首页 > 最新文献

International Journal of Radiation Biology最新文献

英文 中文
Recommendations for harmonized reporting of radiation Dosimetry by adoption of Compatibility in Irradiation Research Protocols Expert Roundtable (CIRPER) 通过辐照研究协议兼容性专家圆桌会议(CIRPER)统一辐射剂量测定报告的建议
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-04-03 DOI: 10.1080/09553002.2024.2331130
Warren Stern, Alaei Parham, Ross Berbeco, Larry A. DeWerd, Jacob Kamen, Carolyn MacKenzie, Eduardo G. Moros, Yannick Poirier, Charles A. Potter, Dörthe Schaue, Ileana Silvestre Patallo, Michael Abend, Steven Swarts, François Trompier
Published in International Journal of Radiation Biology (Ahead of Print, 2024)
发表于《国际辐射生物学杂志》(2024 年提前出版)
{"title":"Recommendations for harmonized reporting of radiation Dosimetry by adoption of Compatibility in Irradiation Research Protocols Expert Roundtable (CIRPER)","authors":"Warren Stern, Alaei Parham, Ross Berbeco, Larry A. DeWerd, Jacob Kamen, Carolyn MacKenzie, Eduardo G. Moros, Yannick Poirier, Charles A. Potter, Dörthe Schaue, Ileana Silvestre Patallo, Michael Abend, Steven Swarts, François Trompier","doi":"10.1080/09553002.2024.2331130","DOIUrl":"https://doi.org/10.1080/09553002.2024.2331130","url":null,"abstract":"Published in International Journal of Radiation Biology (Ahead of Print, 2024)","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"1 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction 预防辐射诱发恶心和呕吐(RINV)的膳食制剂:针对科学观察、益处、缺陷和未来方向的综述
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-03-20 DOI: 10.1080/09553002.2024.2309899
Princy Louis Palatty, Dhanya Sacheendran, Shamprasad Varija Raghu, Rajesh Arora, Suresh Rao, Manjeshwar Shrinath Baliga
Radiation-induced Nausea and Vomiting (RINV) is an important side effect and conservative estimates are that 50–80% of the patients undergoing curative radiotherapy (RT) will experience some sought...
放射治疗引起的恶心和呕吐(RINV)是一种重要的副作用,据保守估计,50%-80%的接受根治性放射治疗(RT)的患者都会出现某种程度的恶心和呕吐。
{"title":"Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction","authors":"Princy Louis Palatty, Dhanya Sacheendran, Shamprasad Varija Raghu, Rajesh Arora, Suresh Rao, Manjeshwar Shrinath Baliga","doi":"10.1080/09553002.2024.2309899","DOIUrl":"https://doi.org/10.1080/09553002.2024.2309899","url":null,"abstract":"Radiation-induced Nausea and Vomiting (RINV) is an important side effect and conservative estimates are that 50–80% of the patients undergoing curative radiotherapy (RT) will experience some sought...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"4 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140168385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-density polyethylene (HDPE)-incorporated boron carbide and boric acid nanoparticles as a nanoshield of photoneutrons from medical linear accelerators 高密度聚乙烯 (HDPE) 内含碳化硼和硼酸纳米粒子作为医用直线加速器光中子的纳米场
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-08 DOI: 10.1080/09553002.2023.2295964
Ali Vegari, Akbar Abdisaray, Kamal Mostafanejad, Nasrollah Jabbari
The current study aimed to investigate boron carbide and boric acid nanoparticles (NPs) as absorbents for thermal neutrons and high-density polyethylene (HDPE) as a substrate and neutron moderator ...
目前的研究旨在探讨碳化硼和硼酸纳米粒子(NPs)作为热中子吸收剂和高密度聚乙烯(HDPE)作为基底和中子慢化剂 ...
