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Knowledge, attitudes, and willingness of adolescents towards coronavirus disease 2019 vaccine in Bangkok, Thailand 泰国曼谷青少年对2019冠状病毒病疫苗的知识、态度和意愿
Pub Date : 2021-01-01 DOI: 10.5455/ijmsph.2021.07075202111082021
Manassanun Wirunpan
Background: The outbreak of coronavirus disease 2019 (COVID-19) was declared by the World Health Organization (WHO) as a COVID-19 pandemic on March 11, 2020. Therefore, the availability of vaccines will help develop immunity and protect people from this pandemic. The present systematic study examined knowledge, attitudes, and willingness of adolescents towards COVID-19 vaccine in Bangkok, Thailand. Objectives: The objective of the study was to evaluate the knowledge, attitudes, and willingness toward COVID-19 vaccine of key stage 4A-5 students at Satit Prasarnmit International Programme in Bangkok towards COVID-19 vaccine. Materials and Methods: The study was conducted using an online questionnaire. A total of 136 students participated. Knowledge, attitudes, and willingness of adolescents toward the COVID-19 vaccine were assessed. Differences between outcomes and socio-demographic characteristics of participants were analyzed through independent t-tests and the ANOVA. The level of willingness to vaccinate against COVID-19 was analyzed by a generalized linear model. Results: Students revealed moderate knowledge about COVID-19, correctly answering 11.08 out of 15 points (SD = 1.74), a low level of attitudes toward COVID-19 vaccine 8.49 out of 15 points (SD = 2.51), and low level of willingness to vaccinate against COVID-19 vaccine 2.29 out of 5 points (SD = 1.26), in total of 35 points (28 questions). There are statistically significant positive correlations shown between attitude towards COVID-19 vaccine and the level of willingness to vaccinate against COVID-19 vaccine (I2 = 0.384, P < 0.01%). Conclusion: This study revealed students in Satit Prasarnmit International Programme had moderate knowledge towards COVID-19, negative attitudes toward COVID-19 vaccine and low willingness to vaccinate against COVID-19. Furthermore, it indicates that there is a casual relationship between attitudes toward COVID-19 vaccine and the willingness of individuals to be vaccinated against COVID-19 vaccine. Thus, attitude toward COVID-19 vaccine acts as a major predictive factor toward the willingness to vaccinate against COVID-19 vaccine. Therefore, to increase peopleA's willingness to be vaccinated against COVID-19 vaccine, it is necessary to increase peopleA's attitude toward COVID-19 vaccine.
背景:2020年3月11日,世界卫生组织(WHO)宣布2019冠状病毒病(COVID-19)爆发为COVID-19大流行。因此,疫苗的供应将有助于建立免疫力并保护人们免受这次大流行的影响。本系统研究调查了泰国曼谷青少年对COVID-19疫苗的知识、态度和意愿。目的:本研究的目的是评估曼谷Satit Prasarnmit国际项目关键4A-5期学生对COVID-19疫苗的知识、态度和意愿。材料与方法:本研究采用在线问卷方式进行。共有136名学生参加。评估青少年对COVID-19疫苗的知识、态度和意愿。通过独立t检验和方差分析分析结果与参与者社会人口学特征之间的差异。采用广义线性模型分析COVID-19疫苗接种意愿水平。结果:学生对新冠肺炎的了解程度一般,正确回答了11.08分(15分)(SD = 1.74),对新冠肺炎疫苗的态度较低,为8.49分(15分)(SD = 2.51),对新冠肺炎疫苗接种的意愿较低,为2.29分(5分)(SD = 1.26),共35分(28题)。对新冠肺炎疫苗态度与疫苗接种意愿呈显著正相关(I2 = 0.384, P < 0.01%)。结论:本研究显示,Satit Prasarnmit国际项目学生对COVID-19的认知程度一般,对COVID-19疫苗的态度消极,接种意愿低。此外,这表明对COVID-19疫苗的态度与个人接种COVID-19疫苗的意愿之间存在因果关系。因此,对新冠病毒疫苗的态度是影响新冠病毒疫苗接种意愿的主要预测因素。因此,要提高人们接种COVID-19疫苗的意愿,需要提高人们对COVID-19疫苗的态度。
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引用次数: 1
Impact of chronic obstructive pulmonary disease on severity and outcomes in COVID-19 patients: A systematic review 慢性阻塞性肺疾病对COVID-19患者严重程度和结局的影响:一项系统综述
Pub Date : 2021-01-01 DOI: 10.4103/JNCD.JNCD_7_21
