Pub Date : 2020-01-31DOI: 10.18311/ijmds/2020/24306
S. Shetty, Aishwarya Kamble, F. Katge, K. Nanavati
Odontomas are odontogenic benign tumours composed of enamel, dentine, cementum, and pulp like tissue which are generally discovered during diagnostic radiography and are often asymptomatic. According to World Health Organisation (WHO), odontoma are classified as compound and complex odontomas. Compound or complex odontoma are commonly reported in the oral cavity but very rarely an odontoma may show features of both. This paper reports a rare case of an odontoma with both compound and complex features, occurring in the upper front region of the jaw associated with impaction of right permanent maxillary central incisor.
{"title":"Complex Compound Odontoma Associated with an Unerupted Tooth: A Rare Entity","authors":"S. Shetty, Aishwarya Kamble, F. Katge, K. Nanavati","doi":"10.18311/ijmds/2020/24306","DOIUrl":"https://doi.org/10.18311/ijmds/2020/24306","url":null,"abstract":"Odontomas are odontogenic benign tumours composed of enamel, dentine, cementum, and pulp like tissue which are generally discovered during diagnostic radiography and are often asymptomatic. According to World Health Organisation (WHO), odontoma are classified as compound and complex odontomas. Compound or complex odontoma are commonly reported in the oral cavity but very rarely an odontoma may show features of both. This paper reports a rare case of an odontoma with both compound and complex features, occurring in the upper front region of the jaw associated with impaction of right permanent maxillary central incisor.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91262693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Retinopathy of Prematurity (ROP) is a disease where development of abnormal retinal vessels occurs because of incomplete vascularization of the retinal tissue. With advancement in the field of neonatology now more premature babies and Very-Low-Birth-Weight (VLBW) infants surviving and incidence of retinopathy of prematurity is increasing. ROP screening should be done in all premature babies. Objectives: To Study the Risk Factors for Retinopathy of Prematurity in Premature Born infants at tertiary care centre. Methods: This study was done on 75 newborns infants and were included in study after satisfying the inclusion criteria. The following criteria were studied: gestational age≤34 weeks or BW≤1500 grams, along with neonates with more birth weight and higher gestational age having risk factors like : low Apgar score, duration of oxygen supplementation more than 10 days, sepsis, more than one blood transfusion, respiratory distress. Characteristics of newborns including risk factors, and pattern of severe ROP were assessed from Punjab region of India. Result: Total of 75 newborns included in the study, 53 were males (70.66%) and 22 were (29.33%) females. The analysis of gestational age showed that the mean age was 29.9±2.9 weeks, the youngest one was of 27 weeks and the oldest was 37 weeks of gestation. The average birth weight was 1350±510 grams, with lowest 675 gm and highest 3100 grams. Conclusion: The most common risk factors that are associated with development of ROP revealed gestational age, Apgar score in the first minute, birth weight, duration of oxygen therapy and the blood transfusion.
{"title":"Evaluation of Risk Factors for Retinopathy of Prematurity in Premature Born Infants in Tertiary Care Centre in Punjab","authors":"Jatinder Singh, Vaneeta Bhardwar, Harshdhawann Singh, Isha Bhardwaj, Sushmita Choudhary, Alka Toora","doi":"10.18311/ijmds/2020/24651","DOIUrl":"https://doi.org/10.18311/ijmds/2020/24651","url":null,"abstract":"Background: Retinopathy of Prematurity (ROP) is a disease where development of abnormal retinal vessels occurs because of incomplete vascularization of the retinal tissue. With advancement in the field of neonatology now more premature babies and Very-Low-Birth-Weight (VLBW) infants surviving and incidence of retinopathy of prematurity is increasing. ROP screening should be done in all premature babies. Objectives: To Study the Risk Factors for Retinopathy of Prematurity in Premature Born infants at tertiary care centre. Methods: This study was done on 75 newborns infants and were included in study after satisfying the inclusion criteria. The following criteria were studied: gestational age≤34 weeks or BW≤1500 grams, along with neonates with more birth weight and higher gestational age having risk factors like : low Apgar score, duration of oxygen supplementation more than 10 days, sepsis, more than one blood transfusion, respiratory distress. Characteristics of newborns including risk factors, and pattern of severe ROP were assessed from Punjab region of India. Result: Total of 75 newborns included in the study, 53 were males (70.66%) and 22 were (29.33%) females. The analysis of gestational age showed that the mean age was 29.9±2.9 weeks, the youngest one was of 27 weeks and the oldest was 37 weeks of gestation. The average birth weight was 1350±510 grams, with lowest 675 gm and highest 3100 grams. Conclusion: The most common risk factors that are associated with development of ROP revealed gestational age, Apgar score in the first minute, birth weight, duration of oxygen therapy and the blood transfusion.