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Oral Rehabilitation in Neurofibromatosis Type 1- A Six Year Follow-Up Case Report 1型神经纤维瘤病口腔康复6年随访病例报告
Pub Date : 2021-01-29 DOI: 10.18311/IJMDS/2021/26284
Somnath Pralhad Pachrupe, M. Phadnaik, Pooja Gupta
Neurofibromatosis is an autosomal dominant disorder that affects the bone, the nervous system, soft-tissue, and the skin. The expressivity of the disease is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. The penetrance, otherwise, is 100%. Approximately 72% of Neurofibromatosis Type1 patients present with oral manifestations. These patients have an estimated 3-15% additional risk of malignant disease in their life-time. The following report presents a 32 year old lady diagnosed with Neurofibromatosis Type 1 in childhood who presented to department with complain of bleeding gums. Radiograph showed shallow sigmoid notch on left side, obtuse and thinned out left angle of mandible which are some additional features. A multidisciplinary approach of dental and medical specialties was taken here for oral rehabilitation and to manage and treat periodontal manifestations and other oral complaints. Case was followed for more than 6 years. Neurofibromatosis has no cure hence when such patients report to dental professionals it is up to them to act as primary care giver and instill positive frame of mind to help reduce stressful life events.
神经纤维瘤病是一种常染色体显性遗传病,影响骨骼、神经系统、软组织和皮肤。该疾病的表现非常多变,表现范围从轻度病变到几种并发症和功能损害。否则,外显率为100%。大约72%的1型神经纤维瘤病患者表现为口腔表现。据估计,这些患者一生中患恶性疾病的风险增加3-15%。下面的报告提出了一个32岁的妇女诊断为1型神经纤维瘤病在儿童谁提出的部门抱怨牙龈出血。x线片显示左侧乙状切口浅,下颌骨左角钝角变薄,这是一些附加特征。这里采用牙科和医学专业的多学科方法进行口腔康复,管理和治疗牙周表现和其他口腔疾患。病例随访6年以上。神经纤维瘤病无法治愈,因此,当这些患者向牙科专业人员报告时,他们需要作为初级护理提供者,并灌输积极的心态,以帮助减少压力生活事件。
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引用次数: 0
Acute arsenic suicidal poisoning – a rare case 急性砷自杀中毒——罕见病例
Pub Date : 2021-01-29 DOI: 10.18311/IJMDS/2021/26466
R. Rajavardhan, Anand Mamadapur, N. Shyamala
Arsenic is a naturally occurring element in the earth's crust. Chronic arsenic poisoning has been regularly reported predominantly due to occupational exposure in the literature. Acute arsenic poisoning is very rare. A 27-year-old gentleman was brought to the hospital with a history of suicide attempt by consumption of arsenic trioxide diluted in water. He initially manifested with gastrointestinal manifestations along with tachycardia. The patient was treated with fluid resuscitation, antidote-Dimercaprol, dialysis, and other supportive treatment. The patient continued to deteriorate with deranged liver and renal function, coagulopathy, and neurological symptoms. The presence of coagulopathy further complicated the scenario, as the antidote which is administered as an intramuscular injection could not be given. The patient continued to deteriorate and eventually succumbed. Acute arsenic poisoning is very rare, and very few reports of suicide are reported. It initially presents with acute gastroenteritis symptoms followed by multi organ involvement. Fatal doses will invariably result in death irrespective of treatment modality. Rapid administration of antidote and supportive treatment might increase the chances of survival. Difficulty in the availability of oral antidote and unavailability of any Intravenous preparations further complicates the scenario.
砷是地壳中自然存在的元素。慢性砷中毒已定期报道,主要是由于职业暴露在文献中。急性砷中毒非常罕见。一名27岁的绅士被送往医院,他曾试图通过服用三氧化二砷稀释水来自杀。他最初表现为胃肠道症状并伴有心动过速。患者给予液体复苏、解毒剂-二巯基丙醇、透析及其他支持治疗。患者病情持续恶化,肝肾功能紊乱,凝血功能障碍,神经系统症状。凝血功能障碍的存在使情况进一步复杂化,因为解毒剂不能以肌肉注射的方式给予。病人病情持续恶化,最终死亡。急性砷中毒非常罕见,也很少有自杀的报道。它最初表现为急性胃肠炎症状,随后多器官受累。不论采用何种治疗方式,致命剂量总是会导致死亡。迅速给予解毒剂和支持治疗可能会增加生存的机会。难以获得口服解毒剂和无法获得任何静脉注射制剂使情况进一步复杂化。
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引用次数: 1
The COVID Vaccine: is it the Beginning of the End? COVID - 19疫苗:是终结的开始吗?
