Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3162
Parinita Kaundal, Sanjeev kumar Ranote
Bhallataka, also known as the marking nut or dhobi nut, is a potent ingredient in Ayurvedic medicine. Despite its irritant nature, it's been used for centuries to treat a myriad of diseases. Its oil, extracted using the Patala Yantra, is a key formulation in Ayurvedic pharmaceutics. Ayurveda, the ancient Indian system of medicine, is gaining global recognition for its holistic and natural approach to health. A significant part of Ayurvedic treatments are plant-based, ranging from raw plant materials to refined extracts. One such plant is Semecarpus anacardium Linn, the botanical source of Bhallataka. The plant is being traditionally used by the ancient healers in clinical practice. Apart from the clinical uses the plant was also used for marking clothes, as hair dyes and in many non-therapeutic uses as well. Bhallataka is a plant which holds much significance in Siddha and Unani system of medicine. Various studies have been conducted to understand its physical and chemical nature of the plant, in order to understand its use in therapeutic purposes. Chemical and phytochemical analysis of Bhallataka nut reveals a treasure trove of bioactive compounds- biflavonoids, phenolic compounds, bhilawanols, minerals, vitamins, and amino acids. These compounds make Bhallataka effective against various diseases like arthritis, tumors, and infections. The oil of Bhallataka, extracted using the Patala Yantra method, is particularly noteworthy. This oil is an integral part of Ayurvedic pharmaceutics, and its application is referenced in various ancient texts.
{"title":"Extraction and Analytical Study of Semecarpus Anacardium L. Seed Oil","authors":"Parinita Kaundal, Sanjeev kumar Ranote","doi":"10.47070/ijapr.v12i3.3162","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3162","url":null,"abstract":"Bhallataka, also known as the marking nut or dhobi nut, is a potent ingredient in Ayurvedic medicine. Despite its irritant nature, it's been used for centuries to treat a myriad of diseases. Its oil, extracted using the Patala Yantra, is a key formulation in Ayurvedic pharmaceutics. Ayurveda, the ancient Indian system of medicine, is gaining global recognition for its holistic and natural approach to health. A significant part of Ayurvedic treatments are plant-based, ranging from raw plant materials to refined extracts. One such plant is Semecarpus anacardium Linn, the botanical source of Bhallataka. The plant is being traditionally used by the ancient healers in clinical practice. Apart from the clinical uses the plant was also used for marking clothes, as hair dyes and in many non-therapeutic uses as well. Bhallataka is a plant which holds much significance in Siddha and Unani system of medicine. Various studies have been conducted to understand its physical and chemical nature of the plant, in order to understand its use in therapeutic purposes. Chemical and phytochemical analysis of Bhallataka nut reveals a treasure trove of bioactive compounds- biflavonoids, phenolic compounds, bhilawanols, minerals, vitamins, and amino acids. These compounds make Bhallataka effective against various diseases like arthritis, tumors, and infections. The oil of Bhallataka, extracted using the Patala Yantra method, is particularly noteworthy. This oil is an integral part of Ayurvedic pharmaceutics, and its application is referenced in various ancient texts.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3175
K Ambika, Aswathy Dev S, Vishnu P
Pemphigus is an autoimmune blistering disease which can be fatal if left untreated. In case of secondarily infected skin lesions, life threatening sepsis may develop. There is no specific treatment protocol for the management of pemphigus. The present study is aimed to treat a 57-year-old male patient clinically diagnosed with pemphigus foliaceus admitted in Kayachikitsa department in Govt. Ayurveda College, Thiruvananthapuram. Treatment was aimed at controlling the progression of disease, preventing infection and inducing healing of the affected area. In Ayurveda symptoms are more similar to Kaphapitha kushta especially Visphota kushta. Langhana, Snehapana and repeated Sodhana were the treatment protocols adopted. Ayurvedic approach in this single case of pemphigus is beneficial in correcting the inherent Agnimandya at Koshta and Dhatu level and thus provides significant result. PDAI score was used for assessment. Before treatment PDAI was 96, reduced to 24 after Sodhana and after treatment it was 6. There was no recurrence of symptoms after 2 weeks.
