Pub Date : 2020-06-06DOI: 10.30500/IVSA.2020.224068.1211
Guanghao Lin, Liming Chen, Youfeng Xu, P. Wei
Abstract: An Asian elephant at Youngor Zoo in Ningbo sufferred from a disease called hoof disease, it characterized that the part of pad fallen off. This disease deteriorated rapidly, and then affect the whole body. With the poor effect of strengthening the nursing of the foot , we fixed elephant′s foot by using artificial steel plate and sternal wire. At the same time,we also adjust the formula of elephants food, improve the environment of the captive and trim the its hoof properly. The great treatment result shows that the method can be initially applied to the treatment of hoof disease. This report shows how the utilization of plate and can be extremely useful for treatment of this condition in elephant.
{"title":"Treatment of hoof disease in an Asian elephant(elephas maximus) using creative surgery:a successful case report","authors":"Guanghao Lin, Liming Chen, Youfeng Xu, P. Wei","doi":"10.30500/IVSA.2020.224068.1211","DOIUrl":"https://doi.org/10.30500/IVSA.2020.224068.1211","url":null,"abstract":"Abstract: An Asian elephant at Youngor Zoo in Ningbo sufferred from a disease called hoof disease, it characterized that the part of pad fallen off. This disease deteriorated rapidly, and then affect the whole body. With the poor effect of strengthening the nursing of the foot , we fixed elephant′s foot by using artificial steel plate and sternal wire. At the same time,we also adjust the formula of elephants food, improve the environment of the captive and trim the its hoof properly. The great treatment result shows that the method can be initially applied to the treatment of hoof disease. This report shows how the utilization of plate and can be extremely useful for treatment of this condition in elephant.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"168-172"},"PeriodicalIF":0.0,"publicationDate":"2020-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49579701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-04DOI: 10.30500/IVSA.2020.211743.1205
M. Khordadmehr, J. Ashrafihelan, D. Azizi, Sadegh Haghparast
Background- Neoplastic diseases are one of the main factors that threaten the life span of pet birds. Osteoma and osteosarcoma are considered as the most prevalent of neoplasms in the skeletal system, which were reported in several species of the birds.Case Description- This paper describes gross and histopathological features of telangiectatic osteosarcoma in an adult male budgerigar (Melopsittacus undulatus) with weakness, general depression and weight loss. Clinical Findings- At necropsy, a firm mass with approximately one cm in size and brown color involved the tibiotarsus. Pathology examination of the mass indicated bloody cystic lesions accompanied by occasional spicules of osteoid between pleomorphic mesenchymal cells, which it was found minimal. Clinical Relevance- Telangiectatic osteosarcoma should be differentiated from either hemangiosarcoma or aneurysmal bone cyst. This is the first report of osteosarcoma in the budgerigar.
{"title":"Telangiectatic Osteosarcoma in a Budgerigar (Melopsittacus undulatus) - Pathological Findings","authors":"M. Khordadmehr, J. Ashrafihelan, D. Azizi, Sadegh Haghparast","doi":"10.30500/IVSA.2020.211743.1205","DOIUrl":"https://doi.org/10.30500/IVSA.2020.211743.1205","url":null,"abstract":"Background- Neoplastic diseases are one of the main factors that threaten the life span of pet birds. Osteoma and osteosarcoma are considered as the most prevalent of neoplasms in the skeletal system, which were reported in several species of the birds.Case Description- This paper describes gross and histopathological features of telangiectatic osteosarcoma in an adult male budgerigar (Melopsittacus undulatus) with weakness, general depression and weight loss. Clinical Findings- At necropsy, a firm mass with approximately one cm in size and brown color involved the tibiotarsus. Pathology examination of the mass indicated bloody cystic lesions accompanied by occasional spicules of osteoid between pleomorphic mesenchymal cells, which it was found minimal. Clinical Relevance- Telangiectatic osteosarcoma should be differentiated from either hemangiosarcoma or aneurysmal bone cyst. This is the first report of osteosarcoma in the budgerigar.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"157-159"},"PeriodicalIF":0.0,"publicationDate":"2020-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42009242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-07DOI: 10.30500/IVSA.2020.211093.1204
Rahman Allahvirdizadeh, R. Mohammadi, A. Tehrani, V. Najarnezhad
Case Description- A four-month-old female Holstein calf was presented to the Veterinary Teaching Hospital of Urmia University with a history of abnormal hairy growth on the right eye since birth. Clinical Findings- On general examination, the animal was alert. Body temperature, heart rate, respiratory rate, menace test, and pupillary light reflex were normal. On ophthalmic examination, a hairy mass was observed on the conjunctivae, third eyelid, sclera, and cornea of the right eye. Histopathological examination revealed the mass with three distinct areas of skin. It was diagnosed as an ocular dermoid cyst and surgical treatment was warranted. Treatment and Outcome- The mass was surgically excised to prevent damage to the anterior chamber of the eye. Ocular healing was satisfactory in a 4 week follow up. Clinical Relevance- This report described an ocular dermoid cyst in a four-month Holstein calf. There was just lacrimation, possibly due to irritation caused by the hairs. The ocular dermoid cyst could be excised surgically, and the prognosis is good.
