Pub Date : 2023-10-06DOI: 10.26452/ijrps.v14i4.4448
Noor Mohamed M, Parameswari M, Pavithra B, Naveen Kumar S, Nirmal Kumar P, Jothirani P
Raphinus sativus extract was prepared by Soxhlet extraction method using various solvents such as ethyl acetate (polar solvent) water and ethanol (nonpolar). The chemical test was performed to identify the presence of flavonoid content. Among them ethyl acetate extract shows a high flavonoid content.So it was used for further studies. By using the in vitro agar well diffusion method, antibacterial activity was measured in all extracts. 2 strains of bacteria were chosen for testing, including gram-positive (Staphylococcus aureus, ATCC25923) and gram-negative (E. coli, ATCC25922) bacteria. The diameter of the zone of inhibition were measured and compared to the amoxicillin reference standard.Compared to gram-positive bacteria, the extract exhibits higher potential activity against gram-negative bacteria. Concentration directly relates to how much action is taken.
{"title":"The Antibacterial Activity of Various Solvent Extracts of Leaves of Raphunus sativus","authors":"Noor Mohamed M, Parameswari M, Pavithra B, Naveen Kumar S, Nirmal Kumar P, Jothirani P","doi":"10.26452/ijrps.v14i4.4448","DOIUrl":"https://doi.org/10.26452/ijrps.v14i4.4448","url":null,"abstract":"Raphinus sativus extract was prepared by Soxhlet extraction method using various solvents such as ethyl acetate (polar solvent) water and ethanol (nonpolar). The chemical test was performed to identify the presence of flavonoid content. Among them ethyl acetate extract shows a high flavonoid content.So it was used for further studies. By using the in vitro agar well diffusion method, antibacterial activity was measured in all extracts. 2 strains of bacteria were chosen for testing, including gram-positive (Staphylococcus aureus, ATCC25923) and gram-negative (E. coli, ATCC25922) bacteria. The diameter of the zone of inhibition were measured and compared to the amoxicillin reference standard.Compared to gram-positive bacteria, the extract exhibits higher potential activity against gram-negative bacteria. Concentration directly relates to how much action is taken.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135350937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-19DOI: 10.26452/ijrps.v14i3.4310
M. C., Hasna P, Nayana Km, Jassim M, Aparna Ks
Stroke comprises of a broad term encompassing many disorders of the blood vessels of the central nervous system that may result from either inadequate blood flow to the brain with subsequent infarction of the involved portion of the CNS or haemorrhages into the parenchyma or subarachnoid space of the CNS causing neurologic dysfunction. Stroke is one of the major cause of mortality worldwide. The objective of the study was to assess the drug utilization pattern (DUP) and to evaluate the impact of counseling on medication adherence for stroke patient admitted in the hospital. Dual antiplatelet therapy (69.4%) was mostly given over monotherapy (28.2%). CCB (28.2%) was the most commonly prescribed antihypertensive drug class and amlodipine (77.1%) was the major CCB given in this study. 96.5 prescriptions comply AHA/ASA guidelines. Unintentional reasons for nonadherence were been reported more frequently than intentional reasons prior to the counseling. The commonest reported unintentional reasons were Forgetfulness (96.0%), Confusion (80.0%) and intentional reasons are carelessness (92%), avoiding dosing schedule (78%). Medication adherence before and after counseling was compared and was found to be improved with a statistically significant (p
{"title":"Drug Utilization Pattern and Role of Clinical Pharmacist in Medication Adherence of Stroke Patients in a Tertiary Care Hospital, South India: A Prospective Observational Study","authors":"M. C., Hasna P, Nayana Km, Jassim M, Aparna Ks","doi":"10.26452/ijrps.v14i3.4310","DOIUrl":"https://doi.org/10.26452/ijrps.v14i3.4310","url":null,"abstract":"Stroke comprises of a broad term encompassing many disorders of the blood vessels of the central nervous system that may result from either inadequate blood flow to the brain with subsequent infarction of the involved portion of the CNS or haemorrhages into the parenchyma or subarachnoid space of the CNS causing neurologic dysfunction. Stroke is one of the major cause of mortality worldwide. The objective of the study was to assess the drug utilization pattern (DUP) and to evaluate the impact of counseling on medication adherence for stroke patient admitted in the hospital. Dual antiplatelet therapy (69.4%) was mostly given over monotherapy (28.2%). CCB (28.2%) was the most commonly prescribed antihypertensive drug class and amlodipine (77.1%) was the major CCB given in this study. 96.5 prescriptions comply AHA/ASA guidelines. Unintentional reasons for nonadherence were been reported more frequently than intentional reasons prior to the counseling. The commonest reported unintentional reasons were Forgetfulness (96.0%), Confusion (80.0%) and intentional reasons are carelessness (92%), avoiding dosing schedule (78%). Medication adherence before and after counseling was compared and was found to be improved with a statistically significant (p","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79302939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-16DOI: 10.26452/ijrps.v14i3.4308
Hemamalini K, Sadanandam Palle, Kanakam Vijayabhaskar, Supraja U
Liver injury is a common disorder where natural remedies are practiced from ancient time from plant source which shows alternative treatment in a safe manner. The Hepatoprotective activity of methanolic extract of Prosopis juiliflora bark part was taken for evaluation in screening. The model chosen for the study is carbon tetrachloride (0.1ml/kg) and the standard drug silymarin of 20mg/kg was used for the study for 21 days. The hepatoprotective effect of the methanolic extract against the carbon tetrachloride-induced hepatotoxicity in wistar rats has been demonstrated by the substantial and severe reduction of enzymes in the serum.
