M. Amutha, J. Sivasakthi, Dr.A. Gubendran, P. Dhanasekaran, R. Imayatharasi
R.Imayatharasi 2 , 1 Assistant professor, Department of chemistry V.V.Vanniaperumal college for women Virudhunagar, Tamilnadu, India. 1 .M.Sc Scholar Department of chemistry V.V.Vanniaperumal college for women Virudhunagar, Tamilnadu. 2 .Associate professor Department of chemistry Saraswathi Narayanan College, Madurai, Tamilnadu, India. 2 . M.Phil Scholars, Department of chemistry Saraswathi Narayanan College, Madurai, Tamilnadu, India.
{"title":"Studies on Metal Chelating Property and Pharmaceutical Applications of Curcumin Metal Complex.","authors":"M. Amutha, J. Sivasakthi, Dr.A. Gubendran, P. Dhanasekaran, R. Imayatharasi","doi":"10.9790/3008-1203017277","DOIUrl":"https://doi.org/10.9790/3008-1203017277","url":null,"abstract":"R.Imayatharasi 2 , 1 Assistant professor, Department of chemistry V.V.Vanniaperumal college for women Virudhunagar, Tamilnadu, India. 1 .M.Sc Scholar Department of chemistry V.V.Vanniaperumal college for women Virudhunagar, Tamilnadu. 2 .Associate professor Department of chemistry Saraswathi Narayanan College, Madurai, Tamilnadu, India. 2 . M.Phil Scholars, Department of chemistry Saraswathi Narayanan College, Madurai, Tamilnadu, India.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"38 1","pages":"72-77"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80150449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Infectious diseases represent an important cause of morbidity and mortality among the populations, particularly in developing countries. Therefore, pharmaceutical companies have been motivated to develop new antimicrobial drugs in the recent years especially due to the constant emergence of microorganisms resistant to conventional antimicrobials. The current study aims to evaluate the antimicrobial efficacy of some essential oils (EOs) against multidrug resistant (MDR) K. pneumoniae. Antibiotic susceptibility profile of 15 K. pneumoniae isolates was performed against 14 antibiotics and 14 essential oils. The effect of the most potent EO against the chosen isolate regarding some virulence factors and DNA fragmentation was studied. Among all the tested antibacterial agents, MEO was the most effective one. Gas chromatography/mass spectrometry of MEO revealed that, terpinen-4-ol was the major constituent followed by γ-terpinene. Treatment using MEO led to a significant reduction in biofilm formation, complete killing within 4 hours, change in membrane permeability and reduction of capsular layer of the tested cells. Also, 2 MIC of MEO caused the highest damage of bacterial DNA. This study strongly suggests that MEO possesses antibacterial properties and induces DNA degradation. These results were correlated with chemical composition of the tested oil. Key Words; Antimicrobial resistance; Essential oils; Biofilm formation; DNA fragmentationn
{"title":"Impact of Marjoram (Origanum marjorana L.) Essential Oil on Some Virulence Factors and DNA Integrity of Multidrug Resistant Klebsiella pneumoniae","authors":"Y. El-TablawyS., E. Araby","doi":"10.9790/3008-1203016371","DOIUrl":"https://doi.org/10.9790/3008-1203016371","url":null,"abstract":"Infectious diseases represent an important cause of morbidity and mortality among the populations, particularly in developing countries. Therefore, pharmaceutical companies have been motivated to develop new antimicrobial drugs in the recent years especially due to the constant emergence of microorganisms resistant to conventional antimicrobials. The current study aims to evaluate the antimicrobial efficacy of some essential oils (EOs) against multidrug resistant (MDR) K. pneumoniae. Antibiotic susceptibility profile of 15 K. pneumoniae isolates was performed against 14 antibiotics and 14 essential oils. The effect of the most potent EO against the chosen isolate regarding some virulence factors and DNA fragmentation was studied. Among all the tested antibacterial agents, MEO was the most effective one. Gas chromatography/mass spectrometry of MEO revealed that, terpinen-4-ol was the major constituent followed by γ-terpinene. Treatment using MEO led to a significant reduction in biofilm formation, complete