Pub Date : 2024-05-04DOI: 10.47070/ijapr.v12i4.3207
Shreya Verma, Amrish Verma, Jaspal Singh, Hasan Ali Ahmed, Dilip Kadam
Constipation, gas, and acidity are common gastrointestinal issues with a significant global prevalence. Traditional medicine systems like Ayurveda have long utilized medicinal plants to address these concerns. However, clinical validation of their efficacy in patients with constipation has been lacking. Objectives: This study aimed to assess the efficacy and safety of Petsaffa tablets, an Ayurvedic formulation containing various herbal ingredients, in relieving constipation, gas, and acidity. Methods: The study, conducted as a single-centric, open-label, non-randomized post-marketing surveillance study, involved 120 subjects with constipation. Subjects were evaluated using inclusion and exclusion criteria and provided Petsaffa tablets for a 14-day intervention. Various parameters, including bowel movement frequency, constipation scores, and subjective assessments, were measured. Vital signs, laboratory safety parameters, and adverse events were also monitored during the study period. Results: Petsaffa tablets significantly improved bowel movement frequency, constipation scores, and subjective symptoms related to constipation. Stool consistency and other associated symptoms such as acidity and gas were also reduced at the end of the study. None of the participants reported any adverse events, and safety parameters remained within normal limits during the study period. Conclusion: Petsaffa tablets offer a promising, safe, and effective alternative option for individuals with common gastrointestinal issues such as constipation, acidity, and gas.
{"title":"A Single Centric, Open-Label, Non-Randomized Post- Marketing Surveillance Study to Measure the Efficacy and Safety of Petsaffa Tablets in Subjects Suffering From Constipation, Gas and Acidity","authors":"Shreya Verma, Amrish Verma, Jaspal Singh, Hasan Ali Ahmed, Dilip Kadam","doi":"10.47070/ijapr.v12i4.3207","DOIUrl":"https://doi.org/10.47070/ijapr.v12i4.3207","url":null,"abstract":"Constipation, gas, and acidity are common gastrointestinal issues with a significant global prevalence. Traditional medicine systems like Ayurveda have long utilized medicinal plants to address these concerns. However, clinical validation of their efficacy in patients with constipation has been lacking. Objectives: This study aimed to assess the efficacy and safety of Petsaffa tablets, an Ayurvedic formulation containing various herbal ingredients, in relieving constipation, gas, and acidity. Methods: The study, conducted as a single-centric, open-label, non-randomized post-marketing surveillance study, involved 120 subjects with constipation. Subjects were evaluated using inclusion and exclusion criteria and provided Petsaffa tablets for a 14-day intervention. Various parameters, including bowel movement frequency, constipation scores, and subjective assessments, were measured. Vital signs, laboratory safety parameters, and adverse events were also monitored during the study period. Results: Petsaffa tablets significantly improved bowel movement frequency, constipation scores, and subjective symptoms related to constipation. Stool consistency and other associated symptoms such as acidity and gas were also reduced at the end of the study. None of the participants reported any adverse events, and safety parameters remained within normal limits during the study period. Conclusion: Petsaffa tablets offer a promising, safe, and effective alternative option for individuals with common gastrointestinal issues such as constipation, acidity, and gas.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"73 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.47070/ijapr.v12i4.3198
Saranya K, Ratheesh P, Surej Subash, Vinitha C, Nimisha Michael
Ayurveda pays utmost importance to Agni as it is the inherent factor behind every change that occurs in the body. The persistent Alpagni is said to be the causative factor for all the diseases. This is why Ama pachana and Agni deepana became the basic line of treatment in many diseases. Detailed and in-depth analysis of various classical references and articles published in reliable web resources has been done on the topic Deepana and Pachana and got some inferences. Pacana has role in conditions of Ama while Deepana in Agnimandya. But in our day to day practice when we have different Oushadha yoga, we can’t discriminate it in the formulations. The range of Deepana and Pachana may vary in each formulation. We may say at the Koshta level Deepana karma improves the Abhyavaharana shakti by stimulating the appetite and Pachana karma improves the Jaranashakthi by improving the digestion.
