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Gut microbiome as a treatment in colorectal cancer. 将肠道微生物组作为结直肠癌的治疗手段。
IF 5 4区 医学 Q1 Medicine Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/08830185.2024.2312294
Murad Khan, Suleman Shah, Wahid Shah, Ikram Khan, Hamid Ali, Ijaz Ali, Riaz Ullah, Xiufang Wang, Arshad Mehmood, Yanli Wang

Background: The gut microbiome plays a role in the development and progression of colorectal cancer (CRC).

Aim and objective: This review focuses on whether the gut microbiome is involved in the development and regulation of the host immune system.

Methods: The gut microbiome can influence the production and activity of immune cells and molecules that help to maintain the integrity of the intestinal barrier and prevent inflammation. Gut microbiota modulates the anti-cancer immune response. The gut microbiota can influence the function of immune cells, like T cells, that recognize and eliminate cancer cells. Gut microbiota can affect various aspects of cancer progression and the efficacy of various anti-cancer treatments.

Results: Gut microbiota provide promise as a potential biomarker to identify the effect of immunotherapy and as a target for modulation to improve the efficacy of immunotherapy in CRC treatment.

Conclusion: The potential synergistic effect between the gut microbiome and anti-cancer treatment modalities provides an interest in developing strategies to modulate the gut microbiome to improve the efficacy of anti-cancer treatment.

背景:肠道微生物组在结肠直肠癌(CRC)的发生和发展过程中发挥着作用:本综述重点探讨肠道微生物组是否参与宿主免疫系统的发育和调节:肠道微生物群可影响免疫细胞和分子的产生与活性,从而帮助维持肠道屏障的完整性并预防炎症。肠道微生物群调节抗癌免疫反应。肠道微生物群能影响免疫细胞(如 T 细胞)的功能,而 T 细胞能识别并消灭癌细胞。肠道微生物群可影响癌症进展的各个方面以及各种抗癌疗法的疗效:结果:肠道微生物群有望成为识别免疫疗法效果的潜在生物标志物,也有望成为提高免疫疗法在 CRC 治疗中疗效的调节靶点:结论:肠道微生物群与抗癌治疗方法之间的潜在协同作用,为制定调节肠道微生物群的策略以提高抗癌治疗效果提供了兴趣所在。
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引用次数: 0
Circulating and intestinal regulatory T cells in inflammatory bowel disease: A systemic review and meta-analysis. 炎症性肠病中的循环和肠道调节性 T 细胞:系统回顾与荟萃分析
IF 4.3 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-01-01 Epub Date: 2023-08-24 DOI: 10.1080/08830185.2023.2249525
Shihao Duan, Yubin Cao, Pingrun Chen, Yi Yang, Yan Zhang

Regulatory T cells (Tregs) play an important immunosuppressive role in inflammatory bowel disease (IBD). However, findings on the quantitative and functional changes of intestinal and circulating Tregs in patients with IBD are rather contradictory. We therefore conducted a meta-analysis on this issue. The pooled effect was assessed using the standardized mean difference (SMD) with a 95% confidence interval (CI), and subgroup analyses were performed to investigate heterogeneity. This analysis included 764 IBD (402 UC and 362 CD) patients and 341 healthy controls (HCs) pooled from 17 eligible studies. The percentage of circulating Tregs was significantly decreased in active IBD patients compared to HCs (SMD = -0.95, p < 0.001) and inactive IBD patients (SMD = -0.80, p < 0.001). There was no difference in the percentage of circulating Tregs between inactive IBD patients and HCs. The suppressive function of circulating Tregs was impaired in active IBD patients according to limited data (SMD = -0.75, p = 0.02). Besides, the percentage of intestinal Tregs was significantly higher in inflamed regions than in non-inflamed regions (SMD = 0.85, p < 0.001). Our study quantitatively summarized the quantitative and functional changes of Tregs and supported the therapeutic potential of Tregs in IBD. Moreover, additional research into the functions and characteristics of intestinal Tregs in IBD is needed.