killing within 4 hours, change in membrane permeability and reduction of capsular layer of the tested cells. Also, 2 MIC of MEO caused the highest damage of bacterial DNA. This study strongly suggests that MEO possesses antibacterial properties and induces DNA degradation. These results were correlated with chemical composition of the tested oil. Key Words; Antimicrobial resistance; Essential oils; Biofilm formation; DNA fragmentationn","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"52 1","pages":"63-71"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83965544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Keerthana, Vijay Jagadeesh Kakimani, N. Reddy, K. Chandrasekhar, D. Ranganayakulu
Cauda equina syndrome (CES) is a rare syndrome which is characterized by low back pain, unilateral or bilateral sciatica, motor weakness of lower extremities, saddle anesthesia, bowel and bladder dysfunction and occasionally paraplegia—resulting from compression of the cauda equina. It can be caused by herniated disc, tumor, infection, fracture, or narrowing of spinal cord. It can be described in two forms based on the onset of signs and symptoms. if symptoms appear within 24hours then it is acute in onset and if patient develop symptoms after several weeks or months then it is gradual in onset. The sooner it can be diagnosed, the better chance the patient makes a better recovery from symptoms of nerve damage. It generally requires prompt surgical decompression in order to decrease or eliminate pressure on the affected nerves. surgical decompression is advocated as soon as possible, within about 8 hours of the onset of symptoms if symptoms develop suddenly. If patients with cauda equina syndrome do not receive treatment quickly, adverse results can include paralysis, impaired bladder, and/or bowel control, difficulty walking, and/or other neurological and physical problems.
{"title":"Cauda Equina Syndrome: A Case Report","authors":"T. Keerthana, Vijay Jagadeesh Kakimani, N. Reddy, K. Chandrasekhar, D. Ranganayakulu","doi":"10.9790/3008-1203031516","DOIUrl":"https://doi.org/10.9790/3008-1203031516","url":null,"abstract":"Cauda equina syndrome (CES) is a rare syndrome which is characterized by low back pain, unilateral or bilateral sciatica, motor weakness of lower extremities, saddle anesthesia, bowel and bladder dysfunction and occasionally paraplegia—resulting from compression of the cauda equina. It can be caused by herniated disc, tumor, infection, fracture, or narrowing of spinal cord. It can be described in two forms based on the onset of signs and symptoms. if symptoms appear within 24hours then it is acute in onset and if patient develop symptoms after several weeks or months then it is gradual in onset. The sooner it can be diagnosed, the better chance the patient makes a better recovery from symptoms of nerve damage. It generally requires prompt surgical decompression in order to decrease or eliminate pressure on the affected nerves. surgical decompression is advocated as soon as possible, within about 8 hours of the onset of symptoms if symptoms develop suddenly. If patients with cauda equina syndrome do not receive treatment quickly, adverse results can include paralysis, impaired bladder, and/or bowel control, difficulty walking, and/or other neurological and physical problems.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"9 1","pages":"15-16"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82419209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the current study the long-term effect of omeprazole was determined by measuring some hematological parameters .Three groups of laboratory rats were taken each group (6) individual, the first groups was the control, second and third were given the drug with a dose of 20 and 40 respectively for three consecutive months. There are significant effects at (p˃0.05) in all parameters which include white and red blood cells counts(WBC and RBC), Hemoglobin concentration(Hb) and the ratio of neutrophils and lymphocytes in both treated groups(the effect is significant for both doses) compared with control, That is, there was a clear effect of omeprazole on the blood picture.
