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Amifampridines (3,4 Diaminopyridine and 3,4 Diaminopyridine Phosphate): Drugs of Choice for Lambert-Eaton Myasthenic Syndrome 氨苯丙啶(3,4二氨基吡啶和3,4磷酸二氨基吡啶):兰伯特-伊顿肌无力综合征的首选药物
Pub Date : 2021-01-01 DOI: 10.35248/2329-9096.21.S4.005
Shin J Oh
Amifampridines have been known to be effective as symptomatic treatment of Lambert-Eaton myasthenic syndrome since 1983. Food Drug Administration (FDA) approved amifampridines, the most studied safe and effective drugs in the neuromuscular diseases, are available for the general use for symptomatic treatment of LEMS, 60 years after the first description of LEMS and 40 years after the first trial of 3,4-DAP in LEMS.
自1983年以来,阿米福定被认为是有效的兰伯特-伊顿肌无力综合征的对症治疗。amifampri定是美国食品药品监督管理局(FDA)批准的神经肌肉疾病中研究最多的安全有效的药物,在LEMS首次描述60年后,在3,4- dap在LEMS中的首次试验40年后,可用于LEMS的一般对症治疗。
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引用次数: 0
Application of Shear Wave Elastography in Diagnosing Tendinopathies 横波弹性成像在肌腱病变诊断中的应用
Pub Date : 2021-01-01 DOI: 10.35248/2329-9096.21.S4.002
Sarah E. Playford, L. Hackett, George Ac Murell
Supraspinatus tendinopathy is a common cause of shoulder pain and tendon degeneration in individuals who participate in repetitive overhead activities, such as tennis players or tradespeople. Early diagnosis and treatment of tendinopathies is necessary to prevent chronic sequelae and tendon rupture, which is especially important for groups such as professional athletes and manual workers for avoidance of prolonged downtime.
冈上肌肌腱病变是参与重复性头顶活动的个体(如网球运动员或商人)肩膀疼痛和肌腱变性的常见原因。肌腱病变的早期诊断和治疗对于预防慢性后遗症和肌腱断裂是必要的,这对于专业运动员和体力劳动者等群体尤其重要,以避免长时间的停工。
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引用次数: 0
Study on the Effect of Web-Based Real-Time Interactive Intervention Teaching Model on Self-Efficacy of Gestational Diabetes Mellitus Patients 基于web的实时互动干预教学模式对妊娠期糖尿病患者自我效能感的影响研究
Pub Date : 2020-11-30 DOI: 10.4236/ijcm.2020.1112058
Yu Yang, Qiuying Lin, Pingping Quan, Yanmei Wen, Xuyao Li, Jufang Lin
Object: To explore the effect of web-based real-time interactive intervention teaching model on self-efficacy of Gestational Diabetes Mellitus (GDM) patients. Method: Based on the hospital’s antenatal check-up archives from June 2018 to January 2019, patients diagnosed with GDM in the second trimester were randomly divided into the control group (100 cases) and the experimental group (121 cases). Patients in the control group received routine care following the diabetes mellitus one-day outpatient guidance, while patients in the experimental group received social media real-time interactive teaching intervention based on routine care, and accepted a nursing intervention scheme based on knowledge-attitude-practice mode. The knowledge of GDM, self-efficacy and self-management behavior indicators were compared between the two groups. Results: After the intervention, the self-efficacy scores, the blood glucose monitoring times and the blood glucose compliance rates of the experimental group were significantly higher than those of the control group (P P = 0.072). Conclusion: Web-based real-time interactive intervention teaching model can effectively improve the self-efficacy of GDM patients and promote the formation of healthy behaviors.