{"title":"Phytochemical and Hepatoprotective Activity of Prosopis juliflora Barks on Different Models","authors":"Hemamalini K, Sadanandam Palle, Kanakam Vijayabhaskar, Supraja U","doi":"10.26452/ijrps.v14i3.4308","DOIUrl":"https://doi.org/10.26452/ijrps.v14i3.4308","url":null,"abstract":"Liver injury is a common disorder where natural remedies are practiced from ancient time from plant source which shows alternative treatment in a safe manner. The Hepatoprotective activity of methanolic extract of Prosopis juiliflora bark part was taken for evaluation in screening. The model chosen for the study is carbon tetrachloride (0.1ml/kg) and the standard drug silymarin of 20mg/kg was used for the study for 21 days. The hepatoprotective effect of the methanolic extract against the carbon tetrachloride-induced hepatotoxicity in wistar rats has been demonstrated by the substantial and severe reduction of enzymes in the serum.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84886566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-11DOI: 10.26452/ijrps.v14i3.4306
Akighir J, Yakubu O E, Imo C, Ojogbane E, Owuna R I, Jato J A
In order to assess the total antioxidant capacity (TAC), total polyphenol content (TPC), and total flavonoid content (TFC) in ethanol fruit extract, as well as to ascertain the relationship between the antioxidant effects and phytochemical levels, this study looked at all three variables. 11 groups of 10 rats each were formed out of the experimental animals. All experimental subjects received a single intraperitoneal injection of aluminium chloride, 4.2 mg/kg body weight. Groups 4 and 5 received n-hexane fraction at 10 and 20 mg/kg b. w., respectively, whereas the other groups received various fractions and crude extracts of R. hookeri. Ethyl acetate fraction was given to groups 6 and 7 at doses of 10 and 20 mg/kg b. w. Aqueous fractions at 10 and 20 mg/kg b. w. were given to groups 8 and 9. While groups 10 and 11 got ethanolic crude extract daily for 21 days at doses of 200 mg/kg b. w. and 400 mg/kg b. w., respectively. All groups that were given AlCl3 - induced TBARS showed a significant (P 0.05) increase in vivo antioxidant activity. However, in the liver, kidney, and testes of all treatment groups, superoxide dismutase (SOD) and catalase (CAT) activity considerably increased (P 0.05). This suggests that a significant portion of the antioxidant activity displayed by the ethanolic fruit extract of R. hookeri is due to flavonoids.
为了评估乙醇水果提取物的总抗氧化能力(TAC)、总多酚含量(TPC)和总黄酮含量(TFC)，并确定抗氧化作用与植物化学水平之间的关系，本研究考察了这三个变量。实验动物共分成11组，每组10只大鼠。所有受试者均一次性腹腔注射氯化铝，剂量为4.2 mg/kg体重。第4组和第5组分别给予10和20 mg/kg体重的正己烷部位，其余组分别给予黄颡鱼不同部位和粗提物。第6组和第7组分别以10和20 mg/kg体重给予乙酸乙酯馏分，第8组和第9组分别以10和20 mg/kg体重给予水馏分。第10组和第11组分别以200 mg/kg b. w和400 mg/kg b. w的剂量给予乙醇粗提物，连续21 d。所有给予AlCl3诱导的TBARS组的体内抗氧化活性均显著提高(p0.05)。各处理组肝脏、肾脏和睾丸超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性均显著升高(P < 0.05)。由此可见，黄酮类化合物是水仙果醇提取物抗氧化活性的重要组成部分。
{"title":"Evaluation of the total antioxidant capacity, total polyphenol content, and flavonoids content in ethanolic fruit extract of Raphia hookeri and determination of the correlation between the antioxidant effects and the phytochemical contents","authors":"Akighir J, Yakubu O E, Imo C, Ojogbane E, Owuna R I, Jato J A","doi":"10.26452/ijrps.v14i3.4306","DOIUrl":"https://doi.org/10.26452/ijrps.v14i3.4306","url":null,"abstract":"In order to assess the total antioxidant capacity (TAC), total polyphenol content (TPC), and total flavonoid content (TFC) in ethanol fruit extract, as well as to ascertain the relationship between the antioxidant effects and phytochemical levels, this study looked at all three variables. 11 groups of 10 rats each were formed out of the experimental animals. All experimental subjects received a single intraperitoneal injection of aluminium chloride, 4.2 mg/kg body weight. Groups 4 and 5 received n-hexane fraction at 10 and 20 mg/kg b. w., respectively, whereas the other groups received various fractions and crude extracts of R. hookeri. Ethyl acetate fraction was given to groups 6 and 7 at doses of 10 and 20 mg/kg b. w. Aqueous fractions at 10 and 20 mg/kg b. w. were given to groups 8 and 9. While groups 10 and 11 got ethanolic crude extract daily for 21 days at doses of 200 mg/kg b. w. and 400 mg/kg b. w., respectively. All groups that were given AlCl3 - induced TBARS showed a significant (P 0.05) increase in vivo antioxidant activity. However, in the liver, kidney, and testes of all treatment groups, superoxide dismutase (SOD) and catalase (CAT) activity considerably increased (P 0.05). This suggests that a significant portion of the antioxidant activity displayed by the ethanolic fruit extract of R. hookeri is due to flavonoids.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89709304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-09DOI: 10.26452/ijrps.v14i3.4302