{"title":"Pemphigus Foliaceous with special reference to Visphota Kushta","authors":"K Ambika, Aswathy Dev S, Vishnu P","doi":"10.47070/ijapr.v12i3.3175","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3175","url":null,"abstract":"Pemphigus is an autoimmune blistering disease which can be fatal if left untreated. In case of secondarily infected skin lesions, life threatening sepsis may develop. There is no specific treatment protocol for the management of pemphigus. The present study is aimed to treat a 57-year-old male patient clinically diagnosed with pemphigus foliaceus admitted in Kayachikitsa department in Govt. Ayurveda College, Thiruvananthapuram. Treatment was aimed at controlling the progression of disease, preventing infection and inducing healing of the affected area. In Ayurveda symptoms are more similar to Kaphapitha kushta especially Visphota kushta. Langhana, Snehapana and repeated Sodhana were the treatment protocols adopted. Ayurvedic approach in this single case of pemphigus is beneficial in correcting the inherent Agnimandya at Koshta and Dhatu level and thus provides significant result. PDAI score was used for assessment. Before treatment PDAI was 96, reduced to 24 after Sodhana and after treatment it was 6. There was no recurrence of symptoms after 2 weeks.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3089
Vijay Kimtata, Vishu Gupta, Lakhbir Singh, Hasan Ali Ahmed, Lokesh Holagundi
Objectives: This study aimed to evaluate the potential efficacy and safety of Dr. Ortho capsules in managing various musculoskeletal conditions, including knee pain, joint stiffness, arthritis, bulky shoulders, joint inflammation, acute sports injuries, strains, and sprains. Methods: The study was a single centric, open-label, non-randomized, post-marketing surveillance study involving 120 subjects. Subjects were selected based on inclusion and exclusion criteria. The study assessed changes in pain intensity and disability levels after the administration of Dr. Ortho capsules, employing the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI), respectively. Additionally, safety was evaluated through physical examinations, vital sign monitoring, and laboratory safety parameters. Results: The study revealed significant reductions in pain intensity and disability levels among the participants. Pain intensity, as measured by VAS, decreased significantly (p< 0.0001) from a mean score of 4.84 at baseline (day 1) to 0.38 at the end of the study (day 30). Disability levels, indicated by ODI, significantly improved (p<0.0001) from a mean score of 14.73% at baseline to 1.88% at the end of the study. There were no reported adverse events during the study, and all safety parameters remained within normal ranges. Conclusion: The findings of the study suggest that Dr. Ortho capsules may offer effective relief for individuals with musculoskeletal conditions, reducing pain intensity and improving functional abilities. The absence of adverse events and the maintenance of normal safety parameters indicate the safety of Dr. Ortho capsules for human consumption.
研究目的本研究旨在评估正骨医生胶囊治疗各种肌肉骨骼疾病的潜在疗效和安全性，包括膝关节疼痛、关节僵硬、关节炎、肩周炎、关节发炎、急性运动损伤、拉伤和扭伤。研究方法该研究是一项单一中心、开放标签、非随机、上市后监测研究，涉及 120 名受试者。受试者根据纳入和排除标准进行选择。研究分别采用视觉模拟量表（VAS）和Oswestry残疾指数（ODI）评估了服用正骨医生胶囊后疼痛强度和残疾程度的变化。此外，还通过体格检查、生命体征监测和实验室安全参数对安全性进行了评估。结果研究显示，参与者的疼痛强度和残疾程度明显减轻。用 VAS 测量的疼痛强度从基线（第 1 天）的平均分 4.84 显著降至研究结束时（第 30 天）的 0.38（p< 0.0001）。ODI显示的残疾程度从基线时的平均分14.73%大幅提高到研究结束时的1.88%（p<0.0001）。研究期间没有不良事件报告，所有安全参数均保持在正常范围内。结论研究结果表明，Dr. Ortho 胶囊可有效缓解肌肉骨骼疾病患者的疼痛，降低疼痛强度，提高功能能力。没有不良事件发生，各项安全参数保持正常，这表明 Dr. Ortho 胶囊可安全供人服用。
