Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.8185
K. Majumder, Sumira Mukhia, Urmila Koirala
{"title":"Production Kinetics of Xylanase and Carboxy-methyl Cellulase of Schizophyllum commune in Submerged Fermentation Technique","authors":"K. Majumder, Sumira Mukhia, Urmila Koirala","doi":"10.26438/ijsrbs/v6i2.8185","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.8185","url":null,"abstract":"","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78911871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.133143
A. Parmar, M. R. Patle
Received: 09/Apr/2019, Accepted: 19/Apr/2019, Online: 30/Apr/2019 AbstractIn the drug-design process, structure activity relationship is an important tool for estimation of biological activity of the unknown compounds. In this process, the objective is development of a relationship between structural features of molecules and the property of interest i. e. biological activity. On the basis of this relationship, the biological activity can be predicted for new candidate structures. Initially, the forty two substituted pyrimidine molecules with known biological activities were considered as known set for regression analysis model building purpose. The properties module from Datawarrior used to calculate descriptors. Structure activity model indicates that these descriptors have significant relationships with observed bioactivity. We have observed a high relationship between experimental and predicted activity values, indicating the validation and the excellent quality of the derived model. In the present study, the new substituted pyrimidine molecules are designed, optimized and their descriptors were calculated using Datawarrior modules. Then by using the Regression analysis model, their biological activities are studied as well as inhibition studies for the 1QPQ by molecular docking method are also carried out. Thus on the basis of regression analysis study and docking study of substituted pyrimidine derivatives, we can conclude that these compounds on further studies may prove to be therapeutic agent against tuberculosis.
{"title":"Regression Analysis and Docking Study of Pyrimidine Based Compounds as anti-Tuberculosis Therapeutic Agents","authors":"A. Parmar, M. R. Patle","doi":"10.26438/ijsrbs/v6i2.133143","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.133143","url":null,"abstract":"Received: 09/Apr/2019, Accepted: 19/Apr/2019, Online: 30/Apr/2019 AbstractIn the drug-design process, structure activity relationship is an important tool for estimation of biological activity of the unknown compounds. In this process, the objective is development of a relationship between structural features of molecules and the property of interest i. e. biological activity. On the basis of this relationship, the biological activity can be predicted for new candidate structures. Initially, the forty two substituted pyrimidine molecules with known biological activities were considered as known set for regression analysis model building purpose. The properties module from Datawarrior used to calculate descriptors. Structure activity model indicates that these descriptors have significant relationships with observed bioactivity. We have observed a high relationship between experimental and predicted activity values, indicating the validation and the excellent quality of the derived model. In the present study, the new substituted pyrimidine molecules are designed, optimized and their descriptors were calculated using Datawarrior modules. Then by using the Regression analysis model, their biological activities are studied as well as inhibition studies for the 1QPQ by molecular docking method are also carried out. Thus on the basis of regression analysis study and docking study of substituted pyrimidine derivatives, we can conclude that these compounds on further studies may prove to be therapeutic agent against tuberculosis.","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75557354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.5058
S. Kate, D. Hire, N. Pawar
{"title":"Production and optimization of Polyhydroxybutyrate and its application in bioplastic production","authors":"S. Kate, D. Hire, N. Pawar","doi":"10.26438/ijsrbs/v6i2.5058","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.5058","url":null,"abstract":"","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84866493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.119125
A. Mishra
{"title":"Histopathological changes in liver of fish Channa punctatus (Bloch) exposure in effluents of Bhilai steel plant C.G. (India)","authors":"A. Mishra","doi":"10.26438/ijsrbs/v6i2.119125","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.119125","url":null,"abstract":"","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"331 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82935506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.4349
A. Iqbal, H. Quraishi, Huma, A. Shah, Adil Rashid, Abdur Raheem
Received: 26/Mar/2019, Accepted: 13/Apr/2019, Online: 30/Apr/2019 Abstract— Varicose veins are veins that have become enlarged and twisted and are commonly found in legs. The calf muscles of the leg pumps. The venous blood back to the heart against the gravity. When the veins become varicose the valves do not function properly as the blood flows backwards and the veins engorge. The varicose veins are most common in the superficial veins of legs and due to high pressure while standing the veins engorging and ulceration can occur. Only ten percent of the venous blood in the legs is returned back by superficial veins, hence the surgical removal can be opted for superficial varicose veins. Other modalities of treatment included sclerotherapy, elastic stockings, leg elevation, exercise, radiofrequency ablation, endovascular laser treatment etc. In this study Hirudotherapy has been done at Regional Research Institute of Unani Medicine, Srinagar for the treatment of varicose vein and has been observed that leech relieves the symptoms of the varicosity by reducing the engorgements of the superficial leg veins and also improve the venous valvular functioning and thus helps to push the blood normally without regurgitation.
