B. P. Pakhira, Abhinandan Ghosh, Adrija Tripathy, D. Ghosh
Currently available contraceptives are associated with adverse effects. So, search on safer agents in this purpose is one of the priority areas of WHO. Our previous study showed a significant antifertility effect of hydro-methanol extract of Cuminum cyminum Linn (Umbelliferae) in male albino rat. The main objective of this work isto search outthe potentfraction of hydro-methanol extract of seed of Cuminum cyminum in adult male albino rat for the development of herbal male contraceptive to reduce the bio-burden of phytomolecules. The n-hexane, chloroform, ethyl acetate, and n-butanol fractions of the hydro-methanol (2:3) extract of seed of Cuminum cyminum were administrated orally to male rat. Results showed the maximum antitesticular activity of chloroform fraction (CH-Fr) than other fractions included here. Treatment with CH-Fr fraction resulted a significant inhibition in spermiological parameters, activities of testicular androgenic key enzymes and antioxidative enzymes, levels of serum testosterone and seminal vesicular fructose, number of different generations of germ cells at stage VII of spermatogenic cell cycle and seminiferous tubular diameter (STD) along with significant increase in the level of testicular cholesterol in respect to the control. Significant upward and downward expression in Bax and Bcl-2 gene of male germ cells were indicated which focussed the sperm apoptotic enhancer activities of the fraction. The findings indicated that among the said four different fractions, the chloroform fraction of the hydro-methanol extract of the seed of Cuminum cyminum had most effective antitesticular activity.
{"title":"Antitesticular activities of different solvent fractions from hydro-methanol (2:3) extract of Cuminum cyminum in albino rat: A Comparative analysis","authors":"B. P. Pakhira, Abhinandan Ghosh, Adrija Tripathy, D. Ghosh","doi":"10.5138/09750185.2131","DOIUrl":"https://doi.org/10.5138/09750185.2131","url":null,"abstract":"Currently available contraceptives are associated with adverse effects. So, search on safer agents in this purpose is one of the priority areas of WHO. Our previous study showed a significant antifertility effect of hydro-methanol extract of Cuminum cyminum Linn (Umbelliferae) in male albino rat. The main objective of this work isto search outthe potentfraction of hydro-methanol extract of seed of Cuminum cyminum in adult male albino rat for the development of herbal male contraceptive to reduce the bio-burden of phytomolecules. The n-hexane, chloroform, ethyl acetate, and n-butanol fractions of the hydro-methanol (2:3) extract of seed of Cuminum cyminum were administrated orally to male rat. Results showed the maximum antitesticular activity of chloroform fraction (CH-Fr) than other fractions included here. Treatment with CH-Fr fraction resulted a significant inhibition in spermiological parameters, activities of testicular androgenic key enzymes and antioxidative enzymes, levels of serum testosterone and seminal vesicular fructose, number of different generations of germ cells at stage VII of spermatogenic cell cycle and seminiferous tubular diameter (STD) along with significant increase in the level of testicular cholesterol in respect to the control. Significant upward and downward expression in Bax and Bcl-2 gene of male germ cells were indicated which focussed the sperm apoptotic enhancer activities of the fraction. The findings indicated that among the said four different fractions, the chloroform fraction of the hydro-methanol extract of the seed of Cuminum cyminum had most effective antitesticular activity.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"27 1","pages":"605-614"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77225875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sornalakshmi, P. S. Tresina, K. Paulpriya, V. Mohan
Hypericum is a well-known plant genus in herbal medicine. Hypericum mysorense is well known in folklore medicine for its varied therapeutic potential. The in vitro antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extract of leaf of Hypericum mysorense have been tested using various antioxidant model systems viz; DPPH, hydroxyl, superoxide, ABTS and reducing power. The scavenging effect increases with the concentration of standard and samples. Among the solvent tested, ethanol extract exhibited highest DPPH (116.33% inhibition), hydroxyl (101.84%), superoxide (116.09%) and ABTS (119.22%) radical scavenger activity. Methanol extract of H.mysorense shows the highest reducing ability. The aim and purpose of this study is to show the significant free radical scavenging potential of H.mysorense leaf which can be experimented for the treatment of various free radical mediated ailments