{"title":"The Effect of Omeprazole Drug on the Blood Picture of Laboratory Rat Rattus Norvegicus","authors":"S. Jassim, A. M. Hussin","doi":"10.9790/3008-1203045659","DOIUrl":"https://doi.org/10.9790/3008-1203045659","url":null,"abstract":"In the current study the long-term effect of omeprazole was determined by measuring some hematological parameters .Three groups of laboratory rats were taken each group (6) individual, the first groups was the control, second and third were given the drug with a dose of 20 and 40 respectively for three consecutive months. There are significant effects at (p˃0.05) in all parameters which include white and red blood cells counts(WBC and RBC), Hemoglobin concentration(Hb) and the ratio of neutrophils and lymphocytes in both treated groups(the effect is significant for both doses) compared with control, That is, there was a clear effect of omeprazole on the blood picture.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"98 1","pages":"56-59"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90724599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RNA interference is a sequence specific post transcriptional gene silencing mechanism which works through cleaving of nucleic acids by small RNA molecules of 19-21 mers. RNA interference tool found very effective to destroy the pathogenicity of several viruses. The molecular scissor activity of small interfering RNA (siRNA) was applied for inhibition of CoxsackievirusA24 (CA24), an Enterovirus of family Picornaviridae responsible for acute haemorrhagic conjunctivitis in humans. Four different siRNA molecules were used to target 5’ untranslated region (si5U), cis acting replication element of 2C (siCre), RNA dependent RNA polymerase enzyme coding region (si3D pol ) and 3’ untranslated region of CA24. Virus inhibition study by siRNA was done in Hep2 cells. Cytopathic effect, immunofluorescence assay, 50% tissue culture infectious dose (TCID50), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and virus copy number in Real-time PCR assays were used for the validation of virus inhibition potential of designed siRNA. Analysis of cumulative data reflected that si5U and si3D pol are highly efficient to stop CA24 propagation in Hep2 cells. Transfected Hep2 cells with any of these siRNA found refrained for CA24 infection in cell culture, immunofluorescence assay, TCID50 and Real Time PCR assay (p<0.05).
{"title":"Inhibition of Coxsackievirus A24 in permissive Hep2 cells by small interfering RNA (siRNA)","authors":"A. Mishra, G. Satpathy","doi":"10.9790/3008-1203042126","DOIUrl":"https://doi.org/10.9790/3008-1203042126","url":null,"abstract":"RNA interference is a sequence specific post transcriptional gene silencing mechanism which works through cleaving of nucleic acids by small RNA molecules of 19-21 mers. RNA interference tool found very effective to destroy the pathogenicity of several viruses. The molecular scissor activity of small interfering RNA (siRNA) was applied for inhibition of CoxsackievirusA24 (CA24), an Enterovirus of family Picornaviridae responsible for acute haemorrhagic conjunctivitis in humans. Four different siRNA molecules were used to target 5’ untranslated region (si5U), cis acting replication element of 2C (siCre), RNA dependent RNA polymerase enzyme coding region (si3D pol ) and 3’ untranslated region of CA24. Virus inhibition study by siRNA was done in Hep2 cells. Cytopathic effect, immunofluorescence assay, 50% tissue culture infectious dose (TCID50), 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and virus copy number in Real-time PCR assays were used for the validation of virus inhibition potential of designed siRNA. Analysis of cumulative data reflected that si5U and si3D pol are highly efficient to stop CA24 propagation in Hep2 cells. Transfected Hep2 cells with any of these siRNA found refrained for CA24 infection in cell culture, immunofluorescence assay, TCID50 and Real Time PCR assay (p<0.05).","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"43 1","pages":"21-26"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90893986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Skin prick test is one of the more important diagnostic tests against allergic diseases, it uses a synthesized allergic extracts from different allergens. In this study skin prick test was done on 83 allergic persons and 20 controls (54 male and 49 female). The test was done in the Allergic Clinic in the King Abdulaziz University Hospital with 9 different allergens which were isolated from Jeddah city. The used allergens were extract of 2 species of house dust mite, extract of house dust and extracts of 6 species of identified fungi. The extracts were used in the skin prick test and compared with the same commercial allergen extracts, imported from Omega company, Canada. The results revealed a significant difference between the two results and the Canadian extracts were better than the Saudi extracts. Conclusion: From the over mentioned results could concluded that the Saudi allergens able to be applied and gave the valuable results if compared with the imported Canadian allergens which isvery expensive using skin prick test. Also the Saudi allergens need more studies to standardize to give promising economic impact results.