A. Aggarwal, R. Agarwal, S. Dhooria, K. Prasad, I. Sehgal, V. Muthu
We conducted this systematic review to evaluate whether comorbid chronic obstructive pulmonary disease (COPD) increases the risk of severe disease and adverse outcomes among patients with coronavirus disease (COVID-19). We queried the PubMed and Embase databases for studies indexed till December 2020. We included studies that provided data on severe disease, hospitalization, intensive care unit (ICU) care, need for mechanical ventilation, or mortality among COVID-19 patients with and without COPD. We calculated the relative risk (RR) for each reported outcome of interest from each study and used a random-effects model to summarize our data. We retrieved 997 citations and included 110 studies published in 2020, in our review. Most publications reported the data retrieved from electronic records of retrospective patient cohorts. Only 27 studies were judged to be of high quality. COPD patients with COVID-19 had a significantly higher risk of severe disease (summary RR 2.44, 95% confidence interval [CI] 1.93-3.09), hospitalization (summary RR 1.91, 95% CI 1.70-2.14), ICU admission (summary RR 1.81, 95% CI 1.35-2.43), mechanical ventilation (summary RR 1.75, 95% CI 1.35-2.28), and mortality (summary RR 2.40, 95% CI 1.93-2.51), as compared to COVID-19 patients without COPD. All analyses showed significant between-study heterogeneity. We conclude that comorbid COPD significantly increases the risk of severe disease and adverse outcomes among COVID-19 patients.
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引用次数: 2
Periocular anthropometric measurements analysis in ethnic adults of Vindhya region 温迪亚地区少数民族成人眼周人体测量分析
Pub Date : 2021-01-01 DOI: 10.5455/IJMSPH.2021.09148202021052021
Chandraprabha Choudhary, P. Khanwalkar, M. Mishra, Sujata Lakhtakia
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引用次数: 1
Fungal infection in surgical pathology - Our institutional experience 外科病理中的真菌感染-我们的机构经验
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.07216201912012020
Khushbu P. Shah, M. Patel
Background: Fungal infection has a worldwide prevalence and it affects almost all age groups and both the sexes. Due to neoteric treatment modalities nowadays, people are enjoying longevity of life. However, on the other hand, immune status is compromised that has resulted in increased prevalence of fungal infection in society. Fungi reported by surgical pathologist, either incidentally or in clinically suspicious cases, greatly improve morbidity and outcome of the patients. Objective: The objective of this study is to study the prevalence of fungal infection in surgical pathology tissue and frequency and spectrum-based analysis in relation to age, gender, and systemic involvement. Materials and Methods: Ethically approved retrospective observational secondary data analysis is done based on histomorphological and cytomorphological evaluation of 17 fungal cases diagnosed at the Department of Pathology, New Civil Hospital, Surat, from January 2015 to January 2017. Results: Out of 17 cases, most common fungus seen was Candida albicans mainly affecting gastrointestinal tract. Common age group affected was 41–60 years and few rare fungi, i.e., mucormycosis and tinea corporis were also reported. Conclusion: Distribution of fungi in tissue section in relation to frequency, age, sex, various organs, and its correlation with clinical symptoms is analyzed in our study and results are found to be yielding that provided outlook in the prevalence of infectious agent.