{"title":"Evaluation of free radical scavenging activity of leaf of Hypericum mysorense Heyne","authors":"Sornalakshmi, P. S. Tresina, K. Paulpriya, V. Mohan","doi":"10.5138/09750185.2137","DOIUrl":"https://doi.org/10.5138/09750185.2137","url":null,"abstract":"Hypericum is a well-known plant genus in herbal medicine. Hypericum mysorense is well known in folklore medicine for its varied therapeutic potential. The in vitro antioxidant activity of petroleum ether, benzene, ethyl acetate, methanol and ethanol extract of leaf of Hypericum mysorense have been tested using various antioxidant model systems viz; DPPH, hydroxyl, superoxide, ABTS and reducing power. The scavenging effect increases with the concentration of standard and samples. Among the solvent tested, ethanol extract exhibited highest DPPH (116.33% inhibition), hydroxyl (101.84%), superoxide (116.09%) and ABTS (119.22%) radical scavenger activity. Methanol extract of H.mysorense shows the highest reducing ability. The aim and purpose of this study is to show the significant free radical scavenging potential of H.mysorense leaf which can be experimented for the treatment of various free radical mediated ailments","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"12 1","pages":"589-596"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89369759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Ugwu, Joseph Effiong Eyo, Jude Ifeanyi Egbuji, C. S. Ezechukwu, K. N. Ibemenuga
The increasing discovery of more medicinal plants have triggered increased scientific screening of their bioactivity in order to provide data that will help physicians and patients make wise decision before using them. This study was designed to elucidate comparative phytochemical and antioxidant properties of crude seed powder, aqueous and methanolic seed extracts of Buchholzia coriacea. The results showed that crude seed powder had the highest alkaloid and phenol content of 3.98 ± 0.00% and 0.92 ± 0.00%, while aqueous extract had the least alkaloid and phenol content of 1.00 ± 0.00% and 0.12 ± 0.00% respectively. Methanolic extracts had the highest phytochemical components among the three extracts with flavonoids (12.03 ± 0.0), saponins (1.99 ± 0.01), terpenoids (2.00 ± 0.00), tannin (0.10 ± 0.00) and phytate (2.02 ± 0.01) compositions, while aqueous extracts had the highest hydrogen cyanide (0.30 ± 0.00) and glycoside (0.35 ± 0.00). Antioxidant (DPPH) activities of B. coriacea showed that aqueous extract and crude seed powder had inhibition concentration (IC 50 ) of 4.65 mg/ml while methanolic extract had IC 50 of 5.85 mg/ml. The result of the LD 50 of the extracts showed the each extracts was well tolerated at a dose of 5000 mg/kg, an indication of high safety profile. The study therefore clearly demonstrated that methanolic extracts of B. coriacea have antioxidant, antihypertensive, hypocholesterolmic and anticarcinogenic properties owing to the presence of high levels of phytochemical components than the aqueous and crude seed powder.
{"title":"Comparative phytochemical and antioxidant profile of crude seed powder, aqueous and methanolic seed extracts of Buchholzia coriacea","authors":"G. Ugwu, Joseph Effiong Eyo, Jude Ifeanyi Egbuji, C. S. Ezechukwu, K. N. Ibemenuga","doi":"10.5138/09750185.2117","DOIUrl":"https://doi.org/10.5138/09750185.2117","url":null,"abstract":"The increasing discovery of more medicinal plants have triggered increased scientific screening of their bioactivity in order to provide data that will help physicians and patients make wise decision before using them. This study was designed to elucidate comparative phytochemical and antioxidant properties of crude seed powder, aqueous and methanolic seed extracts of Buchholzia coriacea. The results showed that crude seed powder had the highest alkaloid and phenol content of 3.98 ± 0.00% and 0.92 ± 0.00%, while aqueous extract had the least alkaloid and phenol content of 1.00 ± 0.00% and 0.12 ± 0.00% respectively. Methanolic extracts had the highest phytochemical components among the three extracts with flavonoids (12.03 ± 0.0), saponins (1.99 ± 0.01), terpenoids (2.00 ± 0.00), tannin (0.10 ± 0.00) and phytate (2.02 ± 0.01) compositions, while aqueous extracts had the highest hydrogen cyanide (0.30 ± 0.00) and glycoside (0.35 ± 0.00). Antioxidant (DPPH) activities of B. coriacea showed that aqueous extract and crude seed powder had inhibition concentration (IC 50 ) of 4.65 mg/ml while methanolic extract had IC 50 of 5.85 mg/ml. The result of the LD 50 of the extracts showed the each extracts was well tolerated at a dose of 5000 mg/kg, an indication of high safety profile. The study therefore clearly demonstrated that methanolic extracts of B. coriacea have antioxidant, antihypertensive, hypocholesterolmic and anticarcinogenic properties owing to the presence of high levels of phytochemical components than the aqueous and crude seed powder.