Pub Date : 2023-07-11DOI: 10.18203/issn.2455-4529.intjresdermatol20232154
Mariana Elguezabal Riojas
Psoriasis is a chronic skin disease that affects millions of people worldwide. Its etiology is not yet fully understood, but it is thought to be related to a combination of genetic, immunological and environmental factors. In this literature review article, several relevant scientific studies and publications will be analyzed to provide an overview of psoriasis treatment. Aspects such as epidemiology, the significance of the disease, the theoretical framework that includes definition, diagnosis, treatment and complications will be addressed, and conclusions based on the available evidence will be presented.
{"title":"Psoriasis treatment: a literature review","authors":"Mariana Elguezabal Riojas","doi":"10.18203/issn.2455-4529.intjresdermatol20232154","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20232154","url":null,"abstract":"Psoriasis is a chronic skin disease that affects millions of people worldwide. Its etiology is not yet fully understood, but it is thought to be related to a combination of genetic, immunological and environmental factors. In this literature review article, several relevant scientific studies and publications will be analyzed to provide an overview of psoriasis treatment. Aspects such as epidemiology, the significance of the disease, the theoretical framework that includes definition, diagnosis, treatment and complications will be addressed, and conclusions based on the available evidence will be presented.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90698559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231834
Sharad Chaurasia, Ipshita Bhattacharya, Kanchan Dhaka, P. Gupta, Paschal Dsouza
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis frequently related to chronic inflammatory bowel disease (IBD) and often associated with exacerbation of intestinal disease and/or loss of treatment efficacy. The mainstay of treatment is long-term immunosuppression, often with high doses of corticosteroids or low doses of ciclosporin. PG has been reported to respond to TNF alpha inhibitors. We report a patient of recalcitrant PG who responded very well to treatment with golimumab. A 61-year-old known case of PG since 4 years, who also had history of hypertension, pulmonary TB (treated), had been treated with dapsone, thalidomide, colchicine and corticosteroids in the past with partial response and frequent relapses. In February 2021, the patient while being on low-dose oral corticosteroids and colchicine, presented with large painful ulcer over back of his right thigh, which rapidly worsened. In agreement with the pulmonologist, the patient was started on Injection golimumab in addition to intravenous dexamethasone with slow tapering of steroid dosage following the improvement of the cutaneous lesion. Patient reported a near-total resolution of lesion after two doses. He is maintaining well with golimumab. PG can be poorly responsive despite adequate treatment with conventional modalities. High dose steroid therapy with all expected iatrogenic complications and treatment with cyclosporine in such an elderly patient with hypertension and history of tuberculosis seemed to be inappropriate. For all these reasons, a treatment with the TNF alpha inhibitor golimumab, appeared to be the most reasonable therapeutic choice for a patient.
{"title":"Conquering pyoderma gangrenosum: exploring non-steroidal treatment options","authors":"Sharad Chaurasia, Ipshita Bhattacharya, Kanchan Dhaka, P. Gupta, Paschal Dsouza","doi":"10.18203/issn.2455-4529.intjresdermatol20231834","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231834","url":null,"abstract":"Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis frequently related to chronic inflammatory bowel disease (IBD) and often associated with exacerbation of intestinal disease and/or loss of treatment efficacy. The mainstay of treatment is long-term immunosuppression, often with high doses of corticosteroids or low doses of ciclosporin. PG has been reported to respond to TNF alpha inhibitors. We report a patient of recalcitrant PG who responded very well to treatment with golimumab. A 61-year-old known case of PG since 4 years, who also had history of hypertension, pulmonary TB (treated), had been treated with dapsone, thalidomide, colchicine and corticosteroids in the past with partial response and frequent relapses. In February 2021, the patient while being on low-dose oral corticosteroids and colchicine, presented with large painful ulcer over back of his right thigh, which rapidly worsened. In agreement with the pulmonologist, the patient was started on Injection golimumab in addition to intravenous dexamethasone with slow tapering of steroid dosage following the improvement of the cutaneous lesion. Patient reported a near-total resolution of lesion after two doses. He is maintaining well with golimumab. PG can be poorly responsive despite adequate treatment with conventional modalities. High dose steroid therapy with all expected iatrogenic complications and treatment with cyclosporine in such an elderly patient with hypertension and history of tuberculosis seemed to be inappropriate. For all these reasons, a treatment with the TNF alpha inhibitor golimumab, appeared to be the most reasonable therapeutic choice for a patient.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73893688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231830