背景:真菌感染在世界范围内流行,它影响几乎所有年龄组和两性。由于现代的治疗方式,人们正在享受长寿。然而,另一方面,免疫状态受到损害,导致社会中真菌感染的患病率增加。外科病理学家报告的真菌,无论是偶然的还是临床可疑的病例,都大大提高了患者的发病率和预后。目的:本研究的目的是研究外科病理组织中真菌感染的患病率,以及与年龄、性别和全身累及相关的频率和频谱分析。材料与方法:对2015年1月至2017年1月在苏拉特新民建医院病理科诊断的17例真菌病例进行组织形态学和细胞形态学评价,进行回顾性观察性二次资料分析,经伦理批准。结果:17例中以白色念珠菌为主,主要累及胃肠道。常见年龄组为41 ~ 60岁,罕见真菌如毛霉病和体癣也有报道。结论:本研究分析了真菌在组织切片中的分布与频率、年龄、性别、各器官的关系及其与临床症状的相关性,为感染性病原体的流行提供了前景。
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引用次数: 1
Effectiveness of a “home care model” for oral cancer patients on the home care competency of their caregivers 口腔癌患者“家庭照护模式”对照护者家庭照护能力的影响
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.0101202007012020
Mahesh Kumar Bawliya, R. Sylvia, P. Mahala, Suman Kumar Choudhary
Background: Cancer can occur to everyone regardless of sex, age, culture, socioeconomic status, and geographical area. Various forms of cancer strike at different age, ethnic, gender groups with severity, and varying frequency. Objective: The study objectives were as follows: (1) To develop and implement a home care model on home care competency of caregivers and (2) to evaluate the effectiveness of home care model on home care competency of caregivers. Materials and Methods: For this study, a quantitative research approach was used to develop and implement a home care model on home care competency (knowledge and practice) of caregivers. A quasi-experimental one-group pre-test and post-test design was used in the study. The study was conducted in a selected hospital, Dehradun, Uttarakhand. Consecutive sampling technique was used to select the study subject. Data were collected from 40 caregivers of oral cancer patients using a structured knowledge questionnaire, structured self-report nutritional practice checklist, and structured observational wound care checklist. Results: The mean post-test practice scores and knowledge scores (18.75, 12.82, and 7.55) were higher than mean pre-test practice scores and knowledge scores (11.95, 8.85, and 4.23) which were found statistically significant at P < 0.05. The mean percentage area-wise distribution of knowledge regarding nutritional management at pre-test was 51% and wound care management was 55%, which was improved for both (81%) at post-test. No significant association was found between knowledge and practice except occupation. Minor correlation was found between post-test knowledge and post-test practice scores. Conclusion: It is concluded that home care competency program was found effective to improve the knowledge and practice of caregivers of oral cancer patients.
背景:癌症可能发生在每个人身上,不分性别、年龄、文化、社会经济地位和地理区域。不同年龄、不同种族、不同性别的人罹患各种形式的癌症,其严重程度和发生频率各不相同。目的:本研究的目的是:(1)建立和实施家庭护理模式对照顾者家庭护理能力的影响;(2)评估家庭护理模式对照顾者家庭护理能力的影响效果。材料与方法:本研究采用定量研究的方法,开发并实施了一个关于照顾者家庭护理能力(知识与实践)的家庭护理模型。本研究采用准实验的单组前测和后测设计。这项研究是在北阿坎德邦德拉敦一家选定的医院进行的。采用连续抽样方法选择研究对象。采用结构化知识问卷、结构化自我报告营养实践检查表和结构化观察性伤口护理检查表对40名口腔癌患者护理人员进行数据收集。结果:学生测验后实践得分和知识得分的平均值(18.75、12.82、7.55)高于测验前实践得分和知识得分的平均值(11.95、8.85、4.23),差异有统计学意义(P < 0.05)。测试前营养管理知识的平均百分比为51%,伤口护理管理知识的平均百分比为55%,测试后两者均有所改善(81%)。除职业外,知识与实践无显著相关。测试后知识与测试后实践得分之间存在较小的相关性。结论:家庭护理能力规划能有效提高口腔癌患者护理人员的知识和实践水平。
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引用次数: 0
Knowledge assessment of accredited social health activist and anganwadi workers about the Rashtriya Bal Swasthya Karyakram in rural area of District Kathua 经认证的社会卫生活动家和安干瓦迪工作人员对卡图瓦区农村地区Rashtriya Bal Swasthya Karyakram的知识评估
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.01015202017032020
Sonika Sangra, N. Choudhary, Akash Narangyal
Background: The Rashtriya Bal Swasthya Karyakram (RBSK) program is technically known as Child Health Screening and Early Intervention Services. The main purpose of the program is to detect and manage 4Ds which are prevalent in children. Objective: The objective of the study was to assess the knowledge of ASHA workers as well as anganwadi workers about the RBSK in rural area of District Kathua using semi-structured questionnaire. Materials and Methods: The present study was a cross-sectional descriptive study conducted in the zone Budhi which is a field practice area of the Department of Community Medicine, GMC Kathua. The zone consists of 24 villages with 18 ASHA workers and 35 anganwadi workers and one mobile RBSK team available at Community Health Center, Parole. After obtaining ethical clearance, all the ASHA workers and anganwadi workers were included in the study as they were willing to participate. Results: The present study revealed that majority of the workers were between the age group of 20–40 years. About 71.42% of the anganwadi workers were 12th pass and majority of the ASHA workers were 8th and 10th pass. Majority of the anganwadi workers received training related to RBSK program and knew about the benefits of the RBSK program. About 82.85% of the workers knew about the equipment used by RBSK team members for screening. Conclusion: Anganwadi workers and ASHAs need to be made aware of their perceptions and role in the program so that their efficiency is increased and the percentage of child morbidity and mortality can further be lowered.
