Pub Date : 2020-12-01DOI: 10.30500/IVSA.2020.254705.1230
M. Mohseni, A. Jahandideh, G. Abedi, A. Akbarzadeh, S. Hesaraki
Objective- The loss of bone fragments, often due to trauma, infection, mass loss, or even complete bone regeneration after complicated fractures, is one of the constant challenges in medicine and veterinary medicine. The aim of this study was to fabricate and use a nanocomposite scaffold in segmental bone healing in rabbits.Design- Experimental StudyAnimals- Forty adult male New Zealand male rabbitsProcedures- The animals were randomly divided into four groups of 10 animals each. On femur of each rabbit a bilateral 6 mm diameter defect was created. In the first group (control), no substance was used, in the second group, hydroxyapatite, in the third group, nanocomposite tri-calcium phosphate (TCP) and in fourth group, autograft was used to fill the defect. Bone specimens were harvested for histopathological evaluations on days 15 and 60 for evaluation of four indices of union, spongiosa, cortex and bone marrow. Results- The results of using nanocomposite tricalcium phosphate in comparison with other groups were significantly different in all cases. Conclusion and Clinical Relevance- It could be admitted that nanocomposite tri-calcium phosphate scaffold had a positive effect on the healing process and showed satisfactory bone strength, therefore, it could be widely used in orthopedic surgery as well as tissue engineering.
{"title":"Fabrication and Usage of a Nanocomposite Scaffold in Segmental Bone Healing: An Animal Model Study","authors":"M. Mohseni, A. Jahandideh, G. Abedi, A. Akbarzadeh, S. Hesaraki","doi":"10.30500/IVSA.2020.254705.1230","DOIUrl":"https://doi.org/10.30500/IVSA.2020.254705.1230","url":null,"abstract":"Objective- The loss of bone fragments, often due to trauma, infection, mass loss, or even complete bone regeneration after complicated fractures, is one of the constant challenges in medicine and veterinary medicine. The aim of this study was to fabricate and use a nanocomposite scaffold in segmental bone healing in rabbits.Design- Experimental StudyAnimals- Forty adult male New Zealand male rabbitsProcedures- The animals were randomly divided into four groups of 10 animals each. On femur of each rabbit a bilateral 6 mm diameter defect was created. In the first group (control), no substance was used, in the second group, hydroxyapatite, in the third group, nanocomposite tri-calcium phosphate (TCP) and in fourth group, autograft was used to fill the defect. Bone specimens were harvested for histopathological evaluations on days 15 and 60 for evaluation of four indices of union, spongiosa, cortex and bone marrow. Results- The results of using nanocomposite tricalcium phosphate in comparison with other groups were significantly different in all cases. Conclusion and Clinical Relevance- It could be admitted that nanocomposite tri-calcium phosphate scaffold had a positive effect on the healing process and showed satisfactory bone strength, therefore, it could be widely used in orthopedic surgery as well as tissue engineering.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"133-140"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48228018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30500/IVSA.2019.152488.1162
A. Raisi, Ali Aleseyedan, Afshar Roomiani, A. Zakian, P. Barzegar
Case Description- The most important causes of abomasal fistulation have been described in association with umbilical hernia and infection and trauma. A 2-month-old male lamb with an open orifice on the ventral abdomen was referred to the veterinary teaching hospital (VTH) of Lorestan University.Clinical Findings- In this case, the lamb had the abomaso-cutaneous fistula due to unknown penetrating trauma. According to the owner's claim, the above-mentioned non-painful orifice was occurred in the ventral midline due to the rupture of abdominal swelling approximately 45 days ago. On physical examination, heart rate, respiratory rate, and body temperature were normal, but CBC showed slight neutrophilia and mild anemia.Treatment and Outcomes- After local anesthesia around the fistula, the abomasum adhering to the ventral muscular ring was dissected and closed. Then the muscular ring was closed in a vertical mattress pattern and subcutaneous tissue and skin were sutured in the usual method.Clinical Relevance- During the fistula examination through the surgical operation, a muscular ring surrounded by fibrous margins was observed with partial abomasal herniation from the muscular defect. Seemed that adhesion between the abomasum and subcutaneous tissue had prevented the development of diffused peritonitis. Early proper surgical intervention is useful for the treatment of trauma-induced abomaso-cutaneous fistulae in ruminants.
