Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3051
Riddhi J Ganatra, Tukaram Sambhaji Dudhamal
Burn is one of the common conditions affected by individuals in day-to-day activity which needs extra attention to prevent ugly scars and many more complications. Ayurveda has a wide range of herbal formulations to manage such types of burn wounds. Among them, one is Madhuchistadi Ghrita which has burn wound healing properties by its Vrana Ropana drugs. A 45-year-old male patient suffered second-degree scald burn along with blisters and burning over the right hand for four days. The patient was successfully treated with a local application of Madhuchistadi Ghrita twice daily for 15 days. After seven days of treatment, the wound was 70% covered with epithelialization and at the end of 15 days, the wound was completely healed. During the follow-up period of 1 month, the skin was completely remodeled with the presence of skin appendages. This is a single case report with a positive outcome on the treatment of second-degree scald burns with the application of Madhuchistadi Ghrita.
{"title":"Treatment of Second-Degree Scald Burn with the Application of Madhuchistadi Ghrita","authors":"Riddhi J Ganatra, Tukaram Sambhaji Dudhamal","doi":"10.47070/ijapr.v12i1.3051","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3051","url":null,"abstract":"Burn is one of the common conditions affected by individuals in day-to-day activity which needs extra attention to prevent ugly scars and many more complications. Ayurveda has a wide range of herbal formulations to manage such types of burn wounds. Among them, one is Madhuchistadi Ghrita which has burn wound healing properties by its Vrana Ropana drugs. A 45-year-old male patient suffered second-degree scald burn along with blisters and burning over the right hand for four days. The patient was successfully treated with a local application of Madhuchistadi Ghrita twice daily for 15 days. After seven days of treatment, the wound was 70% covered with epithelialization and at the end of 15 days, the wound was completely healed. During the follow-up period of 1 month, the skin was completely remodeled with the presence of skin appendages. This is a single case report with a positive outcome on the treatment of second-degree scald burns with the application of Madhuchistadi Ghrita.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"2017 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spinal pathologies like cervical spondylosis and lumbar spondylosis have become very much prevalent due to lifestyle and environmental factors. Neck pain and low back pain is the leading cause of years lived with disabilities. Ayurveda always insisted on intervening at the early stage of every disease so that the progress of pathology can be prevented. To counteract these conditions, Ayurveda has put forth six-fold treatment methodologies called Shadupakrama. Rukshana is one among them which can be used as both Bahiparimarjana and Antahparimarjana chikitsa. With Rukshana therapy, the body’s oily, sticky, fatty constituents are dried up and reduced. In this case series, three cases related to spinal pathology, especially cervical and lumbar spondylosis were successfully treated by incorporating the principle of Rukshana. Initially, the condition was visualized as Kaphavruta Vata/Vataanubandha Kapha. Hence the first line of treatment should be Kaphavatahara. Apart from these there is the involvement of Ama in the Samprapthi and considering all these factors internally Rukshana was attained via oral medications and externally by Rukshana upakrama. After the Rukshana therapy patient shows marked improvement, assessments were recorded by comparing the grade of pain, joint tenderness, and range of motion before and after treatment. Notable changes are evidence that the Ayurvedic way of approach to treating spinal disorders is effective and successful. After Rukshana karma, Snigdha bahya karma was adopted along with some internal medications.
