M. Getia, V. Mshvildadze, A. Pichette, G. Dekanosidze, Z. Kemoklidze
“Fatsiflogin” is an original, nonsteroidal para-medical preparation from the leaves of Fatsia japonica with anti-rheumatic, anti-inflammatory and analgesic activities. Fatsioside D (tetraosid of hederagenin) as one of the major compound of “Fatsiflogin”, was selected as a chemical markerfor the quantitative validation. The objective of this study is to develop a simple and reliable HPLC method for the determination of Fatsiosid D for quality control studies of “Fatsiflogin”. FatsiosideD was purified by preparative HPLC and the structure of the compound was determined by NMR. HPLC separation was performed on an intertsil prep-ODS C18 column, with a solvent system water-acetonitrile. The UV detection is performed at 205 nm. The proposed HPLC method is linear in the range studied (r 2 > 0.999) for all the analytes. The method is precise with intraand inter-day variations of less than 3.34%. The mean recoveries of the analytes range from 99.68 to 100.29%. The method is successfully applied to the quantification of Fatsioside D. The results indicated that developed HPLC method could be used for the quality control of “Fatsiflogin”.
“Fatsiflogin”是一种原始的，非甾体类药物制剂，从日本Fatsia的叶子中提取，具有抗风湿，抗炎和镇痛活性。选择fatsisidside D (hederagenin的tetraosid of hederagenin)作为“Fatsiflogin”的主要化合物之一作为化学标记进行定量验证。本研究的目的是建立一种简便、可靠的高效液相色谱法测定Fatsiosid D含量的方法，用于“Fatsiflogin”的质量控制研究。采用制备高效液相色谱法对化合物进行了纯化，并用核磁共振法对化合物结构进行了表征。色谱柱为intertsil prep-ODS C18，溶剂体系为水-乙腈。紫外检测在205 nm处进行。所建立的高效液相色谱法在研究范围内呈线性关系(r = 2 ~ 0 0.999)。方法精度高，日内、日间变化小于3.34%。分析物的平均回收率为99.68 ~ 100.29%。该方法成功地应用于脂苷d的定量分析，结果表明所建立的高效液相色谱法可用于脂苷d的质量控制。
{"title":"Development of Analytical Procedure for the Quantification of “Fatsiflogin”","authors":"M. Getia, V. Mshvildadze, A. Pichette, G. Dekanosidze, Z. Kemoklidze","doi":"10.9790/3013-0703019699","DOIUrl":"https://doi.org/10.9790/3013-0703019699","url":null,"abstract":"“Fatsiflogin” is an original, nonsteroidal para-medical preparation from the leaves of Fatsia japonica with anti-rheumatic, anti-inflammatory and analgesic activities. Fatsioside D (tetraosid of hederagenin) as one of the major compound of “Fatsiflogin”, was selected as a chemical markerfor the quantitative validation. The objective of this study is to develop a simple and reliable HPLC method for the determination of Fatsiosid D for quality control studies of “Fatsiflogin”. FatsiosideD was purified by preparative HPLC and the structure of the compound was determined by NMR. HPLC separation was performed on an intertsil prep-ODS C18 column, with a solvent system water-acetonitrile. The UV detection is performed at 205 nm. The proposed HPLC method is linear in the range studied (r 2 > 0.999) for all the analytes. The method is precise with intraand inter-day variations of less than 3.34%. The mean recoveries of the analytes range from 99.68 to 100.29%. The method is successfully applied to the quantification of Fatsioside D. The results indicated that developed HPLC method could be used for the quality control of “Fatsiflogin”.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"75 1","pages":"96-99"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86338869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shetty, N. Vinutha, Sagar F. Udasimath, Kalleshappa C.M., Krupanidhi A.M., A. Akshara
{"title":"Evaluation Of Skeletal Muscle Relaxant Activity Of Ethanol Extract Of Chromoleana Odorata","authors":"A. Shetty, N. Vinutha, Sagar F. Udasimath, Kalleshappa C.M., Krupanidhi A.M., A. Akshara","doi":"10.9790/3013-0703019295","DOIUrl":"https://doi.org/10.9790/3013-0703019295","url":null,"abstract":"","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"7 1","pages":"92-95"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79494681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fagopyrum esculentum contained alkaloids, amino acids, anthraquinones, carbohydrates, flavonoids, phlobatannins and tannins. The nutritional analysis of Fagopyrum esculentum flour and bran revealed that they contained starch: 55, 75 and 18%; proteins: 12, 6 and 36%; lipids: 4, 1 and 11%; soluble carbohydrates: 2, 1 and 6%; total dietary fibers: 7, 3 and 15%; and ash: 2, 1 and 7% respectively. The pharmacological studies showed that Fagopyrum esculentum possessed antioxidant, antiinflammatory, cardiovascular, hypolipidemic, antigenotoxic, antidiabetic, reno-protective, anticancer, antimicrobial, wound healing, antistress, protected memory impairment and photoprotective effects. This review will highligh the chemical constituents and pharmacological effects of Fagopyrum esculentum.