{"title":"Surgical Management of the Trauma-Induced Abomaso-Cutaneous Fistula in a Lamb","authors":"A. Raisi, Ali Aleseyedan, Afshar Roomiani, A. Zakian, P. Barzegar","doi":"10.30500/IVSA.2019.152488.1162","DOIUrl":"https://doi.org/10.30500/IVSA.2019.152488.1162","url":null,"abstract":"Case Description- The most important causes of abomasal fistulation have been described in association with umbilical hernia and infection and trauma. A 2-month-old male lamb with an open orifice on the ventral abdomen was referred to the veterinary teaching hospital (VTH) of Lorestan University.Clinical Findings- In this case, the lamb had the abomaso-cutaneous fistula due to unknown penetrating trauma. According to the owner's claim, the above-mentioned non-painful orifice was occurred in the ventral midline due to the rupture of abdominal swelling approximately 45 days ago. On physical examination, heart rate, respiratory rate, and body temperature were normal, but CBC showed slight neutrophilia and mild anemia.Treatment and Outcomes- After local anesthesia around the fistula, the abomasum adhering to the ventral muscular ring was dissected and closed. Then the muscular ring was closed in a vertical mattress pattern and subcutaneous tissue and skin were sutured in the usual method.Clinical Relevance- During the fistula examination through the surgical operation, a muscular ring surrounded by fibrous margins was observed with partial abomasal herniation from the muscular defect. Seemed that adhesion between the abomasum and subcutaneous tissue had prevented the development of diffused peritonitis. Early proper surgical intervention is useful for the treatment of trauma-induced abomaso-cutaneous fistulae in ruminants.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"164-167"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47823132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.30500/IVSA.2020.248476.1226
Reza Bajelani, Elham Moghtadaei-Khorasgani, M. Moghtadaei
Objective- Veterinary and human orthopedics is widely applied to stimulate fracture healing, accelerate junction connection, and repair bone defects. In this regard, several studies have been conducted on selecting the best material for bone repair. This study aimed to evaluate the effect of aqueous extract of Elaeagnus angustifolia fruit on the process of bone repair in a rabbit animal model. Design- Experimental Study Animals- For this purpose, 12 rabbits were obtained. Procedures- Rabbits randomly divided into 3 groups. The control group, in which a two-sided hole was created in the femur and did not receive the treatment. The second group underwent surgery and received an aqueous extract of Elaeagnus angustifolia fruit at a dose of 250 mg/kg, and the third group received 500 mg/kg intraperitoneal. On weeks 2 and 4 following the bone defect, a histopathologic sample was taken from the site. The bone tissue samples were stained with hematoxylin and eosin. Results-According to histopathologic results, the best and weakest performances occurred in the group treated with 500 mg/kg of extract and in the control group, respectively. This group had a significant difference with other groups in terms of osteoplasia (p < 0.05). Conclusion and Clinical Relevance- In general, the results showed that the aqueous extract of Elaeagnus angustifolia can play an important role in the healing of bone fractures.
{"title":"Histopathologic Study of the Repair of a Minor Defect in Femur Using Elaeagnus angustifolia Extract in Rabbit","authors":"Reza Bajelani, Elham Moghtadaei-Khorasgani, M. Moghtadaei","doi":"10.30500/IVSA.2020.248476.1226","DOIUrl":"https://doi.org/10.30500/IVSA.2020.248476.1226","url":null,"abstract":"Objective- Veterinary and human orthopedics is widely applied to stimulate fracture healing, accelerate junction connection, and repair bone defects. In this regard, several studies have been conducted on selecting the best material for bone repair. This study aimed to evaluate the effect of aqueous extract of Elaeagnus angustifolia fruit on the process of bone repair in a rabbit animal model. Design- Experimental Study Animals- For this purpose, 12 rabbits were obtained. Procedures- Rabbits randomly divided into 3 groups. The control group, in which a two-sided hole was created in the femur and did not receive the treatment. The second group underwent surgery and received an aqueous extract of Elaeagnus angustifolia fruit at a dose of 250 mg/kg, and the third group received 500 mg/kg intraperitoneal. On weeks 2 and 4 following the bone defect, a histopathologic sample was taken from the site. The bone tissue samples were stained with hematoxylin and eosin. Results-According to histopathologic results, the best and weakest performances occurred in the group treated with 500 mg/kg of extract and in the control group, respectively. This group had a significant difference with other groups in terms of osteoplasia (p < 0.05). Conclusion and Clinical Relevance- In general, the results showed that the aqueous extract of Elaeagnus angustifolia can play an important role in the healing of bone fractures.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"141-146"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44858619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-01DOI: 10.30500/IVSA.2020.245724.1223
