Pub Date : 2023-09-01DOI: 10.21276/ssr-iijls.2023.9.5.6
Anuradha G Melligeri, Deelip S Natekar, Ameenuddin Naik, Asma Kandagal, Pundaleek Hucchellapagoa, Savitha hosamani, Saraswathi K
Background: India has been known as a house for people with non-communicable diseases. According to World Health Organization, diabetes cases are increasing rapidly in India, with an estimated 8.7% diabetic population in the age group of 20 and 70 years. Stress and Hyperglycaemia complement each other, ultimately hindering the Quality of life of a person. The study aimed to assess and compare the stress level and quality of life among Type 1 and Type 2 Diabetic Mellitus patients. Methods: The data was collected from 100 diabetic patients (50 type 1 & 50 type 2). By using Convenient sampling technique data was selected. Stress Scale was used to assess the level of stress & WHO Bref-26 Quality of Life Scale was used to assess quality of life. The comparison of stress and quality of life was done using the ‘t’ test and the association was determined using the Chi-square test. Results: 70% of patients with diabetic mellitus (DM) Type 1 had high level of stress, 20% had moderate and 10% had low level of stress. In type II DM patients, 92% had moderate stress levels and 8% had low stress level. Negative correlation between stress and quality of life among type 1 and type 2 diabetic mellitus patients. Conclusion: A statistically negative correlation exists between stress and quality of life among type 1 and Type 2 patients.
{"title":"Comparative study Assess the Level of Stress and Quality of Life among Type 1 and Type 2 Diabetic Mellitus Patients at Bagalkot","authors":"Anuradha G Melligeri, Deelip S Natekar, Ameenuddin Naik, Asma Kandagal, Pundaleek Hucchellapagoa, Savitha hosamani, Saraswathi K","doi":"10.21276/ssr-iijls.2023.9.5.6","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.6","url":null,"abstract":"Background: India has been known as a house for people with non-communicable diseases. According to World Health Organization, diabetes cases are increasing rapidly in India, with an estimated 8.7% diabetic population in the age group of 20 and 70 years. Stress and Hyperglycaemia complement each other, ultimately hindering the Quality of life of a person. The study aimed to assess and compare the stress level and quality of life among Type 1 and Type 2 Diabetic Mellitus patients. Methods: The data was collected from 100 diabetic patients (50 type 1 & 50 type 2). By using Convenient sampling technique data was selected. Stress Scale was used to assess the level of stress & WHO Bref-26 Quality of Life Scale was used to assess quality of life. The comparison of stress and quality of life was done using the ‘t’ test and the association was determined using the Chi-square test. Results: 70% of patients with diabetic mellitus (DM) Type 1 had high level of stress, 20% had moderate and 10% had low level of stress. In type II DM patients, 92% had moderate stress levels and 8% had low stress level. Negative correlation between stress and quality of life among type 1 and type 2 diabetic mellitus patients. Conclusion: A statistically negative correlation exists between stress and quality of life among type 1 and Type 2 patients.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Morphometric analysis has been very popular among researchers. In the medical field, morphometric studies have produced significant results in personal identification, differentiating the populations of various races and ethnic backgrounds. This study was intended to evaluate the dimensions of frontal sinus cavities to observe the patterns of frontal sinus & nasal septum. Find out if there is any association between the frontal sinus and nasal septum parameters and their implications in personal identification. Methods: The data used in the study had to be collected from the archival records of digital X-rays so the study was based on a retrospective study design. Two hundred digital radiographic films were collected from both regions, consisting of 100 males and 100 females. The frontal sinus parameters were used to define the pattern for the nasal septum. Five main patterns were recorded. Data was statistically analyzed and descriptive stats, associations and inferences were generated. Results: The results revealed that 69% of males and 66% of females had a symmetrical pattern of frontal sinus. Combined use of FSP and NSP revealed interesting results. Conclusion: The frontal sinus can be used as an adjunct to other firm criteria instead of solely dependent on frontal and nasal sinus septum. However, it can be used to identify the ethnic background of a race.