{"title":"Assessment of Efficacy and Safety of Dr.Ortho Capsules in Managing Musculoskeletal Disorders: A Phase IV Post-Marketing Surveillance Study","authors":"Vijay Kimtata, Vishu Gupta, Lakhbir Singh, Hasan Ali Ahmed, Lokesh Holagundi","doi":"10.47070/ijapr.v12i3.3089","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3089","url":null,"abstract":"Objectives: This study aimed to evaluate the potential efficacy and safety of Dr. Ortho capsules in managing various musculoskeletal conditions, including knee pain, joint stiffness, arthritis, bulky shoulders, joint inflammation, acute sports injuries, strains, and sprains. Methods: The study was a single centric, open-label, non-randomized, post-marketing surveillance study involving 120 subjects. Subjects were selected based on inclusion and exclusion criteria. The study assessed changes in pain intensity and disability levels after the administration of Dr. Ortho capsules, employing the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI), respectively. Additionally, safety was evaluated through physical examinations, vital sign monitoring, and laboratory safety parameters. Results: The study revealed significant reductions in pain intensity and disability levels among the participants. Pain intensity, as measured by VAS, decreased significantly (p< 0.0001) from a mean score of 4.84 at baseline (day 1) to 0.38 at the end of the study (day 30). Disability levels, indicated by ODI, significantly improved (p<0.0001) from a mean score of 14.73% at baseline to 1.88% at the end of the study. There were no reported adverse events during the study, and all safety parameters remained within normal ranges. Conclusion: The findings of the study suggest that Dr. Ortho capsules may offer effective relief for individuals with musculoskeletal conditions, reducing pain intensity and improving functional abilities. The absence of adverse events and the maintenance of normal safety parameters indicate the safety of Dr. Ortho capsules for human consumption.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"19 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3177
Lekshmi P S, Navaneeth Krishnan N, Marikutty T C
Diabetic peripheral neuropathy is the damage of the nerves due to the uncontrolled diabetes. It can affect any of the neurons can affect any of the neurons. Diabetic distal symmetric sensory and sensorimotor polyneuropathy is the most prevalent type of diabetic neuropathy. The symptoms appear as sensory loss, first in the toes and progressively moving up the legs, fingers, and arms over time. Tingling sensation, Burning sensation, Deep aching pain are other related symptoms. A patient age 54 years with diabetes for past 15 years, hypertension, dyslipidemia, complains of burning sensation of both feet (right>left), numbness, pricking pain, unsteadiness while walking, brownish red discolouration of both lower limbs. The symptoms were gradual in onset. Nerve Conduction Study showed axonal type of motor and sensory affecting peroneal nerve neuropathy. He admitted in Vaidyaratnam Ayurveda College Hospital, done Vibrotherm Neuropathy Analyzer and revealed small and large fibre neuropathy with severe loss of sensations. The main intention of the study is to improve the quality of life of the patient by reducing the symptoms that is disturbing his day today routine. Patient given with anti diabetic Ayurvedic formulations internally. Externally Rookshana, Vatahara, Brimhana treatments were done. After the treatment, Michigan neuropathy screening instrument, diabetic Neuropathy symptom score, Toronto clinical scoring system score were reduced. Neuropathy Analyzer showed mild to moderate loss of sensation. By adopting Prameha hara chikitsa coupled with Vata vyadhihara chikitsa, complications of diabetes can be managed. It is important to focus on diet and regimen since diabetes is a lifestyle disorder and, in ayurveda it is considered as an Anushangi Vyadhi.