{"title":"High-density polyethylene (HDPE)-incorporated boron carbide and boric acid nanoparticles as a nanoshield of photoneutrons from medical linear accelerators","authors":"Ali Vegari, Akbar Abdisaray, Kamal Mostafanejad, Nasrollah Jabbari","doi":"10.1080/09553002.2023.2295964","DOIUrl":"https://doi.org/10.1080/09553002.2023.2295964","url":null,"abstract":"The current study aimed to investigate boron carbide and boric acid nanoparticles (NPs) as absorbents for thermal neutrons and high-density polyethylene (HDPE) as a substrate and neutron moderator ...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"126 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139397382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consideration of hereditary effects in the radiological protection system: evolution and current status 在放射防护系统中考虑遗传效应:演变和现状
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-08 DOI: 10.1080/09553002.2023.2295289
A. Amrenova, E. Ainsbury, C. Baudin, A. Giussani, J. Lochard, W. Rühm, P. Scholz-Kreisel, K. Trott, L. Vaillant, R. Wakeford, F. Zölzer, D. Laurier
The purpose of this paper is to provide an overview of the methodology used to estimate radiation genetic risks and quantify the risk of hereditary effects as outlined in the ICRP Publication 103. ...
本文旨在概述国际辐射防护委员会第 103 号出版物中用于估算辐射遗传风险和量化遗传效应风险的方法。...
{"title":"Consideration of hereditary effects in the radiological protection system: evolution and current status","authors":"A. Amrenova, E. Ainsbury, C. Baudin, A. Giussani, J. Lochard, W. Rühm, P. Scholz-Kreisel, K. Trott, L. Vaillant, R. Wakeford, F. Zölzer, D. Laurier","doi":"10.1080/09553002.2023.2295289","DOIUrl":"https://doi.org/10.1080/09553002.2023.2295289","url":null,"abstract":"The purpose of this paper is to provide an overview of the methodology used to estimate radiation genetic risks and quantify the risk of hereditary effects as outlined in the ICRP Publication 103. ...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"126 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139397442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation-induced multi-organ injury 辐射引起的多器官损伤
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-02 DOI: 10.1080/09553002.2023.2295298
Olivia Molinar-Inglis, Andrea L. DiCarlo, Paula J. Lapinskas, Carmen I. Rios, Merriline M. Satyamitra, Toby A. Silverman, Thomas A. Winters, David R. Cassatt
Natural history studies have been informative in dissecting radiation injury, isolating its effects, and compartmentalizing injury based on the extent of exposure and the elapsed time post-irradiat...
自然史研究在剖析辐射损伤、分离辐射影响以及根据辐照程度和辐照后的时间对损伤进行分区等方面提供了丰富的信息。
{"title":"Radiation-induced multi-organ injury","authors":"Olivia Molinar-Inglis, Andrea L. DiCarlo, Paula J. Lapinskas, Carmen I. Rios, Merriline M. Satyamitra, Toby A. Silverman, Thomas A. Winters, David R. Cassatt","doi":"10.1080/09553002.2023.2295298","DOIUrl":"https://doi.org/10.1080/09553002.2023.2295298","url":null,"abstract":"Natural history studies have been informative in dissecting radiation injury, isolating its effects, and compartmentalizing injury based on the extent of exposure and the elapsed time post-irradiat...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"34 2 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139077949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of sugarcane mutants developed through gamma irradiations for their lignin content and caffeic acid-O-methyl transferase (COMT) gene mutations 通过伽马辐照培育的甘蔗突变体木质素含量和咖啡酸-O-甲基转移酶(COMT)基因突变的特征分析
