Background: Threatened abortion during the first trimester of pregnancy may be due to many reasons including subchorionic haematoma (SCH).The presence of SCH can have several adverse effects on pregnancy outcome. AIM: To determine the impact of SCH identified during the first trimester of pregnancy on adverse pregnancy outcomes. Material and Methods: This was a prospective study conducted by enrolling 151 women each with and without Subchorionic Haematoma. All women were followed until delivery to observe the outcome of the pregnancy. Results: Out of 151 women in each of the two groups- 110 (72.8%) women with SCH and 118 (78.1%) women without SCH gave birth to a live neonate. The relative risk of pregnancy wastage (spontaneous abortion, IUFD & stillbirth) for the women with SCH and without SCH was 1.22 (95% CI 0.81 - 1.82; p-value = 0.33). 27% and 11.5% of pregnant women with and without SCH had a preterm delivery (p = 0.004). Conclusion- The mere presence of SCH did not increase the risk of pregnancy loss but there was increased incidence of IUGR,preterm bith,antepartum haemorrhage.
{"title":"Obstetrical outcome of subchorionic hematoma in first trimester","authors":"Pooja Bairwa, Nupur Hooja, Pawan Agrawal, Babita Panwar, Krupa Verma, Mónika","doi":"10.53771/ijlsra.2023.5.1.0066","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.5.1.0066","url":null,"abstract":"Background: Threatened abortion during the first trimester of pregnancy may be due to many reasons including subchorionic haematoma (SCH).The presence of SCH can have several adverse effects on pregnancy outcome. AIM: To determine the impact of SCH identified during the first trimester of pregnancy on adverse pregnancy outcomes. Material and Methods: This was a prospective study conducted by enrolling 151 women each with and without Subchorionic Haematoma. All women were followed until delivery to observe the outcome of the pregnancy. Results: Out of 151 women in each of the two groups- 110 (72.8%) women with SCH and 118 (78.1%) women without SCH gave birth to a live neonate. The relative risk of pregnancy wastage (spontaneous abortion, IUFD & stillbirth) for the women with SCH and without SCH was 1.22 (95% CI 0.81 - 1.82; p-value = 0.33). 27% and 11.5% of pregnant women with and without SCH had a preterm delivery (p = 0.004). Conclusion- The mere presence of SCH did not increase the risk of pregnancy loss but there was increased incidence of IUGR,preterm bith,antepartum haemorrhage.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81835298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-30DOI: 10.53771/ijlsra.2023.5.1.0067
S. Miltonprabu, K. Shagirtha
Arsenic (As) and its compounds were widely used as a medicine in the past years for the treatment of such diseases as diabetes, psoriasis, syphilis, skin ulcers and joint diseases. Long-term exposure to arsenic from drinking-water and food can cause cancer and skin lesions. It has also been associated with cardiovascular, lung diseases and diabetes. Its exposure could cause severe oxidative stress and fibrotic injuries in lung tissue. Due to the antioxidant and anti-inflammatory properties of siibinin (SB), the present study investigated its effects on As-induced pulmonary toxicity. For the experimental study, twenty four male rats were randomly categorized into four groups of six. Initially, the first and fourth groups were treated intragastrically with normal saline and SB (80 mg/kg) for 28 consecutive days, respectively. The second and third groups were treated with As (5mg/kg BW) and As along with SB (80 mg/kg BW) for 28 consecutive days, respectively, At the end of the experimental tenure, the animals were anesthetized with ketamine and xylazine, and lung tissue samples were collected for biochemical and histological examinations. The results showed that As significantly increased hydroxyproline (HP) and lipid peroxidation (LPO) and decreased the lung tissue antioxidant capacity. In addition, myeloperoxidase (MPO) activity increased significantly, while glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activity declined substantially. The administration of therapeutic doses of SB could prevent the oxidative, fibrotic, and inflammatory effects of As-induced lung toxicity, and these changes were consistent with histological observations. In conclusion, SB may improve the antioxidantdefense of lung tissue and prevent the spread of inflammation and the development of As-induced fibrotic injuries by enhancing antioxidant enzymes and preventing inflammatory cell infiltration.
