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Newborn screening by enzyme immunoassay using dry blood spot for diagnosis of metabolic disorders 干血点酶免疫法筛查新生儿代谢性疾病的研究
Pub Date : 2021-01-01 DOI: 10.5455/ijmsph.2021.04032202119062021
Fahima H, D. S, Chindhiha S, S. Vincy, Chandrasekar M, S. K.
Background: Newborn screening (NBS) is the test used to diagnosis the metabolic and other disorders within 72 h of birth. The early identification of the disorder helps in early treatment which prevents neonates from life-threatening health problem, mental retardation, and serious lifelong disabilities. Objectives: Universal NBS using heel-prick dried blood spot (DBS) samples has become an integral part of public health system in developed countries. There are about 99.9% of newborns that are screened every year in western countries. Whereas, in India the less 1% of newborns are screened due to the ignorance and not knowing the importance of NBS. Very few states in India had started the program in government. Awareness among the professionals and public about the NBS has to be created and extended. Materials and Methods: The Newborn DBS samples were received from Government Vellore Medical College Hospital, Government Hospitals at Tirupattur, Gudiyatham and 104 primary health centers. Samples should be collected within 72 h from the newborn. Screening of human thyroid-stimulating hormones, 17-OHP, glucose-6-phosphate dehydrogenase, Galactose, and IRT are done using the Enzyme Immunoassay (EIA) method using their respective conjugate, Conjugate Diluent, Substrate solution TMB Chromogen, washing solution 10 ×, 1 × 50 ml Stopping solution and measured using micro plate photometer. Point of care testing (POCT) requires only 1 drop (10 μL) of blood from the pricked heel of the baby, and it can be performed 5–10 min at bedside. Results: NBS is done using the EIA method which reports between 8 and 12 days. Comparing point of care (POCT) with EIA, the results of POCT are compatible and satisfactory and it completes in 5 days. Conclusion: The proper implementation of “point of care” testing will help to identify the positive cases early and prevents the baby from permanent disability.
背景:新生儿筛查(NBS)是用于诊断出生72小时内代谢和其他疾病的检查。这种疾病的早期识别有助于早期治疗,从而防止新生儿出现危及生命的健康问题、智力迟钝和严重的终身残疾。目的:采用足跟刺干血斑(DBS)样本进行全民血检已成为发达国家公共卫生系统的重要组成部分。在西方国家,每年约有99.9%的新生儿接受筛查。然而,在印度,由于无知和不知道国家统计局的重要性,只有不到1%的新生儿接受了筛查。印度很少有邦在政府中启动了这个项目。专业人士和公众对国家统计局的认识必须建立和扩大。材料与方法:新生儿DBS样本来自政府Vellore医学院医院、Tirupattur、Gudiyatham的政府医院和104个初级卫生中心。应在72小时内从新生儿身上采集样本。人促甲状腺激素、17-OHP、葡萄糖-6-磷酸脱氢酶、半乳糖和IRT的筛选采用酶免疫分析法(EIA),分别使用它们各自的偶联物、偶联稀释剂、底物溶液TMB显色剂、洗涤液10 ×、停止液1 × 50 ml进行筛选,并用微板光度计进行测定。POCT (Point of care testing)只需从婴儿刺破的足跟处滴1滴(10 μL)血,可在床边进行5 ~ 10分钟。结果:国家统计局采用EIA方法,报告时间为8 - 12天。点疗(POCT)与环评(EIA)比较,结果一致,满意,在5天内完成。结论:正确实施“护理点”检测有助于早期发现阳性病例,防止婴儿终身残疾。
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引用次数: 0
Assessment of different teaching modalities in gastroenterology module on students' satisfaction 胃肠病学模块不同教学方式对学生满意度的评价
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2021.03027202123042021
T. Ghamdi
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引用次数: 0
Primary fallopian tube carcinoma: A rare case report 原发性输卵管癌1例报告
Pub Date : 2021-01-01 DOI: 10.5455/ijmsph.2021.06051202119062021
Aakriti Garg, S. Mukherjee, S. Mukherjee, Pragya Mishra
Carcinoma of the fallopian tube accounts for 0.3% of all cancers of the female genital tract1. There has been a rapidly increasing body of evidence supporting the fallopian tube as the site of origin of high grade serous ovarian cancer. This case report describes 37 years old female with known case of hypothyroidism who presented with pain abdomen which was diffuse, progressive. On examination, there was hard irregular mass around umbilicus. She was then subjected to further investigations and was taken for staging laparotomy. During surgery, specimens were sent for histopathological examination at Rohilkhand Medical College and Hospital, Bareilly. Histopathological examination revealed the diagnosis of primary fallopian tube carcinoma (PFTC). This case is unique since we started it as a case of bilateral ovarian mass but histology revealed it to be a PFTC.