{"title":"Ocular Dermoid Cyst in a Four-Month-Old Holstein Calf","authors":"Rahman Allahvirdizadeh, R. Mohammadi, A. Tehrani, V. Najarnezhad","doi":"10.30500/IVSA.2020.211093.1204","DOIUrl":"https://doi.org/10.30500/IVSA.2020.211093.1204","url":null,"abstract":"Case Description- A four-month-old female Holstein calf was presented to the Veterinary Teaching Hospital of Urmia University with a history of abnormal hairy growth on the right eye since birth. Clinical Findings- On general examination, the animal was alert. Body temperature, heart rate, respiratory rate, menace test, and pupillary light reflex were normal. On ophthalmic examination, a hairy mass was observed on the conjunctivae, third eyelid, sclera, and cornea of the right eye. Histopathological examination revealed the mass with three distinct areas of skin. It was diagnosed as an ocular dermoid cyst and surgical treatment was warranted. Treatment and Outcome- The mass was surgically excised to prevent damage to the anterior chamber of the eye. Ocular healing was satisfactory in a 4 week follow up. Clinical Relevance- This report described an ocular dermoid cyst in a four-month Holstein calf. There was just lacrimation, possibly due to irritation caused by the hairs. The ocular dermoid cyst could be excised surgically, and the prognosis is good.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"160-163"},"PeriodicalIF":0.0,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42549832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.22034/IVSA.2019.193913.1191
A. Raisi, Farshid Davoodi, Soroush Afshar-Ghahremani, Shayan Taheri, S. Sharifi, M. Adel
Objective- The present study describes the anesthetic effects of essential oil of Lavender (Lavandula officinalis) in Convict cichlid fish (Cichlasoma nigrofasciata) in comparison with clove powder (Syzygium aromaticum).Study Design- experimental studyAnimals- 25 Juvenile Convict cichlid fish with unknown sex and an average weight of 4.2 ± 0.5 g were used (n = 5 for each experimental group per experiment).Methods- The fish were divided into five groups, initially with five fish per group. Each group was subjected to one of four final concentrations [0.3 and 0.5 g/l] of clove powder and [1.8 and 3 cc/l] essential oil of Lavender and control group was for determination of the basal values for blood parameters. The times for sedation, pre-anesthesia, and anesthesia were recorded based on the behavioral events seen after exposing the fish to each aquarium. After induction of anesthesia, the fish were transferred to anesthetic-free aquariums, and recovery time was recorded. Blood samples were taken by dissecting peduncle just 30 minutes after fish were placed in water contain anesthetics.Results- essential oil of Lavender had efficacy to anesthetize the fish, and its sedation was similar to the clove powder at a commensurate concentration in Convict cichlid fish. However, the anesthesia form was different.Conclusions and Clinical Relevance- Lavender oil as a sedative and anesthetic agent can be used in fish