背景:Rashtriya Bal Swasthya Karyakram (RBSK)项目在技术上被称为儿童健康筛查和早期干预服务。该计划的主要目的是检测和管理儿童中普遍存在的4Ds。目的:采用半结构式问卷法,对卡图瓦区农村地区ASHA工人和安干瓦地工人的RBSK知识进行评估。材料与方法:本研究为横断面描述性研究,在加德满都GMC社区医学部的野外实习区Budhi地区进行。该地区由24个村庄组成,有18名ASHA工作人员和35名anganwadi工作人员,在假释社区卫生中心有一个流动RBSK小组。在获得伦理许可后,所有ASHA员工和anganwadi员工都被纳入研究,因为他们愿意参与。结果:本研究发现,大多数工人年龄在20 - 40岁之间。约71.42%的anganwadi工人为12级合格,ASHA工人以8级和10级合格居多。大多数安干瓦迪工人接受过与RBSK计划相关的培训,并了解RBSK计划的好处。约82.85%的工人知道RBSK团队成员使用的筛查设备。结论:需要让Anganwadi工作人员和ASHAs意识到他们在项目中的观念和作用,从而提高他们的效率,进一步降低儿童发病率和死亡率。
{"title":"Knowledge assessment of accredited social health activist and anganwadi workers about the Rashtriya Bal Swasthya Karyakram in rural area of District Kathua","authors":"Sonika Sangra, N. Choudhary, Akash Narangyal","doi":"10.5455/ijmsph.2020.01015202017032020","DOIUrl":"https://doi.org/10.5455/ijmsph.2020.01015202017032020","url":null,"abstract":"Background: The Rashtriya Bal Swasthya Karyakram (RBSK) program is technically known as Child Health Screening and Early Intervention Services. The main purpose of the program is to detect and manage 4Ds which are prevalent in children. Objective: The objective of the study was to assess the knowledge of ASHA workers as well as anganwadi workers about the RBSK in rural area of District Kathua using semi-structured questionnaire. Materials and Methods: The present study was a cross-sectional descriptive study conducted in the zone Budhi which is a field practice area of the Department of Community Medicine, GMC Kathua. The zone consists of 24 villages with 18 ASHA workers and 35 anganwadi workers and one mobile RBSK team available at Community Health Center, Parole. After obtaining ethical clearance, all the ASHA workers and anganwadi workers were included in the study as they were willing to participate. Results: The present study revealed that majority of the workers were between the age group of 20–40 years. About 71.42% of the anganwadi workers were 12th pass and majority of the ASHA workers were 8th and 10th pass. Majority of the anganwadi workers received training related to RBSK program and knew about the benefits of the RBSK program. About 82.85% of the workers knew about the equipment used by RBSK team members for screening. Conclusion: Anganwadi workers and ASHAs need to be made aware of their perceptions and role in the program so that their efficiency is increased and the percentage of child morbidity and mortality can further be lowered.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"42 1","pages":"280-282"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73969979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Status of school health services in government and private schools: A community-based cross-sectional study from North India 公立学校和私立学校的学校保健服务状况:印度北部一项基于社区的横断面研究
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.10168202030102020
A. Ranga, J. Majra
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引用次数: 0
Knowledge, attitude, and practice of health-care ethics among doctors in Tamil Nadu - A cross-sectional study 泰米尔纳德邦医生保健伦理的知识、态度和实践——一项横断面研究
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.0506823052020
K. Karthikeyan, D. Kanagaraj, V. Karthikeyan, Sivasankaran Devandiran