J. M. Pereira de Godoy, L. M. Pereira de Godoy
Lymphedema is a clinical condition in which an accumulation of macromolecules occurs in the interstitial space and an atypical evolution known as elephantiasis nostras verrucosa may occur. The objective of this study is to report on the clinical evolution and analysis of the progression of a 56-year-old patient with a diagnosis of primary bilateral stage II lymphoedema. With an atypical presentation of it, identified as elephantiasis nostra verrucosa. The patient had suffered from lymphoestatic edema since he was 10 years old, having previously received ineffective treatments until he arrived at the Clinica Godoy in Sao Jose de Rio Preto Brazil, where he underwent an intensive therapy procedure treatment model proposed by Godoy and Godoy; in which favorable results were obtained in a short period of time. Lymphedema is a chronic disease that is manageable but not curable. It is also difficult to be treated, especially if it has progressed to a late stage such as elephantiasis nostras verrucosa associated the continuous and repetitive infectious and inflammatory processes over time must have contributed to the evolution of the fibrotic pattern. Intensive treatment based on the Godoy method® is possible reduce in short period of time the volume and improve fibrosis and quality of life this patient.
{"title":"Elephantiasis nostras verrucosa: case report","authors":"J. M. Pereira de Godoy, L. M. Pereira de Godoy","doi":"10.18203/issn.2455-4529.intjresdermatol20231830","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231830","url":null,"abstract":"Lymphedema is a clinical condition in which an accumulation of macromolecules occurs in the interstitial space and an atypical evolution known as elephantiasis nostras verrucosa may occur. The objective of this study is to report on the clinical evolution and analysis of the progression of a 56-year-old patient with a diagnosis of primary bilateral stage II lymphoedema. With an atypical presentation of it, identified as elephantiasis nostra verrucosa. The patient had suffered from lymphoestatic edema since he was 10 years old, having previously received ineffective treatments until he arrived at the Clinica Godoy in Sao Jose de Rio Preto Brazil, where he underwent an intensive therapy procedure treatment model proposed by Godoy and Godoy; in which favorable results were obtained in a short period of time. Lymphedema is a chronic disease that is manageable but not curable. It is also difficult to be treated, especially if it has progressed to a late stage such as elephantiasis nostras verrucosa associated the continuous and repetitive infectious and inflammatory processes over time must have contributed to the evolution of the fibrotic pattern. Intensive treatment based on the Godoy method® is possible reduce in short period of time the volume and improve fibrosis and quality of life this patient.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75352918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231828
Jhini Nayak, K. Bhatia, C. Namdeo
Alopecia areata (AA) is associated with impairment of psychological health being more pronounced in pediatric population. Hence, it becomes imperative to study the AA in pediatric population so that early diagnosis and adequate treatment can be initiated at early stage to prevent further morbidity associated with the condition. This observational study was conducted in the department of dermatology venereology and leprosy, SAIMS and PG institute, Indore, India after obtaining approval from the IEC. The study included 14 children with AA who visited the hospital over the period of 1 year. Results showed that Mean age of the patients was 8.8±3.423 years with M:F ratio of 3:4. AA subtotalis was found to be most frequent (57.1%). The mean duration of alopecia was reported to be 9.3±7.965 months. The most common finding was the presence of a single patch (35.7%) and 50% of subjects have had a single episode of the disease. 64.3% of children had involvement of multiple sites with scalp being the most common (85.7%). There is high prevalence of markers of disease severity and activity amongst pediatric patients with AA. High prevalence of nail changes, mark hair (64.3%), coudability hair (50.0%), yellow dots (42.8.0%), black dots (78.6%), S. vellus hair (28.6%) shows that children have high chance of AA progressing to severe forms. There is high prevalence of markers of disease severity and activity amongst pediatric patients with AA with AA subtotalis more common among children as compared to the patchy type.
