77560611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
International Conference on Nanoscience, Engineering and Technology (ICONSET 2011)
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1