Nupur Shukla, Monika Gupta
In the present era, with the evolution in the medical field, many parameters have gained importance in researches by the forensic experts, anthropologists in the identification of biological remains. Nowadays, complete human skeletons can be used for the identification of the biological profile of an individual. One of the emerging parameters are the foot dimensions in identification and gender determination. The study was conducted on 207 males & 200 females from Rajasthan adult population of age group 17 to 25 years. The anthropometric measurements of left foot length and breadth were measured by the digital sliding caliper. Significant Foot index was calculated, it was found that the overall left foot index for males was 37.89 and females was 38.24. This indicates that the value of left foot index is less than 38 in male but more than 38 in females. This 38 value obtained can be the deviation point in predicting the gender, by calculating the left foot index.
{"title":"Gender Determination by Using Left Foot Index in Rajasthan Adults","authors":"Nupur Shukla, Monika Gupta","doi":"10.26452/ijrps.v14i3.4302","DOIUrl":"https://doi.org/10.26452/ijrps.v14i3.4302","url":null,"abstract":"In the present era, with the evolution in the medical field, many parameters have gained importance in researches by the forensic experts, anthropologists in the identification of biological remains. Nowadays, complete human skeletons can be used for the identification of the biological profile of an individual. One of the emerging parameters are the foot dimensions in identification and gender determination. The study was conducted on 207 males & 200 females from Rajasthan adult population of age group 17 to 25 years. The anthropometric measurements of left foot length and breadth were measured by the digital sliding caliper. Significant Foot index was calculated, it was found that the overall left foot index for males was 37.89 and females was 38.24. This indicates that the value of left foot index is less than 38 in male but more than 38 in females. This 38 value obtained can be the deviation point in predicting the gender, by calculating the left foot index.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78624392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.26452/ijrps.v14i2.4286
Anandh A
check
检查
{"title":"Test","authors":"Anandh A","doi":"10.26452/ijrps.v14i2.4286","DOIUrl":"https://doi.org/10.26452/ijrps.v14i2.4286","url":null,"abstract":"check","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136155697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.26452/ijrps.v14i2.4278
Anandh A
check.
检查。
{"title":"Test","authors":"Anandh A","doi":"10.26452/ijrps.v14i2.4278","DOIUrl":"https://doi.org/10.26452/ijrps.v14i2.4278","url":null,"abstract":"check.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135046405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.26452/ijrps.v14i2.4274
Anandh A
check.
检查。
{"title":"Test","authors":"Anandh A","doi":"10.26452/ijrps.v14i2.4274","DOIUrl":"https://doi.org/10.26452/ijrps.v14i2.4274","url":null,"abstract":"check.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136355463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.26452/ijrps.v14i2.4283
Anandh A
check
检查
{"title":"Test","authors":"Anandh A","doi":"10.26452/ijrps.v14i2.4283","DOIUrl":"https://doi.org/10.26452/ijrps.v14i2.4283","url":null,"abstract":"check","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135046416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-17DOI: 10.26452/ijrps.v14i2.4276
Anandh A
Checking.
检查。
{"title":"Test","authors":"Anandh A","doi":"10.26452/ijrps.v14i2.4276","DOIUrl":"https://doi.org/10.26452/ijrps.v14i2.4276","url":null,"abstract":"Checking.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135916726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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