Pub Date : 2021-01-29 DOI: 10.18311/IJMDS/2021/26800
G. Sidhu, Rakesh Kumar
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引用次数: 1
Periodontist an Asset to Systemic Diagnosis — Diagnosing a Case of Acute Myeloid Leukaemia 牙周病医生是系统诊断的资产-诊断一例急性髓性白血病
Pub Date : 2021-01-29 DOI: 10.18311/IJMDS/2021/26282
Somnath Pralhad Pachrupe, M. Phadnaik, Pooja Gupta
Acute Myeloid Leukemia (AML) is a neoplastic disease of bone marrow. AML M3 variant frequently develops swiftly and if not intervened immediately may prove fatal. This report presents a 32-year-old female who reported to dental OPD with complaint of bleeding gums and no previous medical history. On examination suspicious lesions were seen and patients was advised for full blood workup and Peripheral Blood Smear (PBS) investigations which revealed features suggestive of AML M3. The significant findings of this case are just presentation of oral manifestations, quick progression from initial symptoms to end stage and mild increase in WBC count which is uncommon for AML M3 variant. For many types of cancer, finding it early might make it uncomplicated to treat. This report outlines how a periodontist proved to be an asset in diagnosing a case of AML.
急性髓性白血病(AML)是一种骨髓肿瘤疾病。AML M3变异往往发展迅速,如果不立即干预可能是致命的。本文报告了一位32岁的女性,她到牙科门诊就诊,主诉牙龈出血,无既往病史。在检查中发现可疑病变,建议患者进行全血检查和外周血涂片(PBS)检查,显示提示AML M3的特征。该病例的重要发现仅为口腔表现,从最初症状到终末期进展迅速,白细胞计数轻度增加,这在AML M3变体中并不常见。对于许多类型的癌症,早期发现可能会使其治疗变得简单。本报告概述了如何证明牙周病医生是诊断AML病例的资产。
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引用次数: 0
Mycological Profile and Prevalence of Superficial Mycoses Agents: A Study from North India 印度北部浅表真菌病病原的真菌学特征和流行病学研究
Pub Date : 2021-01-29 DOI: 10.18311/IJMDS/2021/25828
S. Tyagi, R. Kaur, D. Rawat
Background: Superficial fungal infections are one of the commonest human infections. Causative agents of such infections may vary from yeasts like Candida species , Trichosporon species to dermatophytes and non-dermatophyte moulds. Fungal culture therefore, holds importance in identification and characterization of a fungal isolate, so that proper diagnosis can be made and correct treatment is instituted. Our objective was to study the etiology of the superficial fungal infections in patients presenting to the dermatology department in a tertiary care hospital in New Delhi. Materials and Methods: A total of 340 skin and hair samples from patients clinically suspected to have superficial fungal infection of skin and hair were microscopically examined and cultured over a period of 2 years. The percentage and frequency distribution of etiological fungal agents was studied. Also the performance of the culture and microscopy as methods of detecting fungal agents was statistically compared using Kappa and proportions of positive and negative agreement as well as McNemar’s Chi-squared value. Corresponding p-values were also calculated for both kappa and Chi-squared values. The analysis has been done using Epitools. Results: Of these, 57.6% were positive for fungal elements by microscopic examination and the overall positivity of fungal infection was 70%. Out of 238 culture positive samples, 72.7% grew dermatophytes and 27.3% grew non-dermatophytes (including 16.8% yeasts and 10.9% non-dermatophyte moulds. commonest (60.7%)