{"title":"Silibinin extenuates arsenic instigated oxidative pulmonary damage and fibrosis in rats","authors":"S. Miltonprabu, K. Shagirtha","doi":"10.53771/ijlsra.2023.5.1.0067","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.5.1.0067","url":null,"abstract":"Arsenic (As) and its compounds were widely used as a medicine in the past years for the treatment of such diseases as diabetes, psoriasis, syphilis, skin ulcers and joint diseases. Long-term exposure to arsenic from drinking-water and food can cause cancer and skin lesions. It has also been associated with cardiovascular, lung diseases and diabetes. Its exposure could cause severe oxidative stress and fibrotic injuries in lung tissue. Due to the antioxidant and anti-inflammatory properties of siibinin (SB), the present study investigated its effects on As-induced pulmonary toxicity. For the experimental study, twenty four male rats were randomly categorized into four groups of six. Initially, the first and fourth groups were treated intragastrically with normal saline and SB (80 mg/kg) for 28 consecutive days, respectively. The second and third groups were treated with As (5mg/kg BW) and As along with SB (80 mg/kg BW) for 28 consecutive days, respectively, At the end of the experimental tenure, the animals were anesthetized with ketamine and xylazine, and lung tissue samples were collected for biochemical and histological examinations. The results showed that As significantly increased hydroxyproline (HP) and lipid peroxidation (LPO) and decreased the lung tissue antioxidant capacity. In addition, myeloperoxidase (MPO) activity increased significantly, while glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activity declined substantially. The administration of therapeutic doses of SB could prevent the oxidative, fibrotic, and inflammatory effects of As-induced lung toxicity, and these changes were consistent with histological observations. In conclusion, SB may improve the antioxidantdefense of lung tissue and prevent the spread of inflammation and the development of As-induced fibrotic injuries by enhancing antioxidant enzymes and preventing inflammatory cell infiltration.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"169 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73060554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To enhance the cellular uptake and chemotherapeutic efficacy of a current chemotherapeutic medication, a nanoparticle drug carrier technology has been designed. Due to their distinctive electrical and optical characteristics, gold nanoparticles (Au NPs) have recently demonstrated intriguing medical and military uses. In the event that they come into touch with a biological system, little is known about their biocompatibility. Metallic nanoparticles have been successfully utilized for a kind of biological applications. A drug delivery system known as Au – PEG – PAMAM – DOX was produced by conjugating the dendrimer with the anti-cancer chemical doxorubicin (DOX) via an amide bond. The amount of DOX released from Au – PEG – PAMAM – DOX at a natural pH was negligible, but this amount significantly increased in an environment with a weak acidic milieu, according to studies on the release of medicines from acellular sources. A research into the intracellular release of the medication was carried out with the assistance of confocal laser scanning microscopy (CLSM). Recently conjugation to the nanosystem, In vitro viability experiments revealed an increase in the associated DOX cytotoxicity that could not be attributable to carrier components. This indicates that the effectiveness of the DOX was increased. In light of this, it has been hypothesized that the newly created pH-triggered multifunctional Au NPs- DOX nanoparticle system could pave the way for a viable platform for the intracellular delivery of a range of anticancer medicines. In the current study, the common Au NPs synthesis techniques and their well-established uses in diverse needs, particularly in biological sensing applications.