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"34 1","pages":"1859-1863"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86417607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.18311/ijmds/2020/23626
Vaneeta Bhardwar, Neha Batra, U. Bandlish, M. Kaur
Background: Anemia is a condition in which the hemoglobin concentration in the blood is decreased, below the normal range. Peripheral blood smear examination and Bone marrow examinations are the two major tests done to evaluate anaemia. Materials and Methods: Study was conducted in Department of Pathology at PIMS Jalandhar. Total 100 patients having anemia (HB < 8gm%) was studied using PBF, Bone marrow aspiration and biopsy. A random and non-consecutive selection of 100 anemic patients was done amongst the anemic population to study the pattern and causes of anemia. Result: This study showed that females form the majority of patients suffering from anemia. It can be the result of various causes; nutritional deficiency forms the majority of those causes. Conclusion: The present study found out high prevalence of anemia in both males and females. Anemia can be the presenting sign of various disorders which can be evaluated by Bone marrow examination.
{"title":"Prevalence of Different Types of Anaemias in Patients having Haemoglobin below 8gm% at a Tertiary Care Hospital in Jalandhar","authors":"Vaneeta Bhardwar, Neha Batra, U. Bandlish, M. Kaur","doi":"10.18311/ijmds/2020/23626","DOIUrl":"https://doi.org/10.18311/ijmds/2020/23626","url":null,"abstract":"Background: Anemia is a condition in which the hemoglobin concentration in the blood is decreased, below the normal range. Peripheral blood smear examination and Bone marrow examinations are the two major tests done to evaluate anaemia. Materials and Methods: Study was conducted in Department of Pathology at PIMS Jalandhar. Total 100 patients having anemia (HB < 8gm%) was studied using PBF, Bone marrow aspiration and biopsy. A random and non-consecutive selection of 100 anemic patients was done amongst the anemic population to study the pattern and causes of anemia. Result: This study showed that females form the majority of patients suffering from anemia. It can be the result of various causes; nutritional deficiency forms the majority of those causes. Conclusion: The present study found out high prevalence of anemia in both males and females. Anemia can be the presenting sign of various disorders which can be evaluated by Bone marrow examination.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85197598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.18311/ijmds/2020/24477
N. Grewal, J. K. Bajaj, M. Sood
Background: Mobile phone culture has brought about a revolution in technology and people of all age groups (especially youngsters) have become greatly dependant on mobiles for various reasons. It has become an integral part of routine work of students who rely on mobiles for academic purposes also. This study was planned to evaluate the impact of mobile phone use on health and academic performance of MBBS students. Methods: It was cross sectional questionnaire based study in which 300 MBBS students were involved. Various questions regarding mobile usage, associated benefits and problems pertaining to academic activities and impact on health were filled and tabulated in ranges and percentages. Results: All the students involved in study used mobile phones and their usage ranged from 0.2-6.5 hrs on a working day and0.5-8 hrs on holiday. Many students reported increased academic performance with the help of mobiles whereas few students reported disturbance in class, impaired concentration and increased use of abbreviations in routine. Also, students reported certain health issues like changes in vision, pain in wrist, neck and preference to stay alone with use of mobile phones. Conclusions: Excessive use of mobile phones can have deleterious effects on human mind and brain. Plethora of physical, psychological and behavioural problems can be seen with long term use of handsets. With advancements in technologies, associated risks are also bound to increase. So judicious and wise use of mobiles is a must to avoid harmful consequences in youngsters especially students.