{"title":"Ayurvedic Treatment Modalities of Diabetic Peripheral Neuropathy","authors":"Lekshmi P S, Navaneeth Krishnan N, Marikutty T C","doi":"10.47070/ijapr.v12i3.3177","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3177","url":null,"abstract":"Diabetic peripheral neuropathy is the damage of the nerves due to the uncontrolled diabetes. It can affect any of the neurons can affect any of the neurons. Diabetic distal symmetric sensory and sensorimotor polyneuropathy is the most prevalent type of diabetic neuropathy. The symptoms appear as sensory loss, first in the toes and progressively moving up the legs, fingers, and arms over time. Tingling sensation, Burning sensation, Deep aching pain are other related symptoms. A patient age 54 years with diabetes for past 15 years, hypertension, dyslipidemia, complains of burning sensation of both feet (right>left), numbness, pricking pain, unsteadiness while walking, brownish red discolouration of both lower limbs. The symptoms were gradual in onset. Nerve Conduction Study showed axonal type of motor and sensory affecting peroneal nerve neuropathy. He admitted in Vaidyaratnam Ayurveda College Hospital, done Vibrotherm Neuropathy Analyzer and revealed small and large fibre neuropathy with severe loss of sensations. The main intention of the study is to improve the quality of life of the patient by reducing the symptoms that is disturbing his day today routine. Patient given with anti diabetic Ayurvedic formulations internally. Externally Rookshana, Vatahara, Brimhana treatments were done. After the treatment, Michigan neuropathy screening instrument, diabetic Neuropathy symptom score, Toronto clinical scoring system score were reduced. Neuropathy Analyzer showed mild to moderate loss of sensation. By adopting Prameha hara chikitsa coupled with Vata vyadhihara chikitsa, complications of diabetes can be managed. It is important to focus on diet and regimen since diabetes is a lifestyle disorder and, in ayurveda it is considered as an Anushangi Vyadhi.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3176
Harshitha. M, Chaitra Shree. S, Prakruthi. G
Shalakya tantra, also known as Uttamanga Chikitsa, focuses on the vital sense organs situated above the Jatru-clavicle, addressing diseases of the head (Shiras), ear (Karna), eye (Netra), throat (Kanta), and nose (Nasa). The eye is considered as very important part of the body which performs the work of vision and due to its sensitive nature, it needs great care. Acharya Sushrutha outlines four treatment methods like Bheshaja, Shastra, Kshara and Agni karma as important treatment modalities. Anushastra karma are the para-surgical procedures, entail performing surgical interventions without the use of Shastras - sharp surgical instruments. Acharya Sushrutha has mentioned 14 types of Anushastras among which Jalaukavacharana, Agnikarma and Ksharakarma are given more importance and described in detail. Due to the pradhanyatwa of these three procedures in treatment they are also known as Trividha Anushastra karma. Along with Vata, Pitta and Kapha doshas, Rakta also plays a major role in causing different Netra rogas. So, it is advisable to go for safest Raktamokshana to do Dushita rakta dosha nirharana. In this article, an attempt is made to elaborate the complete knowledge of Anushastras used in different Netra rogas mentioned by our Acharyas. These procedures are simple, less time consuming, non-invasive, safe and cost-effective.
{"title":"Trividha Anushastra Karma in Netraroga","authors":"Harshitha. M, Chaitra Shree. S, Prakruthi. G","doi":"10.47070/ijapr.v12i3.3176","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3176","url":null,"abstract":"Shalakya tantra, also known as Uttamanga Chikitsa, focuses on the vital sense organs situated above the Jatru-clavicle, addressing diseases of the head (Shiras), ear (Karna), eye (Netra), throat (Kanta), and nose (Nasa). The eye is considered as very important part of the body which performs the work of vision and due to its sensitive nature, it needs great care. Acharya Sushrutha outlines four treatment methods like Bheshaja, Shastra, Kshara and Agni karma as important treatment modalities. Anushastra karma are the para-surgical procedures, entail performing surgical interventions without the use of Shastras - sharp surgical instruments. Acharya Sushrutha has mentioned 14 types of Anushastras among which Jalaukavacharana, Agnikarma and Ksharakarma are given more importance and described in detail. Due to the pradhanyatwa of these three procedures in treatment they are also known as Trividha Anushastra karma. Along with Vata, Pitta and Kapha doshas, Rakta also plays a major role in causing different Netra rogas. So, it is advisable to go for safest Raktamokshana to do Dushita rakta dosha nirharana. In this article, an attempt is made to elaborate the complete knowledge of Anushastras used in different Netra rogas mentioned by our Acharyas. These procedures are simple, less time consuming, non-invasive, safe and cost-effective.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3155
Biswajit Samanta, S. K. Gupta, Amal K. Maji
Background and aim: Inflammation is a pivotal process implicated in various physiological and pathological conditions, necessitating the exploration of alternative anti-inflammatory agents with minimal side effects. This study aimed to investigate the anti-inflammatory potential of the standardized ethyl acetate (EtAc) fraction derived from Cyperus pangorei rhizomes. Methods: The rhizomes of C. pangorei were collected, processed, and subjected to extraction and fractionation to obtain the EtAc fraction. RP-HPLC analysis was employed to standardized the EtAc fraction against standard quercetin, luteolin, and apigenin. In vitro studies utilized peritoneal macrophages isolated from male Swiss albino rats to assess NO production and cytokine levels (IL-1β, IL-6, TNF-α) upon treatment with the EtAc fraction. In vivo evaluation was conducted using a carrageenan-induced rat paw edema model. Results: RP-HPLC analysis revealed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. In vitro studies demonstrated dose-dependent inhibition of LPS-induced NO production and suppression of inflammatory cytokines (IL-1β, IL-6, TNF-α) by the EtAc fraction. Furthermore, in the carrageenan-induced rat paw edema model, the EtAc fraction exhibited dose-dependent inhibition of paw edema. Conclusion: The findings of this study highlight the significant anti-inflammatory potential of C. pangorei rhizome extracts, particularly the EtAc fraction. The identified compounds, quercetin, luteolin, and apigenin, contribute to its anti-inflammatory activity by modulating key inflammatory mediators. These results support the potential therapeutic use of C. pangorei in managing inflammation-related disorders. Further research is warranted to elucidate the underlying mechanisms and evaluate the long-term efficacy and safety of C. pangorei extracts as anti-inflammatory agents.
