To investigate the protective role of broccoli powder “ Brassica Oleracea Italica ” against continuous ingestion of escitalopram antidepressant drug induced hepatotoxicity in Swiss albino male mice. Mice were divided into different groups. Group1: Normal control (0.9% NaCl), Group 2: Escitalopram drug treated only (20 mg/kg), Group 3: Broccoli powder with Escitalopram drug treated (200 mg/kg + 20 mg/kg), Group 4: Olive oil vehicle control, Group 5: Carbon tetrachloride (CCl 4 ) referenced as positive control (33 mg/kg), Group 6: Broccoli powder with CCl 4 treated (200 mg/kg + 33 mg/kg). The effect of these groups on liver tissue was studied after three different time periods for 4, 8 and 12 weeks. The results showed that the treatment with escitalopram drug displayed significantly increased serum SGOT, SGPT, ALP level and alter liver antioxidant enzymes level (LPO, SOD and GSH) that are comparable with CCl 4 intoxicated group considered as positive control. Comparing escitalopram drug treated group with group that received both broccoli powder and escitalopram drug displayed a significant decrease in serum SGOT, SGPT, ALP levels and restored the level of antioxidant enzymes. The protective effect of broccoli powder on escitalopram drug induced hepatotoxicity was also supported by histopathological studies.
{"title":"Protective role of Broccoli powder against continuous ingestion of Escitalopram antidepressant drug induced hepatotoxicity in Swiss albino male mice","authors":"S. Saxena, L. Shahani, P. Bhatnagar","doi":"10.5138/09750185.2104","DOIUrl":"https://doi.org/10.5138/09750185.2104","url":null,"abstract":"To investigate the protective role of broccoli powder “ Brassica Oleracea Italica ” against continuous ingestion of escitalopram antidepressant drug induced hepatotoxicity in Swiss albino male mice. Mice were divided into different groups. Group1: Normal control (0.9% NaCl), Group 2: Escitalopram drug treated only (20 mg/kg), Group 3: Broccoli powder with Escitalopram drug treated (200 mg/kg + 20 mg/kg), Group 4: Olive oil vehicle control, Group 5: Carbon tetrachloride (CCl 4 ) referenced as positive control (33 mg/kg), Group 6: Broccoli powder with CCl 4 treated (200 mg/kg + 33 mg/kg). The effect of these groups on liver tissue was studied after three different time periods for 4, 8 and 12 weeks. The results showed that the treatment with escitalopram drug displayed significantly increased serum SGOT, SGPT, ALP level and alter liver antioxidant enzymes level (LPO, SOD and GSH) that are comparable with CCl 4 intoxicated group considered as positive control. Comparing escitalopram drug treated group with group that received both broccoli powder and escitalopram drug displayed a significant decrease in serum SGOT, SGPT, ALP levels and restored the level of antioxidant enzymes. The protective effect of broccoli powder on escitalopram drug induced hepatotoxicity was also supported by histopathological studies.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"62 1","pages":"296-304"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90335439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amol Chandekar, A. Vyas, Neeraj Upamanyu, Atul Tripathi, S. Agrawal
The investigation on anti-inflammatory activity of the various extract of Waltheria indica L. was reported to find out the pharmacological basis for its ethnomedical use. The anti-inflammatory activity of the pet ether (PEW) and methanol (MEW) extracts of the leaves of Waltheria indica L. ( Malvaceae ) were evaluated by using in vivo (Carrageenan & histamine induced rat paw edema, cotton pellet granuloma test) models. It was observed that, all the extracts showed significant activity in the in-vivo model at the dose of 500 mg/kg b.w. orally, when compared with control and standard drugs. Of the two extracts tested, methanol extract MEW showed most significant activity well in comparison to the standard drug. Therefore, present study suggests, potential of leaves of Waltheria indica L. in both models of acute and chronic inflammation.