{"title":"Evaluation of the Anesthetic and Tranquilizing Effects of Clove Powder (Syzygium aromaticum) and Lavender Oil (Lavandula officinalis) in Convict Cichlid Fish (Cichlasoma nigrofasciata)","authors":"A. Raisi, Farshid Davoodi, Soroush Afshar-Ghahremani, Shayan Taheri, S. Sharifi, M. Adel","doi":"10.22034/IVSA.2019.193913.1191","DOIUrl":"https://doi.org/10.22034/IVSA.2019.193913.1191","url":null,"abstract":"Objective- The present study describes the anesthetic effects of essential oil of Lavender (Lavandula officinalis) in Convict cichlid fish (Cichlasoma nigrofasciata) in comparison with clove powder (Syzygium aromaticum).Study Design- experimental studyAnimals- 25 Juvenile Convict cichlid fish with unknown sex and an average weight of 4.2 ± 0.5 g were used (n = 5 for each experimental group per experiment).Methods- The fish were divided into five groups, initially with five fish per group. Each group was subjected to one of four final concentrations [0.3 and 0.5 g/l] of clove powder and [1.8 and 3 cc/l] essential oil of Lavender and control group was for determination of the basal values for blood parameters. The times for sedation, pre-anesthesia, and anesthesia were recorded based on the behavioral events seen after exposing the fish to each aquarium. After induction of anesthesia, the fish were transferred to anesthetic-free aquariums, and recovery time was recorded. Blood samples were taken by dissecting peduncle just 30 minutes after fish were placed in water contain anesthetics.Results- essential oil of Lavender had efficacy to anesthetize the fish, and its sedation was similar to the clove powder at a commensurate concentration in Convict cichlid fish. However, the anesthesia form was different.Conclusions and Clinical Relevance- Lavender oil as a sedative and anesthetic agent can be used in fish","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41744921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.22034/IVSA.2020.218718.1210
F. Davari, O. Zehtabvar, M. Molazem, Z. Tootian, M. Soltani, Mahdokht Khanamooie-Ashi
Objective- The intention of this research is studying the full topographic characteristics of the lower respiratory tract consist of lungs, bronchi, and trachea in Caspian pond tortoise, especially those features that are applicable in clinical examination, and their proximity to other organs.Design- Experimental study.Animals- Six female adult Caspian Pont turtles (Mauremys Caspica)Procedures- Siemens Somatom spirit Dual Slice CT scan machine has been used. The samples were fixed in ventral recumbency to take CT-scan images. In each sample, the CT-scan was done in both fixed limb and neck and extended form. Some morphometric parameters like the volume of the coelomic cavity, right and left lungs, and others were measured through the Syngo MMWP VE40A software.Results- Trachea passing a short distance in the midline of the neck, and deviated to the left; then, it entered to the coelomic cavity. The tracheal bifurcation site was movable and move to caudal parts with neck flexion. The entrance site of the bronchi to the lungs was fixed. With the consideration of coelomic cavity volume and various parts of that in the neck extended position, the lungs consist of 42.12% of the coelomic cavity and 22.58% in the flexed neck position.Conclusion and Clinical Relevance- According to the observations, we can say the flexion of the neck leads to some alterations in the tracheal bifurcation site and locating posteriorly to the lungs hilum. As a result, the way of the bronchus changes to inter the lungs. The branches of bronchus in these turtles also are like other reptiles, and it's not similar to a bronchial tree and it contains just limited small branches. The CT-scan is applicable for alive animals, so this is one of the best choices for anatomical studies in animals who are in danger of extinction.
