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Relation between vitamins of the b complex, GABA and glutamate, and their role in neurocognitive disorders -Brief review 维生素b复合物、GABA和谷氨酸的关系及其在神经认知障碍中的作用——综述
Pub Date : 2016-11-29 DOI: 10.14419/IJBAS.V5I4.6707
R. Justo, M. César, E. Migowski, R. Cisne
Vitamins, especially the water-soluble complex of vitamins B, are highlighted in the daily clinical practice. Numerous studies emphasize the need for supplementation, mainly in groups with deficiency of these vitamins, such as the elderly, pregnant women, children and patients with diseases associates with cognitive disorder. Thiamine (B1), a vitamin of the diet, is an important cofactor for the three key enzymes involved in the citric acid cycle and the pentose phosphate cycle. Pyridoxine (B6) and cobalamin (B12) act in the CNS as a cofactor in the metabolism reactions of homocysteine. Deficiency of some neurotransmitter precursors can also cause symptoms of attention deficit hyperactivity disorder in children, especially amino acid and vitamin B deficiency. Inhibitory and excitatory neurotransmitters regulate diverse behavioral processes, including sleep, learning, memory and sensation of pain. They are also implicated in many pathological processes, such as epilepsy and neurotoxicity. Studies suggest that the excitatory amino acids may play a role in learning and memory. The binding of glutamate to its receptor triggers molecular and cellular events associated with numerous physiological and pathophysiological pathways, including the development of an increased sensation of pain (hyperalgesia), brain neurotoxicity or synaptic alterations involved in certain types of memory formation. Between the two major classes of neuroactive amino acids, γ-aminobutyric acid (GABA) is the major inhibitory amino acid. It is known that GABA plays a fundamental role in encoding information and behavioral control, in the regulation of motor function and in motor learning. The inter-relationships between diet, the brain and behavior are complex. However, micronutrients are known to have a direct influence on cognitive function through their involvement in the energy metabolism of neurons and glia cells, the synthesis of neurotransmitters, receptor binding and the maintenance of membrane ion pumps.
维生素,特别是维生素B的水溶性复合物,在日常临床实践中被强调。许多研究强调需要补充维生素,主要针对缺乏这些维生素的群体,如老年人、孕妇、儿童和患有与认知障碍有关疾病的患者。硫胺素(B1)是饮食中的一种维生素,是参与柠檬酸循环和戊糖磷酸循环的三种关键酶的重要辅助因子。吡哆醇(B6)和钴胺素(B12)在中枢神经系统中作为同型半胱氨酸代谢反应的辅助因子。某些神经递质前体缺乏也可引起儿童注意缺陷多动障碍的症状,特别是氨基酸和维生素B缺乏。抑制性和兴奋性神经递质调节多种行为过程,包括睡眠、学习、记忆和疼痛感觉。它们还涉及许多病理过程,如癫痫和神经毒性。研究表明,兴奋性氨基酸可能在学习和记忆中发挥作用。谷氨酸与其受体的结合引发了与许多生理和病理生理途径相关的分子和细胞事件,包括疼痛感的增加(痛觉过敏)、脑神经毒性或与某些类型的记忆形成有关的突触改变。在两大类神经活性氨基酸中,γ-氨基丁酸(GABA)是主要的抑制氨基酸。GABA在信息编码、行为控制、运动功能调节、运动学习等方面发挥着重要作用。饮食、大脑和行为之间的相互关系是复杂的。然而,已知微量营养素通过参与神经元和神经胶质细胞的能量代谢、神经递质的合成、受体结合和膜离子泵的维持,对认知功能有直接影响。
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引用次数: 3
The use of drugs for the treatment of xerostomia – brief review 治疗口干症的药物应用综述
Pub Date : 2016-11-29 DOI: 10.14419/IJBAS.V5I4.6708
M. César, R. Justo, J. Vidal, Maurício Bonel, E. Migowski, R. Cisne
Inadequate production of saliva causes an oral imbalance that has a great impact on the individual's quality of life. Diseases of various types are responsible for impaired production of saliva and dry mouth, as happens in xerostomia. It is usually associated with hypofunction of the salivary glands, which shows signs of dryness on oral mucosa, and other morphological features in the oral cavity. Saliva is composed of water and 1% of electrolytes and immunoglobulins, enzymes and other proteins. Its fluid component, which contains ions, is mainly produced by parasympathetic stimulation, while the protein component, produced in the acinar secretory vesicles, is released by sympathetic stimulation. The use of certain drugs is a major cause of xerostomia. Among these we found analgesics, anticonvulsants, antihistamines, antihypertensives, diuretics and antidepressants. The treatment is mainly done by saliva substitutes such as sodium chloride, potassium chloride, monopotassium phosphate and dipotassium phosphate. However, in some cases, stimulants, such as citric acid and sodium citrate, or even topical salivary substitutes can be effective. Furthermore, the use of specific oral care products is well accepted by the patients. The treatment is selected according to the ability of the glands to produce saliva. It is still not fully known what mechanism of action drugs that cause hyposalivation, dry mouth or changes in saliva composition use. Yet, it is important to know the side effects of prescribed drugs.
