International Journal for Vitamin and Nutrition Research最新文献

Background: The magnesium depletion score (MDS), a novel clinical score, incorporates alcohol consumption, kidney disease, use of diuretics and proton pump inhibitors (PPIs) to assess magnesium levels. However, the prognostic significance of the MDS individuals with nonalcoholic fatty liver disease (NAFLD) remains uncertain. This research aimed to explore the relationship between the MDS and mortality outcomes in NAFLD patients, including all-cause mortality, cancer mortality, and cardiovascular disease (CVD) mortality.

Method: Data acquired on 16,394 NAFLD patients from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018 were analyzed in this cohort study. Mortality outcomes were assessed using the linked National Death Index, which included all-cause mortality, cancer mortality, and CVD mortality. Cox proportional hazards models were used to determine the hazard ratios (HRs) for mortality outcomes related to the MDS. Subgroup analyses were also performed to explore the potential modifying influences of different demographic and clinical characteristics.

Result: An elevated MDS was associated with significantly higher risks of all-cause mortality (HR 1.22; 95% CI, 1.15-1.30), cancer mortality (HR 1.15; 95% CI, 1.03-1.28), and CVD mortality (HR 1.33; 95% CI, 1.18-1.51). While these associations remained consistent in many subgroups, factors such as gender, education level, and alcohol consumption influenced the link between the MDS and mortality.

Conclusion: The MDS is as an innovative and feasible prognostic indicator for mortality among NAFLD patients. Incorporating the MDS into clinical practice could improve risk stratification and inform targeted interventions aimed at diminishing the risk of mortality linked to magnesium deficiency within this group.

Background: Our study aimed to gain from a comprehensive understanding of organic food consumption in Switzerland.

Methods: Data from the Swiss National Nutrition Survey menuCH (2014-2015, n = 2057, 18 to 75 years old)and a cross-sectional, population-based survey were used. Dietary information was collected using two non-consecutive 24-hour dietary recalls (24HDRs). Organic foods were classified using information about food descriptors and labels. Participants were classified as organic food consumers if they had consumed organic foods in at least one 24HDR. Binomial logistic regression models were used to identify factors associated with organic food consumption.

Results: This study determined that 27.8% of the Swiss population consumed organic food. However, only 3.6% of all food consumed within this group of organic food consumers was organic. Food products of plant origin tended to be consumed more frequently as organic than were those of animal origin, except for eggs and dairy products. Organic food consumption was positively associated with female sex (odds ratio (OR) = 2.18, 95% confidence interval (CI) 1.69, 2.80), high educational degree (OR = 1.28, 95% CI 1.02, 1.61), and high alternate healthy eating index (OR = 5.45, 95% CI 3.70, 8.02), and negatively associated with young age (OR = 0.56, 95% CI 0.40, 0.78), French-speaking living area (OR = 0.73, 95% CI 0.56, 0.93), non-Swiss nationality (OR = 0.74, 95% CI 0.56, 0.98), large household size (OR = 0.59 95% CI 0.38, 0.89), and obesity (OR = 0.53, 95% CI 0.36, 0.77).

Conclusion: The present study provides a better understanding of the distribution of organic food consumption within the Swiss population and which subgroups consume particularly little organically produced food.

Clinical trial registration: Clinical Trial Registration: ISRCTN 16778734; https://www.isrctn.com/search?q=menuch.

Diet and nutrition have recently become a primary focus of public health worldwide. Food supplements (FSs), used to integrate common diets, are a highly marketed category of food products. This has positioned healthcare professionals (e.g., pharmacists) to have critical roles in their distribution and monitoring. Following a serious case of intoxication due to ingestion of potassium hydroxide (KOH) as a nutrient source in a FS, a technical analysis was carried out to assess the admissible levels of vitamins and minerals in such products. KOH, known for its high potential hydrogen (pH) and caustic properties, poses safety risks if not properly diluted. The EU Regulation 1169/2011 regulates the provision of food information to consumers and establishes minimum significant quantities for nutrients in all food products, including K, which must not exceed certain levels to ensure safety. The use of KOH as a unique K source has been shown to create high alkalinity, posing potential risks when dissolved in water for human consumption. Safer alternative forms of K are available for FS. This underscores the need for continuous regulatory oversight and involvement of public decision makers to ensure consumer safety, given the broad variability in FS formulations and their increasing market share.

Background: Nonalcoholic fatty liver disease (NAFLD) was clinically documented to be accompanied by iron homeostasis imbalances, however, the causal relationship between them remains unclear. Therefore, this study aimed to examine the relationship between iron homeostasis indicators (serum iron, ferritin, transferrin, total iron binding capacity (TIBC), and transferrin saturation (TSAT)) and NAFLD risk.

Methods: We applied two-sample Mendelian randomization (MR) to assess the effects of genetic liability to iron homeostasis indicators (N = 43,220-246,139) on NAFLD risk (N = 377,988) in individuals of European ancestry. Reverse direction MR, multivariable MR, and two-step MR were performed to estimate reverse association, causal effects independent of smoking or drinking, and the mediating effect of lipid metabolism, respectively. Smoking and drinking as confounders were considered confounders.

