{"title":"The Wider Meaning of Addiction","authors":"G. Sidhu","doi":"10.18311/ijmds/2023/649","DOIUrl":"https://doi.org/10.18311/ijmds/2023/649","url":null,"abstract":"No Abstract.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84260735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Mahdani, Ulyasari Rachmaningayu, Elva Anjani, Asri Dewanti Adhi Nugrahaeni, Naqiya Ayunnisa, S. Putri, Meircurius Dwi Condro Surboyo, N. Ayuningtyas, Priyo Hadi, Hening Tuti Hendarti, D. Ernawati
Introduction: Citrus limon peels essential oil has the potential to be developed as a topical medicine due to its active components. The essential oil has been demonstrated in numerous studies to have anti-inflammatory, anti-microbial, antifungal, and antioxidant properties. A study is required to determine whether Citrus limon peel essential oil can cause a type IV hypersensitivity reaction by examining the expression of the cytokines TNF-, IL-1, and IL-6 as well as the clinical manifestations on an animal skin. In this study, the effect of topically applying the essential oil of Citrus limon peel on the expression of TNF-α, IL-1, and IL-6 as well as on type IV hypersensitivity reaction symptoms was examined. Methods: This study is based on the guinea-pig maximisation test method in NADFC RI Regulation Number 7 of 2014, with two groups (control group and treatment group) for each set of ten samples. Citrus limon peels essential oil was administered to the treatment group, whereas CMC-Na was given to the control group. Animal models were euthanized after which the tissues were prepared as specimens for immunohistochemical staining. The expression of cytokines was computed and examined using a light microscope. Results: There were no clinical signs of type IV hypersensitivity in either group, and the expression of TNF-α, IL-1 and IL-6 in the treatment group was found higher than in the control group. Conclusion: After topical administration of Citrus limon peels essential oil, there was an increase in the expression of TNF-α, IL-1 and IL-6 without any clinical symptoms of type IV hypersensitivity.
{"title":"Topical Application of Citrus limon Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction","authors":"F. Mahdani, Ulyasari Rachmaningayu, Elva Anjani, Asri Dewanti Adhi Nugrahaeni, Naqiya Ayunnisa, S. Putri, Meircurius Dwi Condro Surboyo, N. Ayuningtyas, Priyo Hadi, Hening Tuti Hendarti, D. Ernawati","doi":"10.18311/ijmds/2023/645","DOIUrl":"https://doi.org/10.18311/ijmds/2023/645","url":null,"abstract":"Introduction: Citrus limon peels essential oil has the potential to be developed as a topical medicine due to its active components. The essential oil has been demonstrated in numerous studies to have anti-inflammatory, anti-microbial, antifungal, and antioxidant properties. A study is required to determine whether Citrus limon peel essential oil can cause a type IV hypersensitivity reaction by examining the expression of the cytokines TNF-, IL-1, and IL-6 as well as the clinical manifestations on an animal skin. In this study, the effect of topically applying the essential oil of Citrus limon peel on the expression of TNF-α, IL-1, and IL-6 as well as on type IV hypersensitivity reaction symptoms was examined. Methods: This study is based on the guinea-pig maximisation test method in NADFC RI Regulation Number 7 of 2014, with two groups (control group and treatment group) for each set of ten samples. Citrus limon peels essential oil was administered to the treatment group, whereas CMC-Na was given to the control group. Animal models were euthanized after which the tissues were prepared as specimens for immunohistochemical staining. The expression of cytokines was computed and examined using a light microscope. Results: There were no clinical signs of type IV hypersensitivity in either group, and the expression of TNF-α, IL-1 and IL-6 in the treatment group was found higher than in the control group. Conclusion: After topical administration of Citrus limon peels essential oil, there was an increase in the expression of TNF-α, IL-1 and IL-6 without any clinical symptoms of type IV hypersensitivity.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81787959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Intraoral Scanners (IOS) are devices which are used for capturing direct optical impressions in dentistry. They are handheld devices used to directly create digital impression data of the oral cavity. Light source from the scanner is projected onto the scan objects, such as full dental arches, and then a 3D model processed by the scanning software will be displayed in real-time on a touch screen. Pediatric dental patients requiring dental prostheses is considered the most challenging for dental professionals owing to managing the children’s behavioural problems, gagging reflex, foreign body aspiration, and choking (breathing) concerns. The conventional impression-making procedures in young children are regarded as quite cumbersome and difficult due to several clinical factors in dentistry. Pediatric dentistry is evolving to minimise the disadvantages of traditional techniques by introducing advanced digital intraoral scanners in the field of pediatric dentistry. Thus this paper reviews the application of intraoral scanners in pediatric dentistry.