目的:探讨基于网络的实时互动干预教学模式对妊娠糖尿病(GDM)患者自我效能感的影响。方法:根据该院2018年6月至2019年1月的产前检查档案,将诊断为妊娠中期GDM的患者随机分为对照组(100例)和实验组(121例)。对照组患者在糖尿病一日门诊指导下进行常规护理,实验组患者在常规护理基础上进行社交媒体实时互动教学干预,并采用基于知识-态度-实践模式的护理干预方案。比较两组患者GDM知识、自我效能感、自我管理行为指标。结果:干预后,实验组患者自我效能感评分、血糖监测次数及血糖依从率均显著高于对照组(P P = 0.072)。结论:基于网络的实时互动干预教学模式能有效提高GDM患者的自我效能感,促进健康行为的形成。
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引用次数: 1
Role of Pre-Operative of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratio in Prognosis of Hepatocellular Carcinoma 术前中性粒细胞/淋巴细胞及血小板/淋巴细胞比值对肝癌预后的影响
Pub Date : 2020-08-28 DOI: 10.4236/ijcm.2020.119042
C. Ker, Hong-Yi Tong, Ming-Yuen Yang, I. Tseng, Der-Ming Chang, hong-Yaw Chen, Bowei Wang, C. Ko, C. Chao, Yu-Fu Chen
Introduction: Hepatocellular carcinoma (HCC) has a poor prognosis and is ranked in the top 2 leading causes of death in Taiwan. The clinical features which affect survival rate should be noticed for alarming. We tried to study the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) for the predictor of prognosis of HCC. Patients and Methods: A total of 525 patients with HCC were undergone surgical or non-surgical treatment registered in Cancer Registry Center of our hospital. The clinical features included patient’s basic profiles, and neutrophil, lymphocyte and platelet count in the peripheral blood at the time of diagnosis. The ratio of neutrophil/lymphocyte and platelate/lymphocyte was measured and their survival rates were analyzed based on their ratio scales. Results: Three scales of NLR and PLR were ≤1.62, 1.63 - 2.57, ≥2.58 and ≤224, 225 - 253, ≥254 respectively. Either higher NLR ≥ 2.58 or higher PLR ≥ 254 was found mostly in the male and TMN stage III and IV with a significant difference (P < 0.01). The 5-year survival rates of NLR ≤ 1.62, 1.63 - 2.57, ≥2.58 were 33.9%, 33.7%, and 16.7% respectively (P < 0.001). The mean survival times were 34.1 ± 1.4, 29.3 ± 8.1, and 14.2 ± 2.1 months for the scales of PLR ≤ 224, 225 - 253, and ≥ 254 respectively. The 5-year survival rates were 25.5%, 36.4%, and 7.7% for the groups of the PLR ≤ 224, 225 - 253, and ≥254 respectively (p < 0.001). Conclusion: Neutrophil, lymphocyte and platelet are players in cancer growth and have a potential role as predictors of survival in our HCC patients. Therefore, we should pay more attention to the higher NLR or PLR which will result in a poorer prognosis in our patients.
简介:肝细胞癌(HCC)预后不良,是台湾排名前2位的主要死亡原因。影响生存率的临床特征应引起重视,引起警惕。我们试图研究中性粒细胞-淋巴细胞比率(NLR)和血小板-淋巴细胞比率(PLR)对HCC预后的预测作用。患者与方法:525例肝癌患者在我院肿瘤登记中心接受手术或非手术治疗。临床特征包括患者基本概况,诊断时外周血中性粒细胞、淋巴细胞和血小板计数。测定中性粒细胞/淋巴细胞和血小板/淋巴细胞的比值,并根据比值量表分析其存活率。结果:NLR和PLR量表分别≤1.62、1.63 ~ 2.57、≥2.58和≤224、225 ~ 253、≥254。NLR≥2.58或PLR≥254以男性和TMN III期、IV期患者居多,差异有统计学意义(P < 0.01)。NLR≤1.62、1.63 ~ 2.57、≥2.58的5年生存率分别为33.9%、33.7%、16.7% (P < 0.001)。PLR≤224、225 ~ 253、≥254评分的平均生存时间分别为34.1±1.4、29.3±8.1、14.2±2.1个月。PLR≤224、225 ~ 253和≥254组的5年生存率分别为25.5%、36.4%和7.7% (p < 0.001)。结论:中性粒细胞、淋巴细胞和血小板在肝癌患者的肿瘤生长中起着重要作用,并可能作为肝癌患者生存的预测因子。因此,我们应该更加重视NLR或PLR过高会导致我们的患者预后较差。
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引用次数: 0
Impact of Oxaliplatin-Induced Neuropathy on Subsequent Paclitaxel for Advanced Gastric Cancer 奥沙利铂诱导的神经病变对晚期胃癌紫杉醇治疗的影响
Pub Date : 2020-08-28 DOI: 10.4236/ijcm.2020.119045
J. Sato, S. Iwasa, Y. Honma, A. Takashima, N. Okita, Ken Kato, T. Hamaguchi, Y. Yamada, N. Boku