{"title":"Deepana and Pachana - An evaluative analysis","authors":"Saranya K, Ratheesh P, Surej Subash, Vinitha C, Nimisha Michael","doi":"10.47070/ijapr.v12i4.3198","DOIUrl":"https://doi.org/10.47070/ijapr.v12i4.3198","url":null,"abstract":"Ayurveda pays utmost importance to Agni as it is the inherent factor behind every change that occurs in the body. The persistent Alpagni is said to be the causative factor for all the diseases. This is why Ama pachana and Agni deepana became the basic line of treatment in many diseases. Detailed and in-depth analysis of various classical references and articles published in reliable web resources has been done on the topic Deepana and Pachana and got some inferences. Pacana has role in conditions of Ama while Deepana in Agnimandya. But in our day to day practice when we have different Oushadha yoga, we can’t discriminate it in the formulations. The range of Deepana and Pachana may vary in each formulation. We may say at the Koshta level Deepana karma improves the Abhyavaharana shakti by stimulating the appetite and Pachana karma improves the Jaranashakthi by improving the digestion.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"214 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.47070/ijapr.v12i4.3202
Manvitha Pagadala, Bikash Maharjan
Hridraya is an epitome of sustenance and co-ordination to maintain Ayu. It is considered as one of the three Marma sthana, and is the seat of Sarira, Buddhi, Indriya, Indriyartha, Saguna atma, Mana, etc so, any deviation in its functioning can be tremendously bereaving. Acharya Charaka, Sushruta, Vagbhata and Bhela have been unanimous regarding Hridaya being the seat of Manas and Buddhi. Hridroga is an ocean full of disease entities. In contemporary medical system, it is known as CVD i.e., Cardio-Vascular Disease. CVDs are the leading cause of death taking an estimated 17.9 million lives in 2019 accounting for whooping 32% of all the global deaths. Most cardiovascular diseases can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol. These risk factors can be effectively tackled by the judicious adherence to Dinacharya, Ratricharya, Ritucharya, Sadvritta niyamas, etc. Even in the state of disease, compliance with Sodhana procedures and Oushadhas can lead to alleviation of disease and qualitative improvement in the state of Ayu. This article gives 360° view of Shaman oushadhas related to Hridroga, which is explained by the Apta in various ancient texts.
{"title":"Management of Hridroga (CVD’S)","authors":"Manvitha Pagadala, Bikash Maharjan","doi":"10.47070/ijapr.v12i4.3202","DOIUrl":"https://doi.org/10.47070/ijapr.v12i4.3202","url":null,"abstract":"Hridraya is an epitome of sustenance and co-ordination to maintain Ayu. It is considered as one of the three Marma sthana, and is the seat of Sarira, Buddhi, Indriya, Indriyartha, Saguna atma, Mana, etc so, any deviation in its functioning can be tremendously bereaving. Acharya Charaka, Sushruta, Vagbhata and Bhela have been unanimous regarding Hridaya being the seat of Manas and Buddhi. Hridroga is an ocean full of disease entities. In contemporary medical system, it is known as CVD i.e., Cardio-Vascular Disease. CVDs are the leading cause of death taking an estimated 17.9 million lives in 2019 accounting for whooping 32% of all the global deaths. Most cardiovascular diseases can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol. These risk factors can be effectively tackled by the judicious adherence to Dinacharya, Ratricharya, Ritucharya, Sadvritta niyamas, etc. Even in the state of disease, compliance with Sodhana procedures and Oushadhas can lead to alleviation of disease and qualitative improvement in the state of Ayu. This article gives 360° view of Shaman oushadhas related to Hridroga, which is explained by the Apta in various ancient texts.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"62 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.47070/ijapr.v12i4.3183
Jesny V Jose, Shylamma T M, Aparna V K
Parkinson's Disease (PD) is a disease with insidious onset and slow progression. It is a neurologic condition that causes motor manifestations namely, bradykinesia, rigidity, resting tremor, postural instability and non-motor symptoms such as depression and dementia. The modern treatment provides some symptomatic relief but any proven means for slowing the progression have not been found yet. This case is of a 64-year-old male patient who presented with complaints of slowness in daily activities, difficulty in raising left upper arm along with heaviness, tremors in both hands, difficulty in speech and movement for 3 years. Complaints were increasing progressively hindering his routine activities. He underwent our IP management for 60 days with follow-up after every 20 days. In every follow-up, the patient reported significant relief in his symptoms and after two months, he was able to perform his routine activities without any help.