输卵管癌占女性生殖道所有癌症的0.3%。越来越多的证据支持输卵管是高级别浆液性卵巢癌的发病部位。本病例报告描述了37岁女性甲状腺功能减退症的已知病例,她表现为弥漫性进行性腹部疼痛。检查见脐周围有不规则硬块。随后,她接受了进一步的检查,并被分阶段剖腹手术。手术期间,标本被送到巴雷利的罗希尔坎德医学院和医院进行组织病理学检查。组织病理学检查诊断为原发性输卵管癌(PFTC)。这个病例是独特的,因为我们开始时它是一个双侧卵巢肿块,但组织学显示它是一个PFTC。
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引用次数: 0
Awareness on mental illness and delayed in seeking health services among members of psychiatric patient 精神病患者成员对精神疾病的认识和寻求保健服务的延迟
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2021.02017202117032021
Radha Aryal, K. Pun, Deepak Belbase, M. Panthi
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引用次数: 0
Study determining factors related to delayed diagnosis and late-stage presentation in patients of carcinoma of cervix in tertiary care hospital 三级医院宫颈癌患者延迟诊断和晚期表现的影响因素研究
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2021.03040202123042021
A. Priya, D. K. Pal, P. Bhatia
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引用次数: 0
Assessment of risk factor, awareness, and educational intervention in various types of cancers 不同类型癌症的风险因素评估、意识和教育干预
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2020.12189202008012021
A. Sreedevi, T SivaKala, P KrishnaBharadwaj
Background: Despite promising medical advancements and treatment, cancer is still a significant threat to our society. Hence, this study is undertaken to evade severe public health issues related to cancers. Objectives: The aim of the study was to increase the awareness among the general population in field practice areas about risk factors of prevalent cancers and its prevention with the following objectives: (1) To determine the types of highly prevalent cancers among the patients attending Government General Hospital (GGH), Kurnool. (2) To know the public awareness about risk factors and prevention of cancers. (3) To educate the population about risk factors of prevalent cancers and their prevention. Materials and Methods: Study design: Information collected from January 1, 2014, to April 30, 2014, from the Department of Radiotherapy, GGH, Kurnool, to reveal the district’s morbidity pattern, the predominant type of cancers, followed by a community-based cross-sectional study to assess population awareness. Permissions from Institutional Ethics Committee and Head of the Department of Radiotherapy was obtained before starting of the study. Informed consent was taken from the study participants in the community. Statistics: Data analyzed using Microsoft Excel 2007, presented results in the form of percentages and proportions. Results: The predominant types of cancers identified were cervical, breast, and lung cancers based on information collected from 81 registered cases. The community-based cross-sectional study revealed meager public awareness about cervical cancer, the importance of Pap smear testing, and self-breast examination in both rural and urban field practice areas. Conclusions: Educational intervention was conducted to increase public awareness about cervical cancer, the importance of Pap smear testing, and self-breast examination.
背景:尽管医学进步和治疗有希望,癌症仍然是我们社会的一个重大威胁。因此,进行这项研究是为了避免与癌症有关的严重公共卫生问题。目的:本研究的目的是提高现场实践地区普通民众对流行癌症危险因素及其预防的认识,目的如下:(1)确定在库尔努尔政府总医院(GGH)就诊的患者中高流行癌症的类型。(2)了解公众对癌症危险因素及预防的认识。(3)教育民众了解流行癌症的危险因素及其预防。材料与方法:研究设计:收集2014年1月1日至2014年4月30日来自Kurnool GGH放射治疗科的信息,以揭示该地区的发病率模式和主要癌症类型,然后进行基于社区的横断面研究,以评估人群的认知。在研究开始前获得了机构伦理委员会和放疗系主任的许可。知情同意书来自社区的研究参与者。统计:使用Microsoft Excel 2007对数据进行分析,以百分比和比例的形式呈现结果。结果:根据收集的81例登记病例的信息,确定的主要癌症类型是宫颈癌、乳腺癌和肺癌。这项以社区为基础的横断面研究显示,在农村和城市现场实践地区,公众对宫颈癌、巴氏涂片检查和自我乳房检查的重要性认识不足。结论:通过教育干预,提高公众对宫颈癌的认识、巴氏涂片检查的重要性和自我乳房检查的重要性。
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引用次数: 0
Global health and wellness initiative of world noncommunicable disease federation – Play, laugh, and grow (Indian version: Khelo, Hasso Aur Hasao, Badho Aur Badhao, India) 世界非传染性疾病联合会全球健康和保健倡议——玩耍、欢笑和成长(印度版本:Khelo, Hasso Aur Hasao, Badho Aur Badhao,印度)
Pub Date : 2021-01-01 DOI: 10.4103/JNCD.JNCD_14_21
J. Thakur
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引用次数: 0
Prevalence and characteristics of impaired awareness of hypoglycemia in King Fahad Medical City, Saudi Arabia 沙特阿拉伯法赫德国王医疗城低血糖认知障碍的患病率和特点
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2021.03022202117032021
Abdulmalik M. Aloriney
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引用次数: 0
Home management of mild-moderate coronavirus disease-19 patients in low-resource countries: Reducing the burden on hospitals and a guide to clinical excellence 资源匮乏国家轻中度冠状病毒病19例患者的家庭管理:减轻医院负担和临床卓越指南
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2021.02015202119032021
Ballah Abubakar, Y. Jibrin, D. Jacob, Maigari Ibrahim, Ibrahim Salim, Suleiman Lawan
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引用次数: 1
Compliance to iron and folic acid supplements among the pregnant women of the rural field practice area of a medical college in Central Karnataka 卡纳塔克邦中部一所医学院农村实习区的孕妇对铁和叶酸补充剂的依从性
Pub Date : 2021-01-01 DOI: 10.5455/ijmsph.2021.06052202121062021
N. G, A. Bullappa, Prakash Kengnal
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引用次数: 1
期刊
International Journal of Medical Science and Public Health
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