唾液分泌不足会导致口腔失衡,严重影响个人的生活质量。各种类型的疾病都是导致唾液分泌受损和口干的原因,就像口干症一样。它通常与唾液腺功能减退有关,表现为口腔黏膜干燥和其他口腔形态学特征。唾液由水和1%的电解质、免疫球蛋白、酶和其他蛋白质组成。其含有离子的液体成分主要由副交感神经刺激产生,而在腺泡分泌囊中产生的蛋白质成分则由交感神经刺激释放。某些药物的使用是导致口干症的主要原因。在这些药物中,我们发现了镇痛药、抗惊厥药、抗组胺药、抗高血压药、利尿剂和抗抑郁药。治疗方法主要是用氯化钠、氯化钾、磷酸一钾和磷酸二钾等唾液代用品。然而,在某些情况下,兴奋剂,如柠檬酸和柠檬酸钠,甚至局部唾液替代品都是有效的。此外,患者对特定口腔护理产品的使用也很接受。根据腺体分泌唾液的能力选择治疗方法。目前尚不完全清楚药物引起唾液分泌不足、口干或唾液成分改变的作用机制。然而,了解处方药的副作用是很重要的。
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引用次数: 1
Application of HACCP in an Indonesian halal restaurant by incorporating halal dietary requirements HACCP在印尼清真餐厅的应用,纳入清真饮食要求
Pub Date : 2016-11-28 DOI: 10.14419/IJBAS.V5I4.6469
B. Jiang, H. P. Putra
This study investigates the safety of ayam lalapan food processing in the catering service, and considers Halal dietary requirements due to the increasing demand for Halal food. Hazard and Haram Analysis Critical Control Point (HHACCP) proposed by Kohilavani et al. [1] is used to analyze the potential hazards as well as to improve the safety of food processing. By using this method, the presence of haram substance is analyzed aside from the regular hazard analysis, which consists of biological, chemical and physical hazards. Critical control points and Halal critical control points are identified to guarantee that the food processing of ayam lalapan meets Halal dietary requirements and is safe for human consumption. The total risk level after improvement can be reduced by 75.64% from 1.05 to 0.29 compared to before improvement.
本研究调查了在餐饮服务中加工ayam alapan食品的安全性,并考虑了清真食品需求的增加对清真饮食的要求。Kohilavani等[1]提出了危害与危害分析关键控制点(HHACCP),用于分析潜在危害,提高食品加工的安全性。通过使用这种方法,除了常规的危害分析之外,还分析了有害物质的存在,危害分析包括生物,化学和物理危害。确定了关键控制点和清真关键控制点,以保证ayam lalapan的食品加工符合清真饮食要求,并安全供人类食用。改进后的总风险等级从1.05降至0.29,比改进前降低了75.64%。
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引用次数: 0
Compliance to standard precautions among nurses working in Qassim hospitals in KSA 在沙特阿拉伯卡西姆医院工作的护士遵守标准预防措施的情况
Pub Date : 2016-11-23 DOI: 10.14419/IJBAS.V5I4.6832
F. Mersal, L. I. Keshk
Background: Compliance with standard precautions has been shown to reduce the risk of exposure to blood and body fluids. Nurses represent the largest percentage of the health care workers hence; their compliance with standard precautions guidelines seems to be more crucial in preventing the disease transmission among patients. Aim: this study aims to evaluate compliance to standard precautions among nurses working in Qassim Hospitals in KSA. Methodology: A cross sectional study was conducted in 4 multispecialty hospitals of Al-Qassim region, KSA. A purposive sampling approach was adopted whereas sample consisted of 284 male and female nurses working in multispecialty hospitals. Data collected through self-administrative questionnaire which consists of; personal and work characteristics of nurses, nurses’ knowledge and compliance of standard precautions. Results: Nearly half of nurses had poor knowledge regarding standard precautions and the majority of nurses had better compliance to standard precautions. However nearly one third of nurses had good compliance to waste disposal. Conclusions: Compulsive training courses found to be vital for developing awareness among nurses, improving compliance to standard precautions and good clinical practice. Recommendations: Further studies are recommended by using different methods for data collection. Written universal precautions guidelines for infection control should be available.
