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Ameliorative Potential of Vitamins on Haematological and Biochemical Profiles of Clarias gariepinus Fed Diets Contaminated with Fumonisin B1 维生素对饲粮中伏马菌素B1污染的加里宾Clarias血液学和生化特性的改善潜力
Pub Date : 2020-07-01 DOI: 10.22034/IJABBR.2020.40507
F. Gbore, A. M. Adewole, O. Oginni, O. Adu, T. Akinnubi, Kehinde I. Ologbonjaye, Adewumi Usaefat
Ameliorative potential of antioxidants –vitamins C and E on blood profile of Clarias gariepinus fed diets contaminated with varied levels of fumonisin B1 (FB1) was evaluated. Fusarium cultured maize containing FB1 were used to formulate diets containing approximately 2.5, 5.0, and 7.5 mg FB1/kg constituting diets 2, 3, and 4, respectively and other nine diets constituting Diets 5 - 13 with the same varied dietary FB1 concentrations but supplemented with 0.6g of vitamin C or E or vitamins C and E. These 12 diets and a control diet were used in 12-week feeding trial. Significant (P
研究了饲粮中添加不同水平伏马菌素B1 (FB1)后,抗氧化剂维生素C和E对加里平Clarias Clarias gariepinus血液特征的改善作用。采用含FB1的镰刀菌培养玉米配制饲料,FB1含量分别约为2.5、5.0和7.5 mg /kg,分别组成饲料2、3和4,其余9种饲料组成饲料5 ~ 13,饲料中FB1含量变化相同,但添加0.6g维生素C或E或维生素C和E。显著(P
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引用次数: 2
The Influence of Cognitive Learning Objective Domain on Clinical Competence Development Among Clinical Officer Interns in Meru and Tharaka-Nithi Counties 认知学习目标域对梅鲁县、塔拉卡-尼提县临床医师实习生临床能力发展的影响
Pub Date : 2020-07-01 DOI: 10.33945/SAMI/IJABBR.2020.4.8
Nyagah Josphat Mutungi, Eunice Muthoni, Lilian Muiruri
ABSTRACTGlobally, lives of seven billion people lie in the hands of 59 million health workers for care throughout their lifespan. This study purposed to establish the influence of cognitive learning objective domain on clinical competence development among clinical officer interns in Meru and Tharaka-Nithi Counties. The study used a descriptive longitudinal research design, which was necessitated by need for follow-up of respondents. The study had two groups as respondents made of clinical supervisors and clinical officer interns. The study used non-probability sampling method of purposeful for supervisors and probability sampling method of stratification for clinical officer interns. The study targeted 60 supervisors and selected purposefully a sample of 30, plus 150 Clinical officers interns and selected a sample of 109 using formulae by; Glen Israel, (2009). The study employed a semi - structured interview guide instrument on clinical supervisors and a structured questioner instrument on clinical officer interns. The findings of the study indicate that internship improved clinical competence development clinical officer Interns, as evidenced by lower scores before than after internship. Findings suggest that competencies of clinical officer interns are not yet well-developed as they start their internship, but improved at the end of internship. Significant difference was attained during their training on knowledge and skills but not much on attitudes. The study recommends that internship must be emphasized for improvement of cognitive and psychomotor with mentorship program for effective domain competence development among clinical officer interns in Kenya.