{"title":"Management of Varicose Vein by Hirudotherapy","authors":"A. Iqbal, H. Quraishi, Huma, A. Shah, Adil Rashid, Abdur Raheem","doi":"10.26438/ijsrbs/v6i2.4349","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.4349","url":null,"abstract":"Received: 26/Mar/2019, Accepted: 13/Apr/2019, Online: 30/Apr/2019 Abstract— Varicose veins are veins that have become enlarged and twisted and are commonly found in legs. The calf muscles of the leg pumps. The venous blood back to the heart against the gravity. When the veins become varicose the valves do not function properly as the blood flows backwards and the veins engorge. The varicose veins are most common in the superficial veins of legs and due to high pressure while standing the veins engorging and ulceration can occur. Only ten percent of the venous blood in the legs is returned back by superficial veins, hence the surgical removal can be opted for superficial varicose veins. Other modalities of treatment included sclerotherapy, elastic stockings, leg elevation, exercise, radiofrequency ablation, endovascular laser treatment etc. In this study Hirudotherapy has been done at Regional Research Institute of Unani Medicine, Srinagar for the treatment of varicose vein and has been observed that leech relieves the symptoms of the varicosity by reducing the engorgements of the superficial leg veins and also improve the venous valvular functioning and thus helps to push the blood normally without regurgitation.","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82131024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.148150
A. Suryawanshi
Received: 20/Mar/2019, Accepted: 11/Apr/2019, Online: 30/Apr/2019 Abstract-Study showed that primary productivity status from site A maximum NPP was found in May (1.7 mg/L/hr), minimum in December (0.08 mg/L/hr) and average NPP value was 0.50 mg/L/hr. GPP was maximum in (2.3 mg/L/hr) in May and minimum in January (0.2 mg/L/hr) average GPP value was 0.97 mg/L/hr. CR was maximum in December (1.4 mg/L/hr) and minimum in (0.2 mg/L/hr) in January. Average CR value was 0.55 mg/L/hr in the year Jan 2013Dec 2013. From site B Maximum NPP value was recorded in May (3.45 mg/L/hr) and minimum in December (0.06 mg/L/hr), average NPP value was 0.45 mg/L/hr. GPP was maximum in May (2.03 mg/L/hr) and minimum in September and November (0.2 mg/L/hr). Average GPP value was 0.86 mg/L/hr. CR was maximum in August (1.7mg/L/hr) and minimum in December (-0.20 mg/L/hr). During the study period average CR value was 0.30 mg/L/hr.
{"title":"Sesoanal Veriation in Primary Productivity from Nanded Region, Maharashtra","authors":"A. Suryawanshi","doi":"10.26438/ijsrbs/v6i2.148150","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.148150","url":null,"abstract":"Received: 20/Mar/2019, Accepted: 11/Apr/2019, Online: 30/Apr/2019 Abstract-Study showed that primary productivity status from site A maximum NPP was found in May (1.7 mg/L/hr), minimum in December (0.08 mg/L/hr) and average NPP value was 0.50 mg/L/hr. GPP was maximum in (2.3 mg/L/hr) in May and minimum in January (0.2 mg/L/hr) average GPP value was 0.97 mg/L/hr. CR was maximum in December (1.4 mg/L/hr) and minimum in (0.2 mg/L/hr) in January. Average CR value was 0.55 mg/L/hr in the year Jan 2013Dec 2013. From site B Maximum NPP value was recorded in May (3.45 mg/L/hr) and minimum in December (0.06 mg/L/hr), average NPP value was 0.45 mg/L/hr. GPP was maximum in May (2.03 mg/L/hr) and minimum in September and November (0.2 mg/L/hr). Average GPP value was 0.86 mg/L/hr. CR was maximum in August (1.7mg/L/hr) and minimum in December (-0.20 mg/L/hr). During the study period average CR value was 0.30 mg/L/hr.","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85717037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.126132
T. M. Manjima, O. G. Indusree, V. Ajitha
— Boerhavia diffusa , commonly known as „Punarnava‟ in the Indian system of medicine is a perennial creeping herb found throughout the waste lands. The insecticidal activity of aqueous and acetone extracts of B. diffusa was tested against the pest insect Dysdercus cingulatus , commonly known as Red Cotton Bug. The plant extract exhibited ovicidal effect, nymphicidal effect, varying degree of moulting disruption, reduced fecundity rate along with prolonged mating period. Insecticidal property exhibited by this plant extract can be exploited in the field of Integrated Pest Management, so as to reduce the hazardous effects of chemical pesticides. The toxic principles present in the plant extract are actually secondary metabolites that are evolved as a protective measure against herbivorous animals. Antimicrobial activity of B. diffusa was also evaluated using gram negative bacteria, Pseudomonas aeruginosa and showed significant level of sensitivity to B. diffusa extracts. Thus it is evident that B. diffusa possess toxic principles having insecticidal as well as antimicrobial activity which can be employed in the field of agriculture and medicine respectively