背景:已证明遵守标准预防措施可减少接触血液和体液的风险。因此,护士在卫生保健工作者中所占比例最大;他们对标准预防指南的遵守似乎对预防患者之间的疾病传播更为重要。目的:本研究旨在评估在沙特阿拉伯卡西姆医院工作的护士对标准预防措施的依从性。方法:在沙特阿拉伯Al-Qassim地区的4家多专科医院进行了横断面研究。采用有目的的抽样方法,样本由284名在多专科医院工作的男女护士组成。通过自我管理问卷收集的数据包括:护士的个人和工作特点,护士的知识和遵守标准的预防措施。结果:近一半的护士对标准预防措施的了解程度较低,大部分护士对标准预防措施的依从性较好。然而,近三分之一的护士对废物处理有良好的依从性。结论:强迫性培训课程对提高护士意识,提高对标准预防措施的依从性和良好的临床实践至关重要。建议:建议采用不同的数据收集方法进行进一步的研究。应提供书面的感染控制通用预防指南。
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引用次数: 4
Effects of an educational program in increasing knowledge and reducing premenstrual syndrome signs, symptoms and severity among nursing college students 一项教育计划在护理学院学生中增加知识和减少经前症候群征兆、症状和严重程度的效果
Pub Date : 2016-10-28 DOI: 10.14419/IJBAS.V5I4.6001
Nafisa Abdalla, Mohammed Gibreel
Objective: The objective of the following study is to determine the effects of an Educational Program in increasing knowledge and reducing premenstrual syndrome symptoms and severity among nursing college students. Material and Methods: A total of 60 students with Premenstrual Syndrome (PMS) symptoms were included in the study group (n=60), the age of the majority of them (75.8%) was between 20-24 years, pre and post education program questionnaire was developed as a tool of data collection before and after the educational program. Also premenstrual symptoms and severity follow-up sheet was designed and conducted three month after the post education program to follow the effectiveness of the educational program in reducing the severity of the symptoms. Results: The study results indicate that there was significant difference between students’ knowledge before and after the program, the total score mean rank before program was (34.72), while after program was (86.28) p < 0.01 with significant difference between score before and after the program at 1% level of significant. It also shows a significant difference between PMS signs, symptoms and severity before and after program at 1% level of significant (total score mean and SD before program were (132.42, 13.72) respectively, and after program are (107.52, 14.47) respectively p < 0.01 with larger effect size of 0.613. The follow-up result shows a reduction in PMS symptom’s severity, the total severity averages of PMS sign and symptoms were 3.4 first month, 2.6 the second month and 2.2 for the third month out of 4 respectively. Conclusion: The educational program had a positive effect on increasing knowledge and decreasing PMS signs and symptoms severity. Also the program has decrease the effect of PMS signs and symptoms on study group life.
目的:以下研究的目的是确定教育计划在增加知识和减少经前综合征症状和严重程度的护理学院学生的效果。材料与方法:研究组共60例经前综合征(PMS)学生(n=60),年龄以20 ~ 24岁为主(75.8%),制定教育计划前后问卷作为教育计划前后资料收集工具。此外,经前症状和严重程度随访表被设计并在教育后三个月进行,以跟踪教育计划在减轻症状严重程度方面的有效性。结果:研究结果表明,学生在项目前后的知识水平存在显著性差异,项目前总分平均排名为(34.72),项目后总分平均排名为(86.28),p < 0.01,在1%的显著水平上,项目前后得分差异显著。治疗前后PMS体征、症状和严重程度在1%的显著水平上也有显著差异(治疗前总分均值和标准差分别为(132.42,13.72),治疗后总分均值和标准差分别为(107.52,14.47)p < 0.01,效应量为0.613。随访结果显示经前症候群症状的严重程度有所减轻,经前症候群症状和体征的总严重程度平均第一个月为3.4,第二个月为2.6,第三个月为2.2。结论:教育方案对提高经前症候群知识和降低经前症候群症状和体征的严重程度有积极作用。此外,该计划还减少了经前综合症的症状和体征对研究小组生活的影响。
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引用次数: 7
Photo-acoustic properties of nanoTiO2:Er 纳米tio2:Er的光声性质
Pub Date : 2016-10-10 DOI: 10.14419/IJBAS.V5I4.5739
R. Palomino-Merino, R. Lozada-morales, J. Martínez-Juárez, G. Juarez-Díaz, J. Carmona-Rodríguez, P. Angel, S. Jiménez-Sandoval, S. Tomás, O. Zelaya-Ángel, V. Castaño
Nanocrystalline Er-doped TiO2 was prepared by sol-gel at room temperature. X-ray diffraction, photoacoustic spectroscopy (optical absorption), transmission electron microscopy (TEM), and electron dispersion microscopy (EDS) were carried out on both as-prepared and thermally-annealed (air at 700 oC) samples, revealing the anatase crystalline phase of TiO2. The samples exhibit an average grain size from 38 to 5.1 nm, as the nominal concentration of Er varies from 0 % to 7 %. The photoacoustic spectra evidence the absorption edge at 300 nm attributed to TiO2, as well as several electronic transitions which are atomic energy absorption-line levels characteristics of Er.