在全球范围内,70亿人的生命掌握在5900万卫生工作者的手中。本研究旨在探讨认知学习目标域对梅鲁县、塔拉卡-尼提县临床医师实习生临床能力发展的影响。本研究采用描述性纵向研究设计,需要对被调查者进行随访。该研究有两组作为调查对象,由临床主管和临床官实习生组成。本研究对督导人员采用目的性非概率抽样方法,对临床医师实习生采用分层概率抽样方法。本研究以60名主管为对象,有目的地选择了30名样本,加上150名临床官员实习生,选择了109名样本。格伦以色列,(2009)。本研究采用半结构式访谈指导工具对临床督导进行访谈,采用结构式提问工具对临床医师实习生进行访谈。本研究发现实习对临床医师临床能力发展有促进作用,表现为实习前得分低于实习后得分。研究结果表明,临床医师实习生的能力在开始实习时尚未得到很好的发展,但在实习结束时有所提高。在知识和技能方面的训练有显著差异,但在态度方面差异不大。本研究建议,在肯尼亚临床实习医师中,必须重视实习,以提高认知和精神运动能力,并通过指导计划有效地发展领域能力。
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引用次数: 0
Regenerative Medicine: Highlight on the Significance of Therapeutics with Novel Strategies 再生医学:强调新策略治疗的意义
Pub Date : 2020-07-01 DOI: 10.22034/IJABBR.2020.39984
M. Haddadi, M. Mousavi
Background: There is a worldwide effort to present novel approaches for the development of tolerance-induction treatments in regenerative medicine, after years of investigation in clinical transplantation. Particularly, novel approaches are based on controlling the immune response, including the application of biomaterials or imitation of antigen-specific peripheral tolerance in either solid-organ or allogeneic hematopoietic stem cell transplantation (HSCT).Methods: New biomaterials have been designed to alter the cell behavior in tissue-engineered creatures and also suppressing immune responses against cells and biomaterial scaffolds. Blunting immune responses has been evidenced to be a wise strategy in regenerative medicine. Incorporation of stem cell biologists, material scientists, and transplantation immunologists can lead to the most innovative solutions.Results: Replacing damaged tissues is the main goal of regenerative medicine. To reach this goal, it is vital to have a comprehensive understanding of the whole regeneration process; for example, the mechanisms of dedifferentiation of cells to progenitor cells or trans-differentiation into another cell types, and rescheduling of somatic cells to pluripotent cells.Conclusions: Exploring the regenerative processes under in vitro and in vivo situations sheds lights on the underlying molecular and cellular mechanisms and thereby helps to pave the way toward describing novel regenerative strategies to combat human diseases and finally to strengthen the regenerative medicine.
背景:经过多年的临床移植研究,全世界都在努力为再生医学耐受诱导治疗的发展提出新的方法。特别是,新的方法是基于控制免疫反应,包括在实体器官或异体造血干细胞移植(HSCT)中应用生物材料或模仿抗原特异性外周耐受性。方法:设计新的生物材料来改变组织工程生物的细胞行为,并抑制对细胞和生物材料支架的免疫反应。钝化免疫反应已被证明是一个明智的策略在再生医学。干细胞生物学家、材料科学家和移植免疫学家的结合可以带来最具创新性的解决方案。结果:损伤组织的替代是再生医学的主要目标。为了实现这一目标,对整个再生过程有一个全面的了解是至关重要的;例如,细胞向祖细胞的去分化或向其他细胞类型的反分化的机制,以及体细胞向多能细胞的重调度。结论:探索体外和体内情况下的再生过程,揭示了潜在的分子和细胞机制,从而有助于为描述新的再生策略铺平道路,以对抗人类疾病,最终加强再生医学。
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引用次数: 2
Histamine and Food Allergy 组胺和食物过敏
Pub Date : 2020-06-01 DOI: 10.33945/sami/ijabbr.2020.2.1
Negar Dinarvand, R. Azizi
Histamine is synthesized via histidine decarboxylase (HDC) in wide types of immune cells and is involved in abundant physiologic and pathologic processes. Histamine is a mediator released during inflammatory reactions, such as food allergy. Food allergy is immunological reactions to 'fight off' specific allergens within food in susceptible individuals. The aim of this study is investigation of the histamine hemostasis and food allergy to discover the relationship between them. Analysis of data from multiple electronic databases such as Scopus, PubMed, Google Scholar and Science Direct were performed. Various criteria were applied to select the articles for inclusion.Food allergy reaction is divided to 4 types of the immune response. These reactions with different mechanisms cause increased concentrations of histamine. Histamine does various action in different tissue. The correct and timely diagnosis of food allergy can lead to reduction of the chemicals release and inhibit of abnormal reaction of the body. According to some studies, Measurement of N-methylhistamine (NMH) as the major metabolite of histamine may help to diagnose patients with food-allergen induced clinical symptoms.