{"title":"Evaluation of Insecticidal and Antimicrobial Effect of Boerhavia diffusa","authors":"T. M. Manjima, O. G. Indusree, V. Ajitha","doi":"10.26438/ijsrbs/v6i2.126132","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.126132","url":null,"abstract":"— Boerhavia diffusa , commonly known as „Punarnava‟ in the Indian system of medicine is a perennial creeping herb found throughout the waste lands. The insecticidal activity of aqueous and acetone extracts of B. diffusa was tested against the pest insect Dysdercus cingulatus , commonly known as Red Cotton Bug. The plant extract exhibited ovicidal effect, nymphicidal effect, varying degree of moulting disruption, reduced fecundity rate along with prolonged mating period. Insecticidal property exhibited by this plant extract can be exploited in the field of Integrated Pest Management, so as to reduce the hazardous effects of chemical pesticides. The toxic principles present in the plant extract are actually secondary metabolites that are evolved as a protective measure against herbivorous animals. Antimicrobial activity of B. diffusa was also evaluated using gram negative bacteria, Pseudomonas aeruginosa and showed significant level of sensitivity to B. diffusa extracts. Thus it is evident that B. diffusa possess toxic principles having insecticidal as well as antimicrobial activity which can be employed in the field of agriculture and medicine respectively","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"148 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77935024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screening of Ethnic Indian Fermented Foods for Effective Phytase Producing Lactic Acid Bacteria for Application in Dephytinization of Phytate Rich Foods","authors":"N. Sharma, K. Kondepudi, N. Gupta","doi":"10.26438/ijsrbs/v6i2.17","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.17","url":null,"abstract":"","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81262062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.144147
P. Arun, Yaralagadda Vineetha, Maseera Waheed, K. Ravikanth
The main focus of this study is to quantify the amount of lemon juice and apple cider vinegar required to inhibit the growth of lipophilic fungus, Malassezia furfur. Malassezia furfur infects the human scalp, affects hair and causes the dandruff. In this work, the antifungal effect of lemon and apple cider vinegar was investigated along with commercially available antifungal drug fluconazole. Agar diffusion method was used and the zone of inhibition was measured to quantify the amount required and also to estimate the antifungal efficacy of lemon juice and apple cider vinegar. We have used different concentration of lemon juice and apple cider vinegar such as 10%, 20%, 30%, 40%, and 50% concentrations. From our results, by observing the zones of inhibitions on the petridishes, we confirm that lemon juice and apple cider vinegar has good antifungal effect on Malassezia furfur and around 3ml to 4ml of lemon juice or apple cider vinegar diluted and made to 10ml of the solution with water would be sufficient enough to inhibit the growth of Malassezia furfur. This study justifies the use of either lemon juice or apple cider vinegar as a remedy for Malassezia furfur infected scalp and hair. Keywords— Malasezzia furfur, lemon juice, apple cider vinegar, antifungal activity
{"title":"Quantification of the minimum amount of lemon juice and apple cider vinegar required for the growth inhibition of dandruff causing fungi Malassezia furfur","authors":"P. Arun, Yaralagadda Vineetha, Maseera Waheed, K. Ravikanth","doi":"10.26438/ijsrbs/v6i2.144147","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.144147","url":null,"abstract":"The main focus of this study is to quantify the amount of lemon juice and apple cider vinegar required to inhibit the growth of lipophilic fungus, Malassezia furfur. Malassezia furfur infects the human scalp, affects hair and causes the dandruff. In this work, the antifungal effect of lemon and apple cider vinegar was investigated along with commercially available antifungal drug fluconazole. Agar diffusion method was used and the zone of inhibition was measured to quantify the amount required and also to estimate the antifungal efficacy of lemon juice and apple cider vinegar. We have used different concentration of lemon juice and apple cider vinegar such as 10%, 20%, 30%, 40%, and 50% concentrations. From our results, by observing the zones of inhibitions on the petridishes, we confirm that lemon juice and apple cider vinegar has good antifungal effect on Malassezia furfur and around 3ml to 4ml of lemon juice or apple cider vinegar diluted and made to 10ml of the solution with water would be sufficient enough to inhibit the growth of Malassezia furfur. This study justifies the use of either lemon juice or apple cider vinegar as a remedy for Malassezia furfur infected scalp and hair. Keywords— Malasezzia furfur, lemon juice, apple cider vinegar, antifungal activity","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79488637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-30DOI: 10.26438/ijsrbs/v6i2.151155
A. Pal, Astha A. Jain
{"title":"Microbial analysis of water bodies near food industries","authors":"A. Pal, Astha A. Jain","doi":"10.26438/ijsrbs/v6i2.151155","DOIUrl":"https://doi.org/10.26438/ijsrbs/v6i2.151155","url":null,"abstract":"","PeriodicalId":14378,"journal":{"name":"International Journal of Scientific Research in Biological Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81467117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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