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Drain Site Abdominal Hernia: Known but Rare Complication of Abdominal Drains, a Case Report and a Review of Drain Site Complications 引流处疝:已知但罕见的腹腔引流并发症,1例报告及引流处并发症回顾
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704011014
Drains are being used in abdominal surgery since Hippocrates time therapeutically and prohpylactically aiming to reduce morbidity and early recovery of patients. But these drains are not without complications. The complications range from simple drain site infection to drain site hernia of bowel leading to strangulation and necrosis. We report a case of drain site hernia (DSH) in a 47 year-old women who presented with obstructed large incisional hernia through a previous laparotomy scar. During surgery for the incisional hernia an incarcerated DSH was identified at her right iliac fossa region. Both herniae were repaired successfully and patient’s recovery was uneventful. We reviewed the literature regarding the drain site hernia and other complications of abdominal drains. The article describes types of drains, their complications and predisposing factors for those complications and the steps to be taken for the prevention.
从希波克拉底时代开始,引流管就被用于腹部手术,用于治疗和预防,目的是减少发病率和患者的早期康复。但这些排水管并非没有并发症。并发症从单纯的引流处感染到引流处疝导致肠绞窄和坏死。我们报告一例引流部位疝(DSH)在一个47岁的妇女谁提出了阻塞大切口疝通过以前的剖腹手术疤痕。在手术治疗切口疝时,在她的右髂窝区发现了嵌顿性DSH。两疝均成功修复,患者康复顺利。我们回顾了有关引流管部位疝和其他腹部引流管并发症的文献。本文介绍了引流管的类型、并发症、并发症的诱发因素以及预防措施。
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引用次数: 5
Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review 药用植物具有抗氧化和清除自由基的作用(第三部分)-综述
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704014862
Antioxidants are substances that remove, prevent or delay oxidative damage to a target molecule. Therefore, an antioxidant may act to control the level of free radicals to counteract oxidative damage. The effects of medicinal plants in prevention and treatment of many diseases have been widely attributed to their antioxidants activities. This review was designed to highlight the antioxidant effects and free radical scavenging activity of medicinal plants as a third part of our previous reviews.
抗氧化剂是一种可以去除、防止或延缓氧化损伤目标分子的物质。因此,抗氧化剂可以控制自由基的水平,以抵消氧化损伤。药用植物在预防和治疗许多疾病方面的作用已被广泛地归因于其抗氧化活性。这篇综述旨在强调药用植物的抗氧化作用和自由基清除活性,作为我们之前综述的第三部分。
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引用次数: 25
Evaluation of Aframomum melegueta aqueous seed extract on food and water consumption in albino rats 白化大鼠食性及饮水影响评价
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704012326
This experiment was carried out to evaluate the effect of seed extract of Aframomum melegueta on water and feed intake in albino rats. The aqueous seed extract of Aframomum melegueta was administered (p.o) to the animals for 28 days and water and food given 7hrs daily. The animals were divided into four groups of six rats both of the males and females comprising of control groups, 200, 400 and 600mg/kg extract. There was a gradual increase in food intake which affected their body weights dose dependently. Water consumption by all the treated groups from both male and female increased significantly (P≤0.05) when compared with the control groups. The reason could be that there was alteration in the hypothalamus which is a centre that controls appetite and thirst. Conclusively, it induced Polydypsia which represents a compensatory mechanism that maintains total body fluids within normal limits and therefore could be used safely for the management of diseases.