{"title":"A review on Fagopyrum esculentum: A potential medicinal plant","authors":"A. Al-Snafi","doi":"10.9790/3013-0703012132","DOIUrl":"https://doi.org/10.9790/3013-0703012132","url":null,"abstract":"Fagopyrum esculentum contained alkaloids, amino acids, anthraquinones, carbohydrates, flavonoids, phlobatannins and tannins. The nutritional analysis of Fagopyrum esculentum flour and bran revealed that they contained starch: 55, 75 and 18%; proteins: 12, 6 and 36%; lipids: 4, 1 and 11%; soluble carbohydrates: 2, 1 and 6%; total dietary fibers: 7, 3 and 15%; and ash: 2, 1 and 7% respectively. The pharmacological studies showed that Fagopyrum esculentum possessed antioxidant, antiinflammatory, cardiovascular, hypolipidemic, antigenotoxic, antidiabetic, reno-protective, anticancer, antimicrobial, wound healing, antistress, protected memory impairment and photoprotective effects. This review will highligh the chemical constituents and pharmacological effects of Fagopyrum esculentum.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"21 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73432262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus torquata and Eucalyptus microtheca (Syn: Eucalyptus coolabahs). Eucalypts contained volatile oils which occurred in many parts of the plant, depending on the species, but in the leaves that oils were most plentiful. The main constituent of the volatile oil derived from fresh leaves of Eucalyptus species was 1,8-cineole. The reported content of 1,8-cineole varies for 54-95%. The most common constituents co-occurring with 1,8cineole were limonene, α-terpineol, monoterpenes, sesquiterpenes, globulol and α , β and Υ-eudesmol, and aromatic constituents. The pharmacological studies revealed that Eucalypts possessed gastrointestinal, antiinflammatory, analgesic, antidiabetic, antioxidant, anticancer, antimicrobial, antiparasitic, insecticidal, repellent, oral and dental, dermatological, nasal and many other effects. The current review highlights the chemical constituents and pharmacological and therapeutic activities of Eucalyptus species grown in Iraq.
{"title":"The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq","authors":"A. Al-Snafi","doi":"10.9790/3013-0703017291","DOIUrl":"https://doi.org/10.9790/3013-0703017291","url":null,"abstract":"Eucalyptus species grown in Iraq were included Eucalyptus bicolor (Syn: Eucalyptus largiflorens), Eucalyptus griffithsii, Eucalyptus camaldulensis (Syn: Eucalyptus rostrata) Eucalyptus incrassate, Eucalyptus torquata and Eucalyptus microtheca (Syn: Eucalyptus coolabahs). Eucalypts contained volatile oils which occurred in many parts of the plant, depending on the species, but in the leaves that oils were most plentiful. The main constituent of the volatile oil derived from fresh leaves of Eucalyptus species was 1,8-cineole. The reported content of 1,8-cineole varies for 54-95%. The most common constituents co-occurring with 1,8cineole were limonene, α-terpineol, monoterpenes, sesquiterpenes, globulol and α , β and Υ-eudesmol, and aromatic constituents. The pharmacological studies revealed that Eucalypts possessed gastrointestinal, antiinflammatory, analgesic, antidiabetic, antioxidant, anticancer, antimicrobial, antiparasitic, insecticidal, repellent, oral and dental, dermatological, nasal and many other effects. The current review highlights the chemical constituents and pharmacological and therapeutic activities of Eucalyptus species grown in Iraq.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"71 1","pages":"72-91"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75060488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tchabong Tchabong, Jazet, Sameza D.P.M., T. M.L., N. S. Mounbain, F. Mouelle, Menut S.A., F. Tchoumbougnang
Background: These investigations were carried out to analyze the chemical composition, to evaluate the radical scavenging, and the anti-fungal activities of essential oils from leaves and fruits of Zanthoxylumleprieurii. Methods: Oils were obtained by hydro distillation using Clevenger-type apparatus. The compounds were identified by gas chromatography and gas chromatography coupled with Mass Spectrometry. Antifungal activity of the essential oils was tested in vitro against Epidermophytonfloccosum and Trichophytonrubrumwhile free radical scavenging activity evaluation was done using 2,2-diphenyl picrylhydrazyl method. Results: Results showed that, the major components of the leaves oil were (E)-ß-ocimene (91.5 %) while the most abundant component from fruits oil were (E)-ß-Ocimene (90.3 %). The total growth inhibition of the pathogens by fruits essential oil occurred at 4.0 mg/ml and 3.0 mg/ml respectively, forEpidermophytonfloccosum and Trichophytonrubrum. The leaves oil exhibited total growth inhibition at 4.0 mg/ml against both pathogens. These oils also showed antioxidant activities with SC50 values at 2.0 mg/ml and 5.0 mg/ml respectively, for fruits and leaves. There were positive and significant correlations between mycelia growth inhibition of both pathogens and the antioxidant activities of the tested oils noted. Conclusion: These results showed that, Z. leprieurii essential oils could be used as a resource of antioxidant and antidermatophitic compounds with may find applications in pharmaceutical industries.