组胺是通过组氨酸脱羧酶(HDC)在多种类型的免疫细胞中合成的,并参与了丰富的生理和病理过程。组胺是炎症反应(如食物过敏)中释放的一种介质。食物过敏是易感人群“抵抗”食物中特定过敏原的免疫反应。本研究旨在探讨组胺性止血与食物过敏之间的关系。对Scopus、PubMed、Google Scholar、Science Direct等多个电子数据库的数据进行分析。采用了各种标准来选择纳入的文章。食物过敏反应分为4种类型的免疫反应。这些反应以不同的机制引起组胺浓度的增加。组胺在不同的组织中有不同的作用。正确及时的诊断食物过敏,可以减少体内化学物质的释放,抑制机体的异常反应。有研究表明,检测n -甲基组胺(NMH)作为组胺的主要代谢物可能有助于诊断食物过敏原引起的临床症状。
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引用次数: 2
The effect of halogen atoms at propanoate anion on thermo physical, vibrational spectroscopy, chemical reactivity, biological properties of morpholinium propionate Ionic Liquid 丙酸盐阴离子上卤素原子对丙酸morpholinium离子液体的热物理、振动光谱、化学反应性和生物学性质的影响
Pub Date : 2020-06-01 DOI: 10.33945/sami/ijabbr.2020.2.2
Sunanda Paul, A. Kumer, Md. Nuruzzaman Sarker, Mohammad Jahidul Islam
The morpholinium cation based ionic liquids are designed to evaluate the thermophysical, chemical reactivity, and biological activity. To estimate and design the bioactive ILs, propionate and trihalopropanoate were considered under theoretical study by Density Functional Theory (DFT). To make effect of halogens atom on anion, propionate, trifluro propionate, trichloro propionate, and tribromo propionate were taken for optimization. Some thermodynamic and thermophysical properties such as free energy, entropy, dipole moment, binding energy, nuclear energy, electronics energy, and heat of formation were calculated using DFT method and make a comparative effect for halogen atoms activity on anion. The free energy, binding energy, and heat of formation were the highest on morphonium trifluro propionate (IL02) and the second is on tribromo propionate (IL04). Quantitative Structure Activity Relationship (QSAR) like charge density, surface area grid, volume, LogP, polarizability, refractivity, and molecular mass were simulated and recorded, from which the biological activity was calculated. The chemical reactivity like HOMO, LUMO, HOMO-LUMO gap, ionization potential, hardness, softness electronegativity and electron affinity were calculated. The vibrational spectroscopy and UV spectroscopy data provide them the identification and characterization. To sum up, the thermophysical properties are highly affected by trifluro propionate anion then tribromo propionate, trichloro propionate, and propionate respectively. On the other hand, the chemical reactivity increases in order IL04, IL03, IL02, IL01 but biological activity is inversely changed.
本文设计了一种基于morpholinium阳离子的离子液体,用于评价其热物理、化学反应性和生物活性。利用密度泛函理论(DFT)对丙酸酯和三卤丙酸酯进行了理论研究。为考察卤素原子对阴离子的影响,以丙酸盐、三氟丙酸盐、三氯丙酸盐、三溴丙酸盐为优化剂。利用DFT方法计算了卤素原子的自由能、熵、偶极矩、结合能、核能、电子能、生成热等热力学和热物理性质,并比较了卤素原子对阴离子的活度影响。自由能、结合能和生成热在三氟丙酸铵(IL02)上最高,在三氟丙酸铵(IL04)上次之。模拟并记录电荷密度、表面积网格、体积、LogP、极化率、折射率、分子质量等定量构效关系(Quantitative Structure - Activity Relationship, QSAR),以此计算生物活性。计算了HOMO、LUMO、HOMO-LUMO间隙、电离势、硬度、柔软度、电负性和电子亲和性等化学反应性。振动光谱和紫外光谱数据为它们的鉴定和表征提供了依据。综上所述,三氟丙酸阴离子对热物性的影响较大,其次是三溴丙酸、三氯丙酸和丙酸。另一方面,化学活性依次为IL04、IL03、IL02、IL01,而生物活性则呈反比变化。
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引用次数: 3
Survey of Plants Used in Folk Medicine in Bali, Gashaka and Sarduana Local Government Areas Taraba State Nigeria for the Treatment of Cancers 尼日利亚塔拉巴州巴厘、Gashaka和Sarduana地方政府地区用于治疗癌症的民间医学植物调查
Pub Date : 2020-06-01 DOI: 10.22034/IJABBR.2020.38756