{"title":"Impact of Mobile Phone usage on Academic Performance and Behaviour of Medical Students","authors":"N. Grewal, J. K. Bajaj, M. Sood","doi":"10.18311/ijmds/2020/24477","DOIUrl":"https://doi.org/10.18311/ijmds/2020/24477","url":null,"abstract":"Background: Mobile phone culture has brought about a revolution in technology and people of all age groups (especially youngsters) have become greatly dependant on mobiles for various reasons. It has become an integral part of routine work of students who rely on mobiles for academic purposes also. This study was planned to evaluate the impact of mobile phone use on health and academic performance of MBBS students. Methods: It was cross sectional questionnaire based study in which 300 MBBS students were involved. Various questions regarding mobile usage, associated benefits and problems pertaining to academic activities and impact on health were filled and tabulated in ranges and percentages. Results: All the students involved in study used mobile phones and their usage ranged from 0.2-6.5 hrs on a working day and0.5-8 hrs on holiday. Many students reported increased academic performance with the help of mobiles whereas few students reported disturbance in class, impaired concentration and increased use of abbreviations in routine. Also, students reported certain health issues like changes in vision, pain in wrist, neck and preference to stay alone with use of mobile phones. Conclusions: Excessive use of mobile phones can have deleterious effects on human mind and brain. Plethora of physical, psychological and behavioural problems can be seen with long term use of handsets. With advancements in technologies, associated risks are also bound to increase. So judicious and wise use of mobiles is a must to avoid harmful consequences in youngsters especially students.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83358692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.18311/ijmds/2020/24452
Mahmoud M Al Ankily, M. Shamel, Mahmoud M. Bakr
Diabetes has well known damaging effects on different tissues of the body including salivary glands. Epidermal Growth Factor (EGF) facilitates healing and repair through different mechanisms including the increase in the activation and proliferation of fibroblasts. The aim of this study was to investigate if the effect of EGF was enough to repair the damage caused by diabetes in streptozotocin induced diabetic rats. Sixty adult male albino rats were divided into three groups. A control group, a streptozotocin induced diabetic group, and EGF group that was subjected to a single daily EGF intraperitoneal injection for two months after induction of diabetes. Submandibular salivary glands were dissected and examined using transmission electron microscopy. The diabetic group showed severe signs of atrophy and damage affecting all glandular components. The EGF group showed marked improvement in all elements of the submandibular salivary glands. Conclusions: EGF restored the structural integrity of submandibular salivary glands in diabetic rats.
{"title":"Epidermal Growth Factor Improves the Ultrastructure of Submandibular Salivary Glands of Streptozotocin Induced Diabetic Rats - A Qualitative Study","authors":"Mahmoud M Al Ankily, M. Shamel, Mahmoud M. Bakr","doi":"10.18311/ijmds/2020/24452","DOIUrl":"https://doi.org/10.18311/ijmds/2020/24452","url":null,"abstract":"Diabetes has well known damaging effects on different tissues of the body including salivary glands. Epidermal Growth Factor (EGF) facilitates healing and repair through different mechanisms including the increase in the activation and proliferation of fibroblasts. The aim of this study was to investigate if the effect of EGF was enough to repair the damage caused by diabetes in streptozotocin induced diabetic rats. Sixty adult male albino rats were divided into three groups. A control group, a streptozotocin induced diabetic group, and EGF group that was subjected to a single daily EGF intraperitoneal injection for two months after induction of diabetes. Submandibular salivary glands were dissected and examined using transmission electron microscopy. The diabetic group showed severe signs of atrophy and damage affecting all glandular components. The EGF group showed marked improvement in all elements of the submandibular salivary glands. Conclusions: EGF restored the structural integrity of submandibular salivary glands in diabetic rats.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"2 1","pages":"1803-1810"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90134565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-31DOI: 10.18311/ijmds/2020/24644
A. Sehgal, V. Sehgal