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"16 1","pages":"558-565"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75181393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The anticancer activity of crude extracts of the leaves of Tridax procumbens, against two breast cancer cell lines-MCF-7 (benign) and MDA-MB-231 (metastatic) were investigated and an attempt was made to identify the anticancer principle. The extracts with methanol (TPM), ethanol (TPE) and chloroform (TPC) as solvents were screened for cytotoxicity by MTT assay against MCF-7 cells. The effective extract was further evaluated on MDA-MB-231 cells. Among the three extracts, TPC was effective at an IC 50 value of 136 µg/ml and 129 µg/ml on MCF-7 and MDA-MB-231 cells respectively. Phytochemical analysis of the extract showed the presence of only steroids and terpenoids and their concentration was high (77.4% w/w). HPLC-MS of the chloroform soluble crude extract revealed a major peak (57.59% concentration) at a retention time of 4.78 min and MS data of this peak revealed presence of two fragments of molecular weight 475.80 and 701.80. The compounds were identified to be 3β, 9β-Dihydroxy-18α-oleanan-28-oic acid, a derivative of oleanolic acid and 3β, 28-Bis (cinnamoyl) betulin respectively, both from the triterpenoid family.
{"title":"Triterpenoids with Cytotoxic Potential from the Leaves of Tridax procumbens L.","authors":"Vaishali M. Rai, V. Pai, S. R. Duwal","doi":"10.5138/09750185.2109","DOIUrl":"https://doi.org/10.5138/09750185.2109","url":null,"abstract":"The anticancer activity of crude extracts of the leaves of Tridax procumbens, against two breast cancer cell lines-MCF-7 (benign) and MDA-MB-231 (metastatic) were investigated and an attempt was made to identify the anticancer principle. The extracts with methanol (TPM), ethanol (TPE) and chloroform (TPC) as solvents were screened for cytotoxicity by MTT assay against MCF-7 cells. The effective extract was further evaluated on MDA-MB-231 cells. Among the three extracts, TPC was effective at an IC 50 value of 136 µg/ml and 129 µg/ml on MCF-7 and MDA-MB-231 cells respectively. Phytochemical analysis of the extract showed the presence of only steroids and terpenoids and their concentration was high (77.4% w/w). HPLC-MS of the chloroform soluble crude extract revealed a major peak (57.59% concentration) at a retention time of 4.78 min and MS data of this peak revealed presence of two fragments of molecular weight 475.80 and 701.80. The compounds were identified to be 3β, 9β-Dihydroxy-18α-oleanan-28-oic acid, a derivative of oleanolic acid and 3β, 28-Bis (cinnamoyl) betulin respectively, both from the triterpenoid family.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"4 1","pages":"597-604"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87088259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The initial introduction of new medicinal agents into the health care system sometimes, requires information beyond that is recorded in libraries relying instead, on reports available through traditions and healers within a society. This paper explored the antibacterial activity of aqueous and hydromethanolic extracts of nine folkloric medicinal plant from Bechar region (southwest Algeria) namely: A. nardus, A. schoenanthus, G. vulgaris, two species of H. scoparia green & red, P. laevigata, R. tripartita, T. gallica and T. nudatum , frequently used in the local traditional medicine. The antibacterial activity of different extracts were evaluated by using disc diffusion method agar and antibiotics susceptibility of ten selected microorganisms: seven reference strains, Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae, Pseudomonas aeruginosa , Salmonella typhi , and three clinically isolated strains, Escherichia coli (Urinary Tract Infection), Escherichia coli (Vaginal Infection) and Staphylococcus aureus (Skin Infection). The maximum antibacterial activity was recorded against the gram negative reference strains Pseudomonas aeruginosa and Escherichia coli with a maximum inhibition diameter of 15.6 ± 0.5 and 15.0 ± 1.4 mm respectively displayed by the aqueous extract of T. gallica, followed by the activity detected by the hydromethanolic extract of R. tripartita against the gram negative reference strain Pseudomonas aeruginosa (14.6±1.2 mm) and the aqueous and hydromethanolic extracts of R. tripartita against the gram negative reference strains Pseudomonas aeruginosa and Escherichia coli with a maximum inhibition diameter of 14.3 ± 2.0 and 14.3±0.5 mm, respectively. According to the present study, H. scoparia red, P. laevigata, R. tripartita, and T. gallica can be served as broad spectrum antibiotic and used as a potent source of natural antibacterial agents by replacing commercially available synthetic drug that may have a large number of side effects.
