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Association depressive symptoms with memory function and social capital before and during COVID-19 in community-dwelling older adults in rural Japan: A retrospective study with a longitudinal data 日本农村社区老年人在 COVID-19 之前和期间的抑郁症状与记忆功能和社会资本的关系:采用纵向数据的回顾性研究
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-05-17 DOI: 10.1002/gps.6100
Yutaka Kunitake, Yoshiomi Imamura, Hiroko Kunitake, Junko Ohishi-Fukuchi, Jun Matsushima, Hiroshi Tateishi, Toru Murakawa-Hirachi, Ryohei Kojima, Yuta Sakemura, Jun Kikuchi, Takumi Shiraishi, Ayako Takamori, Toshihiro Morisaki, Shigeto Yamada, Akira Monji, Yoshito Mizoguchi

Objectives

This study aimed to investigate the impact of memory function and social capital on depressive symptoms during the COVID-19 pandemic among older adults in rural Japan.

Methods

A retrospective study with longitudinal data was conducted during COVID-19 from May 2021 to November 2021 (T2) in Kurogawa, Japan. The candidate population for this study was 145 with the following requirements: (1) older individuals aged 65 years or above who were registered in the Kurogawa study, and (2) those with previous data (from November 2016 to February 2020; T1 as pre-pandemic). Memory function was assessed using the Wechsler Memory Scale-Revised Logical Memory II delayed recall part A (LM II-DR). Depressive symptoms were assessed using the Japanese version of the 15-item Geriatric Depression Scale (GDS-15). Social capital was evaluated through civic participation, social cohesion, and reciprocity. Fear of the COVID-19 infection (FCV-19S) was evaluated.

Results

The final analysis included 96 participants (mean age = 81.0 years, SD = 4.8) Multivariate analysis for GDS-15 score by Mixed Model Repeated Measures (MMRM) revealed significant associations between LM II-DR (β = −0.13, 95% CI: −0.21–0.05, p = 0.002) and FCV-19S during COVID-19 (β = 0.08, 95% CI: 0.01–0.15, p = 0.02) with GDS-15 score. However, civic participation, social cohesion and reciprocity were not associated with GDS-15 score.

Conclusions

Among older adults in rural Japan, memory function and fear of the COVID-19 infection were significantly associated with depressive symptoms in MMRM analysis. However, social capital was not associated with depressive symptoms. This highlights the need to address memory function and fear of the COVID-19 infection in interventions for older adults during crises like the COVID-19 pandemic.

目的 本研究旨在调查 COVID-19 大流行期间日本农村老年人的记忆功能和社会资本对抑郁症状的影响。 方法 在 2021 年 5 月至 2021 年 11 月 COVID-19 期间(T2),在日本黑川市开展了一项纵向数据回顾性研究。本研究的候选人群为符合以下条件的 145 人:(1)在黑川研究中登记的 65 岁或以上的老年人;(2)有先前数据(2016 年 11 月至 2020 年 2 月;T1 为大流行前)的老年人。记忆功能采用韦氏记忆量表-修订版逻辑记忆II延迟回忆A部分(LM II-DR)进行评估。抑郁症状采用日文版 15 项老年抑郁量表(GDS-15)进行评估。社会资本通过公民参与、社会凝聚力和互惠性进行评估。对 COVID-19 感染恐惧(FCV-19S)进行了评估。 结果 最终分析包括 96 名参与者(平均年龄 = 81.0 岁,SD = 4.8),通过混合模型重复测量(MMRM)对 GDS-15 评分进行多变量分析,发现 LM II-DR (β = -0.13, 95% CI: -0.21-0.05, p = 0.002) 和 COVID-19 期间的 FCV-19S (β = 0.08, 95% CI: 0.01-0.15, p = 0.02) 与 GDS-15 评分有显著关联。然而,公民参与、社会凝聚力和互惠性与 GDS-15 分数无关。 结论 在 MMRM 分析中,在日本农村地区的老年人中,记忆功能和对 COVID-19 感染的恐惧与抑郁症状显著相关。然而,社会资本与抑郁症状无关。这突出表明,在 COVID-19 大流行等危机期间对老年人进行干预时,需要解决记忆功能和对 COVID-19 感染的恐惧问题。
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引用次数: 0
Loneliness and social isolation among informal carers of individuals with dementia: A systematic review and meta-analysis 痴呆症患者非正式照护者的孤独感和社会隔离:系统回顾与荟萃分析。
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-05-16 DOI: 10.1002/gps.6101
Xinqi Liao, Zhong Wang, Qinglin Zeng, Yanli Zeng

Objectives

This systematic review and meta-analysis aimed to determine the prevalence of loneliness and social isolation among informal carers of individuals with dementia and to identify potential influencing factors.

Methods

We conducted a comprehensive search across 10 electronic databases, including PubMed, Cochrane, Embase, Web of Science, PsycINFO, CINAHL, Scopus, Chinese Biomedical, China National Knowledge Internet, and WANFANG. Our search strategy covered the inception of the databases up to September 16, 2023, with an updated search conducted on March 8, 2024. Prevalence estimates of loneliness and social isolation, presented with 95% confidence intervals, were synthesized through meta-analysis. Subgroup analyses and meta-regression were employed to explore potential moderating variables and heterogeneity.