{"title":"Preliminary screening of Waltheria indica (L.) plant for its anti-inflammatory activity","authors":"Amol Chandekar, A. Vyas, Neeraj Upamanyu, Atul Tripathi, S. Agrawal","doi":"10.5138/09750185.2079","DOIUrl":"https://doi.org/10.5138/09750185.2079","url":null,"abstract":"The investigation on anti-inflammatory activity of the various extract of Waltheria indica L. was reported to find out the pharmacological basis for its ethnomedical use. The anti-inflammatory activity of the pet ether (PEW) and methanol (MEW) extracts of the leaves of Waltheria indica L. ( Malvaceae ) were evaluated by using in vivo (Carrageenan & histamine induced rat paw edema, cotton pellet granuloma test) models. It was observed that, all the extracts showed significant activity in the in-vivo model at the dose of 500 mg/kg b.w. orally, when compared with control and standard drugs. Of the two extracts tested, methanol extract MEW showed most significant activity well in comparison to the standard drug. Therefore, present study suggests, potential of leaves of Waltheria indica L. in both models of acute and chronic inflammation.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"19 1","pages":"275-278"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90653087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethanolic and Aqueous extract of Leaf of Aloe barbadensis was study, antifertility activity in proven fertile female Wistar Rats at the doses 500mg/kg b.wt./day for 30 days. Different parameters were studied in female wistar rats including effect of Reproductive outcome, Anti-implantation, Abortifacient study and Estrogenic and Anti-estrogenic activity, Phytochemical were observed. , Aloe vera Leaves shown positive test for Alkaloids, Steroid, Flavonoids, Terpene, Carbohydrates and Tannin. The extract of Aloe vera has anti-fertility effect the control rats showed good number of litters. Treatment of animal with different extracts, resulted a significant (P< 0.05, P< 0.01). antifertility activity (42.2% and 7.8%) was exhibited by AAV and WAV respectively. After 21 days of the extracts free period, the antifertility effect of the extracts was reversed. The extract treatments with AAV, an increase in the resorption index (%) by the extract is an indication of failure in the development of the embryo. The mean percentage of anti-implantation and percent resorption (abortifacient) were found to be highest for AAV-29.46%, WAV -12.17, and AAV-32.96%, WAV-7.78% respectively. The decrement in implantation caused by the extracts may be due to estrogenic or anti-estrogenic activity. However, along with standard AAVexhibiting more potent estrogenic and less potent anti-estrogenic when compared with standard.Clinical assessment of Female antifertility agents should include acceptability, safety and efficacy during and after the treatment. The present study was therefore carried out to evaluate the claimed antifertility effect of Aloe vera leaf using different aspects of reproductive physiology in female wistar rats.
{"title":"Pharmacological Evaluation and Antifertility Activity of Aloe barbadensis Linn on female wistar rats.","authors":"S. Shah, D. Jhade, Rajendra Chouksey","doi":"10.5138/09750185.1931","DOIUrl":"https://doi.org/10.5138/09750185.1931","url":null,"abstract":"Ethanolic and Aqueous extract of Leaf of Aloe barbadensis was study, antifertility activity in proven fertile female Wistar Rats at the doses 500mg/kg b.wt./day for 30 days. Different parameters were studied in female wistar rats including effect of Reproductive outcome, Anti-implantation, Abortifacient study and Estrogenic and Anti-estrogenic activity, Phytochemical were observed. , Aloe vera Leaves shown positive test for Alkaloids, Steroid, Flavonoids, Terpene, Carbohydrates and Tannin. The extract of Aloe vera has anti-fertility effect the control rats showed good number of litters. Treatment of animal with different extracts, resulted a significant (P< 0.05, P< 0.01). antifertility activity (42.2% and 7.8%) was exhibited by AAV and WAV respectively. After 21 days of the extracts free period, the antifertility effect of the extracts was reversed. The extract treatments with AAV, an increase in the resorption index (%) by the extract is an indication of failure in the development of the embryo. The mean percentage of anti-implantation and percent resorption (abortifacient) were found to be highest for AAV-29.46%, WAV -12.17, and AAV-32.96%, WAV-7.78% respectively. The decrement in implantation caused by the extracts may be due to estrogenic or anti-estrogenic activity. However, along with standard AAVexhibiting more potent estrogenic and less potent anti-estrogenic when compared with standard.Clinical assessment of Female antifertility agents should include acceptability, safety and efficacy during and after the treatment. The present study was therefore carried out to evaluate the claimed antifertility effect of Aloe vera leaf using different aspects of reproductive physiology in female wistar rats.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"41 1","pages":"253-260"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86484156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Iqbal, M. Jahangir, A. Ullah, M. N. K. Khattak, S. Iqbal