{"title":"A Case Series on Importance of Rukshana Therapy in Spinal Pathology","authors":"Nutan Mahato, Sudarsana Kaveri R.N, Shylamma T.M, Bindu P.R","doi":"10.47070/ijapr.v12i1.3068","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3068","url":null,"abstract":"Spinal pathologies like cervical spondylosis and lumbar spondylosis have become very much prevalent due to lifestyle and environmental factors. Neck pain and low back pain is the leading cause of years lived with disabilities. Ayurveda always insisted on intervening at the early stage of every disease so that the progress of pathology can be prevented. To counteract these conditions, Ayurveda has put forth six-fold treatment methodologies called Shadupakrama. Rukshana is one among them which can be used as both Bahiparimarjana and Antahparimarjana chikitsa. With Rukshana therapy, the body’s oily, sticky, fatty constituents are dried up and reduced. In this case series, three cases related to spinal pathology, especially cervical and lumbar spondylosis were successfully treated by incorporating the principle of Rukshana. Initially, the condition was visualized as Kaphavruta Vata/Vataanubandha Kapha. Hence the first line of treatment should be Kaphavatahara. Apart from these there is the involvement of Ama in the Samprapthi and considering all these factors internally Rukshana was attained via oral medications and externally by Rukshana upakrama. After the Rukshana therapy patient shows marked improvement, assessments were recorded by comparing the grade of pain, joint tenderness, and range of motion before and after treatment. Notable changes are evidence that the Ayurvedic way of approach to treating spinal disorders is effective and successful. After Rukshana karma, Snigdha bahya karma was adopted along with some internal medications.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"1986 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3087
Sruthi S S, S Anand
The utilization of various contemporary analytical methods has become indispensable when it comes to assessing polyherbal Ayurvedic formulations, aiming to ensure their quality, safety, and effectiveness. Quality control of herbal medicines involve analytical evaluation using instrumental techniques such as TLC, HPTLC, HPLC, GC-MS, LC-MS and spectrophotometer etc. Among them Liquid Chromatography with tandem Mass Spectrometry (LC-MS/MS) is a powerful hyphenated analytical technique that combines the separating power of liquid chromatography with the mass analysis capabilities of mass spectrometry. Generally, its application is oriented towards the specific detection and potential identification of chemicals in a complex mixture. Polyphenolic compounds are usually referred to as a diverse group of naturally occurring compounds containing multiple phenolic functionalities. The anti-inflammatory, anti-aging, antiproliferative, and antioxidant like biological properties of phenolic compounds have been described in several studies. This research study was taken to analyse polyphenolic compounds in Guduchyadi kashaya by LC-MS/MS. Phenolic compounds are abundant in the ingredients of Guduchyadi kashaya, as evidenced by previous studies. So, to determine the polyphenolic contents of Guduchyadi kashaya, this study was conducted. The quantification of the polyphenols was carried out on Shimadzu Shim Pack GISS C18 column with .1%formic acid as mobile phase. A total of 28 polyphenolic compounds were analysed, and 24 of these compounds were found to be present in Guduchyadi kashaya. The results showed that the phenolic compounds present in the ingredients were also present in the formulation in high abundance.
{"title":"Determination of Polyphenolic Compounds Present in Guduchyadi Kashaya Using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)","authors":"Sruthi S S, S Anand","doi":"10.47070/ijapr.v12i1.3087","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3087","url":null,"abstract":"The utilization of various contemporary analytical methods has become indispensable when it comes to assessing polyherbal Ayurvedic formulations, aiming to ensure their quality, safety, and effectiveness. Quality control of herbal medicines involve analytical evaluation using instrumental techniques such as TLC, HPTLC, HPLC, GC-MS, LC-MS and spectrophotometer etc. Among them Liquid Chromatography with tandem Mass Spectrometry (LC-MS/MS) is a powerful hyphenated analytical technique that combines the separating power of liquid chromatography with the mass analysis capabilities of mass spectrometry. Generally, its application is oriented towards the specific detection and potential identification of chemicals in a complex mixture. Polyphenolic compounds are usually referred to as a diverse group of naturally occurring compounds containing multiple phenolic functionalities. The anti-inflammatory, anti-aging, antiproliferative, and antioxidant like biological properties of phenolic compounds have been described in several studies. This research study was taken to analyse polyphenolic compounds in Guduchyadi kashaya by LC-MS/MS. Phenolic compounds are abundant in the ingredients of Guduchyadi kashaya, as evidenced by previous studies. So, to determine the polyphenolic contents of Guduchyadi kashaya, this study was conducted. The quantification of the polyphenols was carried out on Shimadzu Shim Pack GISS C18 column with .1%formic acid as mobile phase. A total of 28 polyphenolic compounds were analysed, and 24 of these compounds were found to be present in Guduchyadi kashaya. The results showed that the phenolic compounds present in the ingredients were also present in the formulation in high abundance.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3085