{"title":"Screening of some plant materials used in South-West Algerian traditional medicine for their antibacterial activity","authors":"Fatehi Naima, H. Benmehdi, A. Hocine, O. Nawal","doi":"10.5138/09750185.2161","DOIUrl":"https://doi.org/10.5138/09750185.2161","url":null,"abstract":"The initial introduction of new medicinal agents into the health care system sometimes, requires information beyond that is recorded in libraries relying instead, on reports available through traditions and healers within a society. This paper explored the antibacterial activity of aqueous and hydromethanolic extracts of nine folkloric medicinal plant from Bechar region (southwest Algeria) namely: A. nardus, A. schoenanthus, G. vulgaris, two species of H. scoparia green & red, P. laevigata, R. tripartita, T. gallica and T. nudatum , frequently used in the local traditional medicine. The antibacterial activity of different extracts were evaluated by using disc diffusion method agar and antibiotics susceptibility of ten selected microorganisms: seven reference strains, Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus , Escherichia coli , Klebsiella pneumoniae, Pseudomonas aeruginosa , Salmonella typhi , and three clinically isolated strains, Escherichia coli (Urinary Tract Infection), Escherichia coli (Vaginal Infection) and Staphylococcus aureus (Skin Infection). The maximum antibacterial activity was recorded against the gram negative reference strains Pseudomonas aeruginosa and Escherichia coli with a maximum inhibition diameter of 15.6 ± 0.5 and 15.0 ± 1.4 mm respectively displayed by the aqueous extract of T. gallica, followed by the activity detected by the hydromethanolic extract of R. tripartita against the gram negative reference strain Pseudomonas aeruginosa (14.6±1.2 mm) and the aqueous and hydromethanolic extracts of R. tripartita against the gram negative reference strains Pseudomonas aeruginosa and Escherichia coli with a maximum inhibition diameter of 14.3 ± 2.0 and 14.3±0.5 mm, respectively. According to the present study, H. scoparia red, P. laevigata, R. tripartita, and T. gallica can be served as broad spectrum antibiotic and used as a potent source of natural antibacterial agents by replacing commercially available synthetic drug that may have a large number of side effects.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"9 1","pages":"619-627"},"PeriodicalIF":0.0,"publicationDate":"2017-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82164328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cordia macleodii Hook. f. & Thoms. belongs to family Boraginaceae, is an endangered medicinal plant, commonly known as “Dahiman” or “Dahipalas”. It is distributed in moist and dry deciduous forests of India such as Chhattisgarh, Madhya Pradesh, Odisha, Chotanagpur and is widely used to cure various diseases. These bioactive compounds made this plant as a valuable potent herbal drug. It contains various bioactive compounds including Phenols, Terpenoids, Saponins, Volatile oils, Flavonoids, Glycosides etc. This review presents the pharmacological property, phytochemical constituents, traditional uses and biological activities of the plant and it will be helpful to explore the knowledge about Cordia macleodii .