背景:浅表真菌感染是人类最常见的感染之一。这些感染的病原体可能从酵母菌,如念珠菌,毛孢菌到皮肤真菌和非皮肤真菌霉菌等多种多样。因此,真菌培养在鉴定和鉴定真菌分离物方面具有重要意义,因此可以做出正确的诊断并制定正确的治疗方法。我们的目的是研究在新德里一家三级护理医院皮肤科就诊的患者的浅表真菌感染的病因。材料与方法:对临床怀疑皮肤、毛发浅表真菌感染的患者340例皮肤、毛发标本进行了2年的显微镜检查和培养。对病原菌的百分比和频率分布进行了研究。此外,利用Kappa法、阳性和阴性一致性比例以及McNemar的卡方值对培养和显微镜作为真菌制剂检测方法的性能进行了统计比较。kappa值和卡方值也计算了相应的p值。分析是用Epitools完成的。结果:真菌镜检阳性率为57.6%,真菌感染阳性率为70%。238份培养阳性样本中,72.7%生长皮肤真菌,27.3%生长非皮肤真菌(包括16.8%的酵母和10.9%的非皮肤真菌霉菌)。常见(60.7%)
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引用次数: 1
Surgical Management of Zygomatico-Maxillary Complex Fractures with Two Point Fixation- A Clinical Case Presentation & Review of Literature 颧骨-上颌复合体骨折两点固定的手术治疗- 1例临床报告及文献复习
Pub Date : 2020-07-30 DOI: 10.18311/ijmds/2020/25050
M. Gawande, Supriya Dombre, Aamir Bidiwala, Tejasvini Dehankar
Assistant Professor, Department of Oral & Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur – 440016, India; drmayurgawande@gmail.com Senior Resident, Department of Oral & Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur – 440016, India Junior Resident, Department of Oral & Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur – 440016, India
Swargiya Dadasaheb Kalmegh Smruti牙科学院及医院口腔颌面外科助理教授,印度那格浦尔- 440016;drmayurgawande@gmail.com印度那格浦尔- 440016斯瓦吉雅达达萨heb Kalmegh Smruti牙科学院和医院口腔颌面外科高级住院医师,印度那格浦尔- 440016斯瓦吉雅达达萨heb Kalmegh Smruti牙科学院和医院口腔颌面外科初级住院医师
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引用次数: 1
Oxaceprol Monotherapy versus Oxaceprol and Glucosamine Combination Therapy for Knee Osteoarthritis 草乙酰丙醇单药治疗与草乙酰丙醇与氨基葡萄糖联合治疗膝关节骨关节炎
Pub Date : 2020-07-30 DOI: 10.18311/ijmds/2020/24871
Vijay Kumar, Sanjeev Sareen, Shreya Bhatia
Introduction: Osteoarthritis (OA) is the commonest form of arthritis which presents with joint pain and functional limitations. Oxaceprol, a derivative of hydroxyproline, inhibits leukocyte migration into the joints thus inhibiting inflammatory process. Oxaceprol also increases availability of Glucosamine and improving uptake of Glucosamine and Proline in chondrocytes. Aims and Objective: To demonstrate efficacy of Oxaceprol Monotherapy versus Oxaceprol and Glucosamine combination therapy in patients diagnosed with Knee Osteoarthritis (KOA). Materials and Methods: This was an open labelled, parallel group, Randomized Controlled Trial where 40 adults age ≥50 years diagnosed with KOA randomly received either Oxaceprol 600mg OD for 4 weeks, or combination of Oxaceprol 600mg OD and Glucosamine Sulphate 1500mg OD for 4 weeks. The patients were analysed as per the differences between WOMAC scale scores, and visual analogue scale (VAS) recording from baseline to 4 weeks of treatment. Results: Our study showed that both Oxaceprol monotherapy (group A, n=20), and Glucosamine plus Oxaceprol combination therapy (group B, n=20) improved joint pain, stiffness, and functionality as shown by analysing WOMAC scores before, and after 4 weeks of treatment. Interestingly, VAS scores, though improved in both the groups individually, were not significantly different from each other. Conclusion: Regardless of limitations, we conclude that the efficacy of Oxaceprol and Glucosamine combination therapy is better than Oxaceprol monotherapy. Further studies are required to examine mechanism of this effect at cellular level. Original Article