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-02 DOI: 10.1080/09553002.2023.2295962
Shaweta Sharma, Pawan Kumar Malhotra, Meenakshi Goyal, Vishal Sharma, Amandeep Mittal, Inderjit Singh Yadav, Gulzar Singh Sanghera, Parveen Chhuneja
Bagasse, the residue left after extracting juice from sugarcane stalks, is rich in lignocellulosic biomass. The lignin present in this plant biomass is the key factor that hinders the efficient ext...
甘蔗渣是从甘蔗茎秆中榨汁后留下的残渣,富含木质纤维素生物质。这种植物生物质中的木质素是阻碍蔗渣有效...
{"title":"Characterization of sugarcane mutants developed through gamma irradiations for their lignin content and caffeic acid-O-methyl transferase (COMT) gene mutations","authors":"Shaweta Sharma, Pawan Kumar Malhotra, Meenakshi Goyal, Vishal Sharma, Amandeep Mittal, Inderjit Singh Yadav, Gulzar Singh Sanghera, Parveen Chhuneja","doi":"10.1080/09553002.2023.2295962","DOIUrl":"https://doi.org/10.1080/09553002.2023.2295962","url":null,"abstract":"Bagasse, the residue left after extracting juice from sugarcane stalks, is rich in lignocellulosic biomass. The lignin present in this plant biomass is the key factor that hinders the efficient ext...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"29 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139077956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational model of radiation oxygen effect with Monte Carlo simulation: effects of antioxidants and peroxyl radicals 蒙特卡罗模拟辐射氧效应计算模型:抗氧化剂和过氧自由基的影响
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-02 DOI: 10.1080/09553002.2023.2295292
Ankang Hu, Wanyi Zhou, Rui Qiu, Shuoyang Wei, Zhen Wu, Hui Zhang, Junli Li
Oxygen plays a crucial role in radiation biology. Antioxidants and peroxyl radicals affect the oxygen effect greatly. This study aims to establish a computational model of the oxygen effect and exp...
氧在辐射生物学中起着至关重要的作用。抗氧化剂和过氧自由基对氧效应有很大影响。本研究旨在建立氧效应的计算模型,并探讨氧效应对辐射生物学的影响。
{"title":"Computational model of radiation oxygen effect with Monte Carlo simulation: effects of antioxidants and peroxyl radicals","authors":"Ankang Hu, Wanyi Zhou, Rui Qiu, Shuoyang Wei, Zhen Wu, Hui Zhang, Junli Li","doi":"10.1080/09553002.2023.2295292","DOIUrl":"https://doi.org/10.1080/09553002.2023.2295292","url":null,"abstract":"Oxygen plays a crucial role in radiation biology. Antioxidants and peroxyl radicals affect the oxygen effect greatly. This study aims to establish a computational model of the oxygen effect and exp...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139077997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraosseous distribution of 99mTc-diphosphonates during bone scintigraphy: review of the literature with case series presentation. 骨闪烁成像中 99mTc 二膦酸盐的骨外分布:文献综述与病例系列介绍。
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-01 Epub Date: 2023-08-10 DOI: 10.1080/09553002.2023.2242935
Miriam Conte, Maria Silvia De Feo, Viviana Frantellizzi, Francesco Marampon, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis

Purpose: Technetium-99m (99mTc)-diphosphonates represent the most common radiopharmaceutical used for bone scintigraphy. Even if the uptake in bone tissue has been widely explored, atypical uptake could be seen in soft tissue malignancies during bone scintigraphy. Increased vascularization and endothelium permeability represent front-row players in the biodistribution of the tracer, albeit other causes have been identified such as trauma, necrosis, the presence of calcification in metastasis, the pH of the tissue and consequently the type of ion concentration.

Conclusion: The aim of this paper is to summarize the state of art of atypical soft tissue uptake seen in cancer tissues. The research was conducted on PubMed. The analysis of the literature suggests that calcium metabolism and ionic saturation have a pivotal role in the biodistribution of bone tracers. This phenomenon ranks in a complex scenario that includes carcinogenesis and cancer environment aspects. We also report two cases in our Institution in which atypical uptake in cancer tissues was observed.

目的:锝-99m(99mTc)-二膦酸盐是骨闪烁成像最常用的放射性药物。尽管骨组织中的摄取已被广泛探究,但在骨闪烁成像过程中,软组织恶性肿瘤也会出现不典型的摄取。血管化和内皮通透性的增加是示踪剂生物分布的主要因素,但也发现了其他原因,如创伤、坏死、转移瘤中的钙化、组织的 pH 值以及离子浓度的类型:本文旨在总结癌症组织中非典型软组织摄取的最新进展。研究是在 PubMed 上进行的。文献分析表明,钙代谢和离子饱和度在骨示踪剂的生物分布中起着关键作用。这一现象涉及致癌和癌症环境等复杂因素。我们机构还报告了两例在癌症组织中观察到非典型吸收的病例。
{"title":"Extraosseous distribution of <sup>99m</sup>Tc-diphosphonates during bone scintigraphy: review of the literature with case series presentation.","authors":"Miriam Conte, Maria Silvia De Feo, Viviana Frantellizzi, Francesco Marampon, Luca Filippi, Orazio Schillaci, Giuseppe De Vincentis","doi":"10.1080/09553002.2023.2242935","DOIUrl":"10.1080/09553002.2023.2242935","url":null,"abstract":"<p><strong>Purpose: </strong>Technetium-99m (<b><sup>99m</sup></b>Tc)-diphosphonates represent the most common radiopharmaceutical used for bone scintigraphy. Even if the uptake in bone tissue has been widely explored, atypical uptake could be seen in soft tissue malignancies during bone scintigraphy. Increased vascularization and endothelium permeability represent front-row players in the biodistribution of the tracer, albeit other causes have been identified such as trauma, necrosis, the presence of calcification in metastasis, the pH of the tissue and consequently the type of ion concentration.</p><p><strong>Conclusion: </strong>The aim of this paper is to summarize the state of art of atypical soft tissue uptake seen in cancer tissues. The research was conducted on PubMed. The analysis of the literature suggests that calcium metabolism and ionic saturation have a pivotal role in the biodistribution of bone tracers. This phenomenon ranks in a complex scenario that includes carcinogenesis and cancer environment aspects. We also report two cases in our Institution in which atypical uptake in cancer tissues was observed.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":" ","pages":"18-27"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9964761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curative high-dose reirradiation for patients with recurrent head and neck adenoid cystic carcinomas: outcomes and analysis of patterns of failure. 对复发性头颈部腺样囊性癌患者进行根治性大剂量再照射:疗效和失败模式分析。
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-01 Epub Date: 2023-08-21 DOI: 10.1080/09553002.2023.2242934
Mathilde Mahé, Arnaud Beddok, Farid Goudjil, Catherine Ala Eddine, Stéphanie Bolle, Laurence Champion, Loïc Feuvret, Philippe Herman, Sofia Zefkili, Olivier Choussy, Christophe Le Tourneau, Remi Dendale, Irene Buvat, Elisabeth Sauvaget, Gilles Créhange, Valentin Calugaru

Background: To investigate the outcomes of patients who underwent curative reirradiation (reRT), with intensity-modulated radiation therapy (IMRT) or proton therapy (PT) for unresectable recurrent or second primary head and neck adenoid cystic carcinoma (HNACC).

Methods: Ten patients, mostly KPS 90%, were reirradiated (3/10 with IMRT and 7/10 with PT) at a median maximum dose to the CTV of 64.2 Gy from July 2011 to November 2021. Locations at the time of reRT were mainly the sinus (4/10) and the salivary glands (including the parotid and submandibular gland, 3/10). CTCAEv5 was used to assess acute and late toxicities. Follow-up was the time between the end of reRT and the date of last news.

Results: The median time between the two irradiations was 53.5 months (IQR: 18-84). After a median follow-up of 26 months (range, 12.5-51.8 months), six patients had developed a locoregional recurrence (LR), of which four occurred within the previously irradiated volume. Two and three-year locoregional failure-free survival (LFFS) and overall survival (OS) were 55.6% [95%CI: 31-99.7%], and 41% [18.5-94%] and 66.7% [42-100%] and 44.4% [21.4-92.3%], respectively. LFFS and OS were significantly better in the subgroup of sinus tumors (p = .013) and the subgroup of patients re-irradiated more than two years after the first course of irradiation (p = .01). Seven patients had impairments before the start of reRT, including hearing impairment (3/10) and facial nerve impairment (3/10). The most severe late toxicities were brain necrosis (2/10), osteoradionecrosis (1/10) and vision decreased (1/10).

Conclusion: Curative reRT for HNACC is possible for selected cases, but the LR rate in the irradiated field and the risk of severe toxicity remain high. Improved selection criteria and more carefully defined target volumes may improve outcome in these patients. A further study including larger cohort of patients would be useful to confirm these results.