{"title":"Assessment of prognostic markers of alopecia areata in pediatric patients","authors":"Jhini Nayak, K. Bhatia, C. Namdeo","doi":"10.18203/issn.2455-4529.intjresdermatol20231828","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231828","url":null,"abstract":"Alopecia areata (AA) is associated with impairment of psychological health being more pronounced in pediatric population. Hence, it becomes imperative to study the AA in pediatric population so that early diagnosis and adequate treatment can be initiated at early stage to prevent further morbidity associated with the condition. This observational study was conducted in the department of dermatology venereology and leprosy, SAIMS and PG institute, Indore, India after obtaining approval from the IEC. The study included 14 children with AA who visited the hospital over the period of 1 year. Results showed that Mean age of the patients was 8.8±3.423 years with M:F ratio of 3:4. AA subtotalis was found to be most frequent (57.1%). The mean duration of alopecia was reported to be 9.3±7.965 months. The most common finding was the presence of a single patch (35.7%) and 50% of subjects have had a single episode of the disease. 64.3% of children had involvement of multiple sites with scalp being the most common (85.7%). There is high prevalence of markers of disease severity and activity amongst pediatric patients with AA. High prevalence of nail changes, mark hair (64.3%), coudability hair (50.0%), yellow dots (42.8.0%), black dots (78.6%), S. vellus hair (28.6%) shows that children have high chance of AA progressing to severe forms. There is high prevalence of markers of disease severity and activity amongst pediatric patients with AA with AA subtotalis more common among children as compared to the patchy type.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79682864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231832
Pradnya Asutkar, S. Pande
Small-vessel vasculitis is a rare immunological disease that affects arterioles, capillaries and venules. A 1-year-6-month-old male of non-consanguineous marriage came to the OPD with his mother with a complaint of swelling over bilateral legs for 3 days and rash over his body for 1 day. The swelling was increasing and gradually ascending upward. Systemic examination revealed S1, S2 +, and no murmur in CVS. Soft, NT, liver, spleen not palpable. The patient was admitted and routine investigations were sent. The case reported above had clinical spectrum with skin involvement as palpable purpura, nervous system involvement as peripheral neuropathy and proximal myopathy and hematological involvement, gastrointestinal involvement as vague abdominal pain.
{"title":"Small vessel vasculitis: a rare case report","authors":"Pradnya Asutkar, S. Pande","doi":"10.18203/issn.2455-4529.intjresdermatol20231832","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231832","url":null,"abstract":"Small-vessel vasculitis is a rare immunological disease that affects arterioles, capillaries and venules. A 1-year-6-month-old male of non-consanguineous marriage came to the OPD with his mother with a complaint of swelling over bilateral legs for 3 days and rash over his body for 1 day. The swelling was increasing and gradually ascending upward. Systemic examination revealed S1, S2 +, and no murmur in CVS. Soft, NT, liver, spleen not palpable. The patient was admitted and routine investigations were sent. The case reported above had clinical spectrum with skin involvement as palpable purpura, nervous system involvement as peripheral neuropathy and proximal myopathy and hematological involvement, gastrointestinal involvement as vague abdominal pain.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72880410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231833
Janani R., R. Menon, Brinda G. David
Syringocystadenoma papilliferum is a rare benign adnexal tumour presenting as exuberant proliferating lesion showing differentiation in apocrine pattern. The three clinical variants are linear, plaque and solitary of which linear variant is the rarest. We report a case of linear variant of syringocystadenoma papilliferum, which had typical histopathological features. As there is risk of malignancy in long standing cases, early diagnosis and treatment is of utmost importance.