{"title":"Cordia macleodii Hook f. Thomson-A potential Medicinal Plant","authors":"Jagriti Chandrakar, A. Dixit","doi":"10.5138/09750185.2105","DOIUrl":"https://doi.org/10.5138/09750185.2105","url":null,"abstract":"Cordia macleodii Hook. f. & Thoms. belongs to family Boraginaceae, is an endangered medicinal plant, commonly known as “Dahiman” or “Dahipalas”. It is distributed in moist and dry deciduous forests of India such as Chhattisgarh, Madhya Pradesh, Odisha, Chotanagpur and is widely used to cure various diseases. These bioactive compounds made this plant as a valuable potent herbal drug. It contains various bioactive compounds including Phenols, Terpenoids, Saponins, Volatile oils, Flavonoids, Glycosides etc. This review presents the pharmacological property, phytochemical constituents, traditional uses and biological activities of the plant and it will be helpful to explore the knowledge about Cordia macleodii .","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"24 1","pages":"394-398"},"PeriodicalIF":0.0,"publicationDate":"2017-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84970488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Obiang, R. Ngoua-Meye-Misso, Guy-Roger Ndong-Atome, J. Ondo, L. Obame-Engonga, E. Nsi-Emvo
Aim of this work was to evaluate the phytochemical constituents, antioxidant and antimicrobial potential of water-acetone, water-ethanol and water extracts of Englerina gabonensis and Sterculia tragacantha .Presence of phenols was evaluated to estimate the effects of plants on microbial diseases. Water-acetone, water-ethanol and water extracts were examined for antioxidant activities. All plant extracts were tested against six reference strains, eleven clinical isolates and two fungal strains. Phenolic content were highest in the water-acetone and water-ethanol extracts from Englerinagabonensis in comparison with Sterculia tragacantha .The AAI (Antioxidant Activity Index)of water-acetone and water-ethanol extracts of Englerina gabunensis are superiors with 2. Plant extracts of Sterculia tragacantha show weak antioxidant activity (AAI < 0.5).The aqueous extract of Englerina gabonensis has a bactericidal effect on Salmonella Spp . Water-ethanol extract is bactericidal on Bacillus cereus LMG 13569 BHI, Salmonella Spp and Neisseria meningitides. Water-acetone extract presents a bactericidal activity on Enterococcus faecalis 103907 CIP, Escherichi coli , Staphylococcus aureus , Acinetobacter baumannii and Neisseria meningitides. Our results suggest that Englerina gabonensis extracts contain greater antioxidant and antimicrobial properties than Sterculia tragacantha extracts.
{"title":"Chemical composition, antioxidant and antimicrobial activities of stem barks of Englerina gabonensis Engler and Sterculia tragacantha Lindl from Gabon","authors":"C. Obiang, R. Ngoua-Meye-Misso, Guy-Roger Ndong-Atome, J. Ondo, L. Obame-Engonga, E. Nsi-Emvo","doi":"10.5138/09750185.2124","DOIUrl":"https://doi.org/10.5138/09750185.2124","url":null,"abstract":"Aim of this work was to evaluate the phytochemical constituents, antioxidant and antimicrobial potential of water-acetone, water-ethanol and water extracts of Englerina gabonensis and Sterculia tragacantha .Presence of phenols was evaluated to estimate the effects of plants on microbial diseases. Water-acetone, water-ethanol and water extracts were examined for antioxidant activities. All plant extracts were tested against six reference strains, eleven clinical isolates and two fungal strains. Phenolic content were highest in the water-acetone and water-ethanol extracts from Englerinagabonensis in comparison with Sterculia tragacantha .The AAI (Antioxidant Activity Index)of water-acetone and water-ethanol extracts of Englerina gabunensis are superiors with 2. Plant extracts of Sterculia tragacantha show weak antioxidant activity (AAI < 0.5).The aqueous extract of Englerina gabonensis has a bactericidal effect on Salmonella Spp . Water-ethanol extract is bactericidal on Bacillus cereus LMG 13569 BHI, Salmonella Spp and Neisseria meningitides. Water-acetone extract presents a bactericidal activity on Enterococcus faecalis 103907 CIP, Escherichi coli , Staphylococcus aureus , Acinetobacter baumannii and Neisseria meningitides. Our results suggest that Englerina gabonensis extracts contain greater antioxidant and antimicrobial properties than Sterculia tragacantha extracts.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"30 1","pages":"501-510"},"PeriodicalIF":0.0,"publicationDate":"2017-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76560772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dingom Aurelie Taylor Patience, Keugni Armand Brice, Bendegue Emebe Alexandrie Julia, D. Désiré, Kamtchouing Pierre, T. Dimo