Results: Genetically predicted serum iron, ferritin, and TSAT were significantly associated with a higher risk of NAFLD (odds ratio (OR): 1.286, 95% confidence interval (CI): 1.075-1.539; p = 0.0059; OR: 1.260, 95% CI: 1.050-1.500, p = 0.0195; and OR: 1.223, 95% CI: 1.067-1.402; p = 0.0039, respectively). Reverse direction MR analysis suggested that genetic liability to NAFLD had no significant causal effect on iron homeostasis. Sex-specific MR exhibited a stronger effect size for the association of elevated ferritin with NAFLD risk in males (OR: 1.723, 95% CI: 1.338-2.219; p = 2.48 × 10^-5). Two-step MR revealed that elevated triglycerides (TGs) mediated approximately 3%-5% of the observed effect of serum iron and TSAT on NAFLD risk, while decreased low-density lipoprotein cholesterol (LDL-C) mediated 9%-10%.

Conclusion: Genetic liability to iron status imbalance may causally affect NAFLD. This evidence may support the clinical treatment of NAFLD in the target population.

Folate and folic acid (FA) are two forms of vitamin B9, a B-complex nutrient essential for the human body. Folate is the natural form of vitamin B9 and is found in foods such as citrus fruits, leafy green vegetables, and beans. In contrast, FA is the synthetic form and is commonly found in supplements and added to fortified foods. The metabolism of folate and FA plays a crucial role in DNA synthesis and methylation; therefore, understanding the mechanism through which a decrease in folate and FA consumption affects the development of breast cancer (BC) is important. DNA hypermethylation can inhibit the transcription of tumor suppressor genes, while DNA hypomethylation may have the same effect and activate oncogene transcription. However, some genetic variants exist, such as rs1801133 and rs1801131 in the MTHFR gene and rs1051266 in the RFC gene. The MTHFR gene encodes an enzyme that facilitates the utilization of folate to support essential bodily functions, while the RFC gene is responsible for transporting folate into cells and acts as an anion exchanger. Both genes intervene in the transport and absorption of FA and are related to an increased risk of cancer. Studies investigating the relationship between FA and BC often rely on in vitro and in vivo models; however, the findings may not fully translate to humans due to significant physiological and metabolic differences across species. This article explores how changes in FA metabolism due to malabsorption defects, a deficient diet or genetic variants may impact methylation processes and their relationship with BC.

Background: This study aimed to investigate how education centering around nutrition can influence diet quality and health-related behavior in the Spanish population.

Methods: A descriptive cross-sectional study was performed, and the validated NutSo-HH (Nutritional and Social Healthy Habits) questionnaire was administered. The overall sample was 1087 Spanish adults, 48.11% of whom had studied or were studying a degree in health sciences, compared to 51.89% who had no studies or were studying another subject. Differences between groups were assessed using statistical analyses.

Results: The results indicated that people with higher nutrition education exhibited an increased consumption of vegetables (3.64 vs. 3.50), cereals (3.09 vs. 2.70), legumes (2.19 vs. 2.10) and water (3.47 vs. 3.34) (all p < 0.001) and a lower consumption of red meat (1.60 vs. 1.73) (p < 0.001). No statistically significant differences were observed in the consumption of the remaining analyzed food products. People with health literacy reported better self-perceived health (3.94 vs. 3.76) (p < 0.001) and had a lower body mass index (BMI) (23.68 kg/m² vs. 24.75 kg/m²) (p < 0.001) than those without health literacy. No significant differences were observed in the time spent in sports practice and sedentary lifestyle or in variables related to eating disorders.

Conclusions: This study concluded that although health science education showed some benefits in eating habits and perceptions of well-being, did not significantly influence all aspects of nutritional habits and lifestyles. Further studies with a more holistic approach could provide a more complete picture of the influence of health education on overall well-being.

Background: Remnant cholesterol (RC) is a risk factor for the development of atherosclerosis. Vitamin E has antioxidant properties, making it a potentially effective management tool for preventing cardiovascular disease (CVD). However, the relationship between vitamin E intake and RC remains unclear.

Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) Survey 2007-2020. 11,585 participants (aged ≥20, 48% male) were included. Information on vitamin E intake (dietary vitamin E intake and total vitamin E intake) was collected. RC was defined as serum total cholesterol minus high-density lipoprotein and low-density lipoprotein cholesterol. Survey-weighted linear regression models and a restricted cubic spline (RCS) were used to test the relationship between vitamin E intake and RC. Subgroup analyses and interaction tests were also performed to verify the robustness of the results.

Results: After adjusting for all potential confounders (demographics, socioeconomic status, lifestyle, diet, and comorbidities), dietary vitamin E intake was negatively associated with RC (β = -0.21, 95% CI: (-0.29, -0.12), p < 0.0001), and this negative association was also present between total vitamin E intake and RC (β = -0.12, 95% CI: (-0.18, -0.06), p < 0.0001). The RCS analysis revealed a nonlinear negative association between vitamin E intake and RC. The negative correlation existed in different subgroups, with no interaction except for the "use of vitamin E supplements" subgroup.