C. M. Tarif, Subhasish Roy, P. Mukherjee, Kazem, Anyam Vijay Kishore, C. Saha, S. Nandi
Case Description- A nine years old New Zealand white female diabetic rabbit (blood glucose level~300 mg/dl) was presented to the Department of Veterinary Clinical Complex OPD, Kolkata, India with a history of chronic weight loss along with inappetence, polyuria, haematuria from last 10 days. Feeding history revealed that the animal was maintained with a mixed diet that is rich in calcium (Ca). Clinical Findings- Manual examination revealed moderate pain near the caudal region and a hard mass was felt near the bladder region and a straight lateral radiograph of the abdomen revealed the presence of a radiodense cystolith.Treatment and Outcome- Cystotomy was done and the rabbit was recovered uneventfully. The analysis of the stone revealed calcium carbonate as the major content. Clinical Relevance- The present article describes successful surgical management of urolith in a rabbit and confers ample evidence that a high calcium diet, peculiar Ca metabolism along with more carbohydrate predisposing to diabetes may setup urolithiasis. The present study also emphasizes the fact that diminished Na+-K+-ATPase activity in diabetes can play a pivotal role in the pathogenesis of peripheral vascular and neural complications leading to the development of bladder dysfunction, hence diminished urine flow in diabetic rabbits results in the development of nidus formation and thereby further accumulation of calcium salts in and around nidus leads to the formation of urolithiasis.
{"title":"Calcium Carbonate Urolithiasis in a Diabetic Pet Rabbit Fed with High Dietary Calcium - Causal Effect Study and its Surgical Management","authors":"C. M. Tarif, Subhasish Roy, P. Mukherjee, Kazem, Anyam Vijay Kishore, C. Saha, S. Nandi","doi":"10.30500/IVSA.2020.245724.1223","DOIUrl":"https://doi.org/10.30500/IVSA.2020.245724.1223","url":null,"abstract":"Case Description- A nine years old New Zealand white female diabetic rabbit (blood glucose level~300 mg/dl) was presented to the Department of Veterinary Clinical Complex OPD, Kolkata, India with a history of chronic weight loss along with inappetence, polyuria, haematuria from last 10 days. Feeding history revealed that the animal was maintained with a mixed diet that is rich in calcium (Ca). Clinical Findings- Manual examination revealed moderate pain near the caudal region and a hard mass was felt near the bladder region and a straight lateral radiograph of the abdomen revealed the presence of a radiodense cystolith.Treatment and Outcome- Cystotomy was done and the rabbit was recovered uneventfully. The analysis of the stone revealed calcium carbonate as the major content. Clinical Relevance- The present article describes successful surgical management of urolith in a rabbit and confers ample evidence that a high calcium diet, peculiar Ca metabolism along with more carbohydrate predisposing to diabetes may setup urolithiasis. The present study also emphasizes the fact that diminished Na+-K+-ATPase activity in diabetes can play a pivotal role in the pathogenesis of peripheral vascular and neural complications leading to the development of bladder dysfunction, hence diminished urine flow in diabetic rabbits results in the development of nidus formation and thereby further accumulation of calcium salts in and around nidus leads to the formation of urolithiasis.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44076978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-20DOI: 10.30500/IVSA.2020.243555.1221
Z. Ghorbani, I. Karimi, M. Mahzounieh, Marzieh Faezi, A. Mohamadnia
Objective- Evaluation of possible contamination of sole ulcers with digital dermatitis Treponema spp . Design- Clinical detection Animals- Thirty-three cows with sole ulcer lesion. Procedures- Hoof trimmings were done by professional veterinarian hoof trimmer on a regular basis. Sole ulcer and digital dermatitis recorded as a wounded lesion in zone 4 and 10 of the hooves during hoof trimming and recorded in special sheets. A total of Thirty-three tissue samples from sole ulcers in zone 4 of digits were taken and the 16S rRNA gene was followed by PCR assay. Results- Annual incidence of clinical digital dermatitis recorded as 7.1 percent as the second prevalent digital lesion in the farm following sole ulcer. Treponema spp . was found in 42 percent of the samples, none of the positive samples show concurrent lesion of digital dermatitis and sole ulcer.Conclusion and Clinical Relevance- Since no concurrent lesions were found in sole ulcer samples, finding Treponema spp. in tissues may be a result of the possible pathogenic presence of the bacteria in this region. Multifactorial causes of sole ulcer make different clinical presentations for the lesion and a microbial cause for the sole ulcer that led to non-healing ulcers were reported.