{"title":"Radiographic Study of Frontal Sinus Patterns and Nasal Septum Patterns Emphasizing their Implication in Personal Identification","authors":"Pinki Rai, Amit Kumar Saxena, Ashima Das, Bhamini Sharma, Jashanpreet Kaur","doi":"10.21276/ssr-iijls.2023.9.5.5","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.5","url":null,"abstract":"Background: Morphometric analysis has been very popular among researchers. In the medical field, morphometric studies have produced significant results in personal identification, differentiating the populations of various races and ethnic backgrounds. This study was intended to evaluate the dimensions of frontal sinus cavities to observe the patterns of frontal sinus & nasal septum. Find out if there is any association between the frontal sinus and nasal septum parameters and their implications in personal identification. Methods: The data used in the study had to be collected from the archival records of digital X-rays so the study was based on a retrospective study design. Two hundred digital radiographic films were collected from both regions, consisting of 100 males and 100 females. The frontal sinus parameters were used to define the pattern for the nasal septum. Five main patterns were recorded. Data was statistically analyzed and descriptive stats, associations and inferences were generated. Results: The results revealed that 69% of males and 66% of females had a symmetrical pattern of frontal sinus. Combined use of FSP and NSP revealed interesting results. Conclusion: The frontal sinus can be used as an adjunct to other firm criteria instead of solely dependent on frontal and nasal sinus septum. However, it can be used to identify the ethnic background of a race.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21276/ssr-iijls.2023.9.5.2
Pooja Pandey Tripathi
{"title":"Effect of Combined Treatment of Massage, Exercise and KIASTM with That of Only Exercise in Patients with Diastasis Recti","authors":"Pooja Pandey Tripathi","doi":"10.21276/ssr-iijls.2023.9.5.2","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.2","url":null,"abstract":"","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21276/ssr-iijls.2023.9.5.7
Farhana Zerin
Background: The COVID-19 outbreak has impacted people's mental health, particularly in the workplace. Stress and depression were worsened by job insecurity, social isolation, and health worries. The Bangladeshi garment sector experienced a drop in demand due to the lockouts, leading to rising worker poverty levels. Mental anguish was enhanced as a result of both the delay in wage payments and safety violations. This study evaluated the psychological consequences experienced by Bangladeshi garment factory workers in the post-COVID-19 era. Method: With factory consent, a study assessed mental health among Bangladeshi garment workers from January 2023 to July 2023. Surveys gathered demographic data, medical history, depression, anxiety, stress, and posttraumatic stress disorder scores (DASS-21, IES-R). Insights on emotional well-being, work experiences, financial stress, and pandemic effects were explored. The comprehensive assessment encompassed multiple dimensions, including emotional, work-related, economic, social, and industry-specific. Inclusion criteria covered factory workers present during the study, while exclusion criteria considered chronic disorders and response consistency. Result: Regarding gender, 42% were males and 40% were females. Relationship statuses vary: married (26%), committed (34%), single (7%), divorced/separated (7%), and widowed (6%). Occupationally, managerial positions are 8%, supervisors 15%, clerical/administrative 20%, catering 3%, security 5%, and factory laborers 31%. COVID-19 interactions: 42% yes, 40% no hemoglobin levels are detailed. In Table 2, the DASS-21 and IES-R scores are compared. Gender differences showed higher depression and anxiety in females (p<0.05). Conclusion: The study concluded that there was clinically significant depression and anxiety in female workers.
{"title":"Post-COVID Psychological Impact on Bangladeshi Garment Industry Workers","authors":"Farhana Zerin","doi":"10.21276/ssr-iijls.2023.9.5.7","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.7","url":null,"abstract":"Background: The COVID-19 outbreak has impacted people's mental health, particularly in the workplace. Stress and depression were worsened by job insecurity, social isolation, and health worries. The Bangladeshi garment sector experienced a drop in demand due to the lockouts, leading to rising worker poverty levels. Mental anguish was enhanced as a result of both the delay in wage payments and safety violations. This study evaluated the psychological consequences experienced by Bangladeshi garment factory workers in the post-COVID-19 era. Method: With factory consent, a study assessed mental health among Bangladeshi garment workers from January 2023 to July 2023. Surveys gathered demographic data, medical history, depression, anxiety, stress, and posttraumatic stress disorder scores (DASS-21, IES-R). Insights on emotional well-being, work experiences, financial stress, and pandemic effects were explored. The comprehensive assessment encompassed multiple dimensions, including emotional, work-related, economic, social, and industry-specific. Inclusion criteria covered factory workers present during the study, while exclusion criteria considered chronic disorders and response consistency. Result: Regarding gender, 42% were males and 40% were females. Relationship statuses vary: married (26%), committed (34%), single (7%), divorced/separated (7%), and widowed (6%). Occupationally, managerial positions are 8%, supervisors 15%, clerical/administrative 20%, catering 3%, security 5%, and factory laborers 31%. COVID-19 interactions: 42% yes, 40% no hemoglobin levels are detailed. In Table 2, the DASS-21 and IES-R scores are compared. Gender differences showed higher depression and anxiety in females (p<0.05). Conclusion: The study concluded that there was clinically significant depression and anxiety in female workers.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21276/ssr-iijls.2023.9.5.1
Shridevi Teli, Deelip S Natekar, Pooja R Hanagandi, Sheebarani Ajagarani, Sachin Bellihal, Mallikarjun Tenginakayi, Rangappa Dinni, Sumitra Hakkal, Tulasappa Hosamani
Background: Stress has presented difficult issues for youngsters. It has an immediate bearing on their academic life. Children need good mental and physical well-being to act in their academic achievement more readily. Academic stress is a significant wellspring of stress among children and may affect children's self-esteem. Methods: A descriptive comparative research design was used for the study and was conducted on 100 students using a non-probability sampling technique from selected rural and urban school children. Data was collected by using Rosenberg's Self-esteem and Inventory version 4 academic stress scales. Results: The study shows 84% of urban children average self-esteem. 98% of rural children had average self-esteem. Also, a total 16% of urban children had high academic stress. But no rural children had high academic stress. The obtained r-value was (- 0.1125) and (-0.0177); hence, we found a negative correlation between academic stress and self-esteem among urban and rural children. There was a significant difference in academic stress and self-esteem among urban and rural children. Conclusion: The study concluded that there is a negative correlation between academic stress and self-esteem among urban and rural children. Comparison of academic stress and self-esteem among rural and urban children having a significant difference.