Results

The study encompassed 27 research papers involving 11,134 informal carers from 17 different countries. The pooled prevalence of loneliness among informal carers of individuals with dementia was 50.8% (95% CI: 41.8%–59.8%), while the pooled prevalence of social isolation was 37.1% (95% CI: 26.7%–47.6%). Subgroup analyses and meta-regression indicated that various factors significantly influenced the prevalence of loneliness and social isolation. These factors included the caregiving setting, study design, the intensity of loneliness, geographical location (continent), data collection time, and the choice of assessment tools.

Conclusions

This study underscores the substantial prevalence of loneliness and social isolation among informal carers of individuals with dementia. It suggests that policymakers and healthcare providers should prioritize the development of targeted interventions and support systems to alleviate loneliness and social isolation within this vulnerable population.

研究目的本系统综述和荟萃分析旨在确定孤独感和社会隔离在痴呆症患者非正式照护者中的流行程度,并找出潜在的影响因素:我们对10个电子数据库进行了全面检索,包括PubMed、Cochrane、Embase、Web of Science、PsycINFO、CINAHL、Scopus、中国生物医学、中国知网和万方数据库。我们的检索策略涵盖了从数据库建立之初到 2023 年 9 月 16 日的所有内容,并在 2024 年 3 月 8 日进行了更新检索。我们通过荟萃分析对孤独和社会隔离的流行率估计值进行了综合,并给出了 95% 的置信区间。采用分组分析和元回归来探讨潜在的调节变量和异质性:研究涵盖 27 篇研究论文,涉及来自 17 个不同国家的 11 134 名非正规照护者。在痴呆症患者的非正式照护者中,孤独感的总体流行率为50.8%(95% CI:41.8%-59.8%),而社会隔离的总体流行率为37.1%(95% CI:26.7%-47.6%)。分组分析和元回归表明,各种因素对孤独感和社会隔离感的发生率有显著影响。这些因素包括护理环境、研究设计、孤独感的强度、地理位置(大陆)、数据收集时间以及评估工具的选择:本研究强调了在痴呆症患者的非正式照护者中,孤独和社会隔离现象非常普遍。研究建议,政策制定者和医疗服务提供者应优先发展有针对性的干预措施和支持系统,以减轻这一弱势群体的孤独感和社会隔离感。
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引用次数: 0
Braden score can independently predict 90-day mortality in critically ill patients with dementia 布莱登评分可独立预测患有痴呆症的重症患者的 90 天死亡率。
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-05-16 DOI: 10.1002/gps.6093
Hongtao Cheng, Xinya Li, Xin Liang, Yonglan Tang, Fangxin Wei, Zichen Wang, Jun Lyu, Yu Wang
<div> <section> <h3> Background</h3> <p>Dementia is a significant cause of death in the older population and is becoming an important public health issue as the population ages and the prevalence of dementia increases. The Braden score is one of the most commonly used clinical tools to assess the risk of skin pressure injury in patients, and some studies have reported that it may reflect the state of frailty of patients. The present study attempted to explore the association between Braden score and 90-day mortality, pressure injury, and aspiration pneumonia in older patients with dementia in the intensive care unit (ICU).</p> </section> <section> <h3> Methods</h3> <p>The study involved extracting crucial data from the Medical Information Market for Intensive Care IV (MIMIC-IV) database using Structured Query Language, with a license certificate obtained after completing the necessary training and examination available on the MIMIC-IV website. A retrospective analysis was performed on older patients with dementia, aged 65 or older, who were first admitted to the ICU. Ninth and tenth revision International Classification of Diseases codes were used to identify patients with dementia. The primary outcome was 90-day mortality. Cox proportional hazards models were used to determine the association between Braden score and death, and hazard ratios (HR) and 95% confidence intervals (CI) were calculated. Propensity score matching and <i>E</i>-value assessments were employed for sensitivity analysis.</p> </section> <section> <h3> Results</h3> <p>A total of 2892 patients with a median age of approximately 85 years (interquartile range 78.74–89.59) were included, of whom 1625 were female (56.2%). Patients had a median Braden score of 14 (interquartile range 12–15) at ICU admission. Braden score at ICU admission was inversely associated with 90-day mortality risk after adjustment for demographics, severity of illness, treatment and medications, delirium, and sepsis (adjusted HR: 0.92, 95% CI: 0.87–0.98, <i>p</i> = 0.006). Patients were divided into two groups with a cut-off value of 15: high-risk group and low-risk group. Compared to the low-risk group (Braden score >15), the risk of 90-day mortality was significantly increased in the high-risk group (Braden score ≤15) (adjusted HR: 1.52, 95% CI: 1.10–2.09, <i>p</i> = 0.011, <i>E</i>-value: 2.01), the risk of pressure injury (adjusted OR: 2.62, 95% CI: 2.02–3.43, <i>E</i>-value: 2.62) and aspiration pneumonia (adjusted OR: 2.55, 95% CI: 1.84–3.61, <i>E</i>-value: 2.57) was also significantly higher.</p> </section> <section> <h3> Conclusions</h3> <p>The Braden score may be a quick and simp
背景:痴呆症是导致老年人死亡的一个重要原因,随着人口老龄化和痴呆症患病率的增加,痴呆症正成为一个重要的公共卫生问题。布莱登评分是评估患者皮肤压力损伤风险最常用的临床工具之一,一些研究报告称它可能反映了患者的虚弱状态。本研究试图探讨重症监护室(ICU)中老年痴呆症患者的布莱登评分与 90 天死亡率、压伤和吸入性肺炎之间的关系:研究使用结构化查询语言(Structured Query Language)从重症监护医学信息市场IV(MIMIC-IV)数据库中提取关键数据,并在完成必要的培训和考试后获得许可证书,许可证书可在MIMIC-IV网站上查阅。我们对首次入住重症监护室的 65 岁或以上老年痴呆症患者进行了回顾性分析。采用第九版和第十版国际疾病分类代码来识别痴呆症患者。主要结果是 90 天死亡率。采用 Cox 比例危险模型确定布莱登评分与死亡之间的关系,并计算出危险比 (HR) 和 95% 置信区间 (CI)。在敏感性分析中采用了倾向评分匹配和E值评估:共纳入 2892 名患者,中位年龄约为 85 岁(四分位间范围为 78.74-89.59),其中 1625 人为女性(56.2%)。患者入住重症监护室时的布莱登评分中位数为 14(四分位间范围为 12-15)。在对人口统计学、病情严重程度、治疗和用药、谵妄和脓毒症等因素进行调整后,ICU 入院时的 Braden 评分与 90 天死亡风险成反比(调整后 HR:0.92,95% CI:0.87-0.98,p = 0.006)。以 15 为临界值将患者分为两组:高风险组和低风险组。与低风险组(Braden 评分 >15)相比,高风险组(Braden 评分≤15)的 90 天死亡风险显著增加(调整后 HR:1.52,95% CI:1.10-2.09,P = 0.011,E 值:2.01),压力性损伤(调整后 OR:2.62,95% CI:2.02-3.43,E 值:2.62)和吸入性肺炎(调整后 OR:2.55,95% CI:1.84-3.61,E 值:2.57)的风险也显著升高:布莱登评分可能是一种快速、简单的筛查工具,可用于识别患有痴呆症的重症老年人出现不良后果的风险。
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引用次数: 0
Factors associated with institutionalization among the oldest old: Results based on the nationally representative study ‘old age in Germany (D80+)’ 高龄老人入住养老院的相关因素:基于 "德国老年(D80+)"全国代表性研究的结果。
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-05-15 DOI: 10.1002/gps.6099
André Hajek, Razak M. Gyasi, Hans-Helmut König