Present study was designed to investigate the effects of 200 mg/ml solvent/Kg of body weight of Bauhinia variegata’s leaf extract on neuromuscular coordination, locomotory and exploratory behavior of adult female albino mice. Six week old female albino mice were used as experimental animals. Mice were either orally supplemented with 200 mg/ml/Kg of body weight Bauhinia variegata’s leaf extract or with saline solution [0.9%] for 7 days. Behavioral observations were made by applying a series of neurological tests [Rota rod, Elevated plus maze, Light and dark box, Open field and Novel object test]. Exploratory and locomotory behavior during Open Field test was improved in leaf extract treated mice as they had more means speed [P = 0.01], rotations [P = 0.001], clockwise rotations [P = 0.004] and anti-clockwise rotations [P = 0.001] than control mice. Bauhinia variegata’s leaf extract treated mice had higher transition frequency [P = 0.002] and spent more time in light compartment during light dark box test than saline treated controls. Bauhinia variegata’s leaf extract treated mice covered more distance [P = 0.033] with higher speed [P = 0.028] compared to control mice during Elevated Plus Maze test. Bauhinia variegata’s leaf extract improves the locomotory and exploratory behavior in adult female albino mice. Leaf extract of Bauhinia variegate can be further explored to be used as a therapeutic agent for the treatment of neurological ailments.
{"title":"Oral supplementations of Bauhinia variegata ’s leaf extract has anxiolytic effect and improves locomotory and exploratory behavior of female albino mice","authors":"F. Iqbal, M. Jahangir, A. Ullah, M. N. K. Khattak, S. Iqbal","doi":"10.5138/09750185.2073","DOIUrl":"https://doi.org/10.5138/09750185.2073","url":null,"abstract":"Present study was designed to investigate the effects of 200 mg/ml solvent/Kg of body weight of Bauhinia variegata’s leaf extract on neuromuscular coordination, locomotory and exploratory behavior of adult female albino mice. Six week old female albino mice were used as experimental animals. Mice were either orally supplemented with 200 mg/ml/Kg of body weight Bauhinia variegata’s leaf extract or with saline solution [0.9%] for 7 days. Behavioral observations were made by applying a series of neurological tests [Rota rod, Elevated plus maze, Light and dark box, Open field and Novel object test]. Exploratory and locomotory behavior during Open Field test was improved in leaf extract treated mice as they had more means speed [P = 0.01], rotations [P = 0.001], clockwise rotations [P = 0.004] and anti-clockwise rotations [P = 0.001] than control mice. Bauhinia variegata’s leaf extract treated mice had higher transition frequency [P = 0.002] and spent more time in light compartment during light dark box test than saline treated controls. Bauhinia variegata’s leaf extract treated mice covered more distance [P = 0.033] with higher speed [P = 0.028] compared to control mice during Elevated Plus Maze test. Bauhinia variegata’s leaf extract improves the locomotory and exploratory behavior in adult female albino mice. Leaf extract of Bauhinia variegate can be further explored to be used as a therapeutic agent for the treatment of neurological ailments.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"19 1","pages":"289-295"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86577228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parkinson disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra, decreased striatal dopamine (DA) levels, and consequent extrapyramidal motor dysfunction. PC 12 cells originate from pheochromocytoma cells of rat adrenal medulla and share many common characteristics with substantia nigra cells. They produce DA, several growth factors, such as nerve growth factor, fibroblast growth factor and transforming growth factor, and express DA receptors. Hence , these cells are being used to study the alterations in dopaminergic neurons, in vitro, that occur during Parkinson’s disease. Since long term usage of antiparkinsonian drugs cause high incidence of