{"title":"The role of gold nanoparticles in anticancer activity","authors":"Murtadha M-Hussein A-kadhim, A-Kadhim, Ameer Jawad Hadi, Siham Adnan Abdulsada","doi":"10.53771/ijlsra.2023.5.1.0064","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.5.1.0064","url":null,"abstract":"To enhance the cellular uptake and chemotherapeutic efficacy of a current chemotherapeutic medication, a nanoparticle drug carrier technology has been designed. Due to their distinctive electrical and optical characteristics, gold nanoparticles (Au NPs) have recently demonstrated intriguing medical and military uses. In the event that they come into touch with a biological system, little is known about their biocompatibility. Metallic nanoparticles have been successfully utilized for a kind of biological applications. A drug delivery system known as Au – PEG – PAMAM – DOX was produced by conjugating the dendrimer with the anti-cancer chemical doxorubicin (DOX) via an amide bond. The amount of DOX released from Au – PEG – PAMAM – DOX at a natural pH was negligible, but this amount significantly increased in an environment with a weak acidic milieu, according to studies on the release of medicines from acellular sources. A research into the intracellular release of the medication was carried out with the assistance of confocal laser scanning microscopy (CLSM). Recently conjugation to the nanosystem, In vitro viability experiments revealed an increase in the associated DOX cytotoxicity that could not be attributable to carrier components. This indicates that the effectiveness of the DOX was increased. In light of this, it has been hypothesized that the newly created pH-triggered multifunctional Au NPs- DOX nanoparticle system could pave the way for a viable platform for the intracellular delivery of a range of anticancer medicines. In the current study, the common Au NPs synthesis techniques and their well-established uses in diverse needs, particularly in biological sensing applications.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84457841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The objective of this study is to determine the presence of antibiotic residues in the water environment. Methodology and results: It was a descriptive study with an analytical purpose from May 2022 to August 2022 carried out in 8 districts of the city of N'Djamena. Wastewater samples were collected and analyzed using standard food microbiology methods. The detection of antibiotic residues was done by the premiTest which is a qualitative detection tool. A total of 42 wastewater samples were taken in the various districts of the capital. The prevalence of antibiotic residues obtained was variable (50 to 100%) from a district to other. It was 100% in the 6th district, 83% in the 8th district, 58% in the 7th district and 50% in the 10th, 1st, 2nd, 3rd and 9th districts of the city of Ndjamena respectively. Conclusion: The prevalence of antibiotic residues detected in the water environment reflects the poor management and use of antibiotics by human and veterinary health professionals in the city of N'Djamena. In this regard, the effluents generated by hospital and veterinary activities present a real danger for humans, animals and the environment, given the nature and importance of the specific substances they contain and because of their discharge. In the same way as conventional urban waste, into the communal sewerage system without prior treatment. The Ministry of Public Health and Prevention as well as the Ministry of Livestock and Animal Production must advocate to oblige officials at different levels to prohibit the discharge of drug residues into the environment of rational wastewater treatment in order to avoid bioresistance mechanisms in Chad.
{"title":"Identification of the presence of antibiotic residues in the water environment in Ndjamena, Chad","authors":"DJASBEYE Mounpor, Ban-Bo Bebanto Antipas, GANDOLO BONGO Naré Richard, NADLAOU Bessimbaye, NAIBI KEITOYO Amedé, RAHILA LOUM Ghazida, NAÏM Saturnin, HALIME HISSEIN Hangata","doi":"10.53771/ijlsra.2023.4.2.0060","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0060","url":null,"abstract":"Objective: The objective of this study is to determine the presence of antibiotic residues in the water environment. Methodology and results: It was a descriptive study with an analytical purpose from May 2022 to August 2022 carried out in 8 districts of the city of N'Djamena. Wastewater samples were collected and analyzed using standard food microbiology methods. The detection of antibiotic residues was done by the premiTest which is a qualitative detection tool. A total of 42 wastewater samples were taken in the various districts of the capital. The prevalence of antibiotic residues obtained was variable (50 to 100%) from a district to other. It was 100% in the 6th district, 83% in the 8th district, 58% in the 7th district and 50% in the 10th, 1st, 2nd, 3rd and 9th districts of the city of Ndjamena respectively. Conclusion: The prevalence of antibiotic residues detected in the water environment reflects the poor management and use of antibiotics by human and veterinary health professionals in the city of N'Djamena. In this regard, the effluents generated by hospital and veterinary activities present a real danger for humans, animals and the environment, given the nature and importance of the specific substances they contain and because of their discharge. In the same way as conventional urban waste, into the communal sewerage system without prior treatment. The Ministry of Public Health and Prevention as well as the Ministry of Livestock and Animal Production must advocate to oblige officials at different levels to prohibit the discharge of drug residues into the environment of rational wastewater treatment in order to avoid bioresistance mechanisms in Chad.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88077729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Trigonella foenum-graecum is medicinal plant of family Fabaceae, consists of bitter principles and traditionally used in treatment of diabetes and hepatoprotective. To mask its bitter taste, it could be formulated in honey based oral formulations like oxymel. Honey, as a saturated solution of various sugars, as per Ayurvedic system of medicine, could be consumed along with drug. This research attempt was aimed towards aqueous extraction of fenugreek seeds; formulation of oxymel by addition to honey and evaluation for different parameters. Oxymel was formulated as per procedure mentioned in United State Pharmacopeia for squill oxymel; and evaluated for pharmaceutical parameters those applied for oral syrups. Results: The oxymel formulated was pale brownish with agreeable odour and sweet taste. It was pourable with viscosity of 80 CP measured at 100 rpm while density was found to be 1.47 g/cm³. There was also ease in cap opening of its container, also no crystallization of honey was observed. Its trigonelline content was found to be 3.6 µg/ml. Conclusion: Alkaloids of fenugreek have significant pharmacological activities in human being, if administered orally. To mask their bitter taste and facilitate their increase in absorption, Trigonella foenum-graecum can successfully be formulated in honey based oral formulation of oxymel.