Objectives

To examine the factors associated with institutionalization among individuals aged 80 years and over in Germany (total sample and stratified by sex).

Methods/Design

We used data from the nationally representative ‘Old Age in Germany (D80+)’ (analytic sample: n = 9572 individuals), including individuals aged 80 years and over in Germany. Institutionalization (private living vs. institutionalization) served as an outcome measure. For the written interview, data collection took place from November 2020 to April 2021. Multiple logistic regressions of the overall sample (also stratified by sex) were applied.

Results

In the analytic sample, 10.2% (95% CI: 9.2%–11.3%) of the participants were institutionalized. The odds of being institutionalized were positively associated with being female (OR: 2.02, 95% CI: 1.08 to 3.80), being 90 years and over (compared to 80–84 years, OR: 1.67, 95% CI: 1.17 to 2.40), not being married (e.g., being single compared to being married: OR: 14.06, 95% CI: 6.73 to 29.37), higher education (e.g., high education compared to low education: OR: 1.88, 95% CI: 1.25 to 2.84), more favorable self-rated health (OR: 1.32, 95% CI: 1.07 to 1.62) and greater functional impairment (OR: 15.34, 95% CI: 11.91 to 19.74). Sex-stratified regressions were also conducted, mostly yielding similar results.

Conclusion

Our study highlighted the role of several sociodemographic factors (particularly marital status, e.g., being single) and functional impairment for the risk of institutionalization among the oldest old in Germany. This study confirms findings in studies in younger samples that functional decline is the main factor associated with institutionalization. As functional decline may be modifiable, efforts to maintain functional abilities may be important. This knowledge is important for relevant groups (such as clinicians and policy-makers) because it may guide early intervention and prevention efforts, can help allocate healthcare resources effectively and shape policies to support independent living. Further insights using longitudinal data is recommended.

目的:研究德国 80 岁及以上老人入住养老院的相关因素:研究德国 80 岁及以上老人入住养老院的相关因素(总样本和按性别分层):我们使用了具有全国代表性的 "德国老年(D80+)"数据(分析样本:n = 9572 人),其中包括德国 80 岁及以上的老年人。机构养老(私人生活与机构养老)是一项结果测量指标。书面访谈的数据收集时间为 2020 年 11 月至 2021 年 4 月。对总体样本(也按性别分层)进行了多重逻辑回归:在分析样本中,10.2%(95% CI:9.2%-11.3%)的参与者被机构收容。入住养老院的几率与女性(OR:2.02,95% CI:1.08-3.80)、90 岁及以上(与 80-84 岁相比,OR:1.67,95% CI:1.17-2.40)、未婚(例如,单身与已婚相比,OR:14.06,95% CI:1.17-2.40)呈正相关:OR:14.06,95% CI:6.73 至 29.37)、高学历(例如,高学历与低学历相比:OR:1.88,95% CI:1.25 至 2.84)、自我评定健康状况更佳(OR:1.32,95% CI:1.07 至 1.62)和功能障碍更严重(OR:15.34,95% CI:11.91 至 19.74)。我们还进行了性别分层回归,结果大多相似:我们的研究强调了一些社会人口因素(尤其是婚姻状况,如单身)和功能障碍对德国高龄老人入院风险的影响。这项研究证实了年轻样本的研究结果,即功能衰退是与机构养老相关的主要因素。由于功能衰退可能是可以改变的,因此努力保持功能能力可能很重要。这一知识对相关群体(如临床医生和政策制定者)非常重要,因为它可以指导早期干预和预防工作,有助于有效分配医疗资源和制定支持独立生活的政策。建议利用纵向数据进一步深入研究。
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引用次数: 0
The landscape of inequalities in dementia across Europe: First insights from the INTERDEM taskforce 欧洲痴呆症的不平等状况:INTERDEM 工作组的初步见解。
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-05-08 DOI: 10.1002/gps.6096
Clarissa Giebel, Emma Harding, Anna Volkmer, Ilaria Chirico, Louise Hopper, Dorota Szczesniak, Catherine V. Talbot, Ana Diaz-Ponce, Dianne Gove, Martin Knapp, Louise Robinson, Malayka Rahman-Amin, Rene Thyrian, Kerry Hanna, INTERDEM Taskforce on Inequalities in Dementia Care