调节性 T 细胞(Tregs)在炎症性肠病(IBD)中发挥着重要的免疫抑制作用。然而,有关 IBD 患者肠道和循环 Tregs 数量和功能变化的研究结果却相互矛盾。因此,我们对这一问题进行了荟萃分析。我们使用标准化平均差(SMD)和 95% 置信区间(CI)评估了汇总效应,并进行了亚组分析以研究异质性。该分析纳入了从 17 项符合条件的研究中汇总的 764 名 IBD 患者(402 名 UC 患者和 362 名 CD 患者)和 341 名健康对照组(HCs)。与 HCs 相比,活动性 IBD 患者的循环 Tregs 百分比明显下降(SMD = -0.95,p p = 0.02)。此外,炎症区域的肠道 Tregs 百分比明显高于非炎症区域(SMD = 0.85,p
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引用次数: 0
Platelet extracellular vesicles: Darkness and light of autoimmune diseases. 血小板细胞外囊泡:自身免疫性疾病的黑暗与光明
IF 5 4区 医学 Q1 Medicine Pub Date : 2024-01-01 Epub Date: 2023-06-23 DOI: 10.1080/08830185.2023.2225551
Jingru Chen, Miao Wang, Ying Zhang, Fenglin Zhu, Yanqiu Xu, Guoxiang Yi, Runxiu Zheng, Bin Wu

Autoimmune diseases are characterized by a breakdown of immune tolerance, leading to inflammation and irreversible end-organ tissue damage. Platelet extracellular vesicles are cellular elements that are important in blood circulation and actively participate in inflammatory and immune responses through intercellular communication and interactions between inflammatory cells, immune cells, and their secreted factors. Therefore, platelet extracellular vesicles are the "accelerator" in the pathological process of autoimmune diseases; however, this robust set of functions of platelet extracellular vesicles has also prompted new advances in therapeutic strategies for autoimmune diseases. In this review, we update fundamental mechanisms based on platelet extracellular vesicles communication function in autoimmune diseases. We also focus on the potential role of platelet extracellular vesicles for the treatment of autoimmune diseases. Some recent studies have found that antiplatelet aggregation drugs, specific biological agents can reduce the release of platelet extracellular vesicles. Platelet extracellular vesicles can also serve as vehicles to deliver drugs to targeted cells. It seems that we can try to silence or inhibit microRNA carried by platelet extracellular vesicles transcription and regulate the target cells to treat autoimmune diseases as platelet extracellular vesicles can transfer microRNA to other cells to regulate immune-inflammatory responses. Hopefully, the information presented here will provide hope for patients with autoimmune diseases.

自身免疫性疾病的特点是免疫耐受被破坏,导致炎症和不可逆的终末器官组织损伤。血小板胞外囊泡是血液循环中的重要细胞元素,通过炎症细胞、免疫细胞及其分泌因子之间的细胞间通讯和相互作用,积极参与炎症和免疫反应。因此,血小板胞外囊泡是自身免疫性疾病病理过程的 "加速器";然而,血小板胞外囊泡的这一系列强大功能也促使自身免疫性疾病的治疗策略取得了新进展。在这篇综述中,我们更新了基于血小板胞外囊泡在自身免疫性疾病中沟通功能的基本机制。我们还关注了血小板胞外囊泡在治疗自身免疫性疾病中的潜在作用。最近的一些研究发现,抗血小板聚集药物、特异性生物制剂可以减少血小板胞外囊泡的释放。血小板胞外囊泡还可以作为载体将药物输送到靶细胞。血小板胞外囊泡可以将微RNA转移到其他细胞,从而调节免疫炎症反应,因此我们似乎可以尝试抑制血小板胞外囊泡转录所携带的微RNA,并调节靶细胞,从而治疗自身免疫性疾病。希望本文提供的信息能为自身免疫性疾病患者带来希望。
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引用次数: 0
Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing. 通过单细胞 RNA 测序分析先兆子痫孕妇和产后妇女的免疫细胞图谱。
IF 5 4区 医学 Q1 Medicine Pub Date : 2024-01-01 Epub Date: 2022-11-11 DOI: 10.1080/08830185.2022.2144291
Jing Hu, Qi Guo, Congcong Liu, Qian Yu, Yuan Ren, Yueni Wu, Qin Li, Yuezhen Li, Juntao Liu