Athira V. Kottoor, Sunil John Thykkattil
Neurogenic bladder refers to dysfunction of the urinary bladder arising from internal or external trauma, disease, or injury of the central, autonomic or somatic nervous system in the control of micturition. Depending on the nerves involved and the nature of the damage, bladder becomes either overactive or underactive and this usually presents clinically as urinary incontinence or retention of urine. Urinary Incontinence (UI) is a hygienic problem and is one of the troublesome, important cause of morbidity and impairment of quality of life, in both men and women. It may lead to recurrent UTI and ascending infections which affect the functioning of kidney. Deranged function of Vatadosha especially Apanavata along with Pranavata and Vyanavata are the main culprits of neurogenic bladder. Vitiated Doshas cause Mootravahasrotodushti and Atipravritti of mootra. This case study discusses the effect of Mootramarga uttarabasti in reducing the signs and symptoms of neurogenic urinary incontinence and thereby improving the quality of life. A 66 year old male patient was admitted with weakness in left upper and lower limbs, slurred speech, and difficulty in controlling micturition since 5 months. He was a diagnosed case of stroke on the basis of a brain computed tomography scan. During the course of management, Uttarabasti was administered for 8 days with Dhanwantarataila and Balamoolakashaya alternatively. The intervention resulted in reducing the symptoms of neurogenic urinary incontinence as evidenced by the reduction in ICIQ-UI -SF score. It was observed that the overall impact of the disease was reduced and quality of life improved with the help of King’s Health Questionnaire (KHQ).
{"title":"Role of Uttarabasti in Neurogenic Urinary Incontinence","authors":"Athira V. Kottoor, Sunil John Thykkattil","doi":"10.47070/ijapr.v12i1.3085","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3085","url":null,"abstract":"Neurogenic bladder refers to dysfunction of the urinary bladder arising from internal or external trauma, disease, or injury of the central, autonomic or somatic nervous system in the control of micturition. Depending on the nerves involved and the nature of the damage, bladder becomes either overactive or underactive and this usually presents clinically as urinary incontinence or retention of urine. Urinary Incontinence (UI) is a hygienic problem and is one of the troublesome, important cause of morbidity and impairment of quality of life, in both men and women. It may lead to recurrent UTI and ascending infections which affect the functioning of kidney. Deranged function of Vatadosha especially Apanavata along with Pranavata and Vyanavata are the main culprits of neurogenic bladder. Vitiated Doshas cause Mootravahasrotodushti and Atipravritti of mootra. This case study discusses the effect of Mootramarga uttarabasti in reducing the signs and symptoms of neurogenic urinary incontinence and thereby improving the quality of life. A 66 year old male patient was admitted with weakness in left upper and lower limbs, slurred speech, and difficulty in controlling micturition since 5 months. He was a diagnosed case of stroke on the basis of a brain computed tomography scan. During the course of management, Uttarabasti was administered for 8 days with Dhanwantarataila and Balamoolakashaya alternatively. The intervention resulted in reducing the symptoms of neurogenic urinary incontinence as evidenced by the reduction in ICIQ-UI -SF score. It was observed that the overall impact of the disease was reduced and quality of life improved with the help of King’s Health Questionnaire (KHQ).","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"6 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3072
Arjun Ravi, Nafeesath Beevi. A, Jyothi.R
Overweight is defined as abnormal or excessive fat accumulation that presents a risk to health. Once considered a problem only in high-income countries, overweight and obesity are now dramatically on the rise in low and middle-income countries, particularly in urban settings. Overweight and obesity are the fifth greatest risk factors for death worldwide. Due to secondary consequences including obesity, type-2 diabetes mellitus, coronary heart disease, dyslipidemia, etc., the morbidity and mortality of overweight people are rising. Obesity and overweight are primarily caused by an imbalance in energy between calories consumed and calories burned. To maintain balance between the two, the management approach attempts to reduce energy intake while boosting energy expenditure. In Ayurveda, overweight can be correlated to Sthoulya. In this study an intervention along with addition of one dietary intervention was made into the daily routine of subjects. Here yoga is most suitable adaptation of physical activity and Mudgadi kashaya peya is a dietary preparation having Kapha medohara property which can reduce the over gaining weight and presence health.