研究背景目的:研究因无法切除的复发性或第二原发性头颈部腺样囊性癌(HNACC)而接受根治性再照射(reRT)、调强放射治疗(IMRT)或质子治疗(PT)的患者的疗效:2011年7月至2021年11月,10名患者接受了再放射治疗(3/10采用IMRT,7/10采用PT),CTV的中位最大剂量为64.2 Gy。再次照射的部位主要是鼻窦(4/10)和唾液腺(包括腮腺和颌下腺,3/10)。CTCAEv5用于评估急性和晚期毒性。随访时间为再照射结束至最后一次消息发布日期之间的时间:两次照射之间的中位时间为 53.5 个月(IQR:18-84)。中位随访26个月(12.5-51.8个月)后,6名患者出现了局部复发(LR),其中4例发生在之前接受过照射的区域。两年和三年的无局部失败生存率(LFFS)和总生存率(OS)分别为55.6% [95%CI:31-99.7%]和41% [18.5-94%],以及66.7% [42-100%]和44.4% [21.4-92.3%]。窦状肿瘤亚组(p = .013)和首次照射后两年以上再次照射的患者亚组(p = .01)的LFFS和OS明显更好。有七名患者在开始再照射前就出现了功能障碍,包括听力障碍(3/10)和面神经障碍(3/10)。最严重的晚期毒性反应是脑坏死(2/10)、骨坏死(1/10)和视力下降(1/10):结论:HNACC 的治愈性再放射治疗可用于部分病例,但照射野的 LR 率和严重毒性的风险仍然很高。改进选择标准和更仔细地界定靶区可能会改善这些患者的预后。包括更多患者在内的进一步研究将有助于证实这些结果。
{"title":"Curative high-dose reirradiation for patients with recurrent head and neck adenoid cystic carcinomas: outcomes and analysis of patterns of failure.","authors":"Mathilde Mahé, Arnaud Beddok, Farid Goudjil, Catherine Ala Eddine, Stéphanie Bolle, Laurence Champion, Loïc Feuvret, Philippe Herman, Sofia Zefkili, Olivier Choussy, Christophe Le Tourneau, Remi Dendale, Irene Buvat, Elisabeth Sauvaget, Gilles Créhange, Valentin Calugaru","doi":"10.1080/09553002.2023.2242934","DOIUrl":"10.1080/09553002.2023.2242934","url":null,"abstract":"<p><strong>Background: </strong>To investigate the outcomes of patients who underwent curative reirradiation (reRT), with intensity-modulated radiation therapy (IMRT) or proton therapy (PT) for unresectable recurrent or second primary head and neck adenoid cystic carcinoma (HNACC).</p><p><strong>Methods: </strong>Ten patients, mostly KPS 90%, were reirradiated (3/10 with IMRT and 7/10 with PT) at a median maximum dose to the CTV of 64.2 Gy from July 2011 to November 2021. Locations at the time of reRT were mainly the sinus (4/10) and the salivary glands (including the parotid and submandibular gland, 3/10). CTCAEv5 was used to assess acute and late toxicities. Follow-up was the time between the end of reRT and the date of last news.</p><p><strong>Results: </strong>The median time between the two irradiations was 53.5 months (IQR: 18-84). After a median follow-up of 26 months (range, 12.5-51.8 months), six patients had developed a locoregional recurrence (LR), of which four occurred within the previously irradiated volume. Two and three-year locoregional failure-free survival (LFFS) and overall survival (OS) were 55.6% [95%CI: 31-99.7%], and 41% [18.5-94%] and 66.7% [42-100%] and 44.4% [21.4-92.3%], respectively. LFFS and OS were significantly better in the subgroup of sinus tumors (<i>p = .013</i>) and the subgroup of patients re-irradiated more than two years after the first course of irradiation (<i>p = .01</i>). Seven patients had impairments before the start of reRT, including hearing impairment (3/10) and facial nerve impairment (3/10). The most severe late toxicities were brain necrosis (2/10), osteoradionecrosis (1/10) and vision decreased (1/10).</p><p><strong>Conclusion: </strong>Curative reRT for HNACC is possible for selected cases, but the LR rate in the irradiated field and the risk of severe toxicity remain high. Improved selection criteria and more carefully defined target volumes may improve outcome in these patients. A further study including larger cohort of patients would be useful to confirm these results.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":" ","pages":"79-86"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10035604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
In vitro induction and selection of mutants obtained through gamma irradiation with improved processing traits in potato (Solanum tuberosum L.). 体外诱导和筛选通过伽马辐照获得的突变体,改善马铃薯(Solanum tuberosum L.)的加工性状。
IF 2.6 4区 医学 Q2 BIOLOGY Pub Date : 2024-01-01 Epub Date: 2023-08-14 DOI: 10.1080/09553002.2023.2245472
Rupinder Kaur, Sat Pal Sharma, Anu Kalia, Navraj Kaur, Pooja Manchanda

Purpose: This manuscript aimed for the generation of γ-irradiation derived mutants of potato genotype PAU/RR-1501 possessing desirable processing traits.