{"title":"Formulation and evaluation of oxymel containing fenugreek extract","authors":"Deepa Sarvan Mudaliyar, Sanika Datta Chavan, Soni Ashok Kushwaha, Rudra prasadrao Eppili, Shivani Bharat Khaladkar, Shriniwas Pramod Patil","doi":"10.53771/ijlsra.2023.4.2.0061","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0061","url":null,"abstract":"Introduction: Trigonella foenum-graecum is medicinal plant of family Fabaceae, consists of bitter principles and traditionally used in treatment of diabetes and hepatoprotective. To mask its bitter taste, it could be formulated in honey based oral formulations like oxymel. Honey, as a saturated solution of various sugars, as per Ayurvedic system of medicine, could be consumed along with drug. This research attempt was aimed towards aqueous extraction of fenugreek seeds; formulation of oxymel by addition to honey and evaluation for different parameters. Oxymel was formulated as per procedure mentioned in United State Pharmacopeia for squill oxymel; and evaluated for pharmaceutical parameters those applied for oral syrups. Results: The oxymel formulated was pale brownish with agreeable odour and sweet taste. It was pourable with viscosity of 80 CP measured at 100 rpm while density was found to be 1.47 g/cm³. There was also ease in cap opening of its container, also no crystallization of honey was observed. Its trigonelline content was found to be 3.6 µg/ml. Conclusion: Alkaloids of fenugreek have significant pharmacological activities in human being, if administered orally. To mask their bitter taste and facilitate their increase in absorption, Trigonella foenum-graecum can successfully be formulated in honey based oral formulation of oxymel.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85888889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.53771/ijlsra.2023.4.2.0063
Wahyudi Arianto, Wiryono, Guswarni Anwar
Amorphophallus titanum (Becc.) Becc. Ex Arcang), known as Titan Arum, is the only plant that has the highest inflorescence (1.6 m – 2.5 m) in the world. This species is classified as an endemic plant since it only found in forest areas on the island of Sumatra. According to the IUCN Red List of Threatened Plants the 2021 edition, A. titanum is Endangered (EN). The problem faced by A. titanum at this time is the habitat destruction, due to area conversion. The research on the ecological aspects of A. titanum includes population conditions, plant structure and composition, distribution patterns, soil, and climate data. was conducted in the Boven Lais Protected Forest, North Bengkulu Regency, Bengkulu Province. The vegetation analysis method were used to obtain data on the plant structure and composition of the vegetation (importance index) of A. titanum, and the habitat's abiotic (physical conditions). Determining the plant's distribution (spatial distribution) using the Morisita Spread Index method. The results showed that the population of A. titanum in the research area was 20 individuals, dominated by tillers with petiole diameters ranging from 0-5 cm. The entire population was found in the vegetative phase. The distribution pattern of A. titanum was clustered. The structure and composition of the vegetation in the A titanum habitat comprises 25 species belonging to 18 families. The tree-level vegetation was dominated by Elateriospermum tapos, the pole level was dominated by Ficus hispida L.f., and the seedling-level vegetation was dominated by Selaginella plana (Desv. ex Poir.) The soil type in the A. titanum habitat was red-yellow podzolic with sandy clay loam texture, acid soil with a pH of 4.79, medium N (nitrogen) content (0.33%), high C (carbon) content (3.7%) and very low P (phosphorus) content and high CEC.. The habitat was at an altitude of 433 m asl -459 m above sea level, with a slope of 45-60 degrees. Generally, the location where the A. titanum grew twas in a steep area. The average humidity in the habitat was 92.87%, the average light intensity was 647.19 lux, and the average temperature was 23.09oC