骨关节炎(OA)是最常见的关节炎形式,表现为关节疼痛和功能限制。氧乙酰丙醇是羟脯氨酸的衍生物,可抑制白细胞向关节的迁移,从而抑制炎症过程。草乙酰丙醇还能增加氨基葡萄糖的可用性,改善软骨细胞对氨基葡萄糖和脯氨酸的吸收。目的和目的:比较牛乙酰丙醇单药治疗与牛乙酰丙醇与氨基葡萄糖联合治疗对膝骨关节炎(KOA)患者的疗效。材料和方法:这是一项开放标记,平行组,随机对照试验,40名年龄≥50岁的诊断为KOA的成年人随机接受Oxaceprol 600mg OD的治疗4周,或Oxaceprol 600mg OD和Glucosamine sulfate 1500mg OD的联合治疗4周。根据WOMAC评分与视觉模拟评分(VAS)记录的基线至治疗4周的差异进行分析。结果:我们的研究表明,通过分析治疗前和治疗后4周的WOMAC评分,Oxaceprol单药治疗(A组,n=20)和葡萄糖胺加Oxaceprol联合治疗(B组,n=20)均能改善关节疼痛、僵硬和功能。有趣的是,尽管两组的VAS评分都有所提高,但彼此之间并没有显著差异。结论:不考虑局限性,我们认为草乙酰丙醇与氨基葡萄糖联合治疗的疗效优于草乙酰丙醇单药治疗。需要进一步的研究来检验这种作用在细胞水平上的机制。原文
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引用次数: 0
Endoscopic Assisted Styloidectomy - Indigenous Approach 内窥镜辅助茎突切除术-本地入路
Pub Date : 2020-07-21 DOI: 10.18311/ijmds/2020/25052
M. Munjal, J. Kaur, Porshia Rishi, Venus Tilavat, Shubham Munjal, Arush Singla
An individual with vague pain in the upper neck, after being treated with multitude of therapies, allopathy and alternative medicine, most likely is a victim of the “Eagle’s syndrome”. An endoscopic assisted surgical intervention provides relief and solace to many.
一个人在接受了多种疗法、对抗疗法和替代医学治疗后,颈部隐隐疼痛,很可能是“鹰氏综合症”的受害者。内窥镜辅助手术干预为许多人提供了缓解和安慰。
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引用次数: 0
The Hidden Face of Quarantine 隔离的隐藏面目
Pub Date : 2020-07-21 DOI: 10.18311/ijmds/2020/25699
G. Gulbahar, S. Sidhu
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引用次数: 0
A Study on Mycological Profile of Superficial Mycoses in a Rural Tertiary Care Hospital of Eastern India 印度东部农村三级医院浅表真菌病真菌学研究
Pub Date : 2020-07-21 DOI: 10.18311/ijmds/2020/24993
T. Biswas, S. Chattopadhyay, Raston Mondal
Background: Superficial mycosis is a very common fungal infection worldwide of the skin, hair and nails by dermatophytes, non dermatophytes and yeasts. Though they do not cause mortality, but are important agents causing morbidity, cosmetic disfigurement and recurrence leading to a major public health problem. Aim: Determine the clinico-mycological correlation and prevalence of dermatophytosis. Material and Methods: A six months observational cross sectional study was conducted from July 2019-December 2019 on 156 clinically diagnosed cases of superficial mycosis with no systemic complaints. Specimens were examined macroscopically as well as microscopically by KOH and culture. Result: Dermatophytosis was more in the males <40 years. KOH positivity was 100% and dermatophytes were the commonest superficial fungal infection 101/156 (64.74%), followed by Candidiasis 36/156 (23.08%). Non dermatophyte moulds in 06/156 (3.85%) and Malassezia furfur in 13/156 (8.33%) cases. Trichophyton was the commonest dermatophyte isolated (52.47%). Conclusions: Non-dermatophytic fungi are emerging as an important cause of superficial mycoses.
背景:浅表真菌病是一种在世界范围内由皮肤真菌、非皮肤真菌和酵母菌引起的非常常见的皮肤、头发和指甲真菌感染。虽然它们不会导致死亡,但它们是导致发病率、美容毁容和复发的重要因素,导致一个重大的公共卫生问题。目的:确定皮肤真菌病的临床-真菌学相关性和患病率。材料与方法:2019年7月- 2019年12月,对156例临床诊断无全身性症状的浅表性真菌病患者进行了为期6个月的观察性横断面研究。通过KOH和培养对标本进行宏观和微观检查。结果:40岁以下男性多见。KOH阳性100%,最常见的是皮肤真菌感染101/156(64.74%),其次是念珠菌感染36/156(23.08%)。非皮肤真菌06/156例(3.85%),马拉色菌13/156例(8.33%)。毛癣菌是最常见的皮肤真菌(52.47%)。结论:非皮肤真菌正在成为浅表真菌病的重要病因。
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引用次数: 2
期刊
International Journal of Medical and Dental Sciences
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