{"title":"Management of Rigidity Dominant Parkinson’s Disease Through Ayurvedic Protocol","authors":"Jesny V Jose, Shylamma T M, Aparna V K","doi":"10.47070/ijapr.v12i4.3183","DOIUrl":"https://doi.org/10.47070/ijapr.v12i4.3183","url":null,"abstract":"Parkinson's Disease (PD) is a disease with insidious onset and slow progression. It is a neurologic condition that causes motor manifestations namely, bradykinesia, rigidity, resting tremor, postural instability and non-motor symptoms such as depression and dementia. The modern treatment provides some symptomatic relief but any proven means for slowing the progression have not been found yet. This case is of a 64-year-old male patient who presented with complaints of slowness in daily activities, difficulty in raising left upper arm along with heaviness, tremors in both hands, difficulty in speech and movement for 3 years. Complaints were increasing progressively hindering his routine activities. He underwent our IP management for 60 days with follow-up after every 20 days. In every follow-up, the patient reported significant relief in his symptoms and after two months, he was able to perform his routine activities without any help.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"69 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.47070/ijapr.v12i4.3180
Chindu B S, Maya Balakrishnan, Giby Thomas
Vulvovaginal candidiasis is the infection of the vaginal mucosa and/or vulva caused by the Candida species, a gram-positive yeast-like fungus. It is the second most common vulvovaginal infection characterized by thick-curdy white-cottage-cheese type vaginal discharge and intense vulvovaginal pruritus. Symptomatically vulvovaginal candidiasis can be compared with Slaishmiki yonivyapat in Ayurveda, the line of management of which is the use of Ruksha and Ushna aushadha. Local application of gel has the advantages of easy administration, more bioavailability of drugs, and prolonged retention without much local irritation. The classical Guduchi-Triphala-Danti pariseka yoga, mentioned in Yonivyapat chikitsa has been modified into a gel form, facilitating self-administration by women. Methodology: Here is a case report of a 31-year-old multiparous woman who presented with complaints of curdy white vaginal discharge associated with itching over the vulvar region for the last 6 months. She was diagnosed with vulvovaginal candidiasis by vaginal swab culture. Intervention with Guduchi-Triphala-Danti gel was carried out for 14 days for 2 consecutive cycles excluding days of menstruation and followed up after the next 30 days without medication. Results: After completion of the treatment protocol there was substantial relief of symptoms like curdy white vaginal discharge and itching over the vulvar region, wet-mount microscopy was negative for pseudohyphae, and the vaginal swab culture showed no growth. Conclusion: Local application of Guduchi-Triphala-Danti gel was found to be effective in the management of vulvovaginal candidiasis.
{"title":"Ayurvedic Management of Vulvovaginal Candidiasis with Local Application of Guduchi-Triphala-Danti Gel","authors":"Chindu B S, Maya Balakrishnan, Giby Thomas","doi":"10.47070/ijapr.v12i4.3180","DOIUrl":"https://doi.org/10.47070/ijapr.v12i4.3180","url":null,"abstract":"Vulvovaginal candidiasis is the infection of the vaginal mucosa and/or vulva caused by the Candida species, a gram-positive yeast-like fungus. It is the second most common vulvovaginal infection characterized by thick-curdy white-cottage-cheese type vaginal discharge and intense vulvovaginal pruritus. Symptomatically vulvovaginal candidiasis can be compared with Slaishmiki yonivyapat in Ayurveda, the line of management of which is the use of Ruksha and Ushna aushadha. Local application of gel has the advantages of easy administration, more bioavailability of drugs, and prolonged retention without much local irritation. The classical Guduchi-Triphala-Danti pariseka yoga, mentioned in Yonivyapat chikitsa has been modified into a gel form, facilitating self-administration by women. Methodology: Here is a case report of a 31-year-old multiparous woman who presented with complaints of curdy white vaginal discharge associated with itching over the vulvar region for the last 6 months. She was diagnosed with vulvovaginal candidiasis by vaginal swab culture. Intervention with Guduchi-Triphala-Danti gel was carried out for 14 days for 2 consecutive cycles excluding days of menstruation and followed up after the next 30 days without medication. Results: After completion of the treatment protocol there was substantial relief of symptoms like curdy white vaginal discharge and itching over the vulvar region, wet-mount microscopy was negative for pseudohyphae, and the vaginal swab culture showed no growth. Conclusion: Local application of Guduchi-Triphala-Danti gel was found to be effective in the management of vulvovaginal candidiasis.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"10 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