{"title":"Ecological study of titan arum [Amorphophallus titanum (Becc.) Becc. Ex arcang] in BOVEN LAIS protected forest, north Bengkulu regency","authors":"Wahyudi Arianto, Wiryono, Guswarni Anwar","doi":"10.53771/ijlsra.2023.4.2.0063","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0063","url":null,"abstract":"Amorphophallus titanum (Becc.) Becc. Ex Arcang), known as Titan Arum, is the only plant that has the highest inflorescence (1.6 m – 2.5 m) in the world. This species is classified as an endemic plant since it only found in forest areas on the island of Sumatra. According to the IUCN Red List of Threatened Plants the 2021 edition, A. titanum is Endangered (EN). The problem faced by A. titanum at this time is the habitat destruction, due to area conversion. The research on the ecological aspects of A. titanum includes population conditions, plant structure and composition, distribution patterns, soil, and climate data. was conducted in the Boven Lais Protected Forest, North Bengkulu Regency, Bengkulu Province. The vegetation analysis method were used to obtain data on the plant structure and composition of the vegetation (importance index) of A. titanum, and the habitat's abiotic (physical conditions). Determining the plant's distribution (spatial distribution) using the Morisita Spread Index method. The results showed that the population of A. titanum in the research area was 20 individuals, dominated by tillers with petiole diameters ranging from 0-5 cm. The entire population was found in the vegetative phase. The distribution pattern of A. titanum was clustered. The structure and composition of the vegetation in the A titanum habitat comprises 25 species belonging to 18 families. The tree-level vegetation was dominated by Elateriospermum tapos, the pole level was dominated by Ficus hispida L.f., and the seedling-level vegetation was dominated by Selaginella plana (Desv. ex Poir.) The soil type in the A. titanum habitat was red-yellow podzolic with sandy clay loam texture, acid soil with a pH of 4.79, medium N (nitrogen) content (0.33%), high C (carbon) content (3.7%) and very low P (phosphorus) content and high CEC.. The habitat was at an altitude of 433 m asl -459 m above sea level, with a slope of 45-60 degrees. Generally, the location where the A. titanum grew twas in a steep area. The average humidity in the habitat was 92.87%, the average light intensity was 647.19 lux, and the average temperature was 23.09oC","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73326802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-30DOI: 10.53771/ijlsra.2023.4.2.0059
Souad Youssouf Kani Elmi, Maad Nasser Mohamed, Houssein Yonis Arreh, Mohamed Ali Mohamed
Background: Tuberculosis (TB) remains a significant public health issue, and Djibouti is still one of the nations with a high TB burden, with a forecasted incidence rate of 224 cases per 100,000 people in 2020. Objectives: To compare the Ziehl-Neelsen (ZN) stain direct smear microscopy with the GeneXpert (Xpert MTB/RIF assay) as the gold standard for diagnosing patients with suspected pulmonary tuberculosis (PTB). Material and method: A health facility-based cross-sectional study was conducted on hospitalized patients at Peltier General Hospital from March to July 2022. A total of 153 samples (including bronchoalveolar lavage (BAL) and sputum) collected from presumptive TB patients were tested. Results: Out of the 153 samples analyzed by GeneXpert and ZN smear microscopy, 29 (19.0%) were detected by GeneXpert and 23 (15.0%) were positive by ZN smear microscopy. ZN smear microscopy had sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) that were 79.31%, 100%, 100%, and 95.38%, respectively. Conclusion: This study concluded that ZN smear had a slightly poor sensitivity for determining the presence of PTB; consequently, we continue to advise GeneXpert testing whenever it is possible to prevent prolonged morbidity in those affected and to prevent the direct as well as indirect expenses of missing the diagnosis of smear-negative PTB.