{"title":"Metformin beyond Diabetes","authors":"A. Sehgal, V. Sehgal","doi":"10.18311/ijmds/2020/24644","DOIUrl":"https://doi.org/10.18311/ijmds/2020/24644","url":null,"abstract":"","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80185081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-11DOI: 10.18311/IJMDS/2019/23420
V. Sehgal, Tushar Vashisht, Gursatinder Singh, N. Sharma
Aim: A pharmacoeconomic analysis to determine the relative cost-effectiveness of timolol 0.5%, brinzolamide 1% and brimonidine 0.2% eye drops in treatment of Primary Open Angle Glaucoma (POAG)/ocular hypertension (OHT). Settings and Design: Comparative, open, randomized, parallel group prospective study. Materials and Methods: 60 patients of POAG or ocular hypertension were included in this study. Time period of study was 6 weeks. 60 eyes of 60 patients were included in the study. Patients were divided randomly into 3 groups of 20 each. Patients in group A, B and C received timolol, brinzolamide and brimonidine respectively. One drop of each medication was instilled twice a day at 9 am and 9 pm daily for 6 weeks. IOP was measured on day 0 at 9 am (before administration of drugs) and then at 11 am, to get baseline IOP. IOP was again measured on subsequent visits at 9 am and 11 am. Treatment outcome was number of mm Hg fall in IOP induced by the study drug. The daily cost of each drug was calculated by maximum retail price and the average number of drops per bottle. The cost‑effectiveness was then calculated as the cost of drug/mm Hg fall in IOP. Statistics: Paired ‘t’ test was used to analyze the parameters within the group. Independent samples t‑test was used to compare the efficacy of drugs with each other. Results: The % reduction of brimonidine, timolol and brinzolamide at end of 6 weeks was 21.43 ± 3.06%, 24.87 ± 2.46% and 18.78 ± 1.73% respectively. Timolol was superior in efficacy to other two drugs. The difference was statistically significant between the efficacy of timolol and brinzolamide (p < 0.001) as well as timolol and brimonidine (p = 0.003). There was no statistical significant difference in the efficacy of brimonidine when compared to brinzolamide (p=0.26). Timolol (5.87 ± 0.83 Rs/mm lowering after 6 weeks) was found to be most cost-effective followed by brimonidine (46.83 ± 7.37) and then brinzolamide (60.49 ± 6.77) in lowering IOP. Conclusion: All three drugs under the present study are useful in the treatment of POAG/OHT, but timolol is a better choice than other two drugs because of greater reduction in IOP and greater cost-effectiveness.
{"title":"A Pharmacoeconomic Analysis to Determine the Relative Cost-effectiveness of Timolol 0.5%, Brinzolamide 1% and Brimonidine 0.2% Eye Drops in Treatment of Primary Open Angle Glaucoma/Ocular Hypertension","authors":"V. Sehgal, Tushar Vashisht, Gursatinder Singh, N. Sharma","doi":"10.18311/IJMDS/2019/23420","DOIUrl":"https://doi.org/10.18311/IJMDS/2019/23420","url":null,"abstract":"Aim: A pharmacoeconomic analysis to determine the relative cost-effectiveness of timolol 0.5%, brinzolamide 1% and brimonidine 0.2% eye drops in treatment of Primary Open Angle Glaucoma (POAG)/ocular hypertension (OHT). Settings and Design: Comparative, open, randomized, parallel group prospective study. Materials and Methods: 60 patients of POAG or ocular hypertension were included in this study. Time period of study was 6 weeks. 60 eyes of 60 patients were included in the study. Patients were divided randomly into 3 groups of 20 each. Patients in group A, B and C received timolol, brinzolamide and brimonidine respectively. One drop of each medication was instilled twice a day at 9 am and 9 pm daily for 6 weeks. IOP was measured on day 0 at 9 am (before administration of drugs) and then at 11 am, to get baseline IOP. IOP was again measured on subsequent visits at 9 am and 11 am. Treatment outcome was number of mm Hg fall in IOP induced by the study drug. The daily cost of each drug was calculated by maximum retail price and the average number of drops per bottle. The cost‑effectiveness was then calculated as the cost of drug/mm Hg fall in IOP. Statistics: Paired ‘t’ test was used to analyze the parameters within the group. Independent samples t‑test was used to compare the efficacy of drugs with each other. Results: The % reduction of brimonidine, timolol and brinzolamide at end of 6 weeks was 21.43 ± 3.06%, 24.87 ± 2.46% and 18.78 ± 1.73% respectively. Timolol was superior in efficacy to other two drugs. The difference was statistically significant between the efficacy of timolol and brinzolamide (p < 0.001) as well as timolol and brimonidine (p = 0.003). There was no statistical significant difference in the efficacy of brimonidine when compared to brinzolamide (p=0.26). Timolol (5.87 ± 0.83 Rs/mm lowering after 6 weeks) was found to be most cost-effective followed by brimonidine (46.83 ± 7.37) and then brinzolamide (60.49 ± 6.77) in lowering IOP. Conclusion: All three drugs under the present study are useful in the treatment of POAG/OHT, but timolol is a better choice than other two drugs because of greater reduction in IOP and greater cost-effectiveness.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83030165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-11DOI: 10.18311/IJMDS/2019/23313