{"title":"Computed Tomographic Anatomy of the Trachea, Bronchi and Lungs in the Caspian Pond Turtle (Mauremys caspica)","authors":"F. Davari, O. Zehtabvar, M. Molazem, Z. Tootian, M. Soltani, Mahdokht Khanamooie-Ashi","doi":"10.22034/IVSA.2020.218718.1210","DOIUrl":"https://doi.org/10.22034/IVSA.2020.218718.1210","url":null,"abstract":"Objective- The intention of this research is studying the full topographic characteristics of the lower respiratory tract consist of lungs, bronchi, and trachea in Caspian pond tortoise, especially those features that are applicable in clinical examination, and their proximity to other organs.Design- Experimental study.Animals- Six female adult Caspian Pont turtles (Mauremys Caspica)Procedures- Siemens Somatom spirit Dual Slice CT scan machine has been used. The samples were fixed in ventral recumbency to take CT-scan images. In each sample, the CT-scan was done in both fixed limb and neck and extended form. Some morphometric parameters like the volume of the coelomic cavity, right and left lungs, and others were measured through the Syngo MMWP VE40A software.Results- Trachea passing a short distance in the midline of the neck, and deviated to the left; then, it entered to the coelomic cavity. The tracheal bifurcation site was movable and move to caudal parts with neck flexion. The entrance site of the bronchi to the lungs was fixed. With the consideration of coelomic cavity volume and various parts of that in the neck extended position, the lungs consist of 42.12% of the coelomic cavity and 22.58% in the flexed neck position.Conclusion and Clinical Relevance- According to the observations, we can say the flexion of the neck leads to some alterations in the tracheal bifurcation site and locating posteriorly to the lungs hilum. As a result, the way of the bronchus changes to inter the lungs. The branches of bronchus in these turtles also are like other reptiles, and it's not similar to a bronchial tree and it contains just limited small branches. The CT-scan is applicable for alive animals, so this is one of the best choices for anatomical studies in animals who are in danger of extinction.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"70-77"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46615089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.30500/IVSA.2020.183165.1183
H. Moslemi, Amin Nikpasand, A. Tavakoli, Seyed Mersad Sefidgar
Objective- Due to its specific position, the canine tooth is more exposed to the injuries, fractures and pulp necrosis. In these cases, the damaged teeth are usually pulled out. The root of this tooth is very large and sometimes extends over the premolar teeth. To extract it, a large amount of alveolar bone tissue should be harvested. Moreover, the cavity remains very large, which results in forming a cavity after repairing. It can be very effective in the form of closure of the mouth and lips.Design- Experimental studyAnimals- five adult male dogs Procedures- In this research, five dogs were selected and their maxillary canine teeth in right and left (10 teeth in total) were surgically removed. Then the right dental cavity was filled with insulin PRF and the left one filled with autograft cancellous bone chips. Three weeks after the surgery, the cavity was sampled for histopathological examination. Factors such as epithelialization rate, fibroplasia, fibrotic reaction and intensity of inflammation were studied. Results- The average score obtained from histological studies implies that epithelialization in PRF group is significantly higher than the other group, and there is no significant difference in other parameters.Conclusion and Clinical Relevance- Since PRF preparation is easy, it is not painful and risky for the patient and does not require any special care after the surgery. Therefore, it is used preferably.
{"title":"Comparison of Alveolar Ridge Preservation with Autograft Cancellous Bone Transplant and PRF Following Canine Tooth Extraction in Dog","authors":"H. Moslemi, Amin Nikpasand, A. Tavakoli, Seyed Mersad Sefidgar","doi":"10.30500/IVSA.2020.183165.1183","DOIUrl":"https://doi.org/10.30500/IVSA.2020.183165.1183","url":null,"abstract":"Objective- Due to its specific position, the canine tooth is more exposed to the injuries, fractures and pulp necrosis. In these cases, the damaged teeth are usually pulled out. The root of this tooth is very large and sometimes extends over the premolar teeth. To extract it, a large amount of alveolar bone tissue should be harvested. Moreover, the cavity remains very large, which results in forming a cavity after repairing. It can be very effective in the form of closure of the mouth and lips.Design- Experimental studyAnimals- five adult male dogs Procedures- In this research, five dogs were selected and their maxillary canine teeth in right and left (10 teeth in total) were surgically removed. Then the right dental cavity was filled with insulin PRF and the left one filled with autograft cancellous bone chips. Three weeks after the surgery, the cavity was sampled for histopathological examination. Factors such as epithelialization rate, fibroplasia, fibrotic reaction and intensity of inflammation were studied. Results- The average score obtained from histological studies implies that epithelialization in PRF group is significantly higher than the other group, and there is no significant difference in other parameters.Conclusion and Clinical Relevance- Since PRF preparation is easy, it is not painful and risky for the patient and does not require any special care after the surgery. Therefore, it is used preferably.