本试验旨在研究金针菇种子提取物对白化大鼠饮水和采食量的影响。给动物水提液(p.o) 28 d,每天给水和食物7h。将实验动物分为4组,每组6只,雄性和雌性均为对照组,分别给予200、400和600mg/kg提取物。食物摄入量的逐渐增加对体重的影响呈剂量依赖性。各处理组雄性和雌性的耗水量均显著高于对照组(P≤0.05)。原因可能是下丘脑发生了变化,下丘脑是控制食欲和口渴的中心。最后,它诱导了多食,这代表了一种代偿机制,将体液总量维持在正常范围内,因此可以安全地用于疾病的管理。
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引用次数: 0
Anticancer effects of Arabian medicinal plants (part 1) - A review 阿拉伯药用植物的抗癌作用(第一部分)——综述
Pub Date : 2017-04-01 DOI: 10.9790/3013-070401634102
Many Arabian medicinal plants possessed anticancer activitys by many mechanisms as tested by different anticancer tests. These plants included: Adonis aestivalis, Ailanthus altissima, Alhagi maurorum, Allium cepa, Allium sativum, Allium schoenoprasum, Althaea officinalis, Althaea rosea, Ammannia baccifera, Anagyris foetida, Anchusa italica, Antirrhinum majus, Apium graveolens, Arctium Lappa, Aristolochia maurorum, Artemisia campestris, Arundo donax, Asclepias curassavica, Asparagus officinalis, Astragalus hamosus, Bauhinia variegata, Bellis perennis, Betula alba, Bidens tripartita, Brassica rapa, Bryonia dioica, Bryophyllum calycinum, Caccinia crassifolia, Caesalpinia crista, Calendula officinalis, Calotropis procera, Canna indica, Capparis spinosa, Capsella bursa-pastoris, Capsicum annuum , Capsicum frutescens, Carthamus tinctorius, Casuarina equisetifolia, Celosia cristata, Chenopodium album, Chrozophora tinctoria, Cicer arietinum, Cichorium intybus, Citrullus colocynthis, Citrus species, Clerodendron inerme, Clitoria ternatea, Convolvulus arvensis, Convolvulus scammonia, Corchorus aestuans, Corchorus capsularis, Coriandrum sativum, Coronilla scorpioides, Coronilla varia, Cotoneaster racemiflora, Crocus sativus, Cuminum cyminum, Cupressus sempervirens, Cuscuta planiflora, Cydonia oblonga, Cynodon dactylon, Cyperus rotuntdus, Dactyloctenium aegyptium, Datura metel , Daucus carota, Delphinium brunonianum, Desmostachya bipinnata, Dianthus caryophyllus, Digitalis lanata , Digitalis purpurea, Dodonaea viscosa, Lablab purpureus, Echinochloa crus-galli, Equisetum arvense, Erigeron canadensis, Erodium cicutarium, Eryngium creticum, Eucalyptus species, Eupatorium cannabinum, Euphorbia hirta, Euphorbia macroclada, Fagopyrum esculentum, Ficus carica , Ficus cunia and Ficus religiosa. The current paper will discuss the anticancer effects of some medicinal plants as a first part of this review.
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引用次数: 23
A Study of Cutaneous Adverse Drug Reactions in A Tertiary Care Teaching Hospital 某三级教学医院皮肤药物不良反应的调查研究
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704011822
Adverse drug reactions (ADR’s) are the major cause of morbidity and mortality and most of the adverse drug reactions become evident only when the drug enters into the market, as clinical trials conducted on drugs involve only a limited number of subjects. Cutaneous manifestations of ADR’s occur more frequently, hence this study was conducted to detect the morphological pattern, the common drugs causing cutaneous ADR’s and to assess the severity of the same using Naranjo’s algorithm. This was a prospective study conducted over a period of one year in the department of Dermatology and the department of Pharmacology. All the ADR’s reported during the study period were confirmed by a dermatologist and assessed using Naranjo’s algorithm. A total of 90 Cutaneous Adverse Drug Reactions (CADR’s) were reported during the study period. Fixed drug eruption was the most common morphological pattern of ADR. Antibiotics were the most common drugs involved in causing CADR’s. Most of the CADR’s belonged to Probable category. Hence this study showed that CADR’s are common to the drugs widely used, and the detection of the same will enable the treating physician to withdraw the use of the suspected drug. Also spontaneous reporting of ADR’s will strengthen the Indian Pharmacovigilance database.
药物不良反应(ADR’s)是发病率和死亡率的主要原因,由于药物临床试验涉及的受试者数量有限,大多数药物不良反应只有在药物进入市场时才会显现出来。由于ADR的皮肤表现较为常见,因此本研究旨在检测皮肤ADR的形态形态、常见药物引起的ADR,并采用Naranjo算法评估ADR的严重程度。这是一项为期一年的前瞻性研究在皮肤科和药学系进行。研究期间报告的所有不良反应均由皮肤科医生确认,并使用Naranjo算法进行评估。在研究期间共报告了90例皮肤药物不良反应(CADR)。固定药疹是ADR最常见的形态类型。抗生素是引起CADR最常见的药物。大多数CADR属于可能类别。因此,本研究表明,在广泛使用的药物中,CADR是常见的,检测到CADR可以使治疗医生停止使用可疑药物。此外,自发报告不良反应将加强印度药物警戒数据库。
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引用次数: 6
Comparison of the Matching of Keywords of Abstracts of Articles Latin Selected Journals of Iranian Dental Indexed in Pubmed with Medical Subject Headings (MeSH) Pubmed医学主题目(MeSH)检索伊朗牙科拉丁精选期刊文章摘要关键词匹配比较
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704014347
Background: This study evaluates the quality of keywords of abstracts of Latin Selected Journals of Iranian Dental indexed in PubMed with Medical Subject Headings (MeSH). Materials and Methods: The study is comparative descriptive. The data gathering tool is a researcher-made checklist. The Statistical population of the study is two Latin Journals of Iranian Dental approved by the Ministry of Health that indexed in PubMed. The Access 2013 software was used to describe data. Results: In total, 866 keywords of 208 articles were studied. On average, 4.2 keywords were in per article of selected Journals. The amount of the Exact match, Relatively match and Not match keywords in selected Journals is 39.5%, 35.8% and 24.8% respectively. More keywords of articles of both selected journals are the type of partial match with MeSH Headings or Entry Terms, and then keywords that are consistent with Entry Terms. Conclusions: Despite the higher rate of consistent keywords of articles of the journal "J Dent (Tehran)" to the journal "Dent Res J (Isfahan)", the precision in the use of MeSH in both of the selected journal was not at a desirable level and the authors of the selected journals must have more attention in selecting their words index based on MeSH.