‘Third-Eye Chakra’, also known as ‘Ajna Chakra’ in Sanskrit, is the sixth of the body's seven major Chakras. It is also known as the "perception center" and, said to be the seat of soul and the portal to higher awareness. It is essential for achieving greater awareness and serves as the focus of concentration during Asana or meditation practices. Ajna Chakra corresponds to the hypothalamus, pituitary gland, and pineal gland, as well as the eyes, ears, and nose in the physical body. Vedic manas yoga is a holistic approach to yoga that integrates concepts from the Vedas, ancient Indian literature, with practices that attempt to balance the mind, body, and spirit. This study was conducted to develop the inner consciousness and awake the dormant powers of individual participants using Vedic manas yoga. In this observational study, a total 30 physically and mentally healthy subject aged in between 5 to 15 years of both gender from Patanjali Gurukulam, Haridwar, were included. The Pre- and Post-treatment SF-36 scores were statistically evaluated using paired t-test. There was a significant difference (p<0.5) observed in mean scores of Pre-program and Post-program scores of SF-36 after three days programmed interventions against psycho-social, spiritual and emotional development of subjects. The paired t-test revealed a significant score having p<0.05 for pre-program and post-program questionnaire responses. The maximum improvement was recorded to be 22% with overall third-eye activation. Vedic manas yoga practice has shown significant improvement in SF-36 among subjects participating in this study and, further studies are recommended to awaken the inner consciousness and align the energies of body, mind and spirit.
{"title":"Elevating the Inner-Consciousness “Third-Eye” Through “Vedic Manas Yoga” Practice","authors":"Acharya Balkrishna, Prashant Katiyar, Muskan Chauhan, Jaya Upreti, Shubhangi Srivastava, Upasana Aggrawal, Shalini Singh, Vedpriya Arya","doi":"10.47070/ijapr.v12i4.3158","DOIUrl":"https://doi.org/10.47070/ijapr.v12i4.3158","url":null,"abstract":"‘Third-Eye Chakra’, also known as ‘Ajna Chakra’ in Sanskrit, is the sixth of the body's seven major Chakras. It is also known as the \"perception center\" and, said to be the seat of soul and the portal to higher awareness. It is essential for achieving greater awareness and serves as the focus of concentration during Asana or meditation practices. Ajna Chakra corresponds to the hypothalamus, pituitary gland, and pineal gland, as well as the eyes, ears, and nose in the physical body. Vedic manas yoga is a holistic approach to yoga that integrates concepts from the Vedas, ancient Indian literature, with practices that attempt to balance the mind, body, and spirit. This study was conducted to develop the inner consciousness and awake the dormant powers of individual participants using Vedic manas yoga. In this observational study, a total 30 physically and mentally healthy subject aged in between 5 to 15 years of both gender from Patanjali Gurukulam, Haridwar, were included. The Pre- and Post-treatment SF-36 scores were statistically evaluated using paired t-test. There was a significant difference (p<0.5) observed in mean scores of Pre-program and Post-program scores of SF-36 after three days programmed interventions against psycho-social, spiritual and emotional development of subjects. The paired t-test revealed a significant score having p<0.05 for pre-program and post-program questionnaire responses. The maximum improvement was recorded to be 22% with overall third-eye activation. Vedic manas yoga practice has shown significant improvement in SF-36 among subjects participating in this study and, further studies are recommended to awaken the inner consciousness and align the energies of body, mind and spirit.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"222 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3169
Aswathy M, Jithesh M
Considering the similarities noticed in the etiology and clinical features, COPD can be correlated to Tamaka shvasa among the Pranavaha srotodushti vikara, a condition where Pitta is involved along with Kapha and Vata. Rasayana is the main intervention in such a chronic disease and considering the Doshas and Rasayana, Virecana is the best preparatory Shodhana here to be administered for the patients. In Ayurveda, drug is denoted by the term ‘Bheshaja’ which is defined as the substance through which we can overcome the fear of disease. The ‘Upakarana’ which helps physician for maintaining the healthy condition or to alleviate disorders is said to be Bheshaja. Physician accomplishes the object ‘Vikara shamana’, by giving the appropriate Bheshaja according to different stages and conditions of the patient and disease. According to Ayurveda, action of a drug is based on its Guna, Virya, Vipaka and Prabhava. Fate of the drug always depends on Rasapancaka and it goes in line with modern pharmacodynamics. Besides that, the drug action also depends on the action of agni on that particular drug. In this article, a management protocol review on Chronic Obstructive Pulmonary Disease was carried out. The protocol selected and reviewed was Dipana with Panchakola curna in hot water, Snehapana with Kantakari ghrta, Abhyanga with Tila taila followed by Ushmasveda, Virecana with Vidangatanduladi curna and finally Pippali Vardhamana rasayana.