Purpose: Several studies have shown that fluoropyrimidine plus oxaliplatin (SOX) is non-inferior to fluoropyrimidine plus cisplatin as first-line chemotherapy for advanced gastric cancer. We investigated retrospectively the choice of second-line regimen, along with the proportion and feasibility of paclitaxel-containing regimen, in the subsequent treatment of patients with advanced gastric cancer treated with SOX as first-line chemotherapy. Materials and Methods: We retrospectively analyzed the impact of oxaliplatin-induced neuropathy on both the choice of subsequent regimens and feasibility of subsequent chemotherapy with paclitaxel, focusing on patients with advanced gastric cancer who received S-1 plus oxaliplatin as first-line chemotherapy. Results: Twenty-seven from a total of 31 patients enrolled into the phase 2 and phase 3 study assessing S-1 plus oxaliplatin were analyzed (4 patients were deemed ineligible). Among 24 patients that had received second-line treatment, paclitaxel was not selected in 2 patients due to oxaliplatin-induced neuropathy. Paclitaxel was selected as second-line chemotherapy in 16 patients, as third-line chemotherapy in 6 patients and fourth-line chemotherapy in one patient. Severity of sensory neuropathy was grade 0/1/2/3 in 11/10/2/0 patients, respectively, immediately before treatment with paclitaxel, while the worst toxicity profile during paclitaxel treatment was grade 0/1/2/3 in 7/13/1/2 patients, respectively. Although there were no patients requiring dose reductions of paclitaxel due to neuropathy, 2 patients discontinued paclitaxel use due to grade 3 sensory neuropathy after 4 or 8 administrations of paclitaxel. Conclusion: Oxaliplatin-induced neuropathy during first-line chemotherapy may affect the choice and feasibility of subsequent chemotherapy with paclitaxel in advanced gastric cancer patients.
目的:多项研究表明,氟嘧啶联合奥沙利铂(SOX)作为晚期胃癌一线化疗方案的疗效不低于氟嘧啶联合顺铂。我们回顾性探讨以SOX为一线化疗的晚期胃癌患者后续治疗中二线方案的选择,以及含紫杉醇方案的比例和可行性。材料与方法:回顾性分析奥沙利铂诱导的神经病变对后续方案选择及后续紫杉醇化疗可行性的影响,以S-1 +奥沙利铂一线化疗的晚期胃癌患者为研究对象。结果:共有31名患者参加了评估S-1 +奥沙利铂的2期和3期研究,分析了27名患者(4名患者被认为不合格)。在24例接受二线治疗的患者中,有2例患者由于奥沙利铂引起的神经病变而未选择紫杉醇。16例患者选择紫杉醇作为二线化疗,6例患者选择三线化疗,1例患者选择四线化疗。在接受紫杉醇治疗前,11/10/2/0患者感觉神经病变的严重程度分别为0/1/2/3级,而紫杉醇治疗期间最严重的毒性分别为7/13/1/2患者0/1/2/3级。虽然没有患者因神经病变而需要减少紫杉醇的剂量,但有2例患者在服用紫杉醇4或8次后因3级感觉神经病变而停止使用紫杉醇。结论:奥沙利铂所致的一线化疗神经病变可能影响晚期胃癌患者后续紫杉醇化疗的选择和可行性。
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引用次数: 1
Perioperative Nursing for Adult Congenital Heart Disease with Severe Pulmonary Arterial Hypertension 成人先天性心脏病合并重度肺动脉高压的围手术期护理
Pub Date : 2020-08-28 DOI: 10.4236/ijcm.2020.119046
Shunling Li, S. Liang, Weihua Xue
Objectives: To explore the main points of perioperative nursing for adult congenital heart disease with severe pulmonary arterial hypertension. Methods: A retrospective study of 13 patients with congenital heart disease and severe pulmonary arterial hypertension who admitted to the perioperative period of care from January 2018 to December 2019. To prevent perioperative complications of the patients, the focus is on respiratory and circulatory system care, followed by blood coagulation monitoring, digestive system protection and psychological care. Results: All 13 patients passed the perioperative period and were discharged from ICU. Conclusion: Adult congenital heart disease with severe pulmonary arterial hypertension has high perioperative risk, respiratory and circulatory system care is the key.
