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An investigation of cellular immunity in DMBA induced hamster's tongue neoplasia formation. I. Delayed type hypersensitivity reaction in dinitrochlorobenzene of hamsters.:I. Delayed type hypersensitivity reaction in dinitrochlorobenzene of hamsters DMBA诱导的仓鼠舌瘤形成的细胞免疫研究。1 .仓鼠对二硝基氯苯的延迟型超敏反应。二硝基氯苯对仓鼠的延迟型超敏反应
Pub Date : 1985-04-20 DOI: 10.5794/JJOMS.31.731
Y. Shigeta, N. Sakai, Y. Tanakura, T. Ohya, N. Akazawa, M. Ohnishi, H. Ishida, Koichi Nakanishi, K. Shimada
Through the use of 119 3-month-old male hamsters the DNCB delayed type hypersensitivity (DTH) reactions to radiation exposure, doses of anticarcinoagents, and steroids on both normal hamsters and DMBA induced hamsters with tongue neoplasia were examined.Skin of the hamsters' hind liras were sensitized with injections of 5% DNCB-Freund's Incomplete Adjuvant suspension 0.1ml below the skin. One week following the sensitization the skin of each hamster's abdomen was tonsured and comparative challeng testw ere conducted by performing one patch test of 0.5% DNCB acetone solution and another of 0.1ml saline solution for purposes of comparison. The tested portions were then examined 24 hours later.On the untreated normal hamster's DNCB-DTH reactions, 94.9% were positive. The DMBA treated group's DNCB-DTH reactions after the prescribed amount of time had elasped, rose from 90% to 94. 7%. From these results it was surmised that positive-DNCB-DTH reactions were recognized in the DMBA sensitized, DNCB tested hamster group and that an antigeneicity common to both DMBA and DNCB existed. This showed the difficulty investigating degrees of cellular immunity through the DTH reactions of DNCB in the DMBA carcinogenic experimental group.For 14 consecutive days Hydrocorcisone sodium succinate 10mg/kg, Predonisolone sodium succinate 6mg/kg, Cyclophosphamide 20mg/kg, and Tegaful 100mg/kg were injectedinto the peritoneal cavities of normal hamsters which recieved sensitization on the seventh day. On the fourteenth day test results proved that the positive DNCB-DTH reactions had not been decreased.However, the decreas on DNCB-DTH reactions was recognized in the portion of the group which recieved radiation exposure (6 MeV, X-Ray 300 rad, single full body exposure) prior to, and following sensitization.
通过使用119只3月龄雄性仓鼠,研究了DNCB延迟型超敏反应(DTH)对正常仓鼠和DMBA诱发的舌瘤鼠的辐射暴露、抗癌药物和类固醇剂量的影响。将5% DNCB-Freund's不完全佐剂混悬液注射于皮肤下0.1ml,致敏仓鼠后肝皮肤。致敏1周后,对每只仓鼠腹部皮肤进行测肤,并进行对照激射试验,分别用0.5% DNCB丙酮溶液和0.1ml生理盐水溶液进行一次斑贴试验进行比较。然后在24小时后检查测试部分。未处理的正常仓鼠DNCB-DTH反应阳性率为94.9%。DMBA治疗组的dcb - dth反应在规定时间内发生弹性后,从90%上升到94%。7%。从这些结果推测,在DMBA致敏和DNCB测试的仓鼠组中,DNCB- dth阳性反应被识别,并且DMBA和DNCB存在共同的抗原性。这表明在DMBA致癌实验组中,通过DNCB的DTH反应来研究细胞免疫程度的困难。正常仓鼠腹腔内连续注射氢化松酮琥珀酸钠10mg/kg、强的松龙琥珀酸钠6mg/kg、环磷酰胺20mg/kg、泰加力100mg/kg,第7天致敏。第14天的检测结果表明,DNCB-DTH阳性反应并没有减少。然而,在致敏前和致敏后接受辐射暴露(6兆电子伏,x射线300 rad,单全身暴露)的部分人群中,DNCB-DTH反应有所减少。
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引用次数: 1
The Hajdu-Cheney syndrome Hajdu-Cheney综合症
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80082-X
B.R. Van Den Houten , L.P. Ten Kate , J.C. Gerding

The Hajdu-Cheney syndrome or acro-osteolysis syndrome is a rare disease. Only 18 well-documented cases are described in the literature. Presentation of cases in the oral surgical literature is rare. The syndrome is characterized by dissolution of terminal phalanges of the hands and feet, dolichocephaly, open cranial sutures, multiple wormian bones, absence of frontal sinuses, wide open sella turcica, progressive basilar invagination, early loss of teeth, short stature and characteristic facies. Inheritance is most likely autosomal dominant. 3 patients are presented, 2 of them are mother and son, the latter (case 2) being the youngest patient reported to date. The parents of the 3rd patient were consanguineous, raising the possibility of genetic heterogeneity. Dental, surgical and genetic aspects are discussed.