背景:本研究评估了在PubMed与医学主题标题(MeSH)中检索的伊朗牙科拉丁精选期刊摘要的关键词质量。材料与方法:采用比较描述性研究。数据收集工具是研究人员制作的清单。该研究的统计对象是卫生部批准的两本在PubMed索引的伊朗牙科拉丁文期刊。使用Access 2013软件对数据进行描述。结果:共研究了208篇文章的866个关键词。入选期刊平均每篇文章包含4.2个关键词。“完全匹配”、“相对匹配”和“不匹配”关键词在入选期刊中的占比分别为39.5%、35.8%和24.8%。所选期刊文章的关键词更多是与MeSH heading或Entry Terms部分匹配的类型,然后是与Entry Terms一致的类型。结论:尽管“J Dent (Tehran)”期刊的文章与“Dent Res J (Isfahan)”期刊的关键词一致性率较高,但两种期刊在使用MeSH时的精度都不理想,入选期刊的作者在选择基于MeSH的词语索引时必须更加注意。
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引用次数: 2
Medicinal plants for prevention and treatment of cardiovascular diseases - A review 预防和治疗心血管疾病的药用植物综述
Pub Date : 2017-04-01 DOI: 10.9790/3013-070401103163
There were substantial evidences that many medicinal plants decreased the risk of cardiovascular diseases. With the high prevalence of herbal medicine use worldwide, the information regarding the therapeutic use or safety of herbal remedies usually obtained from books and pamphlets, most of which base their information on traditional reputation rather than relying on existing scientific research. This review will cover the plants with vascular, hypotensive, cardiac, cardioprotective, antiarrhythmic, hypolipidemic, hemostatic, fibrinolytic and anticoagulant effects.
有大量证据表明,许多药用植物可以降低心血管疾病的风险。随着世界范围内草药使用的高度普及,关于草药治疗用途或安全性的信息通常从书籍和小册子中获得,其中大部分信息基于传统声誉,而不是依靠现有的科学研究。本文综述了具有血管、降血压、心脏、心脏保护、抗心律失常、降血脂、止血、溶纤维蛋白和抗凝作用的植物。
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引用次数: 18
Quantitative Structure antifungal Activity Relationship (QSAR) study of a series of Schiff bases derivatives from4- aminobenzenesulphonamide by DFT method 用DFT方法研究4-氨基苯磺酰胺席夫碱衍生物的定量结构抗真菌活性关系
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704012733
1 N’dri Jean Stéphane, 1 Koné M. Guy-Richard, 1,2* Kodjo Charles Guillaume, 1 Affi Sopi Thomas, 3 Kablan Ahmont Landry Claude, 2 Ouattara Zana Adama and 1 Ziao Nahossé 1 Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Université Nangui Abrogoua 02 BP 801 Abidjan 02, Côte-d’Ivoire, 2 Laboratoire de Chimie BioOrganique et de Substances Naturelles, Université Nangui Abrogoua, UFR-SFA, 02 B.P. 801 Abidjan 02 Côte-d’Ivoire, 3 UFR des Sciences Biologiques, Université Péléforo Gon Coulibaly de Korhogo, BP 1328 Korhogo, Côte d’Ivoire ABSTRACT : In this work we will focus on a series of Schiff bases derived from 4aminobenzenesulphonamide. By implementing quantum chemistry methods, at B3LYP/6-311 G (d, p) level, we have identified two QSAR models from quantum descriptors and antifungal activities against Candida albicans and Aspergillus niger strains that were accredited of good statistical performance. For model 1 statistical indicators were: correlation coefficient R 2 = 0.984, standard deviation S=0.514 , Fischer test F=90.753 and the correlation coefficient of cross-validation QCV 2 = 0.983. Wereas the statistical datas of model 2 were: correlation coefficient R 2 =0.952, standard deviation S=0.596, Fischer test F=79.022 and the correlation coefficient of crossvalidation QCV 2 = 0.951. These two models showed that quantum descriptors namely dipole moment and index of electrophilie were the bases for antifungal activity of these Schiff bases. These models were validated with the criteria of acceptance Eriksson et al. for training set and Tropsha et al. for the validation set.