Inflammation is frequently associated with pain. Plants continue to be major resources for therapeutic compounds against various diseases including inflammation and pain. P aullinia Pinnata is used to treat several diseases, including rheumatism and abdominal pain. This study was undertaken to assess the analgesic and anti-inflammatory effects of P aullinia Pinnata. The analgesic activity was evaluated by using behaviour pain model in mice. The anti-inflammatory activity was carried out by using carrageenan, dextran, histamine and serotonin induced inflammation in rat. The extract was administered orally at a dose of 200 and 400 mg/kg. The results showed that the extract significantly (P< 0.001) reduced the number of writhing induced by the acid acetic. The aqueous extract reduced significantly (P< 0.001) the paw licking time in formalin model. The effect of the extract (200mg/kg) was significantly (P< 0.001) reduced in the presence of naloxone, during the inflammatory phase. In addition, the extract significantly (P< 0.05) increase latency time at all point time and all doses on nociception induced by hot plate. Concerning inflammation induced by carrageenan and dextran, the extract significantly (P< 0.001) inhibited oedema during the experimental time at the dose of 200 mg/kg. The results suggested that Paullinia pinnata aqueous extract possess analgesic activities which may interfere in both peripheral and central pathway. The anti-inflammatory activities may be mediated by either inhibiting or by blocking the release of vasoactive substances like histamine, serotonin, kinins and prostaglandins. These results justify the traditional use of the plant in the treatment of pain and inflammation.
{"title":"Analgesic and acute inflammation properties of the aqueous extract of dried leaves of Paullinia Pinnata (Sapindaceae) Linn","authors":"Dingom Aurelie Taylor Patience, Keugni Armand Brice, Bendegue Emebe Alexandrie Julia, D. Désiré, Kamtchouing Pierre, T. Dimo","doi":"10.5138/09750185.2115","DOIUrl":"https://doi.org/10.5138/09750185.2115","url":null,"abstract":"Inflammation is frequently associated with pain. Plants continue to be major resources for therapeutic compounds against various diseases including inflammation and pain. P aullinia Pinnata is used to treat several diseases, including rheumatism and abdominal pain. This study was undertaken to assess the analgesic and anti-inflammatory effects of P aullinia Pinnata. The analgesic activity was evaluated by using behaviour pain model in mice. The anti-inflammatory activity was carried out by using carrageenan, dextran, histamine and serotonin induced inflammation in rat. The extract was administered orally at a dose of 200 and 400 mg/kg. The results showed that the extract significantly (P< 0.001) reduced the number of writhing induced by the acid acetic. The aqueous extract reduced significantly (P< 0.001) the paw licking time in formalin model. The effect of the extract (200mg/kg) was significantly (P< 0.001) reduced in the presence of naloxone, during the inflammatory phase. In addition, the extract significantly (P< 0.05) increase latency time at all point time and all doses on nociception induced by hot plate. Concerning inflammation induced by carrageenan and dextran, the extract significantly (P< 0.001) inhibited oedema during the experimental time at the dose of 200 mg/kg. The results suggested that Paullinia pinnata aqueous extract possess analgesic activities which may interfere in both peripheral and central pathway. The anti-inflammatory activities may be mediated by either inhibiting or by blocking the release of vasoactive substances like histamine, serotonin, kinins and prostaglandins. These results justify the traditional use of the plant in the treatment of pain and inflammation.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"76 1","pages":"490-497"},"PeriodicalIF":0.0,"publicationDate":"2017-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86182097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The family Anacardiacea, best represented by the species Pistacia integrrima Stewart ex Brandis, is known worldwide for its manifold uses. It is widely used to cure various diseases like cold, cough, asthma, fever, vomiting and diarrhea, etc., and widely used in modern medicine. Therefore, an attempt has been made to assess the medicinal potential of the species both in traditional as well as in modern medicine system. These properties are supposed to be cured by different active compounds present in the plant. This paper provides the relevant information about medicinal properties of this high value medicinal plant .