{"title":"Review on the Effect of An Ayurvedic Management Protocol in Chronic Obstructive Pulmonary Disease","authors":"Aswathy M, Jithesh M","doi":"10.47070/ijapr.v12i3.3169","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3169","url":null,"abstract":"Considering the similarities noticed in the etiology and clinical features, COPD can be correlated to Tamaka shvasa among the Pranavaha srotodushti vikara, a condition where Pitta is involved along with Kapha and Vata. Rasayana is the main intervention in such a chronic disease and considering the Doshas and Rasayana, Virecana is the best preparatory Shodhana here to be administered for the patients. In Ayurveda, drug is denoted by the term ‘Bheshaja’ which is defined as the substance through which we can overcome the fear of disease. The ‘Upakarana’ which helps physician for maintaining the healthy condition or to alleviate disorders is said to be Bheshaja. Physician accomplishes the object ‘Vikara shamana’, by giving the appropriate Bheshaja according to different stages and conditions of the patient and disease. According to Ayurveda, action of a drug is based on its Guna, Virya, Vipaka and Prabhava. Fate of the drug always depends on Rasapancaka and it goes in line with modern pharmacodynamics. Besides that, the drug action also depends on the action of agni on that particular drug. In this article, a management protocol review on Chronic Obstructive Pulmonary Disease was carried out. The protocol selected and reviewed was Dipana with Panchakola curna in hot water, Snehapana with Kantakari ghrta, Abhyanga with Tila taila followed by Ushmasveda, Virecana with Vidangatanduladi curna and finally Pippali Vardhamana rasayana.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"15 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3159
Swathy Sunil, Giby Thomas, Maya Balakrishnan
The most common benign uterine tumours affecting women in reproductive and perimenopausal stages are fibroids or leiomyomas. There is strong evidence that estrogen and progesterone promote the growth of fibroids, despite the fact that their exact aetiology is still unclear. This is because fibroids seldom arise before menarche and retreat after menopause. The most prevalent reason for hysterectomy is fibroids. Menorrhagia, polymenorrhoea, metrorrhagia, intermenstrual bleeding, infertility, repeated abortions, pain and pressure feelings, abdominal lumps, and vaginal discharge are a few of the symptoms they exhibit clinically. In Ayurveda there is no exact correlation for uterine fibroid. Fibroids can be considered as Mamsa Grandhis, one among the Grandhis described by Charaka and Vagbhata. They increase the surface area of the endometrial tissue in the uterus when present, causing excessive bleeding, pressure feelings, dysmenorrhea, and even infertility. Vata-Kapha predominant Tridoshas have a role in the aetiology of the Granthi Roga, necessitating the use of Vata-kaphahara medicines. As Granthi can also be caused by Mandagni, in Granthi chikitsa we can make use of Dravyas that are Deepana pachana. According to Acharya Susrutha, Sopha Chikitsa is included in the Apakwa Granthi chikitsa. In Mamsa granthi chikitsa, Shothagna, Lekhana, Chedhana, and Vatanulomana dravyas may be utilised. Asrigdara chikitsa and Raktapitta chiktsa can be used to treat fibroids when heavy, prolonged menstrual cycles are present. A 38 year old lady was presented with complaints of heavy, prolonged bleeding during menstruation along with lower abdomen pain. On USG she was diagnosed with uterine fibroids. Guggulu tikitakam kashayam was given for 3 months and after follow up symptoms were evaluated. She was relieved from prolonged heavy bleeding during menstruation and lower abdomen pain. From this case report, it is evident that Guggulu tiktakam kashayam is effective in uterine fibroids