pharmacoresistence and untoward side effects, attention has been paid in recent years to screen bioactive compounds from natural medicinal plants for treatment of several neurological disorders including Parkinson’s disease. Keeping in view of relative importance of natural medicinal plants, the present study is mainly focused to characterize the anti-parkinsonian effect of Bacopa monnieri (BM), an Indian herb which is being extensively used in Ayurveda treatments related to neurological complications. The present study was designed to assess the neurotoxicity of rotenone on DA-producing PC12 cells and explore the possible antiparkinsonian effect of BM in comparing with Levodopa (LD) (Reference control). The survivability studies of PC 12 cell-lines were analysed using MTT assay. Pre-treatment with BM extract significantly ameliorated morphological damage, cell viability, and apoptosis of PC12 cells exposed to RT. Hence BM extract can be effectively used in the treatment of PD and other related neurological disorders.
{"title":"Protective role of Bacopa monnieri against Rotenone- induced Parkinson’s disease in PC 12 cell lines","authors":"G. Swathi, Chintha Venkata Ramaiah, W. Rajendra","doi":"10.5138/09750185.2008","DOIUrl":"https://doi.org/10.5138/09750185.2008","url":null,"abstract":"Parkinson disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra, decreased striatal dopamine (DA) levels, and consequent extrapyramidal motor dysfunction. PC 12 cells originate from pheochromocytoma cells of rat adrenal medulla and share many common characteristics with substantia nigra cells. They produce DA, several growth factors, such as nerve growth factor, fibroblast growth factor and transforming growth factor, and express DA receptors. Hence , these cells are being used to study the alterations in dopaminergic neurons, in vitro, that occur during Parkinson’s disease. Since long term usage of antiparkinsonian drugs cause high incidence of pharmacoresistence and untoward side effects, attention has been paid in recent years to screen bioactive compounds from natural medicinal plants for treatment of several neurological disorders including Parkinson’s disease. Keeping in view of relative importance of natural medicinal plants, the present study is mainly focused to characterize the anti-parkinsonian effect of Bacopa monnieri (BM), an Indian herb which is being extensively used in Ayurveda treatments related to neurological complications. The present study was designed to assess the neurotoxicity of rotenone on DA-producing PC12 cells and explore the possible antiparkinsonian effect of BM in comparing with Levodopa (LD) (Reference control). The survivability studies of PC 12 cell-lines were analysed using MTT assay. Pre-treatment with BM extract significantly ameliorated morphological damage, cell viability, and apoptosis of PC12 cells exposed to RT. Hence BM extract can be effectively used in the treatment of PD and other related neurological disorders.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"33 1","pages":"219-222"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86286800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pattharin Wannapruk, Atchara Paemanee, S. Roytrakul, Dalina Tanyong
Leukemia is an uncontrolled proliferation hematopoietic cancer cells that commonly treats with conventional therapies such as chemotherapy. However, many side effects were reported. Alternative medicines have been developed by using natural or herb compounds as therapeutic drug. Sesamin, a class of phytoestrogen isolated from sesame seed displaying potent anticancer activity in vitro and in vivo .However, the mechanism by which sesamin mediates anticancer effects on leukemic cells are notfully understood. In thisstudy, the effects of sesamin on cell viability, cell apoptosis and expression of phosphoproteins in Molt-4 and NB4 leukemic cell lines were investigated using MTT assay, flow cytometry and immobilized metal affinity chromatography (IMAC) phosphoprotein enrichment and LC-MS, respectively. The results showed that sesamin reduced viability and induced apoptosis in leukemic cells. In addition, 79 phosphoproteins were identified from LC-MS within three main clusters including biological regulation, cellular processand metabolic process. Interestingly, nuclear antigen H731 (PDCD4) and CLIP-associating protein 2 isoform X25 (CLASP2) showed increased in sesamin treated cells and associated protein-ligand interaction network with allicin, capsaicin, cucurbitacin B, and rapamycin which are known to activate apoptosis in cancer cells .Then, sesamin could be developed as candidate of alternative leukemia treatment in the future.