Background

Getting a diagnosis of dementia does not equate to equitable access to care. People with dementia and unpaid carers face many barriers to care, which can vary within, and across, different countries and cultures. With little evidence across different countries, the aim of this scoping exercise was to identify the different and similar types of inequalities in dementia across Europe, and provide recommendations for addressing these.

Methods

We conducted a brief online survey with INTERDEM and INTERDEM Academy members across Europe, and with members of Alzheimer Europe's European Working Group of People with Dementia and Carers in February and March 2023. Members were asked about whether inequalities in dementia care existed within their country; if yes, to highlight three key inequalities. Responses on barriers were coded into groups, and frequencies of inequalities were calculated. Highlighted inequalities were discussed and prioritised at face-to-face and virtual consensus meetings in England, Ireland, Italy, and Poland, involving people with dementia, unpaid carers, health and social care providers, and non-profit organisations.

Results

Forty-nine academics, PhD students, people with dementia and unpaid carers from 10 countries (Belgium, Denmark, Germany, Greece, Ireland, Italy, Poland, Malta, Netherlands, UK) completed the survey. The most frequently identified inequalities focused on unawareness and lack of information, higher level system issues (i.e. lack of communication among care professionals), lack of service suitability, and stigma. Other barriers included workforce training and knowledge, financial costs, culture and language, lack of single-point-of-contact person, age, and living location/postcode lottery. There was general consensus among people living dementia and care providers of unawareness as a key barrier in different European countries, with varied priorities in Ireland depending on geographical location.

Conclusions

These findings provide a first insight on dementia inequalities across Europe, generate cross-country learnings on how to address these inequalities in dementia, and can underpin further solution-focused research that informs policy and key decision makers to implement changes.

背景:被诊断出患有痴呆症并不等于可以公平地获得护理。痴呆症患者和无偿照护者在获得照护方面面临着许多障碍,这些障碍在不同的国家和文化中会有所不同。由于不同国家之间的证据很少,此次范围界定工作旨在确定欧洲各国在痴呆症方面存在的不同和相似类型的不平等现象,并为解决这些问题提供建议:我们在 2023 年 2 月和 3 月对欧洲的 INTERDEM 和 INTERDEM 学院成员,以及欧洲阿尔茨海默氏症欧洲痴呆症患者和照护者工作组的成员进行了简短的在线调查。成员们被问及他们的国家在痴呆症护理方面是否存在不平等现象;如果存在,请强调三个主要的不平等现象。有关障碍的回答被编为若干组,不平等的频率也被计算出来。在英格兰、爱尔兰、意大利和波兰举行的面对面和虚拟共识会议上,痴呆症患者、无偿照护者、医疗和社会护理服务提供者以及非营利组织参与了讨论,并对突出的不平等现象进行了优先排序:来自 10 个国家(比利时、丹麦、德国、希腊、爱尔兰、意大利、波兰、马耳他、荷兰、英国)的 49 名学者、博士生、痴呆症患者和无偿照护者完成了调查。最常发现的不平等现象集中在不了解和缺乏信息、更高层次的系统问题(即护理专业人员之间缺乏沟通)、缺乏服务适用性以及耻辱感等方面。其他障碍包括劳动力培训和知识、经济成本、文化和语言、缺乏单点联系人、年龄以及居住地点/邮政编码抽签。欧洲各国的痴呆症患者和护理服务提供者普遍认为,不了解痴呆症是主要障碍,而爱尔兰则因地理位置不同而有不同的重点:这些研究结果首次揭示了欧洲痴呆症的不平等现象,就如何解决这些痴呆症的不平等问题提供了跨国经验,并为进一步开展以解决方案为重点的研究奠定了基础,从而为政策制定者和主要决策者提供了实施变革的信息。
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引用次数: 0
“WOOP is my safe haven”: A qualitative feasibility and acceptability study of the Wish Outcome Obstacle Plan (WOOP) intervention for spouses of people living with early-stage dementia "WOOP是我的避风港针对早期痴呆症患者配偶的 "愿望结果障碍计划"(WOOP)干预的可行性和可接受性定性研究
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-04-30 DOI: 10.1002/gps.6092
Emily L. Mroz, Anna E. Schwartz, Sarah Valeika, Gabriele Oettingen, Richard Marottoli, Daniel David, Ashley Hagaman, Donna Fedus, Joan K. Monin

Objectives

As symptoms emerge and worsen in people living with dementia, their spouses can benefit from behavioral interventions to support their adjustment as a care partner. The Wish Outcome Obstacle Plan (WOOP) intervention improves the well-being of spouses of people living with dementia early in the disease course, but intervention mechanisms and opportunities for improvement are unclear. The present study gave voice to spouses who participated in a trial of WOOP, describing how WOOP was incorporated into their lives and how it could be improved for future implementation.