{"title":"Studies on Skin Sensitivity to Various Allergens in Jeddah, Saudi Arabia Using Skin Prick Test","authors":"Eman Beyari, Hussein A. Almehdar","doi":"10.9790/3008-1203023540","DOIUrl":"https://doi.org/10.9790/3008-1203023540","url":null,"abstract":"Skin prick test is one of the more important diagnostic tests against allergic diseases, it uses a synthesized allergic extracts from different allergens. In this study skin prick test was done on 83 allergic persons and 20 controls (54 male and 49 female). The test was done in the Allergic Clinic in the King Abdulaziz University Hospital with 9 different allergens which were isolated from Jeddah city. The used allergens were extract of 2 species of house dust mite, extract of house dust and extracts of 6 species of identified fungi. The extracts were used in the skin prick test and compared with the same commercial allergen extracts, imported from Omega company, Canada. The results revealed a significant difference between the two results and the Canadian extracts were better than the Saudi extracts. Conclusion: From the over mentioned results could concluded that the Saudi allergens able to be applied and gave the valuable results if compared with the imported Canadian allergens which isvery expensive using skin prick test. Also the Saudi allergens need more studies to standardize to give promising economic impact results.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"2 1","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88925947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plants have been the part of life forms even with the progenitors of man. Term “Ethnobotany” was coined to denote use of plants by human being.Ethnobotany deals with the direct relationship of plants with man. The term today has come to denote the entire realm of direct relationship between plant and man. Plants show enormous diversity in the form of Algae, Fungi, Bryophytes, Pteridophytes, Gymnosperms, and Angiosperms of which later are the most diversified plants. Present study focuses on ethnobotanical study of one of the largest family of Angiosperms, the family Leguminosae, of Raipur city area. Leguminosae include three subfamilies viz: Papilionoideae, Caesalpinoideae and Mimosoideae. The family has approximately 18,000 species grouped into around 650 genera with cosmopolitan distribution. During the study seasonal field survey has been made. Information about the plants were obtained by interviewing the common people and folk healers. During the study 8 plant species were found to be used as pulses, 2 plant species (Glycine max andArachis hypogea) as edible oil yielding plants, 9 plant species used in different socio religious ceremonies (eg. Butea monosperma, Acacia catechu,Prosopis cineraria, Acacia pycnthus, Vigna sps ), 7 plant species as vegetable (eg. Trigonellafoenum-graecum), 3 species as dye yielding plants (e.g. Butea monosperma), 26 plants used in traditional medicine (e.g Cassia occidentalis, Acacia concinna, Psoralea corylifolia, Dolichos biflorus, Mucuna pruriens), 7 plants species are Non-wood Forest Produces (NWFPs), (e.g. Acacia nilotica), 13 plants are used as timber yielding plants e.g. Dalbergia sissoo). Some are fodder plants (e.g. Leucaena leucophloea) and 2 plant species are used as tooth brush (e.gAcacia nilotica) and some plants yields fibre. Some Weeds of this family are used to increase the fertility of soil due to the capacity of nitrogen fixation eg. Aeshchynomene indica,and Lathyrus odoratus. Conservation practices of plants of this family have been observed during the present studies.