{"title":"Effect of Mudgadi Kashaya Peya and Selected Yoga Techniques in Overweight","authors":"Arjun Ravi, Nafeesath Beevi. A, Jyothi.R","doi":"10.47070/ijapr.v12i1.3072","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3072","url":null,"abstract":"Overweight is defined as abnormal or excessive fat accumulation that presents a risk to health. Once considered a problem only in high-income countries, overweight and obesity are now dramatically on the rise in low and middle-income countries, particularly in urban settings. Overweight and obesity are the fifth greatest risk factors for death worldwide. Due to secondary consequences including obesity, type-2 diabetes mellitus, coronary heart disease, dyslipidemia, etc., the morbidity and mortality of overweight people are rising. Obesity and overweight are primarily caused by an imbalance in energy between calories consumed and calories burned. To maintain balance between the two, the management approach attempts to reduce energy intake while boosting energy expenditure. In Ayurveda, overweight can be correlated to Sthoulya. In this study an intervention along with addition of one dietary intervention was made into the daily routine of subjects. Here yoga is most suitable adaptation of physical activity and Mudgadi kashaya peya is a dietary preparation having Kapha medohara property which can reduce the over gaining weight and presence health.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3071
Athira V. Kottoor, Anjana D, Sunil John Thykattil
Pemphigus vegetans is a group of autoimmune disorder characterized by mucocutaneous bullae or pustules that erode to form hypertrophic papillated plaques that predominantly involve the scalp, and the face. It is the rarest variant of pemphigus vulgaris representing about 1-2% of all pemphigus. It may be correlated with Kardama visarpa in Ayurveda. The contemporary management of pemphigus is by systemic steroids. This case report of a 38 year old, male patient diagnosed with Pemphigus vegetans who presented with pustular lesions with foul smell, reddish spots with hypertrophic papillated lesions on scalp, itching and burning sensation over various body parts especially on upper parts since 20 years. He was treated with both Samana as well as Sodhana therapies for about 1 month. This condition was assessed using Pemphigus diseases area index. After treatment there was a significant reduction in the score. Moreover no new lesions were formed suggesting non progression of the diseases.