Method

For this qualitative study, we conducted longitudinal semi-structured interviews among 21 spouses of people living with dementia (three interviews over three months; 63 interviews total). Codebook thematic analysis was performed.

Results

Three meta-themes were derived: (1) assessing baseline strengths and limitations of WOOP, (2) learning from experience, and (3) fine-tuning and sustaining WOOP. Participants described how WOOP addressed their interpersonal and emotional stressors, their responses to behaviors of the person living with dementia, and their relationship quality. Considerations for future intervention delivery (e.g., solo vs. in group settings) and instructions (e.g., encouraging writing vs. thinking through the four steps of WOOP) were identified as areas of improvement.

Conclusions

WOOP was described as a practical, feasible, and desirable intervention for spouses at the early stages of their partner's dementia. Participants made WOOP easier to incorporate in their everyday lives by adapting the design into a mental exercise that they used as needed. Suggestions from participants specified how to make the everyday use of WOOP more feasible, sustainable, and applicable in a variety of contexts.

Trial Registration

ClinicalTrials.gov HIC 2000021852.

目标 随着痴呆症患者症状的出现和恶化,他们的配偶可以从行为干预中受益,以支持他们作为护理伙伴的调整。愿望结果障碍计划(WOOP)干预措施可在痴呆症患者病程早期改善其配偶的福祉,但干预机制和改善机会尚不明确。本研究倾听了参与 WOOP 试验的配偶的心声,描述了 WOOP 如何融入他们的生活,以及如何在今后的实施中加以改进。 方法 在这项定性研究中,我们对 21 名痴呆症患者的配偶进行了纵向半结构式访谈(三个月内进行三次访谈,共 63 次访谈)。我们进行了编码本主题分析。 结果 得出了三个元主题:(1) 评估 WOOP 的基线优势和局限性,(2) 从经验中学习,以及 (3) 微调和维持 WOOP。参与者描述了 WOOP 如何解决他们的人际关系和情绪压力、他们对痴呆症患者行为的反应以及他们的关系质量。他们还指出了未来干预实施的注意事项(例如,单独实施与在小组环境中实施)和指导(例如,鼓励书写与通过 WOOP 的四个步骤进行思考),这些都是需要改进的地方。 结论 WOOP 被认为是配偶在其伴侣痴呆症早期阶段的一种实用、可行和理想的干预措施。参与者将 WOOP 的设计改编成了他们根据需要使用的心理练习,从而使 WOOP 更容易融入他们的日常生活。参与者提出的建议具体说明了如何使 WOOP 的日常使用更加可行、可持续,并适用于各种情况。 试验注册 ClinicalTrials.gov HIC 2000021852。
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引用次数: 0
Executive function deficits in patients with the first episode of late-life depression before and after SSRI treatment: A pilot fMRI study 首次发作的晚期抑郁症患者在接受 SSRI 治疗前后的执行功能障碍:fMRI 试验研究
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-04-30 DOI: 10.1002/gps.6095
Chaomeng Liu, Li Li, Weigang Pan, Peixian Mao, Li Ren, Bing Li, Xin Ma

Background

Executive function deficits (EFD) in late-life depression (LLD) has been reported to be associated with antidepressant treatment resistance, increased disability, and poor quality of life. However, the underlying neutral mechanisms of EFD in patients with the first episode of LLD remains unclear.

Methods

A total of 27 patients with first-episode, drug-naive LLD and 27 non-depressed controls (NC) were recruited for the present research. Participants underwent the Trail Making Test, the 17-item Hamilton depression rating scale (HAMD-17) test, and task-state functional magnetic resonance imaging scans under the neutral Stroop task. LLD patients' executive functions, depressive symptoms, and brain activity were examined again after 6 months of antidepressant treatment.

Results

Of the 27 LLD patients, 16 cases completed 6-month follow-ups. Patients in the LLD baseline group spent more time on the Trail Making Test A test than those in the NC group (p < 0.05). In the presence of an incongruency between the word color and meaning, the accuracy rate of the neutral Stroop task in the LLD baseline group was lower, and the reaction time was greater than that in the NC group, with statistically significant difference (p < 0.05). The HAMD-17 score in the LLD follow-up group was significantly lower than that in the LLD baseline group (p < 0.05). More activated brain regions were present in the LLD baseline group than in the NC group when performing the neutral Stroop task. Compared with the LLD baseline group, abnormal activation of relevant brains in the cingulate-prefrontal-parietal network of LLD patients still existed in the LLD follow-up group.

Conclusions

LLD patients engaged more brain areas than the NC group while performing the neutral Stroop task. Abnormal activation of the cingulate-prefrontal-parietal network could be a contributing factor to EFD in LLD.

Trial registration

ChiCTR, ChiCTR2100042370 (Date of registration: 21/01/2021).

Limits

We didn't enroll enough first-episode, LLD patients, the robustness of the findings need to be confirmed by large sample clinical trials.