Hajdu-Cheney综合征或肢端骨溶解综合征是一种罕见的疾病。文献中只描述了18个有充分记录的病例。在口腔外科文献中,病例的呈现是罕见的。该综合征的特点是手足端指骨溶解,头状畸形,颅缝开放,多根虫状骨,额窦缺失,蝶鞍大开口,颅底进行性内陷,早期牙齿脱落,身材矮小和特征相。遗传最可能是常染色体显性。3例患者,其中2例为母子,后者(病例2)是迄今为止报道的最年轻的患者。第三例患者父母系近亲,可能存在遗传异质性。牙科,外科和遗传方面的讨论。
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引用次数: 28
Fractures of the coronoid process of the mandible 下颌骨冠突骨折
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80083-1
Alexander D Rapidis , Demetrius Papavassiliou, John Papadimitriou, John Koundouris, Nicholas Zachariadis

Fractures of the coronoid process occur infrequently. In the present study, 52 cases of fracture of the coronoid process are presented and analysed and the relèvent literature is reviewed. Coronoid fractures constituted 2.9% of all facial fractures. Of the 52 cases, 12 were isolated coronoid fractures (23%), whereas in the remaining 40 cases, coronoid fractures coexisted with other maxillofacial injuries. The clinical picture, diagnosis and therapeutic modalities of coronoid fractures are discussed.

冠突骨折并不常见。本文报道并分析了52例冠突骨折病例,并对相关文献进行了复习。冠状面骨折占面部骨折总数的2.9%。52例中,单纯冠状面骨折12例(23%),其余40例冠状面骨折合并其他颌面损伤。本文讨论了冠状突骨折的临床表现、诊断和治疗方法。
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引用次数: 29
Autotransplantation of human premolars 人类前磨牙的自体移植
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80093-4
Lars Kristerson

The purpose of the present study was to identify factors which might influence the success of autotransplantion, such as root development, root resorption, pulp condition and tooth eruption. The material consisted of 100 human premolars transplanted in 87 patients. The observation period ranged from 3–18 years, with a mean value 6.3 years. Clinical and radiographic examinations were performed. The transplanted premolars were divided into 7 stages of root development. At the final control, 93 teeth remained and 7 teeth were extracted. Periodontal healing without root resorption was related to stage of root development. It decreased from 93% in teeth with ¾ root development to 37% in teeth with fully developed roots. Inflammatory root resorption was seen in 7 cases and replacement root resorption in 12 cases. Pulp revascularization was observed in 100% in stages with initial root development to ½ root development and decreased to 0% for teeth with fully developed roots. Pulp obliteration was observed in all cases with revascularized pulp tissue. The gingival condition was similar to contralateral, not transplanted premolars or adjacent teeth. Root growth increased with the stage of root development at the time of transplantation.

It is concluded that transplantation of premolars with ½–¾ root development provides a good chance of pulp survival, limited risk of root resorption and ensures sufficient final root length, and is thus recommended.

本研究的目的是探讨影响自体移植成功的因素,如牙根发育、牙根吸收、牙髓状况和牙萌出等。该材料由87例患者移植的100颗人前磨牙组成。观察期3 ~ 18年,平均6.3年。进行了临床和影像学检查。移植前磨牙的根发育分为7个阶段。在最终对照时,保留牙93颗,拔除牙7颗。牙周愈合无根吸收与牙根发育阶段有关。从牙根发育3 / 4的牙齿的93%下降到牙根完全发育的牙齿的37%。炎性根吸收7例,置换根吸收12例。牙髓血运重建率在牙根发育初期至半根发育阶段为100%,而在牙根发育完全的牙髓血运重建率为0%。所有有血管重建的牙髓组织均出现牙髓闭塞。牙龈状况与对侧未移植前磨牙或邻牙相似。根系生长随移栽时根系发育阶段的增加而增加。结论:1 / 2 ~ 3 / 4根发育的前磨牙移植具有良好的牙髓存活机会、有限的根吸收风险和足够的终根长度,因此推荐进行移植。
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引用次数: 177
Anesthesia and analgesia 麻醉与镇痛
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80096-X
Søren Hillerup
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引用次数: 0
Cherubism Cherubism。
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80085-5
Nicholas Zachariades , Stavros Papanicolaou, Assimina Xypolyta, Ioannis Constantinidis