{"title":"Ayurvedic Management of Pemphigus Vegetans","authors":"Athira V. Kottoor, Anjana D, Sunil John Thykattil","doi":"10.47070/ijapr.v12i1.3071","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3071","url":null,"abstract":"Pemphigus vegetans is a group of autoimmune disorder characterized by mucocutaneous bullae or pustules that erode to form hypertrophic papillated plaques that predominantly involve the scalp, and the face. It is the rarest variant of pemphigus vulgaris representing about 1-2% of all pemphigus. It may be correlated with Kardama visarpa in Ayurveda. The contemporary management of pemphigus is by systemic steroids. This case report of a 38 year old, male patient diagnosed with Pemphigus vegetans who presented with pustular lesions with foul smell, reddish spots with hypertrophic papillated lesions on scalp, itching and burning sensation over various body parts especially on upper parts since 20 years. He was treated with both Samana as well as Sodhana therapies for about 1 month. This condition was assessed using Pemphigus diseases area index. After treatment there was a significant reduction in the score. Moreover no new lesions were formed suggesting non progression of the diseases.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3082
Gautami Isasare, Jyothi R, Nafeesath Beevi
Menopause is the term for the natural and permanent cessation of monthly female reproductive cycles. Menopausal women are known to experience physical, psychological, and vasomotor symptoms. In Ayurveda, menopause is not mentioned separately or as a disease but it is considered as Rajakshaya, the transition period of body from predominance of Pittadosha to Vatadosha. Rajonivritti (menopause) occurring in Jarapakva Shareer (aged body) at the age of 50 years. In modern science, hormone therapy has been used to control the symptoms of menopause. But long term use of this therapy had an increased risk for cardiovascular disease, stroke, breast cancer etc. A lifestyle modification is therefore an essential component in reducing menopausal symptoms, which includes a healthy diet, physical exercise, stress reduction and weight management. In this study 25 subjects with menopausal symptoms between the age group of 45 to 55 years were selected, from OPD of Govt. Ayurveda College Hospital, Tripunithura, as per the inclusion and exclusion criteria. The study subjects were advised to have two Yava saktu modakas of 10gm. each in morning at 7.30 a.m and the practice of Suryanamaskara and selected Pranayamas in the morning for 1 month. Assessment was done on 0th, 15th and 31st day of intervention. Along with this, the blood investigations like fasting blood sugar, post prandial blood sugar and serum cholesterol were assessed on 0th and 31st day of the study period. Results showed that Suryanamaskara, selected Pranayama and Yava saktu modaka have statistical significance in reducing menopausal symptoms.
{"title":"Effect of Suryanamaskara, Selected Pranayama and Yava Saktu Modaka in Menopausal Symptoms","authors":"Gautami Isasare, Jyothi R, Nafeesath Beevi","doi":"10.47070/ijapr.v12i1.3082","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3082","url":null,"abstract":"Menopause is the term for the natural and permanent cessation of monthly female reproductive cycles. Menopausal women are known to experience physical, psychological, and vasomotor symptoms. In Ayurveda, menopause is not mentioned separately or as a disease but it is considered as Rajakshaya, the transition period of body from predominance of Pittadosha to Vatadosha. Rajonivritti (menopause) occurring in Jarapakva Shareer (aged body) at the age of 50 years. In modern science, hormone therapy has been used to control the symptoms of menopause. But long term use of this therapy had an increased risk for cardiovascular disease, stroke, breast cancer etc. A lifestyle modification is therefore an essential component in reducing menopausal symptoms, which includes a healthy diet, physical exercise, stress reduction and weight management. In this study 25 subjects with menopausal symptoms between the age group of 45 to 55 years were selected, from OPD of Govt. Ayurveda College Hospital, Tripunithura, as per the inclusion and exclusion criteria. The study subjects were advised to have two Yava saktu modakas of 10gm. each in morning at 7.30 a.m and the practice of Suryanamaskara and selected Pranayamas in the morning for 1 month. Assessment was done on 0th, 15th and 31st day of intervention. Along with this, the blood investigations like fasting blood sugar, post prandial blood sugar and serum cholesterol were assessed on 0th and 31st day of the study period. Results showed that Suryanamaskara, selected Pranayama and Yava saktu modaka have statistical significance in reducing menopausal symptoms.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"23 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139867369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3086
Nidhi Patel, Bharti Umrethia
Shelf life means the time period during which the potency of a drug remains unaffected from environmental factors or microbial contamination. Nowadays diverse procedures of making powder are available which affect on shelf life of them. Ocimum sanctum L. is most common household herb in Indian subcontinent. Hence, the present study is aimed to develop analytical profile of Ocimum sanctum L. leaves powder by classical and lyophilized method and compare the stability of both the samples. Materials and Methods: Ocimum sanctum L. leaves powder was prepared by two different drying methods and accelerated stability study was conducted as per ICH guideline Q1A (R2). Physicochemical analysis was repeated at interval of 0, 1, 3 and 6 months. Organoleptic parameters, microbial limits and heavy-metal analysis were observed at specific intervals. Result and Discussion: No significant changes were observed in organoleptic characters of both the samples up to storage of 6 months at accelerated condition. The values of physicochemical parameters of both the samples were within the prescribed limit specified in Ayurvedic Pharmacopeia of India. Results of Microbiological limit test were also below the limit and considerably decreased at specific intervals. Heavy metals namely arsenic, cadmium and mercury were not detected and lead was present below detectable limits. Conclusion: Analysis revealed that the classically prepared powder has better shelf life (3.08 years) than lyophilized powder (2.70 years) and also provides the modest and effective ways for optimal Eugenol extraction in accelerated conditions.