背景和目的：炎症是与各种生理和病理状况有关的关键过程，因此有必要探索副作用最小的替代抗炎药物。本研究旨在调查从香附根茎中提取的标准化乙酸乙酯（EtAc）馏分的抗炎潜力。研究方法收集、处理、萃取和分馏香附根茎，以获得乙酸乙酯馏分。采用 RP-HPLC 分析法将 EtAc 部分与标准槲皮素、木犀草素和芹菜素进行标准化。体外研究利用分离自瑞士白化雄性大鼠的腹腔巨噬细胞，评估使用 EtAc 产物处理后的 NO 生成和细胞因子水平（IL-1β、IL-6、TNF-α）。使用卡拉胶诱导的大鼠爪水肿模型进行了体内评估。结果显示RP-HPLC分析显示，EtAc组分中含有槲皮素、木犀草素和芹菜素。体外研究表明，EtAc组分对LPS诱导的NO生成和炎症细胞因子（IL-1β、IL-6、TNF-α）的抑制具有剂量依赖性。此外，在卡拉胶诱导的大鼠爪水肿模型中，EtAc组分对爪水肿的抑制作用呈剂量依赖性。结论本研究的结果凸显了 C. pangorei 根茎提取物，尤其是 EtAc 部分的显著抗炎潜力。已确定的化合物槲皮素、木犀草素和芹菜素通过调节关键的炎症介质，促进了其抗炎活性。这些结果支持了 C. pangorei 在控制炎症相关疾病方面的潜在治疗用途。还需要进一步的研究来阐明其潜在机制，并评估 C. pangorei 提取物作为抗炎药物的长期有效性和安全性。
{"title":"Exploring the Anti-Inflammatory Potential of Cyperus pangorei Rhizome Extracts An In Vitro and In Vivo Study","authors":"Biswajit Samanta, S. K. Gupta, Amal K. Maji","doi":"10.47070/ijapr.v12i3.3155","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3155","url":null,"abstract":"Background and aim: Inflammation is a pivotal process implicated in various physiological and pathological conditions, necessitating the exploration of alternative anti-inflammatory agents with minimal side effects. This study aimed to investigate the anti-inflammatory potential of the standardized ethyl acetate (EtAc) fraction derived from Cyperus pangorei rhizomes. Methods: The rhizomes of C. pangorei were collected, processed, and subjected to extraction and fractionation to obtain the EtAc fraction. RP-HPLC analysis was employed to standardized the EtAc fraction against standard quercetin, luteolin, and apigenin. In vitro studies utilized peritoneal macrophages isolated from male Swiss albino rats to assess NO production and cytokine levels (IL-1β, IL-6, TNF-α) upon treatment with the EtAc fraction. In vivo evaluation was conducted using a carrageenan-induced rat paw edema model. Results: RP-HPLC analysis revealed the presence of quercetin, luteolin, and apigenin in the EtAc fraction. In vitro studies demonstrated dose-dependent inhibition of LPS-induced NO production and suppression of inflammatory cytokines (IL-1β, IL-6, TNF-α) by the EtAc fraction. Furthermore, in the carrageenan-induced rat paw edema model, the EtAc fraction exhibited dose-dependent inhibition of paw edema. Conclusion: The findings of this study highlight the significant anti-inflammatory potential of C. pangorei rhizome extracts, particularly the EtAc fraction. The identified compounds, quercetin, luteolin, and apigenin, contribute to its anti-inflammatory activity by modulating key inflammatory mediators. These results support the potential therapeutic use of C. pangorei in managing inflammation-related disorders. Further research is warranted to elucidate the underlying mechanisms and evaluate the long-term efficacy and safety of C. pangorei extracts as anti-inflammatory agents.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"68 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140742598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3044
Pratibha Rana, Seema Shukla
According to WHO estimation the global occurrence of uterine prolapse is increasing and is assumed to be two to twenty percent. In Ayureda Doshas involved in Prasramsini Yonivyapa is Pitta Pradhan Vata Dosha. So, for the Samprapti Vighatana of Prasramsini Yonivyapada treatment should emphasize mainly on Pitta and Vata Shamana. Acharaya Sushruta has described Prasramsini Yonivyapada in Pittaja Yonivyapada which can be correlated with and first and second degree uterine prolapse. This condition is usually encountered in perimenopausal or postmenopausal period although young age group with distress during labor is not an exemption. A 42 years old female presented with first degree uterine prolapse was treated with Yoni Dhadhyakara Lepa (Madanphala, Madhuyasti, Karpura) followed by Yoniprakshalana with Triphala Kwatha. This treatment was continued for seven days twice daily for three consecutive months with positive outcome and good symptomatic relief in the patient.