{"title":"Ethnobotanical Survey of Uses of Leguminosae in Raipur District","authors":"P. Dewangan, Acharya","doi":"10.9790/3008-1203021217","DOIUrl":"https://doi.org/10.9790/3008-1203021217","url":null,"abstract":"Plants have been the part of life forms even with the progenitors of man. Term “Ethnobotany” was coined to denote use of plants by human being.Ethnobotany deals with the direct relationship of plants with man. The term today has come to denote the entire realm of direct relationship between plant and man. Plants show enormous diversity in the form of Algae, Fungi, Bryophytes, Pteridophytes, Gymnosperms, and Angiosperms of which later are the most diversified plants. Present study focuses on ethnobotanical study of one of the largest family of Angiosperms, the family Leguminosae, of Raipur city area. Leguminosae include three subfamilies viz: Papilionoideae, Caesalpinoideae and Mimosoideae. The family has approximately 18,000 species grouped into around 650 genera with cosmopolitan distribution. During the study seasonal field survey has been made. Information about the plants were obtained by interviewing the common people and folk healers. During the study 8 plant species were found to be used as pulses, 2 plant species (Glycine max andArachis hypogea) as edible oil yielding plants, 9 plant species used in different socio religious ceremonies (eg. Butea monosperma, Acacia catechu,Prosopis cineraria, Acacia pycnthus, Vigna sps ), 7 plant species as vegetable (eg. Trigonellafoenum-graecum), 3 species as dye yielding plants (e.g. Butea monosperma), 26 plants used in traditional medicine (e.g Cassia occidentalis, Acacia concinna, Psoralea corylifolia, Dolichos biflorus, Mucuna pruriens), 7 plants species are Non-wood Forest Produces (NWFPs), (e.g. Acacia nilotica), 13 plants are used as timber yielding plants e.g. Dalbergia sissoo). Some are fodder plants (e.g. Leucaena leucophloea) and 2 plant species are used as tooth brush (e.gAcacia nilotica) and some plants yields fibre. Some Weeds of this family are used to increase the fertility of soil due to the capacity of nitrogen fixation eg. Aeshchynomene indica,and Lathyrus odoratus. Conservation practices of plants of this family have been observed during the present studies.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"137 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89148985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plate Tectonics and Reality","authors":"D. Mitra","doi":"10.9790/3008-1203013539","DOIUrl":"https://doi.org/10.9790/3008-1203013539","url":null,"abstract":"","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"1 1","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88248397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramipril is an ACE inhibitor mainly used for management of mild to severe hypertension and myocardial infarction. The poor solubility and wettability of Ramipril leads to poor dissolution and hence showing variations in bioavailability.The present study is aimed to improve the physicochemical properties of the drug using solid dispersion [SD] techniques. Solid dispersions [SDs] of ramipril were prepared with different polymers or carriers such as polyvinylpyrrolidone (PVP K25, PVP K30 and PVP K90), polyethylene glycol (PEG 4000 and PEG 6000) at three drug : carrier ratios (1:1), (1:2) and (1:3). Different methods such as melting and kneading methods were used. The formulations were characterized by X-Ray Diffractometry studies, Fourier transform infrared spectroscopy and in vitro dissolution rate studies. In contrast to the slow dissolution rate of pure Ramipril, the dispersion of the drug in the PEG4000 or 6000 considerably enhanced the dissolution rate. Furthermore; Ramipril 10 mg immediate release tablets prepared in a ratio of 1:1 (drug: carrier) by the fusion method has been resulted in an acceptable dissolution results; 91% and 97% for ramiprilPEG4000 and ramipril-PEG6000 respectively.
{"title":"Enhancement of Dissolution Rate of Ramipril Tablets by Solid Dispersion Technique","authors":"A. M. Hay, S. Adawy","doi":"10.9790/3008-1203015562","DOIUrl":"https://doi.org/10.9790/3008-1203015562","url":null,"abstract":"Ramipril is an ACE inhibitor mainly used for management of mild to severe hypertension and myocardial infarction. The poor solubility and wettability of Ramipril leads to poor dissolution and hence showing variations in bioavailability.The present study is aimed to improve the physicochemical properties of the drug using solid dispersion [SD] techniques. Solid dispersions [SDs] of ramipril were prepared with different polymers or carriers such as polyvinylpyrrolidone (PVP K25, PVP K30 and PVP K90), polyethylene glycol (PEG 4000 and PEG 6000) at three drug : carrier ratios (1:1), (1:2) and (1:3). Different methods such as melting and kneading methods were used. The formulations were characterized by X-Ray Diffractometry studies, Fourier transform infrared spectroscopy and in vitro dissolution rate studies. In contrast to the slow dissolution rate of pure Ramipril, the dispersion of the drug in the PEG4000 or 6000 considerably enhanced the dissolution rate. Furthermore; Ramipril 10 mg immediate release tablets prepared in a ratio of 1:1 (drug: carrier) by the fusion method has been resulted in an acceptable dissolution results; 91% and 97% for ramiprilPEG4000 and ramipril-PEG6000 respectively.","PeriodicalId":14548,"journal":{"name":"IOSR Journal of Pharmacy and Biological Sciences","volume":"115 1","pages":"55-62"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79436706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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