Preeclampsia (PE), a leading cause of maternal and fetal morbidity and mortality, is closely related to the immune system alterations. However, little is known about the landscape and heterogeneity of maternal immune system at single-cell level among PE patients. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from three early-onset preeclamptic pregnant women and two healthy control, respectively. Single-cell RNA sequencing was performed on 10× genomics platform and single-cell transcriptomes were obtained to characterize immune cell subgroups at the pregnant and postpartum stages. In total, 80,429 single-cell transcriptomes were obtained. 19 cellular compositions were identified, which were categorized into six cell types including T cells, natural killer (NK) cells, B cells, monocytes, plasmacytoid dendritic cells and conventional dendritic cells. There were excessive activation of B cells, monocytes and NK cells in PE patients at the pregnant stage based on comparative analysis. Lower immune response activation was noticed in CD4+ and CD8+ T cells in PE patients, especially the low-activation of memory T cells at the pregnant and postpartum stages. PE patients showed high activation of B cells in pregnancy persisted postpartum and lower activation of memory T cells, indicating their persistent effects on the pathogenesis and recurrence risk of PE. This study provide a broad characterization of the single-cell transcriptome of PBMCs in PE, which contributes to identification of immune imbalance for its monitoring and treatment.

子痫前期(PE)是导致孕产妇和胎儿发病和死亡的主要原因,与免疫系统的改变密切相关。然而,人们对子痫前期患者的母体免疫系统在单细胞水平上的分布和异质性知之甚少。在这项研究中,研究人员分别从三名早发先兆子痫孕妇和两名健康对照组孕妇体内分离出外周血单核细胞(PBMCs)。在 10× 基因组学平台上进行了单细胞 RNA 测序,并获得了单细胞转录组,以描述怀孕和产后阶段免疫细胞亚群的特征。总共获得了 80 429 个单细胞转录组。共鉴定出 19 种细胞组成,分为六种细胞类型,包括 T 细胞、自然杀伤细胞(NK)、B 细胞、单核细胞、浆细胞树突状细胞和传统树突状细胞。根据比较分析,怀孕阶段的 PE 患者的 B 细胞、单核细胞和 NK 细胞过度活化。PE 患者 CD4+ 和 CD8+ T 细胞的免疫反应活化程度较低,尤其是记忆 T 细胞在怀孕和产后阶段的活化程度较低。PE 患者在妊娠期和产后的 B 细胞活化程度较高,而记忆 T 细胞的活化程度较低,这表明它们对 PE 的发病机制和复发风险具有持续影响。这项研究提供了 PE 患者 PBMCs 单细胞转录组的广泛特征,有助于识别免疫失衡以进行监测和治疗。
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引用次数: 3
HCMV miR-UL70-3p downregulates the rapamycin-induced autophagy by targeting the autophagy-related protein 9A (ATG9A). HCMV miR-UL70-3p 通过靶向自噬相关蛋白 9A (ATG9A) 下调雷帕霉素诱导的自噬。
IF 4.3 4区 医学 Q1 Medicine Pub Date : 2024-01-01 Epub Date: 2024-01-02 DOI: 10.1080/08830185.2023.2296488
Raj Kumar Khalko, Abhishek Pandeya, Sangeeta Saxena, Sunil Babu Gosipatala