{"title":"Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum","authors":"Tchabong Tchabong, Jazet, Sameza D.P.M., T. M.L., N. S. Mounbain, F. Mouelle, Menut S.A., F. Tchoumbougnang","doi":"10.9790/3013-0703010106","DOIUrl":"https://doi.org/10.9790/3013-0703010106","url":null,"abstract":"Background: These investigations were carried out to analyze the chemical composition, to evaluate the radical scavenging, and the anti-fungal activities of essential oils from leaves and fruits of Zanthoxylumleprieurii. Methods: Oils were obtained by hydro distillation using Clevenger-type apparatus. The compounds were identified by gas chromatography and gas chromatography coupled with Mass Spectrometry. Antifungal activity of the essential oils was tested in vitro against Epidermophytonfloccosum and Trichophytonrubrumwhile free radical scavenging activity evaluation was done using 2,2-diphenyl picrylhydrazyl method. Results: Results showed that, the major components of the leaves oil were (E)-ß-ocimene (91.5 %) while the most abundant component from fruits oil were (E)-ß-Ocimene (90.3 %). The total growth inhibition of the pathogens by fruits essential oil occurred at 4.0 mg/ml and 3.0 mg/ml respectively, forEpidermophytonfloccosum and Trichophytonrubrum. The leaves oil exhibited total growth inhibition at 4.0 mg/ml against both pathogens. These oils also showed antioxidant activities with SC50 values at 2.0 mg/ml and 5.0 mg/ml respectively, for fruits and leaves. There were positive and significant correlations between mycelia growth inhibition of both pathogens and the antioxidant activities of the tested oils noted. Conclusion: These results showed that, Z. leprieurii essential oils could be used as a resource of antioxidant and antidermatophitic compounds with may find applications in pharmaceutical industries.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"42 2 1","pages":"01-06"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86805829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)- A review","authors":"A. Al-Snafi","doi":"10.9790/3013-0703010720","DOIUrl":"https://doi.org/10.9790/3013-0703010720","url":null,"abstract":"-The phytochemical screening of Euphorbia hirta revealed that the plant contained reducing sugars, terpenoids, alkaloids, steroids, tannins, proteins, fats, oils, gums, mucilages, glycoside, saponin, coumarin, cardiac glycosides, anthroquinones, flavanoids and phenolic compounds. The previous pharmacological studies showed that Euphorbia hirta exerted antioxidant, antimicrobial, sedative anxiolytic, antiepileptic, antiinflammatory, analgesic, antipyretic, antihistaminic, antiasthmatic, antidiabetic, anticancer, wound healing, gastrointestinal, diuretic, antiparasitic, immunological, hepatoprotective, galactogenic, angiotensin converting enzyme inhibiting and anti-dipsogenic activities. The current review discussed the chemical constituents, pharmacological and therapeutic potential of Euphorbia hirta.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"99 1","pages":"07-20"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79266103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
-The effect of an Ayurvedic formulation promoted for treatment of vitiligovisa-visTolenorm ointment in triggering the genetic memory of the skin on exposure to sun was studied using Mexameter. Findings suggest that Tolenorm ointment elicit faster release of melanosomes to keratinocytes and simultaneously protecting the skin from sun damage. Irrespective of the extent of sun exposure,Tolenorm ointment triggers pigmentogenesis within 5 minutes indicating its rapid absorption. Details of the study are presented in the article.