{"title":"Development of Analytical Profile of Ocimum sanctum L. leaves Powder prepared by Classical and Lyophilization method through Accelerated Stability Studies","authors":"Nidhi Patel, Bharti Umrethia","doi":"10.47070/ijapr.v12i1.3086","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3086","url":null,"abstract":"Shelf life means the time period during which the potency of a drug remains unaffected from environmental factors or microbial contamination. Nowadays diverse procedures of making powder are available which affect on shelf life of them. Ocimum sanctum L. is most common household herb in Indian subcontinent. Hence, the present study is aimed to develop analytical profile of Ocimum sanctum L. leaves powder by classical and lyophilized method and compare the stability of both the samples. Materials and Methods: Ocimum sanctum L. leaves powder was prepared by two different drying methods and accelerated stability study was conducted as per ICH guideline Q1A (R2). Physicochemical analysis was repeated at interval of 0, 1, 3 and 6 months. Organoleptic parameters, microbial limits and heavy-metal analysis were observed at specific intervals. Result and Discussion: No significant changes were observed in organoleptic characters of both the samples up to storage of 6 months at accelerated condition. The values of physicochemical parameters of both the samples were within the prescribed limit specified in Ayurvedic Pharmacopeia of India. Results of Microbiological limit test were also below the limit and considerably decreased at specific intervals. Heavy metals namely arsenic, cadmium and mercury were not detected and lead was present below detectable limits. Conclusion: Analysis revealed that the classically prepared powder has better shelf life (3.08 years) than lyophilized powder (2.70 years) and also provides the modest and effective ways for optimal Eugenol extraction in accelerated conditions.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139806365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.3065
J M Urvashiba, BN Ashok Kumar, A Ravindra, V S Sushmitha, P R R Geethesh
Infections can be caused by a wide range of pathogens and bacteria are one among them. Presently, we confront a significant challenge concerning antimicrobial resistance, leading the world to explore alternative medicine as a potential solution. Bhasmeshwara rasa is a formulation mentioned under Sannipataja jwara chikitsa in Rasendra Chintamani which acts on all three Doshas. It is a Khalviya Rasayana containing Vanyopala bhasma (cow dung cake Bhasma), Maricha and Shuddha vatsanabha and its Anupana is Ardraka Swarasa. Even though there is no Parada used in this formulation, still this formulation is suffixed with “Rasa” in its name Bhasmeshwara. In vitro anti-bacterial study, the action of Bhasmeshwara rasa was tested against Salmonella typhi by well diffusion method. A combination of Bhasmeshwara Rasa and Ardraka Swarasa showed antibacterial activity against Salmonella typhi. Hence, with the present study, it can be concluded that Bhasmeshwara Rasa and Ardraka Swarasa combination shows mild to moderate anti-bacterial activity.