Human cytomegalovirus (HCMV) is a representative β-herpesvirus that establishes persistent infections in humans, and exhibits high seropositivity rates in adults. It has co-evolved with its human host and employs various strategies to evade antiviral mechanisms by utilizing a significant portion of its genome. HCMV-encoded proteins and miRNAs have been implicated in regulating these mechanisms, enabling viral survival within the human body. During viral infections, autophagy, a conserved catabolic process essential for cellular homeostasis, acts as an antiviral defense mechanism. Multiple studies have reported that HCMV can modulate autophagy through its proteins and miRNAs, thereby influencing its survival within the host. In this study, we showed the potential involvement of HCMV miRNAs in cellular autophagy. We employed various bioinformatic tools to predict putative HCMV miRNAs that target autophagy-related genes and their corresponding cellular autophagy genes. Our results show that the 3'UTR of autophagy-related genes, including ATG9A, ATG9B, ATG16L2, SQSTM1, and EIF2AK2, harbors potential binding sites for hcmv-miR-UL70-3p. Experimental manipulation involving ectopic expression of hcmv-miR-UL70-3p demonstrated a significant reduction in rapamycin-induced autophagy, with ATG9A as its functional target. These findings establish that hcmv-miR-UL70-3p acts as an autophagy inhibitor by suppressing the expression of ATG9A.

人类巨细胞病毒(HCMV)是一种具有代表性的β-疱疹病毒,可在人体内形成持续感染,在成人中血清阳性率很高。它与人类宿主共同进化,并利用其基因组的重要部分采用各种策略逃避抗病毒机制。HCMV 编码的蛋白质和 miRNA 与调节这些机制有关,从而使病毒能够在人体内存活。在病毒感染期间,自噬是一种保守的分解代谢过程,对细胞的平衡至关重要,是一种抗病毒防御机制。多项研究表明,HCMV 可通过其蛋白质和 miRNAs 调节自噬,从而影响其在宿主体内的存活。在本研究中,我们发现了 HCMV miRNAs 参与细胞自噬的可能性。我们利用各种生物信息学工具预测了靶向自噬相关基因的推定 HCMV miRNA 及其相应的细胞自噬基因。我们的结果表明,自噬相关基因(包括 ATG9A、ATG9B、ATG16L2、SQSTM1 和 EIF2AK2)的 3'UTR 隐藏着 hcmv-miR-UL70-3p 的潜在结合位点。异位表达 hcmv-miR-UL70-3p 的实验操作表明,雷帕霉素诱导的自噬显著减少,ATG9A 是其功能靶点。这些发现证实,hcmv-miR-UL70-3p 通过抑制 ATG9A 的表达,起到了自噬抑制剂的作用。
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引用次数: 0
Boosting immune responses in lung tumor immune microenvironment: A comprehensive review of strategies and adjuvants. 增强肺部肿瘤免疫微环境中的免疫反应:策略与佐剂综述。
IF 4.3 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-01-01 Epub Date: 2024-03-25 DOI: 10.1080/08830185.2024.2333275
Fei Gao, Xiaoqing You, Liu Yang, Xiangni Zou, Bowen Sui

The immune system has a substantial impact on the growth and expansion of lung malignancies. Immune cells are encompassed by a stroma comprising an extracellular matrix (ECM) and different cells like stromal cells, which are known as the tumor immune microenvironment (TIME). TME is marked by the presence of immunosuppressive factors, which inhibit the function of immune cells and expand tumor growth. In recent years, numerous strategies and adjuvants have been developed to extend immune responses in the TIME, to improve the efficacy of immunotherapy. In this comprehensive review, we outline the present knowledge of immune evasion mechanisms in lung TIME, explain the biology of immune cells and diverse effectors on these components, and discuss various approaches for overcoming suppressive barriers. We highlight the potential of novel adjuvants, including toll-like receptor (TLR) agonists, cytokines, phytochemicals, nanocarriers, and oncolytic viruses, for enhancing immune responses in the TME. Ultimately, we provide a summary of ongoing clinical trials investigating these strategies and adjuvants in lung cancer patients. This review also provides a broad overview of the current state-of-the-art in boosting immune responses in the TIME and highlights the potential of these approaches for improving outcomes in lung cancer patients.