阿纳卡迪亚科，最具代表性的物种是阿纳卡迪亚(Pistacia integrrima Stewart ex Brandis)，以其多种用途而闻名世界。它被广泛用于治疗感冒、咳嗽、哮喘、发烧、呕吐、腹泻等各种疾病，在现代医学中应用广泛。因此，试图评估该物种在传统和现代医学系统中的药用潜力。这些特性被认为是由植物中存在的不同活性化合物固化的。本文介绍了这种高价值药用植物的药用特性。
{"title":"Pistacia integrrima Stewart ex Brandis: a less known high value medicinal plant","authors":"B. Sharma, Sheezan Rasool, S. Pant","doi":"10.5138/09750185.2037","DOIUrl":"https://doi.org/10.5138/09750185.2037","url":null,"abstract":"The family Anacardiacea, best represented by the species Pistacia integrrima Stewart ex Brandis, is known worldwide for its manifold uses. It is widely used to cure various diseases like cold, cough, asthma, fever, vomiting and diarrhea, etc., and widely used in modern medicine. Therefore, an attempt has been made to assess the medicinal potential of the species both in traditional as well as in modern medicine system. These properties are supposed to be cured by different active compounds present in the plant. This paper provides the relevant information about medicinal properties of this high value medicinal plant .","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"77 1","pages":"390-393"},"PeriodicalIF":0.0,"publicationDate":"2017-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79653771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahendra S. Khyade, Subhash N Varpe, Anup D. Padwal
The present study was conducted to evaluate the antioxidant activity and chemical composition of aqueous methanolic extract of Trichodesma indicum (L.) R.Br. The extract was tested for antioxidant activity using various in vitro models viz., DPPH, ABTS, NO, FRAP, total antioxidant activity and reducing power. The total phenolic and flavonoid contents were found to be equivalents to 97.83 ± 0.08 µg of gallic acid and 45.45 ± 0.19 µg of rutin /mg of dried aqueous methanolic extract, respectively. Among various antioxidant assays performed, maximum inhibition was observed in the ABTS (IC 50 17.13 ± 0.23 μg) followed by DPPH (IC 50 80.64 ± 0.29 μg) and NO (IC 50 4.12 ± 0.02 μg) assay. GC-MS analysis revealed the presence of over 38 compounds, the prevailing compounds were hexadecanoic acid, β-sitosterol, ethyl iso-allocholate and 9,12,15,-Octadecatrienoicacid. The HPLC analysis further confirmed the presence of rutin, salicylic acid and benzoic acid. This confirms that T. indicum could be the good source of natural antioxidant for industrial and pharmaceutical preparations.
{"title":"Evaluation of chemical profile and antioxidant potential of Trichodesma indicum (L.) R.Br.","authors":"Mahendra S. Khyade, Subhash N Varpe, Anup D. Padwal","doi":"10.5138/09750185.2012","DOIUrl":"https://doi.org/10.5138/09750185.2012","url":null,"abstract":"The present study was conducted to evaluate the antioxidant activity and chemical composition of aqueous methanolic extract of Trichodesma indicum (L.) R.Br. The extract was tested for antioxidant activity using various in vitro models viz., DPPH, ABTS, NO, FRAP, total antioxidant activity and reducing power. The total phenolic and flavonoid contents were found to be equivalents to 97.83 ± 0.08 µg of gallic acid and 45.45 ± 0.19 µg of rutin /mg of dried aqueous methanolic extract, respectively. Among various antioxidant assays performed, maximum inhibition was observed in the ABTS (IC 50 17.13 ± 0.23 μg) followed by DPPH (IC 50 80.64 ± 0.29 μg) and NO (IC 50 4.12 ± 0.02 μg) assay. GC-MS analysis revealed the presence of over 38 compounds, the prevailing compounds were hexadecanoic acid, β-sitosterol, ethyl iso-allocholate and 9,12,15,-Octadecatrienoicacid. The HPLC analysis further confirmed the presence of rutin, salicylic acid and benzoic acid. This confirms that T. indicum could be the good source of natural antioxidant for industrial and pharmaceutical preparations.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"113 1","pages":"416-425"},"PeriodicalIF":0.0,"publicationDate":"2017-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80199268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：