背景 据报道,晚期抑郁症(LLD)患者的执行功能障碍(EFD)与抗抑郁治疗抵抗、残疾增加和生活质量低下有关。然而,首次发病的晚期抑郁症患者的EFD的潜在中性机制仍不清楚。 方法 本研究共招募了27名首次发病、未服药的LLD患者和27名非抑郁对照组(NC)。研究人员对患者进行了 "追踪测试"(Trail Making Test)、17项汉密尔顿抑郁评分量表(HAMD-17)测试以及中性Stroop任务下的任务态功能磁共振成像扫描。经过6个月的抗抑郁治疗后,再次对LLD患者的执行功能、抑郁症状和大脑活动进行检查。 结果 在27名LLD患者中,有16人完成了6个月的随访。与NC组相比,LLD基线组患者花在 "路径制作测试A "上的时间更长(p <0.05)。在词色与词义不一致的情况下,LLD基线组患者中性Stroop任务的正确率低于NC组,反应时间长于NC组,差异有统计学意义(p <0.05)。LLD 随访组的 HAMD-17 评分明显低于 LLD 基线组(p < 0.05)。在执行中性 Stroop 任务时,LLD 基线组比 NC 组有更多激活的脑区。与 LLD 基线组相比,LLD 随访组中 LLD 患者扣带回-前额叶-顶叶网络中的相关脑区仍存在异常激活。 结论 LLD患者在执行中性Stroop任务时比NC组调动了更多的脑区。扣带回-前额叶-顶叶网络的异常激活可能是导致LLD患者EFD的一个因素。 试验注册号:ChiCTR,ChiCTR2100042370(注册日期:2021年1月21日)。 局限性 我们没有招募足够的首次发病的LLD患者,研究结果的稳健性需要通过大样本临床试验来证实。
{"title":"Executive function deficits in patients with the first episode of late-life depression before and after SSRI treatment: A pilot fMRI study","authors":"Chaomeng Liu,&nbsp;Li Li,&nbsp;Weigang Pan,&nbsp;Peixian Mao,&nbsp;Li Ren,&nbsp;Bing Li,&nbsp;Xin Ma","doi":"10.1002/gps.6095","DOIUrl":"https://doi.org/10.1002/gps.6095","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Executive function deficits (EFD) in late-life depression (LLD) has been reported to be associated with antidepressant treatment resistance, increased disability, and poor quality of life. However, the underlying neutral mechanisms of EFD in patients with the first episode of LLD remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 27 patients with first-episode, drug-naive LLD and 27 non-depressed controls (NC) were recruited for the present research. Participants underwent the Trail Making Test, the 17-item Hamilton depression rating scale (HAMD-17) test, and task-state functional magnetic resonance imaging scans under the neutral Stroop task. LLD patients' executive functions, depressive symptoms, and brain activity were examined again after 6 months of antidepressant treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 27 LLD patients, 16 cases completed 6-month follow-ups. Patients in the LLD baseline group spent more time on the Trail Making Test A test than those in the NC group (<i>p</i> &lt; 0.05). In the presence of an incongruency between the word color and meaning, the accuracy rate of the neutral Stroop task in the LLD baseline group was lower, and the reaction time was greater than that in the NC group, with statistically significant difference (<i>p</i> &lt; 0.05). The HAMD-17 score in the LLD follow-up group was significantly lower than that in the LLD baseline group (<i>p</i> &lt; 0.05). More activated brain regions were present in the LLD baseline group than in the NC group when performing the neutral Stroop task. Compared with the LLD baseline group, abnormal activation of relevant brains in the cingulate-prefrontal-parietal network of LLD patients still existed in the LLD follow-up group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>LLD patients engaged more brain areas than the NC group while performing the neutral Stroop task. Abnormal activation of the cingulate-prefrontal-parietal network could be a contributing factor to EFD in LLD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial registration</h3>\u0000 \u0000 <p>ChiCTR, ChiCTR2100042370 (Date of registration: 21/01/2021).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Limits</h3>\u0000 \u0000 <p>We didn't enroll enough first-episode, LLD patients, the robustness of the findings need to be confirmed by large sample clinical trials.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"39 5","pages":""},"PeriodicalIF":4.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140814251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National surveillance using a clinical quality indicator for prolonged antipsychotic use among older Australians with dementia who access aged care services 使用临床质量指标对接受老年护理服务的患有痴呆症的澳大利亚老年人长期使用抗精神病药物的情况进行全国监测
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-04-27 DOI: 10.1002/gps.6089
Janet K. Sluggett, Gillian E. Caughey, Tracy Air, Monica Cations, Catherine E. Lang, Stephanie A. Ward, Susannah Ahern, Xiaoping Lin, Kasey Wallis, Maria Crotty, Maria C. Inacio

Objectives

Dementia guidelines recommend antipsychotics are only used for behavioral and psychological symptoms when non-drug interventions fail, and to regularly review use. Population-level clinical quality indicators (CQIs) for dementia care in permanent residential aged care (PRAC) typically monitor prevalence of antipsychotic use but not prolonged use. This study aimed to develop a CQI for antipsychotic use >90 days and examine trends, associated factors, and variation in CQI incidence; and examine duration of the first episode of use among individuals with dementia accessing home care packages (HCPs) or PRAC.