1 N 'dri Jean st, 1 kon M. Guy-Richard, 1,2* Kodjo Charles Guillaume, 1 Affi Sopi Thomas, 3 Kablan Ahmont Landry Claude, 2 Ouattara Zana Adama和1 Ziao nahossss1热力学和物理化学实验室,UFR SFA, Nangui Abrogoua大学02 BP 801阿比让02,Côte-d '科特迪瓦,2生物有机化学和自然物质实验室,UFR SFA, 02 B.P. 801阿比让02 Côte-d '科特迪瓦,3 UFR生物科学,摘要:本研究将重点研究从4氨基苯磺酰胺中衍生的一系列希夫碱。通过量子化学方法,在B3LYP/6-311 G (d, p)水平上,我们从量子描述符和对白色念珠菌和黑曲霉菌株的抗真菌活性中确定了两个QSAR模型,并获得了良好的统计性能。模型1的统计指标为:相关系数r2 = 0.984,标准差S=0.514, Fischer检验F=90.753,交叉验证相关系数QCV 2 = 0.983。模型2的统计数据为:相关系数r2 =0.952,标准差S=0.596, Fischer检验F=79.022,交叉验证相关系数QCV 2 = 0.951。这两个模型表明,量子描述子即偶极矩和亲电性指数是这些席夫碱抗真菌活性的基础。使用Eriksson等人的训练集和Tropsha等人的验证集的接受标准对这些模型进行验证。
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引用次数: 4
Physiological effect of Natural Penicillin Extract on Cassava Peel Media by Penicillium chrysogenum PCL501 on E.coli Infected Wistar Rats 木薯皮青霉PCL501培养基中天然青霉素提取物对大肠杆菌感染Wistar大鼠的生理影响
Pub Date : 2017-04-01 DOI: 10.9790/3013-0704013442
Some physiological effect of natural penicillin extract produced on cassava peel media by Penicillium chrysogenum PCL501 on E.coli infected Wistar rats were evaluated. Fermentation of P. chrysogenum PCL501 with cassava peels – an agro-wasteproduced natural antibiotics. In vitro antibiotic activity of cassava peels culture extract was tested against two clinical bacterial isolates, namely, Bacillus subtilis, and Escherichia coli. The culture extract and standard drug (commercial Benzyl Penicillin) inhibited the growth B. subtilis and E. coli. Antibiotic activity of the culture extract was comparable with that of the standard drug. In vivo antibiotic action on Wistar Wistar rats infected with E. coli showed that the penicillin produced on cassava peel was potent as its administration leads to the recovery of the infected animals. Evaluation of biochemical indices of E. coli infected Wistar rats and treatment with extract confirms that the extract is a potent antibiotic. The haematological evaluation showed a significant decrease (p<0.05) in platelet count in animals administered with both the extract and reference drug. Cassava peels are indicated as a suitable and cheap carbon source for the production of penicillin by P. chrysogenum PCL501.
研究了由青霉菌PCL501在木薯皮培养基上制备的天然青霉素提取物对大肠杆菌感染Wistar大鼠的生理作用。用木薯皮——一种农业废料产生的天然抗生素——发酵P. chrygenum PCL501。研究了木薯皮培养液对枯草芽孢杆菌和大肠杆菌两种临床分离菌的体外抗菌活性。培养提取物和标准药物(市售苄青霉素)抑制枯草芽孢杆菌和大肠杆菌的生长。培养提取物的抗菌活性与标准药物相当。对感染大肠杆菌的Wistar Wistar大鼠的体内抗生素作用表明,木薯皮产生的青霉素是有效的,因为它的施用导致感染动物的恢复。大肠杆菌感染Wistar大鼠的生化指标评价及提取物处理证实了该提取物是一种有效的抗生素。血液学评价显示,同时给予提取物和对照药物的动物血小板计数显著降低(p<0.05)。木薯皮被认为是一种合适的廉价碳源,可用于利用P. chrysogenum PCL501生产青霉素。
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引用次数: 1
Chemical contents and medical importance of Dianthus caryophyllus- A review 石竹化学成分及其药用价值综述
Pub Date : 2017-03-01 DOI: 10.9790/3013-0703016171
{"title":"Chemical contents and medical importance of Dianthus caryophyllus- A review","authors":"A. Al-Snafi","doi":"10.9790/3013-0703016171","DOIUrl":"https://doi.org/10.9790/3013-0703016171","url":null,"abstract":"","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"162 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91018311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
期刊
IOSR Journal of Pharmacy
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