Cherubism is a benign, hereditary giant cell lesion of the jaws, that appears in children as a bilateral painless swelling, between the ages of 2 and 5 years and progresses until puberty, when it spontaneously regresses. It normally requires no treatment. We had the chance to operate on a 5-year-old boy with cherubism 8 years ago, and used homogenous bone grafts to replace the diseased tissue to avoid pathological fracture of the mandible. Since then we have been following the patient, witnessing the gradual involvement of other sites in the jaws and the displacement of teeth and tooth germs.

小天使病是一种良性的、遗传性的颌骨巨细胞病变,在儿童中表现为双侧无痛性肿胀,在2至5岁之间出现,直到青春期才会自发消退。它通常不需要治疗。8年前我们有机会给一个5岁的小男孩做了小天使畸形手术,用同种骨移植代替病变组织,避免了下颌骨的病理性骨折。从那时起,我们一直在跟踪病人,目睹了颌骨其他部位的逐渐累及以及牙齿和牙齿细菌的移位。
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引用次数: 1
Arthroscopy of the temporomandibular joint 颞下颌关节镜检查
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80089-2
Anders Holmlund , Gustaf Hellsing

Arthroscopy of the temporomandibular joint (TMJ) is evaluated on an autopsy material, 2 different types of arthroscope — one with a rod-lens system and one with a so-called Selfoc system — were used and compared regarding diagnostic accuracy. On 54 cadavers, it was found that the upper joint compartment may be punctured with accuracy and without damage to vital tissues. Landmarks on the skin facilitating clinical arthroscopy were defined in relation to a guideline from tragus to lateral canthus. A further 49 TMJ specimens were investigated with arthroscopy. The findings are in good agreement with subsequent observations made during dissection. Regarding arthrotic changes, 100% diagnostic accuracy was achieved with both types of arthroscope. Regarding remodelling changes, the diagnostic accuracy was approximately 57%. No significant difference was noticed between the 2 arthroscopes. Photographic documentation with the rod-lens arthroscope was found to be of superior quality.

在尸检材料上评估了颞下颌关节(TMJ)的关节镜,使用了两种不同类型的关节镜,一种是杆状透镜系统,一种是所谓的Selfoc系统,并对其诊断准确性进行了比较。在54具尸体上,发现可以准确地刺穿上部关节室,而不会损伤重要组织。根据从耳屏到外眦的指引,确定了便于临床关节镜检查的皮肤标志。另外49例TMJ标本经关节镜检查。这些发现与解剖过程中所做的观察结果很好地吻合。对于关节改变,两种类型的关节镜的诊断准确率均达到100%。关于重塑改变,诊断准确率约为57%。两种关节镜检查结果无明显差异。杆状透镜关节镜下的摄影文献质量较好。
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引用次数: 111
Ninth International Conference on Oral and Maxillofacial Surgery 第九届国际口腔颌面外科会议
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80094-6
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引用次数: 0
Meeting calendar 会议日程
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80098-3
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引用次数: 0
Psychological factors in temporomandibular joint dysfunction pain 心理因素对颞下颌关节功能障碍疼痛的影响
Pub Date : 1985-04-01 DOI: 10.1016/S0300-9785(85)80084-3
B. Speculand , A.N. Goss

Psychological factors are involved in TMJ dysfunction but much previous research has tried to identify single personality factors. Multiple factors, however, are involved. These can be divided into 2 main groups: external social factors and the innate psychiatric state of the patient. The concepts involved and their measurement by life events and illness behaviour questionnaires are discussed. The clinical importance of this to the oral surgeon is emphasised, in relation to the patient who fails to respond to conservative therapy and for whom TMJ surgery is planned. Some of these difficult patients may be less well socially integrated than the majority of TMJ patients.

心理因素与颞下颌关节功能障碍有关,但以往的许多研究都试图确定单一的人格因素。然而,这涉及到多种因素。这些因素可分为两大类:外部社会因素和患者的先天精神状态。所涉及的概念和他们的测量生活事件和疾病行为问卷进行了讨论。这对口腔外科医生的临床重要性被强调,涉及到对保守治疗无效的患者和计划进行TMJ手术的患者。与大多数颞下颌关节患者相比,这些困难患者中的一些可能没有很好地融入社会。
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引用次数: 39
期刊
International journal of oral surgery
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