Methods

Retrospective cohort study, including older individuals with dementia who accessed HCPs (n = 50,257) or PRAC (n = 250,196). Trends in annual CQI incidence (2011–12 to 2015–16) and associated factors were determined using Poisson regression. Funnel plots examined geographical and facility variation. Time to antipsychotic discontinuation was estimated among new antipsychotic users accessing HCP (n = 2367) and PRAC (n = 15,597) using the cumulative incidence function.

Results

Between 2011–12 and 2015–16, antipsychotic use for >90 days decreased in HCP recipients from 10.7% (95% CI 10.2–11.1) to 10.1% (95% CI 9.6–10.5, adjusted incidence rate ratio (aIRR) 0.97 (95% CI 0.95–0.98)), and in PRAC residents from 24.5% (95% CI 24.2–24.7) to 21.8% (95% CI 21.5–22.0, aIRR 0.97 (95% CI 0.96–0.98)). Prior antipsychotic use (both cohorts) and being male and greater socioeconomic disadvantage (PRAC cohort) were associated with higher CQI incidence. Little geographical/facility variation was observed. Median treatment duration in HCP and PRAC was 334 (interquartile range [IQR] 108–958) and 555 (IQR 197–1239) days, respectively.

Conclusions

While small decreases in antipsychotic use >90 days were observed between 2011–12 and 2015–16, findings suggest antipsychotic use among aged care recipients with dementia can be further minimized.

目标 痴呆症指南建议只有在非药物干预无效时才使用抗精神病药物来治疗行为和心理症状,并定期检查使用情况。针对永久性老年寄宿护理机构(PRAC)痴呆症护理的人群临床质量指标(CQI)通常监测抗精神病药物的使用率,但不监测长期使用情况。本研究旨在制定抗精神病药物使用 90 天的 CQI,并检查 CQI 发生率的趋势、相关因素和变化;同时检查使用家庭护理套餐(HCPs)或 PRAC 的痴呆患者首次使用的持续时间。 方法 回顾性队列研究,包括使用家庭护理包(50257 人)或 PRAC(250196 人)的老年痴呆患者。采用泊松回归法确定了年度 CQI 发生率趋势(2011-12 年至 2015-16 年)和相关因素。漏斗图检验了地域和设施的差异。使用累积发生率函数估算了访问 HCP(n = 2367)和 PRAC(n = 15597)的抗精神病药物新用户停用抗精神病药物的时间。 结果 2011-12年至2015-16年期间,HCP接受者90天内使用抗精神病药的比例从10.7%(95% CI 10.2-11.1)降至10.1%(95% CI 9.6-10.5,调整后发病率比(aIRR)0.97(95% CI 0.95-0.98)),PRAC居民从24.5%(95% CI 24.2-24.7)降至21.8%(95% CI 21.5-22.0,aIRR 0.97(95% CI 0.96-0.98))。曾使用抗精神病药物(两个队列)、男性和社会经济地位较低(PRAC队列)与较高的CQI发生率相关。观察到的地域/机构差异很小。HCP 和 PRAC 的中位治疗时间分别为 334 天(四分位数间距 [IQR] 108-958)和 555 天(IQR 197-1239)。 结论 虽然在 2011-12 年至 2015-16 年期间,抗精神病药物的使用 >90 天数略有减少,但研究结果表明,可以进一步最大限度地减少痴呆症老年护理对象中抗精神病药物的使用。
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引用次数: 0
Lifestyle for brain health and cognitive functioning in midlife to early late-life New Zealanders: Utility of the LIBRA index 新西兰中年至晚年早期人群大脑健康和认知功能的生活方式:LIBRA 指数的实用性
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-04-26 DOI: 10.1002/gps.6091
Susanne Röhr, Christine Stephens, Fiona Alpass

Objectives

There is enormous potential to improve brain health and reduce the risk of cognitive decline and dementia based on modifiable risk factors. The Lifestyle for Brain Health (LIBRA) index was developed to quantify modifiable dementia risk or room for brain health improvement. The objective of the study was to investigate the utility of the LIBRA index in relation to cognitive functioning in a midlife to early late-life sample of New Zealanders.

Methods

A subsample (n = 1001) of the longitudinal New Zealand Health, Work and Retirement (NZHWR) study completed face-to-face cognitive assessments using the ‘Kiwi’ Addenbrooke's Cognitive Examination—Revised (ACE-R) in 2010 and again in 2012, in addition to completing biennial NZHWR surveys on socioeconomic, health and wellbeing aspects. The LIBRA index was calculated incorporating information on 8 out of 12 modifiable health and lifestyle factors for dementia. Unadjusted and adjusted regression models and mixed effects models were used to inspect associations of LIBRA with cognitive functioning, cognitive impairment, and cognitive decline.

Results

The analytical sample (n = 881 [88.0%], after considering exclusion criteria and missing data) had a mean age of 63.1 (SD = 6.5) years, 53.3% were female, 26.2% were Māori, and 61.7% were highly educated. Higher LIBRA scores (indicating higher modifiable dementia risk) were associated with lower cognitive functioning (B = −0.33, 95% CI = −0.52;−0.15, p < 0.001) and a higher likelihood of cognitive impairment (OR = 1.22, 95% CI = 1.04; 1.42, p = 0.013), but did not predict cognitive decline over 2 years (B = −0.03, 95% CI = −0.22; 0.16, p = 0.766), adjusted for age, age2, gender, education, and ethnicity.