{"title":"Effect of Guggulu Tiktakam Kashayam in Uterine Fibroid","authors":"Swathy Sunil, Giby Thomas, Maya Balakrishnan","doi":"10.47070/ijapr.v12i3.3159","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3159","url":null,"abstract":"The most common benign uterine tumours affecting women in reproductive and perimenopausal stages are fibroids or leiomyomas. There is strong evidence that estrogen and progesterone promote the growth of fibroids, despite the fact that their exact aetiology is still unclear. This is because fibroids seldom arise before menarche and retreat after menopause. The most prevalent reason for hysterectomy is fibroids. Menorrhagia, polymenorrhoea, metrorrhagia, intermenstrual bleeding, infertility, repeated abortions, pain and pressure feelings, abdominal lumps, and vaginal discharge are a few of the symptoms they exhibit clinically. In Ayurveda there is no exact correlation for uterine fibroid. Fibroids can be considered as Mamsa Grandhis, one among the Grandhis described by Charaka and Vagbhata. They increase the surface area of the endometrial tissue in the uterus when present, causing excessive bleeding, pressure feelings, dysmenorrhea, and even infertility. Vata-Kapha predominant Tridoshas have a role in the aetiology of the Granthi Roga, necessitating the use of Vata-kaphahara medicines. As Granthi can also be caused by Mandagni, in Granthi chikitsa we can make use of Dravyas that are Deepana pachana. According to Acharya Susrutha, Sopha Chikitsa is included in the Apakwa Granthi chikitsa. In Mamsa granthi chikitsa, Shothagna, Lekhana, Chedhana, and Vatanulomana dravyas may be utilised. Asrigdara chikitsa and Raktapitta chiktsa can be used to treat fibroids when heavy, prolonged menstrual cycles are present. A 38 year old lady was presented with complaints of heavy, prolonged bleeding during menstruation along with lower abdomen pain. On USG she was diagnosed with uterine fibroids. Guggulu tikitakam kashayam was given for 3 months and after follow up symptoms were evaluated. She was relieved from prolonged heavy bleeding during menstruation and lower abdomen pain. From this case report, it is evident that Guggulu tiktakam kashayam is effective in uterine fibroids","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"37 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140742842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3152
Biswajit Samanta, S. K. Gupta, Amal K. Maji
Background and Aim: Antioxidants derived from natural sources, particularly those rich in flavonoids and phenolic compounds, have attracted considerable interest for their potential health benefits in combating oxidative stress-related diseases. This study aimed to evaluate the antioxidant potential of the ethyl acetate (EtAc) fraction obtained from Cyperus pangorei rhizome, focusing on both in vitro and in vivo assessments. Methods: The EtAc fraction was subjected to RP-HPLC analysis to identify and quantify phenolic compounds and flavonoids. Acute toxicity testing was performed to assess the safety profile of the EtAc fraction. In vitro antioxidant activity was determined using DPPH and ABTS+ radical scavenging assays. In vivo evaluation of antioxidant activity was conducted in Triton X-100-induced oxidative stress model in mice, measuring malondialdehyde (MDA) content, glutathione (GSH) levels, and superoxide dismutase (SOD) activity in liver tissues. Results: RP-HPLC analysis confirmed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. The fraction exhibited significant dose-dependent antioxidant activity in both DPPH and ABTS+ assays, with IC50 values indicating potent scavenging effects. In the Triton X-100-induced stress model, administration of the EtAc fraction led to a reduction in MDA levels, restoration of GSH levels, and enhancement of SOD activity in mouse liver tissues. Conclusion: The findings suggest that the EtAc fraction from C. pangorei possesses promising antioxidant properties, as evidenced by its ability to mitigate oxidative stress-related damage both in vitro and in vivo.