{"title":"Role of Yoni Dhadhyakara Lepa in First Degree Uterine Prolapse","authors":"Pratibha Rana, Seema Shukla","doi":"10.47070/ijapr.v12i3.3044","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3044","url":null,"abstract":"According to WHO estimation the global occurrence of uterine prolapse is increasing and is assumed to be two to twenty percent. In Ayureda Doshas involved in Prasramsini Yonivyapa is Pitta Pradhan Vata Dosha. So, for the Samprapti Vighatana of Prasramsini Yonivyapada treatment should emphasize mainly on Pitta and Vata Shamana. Acharaya Sushruta has described Prasramsini Yonivyapada in Pittaja Yonivyapada which can be correlated with and first and second degree uterine prolapse. This condition is usually encountered in perimenopausal or postmenopausal period although young age group with distress during labor is not an exemption. A 42 years old female presented with first degree uterine prolapse was treated with Yoni Dhadhyakara Lepa (Madanphala, Madhuyasti, Karpura) followed by Yoniprakshalana with Triphala Kwatha. This treatment was continued for seven days twice daily for three consecutive months with positive outcome and good symptomatic relief in the patient.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3150
Parul Sharma, Ved Bhushan Sharma, K.K.Sharma
Sleep – this natural urge is so essential phenomenon of life that engages our one third of life-span, still indulging in being slept is mystery to everyone. At one side adequate sleep quality imparts fair concentration, emotional, cognitive motivational harmony inside body’s mind, soul and consciousness. Contrary to which inadequate sleep or poor sleep quality leads to tiredness, lack of focus, exhaustion, a low pain tolerance, anxiety, irritational thoughts, hallucinations, loss of appetite, constipation and many more. Sleep has a positive impact over digestion, metabolism, nourishment and health. It is irresistible, irreplaceable and unique boon for us, which is pillar of our life. The natural cycle of sleep and awakening is depending on Awastha of Sharir Dosha, Kaal Dosha, and few more factors as depicted in Ayurveda texts. So, the quality of sleep depends on these factors. If there is Kshaya of Kapha, or Vriddhi of Vata and Pitta, then the quality of sleep disturbs. In the realm of holistic well-being, Ayurveda, the ancient Indian system of medicine, offers profound insights into optimizing sleep quality. Through personalized approaches, Ayurvedic remedies like herbal formulations, lifestyle modifications, and relaxation techniques aim to rebalance Doshas and promote restful sleep. Integrating practices such as meditation, gentle yoga, and consistent sleep routines can pacify Vata and Pitta Dosha, calm the mind, and induce relaxation, fostering deeper and more rejuvenating sleep. Ayurveda's holistic perspective provides a natural and sustainable pathway to address poor sleep quality and promote overall well-being. The present paper is here to discuss in detail about Sukh Nidra.