Background: Proficiency in medical ethics is central to valuable patient care. The current medical education gives limited help in dealing with the ethical dilemmas. Objective: The objective of the study was to assess the knowledge, attitude, and practice of health-care ethics among doctors in Tamil Nadu. Materials and Methods: A questionnaire-based cross-sectional study covering all doctors on payroll (171) as on August 1, 2018, was carried out in August 2018 at Government Tiruvannamalai Medical College. A total of 165 doctors were contacted and 148 questionnaires were collected back. The pre-tested questionnaire comprised 44 questions. Approval from the Institutional Ethics Committee was obtained. SPSS version 22 was used to analyze data. Association between sociodemographic variables and attitude, practice of the doctors toward the health-care ethics was compared using Chi-square test. Results: About 87.8% of respondents were aware of the definition of health-care ethics. About 78.4% of respondents knew the duties of ethical committee. Books and journals were the source of knowledge for 66.2% of respondents. About 52% of the respondents preferred to consult their guide/head of department when they faced an ethical/legal issue. Nearly 60% were aware of existence of ethical committee. About 62.2% of the respondents had positive attitude toward health-care ethics. About 69% of the respondents had good practice of health-care ethics. Age group, sex, specialty, and duration of work experience had no significant association with attitude toward health-care ethics. Age group had significant correlation with practice while sex, specialty, and duration of work experience did not. Conclusion: Nine-tenth of respondents were aware of the definition of health-care ethics. Three-fourth was aware of duties of ethical committee. Nearly two-third of the respondents had positive attitude toward health-care ethics. More than two-third of the respondents had good practice of health-care ethics.
背景:精通医学伦理是有价值的病人护理的核心。当前的医学教育对处理伦理困境的帮助有限。目的:本研究的目的是评估泰米尔纳德邦医生的卫生保健伦理知识、态度和实践。材料与方法:一项基于问卷的横断面研究于2018年8月在Tiruvannamalai政府医学院进行,涵盖截至2018年8月1日所有在职医生(171名)。共联系165名医生,回收问卷148份。预测问卷包含44个问题。已获得机构伦理委员会的批准。采用SPSS version 22进行数据分析。采用卡方检验比较社会人口学变量与医生卫生伦理态度、实践的相关性。结果:87.8%的被调查者了解卫生保健伦理的定义。约78.4%的受访者知道伦理委员会的职责。66.2%的受访者认为书籍和期刊是知识的来源。约52%的受访者在遇到道德/法律问题时,倾向于咨询他们的导游/部门主管。近60%的人知道道德委员会的存在。62.2%的受访者对医疗卫生伦理持积极态度。约69%的应答者有良好的保健道德实践。年龄、性别、专业、工作经验与卫生保健伦理态度无显著相关。年龄与实习有显著的相关性,而性别、专业、工作时间与实习无显著的相关性。结论:十分之九的答复者知道保健伦理的定义。四分之三的人知道道德委员会的职责。近三分之二的受访者对卫生保健伦理持积极态度。超过三分之二的答复者有良好的保健道德实践。
{"title":"Knowledge, attitude, and practice of health-care ethics among doctors in Tamil Nadu - A cross-sectional study","authors":"K. Karthikeyan, D. Kanagaraj, V. Karthikeyan, Sivasankaran Devandiran","doi":"10.5455/ijmsph.2020.0506823052020","DOIUrl":"https://doi.org/10.5455/ijmsph.2020.0506823052020","url":null,"abstract":"Background: Proficiency in medical ethics is central to valuable patient care. The current medical education gives limited help in dealing with the ethical dilemmas. Objective: The objective of the study was to assess the knowledge, attitude, and practice of health-care ethics among doctors in Tamil Nadu. Materials and Methods: A questionnaire-based cross-sectional study covering all doctors on payroll (171) as on August 1, 2018, was carried out in August 2018 at Government Tiruvannamalai Medical College. A total of 165 doctors were contacted and 148 questionnaires were collected back. The pre-tested questionnaire comprised 44 questions. Approval from the Institutional Ethics Committee was obtained. SPSS version 22 was used to analyze data. Association between sociodemographic variables and attitude, practice of the doctors toward the health-care ethics was compared using Chi-square test. Results: About 