Conclusion: Vitamin E intake showed a protective association with RC. The results suggest that increasing dietary vitamin E intake may help reduce RC levels and CVD risk.

Background: Vitamin D (VD) and gut microbiota (GM) are important variables in pediatric hematopoietic stem cell transplantation (HSCT) recipients with bloodstream infections (BSI). Both VD and GM play significant roles in immune regulation and in maintaining intestinal barrier function.

Methods: This prospective case-control study included 48 consecutive pediatric patients who underwent HSCT, as well as 20 healthy children from the community. Plasma samples were collected pre- and post-HSCT, together with post-HSCT fecal samples. Serum 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃) were measured using chemiluminescence and enzyme linked immunosorbent assay, respectively. GM was analyzed by 16S rDNA next generation sequencing.

Results: The incidence of BSI in pediatric HSCT recipients was 33.3% (16/48). No significant differences in serum 25(OH)D or 1,25(OH)₂D₃ levels were observed between the BSI and non-BSI groups either before or after transplantation, or with the healthy control group. The α-diversity of GM in BSI and non-BSI patients was significantly lower than in healthy subjects. Proteobacteria were significantly more abundant in BSI patients than in non-BSI patients (p = 0.0434) or healthy controls (p = 0.0193). Pediatric HSCT patients showed significantly higher levels of Staphylococcus (p < 0.001), Pseudomonas (p < 0.001), Enterococcus (p < 0.001), Clostridium innocuum (p = 0.0175) and Enterobacter (p = 0.0394) compared to the controls, whereas the levels of Firmicutes (p = 0.009), Actinobacteria (p < 0.001), Bifidobacterium (p < 0.001) and Faecalibacterium (p < 0.001) were significantly lower. β-diversity analysis revealed significant population differences between the three groups.

Conclusions: These results indicate there is no practical value in monitoring VD in HSCT patients. During HSCT and BSI, the GM experiences a loss of probiotics and an increase in potential pathogens.

Background: Dry Eye Disease (DED) significantly impacts global populations, causing discomfort and vision problems. This review explores the effects of lutein supplementation on DED symptoms and signs.

Methods: A systematic review was conducted following PRISMA guidelines, examining clinical trials from databases including PubMed, Web of Science, EMBASE, and the Cochrane Library. Six randomized controlled trials (RCTs) involving 584 subjects were included. Meta-analysis was not conducted due to heterogeneity in study designs, dosages, and outcome measures.

Results: Lutein dosages ranged from 3 mg/day to 20 mg/day, with treatment durations from 4 to 12 weeks. Improvements were observed in subjective symptoms, with significant reductions in Ocular Surface Disease Index (OSDI) scores in some studies. Objective measures also showed positive results: tear break-up time (TBUT) increased significantly in some trials. However, other studies reported no significant differences between treatment and control groups, reflecting heterogeneity in outcomes. Schirmer's test and corneal-conjunctival staining results varied, with some showing significant improvements and others not.

Conclusions: Lutein supplementation may benefit DED patients by improving symptoms and tear film stability. However, due to study heterogeneity, larger, well-designed RCTs are needed to establish standardized dosing and confirm these findings.

Background: This study aimed to elucidate correlations between obesity-related indicators and vitamin D (VD) status in a nationally representative sample of U.S. adults.

Methods: We analysed data from 9168 adults aged 20-59 years obtained from the 2011-2018 National Health and Nutrition Examination Survey. Serum 25 hydroxyvitamin D [25(OH)D] levels were measured and categorised into quartiles. Anthropometric measurements, including weight, waist circumference, and fat mass in various body regions quantified through dual-energy X-ray absorptiometry, were collected. Multiple imputation was employed to replace missing data. The importance of obesity-related indicators and serum 25(OH)D concentration was explored using multiple linear regression adjusted for demographics, lifestyle factors, dietary intake, and clinical biomarkers, and stepwise regression.

Results: Weight, waist circumference, and fat mass across all body regions were inversely associated with serum 25(OH)D levels (all p < 0.001). Notable differences were observed between men and women. Stepwise regression revealed a strong inverse correlation between visceral adipose tissue and serum 25(OH)D concentration in men [β 95% CI: -13.04 (-18.10, -7.99), p < 0.001], whereas in women, only weight was significantly correlated with serum 25(OH)D concentration [β 95% CI: -0.20 (-0.28, -0.12), p < 0.001]. Demographic attributes, seasonal sunlight exposure, dietary VD, calcium, phosphorus, and magnesium intake, and biomarkers including alkaline phosphatase and creatinine also emerged as significant predictors.

Conclusions: Besides conventional obesity measures, abdominal fat metrics exhibit robust associations with VD deficiency, especially in men. Public health initiatives and clinical management strategies for hypovitaminosis D in obese populations should consider nuanced aspects of adiposity distribution alongside other demographic, lifestyle, and dietary factors influencing VD.