C. A. Ukwubile, Jude A. Odugu, Salihu Njidda, B. Umeokoli, Abdulqadir Bukar Bababe, M. Bingari, A. E. Angyu
Cancer disease has been on the increase recently in both developed and developing countries of the world resulting in 40 million deaths annually. Ethno-medicinal survey of indigenous herbal plants used in traditional medicine in the treatment of cancers was conducted in major communities in Bali, Gashaka and Sarduana Local Government Areas Taraba State Nigeria. Traditional medicine practitioners as well native herbalists, herbal plants and product marketers were orally interviewed by structured questionnaires. One hundred and six (106) species of plants from forty-nine (49) families were surveyed and documented in this study. Out of these, 70 % of the plants were neither screened for their anticancer activity nor documented in literatures while no any members of the Families Salvadoraceae, Simaroubaceae, and Elatinaceae have ever been reported for their anticancer activity. Members of the Family Fabaceae have the highest number of species distribution with 15%, followed by Family Asteraceae with 9% while Family Rubiaceae and Annonaceae have 6% and 5% distribution respectively. The leaves of the plants were the most used part in the treatment of cancers in all the communities, and preparation is usually by decoction. Sides effects of these plants were generally low on observation.The need for conservation of these plants is of utmost important because most these plants might go into extinct as a result of urbanization pressure and timber activities in most of these areas surveyed.
癌症疾病最近在世界发达国家和发展中国家都呈上升趋势,每年造成4 000万人死亡。在尼日利亚塔拉巴州巴里岛、加沙卡和萨杜阿纳地方政府地区的主要社区对传统医学中用于治疗癌症的土著草药植物进行了民族医学调查。通过结构化问卷对传统医学从业者、本土草药医师、草药植物和产品营销人员进行了口头访谈。本研究调查并记录了来自49科106种植物。其中,70%的植物既没有经过抗癌活性的筛选,也没有文献记载,而萨尔瓦多科、西马鲁巴科和白桦科的任何成员都没有被报道过抗癌活性。豆科的种类分布最多,占15%,其次是菊科,占9%,茜草科和番荔枝科分别占6%和5%。在所有社区中,植物的叶子是治疗癌症最常用的部分,并且通常通过煎煮制备。经观察,这些植物的副作用一般较低。保护这些植物的必要性是极其重要的,因为在大多数调查地区,由于城市化的压力和木材活动,大多数这些植物可能会灭绝。
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引用次数: 5
Finite Element Analysis of Small-scale Head of Combine Harvester for Harvesting Fine-Grain Products 细粒产品联合收割机小机头有限元分析
Pub Date : 2020-06-01 DOI: 10.22034/IJABBR.2020.38948
P. Bazyar, A. Jafari, R. Alimardani, V. Mohammadi, J. Grichar
Brasica napus L. is one of the most important crops in the world, but every year during mechanized harvesting with conventional combines large quantities of the seeds fall to the ground and thus result in a decrease in yield. Therefore, designing and manufacturing a head specific for harvesting this crop is a high priority. In this study, the head of a combine for harvesting fine-grained products were designed, manufactured and evaluated. Initially, different designs were modeled in Solidworks 2018 software and analyzed in Ansys workbench 2019 software. The best scheme was selected between different designs and a prototype was developed. The results of the analysis indicated that the fabricated apparatus has sufficient strength and stability. The results of field tests indicate that the generalization of the proposed scheme on the scale of a real combine harvester can help to decrease the grain loss for fine-grained products.