免疫系统对肺部恶性肿瘤的生长和扩展有重大影响。免疫细胞被由细胞外基质(ECM)和不同细胞(如基质细胞)组成的基质所包围,这种基质被称为肿瘤免疫微环境(TIME)。肿瘤免疫微环境的特点是存在免疫抑制因子,这些因子会抑制免疫细胞的功能并扩大肿瘤的生长。近年来,人们开发了许多策略和佐剂来扩大 TIME 中的免疫反应,从而提高免疫疗法的疗效。在这篇综述中,我们概述了目前对肺TIME中免疫逃避机制的认识,解释了免疫细胞的生物学特性以及这些成分上的各种效应物,并讨论了克服抑制性障碍的各种方法。我们强调了新型佐剂的潜力,包括收费样受体(TLR)激动剂、细胞因子、植物化学物质、纳米载体和溶瘤病毒,它们可以增强 TME 中的免疫反应。最后,我们总结了正在进行的研究这些策略和肺癌患者辅助剂的临床试验。这篇综述还概述了目前增强TIME免疫反应的最新技术,并强调了这些方法在改善肺癌患者预后方面的潜力。
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引用次数: 0
Th17 cells: A new target in kidney disease research. Th17 细胞:肾病研究的新目标
IF 4.3 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-01-01 Epub Date: 2024-03-05 DOI: 10.1080/08830185.2024.2321901
Tao Zhang, Hongyan Huo, Yinghui Zhang, Jie Tao, Junzheng Yang, Xianglu Rong, Yiqi Yang

Type 17 T helper (Th17) cells, which are a subtype of CD4+ T helper cells, secrete pro-inflammatory cytokines such as IL-17A, IL-17F, IL-21, IL-22, and GM-CSF, which play crucial roles in immune defence and protection against fungal and extracellular pathogen invasion. However, dysfunction of Th17 cell immunity mediates inflammatory responses and exacerbates tissue damage. This pathological process initiated by Th17 cells is common in kidney diseases associated with renal injury, such as glomerulonephritis, lupus nephritis, IgA nephropathy, hypertensive nephropathy, diabetic kidney disease and acute kidney injury. Therefore, targeting Th17 cells to treat kidney diseases has been a hot topic in recent years. This article reviews the mechanisms of Th17 cell-mediated inflammation and autoimmune responses in kidney diseases and discusses the related clinical drugs that modulate Th17 cell fate in kidney disease treatment.

17 型 T 辅助细胞(Th17)是 CD4+ T 辅助细胞的一种亚型,能分泌促炎细胞因子,如 IL-17A、IL-17F、IL-21、IL-22 和 GM-CSF,在免疫防御和抵御真菌及细胞外病原体入侵方面发挥重要作用。然而,Th17 细胞免疫功能失调会介导炎症反应并加剧组织损伤。在肾小球肾炎、狼疮性肾炎、IgA 肾病、高血压肾病、糖尿病肾病和急性肾损伤等与肾损伤相关的肾脏疾病中,Th17 细胞引发的这一病理过程十分常见。因此,靶向 Th17 细胞治疗肾脏疾病是近年来的热门话题。本文回顾了肾脏疾病中Th17细胞介导的炎症和自身免疫反应的机制,并探讨了调节Th17细胞命运的相关临床药物在肾脏疾病治疗中的应用。
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引用次数: 0
Single-cell RNA sequencing of peripheral blood mononuclear cells from pregnant women with Systemic lupus erythematosus. 对患有系统性红斑狼疮的孕妇的外周血单核细胞进行单细胞 RNA 测序。
IF 4.3 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-01-01 Epub Date: 2024-07-27 DOI: 10.1080/08830185.2024.2376649
Congcong Liu, Zeyang Yu, Yijun Song, Xiaojie Zhang, Jiuliang Zhao, Qian Yu, Mengtao Li, Yuezhen Li, Juntao Liu