Materials and methods: Nodal cuttings from virus-free explants were established on basal MS medium and irradiated with different doses (0, 5, 10 and 20 Gy) of γ-irradiation. The 5 and 10 Gy treated plantlets were multiplied and used for micro-tuber induction. Harvested micro-tubers were planted in pots for the selection and evaluation of mutants in M1V2 generation.

Results: Four weeks post-treatment, plantlets (5 Gy) showed enhanced growth as compared to the control while 20 Gy treatment exhibited completely ceased shoot growth. The highest number and weight of mini-tubers per plant was recorded for 10 Gy followed by 5 Gy treatment as compared to control. The γ-irradiation treatments caused changes in the skin color and shape of M1V2 tubers.

Conclusion: Under the 5 Gy treatment 49.9% of clones produced exhibited cream and 8.53% brown skin color. Nine putative mutants were identified in genotype PAU/RR-1501 exhibiting promising processing traits.

目的:本手稿旨在生成具有理想加工性状的马铃薯基因型 PAU/RR-1501 的γ-辐照衍生突变体:在基础 MS 培养基上建立无病毒外植体的节间插条,并用不同剂量(0、5、10 和 20 Gy)的 γ 辐射照射。经 5 和 10 Gy 处理的小植株被繁殖并用于微管诱导。收获的微管种植在花盆中,用于 M1V2 代突变体的筛选和评估:处理后四周,与对照组相比,5 Gy 处理的小苗生长速度加快,而 20 Gy 处理的小苗则完全停止了生长。与对照相比,10 Gy 处理的每株小管数量和重量最高,其次是 5 Gy 处理。γ-辐照处理导致 M1V2 块茎的表皮颜色和形状发生变化:结论:在 5 Gy 处理下,49.9% 的克隆表现出奶油色,8.53% 的克隆表现出棕色。在基因型 PAU/RR-1501 中发现了 9 个推定突变体,这些突变体具有良好的加工性状。
{"title":"<i>In vitro</i> induction and selection of mutants obtained through gamma irradiation with improved processing traits in potato (<i>Solanum tuberosum</i> L.).","authors":"Rupinder Kaur, Sat Pal Sharma, Anu Kalia, Navraj Kaur, Pooja Manchanda","doi":"10.1080/09553002.2023.2245472","DOIUrl":"10.1080/09553002.2023.2245472","url":null,"abstract":"<p><strong>Purpose: </strong>This manuscript aimed for the generation of γ-irradiation derived mutants of potato genotype PAU/RR-1501 possessing desirable processing traits.</p><p><strong>Materials and methods: </strong>Nodal cuttings from virus-free explants were established on basal MS medium and irradiated with different doses (0, 5, 10 and 20 Gy) of γ-irradiation. The 5 and 10 Gy treated plantlets were multiplied and used for micro-tuber induction. Harvested micro-tubers were planted in pots for the selection and evaluation of mutants in M1V2 generation.</p><p><strong>Results: </strong>Four weeks post-treatment, plantlets (5 Gy) showed enhanced growth as compared to the control while 20 Gy treatment exhibited completely ceased shoot growth. The highest number and weight of mini-tubers per plant was recorded for 10 Gy followed by 5 Gy treatment as compared to control. The γ-irradiation treatments caused changes in the skin color and shape of M1V2 tubers.</p><p><strong>Conclusion: </strong>Under the 5 Gy treatment 49.9% of clones produced exhibited cream and 8.53% brown skin color. Nine putative mutants were identified in genotype PAU/RR-1501 exhibiting promising processing traits.</p>","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":" ","pages":"139-149"},"PeriodicalIF":2.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10050650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Radiation Biology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1