目的:探讨成人先天性心脏病合并重度肺动脉高压围手术期护理要点。方法:对2018年1月至2019年12月围手术期收治的13例先天性心脏病合并重度肺动脉高压患者进行回顾性分析。为预防患者围手术期并发症的发生,重点是呼吸循环系统护理,其次是凝血监测、消化系统保护和心理护理。结果:13例患者均顺利度过围手术期,出院。结论:成人先天性心脏病合并重度肺动脉高压围手术期风险高,呼吸循环系统护理是关键。
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引用次数: 0
Application and Nursing of Pulse Index Continuous Cardiac Output (PiCCO) Volume Monitoring in Early Fluid Resuscitation in Patients with Septic Shock 脉搏指数连续心输出量(PiCCO)监测在感染性休克患者早期液体复苏中的应用及护理
Pub Date : 2020-08-06 DOI: 10.4236/ijcm.2020.118041
Shunling Li, S. Liang, Weihua Xue
Background: Septic shock is a rapidly changing and fatal syndrome that can cause comprehensive deterioration of cardiopulmonary and renal function and multiple organ failure. At the same time, septic shock has the complex clinical manifestations and hemodynamics. PiCCO can accurately monitor blood flow, physical and volume indicators, and active and effective fluid resuscitation are important measures to reduce the fatality rate of septic shock and improve the prognosis of patients. Objectives: To explore the application and nursing of PiCCO in early fluid resuscitation in patients with septic shock. Methods: This was a retrospective observational study. The observation group and the control group each had 30 cases. The observation group used PiCCO to guide fluid resuscitation; the control group used conventional methods to guide fluid resuscitation. The changes in CVP, HR, MAP, and urine volume per hour were observed in the two groups. The changes of various indicators before and after fluid resuscitation, the length of stay in ICU and the mortality rate were compared between the two groups. All the outcomes were collected from the electronic medical case system after patients’ discharge from the hospital. Results: APACHE II, CVP, HR, MAP were compared between the observation group and the control group, and the differences were statistically significant (P 0.05). The blood volume of patients in the observation group was significantly improved after fluid supplementation (P 0.05). Compared with the control group, the length of stay in ICU in the observation group was significantly shorter, and the mortality rate was also significantly reduced (P 0.05). Conclusion: PiCCO can be better used in early fluid resuscitation of patients with septic shock.
背景:感染性休克是一种瞬息万变的致死性综合征,可引起心肺、肾功能全面恶化和多器官功能衰竭。同时,感染性休克具有复杂的临床表现和血流动力学。PiCCO能准确监测血流、生理及容积指标,积极有效的液体复苏是降低脓毒性休克病死率、改善患者预后的重要措施。目的:探讨PiCCO在感染性休克患者早期液体复苏中的应用及护理。方法:回顾性观察性研究。观察组和对照组各30例。观察组采用PiCCO指导液体复苏;对照组采用常规方法指导液体复苏。观察两组患者CVP、HR、MAP、每小时尿量的变化。比较两组患者液体复苏前后各项指标变化、ICU住院时间及死亡率。所有结果均收集自患者出院后的电子病例系统。结果:观察组与对照组APACHEⅱ、CVP、HR、MAP比较,差异均有统计学意义(P < 0.05)。观察组患者补液后血容量明显改善(P < 0.05)。与对照组比较,观察组患者在ICU的住院时间明显缩短,病死率也明显降低(P < 0.05)。结论:PiCCO可较好地用于感染性休克患者的早期液体复苏。
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引用次数: 0
Uncertainty of Clinical Thinking and Patient Safety 临床思维的不确定性与患者安全
Pub Date : 2020-08-06 DOI: 10.4236/ijcm.2020.118040
Qian Zhao, Zhang-shun Shen, Hui Guo, Jian-Guo Li
Clinical thinking have the uncertainty, by which there are not a few mistakes caused. So it is necessary to discuss how to deal with the uncertainty of clinical thinking, which originates from the uncertainty of the objective world, social world and medicine knowledge, and can be seen all over clinical activities; Critical thinking which cautious about the interpretation and prediction of scientific theory is the best practice to explore the uncertainty. The essential purpose of medicine is rescuing people, So it is necessary and scientific to take “excluding life-threatening symptoms first” as the first principle of clinical thinking, which is also the primary method to deal with the uncertainty of clinical thinking; By the limited certainty of clinical thinking, procedural thinking is conducive to building a safer health system that is “easy to do right and difficult to do wrong”.