{"title":"Evaluation of In Vitro and In Vivo Antioxidant Potential of the Ethyl Acetate Fraction of Cyperus Pangorei Rhizome","authors":"Biswajit Samanta, S. K. Gupta, Amal K. Maji","doi":"10.47070/ijapr.v12i3.3152","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3152","url":null,"abstract":"Background and Aim: Antioxidants derived from natural sources, particularly those rich in flavonoids and phenolic compounds, have attracted considerable interest for their potential health benefits in combating oxidative stress-related diseases. This study aimed to evaluate the antioxidant potential of the ethyl acetate (EtAc) fraction obtained from Cyperus pangorei rhizome, focusing on both in vitro and in vivo assessments. Methods: The EtAc fraction was subjected to RP-HPLC analysis to identify and quantify phenolic compounds and flavonoids. Acute toxicity testing was performed to assess the safety profile of the EtAc fraction. In vitro antioxidant activity was determined using DPPH and ABTS+ radical scavenging assays. In vivo evaluation of antioxidant activity was conducted in Triton X-100-induced oxidative stress model in mice, measuring malondialdehyde (MDA) content, glutathione (GSH) levels, and superoxide dismutase (SOD) activity in liver tissues. Results: RP-HPLC analysis confirmed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. The fraction exhibited significant dose-dependent antioxidant activity in both DPPH and ABTS+ assays, with IC50 values indicating potent scavenging effects. In the Triton X-100-induced stress model, administration of the EtAc fraction led to a reduction in MDA levels, restoration of GSH levels, and enhancement of SOD activity in mouse liver tissues. Conclusion: The findings suggest that the EtAc fraction from C. pangorei possesses promising antioxidant properties, as evidenced by its ability to mitigate oxidative stress-related damage both in vitro and in vivo.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3171
Sonal Singh Kushwaha, Priya Gupta, Suman Panwar
Mutrakrichra roga (urinary disorders), is a prevalent ailment described in Ayurveda with diverse aetiologies and manifestations. Managing Mutrakrichra (urinary disorders) involves using various herbal drugs with diuretic, lithotriptic, and soothing properties. This study aims to compile and compare the drugs used in treating Mutrakrichra roga (urinary disorders) from different classical Ayurvedic texts or Samhitas, including Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, and other manuscripts. A systematic review of these texts was conducted to identify the drugs recommended for managing Mutrakrichra roga (urinary disorders). The findings revealed a rich repository of medicinal plants and formulations used for their therapeutic effects on urinary disorders, including Gokshura (Tribulus terrestris), Punarnava (Boerrhavia diffusa), and many others. This compilation of drugs from different Samhitas provides valuable insights into the traditional knowledge and practices of Ayurveda in managing Mutrakrichra roga. It underscores the need for further research and clinical studies to validate the efficacy and safety of these herbal remedies in contemporary healthcare practices.
{"title":"Ayurvedic Pharmacology for Mutrakrichra","authors":"Sonal Singh Kushwaha, Priya Gupta, Suman Panwar","doi":"10.47070/ijapr.v12i3.3171","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3171","url":null,"abstract":"Mutrakrichra roga (urinary disorders), is a prevalent ailment described in Ayurveda with diverse aetiologies and manifestations. Managing Mutrakrichra (urinary disorders) involves using various herbal drugs with diuretic, lithotriptic, and soothing properties. This study aims to compile and compare the drugs used in treating Mutrakrichra roga (urinary disorders) from different classical Ayurvedic texts or Samhitas, including Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, and other manuscripts. A systematic review of these texts was conducted to identify the drugs recommended for managing Mutrakrichra roga (urinary disorders). The findings revealed a rich repository of medicinal plants and formulations used for their therapeutic effects on urinary disorders, including Gokshura (Tribulus terrestris), Punarnava (Boerrhavia diffusa), and many others. This compilation of drugs from different Samhitas provides valuable insights into the traditional knowledge and practices of Ayurveda in managing Mutrakrichra roga. It underscores the need for further research and clinical studies to validate the efficacy and safety of these herbal remedies in contemporary healthcare practices.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"25 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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