{"title":"Comparative Study to Assess the Academic Stress and Self Esteem among School Going Children of both Urban Rural Areas of Bagalkot","authors":"Shridevi Teli, Deelip S Natekar, Pooja R Hanagandi, Sheebarani Ajagarani, Sachin Bellihal, Mallikarjun Tenginakayi, Rangappa Dinni, Sumitra Hakkal, Tulasappa Hosamani","doi":"10.21276/ssr-iijls.2023.9.5.1","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.1","url":null,"abstract":"Background: Stress has presented difficult issues for youngsters. It has an immediate bearing on their academic life. Children need good mental and physical well-being to act in their academic achievement more readily. Academic stress is a significant wellspring of stress among children and may affect children's self-esteem. Methods: A descriptive comparative research design was used for the study and was conducted on 100 students using a non-probability sampling technique from selected rural and urban school children. Data was collected by using Rosenberg's Self-esteem and Inventory version 4 academic stress scales. Results: The study shows 84% of urban children average self-esteem. 98% of rural children had average self-esteem. Also, a total 16% of urban children had high academic stress. But no rural children had high academic stress. The obtained r-value was (- 0.1125) and (-0.0177); hence, we found a negative correlation between academic stress and self-esteem among urban and rural children. There was a significant difference in academic stress and self-esteem among urban and rural children. Conclusion: The study concluded that there is a negative correlation between academic stress and self-esteem among urban and rural children. Comparison of academic stress and self-esteem among rural and urban children having a significant difference.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21276/ssr-iijls.2023.9.5.3
Siddartha Gadagi, Shridhar Pujar, Deelip S. Natekar
Backgrounds: The skin is an active and largest organ in our body. The skin protects the storage of food, regulates temperature and a sense organ. The epidermis shields underlying tissue against water loss and injury and prevents entry of micro-organisms. The dermis continues with nerve fibres, sebaceous blood vessels, sweat glands, and hair follicle". The data was analyzed by using descriptive study; the sample includes 100 caregivers. Methods: Simple random technique was used to select the hospitals, and a convenient sampling technique was used to select the samples for the study. Data was collected using a structured knowledge questionnaire and self-constructed practice scale and analyzed using descriptive and inferential statistics. Results: The mean percentage of knowledge scores of pressure ulcers among caregivers of immobilized clients was 16.91% score and SD (3.59). The mean percentage of practice scores of pressure ulcers among caregivers of immobilized clients was 15.33% score SD (4.98). The 'r'-value is (-0.05); hence it is clear that there is a statistically negative co-relation between knowledge and practice of pressure ulcers among caregivers of immobilized clients. Conclusion: The study concluded no significant difference was found between the knowledge and practice scores of pressure ulcers among caregivers of immobilized clients. Negative correlation between knowledge and practice of pressure ulcers among caregivers of immobilized clients.