{"title":"Comparative study on anointment promoted for Vitiligo Vis-À- Vis Tolenormointment in causing Immediate Pigment Darkening","authors":"Aruna., R. Priya, S. Mukherjee, G. Rajagopal","doi":"10.9790/3013-0701010103","DOIUrl":"https://doi.org/10.9790/3013-0701010103","url":null,"abstract":"-The effect of an Ayurvedic formulation promoted for treatment of vitiligovisa-visTolenorm ointment in triggering the genetic memory of the skin on exposure to sun was studied using Mexameter. Findings suggest that Tolenorm ointment elicit faster release of melanosomes to keratinocytes and simultaneously protecting the skin from sun damage. Irrespective of the extent of sun exposure,Tolenorm ointment triggers pigmentogenesis within 5 minutes indicating its rapid absorption. Details of the study are presented in the article.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"53 1","pages":"01-03"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90550295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. D. Devi, M. Priyanka, A. Swathi, Jasti.Krishna Sai, Kishore Babu
Hypertension is common in hemodialysis patients and can often be difficult to control. Considering the high cardiovascular burden in hemodialysis patients, control of blood pressure is important to improve outcomes. This study is conducted to assess the anti hypertensive drugs treatment in chronic kidney disease (CKD) patients. This is a prospective observational study and includes information regarding CKD patients with co-morbidities like T2DM and HTN and it is conducted among 15 patients which were of both males and females of above 20 yrs of age upto 80 yrs. For these 15 patients e GFR is calculated and stage of severity of CKD was found. Patients with T2DM and Hypertensive are mostly diagnosed with CKD. Loop diuretic (Furosemide)+ calcium channel blocker (Amlodipine) this combination is prescribed more which is found to be safe for CKD patients as for this combination dosage adjustment is not required. In our study among 15 CKD patients 7 dialysis patients were included, majority of the patients have controlled SBP with the anti- hypertensive combinations. acute myocardial infarction 1-3 . They remain the firstline therapy for patients with cardiovascular (CV) disease. Similarly, in patients with diabetic and non-diabetic kidney disease, several large trials have demonstrated their effectiveness in reducing proteinuria and delaying progression of chronic kidney disease. The major adverse effects associated with ACEI and ARB use are hyperkalemia, decrease in glomerular filtration rate (GFR), and erythropoietin resistance. The risk of hyperkalemia increases with the degree of decrease in GFR in the nondialysis population 4 . The most common pattern of BP in dialysis patients is systolic hypertension associated with a wide pulse pressure due to atherosclerotic arterial stiffness. The main pathogenic mechanisms of hypertension in dialysis patients. Extracellular fluid overload is the most common feature in hypertensive dialysis patients. Indeed, insufficient volume removal is often the major factor responsible for dialysis-refractory hypertension 5-9
{"title":"Assessment of Anti Hypertensive Drugs In Ckd Patients","authors":"N. D. Devi, M. Priyanka, A. Swathi, Jasti.Krishna Sai, Kishore Babu","doi":"10.9790/3013-068021621","DOIUrl":"https://doi.org/10.9790/3013-068021621","url":null,"abstract":"Hypertension is common in hemodialysis patients and can often be difficult to control. Considering the high cardiovascular burden in hemodialysis patients, control of blood pressure is important to improve outcomes. This study is conducted to assess the anti hypertensive drugs treatment in chronic kidney disease (CKD) patients. This is a prospective observational study and includes information regarding CKD patients with co-morbidities like T2DM and HTN and it is conducted among 15 patients which were of both males and females of above 20 yrs of age upto 80 yrs. For these 15 patients e GFR is calculated and stage of severity of CKD was found. Patients with T2DM and Hypertensive are mostly diagnosed with CKD. Loop diuretic (Furosemide)+ calcium channel blocker (Amlodipine) this combination is prescribed more which is found to be safe for CKD patients as for this combination dosage adjustment is not required. In our study among 15 CKD patients 7 dialysis patients were included, majority of the patients have controlled SBP with the anti- hypertensive combinations. acute myocardial infarction 1-3 . They remain the firstline therapy for patients with cardiovascular (CV) disease. Similarly, in patients with diabetic and non-diabetic kidney disease, several large trials have demonstrated their effectiveness in reducing proteinuria and delaying progression of chronic kidney disease. The major adverse effects associated with ACEI and ARB use are hyperkalemia, decrease in glomerular filtration rate (GFR), and erythropoietin resistance. The risk of hyperkalemia increases with the degree of decrease in GFR in the nondialysis population 4 . The most common pattern of BP in dialysis patients is systolic hypertension associated with a wide pulse pressure due to atherosclerotic arterial stiffness. The main pathogenic mechanisms of hypertension in dialysis patients. Extracellular fluid overload is the most common feature in hypertensive dialysis patients. Indeed, insufficient volume removal is often the major factor responsible for dialysis-refractory hypertension 5-9","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"22 3 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79809171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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