{"title":"Linear syringocystadenoma papilliferum of neck: a rare variant adnexal tumour","authors":"Janani R., R. Menon, Brinda G. David","doi":"10.18203/issn.2455-4529.intjresdermatol20231833","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231833","url":null,"abstract":"Syringocystadenoma papilliferum is a rare benign adnexal tumour presenting as exuberant proliferating lesion showing differentiation in apocrine pattern. The three clinical variants are linear, plaque and solitary of which linear variant is the rarest. We report a case of linear variant of syringocystadenoma papilliferum, which had typical histopathological features. As there is risk of malignancy in long standing cases, early diagnosis and treatment is of utmost importance.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79330608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231827
Gajendra Muzalda, K. Bhatia, C. Namdeo
Background: Adequate knowledge about nail changes in the geriatric population can help in the early identification and timely treatment of underlying disease adding to the quality of life of the elderly population with nail concerns. The present study is aimed to study the clinico-epidemiological profile and onychoscopic pattern of nail disorders in geriatric populations. Methods: This observational study included 100 subjects aged 60 years or more. Clinical examination and onychoscopic examination by Dermlite DL4 dermoscope with 10x magnification of the nail bed, nail plate, nail fold, and hyponychium in all the 20 nails were done. Even single positive findings in a single nail are considered in the study. If clinically suspected of onychomycosis, 20% potassium hydroxide mount was performed to identify fungal elements. Results: Mean age of the subjects was 66.27±5.546 years. Male: female ratio was 2.1:1. Mean duration of complaints pertaining to nail changes was 4.7±3.864 years. The damaged cuticles were the universal finding in all the subjects (100%) in nail fold examination, nail dystrophy and longitudinal ridges were seen in all [100.0%)] subjects of nail plate examination. The most frequently observed change in nail bed has been splinter haemorrhage [26% versus. 32%] and in hyponychium was subungual hyperkeratosis [36% versus 37.0%] clinically and dermoscopically respectively. Onychomycosis was diagnosed in 25% of total subjects. Conclusions: Onychoscopy is an important, non-invasive modality to identify and diagnose the nail changes earlier which helps in managing the disease earlier.
{"title":"Clinico-epidemiological profile and onychoscopic pattern of nail disorders in geriatric population","authors":"Gajendra Muzalda, K. Bhatia, C. Namdeo","doi":"10.18203/issn.2455-4529.intjresdermatol20231827","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231827","url":null,"abstract":"Background: Adequate knowledge about nail changes in the geriatric population can help in the early identification and timely treatment of underlying disease adding to the quality of life of the elderly population with nail concerns. The present study is aimed to study the clinico-epidemiological profile and onychoscopic pattern of nail disorders in geriatric populations.\u0000Methods: This observational study included 100 subjects aged 60 years or more. Clinical examination and onychoscopic examination by Dermlite DL4 dermoscope with 10x magnification of the nail bed, nail plate, nail fold, and hyponychium in all the 20 nails were done. Even single positive findings in a single nail are considered in the study. If clinically suspected of onychomycosis, 20% potassium hydroxide mount was performed to identify fungal elements.\u0000Results: Mean age of the subjects was 66.27±5.546 years. Male: female ratio was 2.1:1. Mean duration of complaints pertaining to nail changes was 4.7±3.864 years. The damaged cuticles were the universal finding in all the subjects (100%) in nail fold examination, nail dystrophy and longitudinal ridges were seen in all [100.0%)] subjects of nail plate examination. The most frequently observed change in nail bed has been splinter haemorrhage [26% versus. 32%] and in hyponychium was subungual hyperkeratosis [36% versus 37.0%] clinically and dermoscopically respectively. Onychomycosis was diagnosed in 25% of total subjects.\u0000Conclusions: Onychoscopy is an important, non-invasive modality to identify and diagnose the nail changes earlier which helps in managing the disease earlier.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79351926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231829
M. Asermouh, C. A. Khabba, Z. Mehsas, S. Derqaoui, K. Znati, M. Meziane
Benign lichenoid keratosis is a rarely described entity in the literature. It is believed to correspond to a process of clearance of a solar lentigo or a seborrheic keratosis that must be confirmed on histology. The clinical and dermoscopic presentations are very variable from one subject to another and according to the stage of progression. In our case, its localization on the umbilicus with a grayish-black clinical aspect and a doubtful dermoscopy is not only original, but led us to wrongly think of a malignant tumor and to perform an anatomopathological examination that helped to re-establish the diagnosis.