{"title":"Concordance between microscopic and molecular detection of Mycobacterium tuberculosis in hospitalized patients with suspected pulmonary tuberculosis in Peltier General Hospital, Djibouti","authors":"Souad Youssouf Kani Elmi, Maad Nasser Mohamed, Houssein Yonis Arreh, Mohamed Ali Mohamed","doi":"10.53771/ijlsra.2023.4.2.0059","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0059","url":null,"abstract":"Background: Tuberculosis (TB) remains a significant public health issue, and Djibouti is still one of the nations with a high TB burden, with a forecasted incidence rate of 224 cases per 100,000 people in 2020. Objectives: To compare the Ziehl-Neelsen (ZN) stain direct smear microscopy with the GeneXpert (Xpert MTB/RIF assay) as the gold standard for diagnosing patients with suspected pulmonary tuberculosis (PTB). Material and method: A health facility-based cross-sectional study was conducted on hospitalized patients at Peltier General Hospital from March to July 2022. A total of 153 samples (including bronchoalveolar lavage (BAL) and sputum) collected from presumptive TB patients were tested. Results: Out of the 153 samples analyzed by GeneXpert and ZN smear microscopy, 29 (19.0%) were detected by GeneXpert and 23 (15.0%) were positive by ZN smear microscopy. ZN smear microscopy had sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) that were 79.31%, 100%, 100%, and 95.38%, respectively. Conclusion: This study concluded that ZN smear had a slightly poor sensitivity for determining the presence of PTB; consequently, we continue to advise GeneXpert testing whenever it is possible to prevent prolonged morbidity in those affected and to prevent the direct as well as indirect expenses of missing the diagnosis of smear-negative PTB.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88260188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-30DOI: 10.53771/ijlsra.2023.4.2.0052
Siska Citra Amalia, Nyilo Purnami, Rosa Falerina, Nugroho Suharsono
Introduction: Sudden Sensorineural Hearing Loss (SSNHL) is a newly revealed clinical manifestation in COVID-19 patients. This is because corona virus is thought to cause auditory neuropathy spectrum disorders, inflammation, hypoxia due to erythrocyte deoxygenation, ischemia due to vascular occlusion, and immunological reactions that induce cellular stress pathways in peripheral to central auditory organs. Case: A case of SSNHL in patient who were confirmed positive for PCR swab. A 66-year-old man with severe COVID-19, with hypertension and DM, had moderate right SNHL, left severe SNHL, when the PCR swab result was negative. Therapy received: methylcobalamin, gingkobiloba, HBOT, and the hearing was improved. Conclusion: SSNHL was obtained in COVID-19 patient.
{"title":"Sudden sensorineural hearing loss in COVID-19 patient with hearing improvement","authors":"Siska Citra Amalia, Nyilo Purnami, Rosa Falerina, Nugroho Suharsono","doi":"10.53771/ijlsra.2023.4.2.0052","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0052","url":null,"abstract":"Introduction: Sudden Sensorineural Hearing Loss (SSNHL) is a newly revealed clinical manifestation in COVID-19 patients. This is because corona virus is thought to cause auditory neuropathy spectrum disorders, inflammation, hypoxia due to erythrocyte deoxygenation, ischemia due to vascular occlusion, and immunological reactions that induce cellular stress pathways in peripheral to central auditory organs. Case: A case of SSNHL in patient who were confirmed positive for PCR swab. A 66-year-old man with severe COVID-19, with hypertension and DM, had moderate right SNHL, left severe SNHL, when the PCR swab result was negative. Therapy received: methylcobalamin, gingkobiloba, HBOT, and the hearing was improved. Conclusion: SSNHL was obtained in COVID-19 patient.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87876157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-30DOI: 10.53771/ijlsra.2023.4.2.0062
Patang
Background: This study aims to determine the possibility of cultivating Eucheuma cottonii seaweed based on plankton aspects around Pancana Beach, Barru Regency, Indonesia. Materials and Methods: The study was divided into 3 observation stations (ST) based on the characteristics of each location. Data was collected and analyzed by descriptive analysis. Results: The results showed that based on the plankton aspect, the research location was still suitable for the cultivation of seaweed of the type Eucheuma cottonii when viewed from the aspects of plankton abundance, diversity, uniformity and dominance. Conclusions: All study sites have suitable plankton abundance, diversity and uniformity which can support the growth and survival of Eucheuma cottonii, and no plankton dominates in these waters.