S. Chattopadhyay, T. Biswas, Bipasa Chakraborty, T. Mukherjee, Purbasha Ghosh, Raston Mondal
Assistant Professor, Department of Microbiology, Burdwan Medical College and Hospital, Purba Barddhaman – 713104, West Bengal, India; dr.saswatichattopadhyay@gmail.com, tmukherjee2008@gmail.com, purbashaghosh02@gmail.com Associate Professor, Department of Microbiology, IPGME&R, Kolkata – 700020, West Bengal, India; dr.tanusribiswas@rediffmail.com Assistant Professor, Department of Microbiology, R. G. Kar Medical College, Kolkata – 700004, West Bengal, India; bipasa_doc@yahoo.co.in Assistant Professor, Department of Community Medicine, Burdwan Medical College, Purba Bardhaman 713104, West Bengal, India; rastonmondal@rediffmail.com
布尔德万医学院和医院微生物学系助理教授，印度西孟加拉邦普尔巴巴德曼- 713104;dr.saswatichattopadhyay@gmail.com, tmukherjee2008@gmail.com, purbashaghosh02@gmail.com印度西孟加拉邦加尔各答- 700020,IPGME&R微生物学系副教授;dr.tanusribiswas@rediffmail.com R. G. Kar医学院微生物系助理教授，印度西孟加拉邦加尔各答- 700004;bipasa_doc@yahoo.co.in布尔德万医学院社区医学系助理教授，印度西孟加拉邦普尔巴巴德曼713104;rastonmondal@rediffmail.com
{"title":"Sero-prevalence of Rubella Antibodies in Pregnant Women with Bad Obstetric History Attending A Rural Tertiary Care Hospital in West Bengal, India","authors":"S. Chattopadhyay, T. Biswas, Bipasa Chakraborty, T. Mukherjee, Purbasha Ghosh, Raston Mondal","doi":"10.18311/IJMDS/2019/23313","DOIUrl":"https://doi.org/10.18311/IJMDS/2019/23313","url":null,"abstract":"Assistant Professor, Department of Microbiology, Burdwan Medical College and Hospital, Purba Barddhaman – 713104, West Bengal, India; dr.saswatichattopadhyay@gmail.com, tmukherjee2008@gmail.com, purbashaghosh02@gmail.com Associate Professor, Department of Microbiology, IPGME&R, Kolkata – 700020, West Bengal, India; dr.tanusribiswas@rediffmail.com Assistant Professor, Department of Microbiology, R. G. Kar Medical College, Kolkata – 700004, West Bengal, India; bipasa_doc@yahoo.co.in Assistant Professor, Department of Community Medicine, Burdwan Medical College, Purba Bardhaman 713104, West Bengal, India; rastonmondal@rediffmail.com","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"525 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83292649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-11DOI: 10.18311/IJMDS/2019/20943
S. Arora, V. Sehgal, Jasbir Singh, Harcharan Singh
Background: Hypertension(HTN) is a major cardiovascular disease and is a major worldwide clinical problem. The prevalence of hypertension increases in urban and rural areas. The treatment of hypertension began in the 1960s with oral diuretics. The other modalities of treatment of hypertension are beta – blockers, calcium-channel blockers, alphareceptors blockers, ACE inhibitors and ARBs. The better compliance occurs with single-pill combination, and may be even double or even triple pill combination therapy should be used. Also quality of life was improved better with Metoprolol and Telmisartan as compared with Metoprolol and Ramipril. Quality of life was assessed by SF -36 Quiestionnare. Objective: To compare the effect of Metoprolol and Telmisartan versus Metoprolol and Ramipril on BP and quality of life in patients of hypertension. Material and Methods: In this prospective, open, randomized, parallel group, comparative study, 80 patients of hypertension attending the Cardiology Outpatient Department, Govt. Medical College & Rajindra Hospital, Patiala were recruited. This randomized comparative study was done on 80 patients for 4 months. Quality of Life: In my project of Quality of life, I had taken total 80 patients and the patients were divided into two groups and 40 patients each of Metoprolol and Ramipril versus Metoprolol and Telmisartan. To assess quality of life questionnaire SF-36 was administered to the patients. Results: There was a marked decrease in SBP and DBP with the use of Metoprolol and Telmisartan than Metoprolol and Ramipril. There was also no change in demographic parameters. There was significant improvement in the quality of life with Metoprolol and Telmisartan. Conclusion: Metoprolol and Telmisartan was a better choice than Metoprolol and Ramipril in treating hypertension as this combination causes more reduction in BP and little effect on HR.