{"title":"Lichen planus like keratosis: little known and misleading etiology of pigmented skin lesion","authors":"M. Asermouh, C. A. Khabba, Z. Mehsas, S. Derqaoui, K. Znati, M. Meziane","doi":"10.18203/issn.2455-4529.intjresdermatol20231829","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231829","url":null,"abstract":"Benign lichenoid keratosis is a rarely described entity in the literature. It is believed to correspond to a process of clearance of a solar lentigo or a seborrheic keratosis that must be confirmed on histology. The clinical and dermoscopic presentations are very variable from one subject to another and according to the stage of progression. In our case, its localization on the umbilicus with a grayish-black clinical aspect and a doubtful dermoscopy is not only original, but led us to wrongly think of a malignant tumor and to perform an anatomopathological examination that helped to re-establish the diagnosis.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79507436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231824
A. Pandey, Aayushi Mohan, Prannav Satyaraj
Background: Treatment of vitiligo remains a challenge and there is no universal consensus about optimal treatment. Platelet rich plasma contains several growth factors and is being used as an effective treatment of several dermatological disorders. Now it is clear that along with melanocytes, keratinocytes and fibroblasts are also involved in pathogenesis of vitiligo. The aim of this study was to compare the effect of narrowband-ultraviolet B (NB-UVB) with platelet rich plasma versus NB-UVB and intralesional normal saline in treatment of vitiligo. Methods: A prospective observational study was done between March 2016 to August 2017 on patients of vitiligo attending BRD Medical College, Gorakhpur. A total of 80 patients were enrolled with symmetrical lesions. For each patient one side was treated with NB-UVB along with intralesional platelet-rich plasma (PRP) and other side with NB- UVB plus intralesional normal saline was given. Intralesional PRP and intralesional normal saline was given on an interval of every 2 weeks for 4 months and patients were receiving NB-UVB therapy thrice weekly on alternate day. Results: We found that combination of PRP with NB UVB had statistically significant improvement as compared to NB UVB alone with pigmentation detected in 60% patient in combined site versus 20% in NB UVB plus intralesional normal saline. Conclusions: Intradermal PRP injections along with NB-UVB are efficacious, safe, cheap and easy technique in treatment of vitiligo it is more efficacious when compared to NB-UVB therapy. It also shortens the duration of NB-UVB therapy.
{"title":"A comparative study of narrowband-ultraviolet B plus intralesional normal saline versus narrowband-ultraviolet B with platelet rich plasma in treatment of vitiligo","authors":"A. Pandey, Aayushi Mohan, Prannav Satyaraj","doi":"10.18203/issn.2455-4529.intjresdermatol20231824","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231824","url":null,"abstract":"Background: Treatment of vitiligo remains a challenge and there is no universal consensus about optimal treatment. Platelet rich plasma contains several growth factors and is being used as an effective treatment of several dermatological disorders. Now it is clear that along with melanocytes, keratinocytes and fibroblasts are also involved in pathogenesis of vitiligo. The aim of this study was to compare the effect of narrowband-ultraviolet B (NB-UVB) with platelet rich plasma versus NB-UVB and intralesional normal saline in treatment of vitiligo.\u0000Methods: A prospective observational study was done between March 2016 to August 2017 on patients of vitiligo attending BRD Medical College, Gorakhpur. A total of 80 patients were enrolled with symmetrical lesions. For each patient one side was treated with NB-UVB along with intralesional platelet-rich plasma (PRP) and other side with NB- UVB plus intralesional normal saline was given. Intralesional PRP and intralesional normal saline was given on an interval of every 2 weeks for 4 months and patients were receiving NB-UVB therapy thrice weekly on alternate day.\u0000Results: We found that combination of PRP with NB UVB had statistically significant improvement as compared to NB UVB alone with pigmentation detected in 60% patient in combined site versus 20% in NB UVB plus intralesional normal saline.\u0000Conclusions: Intradermal PRP injections along with NB-UVB are efficacious, safe, cheap and easy technique in treatment of vitiligo it is more efficacious when compared to NB-UVB therapy. It also shortens the duration of NB-UVB therapy.","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74452626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-26DOI: 10.18203/issn.2455-4529.intjresdermatol20231825