87.8% of respondents were aware of the definition of health-care ethics. About 78.4% of respondents knew the duties of ethical committee. Books and journals were the source of knowledge for 66.2% of respondents. About 52% of the respondents preferred to consult their guide/head of department when they faced an ethical/legal issue. Nearly 60% were aware of existence of ethical committee. About 62.2% of the respondents had positive attitude toward health-care ethics. About 69% of the respondents had good practice of health-care ethics. Age group, sex, specialty, and duration of work experience had no significant association with attitude toward health-care ethics. Age group had significant correlation with practice while sex, specialty, and duration of work experience did not. Conclusion: Nine-tenth of respondents were aware of the definition of health-care ethics. Three-fourth was aware of duties of ethical committee. Nearly two-third of the respondents had positive attitude toward health-care ethics. More than two-third of the respondents had good practice of health-care ethics.","PeriodicalId":14153,"journal":{"name":"International Journal of Medical Science and Public Health","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77608197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study of risk factors and epidemiologic profile of posterior polar cataract/posterior subcapsular cataract in Northwest Rajasthan 拉贾斯坦邦西北部后极性白内障/后囊下白内障危险因素及流行病学分析
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.034324052020
Poonam Bhargava, K. Jain, Lakshita Maherda
Background: In India, cataract is the foremost cause of blindness, leading to the mild-to-severe morbidity. Objective: The objective of the study was to find out the epidemiologic profile and risk factors of posterior polar cataract/posterior subcapsular cataract. Materials and Methods: A prospective non-comparative observational study involving 50 patients having posterior polar cataracts attending our outpatient department was selected and was questioned about their locality, systemic diseases, ocular disease, and use of steroid in any form which were included in the study. Results: Of the 50 patients, 30 were male and 20 females, most patients were in the age group of 61–70 years. About 66% of the patient belongs to the rural locality. Most of the females were homemaker, 24% were farmer, 8% were shopkeeper, and 6% retired persons while 2% each of electrician, computer programmer, and bus driver. About 48% had bilateral cataracts, 42% (21) were pseudophakic in one eye, and 1% (5) unilateral cataract. About 24% of patients had hypertension, 18% of patients had of asthma/chronic obstructive pulmonary disease, 16% of patients had diabetes mellitus, 2% of patients had h/o arthritis, 8% had skin disease, 6% had h/o injudicious use of over-the-counter topical drops while 4% of patients of thyroid disease were noted and 34% of patients had h/o steroid use. The most common type of cataract seen Grade I (52%, 26 patients), followed by Grade II (36%, 18 patients), Grade III (8%, 4 patients), and Grade IV (4%, 2 patients). Conclusion: With increasing injudicious use of steroid can result in formation of posterior polar/posterior subcapsular cataract in young age and professional office class workers who are seeking medical help at early stage. An ultrasound should be done to rule out posterior capsular defect if suspected and the patient should be counseled well about the complication prior taking into surgery.