{"title":"Ayurvedic Insights on Improving Poor Sleep Quality","authors":"Parul Sharma, Ved Bhushan Sharma, K.K.Sharma","doi":"10.47070/ijapr.v12i3.3150","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3150","url":null,"abstract":"Sleep – this natural urge is so essential phenomenon of life that engages our one third of life-span, still indulging in being slept is mystery to everyone. At one side adequate sleep quality imparts fair concentration, emotional, cognitive motivational harmony inside body’s mind, soul and consciousness. Contrary to which inadequate sleep or poor sleep quality leads to tiredness, lack of focus, exhaustion, a low pain tolerance, anxiety, irritational thoughts, hallucinations, loss of appetite, constipation and many more. Sleep has a positive impact over digestion, metabolism, nourishment and health. It is irresistible, irreplaceable and unique boon for us, which is pillar of our life. The natural cycle of sleep and awakening is depending on Awastha of Sharir Dosha, Kaal Dosha, and few more factors as depicted in Ayurveda texts. So, the quality of sleep depends on these factors. If there is Kshaya of Kapha, or Vriddhi of Vata and Pitta, then the quality of sleep disturbs. In the realm of holistic well-being, Ayurveda, the ancient Indian system of medicine, offers profound insights into optimizing sleep quality. Through personalized approaches, Ayurvedic remedies like herbal formulations, lifestyle modifications, and relaxation techniques aim to rebalance Doshas and promote restful sleep. Integrating practices such as meditation, gentle yoga, and consistent sleep routines can pacify Vata and Pitta Dosha, calm the mind, and induce relaxation, fostering deeper and more rejuvenating sleep. Ayurveda's holistic perspective provides a natural and sustainable pathway to address poor sleep quality and promote overall well-being. The present paper is here to discuss in detail about Sukh Nidra.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"11 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3123
Ashok Lamani, Ramadevi G
A family's health is guaranteed by a healthy woman. Ayurveda and contemporary medicine have both discussed the idea of a healthy yoni at various stages of a woman's life, from adolescence to menopause. These days, vaginal infections are a major concern for people of all ages and socioeconomic backgrounds. Because women have a special role of giving birth, gynecological illnesses have gained enormous relevance in the medical field. The majority of gynecological problems are included under the word "Yonivyapad," which is used in Ayurveda to refer to women's health care. Among 20 Yoni Vyapath’s Kaphaja yonivyapath is the one which is due to vitiation of Kapha, this vitiated Kapha reaches the Yoni Pradesha causes signs and symptoms like Kandu, Picchila Srava and Alpa Vedana as well as Sthanika and Sarvadaihika Kapha Prakopa Laxana. The treatment of Kaphaja Yonivyapath explained in classic as Kapha hara Dravyas and Shodhana Chikitsa mainly Vamana is indicated. This can be correlated with vulvovaginitis which is caused due to bacterial vaginosis, moniliasis and trichomans vaginalis. In this review an attempt has been made in this work to provide a conceptual analysis that covers nearly all of the Nidana, Samprapti and Chikitsa of Kaphaja Yoni Vyapad according to both Ayurveda and modern.
{"title":"Comprehensive Review of Kaphaja Yonivyapath: Etiology, Diagnosis and Management Strategies","authors":"Ashok Lamani, Ramadevi G","doi":"10.47070/ijapr.v12i3.3123","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3123","url":null,"abstract":"A family's health is guaranteed by a healthy woman. Ayurveda and contemporary medicine have both discussed the idea of a healthy yoni at various stages of a woman's life, from adolescence to menopause. These days, vaginal infections are a major concern for people of all ages and socioeconomic backgrounds. Because women have a special role of giving birth, gynecological illnesses have gained enormous relevance in the medical field. The majority of gynecological problems are included under the word \"Yonivyapad,\" which is used in Ayurveda to refer to women's health care. Among 20 Yoni Vyapath’s Kaphaja yonivyapath is the one which is due to vitiation of Kapha, this vitiated Kapha reaches the Yoni Pradesha causes signs and symptoms like Kandu, Picchila Srava and Alpa Vedana as well as Sthanika and Sarvadaihika Kapha Prakopa Laxana. The treatment of Kaphaja Yonivyapath explained in classic as Kapha hara Dravyas and Shodhana Chikitsa mainly Vamana is indicated. This can be correlated with vulvovaginitis which is caused due to bacterial vaginosis, moniliasis and trichomans vaginalis. In this review an attempt has been made in this work to provide a conceptual analysis that covers nearly all of the Nidana, Samprapti and Chikitsa of Kaphaja Yoni Vyapad according to both Ayurveda and modern.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"76 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.47070/ijapr.v12i3.3172