甘蓝型油菜是世界上最重要的作物之一,但每年在常规联合收割机机械化收获过程中,大量的甘蓝型油菜种子落在地上,导致产量下降。因此,设计和制造专门用于收获这种作物的头部是当务之急。在本研究中,设计、制造和评价了一种用于收获细粒产品的联合收割机的头部。首先,在Solidworks 2018软件中对不同的设计进行建模,并在Ansys workbench 2019软件中进行分析。在不同的设计方案中选出最佳方案,并研制出样机。分析结果表明,该装置具有足够的强度和稳定性。田间试验结果表明,将该方案推广到实际联合收割机上,有助于减少细粒产品的粒损。
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引用次数: 4
Electrochemical determination of Thyroxine Hormone in Human Blood through Magnetic Nanoparticles Composite Electrode 磁性纳米颗粒复合电极电化学测定人血液中甲状腺激素
Pub Date : 2020-06-01 DOI: 10.33945/sami/ijabbr.2020.4.4
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引用次数: 0
Introduction and discussion about three types of fine grain products and their harvesters 三种细粮产品及其收割机的介绍与探讨
Pub Date : 2020-06-01 DOI: 10.22034/IJABBR.2020.39702
P. Bazyar, A. Jafari, R. Alimardani, V. Mohammadi, J. Grichar
Fine grain products are harvested in two manual and mechanized forms. Nowadays, common combine harvesters are used, but fine grain products such as Rapeseed, Sesame and Sorghum cannot be harvested with conventional heads of combine harvesters due to the excessive grain loss in the head of the combine. Therefore, the necessity of design and fabricating machines and heads of combine harvesters became the center of attention to researchers because of the nutritional and medicinal benefits of fine-grain products. This research, encompasses an overview of the special headers and machines for harvesting three type of fine grain products with high loss and an evaluation of each of these harvesters.
细粮产品的收获分人工和机械化两种形式。目前使用的是普通的联合收割机,但由于联合收割机的头部损失过大,因此无法使用传统的联合收割机收获油菜籽、芝麻、高粱等细粮产品。因此,由于细粮产品的营养和药用价值,设计和制造机械和联合收割机头部的必要性成为研究人员关注的焦点。本研究概述了用于收获三种高损失细粮产品的专用集头和机器,并对每种收割机进行了评估。
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引用次数: 1
Introduction of Microbial as a Major Factor in the Human Body 微生物作为人体主要因素的介绍
Pub Date : 2020-06-01 DOI: 10.33945/sami/ijabbr.2020.2.3
S. M. Hosseini, S. Aiubi
The aim of this study is introduction on microbials as an effective agent in the human body. Microbial (symbiotic microorganisms) means the general and universal ecosystem of riches, all genes and masses of micronutrients, regardless of their genera and species, are referred to in a particular section. The symbiotic microbials have a symbiotic relationship with host creatures. This means that these microbes can also be partners, both pathogens. For example, all bacteria, fungi and other types of germs that live natively in the human skin are called microbiotics. The largest microbial of the human body is the microbioum of the digestive tract and, in particular, the large intestine. This term, although used more in medicine, is also valid in other branches of microbiology. They play an important role in health and disease. And trillions of bacteria, called microbials, that make up our bodies in our societies, involve the release of chemicals in the method of digestion, the delivery of medication, and the development and development of diseases such as heart disease, metabolic disorders (metabolism), or even cancer progression.
本研究的目的是介绍微生物在人体内的有效作用。微生物(共生微生物)是指一般和普遍的丰富生态系统,所有基因和大量微量营养素,不论其属和种,均在某一节中提及。共生微生物与宿主生物有共生关系。这意味着这些微生物也可以是伙伴,都是病原体。例如,所有的细菌、真菌和其他类型的细菌都生活在人体皮肤上,被称为微生物。人体最大的微生物是消化道的微生物,特别是大肠的微生物。这个术语虽然多用于医学,但也适用于微生物学的其他分支。它们在健康和疾病中起着重要作用。数以万亿计的细菌,被称为微生物,在我们的社会中构成了我们的身体,它们参与了消化过程中化学物质的释放,药物的输送,以及心脏病、代谢紊乱(代谢)甚至癌症进展等疾病的发生和发展。
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引用次数: 1
期刊
International journal of Advanced Biological and Biomedical Research
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