Systemic lupus erythematosus (SLE), an autoimmune condition, presents pregnancy-related risks, impacting maternal and fetal health. The immune cell composition and gene expression profiles in pregnant SLE patients, as well as the molecular mechanisms of active SLE patients during pregnancy, remain unclear. In our study, we enrolled 12 patients: three active SLE individuals (SLE-AT group, SLEDAI > 12, non-pregnant women), three inactive SLE individuals (SLE-NP group, SLEDAI ranging 0 to 6, non-pregnant women), three pregnant women with active SLE (SLE-C group, SLEDAI > 12), and three pregnant women with inactive SLE (SLE-NC group, SLEDAI range 0 to 6 score). Transcriptome analysis of peripheral blood mononuclear cells (PBMCs) was conducted using the 10x Genomics technique. We observed upregulation of genes like CCDC15 and TRBV4-2 in T cells and CMPK2, IFIT1, and OAS2 in monocytes in the SLE-C group. Notably, gene sets related to Cell Cycle and IFN Response showed significant differences between the SLE-C and SLE-NC groups in naïve CD8 T cells. Our comparison of immune cell type ratios and transcriptional patterns between active and inactive SLE during pregnancy sheds light on the single-cell level changes in SLE status during pregnancy, offering insights for future SLE prediction and treatment strategies.

系统性红斑狼疮(SLE)是一种自身免疫性疾病,具有与妊娠相关的风险,会影响母体和胎儿的健康。妊娠期系统性红斑狼疮患者的免疫细胞组成和基因表达谱以及活动性系统性红斑狼疮患者在妊娠期间的分子机制仍不清楚。在我们的研究中,我们招募了 12 名患者:3 名活动性系统性红斑狼疮患者(SLE-AT 组,SLEDAI > 12 分,非孕妇)、3 名非活动性系统性红斑狼疮患者(SLE-NP 组,SLEDAI 0-6 分,非孕妇)、3 名活动性系统性红斑狼疮孕妇(SLE-C 组,SLEDAI > 12 分)和 3 名非活动性系统性红斑狼疮孕妇(SLE-NC 组,SLEDAI 0-6 分)。我们使用 10x Genomics 技术对外周血单核细胞(PBMC)进行了转录组分析。我们观察到在 SLE-C 组中,T 细胞中的 CCDC15 和 TRBV4-2 等基因上调,单核细胞中的 CMPK2、IFIT1 和 OAS2 等基因上调。值得注意的是,在 SLE-C 组和 SLE-NC 组的幼稚 CD8 T 细胞中,与细胞周期和 IFN 反应相关的基因组显示出显著差异。我们对孕期活动性和非活动性系统性红斑狼疮的免疫细胞类型比例和转录模式进行的比较,揭示了孕期系统性红斑狼疮状态在单细胞水平上的变化,为未来系统性红斑狼疮的预测和治疗策略提供了启示。
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引用次数: 0
Vaccine design and development: Exploring the interface with computational biology and AI. 疫苗设计与开发:探索计算生物学和人工智能的接口。
IF 4.3 4区 医学 Q2 IMMUNOLOGY Pub Date : 2024-01-01 Epub Date: 2024-07-10 DOI: 10.1080/08830185.2024.2374546
Ananya, Darshan C Panchariya, Anandakrishnan Karthic, Surya Pratap Singh, Ashutosh Mani, Aakash Chawade, Sandeep Kushwaha

Computational biology involves applying computer science and informatics techniques in biology to understand complex biological data. It allows us to collect, connect, and analyze biological data at a large scale and build predictive models. In the twenty first century, computational resources along with Artificial Intelligence (AI) have been widely used in various fields of biological sciences such as biochemistry, structural biology, immunology, microbiology, and genomics to handle massive data for decision-making, including in applications such as drug design and vaccine development, one of the major areas of focus for human and animal welfare. The knowledge of available computational resources and AI-enabled tools in vaccine design and development can improve our ability to conduct cutting-edge research. Therefore, this review article aims to summarize important computational resources and AI-based tools. Further, the article discusses the various applications and limitations of AI tools in vaccine development.