Manjari Bundela, K. Bhatia, M. Bhandari, C. Namdeo, Swati Gupta
Background: Obesity being a multi-organ disease also affects the skin. Bariatric surgery results in the improvement or remission of many obesity-related comorbid conditions, as well as sustained weight loss and improvement in quality of life. After bariatric surgery, both positive and negative impacts on the skin are seen. Studies have reported improvement in many skin conditions. The present study was conducted with the aim to find cutaneous changes in obese patients before and after bariatric surgery were assessed. Methods: This prospective, observational study included 61 obese subjects who had undergone bariatric surgery. clinical findings of skin, nails, and hair before and after bariatric surgery at 3 months, 6 months, and 9 months follow-up were also recorded. Results: Mean age of the subjects was 44.4±13.284 years. Bariatric surgery resulted in a significant decrease in BMI [40.3 (38.25-42.70) vs 32.0 (30-35) kg/m2]. The median of % effective BMI change was 20.46% (17.12%-24.66%) kg/m2. Amongst obese subjects, the most frequently seen skin condition was acanthosis nigricans [17 (27.9%)] followed by acrochordon [15 (24.6%)] and intertrigo [10 (16.4%)]. Our study showed no significant difference in the prevalence of various skin conditions/diseases before and after the bariatric surgery except for intertrigo, tinea corporis, and striae rubra. Conclusions: various skin/hair/nail conditions and/or diseases develop amongst obese individuals, acanthosis nigricans, acrochordon, intertrigo, seborrheic dermatitis, chronic telogen effluvium, onychomycosis, and longitudinal ridges are common. Weight loss after bariatric surgery provided improvement in skin conditions/diseases.
{"title":"Cutaneous changes in obese patients before and after bariatric surgery","authors":"Manjari Bundela, K. Bhatia, M. Bhandari, C. Namdeo, Swati Gupta","doi":"10.18203/issn.2455-4529.intjresdermatol20231825","DOIUrl":"https://doi.org/10.18203/issn.2455-4529.intjresdermatol20231825","url":null,"abstract":"Background: Obesity being a multi-organ disease also affects the skin. Bariatric surgery results in the improvement or remission of many obesity-related comorbid conditions, as well as sustained weight loss and improvement in quality of life. After bariatric surgery, both positive and negative impacts on the skin are seen. Studies have reported improvement in many skin conditions. The present study was conducted with the aim to find cutaneous changes in obese patients before and after bariatric surgery were assessed.\u0000Methods: This prospective, observational study included 61 obese subjects who had undergone bariatric surgery. clinical findings of skin, nails, and hair before and after bariatric surgery at 3 months, 6 months, and 9 months follow-up were also recorded.\u0000Results: Mean age of the subjects was 44.4±13.284 years. Bariatric surgery resulted in a significant decrease in BMI [40.3 (38.25-42.70) vs 32.0 (30-35) kg/m2]. The median of % effective BMI change was 20.46% (17.12%-24.66%) kg/m2. Amongst obese subjects, the most frequently seen skin condition was acanthosis nigricans [17 (27.9%)] followed by acrochordon [15 (24.6%)] and intertrigo [10 (16.4%)]. Our study showed no significant difference in the prevalence of various skin conditions/diseases before and after the bariatric surgery except for intertrigo, tinea corporis, and striae rubra.\u0000Conclusions: various skin/hair/nail conditions and/or diseases develop amongst obese individuals, acanthosis nigricans, acrochordon, intertrigo, seborrheic dermatitis, chronic telogen effluvium, onychomycosis, and longitudinal ridges are common. Weight loss after bariatric surgery provided improvement in skin conditions/diseases. ","PeriodicalId":14331,"journal":{"name":"International Journal of Research in Dermatology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81589815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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