Conclusions

The LIBRA index indicated promising utility for quantifying modifiable dementia risk in midlife and early late-life New Zealanders. For local use, refinement of the LIBRA index should consider cultural differences in health and lifestyle risk factors, and further investigate its utility with a wider range of modifiable factors over a longer observation period.

目标 基于可改变的风险因素,改善大脑健康、降低认知能力下降和痴呆症风险的潜力巨大。脑健康生活方式(LIBRA)指数旨在量化可改变的痴呆症风险或改善脑健康的空间。本研究的目的是调查 LIBRA 指数在新西兰中年至晚年早期样本中与认知功能相关的实用性。 方法 新西兰健康、工作和退休(NZHWR)纵向研究的一个子样本(n = 1001)在2010年和2012年使用 "Kiwi "Addenbrooke认知检查-修订版(ACE-R)完成了面对面的认知评估,此外还完成了每两年一次的NZHWR社会经济、健康和福利方面的调查。LIBRA指数的计算包含了12个可改变的痴呆症健康和生活方式因素中8个因素的信息。采用未调整和调整回归模型以及混合效应模型来检验 LIBRA 与认知功能、认知障碍和认知能力下降之间的关联。 结果 分析样本(n = 881 [88.0%],已考虑排除标准和缺失数据)的平均年龄为 63.1 (SD = 6.5)岁,53.3%为女性,26.2%为毛利人,61.7%受过高等教育。LIBRA得分越高(表明可改变的痴呆风险越高),认知功能越低(B = -0.33,95% CI = -0.52;-0.15,p <0.001),出现认知障碍的可能性越高(OR = 1.22,95% CI = 1.04; 1.42,p = 0.013),但经年龄、年龄2、性别、教育程度和种族调整后,并不能预测2年内认知能力的下降(B = -0.03,95% CI = -0.22; 0.16,p = 0.766)。 结论 LIBRA指数可用于量化中年和晚年新西兰人可改变的痴呆风险。在本地使用时,LIBRA指数的改进应考虑到健康和生活方式风险因素的文化差异,并在更长的观察期内进一步研究其在更广泛的可改变因素中的效用。
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引用次数: 0
The effects of pension on depressive symptoms in Chinese older adults: A moderated multiple mediator model 养老金对中国老年人抑郁症状的影响:多中介调节模型
IF 4 3区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2024-04-26 DOI: 10.1002/gps.6088
Boye Fang, Youwei Wang, Qian Sun

Objectives

This study investigates the impact of pension on depressive symptoms among Chinese older adults. Additional effort is made to test the mediating effect of multidimensional downward intergenerational support and the moderating effect of age on this relationship.

Methods

A total of 1828 Chinese older community-dwellers who met our inclusion criteria are drawn from the 2018 China Health and Retirement Longitudinal Study. Multivariate regression modeling is applied to analyze the effect of pensions on depressive symptoms of older adults. Additionally, bootstrap method with resampling strategies is used to estimate the mediating effect of three dimensions of downward intergenerational support (instrumental, emotional, and financial support). Further, Johnson-Neyman technique is employed to analysis and visualize the moderating effect of age.

Results

The findings reveal a significant inverse relationship between pension levels and depressive symptoms (B = −6.664, SE = 2.826, p < 0.05). The analysis shows that downward intergenerational emotional support (B = −0.195, Boot SE = 0.103, 95% Boot CI [−0.404, −0.003]) serves as a partial mediator in this relationship. Furthermore, the results highlight the moderating role of age in the linkage between pension and depressive symptoms (B = 0.065, SE = 0.039, p < 0.1).

Discussion

This investigation is pioneering in simultaneously assessing the mediating role of multidimensional downward intergenerational support and the moderating effect of age in the context of pension and depressive symptoms. The study underscores the necessity of an interdisciplinary approach in devising comprehensive intervention strategies. These should encompass pension policy consultation, respite services, and other crucial elements aimed at mitigating the severity or reducing the risk of depressive symptoms among the older adults.

研究目的 本研究探讨了养老金对中国老年人抑郁症状的影响。此外,还检验了多维度向下代际支持的中介效应以及年龄对这一关系的调节效应。 方法 从 2018 年中国健康与退休纵向研究中选取符合纳入标准的 1828 名中国老年社区居民。采用多元回归模型分析养老金对老年人抑郁症状的影响。此外,还采用了带有重采样策略的引导法来估计向下代际支持的三个维度(工具支持、情感支持和经济支持)的中介效应。此外,还采用了约翰逊-奈曼(Johnson-Neyman)技术对年龄的调节效应进行分析和可视化。 结果 研究结果显示,养老金水平与抑郁症状之间存在明显的反向关系(B = -6.664,SE = 2.826,p < 0.05)。分析表明,代际情感支持的下降(B = -0.195,Boot SE = 0.103,95% Boot CI [-0.404,-0.003])是这一关系的部分调解因素。此外,研究结果还强调了年龄在养老金与抑郁症状之间关系中的调节作用(B = 0.065,SE = 0.039,p <0.1)。 讨论 本研究开创性地同时评估了多维向下代际支持的中介作用和年龄在养老金与抑郁症状中的调节作用。这项研究强调了采用跨学科方法制定综合干预策略的必要性。这些战略应包括养老金政策咨询、临时服务和其他旨在减轻老年人抑郁症状的严重程度或降低其风险的重要因素。
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International Journal of Geriatric Psychiatry
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