{"title":"Role of Intraoral Scanners in Pediatric Dentistry","authors":"Mahima Panwar, Sonal Gupta, Utkarsh Singh, Asmita Das, Simran Isha","doi":"10.18311/ijmds/2023/646","DOIUrl":"https://doi.org/10.18311/ijmds/2023/646","url":null,"abstract":"Intraoral Scanners (IOS) are devices which are used for capturing direct optical impressions in dentistry. They are handheld devices used to directly create digital impression data of the oral cavity. Light source from the scanner is projected onto the scan objects, such as full dental arches, and then a 3D model processed by the scanning software will be displayed in real-time on a touch screen. Pediatric dental patients requiring dental prostheses is considered the most challenging for dental professionals owing to managing the children’s behavioural problems, gagging reflex, foreign body aspiration, and choking (breathing) concerns. The conventional impression-making procedures in young children are regarded as quite cumbersome and difficult due to several clinical factors in dentistry. Pediatric dentistry is evolving to minimise the disadvantages of traditional techniques by introducing advanced digital intraoral scanners in the field of pediatric dentistry. Thus this paper reviews the application of intraoral scanners in pediatric dentistry.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83975881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Biodentin is a pulp capping material that has perfected the shortcomings of Ca(OH)2, but has low radiopacity and lower washing out resistance, so it is hoped that there will be natural ingredients that can be used as pulp capping materials. The nano brown anchovy has antibacterial content in the form of fluoride. Its nano size can also facilitate penetration better. Purpose: Analyzing the antibacterial potency of nano brown anchovy on mixed bacteria in deep carious dentine. Methods: The research was conducted in an experimental laboratory in vitro with a post-test only control group design. Brown anchovy was converted into nanoparticles then diluted into several concentrations using the broth dilution method. Direct contact method was used between nano anchovy and various concentrations of bacteria. The values of MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bacterial Concentration) were obtained by counting the number of bacterial colonies growing on Mueller Hinton Agar media. Colony growth was calculated manually in Colony Forming Units (CFU). Data were analysed by One Way Anova test followed by a Tukey HSD test. Results: The MIC value at a concentration of 0.781% and the MBC value at a concentration of 1.56%. In positive control, there was an average bacterial death of 0%, a concentration of 0.781% had an average bacterial death of 91%, and at a concentration of 1.56% the average bacterial death was 100%. The results showed that the greater the concentration of nano anchovy, the stronger the antibacterial power. Conclusion: There is antibacterial potency in nano brown anchovy against Mixed Bacteria in deep dentin caries lesions.
{"title":"Antibacterial Power of Nano Brown Anchovy (Stolephorus insularis) Against Mixed Bacteria in Deep Dentin Caries","authors":"Tamara Yuanita, Shafa Marwa, Moza Paramitha, Arinda Sitania Mustamu","doi":"10.18311/ijmds/2023/621","DOIUrl":"https://doi.org/10.18311/ijmds/2023/621","url":null,"abstract":"Background: Biodentin is a pulp capping material that has perfected the shortcomings of Ca(OH)2, but has low radiopacity and lower washing out resistance, so it is hoped that there will be natural ingredients that can be used as pulp capping materials. The nano brown anchovy has antibacterial content in the form of fluoride. Its nano size can also facilitate penetration better. Purpose: Analyzing the antibacterial potency of nano brown anchovy on mixed bacteria in deep carious dentine. Methods: The research was conducted in an experimental laboratory in vitro with a post-test only control group design. Brown anchovy was converted into nanoparticles then diluted into several concentrations using the broth dilution method. Direct contact method was used between nano anchovy and various concentrations of bacteria. The values of MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bacterial Concentration) were obtained by counting the number of bacterial colonies growing on Mueller Hinton Agar media. Colony growth was calculated manually in Colony Forming Units (CFU). Data were analysed by One Way Anova test followed by a Tukey HSD test. Results: The MIC value at a concentration of 0.781% and the MBC value at a concentration of 1.56%. In positive control, there was an average bacterial death of 0%, a concentration of 0.781% had an average bacterial death of 91%, and at a concentration of 1.56% the average bacterial death was 100%. The results showed that the greater the concentration of nano anchovy, the stronger the antibacterial power. Conclusion: There is antibacterial potency in nano brown anchovy against Mixed Bacteria in deep dentin caries lesions.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82479740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scientific Integrity-Overcoming Challenges in Medical Research and Publication","authors":"J. Mahendra","doi":"10.18311/ijmds/2022/635","DOIUrl":"https://doi.org/10.18311/ijmds/2022/635","url":null,"abstract":"No Abstract.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73288158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The War on Drugs: A Global Perspective","authors":"G. Sidhu","doi":"10.18311/ijmds/2022/638","DOIUrl":"https://doi.org/10.18311/ijmds/2022/638","url":null,"abstract":"No Abstract.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86826010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist has recently been approved by FDA for type 2 diabetes in adults as a single dose weekly. Tirzepatide is in phase 3 development for adults with obesity or overweight with weight-related comorbidity. Tirzepatide is also under evaluation for treatment of non-alcoholic steatohepatitis, heart faialure and obstructive sleep apnea.