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47022058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.22034/IVSA/IVSA.2019.201468.1199
M. Javdani, M. Hashemnia, H. D. Rooster
Objective- The current study was conducted to evaluate changes in the urinary bladder structure and leukocyte profile as an important index of the systemic inflammation response for two different types of spinal cord injury (SCI) in a rat model. Design- Experimental Study.Animals- Forty adult healthy female Sprague-Dawley rats.Procedure- Animals were assigned into two equal model groups: the incomplete transection group (ITG) and the contusion group (CG). In both groups, SCI was created at the T9-10 level of the column. Alterations in the urinary bladder construction and changes in the leukocytes were examined in both groups post-surgically. Results- Degenerative changes and a reduction in the cellular volume in the mucous layer, hyperemia, and the presence of inflammatory cells in the submucosa were the most important findings in both SCI groups. The extent of the destructive lesions was more prominent in the CG 14 days after operation. At 28 days after surgery, pathological lesions including leukocyte infiltration in the submucosa, denudation of the urothelial mucosa, severe edema, atrophy of the muscle layer, and necrosis of muscle fibers in some areas were recorded in both groups; the extent and severity of the lesions were more evident in the CG. There was no significant difference between the white blood cells and N/L ratio at the different times in the CG and ITG groups. Conclusion and Clinical Relevance- Despite the similar leukocyte response in the IGT and CG, more severe degenerative histological alternations in the urinary bladder structure were observed in the CG. Therefore, attention should be paid to the extent of cystitis in these patients in clinical trials and interventions.
{"title":"Changes in urinary bladder structure and systemic inflammation response following incomplete transection versus contusion spinal cord injury in rat model","authors":"M. Javdani, M. Hashemnia, H. D. Rooster","doi":"10.22034/IVSA/IVSA.2019.201468.1199","DOIUrl":"https://doi.org/10.22034/IVSA/IVSA.2019.201468.1199","url":null,"abstract":"Objective- The current study was conducted to evaluate changes in the urinary bladder structure and leukocyte profile as an important index of the systemic inflammation response for two different types of spinal cord injury (SCI) in a rat model. Design- Experimental Study.Animals- Forty adult healthy female Sprague-Dawley rats.Procedure- Animals were assigned into two equal model groups: the incomplete transection group (ITG) and the contusion group (CG). In both groups, SCI was created at the T9-10 level of the column. Alterations in the urinary bladder construction and changes in the leukocytes were examined in both groups post-surgically. Results- Degenerative changes and a reduction in the cellular volume in the mucous layer, hyperemia, and the presence of inflammatory cells in the submucosa were the most important findings in both SCI groups. The extent of the destructive lesions was more prominent in the CG 14 days after operation. At 28 days after surgery, pathological lesions including leukocyte infiltration in the submucosa, denudation of the urothelial mucosa, severe edema, atrophy of the muscle layer, and necrosis of muscle fibers in some areas were recorded in both groups; the extent and severity of the lesions were more evident in the CG. There was no significant difference between the white blood cells and N/L ratio at the different times in the CG and ITG groups. Conclusion and Clinical Relevance- Despite the similar leukocyte response in the IGT and CG, more severe degenerative histological alternations in the urinary bladder structure were observed in the CG. Therefore, attention should be paid to the extent of cystitis in these patients in clinical trials and interventions.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45863351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.30500/IVSA.2020.208499.1203
Hamid Shamsi, M. Velayati, Hakim Rahimzadeh, N. Mozafari, R. Mazaheri, Khameneh