Vineetha Cherian, Ambili Krishna
Avascular necrosis (AVN) is defined as cellular death of bone components due to interruption of the blood supply. The bone structures then collapse, resulting in pain, loss of joint function and long-term joint damage. Treatment goals for AVN are to improve the joint, stop the bone damage, and ease pain. In modern science treatment includes NSAIDS, core decompression, bone grafting and total joint arthroplasty which have their own complications, high cost and prognosis is also very poor. In Ayurveda it can be correlated to the Asthi-Majja gatha vata. In this Raktavaha Srotorodha also occur which results in Asthi Dhatu Kshaya. Aim of study is to introduce an alternative therapeutic modality through Ayurveda which help to reduce pain, improve quality of life and prevent further damage of bone which is cost effective as well. The present case report is a single case study of a 32year old female patient who was diagnosed with Stage Ⅱ Avascular Necrosis of bilateral femoral head done at Government Ayurveda College Panchakarma Hospital, Poojappura, Thiruvananthapuram. She was treated with selected Panchakarma treatments and specific Samana oushadhis. There was significant improvement in the symptoms which was assessed using relevant tools like VAS score for pain, goniometer for range of movement and Oxford Hip score for assessment of function and pain in hip. The present case study documents that Panchakarma procedures and Samana oushadhis can be effective in AVN and improve the quality of life of patient.
血管性坏死（AVN）是指由于血液供应中断导致骨成分的细胞死亡。骨结构随之塌陷，导致疼痛、关节功能丧失和长期关节损伤。AVN 的治疗目标是改善关节、阻止骨损伤和缓解疼痛。现代科学的治疗方法包括非甾体抗炎药、核心减压、骨移植和全关节成形术，这些方法都有各自的并发症，费用高昂，预后也很差。在阿育吠陀学中，它可以与 Asthi-Majja gatha vata 相关联。在这种情况下，Raktavaha Srotorodha 也会导致 Asthi Dhatu Kshaya。本研究的目的是通过阿育吠陀引入一种替代治疗方法，有助于减轻疼痛、提高生活质量并防止骨骼进一步受损，同时还具有成本效益。本病例报告是对一名 32 岁女性患者的单个病例研究，她在 Thiruvananthapuram 的 Poojappura 政府阿育吠陀学院 Panchakarma 医院被诊断为双侧股骨头血管性坏死Ⅱ期。她接受了选定的潘查卡玛疗法和特定的 Samana oushadhis 治疗。通过使用相关工具，如疼痛 VAS 评分、活动范围量角器和牛津髋关节评分来评估髋关节的功能和疼痛，她的症状得到了明显改善。本病例研究表明，Panchakarma 程序和 Samana oushadhis 可以有效治疗 AVN 并改善患者的生活质量。
{"title":"Ayurveda in the Management of Avascular Necrosis of Femoral Head - A Case Report","authors":"Vineetha Cherian, Ambili Krishna","doi":"10.47070/ijapr.v12i3.3172","DOIUrl":"https://doi.org/10.47070/ijapr.v12i3.3172","url":null,"abstract":"Avascular necrosis (AVN) is defined as cellular death of bone components due to interruption of the blood supply. The bone structures then collapse, resulting in pain, loss of joint function and long-term joint damage. Treatment goals for AVN are to improve the joint, stop the bone damage, and ease pain. In modern science treatment includes NSAIDS, core decompression, bone grafting and total joint arthroplasty which have their own complications, high cost and prognosis is also very poor. In Ayurveda it can be correlated to the Asthi-Majja gatha vata. In this Raktavaha Srotorodha also occur which results in Asthi Dhatu Kshaya. Aim of study is to introduce an alternative therapeutic modality through Ayurveda which help to reduce pain, improve quality of life and prevent further damage of bone which is cost effective as well. The present case report is a single case study of a 32year old female patient who was diagnosed with Stage Ⅱ Avascular Necrosis of bilateral femoral head done at Government Ayurveda College Panchakarma Hospital, Poojappura, Thiruvananthapuram. She was treated with selected Panchakarma treatments and specific Samana oushadhis. There was significant improvement in the symptoms which was assessed using relevant tools like VAS score for pain, goniometer for range of movement and Oxford Hip score for assessment of function and pain in hip. The present case study documents that Panchakarma procedures and Samana oushadhis can be effective in AVN and improve the quality of life of patient.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"30 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：