{"title":"Anti-leukemic activity of phosphoproteins from Sesamin via induction of nuclear antigen H731and CLIP-associating protein 2 isoform X25 mediated apoptosis","authors":"Pattharin Wannapruk, Atchara Paemanee, S. Roytrakul, Dalina Tanyong","doi":"10.5138/09750185.2078","DOIUrl":"https://doi.org/10.5138/09750185.2078","url":null,"abstract":"Leukemia is an uncontrolled proliferation hematopoietic cancer cells that commonly treats with conventional therapies such as chemotherapy. However, many side effects were reported. Alternative medicines have been developed by using natural or herb compounds as therapeutic drug. Sesamin, a class of phytoestrogen isolated from sesame seed displaying potent anticancer activity in vitro and in vivo .However, the mechanism by which sesamin mediates anticancer effects on leukemic cells are notfully understood. In thisstudy, the effects of sesamin on cell viability, cell apoptosis and expression of phosphoproteins in Molt-4 and NB4 leukemic cell lines were investigated using MTT assay, flow cytometry and immobilized metal affinity chromatography (IMAC) phosphoprotein enrichment and LC-MS, respectively. The results showed that sesamin reduced viability and induced apoptosis in leukemic cells. In addition, 79 phosphoproteins were identified from LC-MS within three main clusters including biological regulation, cellular processand metabolic process. Interestingly, nuclear antigen H731 (PDCD4) and CLIP-associating protein 2 isoform X25 (CLASP2) showed increased in sesamin treated cells and associated protein-ligand interaction network with allicin, capsaicin, cucurbitacin B, and rapamycin which are known to activate apoptosis in cancer cells .Then, sesamin could be developed as candidate of alternative leukemia treatment in the future.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"4 1","pages":"379-388"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72926207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The already available expensive conventional therapies for cancer like chemotherapy and radiotherapy have a number of side effects such as myelosuppression and neurological, cardiac, pulmonary, and renal toxicity, which pose serious harm to the quality of life. Therefore, there is a need to develop treatment options that include more potent and less toxic anticancer drugs as compared to existing drugs. Studies have shown that regular consumption of fruits and vegetables because of phytochemical compounds extracted from them inhibiting the activity of antioxidant and free radicals which in turn showing anti-cancer activities. More recent semi-synthetic analogues of these agents are vinorelbine (VRLB) and vindesine (VDS). These agents are primarily used in combination with other cancer chemotherapeutic drugs for the treatment of a variety of cancers. VLB is used for the treatment of leukaemia, lymphomas, advanced testicular cancer, breast and lung cancers, and Kaposi’s sarcoma, and VCR, in addition to the treatment of lymphomas, also shows efficacy against leukaemia, particularly acute lymphocytic leukaemia in childhood. VRLB has shown activity against non-small-cell lung cancer and advanced breast cancer. Therefore there is need of developing cell cycle-based, mechanism-targeted ancient based modern cancer therapies that emulate the body's natural process in order to stop the growth of cancer cells. This approach can limit the damage to normal cells and the accompanying side effects caused by conventional chemotherapeutic agents. This review focuses on the role of ancient medicine in modern research and anticancer drug development. The current findings and known anticancer agents from natural sources are discussed, and recent therapeutic advances in this field are presented.