Objective- In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.Design- Experimental StudyAnimals- Forty male diabetic Wistar ratsProcedures- The animals were randomized into four groups of ten animals each. Induction of diabetes was achieved using 60 mg/kg streptozotocin. In group I, 0.1 mL sterile saline 0.9% solution was added to the wounds with no dressing. In group II, the wounds were dressed with chitosan thin-film membranes. In group III, the wounds were treated with curcumin nanoparticles. In group IV, animals with were dressed with chitosan nanocurcumin biofilm. Results- Planimetric, histological and quantitative morphometric studies and determination of hydroxyproline levels showed that there was significant difference between animals in group IV compared to other groups (p = 0.001). Conclusion and clinical relevance- Chitosan nanocurcumin biofilm improved healing of diabetic wound in rats
{"title":"Beneficial Effects of Nanocurcumin Loaded Chitosan Biofilm on Healing of Full Thickness Excisional Wounds in Diabetic Rats","authors":"Hamid Shamsi, M. Velayati, Hakim Rahimzadeh, N. Mozafari, R. Mazaheri, Khameneh","doi":"10.30500/IVSA.2020.208499.1203","DOIUrl":"https://doi.org/10.30500/IVSA.2020.208499.1203","url":null,"abstract":"Objective- In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.Design- Experimental StudyAnimals- Forty male diabetic Wistar ratsProcedures- The animals were randomized into four groups of ten animals each. Induction of diabetes was achieved using 60 mg/kg streptozotocin. In group I, 0.1 mL sterile saline 0.9% solution was added to the wounds with no dressing. In group II, the wounds were dressed with chitosan thin-film membranes. In group III, the wounds were treated with curcumin nanoparticles. In group IV, animals with were dressed with chitosan nanocurcumin biofilm. Results- Planimetric, histological and quantitative morphometric studies and determination of hydroxyproline levels showed that there was significant difference between animals in group IV compared to other groups (p = 0.001). Conclusion and clinical relevance- Chitosan nanocurcumin biofilm improved healing of diabetic wound in rats","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"32-41"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45439563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.22034/IVSA.2020.189763.1186
E. Tamaddonfard, A. Erfanparast, Sina Tamaddonfard, Nabat Nagshbandi, S. Naderi
Objective- Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in rats. To explore the possible mechanism, yohimbine (an α2-adrenergic receptor antagonist) was also used. Design- An experimental study. Animals– Forty-eight healthy male Wistar rats. Procedures– Rats were divided into eight groups with six rats in each group to receive intraperitoneal injection of normal saline, oral administration of curcumin (12.5, 50 and 200 mg/kg), intraperitoneal injection of yohimbine (0.5 and 2 mg/kg), and oral administration of curcumin (12.5 mg/kg) plus intraperitoneal injection of yohimbine (0.5 mg/kg). After these treatments, ketamine (100 mg/kg) and xylazine (10 mg/kg) were intraperitoneally administered to all groups. Blood glucose concentration was measured at 60 and 5 min before and at, 30, 60, 90 and 120 min after ketamine-xylazine injection. Serum insulin concentration was measured by ELISA kit at the end of experiment. Results- Ketamin-xylazine increased blood glucose and decreased serum insulin. Curcumin lowered increased blood glucose and increased decreased serum insulin. Yohimbine prevented the hyperglycemia and hypoinsulinemia induced by ketamin-xylazine produced the same results as curcumin. Low doses of curcumin and yohimbine induced documented hypoglycemic and hyperinsulinemic effects. Conclusion and Clinical Relevance- Based on the results, it is concluded that curcumin improves hyperglycemia and hypoinsulinemia induced by ketamine- xylazine and α2-adrenergic receptor may involve in this effect.
{"title":"Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor","authors":"E. Tamaddonfard, A. Erfanparast, Sina Tamaddonfard, Nabat Nagshbandi, S. Naderi","doi":"10.22034/IVSA.2020.189763.1186","DOIUrl":"https://doi.org/10.22034/IVSA.2020.189763.1186","url":null,"abstract":"Objective- Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in rats. To explore the possible mechanism, yohimbine (an α2-adrenergic receptor antagonist) was also used. Design- An experimental study. Animals– Forty-eight healthy male Wistar rats. Procedures– Rats were divided into eight groups with six rats in each group to receive intraperitoneal injection of normal saline, oral administration of curcumin (12.5, 50 and 200 mg/kg), intraperitoneal injection of yohimbine (0.5 and 2 mg/kg), and oral administration of curcumin (12.5 mg/kg) plus intraperitoneal injection of yohimbine (0.5 mg/kg). After these treatments, ketamine (100 mg/kg) and xylazine (10 mg/kg) were intraperitoneally administered to all groups. Blood glucose concentration was measured at 60 