{"title":"An Antimicrobial Evaluation of Bhasmeshwara Rasa on Salmonella Typhi","authors":"J M Urvashiba, BN Ashok Kumar, A Ravindra, V S Sushmitha, P R R Geethesh","doi":"10.47070/ijapr.v12i1.3065","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.3065","url":null,"abstract":"Infections can be caused by a wide range of pathogens and bacteria are one among them. Presently, we confront a significant challenge concerning antimicrobial resistance, leading the world to explore alternative medicine as a potential solution. Bhasmeshwara rasa is a formulation mentioned under Sannipataja jwara chikitsa in Rasendra Chintamani which acts on all three Doshas. It is a Khalviya Rasayana containing Vanyopala bhasma (cow dung cake Bhasma), Maricha and Shuddha vatsanabha and its Anupana is Ardraka Swarasa. \u0000Even though there is no Parada used in this formulation, still this formulation is suffixed with “Rasa” in its name Bhasmeshwara. In vitro anti-bacterial study, the action of Bhasmeshwara rasa was tested against Salmonella typhi by well diffusion method. A combination of Bhasmeshwara Rasa and Ardraka Swarasa showed antibacterial activity against Salmonella typhi. Hence, with the present study, it can be concluded that Bhasmeshwara Rasa and Ardraka Swarasa combination shows mild to moderate anti-bacterial activity.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"2007 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-04DOI: 10.47070/ijapr.v12i1.2838
Haris M.S, Sreeni T.V
Phanta Kalpana, the process of herbal hot infusion is one of the five fundamental Ayurvedic preparations. A unique Kalpana is specifically mentioned for those with a minor illness, little strength, and younger age. However, this Kalpana is not widely utilizing because of the unavailability of scientific data and uncertainty about its action. Even though it is a simple Kalpana while analyzing available references numerous differences were determined among Ayurvedic classics. Differences of opinion or expression of comments noted in drug to water ratio, order mixing of water and drug, temperature of the water, time of contact, Powder size, and the need for stir and strain. Different experiments were conducted based on these parameters. And it shows their significance. In addition, a market sample examination of two separate Kashaya Choornas of two companies produced results with completely different powder sizes. Product output will vary due to these practical variations unless later changes are made to other parameters. Comparative physiochemical and phytochemical analyses of Kashaya and Phanta Kashaya were done. Values are almost similar except for total solid content and GCMS. Total solid rises along with the reduction in Kashya. Total phenolic and flavonoid contents show almost similar values, whereas GCMS analysis shows peaks of some molecules in Phanta Kashaya and peaks of some other molecules in Kashaya Kalpana. So, each of these two Kalpana favors solubilizing and makes bioavailable different ranges of biomolecules. So, each of these Kalpana has a different and specific utility and function.
{"title":"Critical Review of Phanta Kalpana and Phytochemical Comparison of Panchakola Phanta with Panchakola Kashaya","authors":"Haris M.S, Sreeni T.V","doi":"10.47070/ijapr.v12i1.2838","DOIUrl":"https://doi.org/10.47070/ijapr.v12i1.2838","url":null,"abstract":"Phanta Kalpana, the process of herbal hot infusion is one of the five fundamental Ayurvedic preparations. A unique Kalpana is specifically mentioned for those with a minor illness, little strength, and younger age. However, this Kalpana is not widely utilizing because of the unavailability of scientific data and uncertainty about its action. Even though it is a simple Kalpana while analyzing available references numerous differences were determined among Ayurvedic classics. Differences of opinion or expression of comments noted in drug to water ratio, order mixing of water and drug, temperature of the water, time of contact, Powder size, and the need for stir and strain. Different experiments were conducted based on these parameters. And it shows their significance. In addition, a market sample examination of two separate Kashaya Choornas of two companies produced results with completely different powder sizes. Product output will vary due to these practical variations unless later changes are made to other parameters. Comparative physiochemical and phytochemical analyses of Kashaya and Phanta Kashaya were done. Values are almost similar except for total solid content and GCMS. Total solid rises along with the reduction in Kashya. Total phenolic and flavonoid contents show almost similar values, whereas GCMS analysis shows peaks of some molecules in Phanta Kashaya and peaks of some other molecules in Kashaya Kalpana. So, each of these two Kalpana favors solubilizing and makes bioavailable different ranges of biomolecules. So, each of these Kalpana has a different and specific utility and function.","PeriodicalId":13913,"journal":{"name":"International Journal of Ayurveda and Pharma Research","volume":"2017 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139806961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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