{"title":"Tirzepatide: Revolutionary Drug in Management of “Diabesity”","authors":"Vansh Chouhan, Simran Spal, Rakesh Kumar","doi":"10.18311/ijmds/2022/636","DOIUrl":"https://doi.org/10.18311/ijmds/2022/636","url":null,"abstract":"Tirzepatide, a glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonist has recently been approved by FDA for type 2 diabetes in adults as a single dose weekly. Tirzepatide is in phase 3 development for adults with obesity or overweight with weight-related comorbidity. Tirzepatide is also under evaluation for treatment of non-alcoholic steatohepatitis, heart faialure and obstructive sleep apnea.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77910691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Severe Acute Respiratory syndrome Coronavirus–2 (SARS –Cov-2) named COVID-19 (Coronavirus Disease – 2019) pandemic is the biggest public health problem the human mankind is facing today. Objective: Primary objective was to determine in-hospital mortality within 30 days of admission. The secondary objective was to analyze the risk factors leading to deterioration and poor outcome in patients suffering from COVID-19 infections. Material and Methods: This Multicentric, Retrospective Observational cohort study was conducted in confirmed COVID-19 infected patients admitted in three COVID care centers of Jalandhar city during January 2020 to June 2021. The data of admitted Patients was retrospectively analyzed. The study has been approved by Institutional Ethics Committee of Punjab Institute of Medical Sciences, Jalandhar reference number PIMS/IEC/22/10. Results: Total 1139 patients were admitted in three COVID centers of the city during the period of January 2020 to June 2021. The mean age of the patients was 54.96 ±15.43, 706 (62%) were male and 433 (38%) were female, 523 (45.9%) belong to rural area and 616 (54.1%) belong to urban area. 580 (50.9%) have comorbid condition while 559 (49.1%) do not have any comorbidity. The total number of deaths reported was 225 (19.8%). Comorbidities were seen in 580 patients (50.9%) with 126 deaths (21.7%). Out of 1139, 336(29.5%), 211(18.5%), 31(2.7%), 2(0.2%) had one, two, three and four number of comorbidities respectively. The maximum number of deaths i.e. 140 deaths (12.3%) were seen in the age group of 51–75. Conclusion: Maximum mortality rate was seen in the age group of 50-75 years of age, with significant number of deaths in rural population with two comorbidities in patients suffering from Diabetes and hypertension.