{"title":"Need of an Ancient Roots to Modern Medicine in the Treatment of Cancer- A review","authors":"Manish Gunjan, J. R. Naidu, R. Marzo, N. Harmal","doi":"10.5138/09750185.2118","DOIUrl":"https://doi.org/10.5138/09750185.2118","url":null,"abstract":"The already available expensive conventional therapies for cancer like chemotherapy and radiotherapy have a number of side effects such as myelosuppression and neurological, cardiac, pulmonary, and renal toxicity, which pose serious harm to the quality of life. Therefore, there is a need to develop treatment options that include more potent and less toxic anticancer drugs as compared to existing drugs. Studies have shown that regular consumption of fruits and vegetables because of phytochemical compounds extracted from them inhibiting the activity of antioxidant and free radicals which in turn showing anti-cancer activities. More recent semi-synthetic analogues of these agents are vinorelbine (VRLB) and vindesine (VDS). These agents are primarily used in combination with other cancer chemotherapeutic drugs for the treatment of a variety of cancers. VLB is used for the treatment of leukaemia, lymphomas, advanced testicular cancer, breast and lung cancers, and Kaposi’s sarcoma, and VCR, in addition to the treatment of lymphomas, also shows efficacy against leukaemia, particularly acute lymphocytic leukaemia in childhood. VRLB has shown activity against non-small-cell lung cancer and advanced breast cancer. Therefore there is need of developing cell cycle-based, mechanism-targeted ancient based modern cancer therapies that emulate the body's natural process in order to stop the growth of cancer cells. This approach can limit the damage to normal cells and the accompanying side effects caused by conventional chemotherapeutic agents. This review focuses on the role of ancient medicine in modern research and anticancer drug development. The current findings and known anticancer agents from natural sources are discussed, and recent therapeutic advances in this field are presented.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"11 1","pages":"195-206"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78968594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present study was designed to study the effect of water stress on Lycopersicon esculentum Mill. and role of sodium silicate in the protection of tomato plants under water deficit condition. Different biochemical parameters such as photosynthetic pigments, protein, sugar, MDA content, proline, nitrate reductase activity and activities of antioxidant enzymes (SOD, CAT, APX and POX) were examined in tomato leaves at 40 and 60 DAS by the standard methods. The lycopene and β-carotene contents in tomato fruits were also analyzed at 60, 65 and 70 DAS. Water stress significantly decreased relative water content (RWC), pigment content, sugar and protein contents in tomato leaves at 60 DAS but the accumulation of proline was stimulated in tomato leaves under water deficit condition. The activities of antioxidant enzymes such as SOD, CAT, APX and POX were significantly increased under (3d and 6d) water stress condition at 60 DAS. This study offers first hand information on the water stress-induced oxidative stress in Lycopersicon esculentum and development of antioxidative defense system against drought. The results obtained clearly indicated the positive impact of sodium silicate in protection of tomato plants under water deficit condition.
{"title":"Sodium silicate mediated response of antioxidative defense system in Lycopersicon esculentum mill. under water stress","authors":"C. Malhotra, R. Kapoor, D. Ganjewala, Nb Singh","doi":"10.5138/09750185.2108","DOIUrl":"https://doi.org/10.5138/09750185.2108","url":null,"abstract":"The present study was designed to study the effect of water stress on Lycopersicon esculentum Mill. and role of sodium silicate in the protection of tomato plants under water deficit condition. Different biochemical parameters such as photosynthetic pigments, protein, sugar, MDA content, proline, nitrate reductase activity and activities of antioxidant enzymes (SOD, CAT, APX and POX) were examined in tomato leaves at 40 and 60 DAS by the standard methods. The lycopene and β-carotene contents in tomato fruits were also analyzed at 60, 65 and 70 DAS. Water stress significantly decreased relative water content (RWC), pigment content, sugar and protein contents in tomato leaves at 60 DAS but the accumulation of proline was stimulated in tomato leaves under water deficit condition. The activities of antioxidant enzymes such as SOD, CAT, APX and POX were significantly increased under (3d and 6d) water stress condition at 60 DAS. This study offers first hand information on the water stress-induced oxidative stress in Lycopersicon esculentum and development of antioxidative defense system against drought. The results obtained clearly indicated the positive impact of sodium silicate in protection of tomato plants under water deficit condition.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"86 1","pages":"364-378"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85474360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.