临床思维具有不确定性,由此造成的失误也不少。临床思维的不确定性来源于客观世界、社会世界和医学知识的不确定性,并贯穿于临床活动的各个方面,因此如何应对临床思维的不确定性就显得十分必要;批判性思维对科学理论的解释和预测持谨慎态度,是探索不确定性的最佳实践。医学的根本目的是救人,因此将“排除危及生命的症状”作为临床思维的第一原则是必要的和科学的,这也是处理临床思维不确定性的主要方法;程序性思维利用临床思维有限的确定性,有利于构建“易对难错”的安全卫生体系。
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引用次数: 1
Rhomboid Flap vs. Keystone Perforator Island Flap (KPIF) in the Treatment of Pilonidal Sinus Disease: Comparison of Short-Term Results 菱形皮瓣与楔石穿支岛状皮瓣治疗毛毛窦疾病的近期疗效比较
Pub Date : 2020-07-14 DOI: 10.4236/ijcm.2020.117038
Marius D. Roatis, A. Georgescu
Background: Pilonidal disease is a chronic inflammatory disease of the sacrococcygeal region that mainly affects young people. Its incidence is 26 cases per 100,000 persons. Although many techniques have been described, there is no consensus on the treatment of pilonidal sinus disease (PSD). Materials and Methods: This study included 30 patients with PSD who were treated between May 2014 and September 2017. All cases underwent excision and flap reconstruction. The operative time, postoperative complications, the length of hospital stay, painless sitting and walking time, patient satisfaction and recurrence were evaluated prospectively. Results: The results of this prospective, randomized and comparative study are based on experience of a single surgical centre. All patients were followed up 18 months after discharge from the hospital. There is a difference in surgery durations (minutes) between the two groups (33.86 ± 2.89 min. in “keystone” flap vs. 41.26 ± 4.19 in the “rhombic” flap group) (p = 0.001). There were no significant differences in the length of hospital stay, painless sitting and walking time or patient satisfaction. The total complication rate was 66.6% after rhomboid flap compared with 6.6% after keystone flap. There was no flap necrosis. Conclusions: Both of these methods have shown to be successful in treatment of PSD. The KPIF is associated with the advantages of very simple design, abundant blood supply from the perforator vessels and lower rate of complication.
背景:毛鞘病是一种主要影响年轻人的骶尾骨区慢性炎症性疾病。发病率为每10万人26例。虽然许多技术已经描述,没有共识的治疗毛毛窦疾病(PSD)。材料与方法:本研究纳入了2014年5月至2017年9月期间接受治疗的30例PSD患者。所有病例均行手术切除及皮瓣重建。对手术时间、术后并发症、住院时间、无痛坐行时间、患者满意度及复发率进行前瞻性评价。结果:这项前瞻性,随机和比较研究的结果是基于单一手术中心的经验。所有患者出院后随访18个月。两组手术时间(分钟)差异(楔型皮瓣33.86±2.89分钟vs菱形皮瓣41.26±4.19分钟)(p = 0.001)。在住院时间、无痛静坐和行走时间或患者满意度方面没有显著差异。菱形瓣术后总并发症发生率为66.6%,楔状瓣术后总并发症发生率为6.6%。无皮瓣坏死。结论:两种方法均可成功治疗PSD。KPIF具有设计简单、穿支血管供血充足、并发症发生率低等优点。
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引用次数: 1
Parametrization of Survival Measures (Part II): Single Arm Studies 生存措施的参数化(第二部分):单组研究
Pub Date : 2020-05-27 DOI: 10.4236/ijcm.2020.115032
A. Szász, G. Szigeti, M. Szász
In some clinical applications in oncology randomized, double armed, and double-blind trials are not possible. In case of device applications, double-blinded conditions are nonrealistic, and with many times the randomization also has complications due to the high-line treatments where the reference cohort is not available; the active “arm” has mainly palliative initiative. Sometimes highly personalized therapies block the collection of the homogeneous group and limit its double-arm randomization. Our objective is to discuss the situations of the single arm evaluation and to give methods for the mining of information from this to increase the level of evidence of the measured dataset. The basic idea of the data-separation is the appropriate parameterization of the non-parametric Kaplan-Meier survival pattern by the poly-Weibull fit.
在肿瘤学的一些临床应用中,不可能进行随机、双臂和双盲试验。在设备应用的情况下,双盲条件是不现实的,并且由于没有参考队列的高线治疗,随机化也有很多并发症;活跃的“手臂”主要具有姑息性。有时,高度个性化的治疗会阻碍同质组的收集,并限制其双臂随机化。我们的目标是讨论单臂评估的情况,并给出从中挖掘信息的方法,以提高测量数据集的证据水平。数据分离的基本思想是通过poly-Weibull拟合对非参数Kaplan-Meier生存模式进行适当的参数化。
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引用次数: 2
期刊
International Journal of Physical Medicine and Rehabilitation
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