and 5 min before and at, 30, 60, 90 and 120 min after ketamine-xylazine injection. Serum insulin concentration was measured by ELISA kit at the end of experiment. Results- Ketamin-xylazine increased blood glucose and decreased serum insulin. Curcumin lowered increased blood glucose and increased decreased serum insulin. Yohimbine prevented the hyperglycemia and hypoinsulinemia induced by ketamin-xylazine produced the same results as curcumin. Low doses of curcumin and yohimbine induced documented hypoglycemic and hyperinsulinemic effects. Conclusion and Clinical Relevance- Based on the results, it is concluded that curcumin improves hyperglycemia and hypoinsulinemia induced by ketamine- xylazine and α2-adrenergic receptor may involve in this effect.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"53-61"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44065206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-01DOI: 10.30500/IVSA.2020.195638.1193
S. Moghadam, A. Amniattalab
Objective- Chitosan is of great interest in regenerative medicine because of its plentiful properties, like biocompatibility, biodegradability and non-toxicity. The objective of the present study was histopathological and biomechanical survey on effect of CoQ10 in combination with chitosan conduit on deep digital flexor tendon (DDFT) healing in rabbits. Design- Experimental Study Animals- Eighteen healthy male white New Zealand rabbits Procedures- The animals were randomized into three groups of 6 animals each. In Controlgroup the DDF tenotomy was performed and the stumps were sutured. In Chitosan group the DDF tenotomy was performed and the stumps were sutured and chitosan conduit was wrapped around the damaged area. In Chit-CoQ10 group the procedure was the same as Chitosan group as well as local administration of 100 µL CoQ10 (100 µg/rabbit) into the Chitosan conduit. The histopathological assessments including inflammation, angiogenesis and collagen fibers arrangement, and biomechanical assessments were performed after 8 weeks. Results- Histopathological observations showed that the conduit was absorbed and adhesion around the tendon was deceased in Chitosan and Chit-CoQ10 groups. The biomechanical parameters showed significant improvement in Chit-CoQ10 group (p < 0.05). There were no noticeable signs of infection and tissue reaction in the granulation tissue in Chit-CoQ10 group compared to other groups (p < 0.05). Conclusion and Clinical Relevance- Local administration of CoQ10 in combination with chitosan conduit could accelerate deep digital flexor tendon healing via decrease in adhesion around the tendon with no signs of excessive tissue reaction or infection in rabbits.
{"title":"Histopathological and Biomechanical Survey on Effect of CoQ10 in Combination with Chitosan Conduit on Deep Digital Flexor Tendon Healing in Rabbits","authors":"S. Moghadam, A. Amniattalab","doi":"10.30500/IVSA.2020.195638.1193","DOIUrl":"https://doi.org/10.30500/IVSA.2020.195638.1193","url":null,"abstract":"Objective- Chitosan is of great interest in regenerative medicine because of its plentiful properties, like biocompatibility, biodegradability and non-toxicity. The objective of the present study was histopathological and biomechanical survey on effect of CoQ10 in combination with chitosan conduit on deep digital flexor tendon (DDFT) healing in rabbits. Design- Experimental Study Animals- Eighteen healthy male white New Zealand rabbits Procedures- The animals were randomized into three groups of 6 animals each. In Controlgroup the DDF tenotomy was performed and the stumps were sutured. In Chitosan group the DDF tenotomy was performed and the stumps were sutured and chitosan conduit was wrapped around the damaged area. In Chit-CoQ10 group the procedure was the same as Chitosan group as well as local administration of 100 µL CoQ10 (100 µg/rabbit) into the Chitosan conduit. The histopathological assessments including inflammation, angiogenesis and collagen fibers arrangement, and biomechanical assessments were performed after 8 weeks. Results- Histopathological observations showed that the conduit was absorbed and adhesion around the tendon was deceased in Chitosan and Chit-CoQ10 groups. The biomechanical parameters showed significant improvement in Chit-CoQ10 group (p < 0.05). There were no noticeable signs of infection and tissue reaction in the granulation tissue in Chit-CoQ10 group compared to other groups (p < 0.05). Conclusion and Clinical Relevance- Local administration of CoQ10 in combination with chitosan conduit could accelerate deep digital flexor tendon healing via decrease in adhesion around the tendon with no signs of excessive tissue reaction or infection in rabbits.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"15-23"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45726830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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