{"title":"Comparative Study to Evaluate Efficacy, Safety and Quality of Life of Metoprolol and Telmisartan versus Metoprolol and Ramipril in Patients of Hypertension","authors":"S. Arora, V. Sehgal, Jasbir Singh, Harcharan Singh","doi":"10.18311/IJMDS/2019/20943","DOIUrl":"https://doi.org/10.18311/IJMDS/2019/20943","url":null,"abstract":"Background: Hypertension(HTN) is a major cardiovascular disease and is a major worldwide clinical problem. The prevalence of hypertension increases in urban and rural areas. The treatment of hypertension began in the 1960s with oral diuretics. The other modalities of treatment of hypertension are beta – blockers, calcium-channel blockers, alphareceptors blockers, ACE inhibitors and ARBs. The better compliance occurs with single-pill combination, and may be even double or even triple pill combination therapy should be used. Also quality of life was improved better with Metoprolol and Telmisartan as compared with Metoprolol and Ramipril. Quality of life was assessed by SF -36 Quiestionnare. Objective: To compare the effect of Metoprolol and Telmisartan versus Metoprolol and Ramipril on BP and quality of life in patients of hypertension. Material and Methods: In this prospective, open, randomized, parallel group, comparative study, 80 patients of hypertension attending the Cardiology Outpatient Department, Govt. Medical College & Rajindra Hospital, Patiala were recruited. This randomized comparative study was done on 80 patients for 4 months. Quality of Life: In my project of Quality of life, I had taken total 80 patients and the patients were divided into two groups and 40 patients each of Metoprolol and Ramipril versus Metoprolol and Telmisartan. To assess quality of life questionnaire SF-36 was administered to the patients. Results: There was a marked decrease in SBP and DBP with the use of Metoprolol and Telmisartan than Metoprolol and Ramipril. There was also no change in demographic parameters. There was significant improvement in the quality of life with Metoprolol and Telmisartan. Conclusion: Metoprolol and Telmisartan was a better choice than Metoprolol and Ramipril in treating hypertension as this combination causes more reduction in BP and little effect on HR.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80041088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-11DOI: 10.18311/IJMDS/2019/23418
Faiziul Haq, Harinder Singh, V. Sehgal, Sanjeev Kumar, A. Kaur
Introduction: Hypertension is a multi-factorial and complex disease that has both environmental and genetic determinants. It is the single most significant risk factor for heart diseases and kidney diseases. Hypertension is a leading contributor to global burden of morbidity and mortality. It is considered as a silent killer because most of the time it is asymptomatic and goes undetected. Hence, hypertensive patients should be prescribed properly. Objectives: To evaluate the prescribing pattern of anti-hypertensive drugs in patients of hypertension. Material and Methods: This was an observational, cross sectional study conducted over a period of 1 year on hypertensive patients attending the Cardiology out-patient department of Government Medical College and Rajindra Hospital, Patiala and fulfilling the inclusion and exclusion criteria. The prescriptions were evaluated. Results: 22% of prescriptions had monotherapy, amongst which beta-blockers were most commonly prescribed. Majority of prescriptions had two drug therapy (47%), among which ARB+ beta blockers (17%) were most frequently prescribed. Beta blockers +CCB (9%) was the most common Fixed Drug Combination (FDC) prescribed. ARB+beta blockers+diuretics (14%) and ACEI+ARB+beta blockers+diuretics (1%) were most commonly prescribed three drug combinations. Among four drug combinations, only ACEI+ARB+beta blockers+diuretics was prescribed to 1% patients. Hypolipidemic drugs (66%) were maximally co-prescribed. Conclusions: A high trend of polypharmacy was observed in hypertensive patients. So, emphasis is needed to reevaluate the prescribing trends in these patients.
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