{"title":"Evaluation of Outcome In Patients Suffering from COVID-19 Infection – A Retrospective Study","authors":"Tanveer Singh, Navjot Singh Dahiya, Angad Singh Johal, Jasmine Kaur","doi":"10.18311/ijmds/2022/583","DOIUrl":"https://doi.org/10.18311/ijmds/2022/583","url":null,"abstract":"Background: Severe Acute Respiratory syndrome Coronavirus–2 (SARS –Cov-2) named COVID-19 (Coronavirus Disease – 2019) pandemic is the biggest public health problem the human mankind is facing today. Objective: Primary objective was to determine in-hospital mortality within 30 days of admission. The secondary objective was to analyze the risk factors leading to deterioration and poor outcome in patients suffering from COVID-19 infections. Material and Methods: This Multicentric, Retrospective Observational cohort study was conducted in confirmed COVID-19 infected patients admitted in three COVID care centers of Jalandhar city during January 2020 to June 2021. The data of admitted Patients was retrospectively analyzed. The study has been approved by Institutional Ethics Committee of Punjab Institute of Medical Sciences, Jalandhar reference number PIMS/IEC/22/10. Results: Total 1139 patients were admitted in three COVID centers of the city during the period of January 2020 to June 2021. The mean age of the patients was 54.96 ±15.43, 706 (62%) were male and 433 (38%) were female, 523 (45.9%) belong to rural area and 616 (54.1%) belong to urban area. 580 (50.9%) have comorbid condition while 559 (49.1%) do not have any comorbidity. The total number of deaths reported was 225 (19.8%). Comorbidities were seen in 580 patients (50.9%) with 126 deaths (21.7%). Out of 1139, 336(29.5%), 211(18.5%), 31(2.7%), 2(0.2%) had one, two, three and four number of comorbidities respectively. The maximum number of deaths i.e. 140 deaths (12.3%) were seen in the age group of 51–75. Conclusion: Maximum mortality rate was seen in the age group of 50-75 years of age, with significant number of deaths in rural population with two comorbidities in patients suffering from Diabetes and hypertension.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84850844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Mobile Colon is a subtle developmental anomaly, which is due to the failure of the process of peritoneal zygosis. The incidence of this anomaly is estimated to be 10-15% of the population. Evidence Acquisition: During routine cadaveric dissection of the abdomen in the Department of Anatomy, collective anomalies of the caecum, ascending colon and descending colon were found. In these collective anomalies cecum, ascending and descending colon instead of normally being retroperitoneal were suspended from the posterior abdominal wall by a fold of peritoneum called the mesentery. Mobile colon is an uncommon anomaly, which is being reported here. Clinical Implications: Mobile colon is usually asymptomatic but whenever it becomes symptomatic, it leads to mobile colon syndrome. Clinical symptoms associated with mobile colon syndrome mimic other common gastrointestinal disorders such as inflammatory bowel disease, malignancy, appendicitis and volvulus. Complications of this syndrome include intestinal obstruction, torsion of the intestine and gangrenous bowel which needs immediate treatment. Conclusion: Mobile colon syndrome should be considered in the differential diagnosis of chronic abdominal pain of obscure cause. Laparoscopic colopexy and cecopexy are recommended as therapeutic and diagnostic treatments.
{"title":"Mobile Colon – A Developmental Anomaly of the Large Intestine","authors":"Anuradha Dehiya, Ravikant Sharma, Sehajdeep Kaur","doi":"10.18311/ijmds/2022/629","DOIUrl":"https://doi.org/10.18311/ijmds/2022/629","url":null,"abstract":"Introduction: Mobile Colon is a subtle developmental anomaly, which is due to the failure of the process of peritoneal zygosis. The incidence of this anomaly is estimated to be 10-15% of the population. Evidence Acquisition: During routine cadaveric dissection of the abdomen in the Department of Anatomy, collective anomalies of the caecum, ascending colon and descending colon were found. In these collective anomalies cecum, ascending and descending colon instead of normally being retroperitoneal were suspended from the posterior abdominal wall by a fold of peritoneum called the mesentery. Mobile colon is an uncommon anomaly, which is being reported here. Clinical Implications: Mobile colon is usually asymptomatic but whenever it becomes symptomatic, it leads to mobile colon syndrome. Clinical symptoms associated with mobile colon syndrome mimic other common gastrointestinal disorders such as inflammatory bowel disease, malignancy, appendicitis and volvulus. Complications of this syndrome include intestinal obstruction, torsion of the intestine and gangrenous bowel which needs immediate treatment. Conclusion: Mobile colon syndrome should be considered in the differential diagnosis of chronic abdominal pain of obscure cause. Laparoscopic colopexy and cecopexy are recommended as therapeutic and diagnostic treatments.","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74782886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-16DOI: 10.18311/ijmds/2021/28196
Gurbilas P. Singh
{"title":"Caring for non-Covid Patients – are we Pandemic Ready","authors":"Gurbilas P. Singh","doi":"10.18311/ijmds/2021/28196","DOIUrl":"https://doi.org/10.18311/ijmds/2021/28196","url":null,"abstract":"<jats:p />","PeriodicalId":14010,"journal":{"name":"International Journal of Medical and Dental Sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80756994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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