计算生物学涉及在生物学中应用计算机科学和信息学技术来理解复杂的生物数据。它使我们能够大规模地收集、连接和分析生物数据,并建立预测模型。在二十一世纪,计算资源和人工智能(AI)已被广泛应用于生物科学的各个领域,如生物化学、结构生物学、免疫学、微生物学和基因组学,用于处理海量数据以做出决策,包括药物设计和疫苗开发等应用,这也是人类和动物福利的主要关注领域之一。了解疫苗设计和开发中可用的计算资源和人工智能工具,可以提高我们开展前沿研究的能力。因此,这篇综述文章旨在总结重要的计算资源和基于人工智能的工具。此外,文章还讨论了人工智能工具在疫苗开发中的各种应用和局限性。
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引用次数: 0
Breaking the graft-versus-host-disease barrier: Mesenchymal stromal/stem cells as precision healers. 打破移植物抗宿主病屏障:作为精准治疗者的间充质基质/干细胞。
IF 5 4区 医学 Q1 Medicine Pub Date : 2024-01-01 Epub Date: 2023-08-28 DOI: 10.1080/08830185.2023.2252007
Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty, Ranjit Kumar Sahoo, Hridayesh Prakash

Mesenchymal Stromal/Stem Cells (MSCs) are multipotent, non-hematopoietic progenitor cells with a wide range of immune modulation and regenerative potential which qualify them as a potential component of cell-based therapy for various autoimmune/chronic inflammatory ailments. Their immunomodulatory properties include the secretion of immunosuppressive cytokines, the ability to suppress T-cell activation and differentiation, and the induction of regulatory T-cells. Considering this and our interest, we here discuss the significance of MSC for the management of Graft-versus-Host-Disease (GvHD), one of the autoimmune manifestations in human. In pre-clinical models, MSCs have been shown to reduce the severity of GvHD symptoms, including skin and gut damage, which are the most common and debilitating manifestations of this disease. While initial clinical studies of MSCs in GvHD cases were promising, the results were variable in randomized studies. So, further studies are warranted to fully understand their potential benefits, safety profile, and optimal dosing regimens. Owing to these inevitable issues, here we discuss various mechanisms, and how MSCs can be employed in managing GvHD, as a cellular therapeutic approach for this disease.

间充质基质/干细胞(MSCs)是一种多能、非造血祖细胞,具有广泛的免疫调节和再生潜力,是治疗各种自身免疫性/慢性炎症性疾病的细胞疗法的潜在成分。它们的免疫调节特性包括分泌免疫抑制细胞因子、抑制 T 细胞活化和分化的能力以及诱导调节性 T 细胞。考虑到这一点和我们的兴趣,我们在此讨论间充质干细胞对治疗移植物抗宿主疾病(GvHD)(人类自身免疫表现之一)的意义。在临床前模型中,间充质干细胞已被证明能减轻移植物抗宿主病症状的严重程度,包括皮肤和肠道损伤,这也是该病最常见和最令人衰弱的表现。虽然对间叶干细胞治疗风湿性坏死病例的初步临床研究很有希望,但随机研究的结果却不尽相同。因此,有必要开展进一步研究,以充分了解间叶干细胞的潜在益处、安全性和最佳剂量方案。鉴于这些不可避免的问题,我们在此讨论了间充质干细胞的各种机制,以及间充质干细胞如何作为一种细胞治疗方法用于治疗GvHD。
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引用次数: 0
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International Reviews of Immunology
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