{"title":"The study of plankton parameters for the cultivation of Eucheuma cottonii seaweed around Pancana Beach, Barru Regency, Indonesia","authors":"Patang","doi":"10.53771/ijlsra.2023.4.2.0062","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0062","url":null,"abstract":"Background: This study aims to determine the possibility of cultivating Eucheuma cottonii seaweed based on plankton aspects around Pancana Beach, Barru Regency, Indonesia. Materials and Methods: The study was divided into 3 observation stations (ST) based on the characteristics of each location. Data was collected and analyzed by descriptive analysis. Results: The results showed that based on the plankton aspect, the research location was still suitable for the cultivation of seaweed of the type Eucheuma cottonii when viewed from the aspects of plankton abundance, diversity, uniformity and dominance. Conclusions: All study sites have suitable plankton abundance, diversity and uniformity which can support the growth and survival of Eucheuma cottonii, and no plankton dominates in these waters.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81691093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.53771/ijlsra.2023.4.2.0049
Shyamsundar Sampat Jagtap, Yogita Hiralal Thite
Background: Agnikarma is regarded as the best of the Anushastras because of its quick results and long lasting effects. It is said that there is no recurrence of disease when treated with Agnikarma and also diseases which are not treated with medicine, shastras and kshar are best treated with agnikarma. For (apunarbhav) non recurrence of disease Agnikarma is advised. Ayurvedic classics stated the use of agnikarma in the management of various kshudraroga , Kadar (corn) is one among them. The pathophysiology of kadar is caused by vitiated meda and rakta by injury to foot which in turn leads to gland like hard skin texture at foot known as Kadar( corn). In present case study efficacy of agnikarma in the management of Kadar as stated in ayurvedic texts is evaluated. Methodology: Agnikarma was done with loh shalaka with exision of Kadar followed by application of oil with 3 settings in which each setting is for 3 days. Proper follow up was taken for about six months in order to observe for any recurrence. Observation: It was observed that within a month the complete skin of foot healed without leaving any sign of slough discharge. The patient observed after 1 year there is no recurrence of corn again at that particular site. Conclusion: It can be concluded that Agnikarma is not only a successful tratment in treating corn (kadar ) but also there is no recurrence again.
{"title":"Agnikarma treatment in the management of Corn (Kadar): A case report","authors":"Shyamsundar Sampat Jagtap, Yogita Hiralal Thite","doi":"10.53771/ijlsra.2023.4.2.0049","DOIUrl":"https://doi.org/10.53771/ijlsra.2023.4.2.0049","url":null,"abstract":"Background: Agnikarma is regarded as the best of the Anushastras because of its quick results and long lasting effects. It is said that there is no recurrence of disease when treated with Agnikarma and also diseases which are not treated with medicine, shastras and kshar are best treated with agnikarma. For (apunarbhav) non recurrence of disease Agnikarma is advised. Ayurvedic classics stated the use of agnikarma in the management of various kshudraroga , Kadar (corn) is one among them. The pathophysiology of kadar is caused by vitiated meda and rakta by injury to foot which in turn leads to gland like hard skin texture at foot known as Kadar( corn). In present case study efficacy of agnikarma in the management of Kadar as stated in ayurvedic texts is evaluated. Methodology: Agnikarma was done with loh shalaka with exision of Kadar followed by application of oil with 3 settings in which each setting is for 3 days. Proper follow up was taken for about six months in order to observe for any recurrence. Observation: It was observed that within a month the complete skin of foot healed without leaving any sign of slough discharge. The patient observed after 1 year there is no recurrence of corn again at that particular site. Conclusion: It can be concluded that Agnikarma is not only a successful tratment in treating corn (kadar ) but also there is no recurrence again.","PeriodicalId":14144,"journal":{"name":"International Journal of Life Science Research Archive","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83233674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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