采用溶胶-凝胶法制备了掺杂铒的纳米TiO2。对制备样品和热退火样品(700℃空气)进行x射线衍射、光声光谱(光吸收)、透射电镜(TEM)和电子色散显微镜(EDS)分析,揭示了TiO2的锐钛矿晶相。当Er的标称浓度从0%到7%变化时,样品的平均晶粒尺寸为38 ~ 5.1 nm。光声光谱证明了TiO2在300 nm处的吸收边缘,以及几个电子跃迁,这些电子跃迁是Er的原子能量吸收谱线特征。
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引用次数: 0
Non-thermal microwave radiation-induced brain tissue dehydration as a potential factor for brain functional impairment 非热微波辐射引起的脑组织脱水是脑功能损伤的潜在因素
Pub Date : 2016-09-23 DOI: 10.14419/IJBAS.V5I4.6430
A. Nikoghosyan, Armenuhi Heqimyan, S. Ayrapetyan
Based on our previous finding that metabolically controlled cell hydration is sensitive to the changes of physicochemical properties of cell aqua medium, which take place upon the effect of weak physical signals, including microwaves with non-thermal intensity (NT MW), it has been hypothesized that cell aqua medium serves as a primary target for NT MW effect on brain tissue. To elucidate the nature of the metabolic pathway through which the effect of NT MW-induced changes of physicochemical properties of cell aqua medium modulate cell hydration, the effects of intraperitoneal (IP) injection of PS treated by NT MW on brain tissue hydration, 45 Ca 2+ uptake, [ 3 H]-ouabain binding with cell membrane and intracellular cyclic nucleotides have been studied. The obtained data indicate that PS treated by NT MW through the activation of high affinity ouabain receptors in membrane stimulates cAMP-dependent Na + /Ca 2+ exchange in reverse mode (R), which leads to brain tissue hydration in healthy (young) and dehydration in non-healthy (old) rats. As NT MW radiation-induced activation of R Na + /Ca 2+ exchange leads to the increase of intracellular Ca 2+ ([Ca 2+ ] i), it is considered as a potential factor leading to the brain functional impairment, especially when brain metabolic activity is depressed (e.g. during aging).
基于我们之前的发现,代谢控制的细胞水化对细胞水介质的物理化学性质的变化很敏感,这些变化是在弱物理信号的作用下发生的,包括非热强度的微波(NT MW),我们假设细胞水介质是NT MW对脑组织作用的主要靶点。为了阐明NT MW诱导的细胞水介质理化性质改变调节细胞水化作用的代谢途径的本质,我们研究了NT MW处理的PS腹腔注射对脑组织水化、45 ca2 +摄取、[3 H]-瓦巴因与细胞膜结合以及细胞内环核苷酸的影响。结果表明,NT MW通过激活膜内高亲和力的瓦巴因受体,刺激camp依赖性的Na + / ca2 +反向交换(R),导致健康(年轻)大鼠脑组织水化,而非健康(老年)大鼠脑组织脱水。由于NT MW辐射诱导的R Na + / ca2 +交换激活导致细胞内ca2 + ([ca2 +] i)增加,因此被认为是导致脑功能损伤的潜在因素,特别是当脑代谢活性下降时(如衰老)。
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引用次数: 3
Chebyshev neural network model with linear and nonlinear active functions 具有线性和非线性主动函数的切比雪夫神经网络模型
Pub Date : 2016-09-10 DOI: 10.14419/IJBAS.V5I3.6382
S. S. Chaharborj, Y. Mahmoudi
In this paper the second order non-linear ordinary differential equations of Lane-Emden type as singular initial value problems using Chebyshev Neural Network (ChNN) with linear and nonlinear active functions has been studied. Active functions as, (texttt{F(z)=z}, texttt{sinh(x)}, texttt{tanh(z)}) are considered to find the numerical results with high accuracy. Numerical results from Chebyshev Neural Network shows that linear active function has more accuracy and is more convenient compare to other functions.