{"title":"Evaluation of Knowledge and Practice on Pressure Ulcer Prevention among Immobilized Clients at HSK Hospital","authors":"Siddartha Gadagi, Shridhar Pujar, Deelip S. Natekar","doi":"10.21276/ssr-iijls.2023.9.5.3","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.3","url":null,"abstract":"Backgrounds: The skin is an active and largest organ in our body. The skin protects the storage of food, regulates temperature and a sense organ. The epidermis shields underlying tissue against water loss and injury and prevents entry of micro-organisms. The dermis continues with nerve fibres, sebaceous blood vessels, sweat glands, and hair follicle\". The data was analyzed by using descriptive study; the sample includes 100 caregivers. Methods: Simple random technique was used to select the hospitals, and a convenient sampling technique was used to select the samples for the study. Data was collected using a structured knowledge questionnaire and self-constructed practice scale and analyzed using descriptive and inferential statistics. Results: The mean percentage of knowledge scores of pressure ulcers among caregivers of immobilized clients was 16.91% score and SD (3.59). The mean percentage of practice scores of pressure ulcers among caregivers of immobilized clients was 15.33% score SD (4.98). The 'r'-value is (-0.05); hence it is clear that there is a statistically negative co-relation between knowledge and practice of pressure ulcers among caregivers of immobilized clients. Conclusion: The study concluded no significant difference was found between the knowledge and practice scores of pressure ulcers among caregivers of immobilized clients. Negative correlation between knowledge and practice of pressure ulcers among caregivers of immobilized clients.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.21276/ssr-iijls.2023.9.5.4
Rajashekhargouda Hiregoudar, Dileep S. Natekar
{"title":"Comparative Study of Stress among Teachers Working in Government and Private High Schools of Vijayapura, Karnataka","authors":"Rajashekhargouda Hiregoudar, Dileep S. Natekar","doi":"10.21276/ssr-iijls.2023.9.5.4","DOIUrl":"https://doi.org/10.21276/ssr-iijls.2023.9.5.4","url":null,"abstract":"","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-30DOI: 10.20448/lifsc.v10i1.4954
Jin-hua Ouyang
The biological effects due to a hypomagnetic field (HMF) is a very important subject not only for aerospace traveling and space station living but also for some magnetic shielding conditions on the ground just like the underground bunkers and etc. However, to my knowledge, the mechanisms which can be related to the biological effects of a HMF remain unclear. In this study, I firstly summary one radical pair mechanism of biological effects on a HMF based on present researches, and then propose how to prove the radical pair mechanism’s truth in biological effects on a HMF through experiments. In the way of how to prove the radical pair mechanism’s truth I give the relation between the singlet yield of the radical pair and the angle describing the orientation of a HMF to the basis of the hyperfine tensor related to the electron spin and the nuclei spin is the possible one radical pair mechanism on one hand, and give the crucial method which is through that angle changed causes the biological effects in vivo or vitro to prove or disprove the mechanism on the other hand, because the biological effects of a HMF can be related with that angle, which is very easy to be controlled in experiments.
{"title":"The radical pair mechanism of biological effects on hypomagnetic fields and one method to verify it","authors":"Jin-hua Ouyang","doi":"10.20448/lifsc.v10i1.4954","DOIUrl":"https://doi.org/10.20448/lifsc.v10i1.4954","url":null,"abstract":"The biological effects due to a hypomagnetic field (HMF) is a very important subject not only for aerospace traveling and space station living but also for some magnetic shielding conditions on the ground just like the underground bunkers and etc. However, to my knowledge, the mechanisms which can be related to the biological effects of a HMF remain unclear. In this study, I firstly summary one radical pair mechanism of biological effects on a HMF based on present researches, and then propose how to prove the radical pair mechanism’s truth in biological effects on a HMF through experiments. In the way of how to prove the radical pair mechanism’s truth I give the relation between the singlet yield of the radical pair and the angle describing the orientation of a HMF to the basis of the hyperfine tensor related to the electron spin and the nuclei spin is the possible one radical pair mechanism on one hand, and give the crucial method which is through that angle changed causes the biological effects in vivo or vitro to prove or disprove the mechanism on the other hand, because the biological effects of a HMF can be related with that angle, which is very easy to be controlled in experiments.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136162399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-09DOI: 10.20448/lifsc.v9i1.3689
Pablo Morales-Carreno, R. Rodrigo
The most effective therapeutic intervention for reducing infarct size and improving outcomes in patients with acute myocardial infarction is the thrombolytic therapy or percutaneous coronary angioplasty. However, this process itself can generate ischemia-reperfusion injury that can be responsible for up to 50% of the final infarct size. Considering oxidative stress as the main damaging agent in this pathology, it has been postulated that reinforcing antioxidant defenses could improve cardiac function. However, up to date clinical trials based on monotherapies have been consistent in the favorable results. In this review the pathophysiological mechanisms of myocardial injury due to ischemia/reperfusion in patients undergoing percutaneous coronary angioplasty are updated. In addition, new therapeutic alternatives for cardioprotection in this population, are explored, with emphasis in the combined therapy as a novel antioxidant treatment for this myocardial injury.