背景:在印度,白内障是致盲的首要原因,发病率从轻到重度不等。目的:了解后极性白内障/后囊下白内障的流行病学特点及危险因素。材料和方法:选择一项前瞻性非比较观察性研究,涉及50例在我们门诊就诊的后极性白内障患者,并询问他们的部位、全身性疾病、眼部疾病以及研究中任何形式的类固醇使用情况。结果:50例患者中,男性30例,女性20例,年龄以61 ~ 70岁为主。约66%的患者来自农村地区。女性以家庭主妇居多,农民占24%,店主占8%,退休人员占6%,电工、计算机程序员和公共汽车司机各占2%。约48%为双侧白内障,42%(21)为单眼假性晶状体,1%(5)为单侧白内障。约24%的患者患有高血压,18%的患者患有哮喘/慢性阻塞性肺病,16%的患者患有糖尿病,2%的患者患有关节炎,8%的患者患有皮肤病,6%的患者不明智地使用非处方局部滴剂,4%的患者患有甲状腺疾病,34%的患者使用类固醇。最常见的白内障类型是一级(52%,26例),其次是二级(36%,18例),三级(8%,4例)和四级(4%,2例)。结论:类固醇的不明智使用可导致年轻和早期寻求医疗帮助的专业办公室工作人员后极/后囊下白内障的形成。如果怀疑有后囊膜缺损,应进行超声检查以排除后囊膜缺损,并在手术前告知患者有关并发症。
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引用次数: 1
A prospective study on treatment of recurrent epithelial ovarian cancer with gemcitabine and pegylated liposomal doxorubicin 吉西他滨和聚乙二醇化脂质体阿霉素治疗复发性上皮性卵巢癌的前瞻性研究
Pub Date : 2020-01-01 DOI: 10.5455/ijmsph.2020.12348201930012020
T. Das, K. Chatterjee
Background: Rechallenge of a platinum-based chemotherapy is the most common approach for a recurrent platinumsensitive epithelial carcinoma ovary. However, this carries a substantial risk of cumulative neurotoxicity. Objectives: In the present study, we tried to compare the efficacy and toxicities of gemcitabine pegylated liposomal doxorubicin combination regimen to rechallenge of paclitaxel-carboplatin in this setting. Materials and Methods: A total of 30 patients were included in the study. The patients were randomized into two groups each containing 15 patients. The study group received injection gemcitabine at the dose of 1 g/m2 injection intravenously on day 1 and day 8 and liposomal doxorubicin 30 mg/m2 on day 1 in a 3 weekly cycle up to a total of six cycles in absence of disease progression or unacceptable toxicities. The control group patients were treated with injection paclitaxel at a dose of 175 mg/m2 I/V infusion and injection carboplatin at a dose considering area under the curve 6 in a 3 weekly for six cycles. Results: In the study arm, out of 14 patients, 4 (28.57%) patients had complete response, 6 (42.85%) had partial response, 3 (21.42%) had stable disease, and 1 (7.14%) showed disease progression. In the control arm, 6 (40%) patients out of 15 showed complete response, and 4 (26.66%) partial response. Disease progression was noted in 1 (6.66%) patient. There was less incidence of neurotoxicity compared to the control arm. Conclusion: Chemotherapy with a combination of gemcitabine and pegylated liposomal doxorubicin shows equivalent efficacy in platinum-sensitive recurrent ovarian cancer when compared to rechallenge of platinum-based chemotherapy. The regimen has an acceptable toxicity profile with lesser incidence of neuropathy than rechallenge of paclitaxel-carboplatin combination.
背景:铂基化疗是复发性卵巢铂敏感上皮癌最常见的治疗方法。然而,这带来了累积神经毒性的巨大风险。目的:在本研究中,我们试图比较吉西他滨聚乙二醇脂质体阿霉素联合方案在这种情况下对紫杉醇-卡铂的再挑战的疗效和毒性。材料与方法:共纳入30例患者。患者随机分为两组,每组15例。研究组在没有疾病进展或不可接受的毒性的情况下,在第1天和第8天静脉注射剂量为1 g/m2的吉西他滨,在第1天注射剂量为30 mg/m2的脂质体阿霉素,以3周为一个周期,总共6个周期。对照组患者注射紫杉醇,剂量为175 mg/m2 I/V输注,卡铂注射剂量考虑曲线下面积6,每3周治疗6个周期。结果:研究组14例患者中,完全缓解4例(28.57%),部分缓解6例(42.85%),病情稳定3例(21.42%),疾病进展1例(7.14%)。在对照组中,15例患者中有6例(40%)完全缓解,4例(26.66%)部分缓解。1例(6.66%)患者出现疾病进展。与对照组相比,神经毒性发生率较低。结论:吉西他滨联合聚乙二醇化脂质体多柔比星联合化疗与铂基化疗相比,对铂敏感的复发性卵巢癌疗效相当。该方案具有可接受的毒性,与紫杉醇-卡铂联合治疗相比,其神经病变发生率较低。
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引用次数: 0
期刊
International Journal of Medical Science and Public Health
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