{"title":"Algae as potential repository of anti cancerous natural compounds","authors":"A. Mridha, Santanu Paul","doi":"10.5138/09750185.2023","DOIUrl":"https://doi.org/10.5138/09750185.2023","url":null,"abstract":"Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"7 17 1","pages":"181-194"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83492884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Oršolić, Vedran Balta, Dyana Odeh, Maja Mataković, J. Skurić
Reactive oxygen species (ROS) play a role in a numbered of degenerative conditions including psoriasis. Psoriasis is a chronic inflammatory disease who’s the etiopathogenesis is not yet completely understood, and therefore there is no standardized therapeutical approach. Flavonoids, recognized as potent antioxidants, are multifunctional molecules that can act as anti-inflammatory and antiproliferative agents through the modulation of multiple signaling pathways. The present study was designed to investigate the protective role of flavonoids [quercetin, chrysin, curcumin or Epigallocatechin 3-gallate (EGCG)] against n-Hexyl salicylate (HXS)-induced oxidative stress and inflammation in skin. Anti-oxidative and anti-inflammatory effect of flavonoids is quantified by histopathological assessment of skin, measuring the levels of lipid peroxidation and glutathione (GSH) in the skin, total number of inflammatory cells in peritoneal cavity, macrophage spreading index, and hematological and biochemical parameters. Topically applied of n-Hexyl salicylate caused significant increase in lipid peroxidation and decrease in GSH, which is accompanied by an increase total number of inflammatory cells in skin and peritoneal cavity, functional activity of macrophages, and enzymatic activity of ALP and AST. In contrast, topically applied 5 % preparation of flavonoids (quercetin, chrysin, curcumin or EGCG) with HXS effectively prevented these alterations and maintained the antioxidant status. The results suggest that flavonoid preparations can serve as a potent antioxidant and anti-inflammatory agents in psoriatic-like skin lesions, without toxic effects.
{"title":"Oxidative stress and inflammation caused by n- hexyl salicylate in mouse skin: the effectiveness of flavonoids","authors":"N. Oršolić, Vedran Balta, Dyana Odeh, Maja Mataković, J. Skurić","doi":"10.5138/09750185.2064","DOIUrl":"https://doi.org/10.5138/09750185.2064","url":null,"abstract":"Reactive oxygen species (ROS) play a role in a numbered of degenerative conditions including psoriasis. Psoriasis is a chronic inflammatory disease who’s the etiopathogenesis is not yet completely understood, and therefore there is no standardized therapeutical approach. Flavonoids, recognized as potent antioxidants, are multifunctional molecules that can act as anti-inflammatory and antiproliferative agents through the modulation of multiple signaling pathways. The present study was designed to investigate the protective role of flavonoids [quercetin, chrysin, curcumin or Epigallocatechin 3-gallate (EGCG)] against n-Hexyl salicylate (HXS)-induced oxidative stress and inflammation in skin. Anti-oxidative and anti-inflammatory effect of flavonoids is quantified by histopathological assessment of skin, measuring the levels of lipid peroxidation and glutathione (GSH) in the skin, total number of inflammatory cells in peritoneal cavity, macrophage spreading index, and hematological and biochemical parameters. Topically applied of n-Hexyl salicylate caused significant increase in lipid peroxidation and decrease in GSH, which is accompanied by an increase total number of inflammatory cells in skin and peritoneal cavity, functional activity of macrophages, and enzymatic activity of ALP and AST. In contrast, topically applied 5 % preparation of flavonoids (quercetin, chrysin, curcumin or EGCG) with HXS effectively prevented these alterations and maintained the antioxidant status. The results suggest that flavonoid preparations can serve as a potent antioxidant and anti-inflammatory agents in psoriatic-like skin lesions, without toxic effects.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"22 1","pages":"279-288"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86366733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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