本文利用具有线性和非线性主动函数的切比雪夫神经网络研究了二阶非线性Lane-Emden型常微分方程的奇异初值问题。为了得到精度较高的数值结果,考虑了(texttt{F(z)=z}, texttt{sinh(x)}, texttt{tanh(z)})等主动函数。切比雪夫神经网络的数值结果表明,与其他函数相比,线性主动函数具有更高的精度和方便性。
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引用次数: 3
Shifting Use of Auditing:Tool of Strategic Financial Management to Assure Consistency of Financial Solution 转换使用审计:战略财务管理工具以确保财务解决方案的一致性
Pub Date : 2016-09-01 DOI: 10.21904/WEKEN/2016/V1/I3/103460
Abbas Lokhandwala
Development and performance of auditing required management and the control panel to insure consistency of financial solutions with established targets, achievement of goals as also the legal compliance. Yet, in spite all this, India loses billions of dollars to fraud each year. Since the peak body of auditors does not take the responsibility of fraud, there is need of a new milestone in the maturation of the auditing function called Forensic Auditing. This can assist an entity improve the bottom line without manipulating the financial statements. Preventive health checkup of finances to identify frauds is the demand of the hour. Forensic auditing principles carry the ability to demystify the financial uncertainties coming in the direction of organizations goals and aims, thereby making them a competitive edge over others. The researcher will attempt to integrate views of listeners and employees on this topic. The aim of this paper is to give a new relevance to auditing by going beyond numbers and to build a transparent corporate culture by incorporating forensic accounting principles therein.
开发和执行审计要求管理层和控制小组,以确保财务解决方案与既定目标的一致性,目标的实现以及法律的合规性。然而,尽管如此,印度每年仍因欺诈损失数十亿美元。由于审计人员的最高主体不承担欺诈责任,因此在审计职能的成熟过程中需要一个新的里程碑,即法务审计。这可以帮助企业在不操纵财务报表的情况下提高利润。对财务状况进行预防性健康检查以识别欺诈行为是当前的需求。法务审计原则具有揭秘在组织目标和目的方向上出现的财务不确定性的能力,从而使它们比其他组织具有竞争优势。研究人员将尝试整合听众和员工对这个话题的看法。本文的目的是通过超越数字,赋予审计新的相关性,并通过将法务会计原则纳入其中,建立透明的企业文化。
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引用次数: 0
Operation Management Strategies Implemented in Manufacturing Companies: Review of Literature 制造企业实施营运管理策略:文献回顾
Pub Date : 2016-09-01 DOI: 10.21904/WEKEN/2016/V1/I3/103462
P. Shelar
Operations management techniques become the core of what excellence in means of manufacturing lies in the case of all industries in to manufacturing domain. The different systems and processes used in organizations have evolved and build on solid foundations of various inventions and innovations in techniques and process involved in creating a most accepted and applicable solution which will result in 'value' to the organizations. There has been existing research and literature pertaining to this topic is widely used as a base for researchers in developing new concepts and processes. This research paper aims to explore the existing research in the field of operations management from an academic point of view as well as aims at providing potential scope of academic inquiry in relations to the topic. Various disciplines of operations management such as ERP, TOC, JIT, VAE, and Lean Sig Sigma, etc. are being analyses and further opportunities in those areas are being suggested. Also an effort is being made to enquire and analyze about the possibility of an integrated approach being proposed earlier, if not aids to suggest on the logical development which could be associated with implementation of operations management in manufacturing industries as well as service organizations.
在制造领域的所有行业中,运营管理技术成为卓越制造手段的核心。组织中使用的不同系统和过程已经发展并建立在各种技术和过程的发明和创新的坚实基础上,这些发明和创新涉及创建最被接受和适用的解决方案,这些解决方案将为组织带来“价值”。已经有关于这一主题的现有研究和文献被广泛用作研究人员开发新概念和新工艺的基础。本研究论文旨在从学术角度探讨运营管理领域的现有研究,并旨在提供与该主题相关的潜在学术探究范围。各种操作管理的学科,如ERP、TOC、JIT、VAE和精益西格玛等正在被分析,并在这些领域提出了进一步的机会。此外,正在努力询问和分析先前提出的综合办法的可能性,如果不是协助就可能与制造业和服务组织的业务管理的执行有关的逻辑发展提出建议。
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引用次数: 0
期刊
International Journal of Sciences: Basic and Applied Research
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