{"title":"Role of Oxidative Stress as a Novel Therapeutic Target in Myocardial Injury Due to Ischemia/Reperfusion in Patients with Acute Myocardial Infarction","authors":"Pablo Morales-Carreno, R. Rodrigo","doi":"10.20448/lifsc.v9i1.3689","DOIUrl":"https://doi.org/10.20448/lifsc.v9i1.3689","url":null,"abstract":"The most effective therapeutic intervention for reducing infarct size and improving outcomes in patients with acute myocardial infarction is the thrombolytic therapy or percutaneous coronary angioplasty. However, this process itself can generate ischemia-reperfusion injury that can be responsible for up to 50% of the final infarct size. Considering oxidative stress as the main damaging agent in this pathology, it has been postulated that reinforcing antioxidant defenses could improve cardiac function. However, up to date clinical trials based on monotherapies have been consistent in the favorable results. In this review the pathophysiological mechanisms of myocardial injury due to ischemia/reperfusion in patients undergoing percutaneous coronary angioplasty are updated. In addition, new therapeutic alternatives for cardioprotection in this population, are explored, with emphasis in the combined therapy as a novel antioxidant treatment for this myocardial injury.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78214291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.20448/journal.504.2021.81.1.9
Zulfia Hussain, Haroon Rashid, Aqsa Mushtaq, R. Siddique, Ashiq Ali
Daily exposure to a number of xenobiotics is the major contributing factor to liver injury. The present study investigated the mechanism of hepatoprotection by glycyrrhizin, curcumin and cinnamon in two distinct models of hepatotoxicity i.e., by using Concanavalin-A (ConA) and Acetaminophen (APAP). For this evaluation, balb/c mice were pretreated with glycyrrhizin (200 mg/kg i.g.), curcumin (100 mg/kg i.g.) and cinnamon (200 mg/kg i.g.) extracts for 14 days followed by administration of ConA (15 mg/kg i.v.) and APAP (200 mg/kg i.p.) for 8 hours. At the end of the experiment, mice were dissected and blood and liver samples were collected for biochemical and histopathological analysis. Statistical analysis by using one-way ANOVA followed by DMR test was performed for the significance of results. The results showed that pre-treatment of glycyrrhizin, curcumin and cinnamon ameliorated the damaging effects of ConA and APAP on the liver as indicated by the serum transaminase enzymes and total protein levels. In addition, ConA and APAP exerted severe damage on liver tissues as confirmed from the histopathological analysis. However, glycyrrhizin, curcumin and cinnamon prevented liver injury, possibly through antioxidant mechanism. In conclusion, glycyrrhizin, curcumin and cinnamon possessed antioxidant properties with therapeutic potential in liver injury related to oxidative stress.
{"title":"Glycyrrhizin, Curcumin and Cinnamon Prevent From Concanavalin-A and Acetaminophen-Induced Liver Injury and Oxidative Stress in Mouse Model","authors":"Zulfia Hussain, Haroon Rashid, Aqsa Mushtaq, R. Siddique, Ashiq Ali","doi":"10.20448/journal.504.2021.81.1.9","DOIUrl":"https://doi.org/10.20448/journal.504.2021.81.1.9","url":null,"abstract":"Daily exposure to a number of xenobiotics is the major contributing factor to liver injury. The present study investigated the mechanism of hepatoprotection by glycyrrhizin, curcumin and cinnamon in two distinct models of hepatotoxicity i.e., by using Concanavalin-A (ConA) and Acetaminophen (APAP). For this evaluation, balb/c mice were pretreated with glycyrrhizin (200 mg/kg i.g.), curcumin (100 mg/kg i.g.) and cinnamon (200 mg/kg i.g.) extracts for 14 days followed by administration of ConA (15 mg/kg i.v.) and APAP (200 mg/kg i.p.) for 8 hours. At the end of the experiment, mice were dissected and blood and liver samples were collected for biochemical and histopathological analysis. Statistical analysis by using one-way ANOVA followed by DMR test was performed for the significance of results. The results showed that pre-treatment of glycyrrhizin, curcumin and cinnamon ameliorated the damaging effects of ConA and APAP on the liver as indicated by the serum transaminase enzymes and total protein levels. In addition, ConA and APAP exerted severe damage on liver tissues as confirmed from the histopathological analysis. However, glycyrrhizin, curcumin and cinnamon prevented liver injury, possibly through antioxidant mechanism. In conclusion, glycyrrhizin, curcumin and cinnamon possessed antioxidant properties with therapeutic potential in liver injury related to oxidative stress.","PeriodicalId":14015,"journal":{"name":"International Journal of Life-Sciences Scientific Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84716235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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