{"title":"Genomic Detection of Bovine Digital Dermatitis Treponemes in Sole Ulcers","authors":"Z. Ghorbani, I. Karimi, M. Mahzounieh, Marzieh Faezi, A. Mohamadnia","doi":"10.30500/IVSA.2020.243555.1221","DOIUrl":"https://doi.org/10.30500/IVSA.2020.243555.1221","url":null,"abstract":"Objective- Evaluation of possible contamination of sole ulcers with digital dermatitis Treponema spp . Design- Clinical detection Animals- Thirty-three cows with sole ulcer lesion. Procedures- Hoof trimmings were done by professional veterinarian hoof trimmer on a regular basis. Sole ulcer and digital dermatitis recorded as a wounded lesion in zone 4 and 10 of the hooves during hoof trimming and recorded in special sheets. A total of Thirty-three tissue samples from sole ulcers in zone 4 of digits were taken and the 16S rRNA gene was followed by PCR assay. Results- Annual incidence of clinical digital dermatitis recorded as 7.1 percent as the second prevalent digital lesion in the farm following sole ulcer. Treponema spp . was found in 42 percent of the samples, none of the positive samples show concurrent lesion of digital dermatitis and sole ulcer.Conclusion and Clinical Relevance- Since no concurrent lesions were found in sole ulcer samples, finding Treponema spp. in tissues may be a result of the possible pathogenic presence of the bacteria in this region. Multifactorial causes of sole ulcer make different clinical presentations for the lesion and a microbial cause for the sole ulcer that led to non-healing ulcers were reported.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43010021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-06DOI: 10.30500/IVSA.2020.231895.1216
R. Vali, Satar Safarpour, Yasaman Daneshvar
Objective- The aim of the present study was to assess the effect of Nigella sativa oil on prostate dimensions in adult dogs. Design- Experimental study Animals- Five adult male dogs Procedures- In this research, 5 adult male Iranian mixed-breed dogs with a mean age of 7.30 ± 2.77 years and a mean weight of 27 ± 5.7 kg with clinical symptoms of prostatitis were selected. Sagittal and transverse ultrasound images were performed by using a 5 MHZ convex transducer. Results- In the obtained images desired parameters such as length, width, and height of the prostate gland were measured before and after administration of Nigella sativa. Results showed significant differences between all measured parameters before and after drug administration (p < 0.05).Conclusion and Clinical Relevance- This study confirms that Nigella sativa oil can reduce prostatic dimensions in adult male dogs. So, it can be used as a safe and effective drug for the treatment of prostate-related diseases such as benign prostatic hyperplasia in dogs.
{"title":"Ultrasonographic Evaluation of the Effect of Nigella sativa Oil on Prostate Dimensions in Adult Iranian Mixed-Breed Dogs","authors":"R. Vali, Satar Safarpour, Yasaman Daneshvar","doi":"10.30500/IVSA.2020.231895.1216","DOIUrl":"https://doi.org/10.30500/IVSA.2020.231895.1216","url":null,"abstract":"Objective- The aim of the present study was to assess the effect of Nigella sativa oil on prostate dimensions in adult dogs. Design- Experimental study Animals- Five adult male dogs Procedures- In this research, 5 adult male Iranian mixed-breed dogs with a mean age of 7.30 ± 2.77 years and a mean weight of 27 ± 5.7 kg with clinical symptoms of prostatitis were selected. Sagittal and transverse ultrasound images were performed by using a 5 MHZ convex transducer. Results- In the obtained images desired parameters such as length, width, and height of the prostate gland were measured before and after administration of Nigella sativa. Results showed significant differences between all measured parameters before and after drug administration (p < 0.05).Conclusion and Clinical Relevance- This study confirms that Nigella sativa oil can reduce prostatic dimensions in adult male dogs. So, it can be used as a safe and effective drug for the treatment of prostate-related diseases such as benign prostatic hyperplasia in dogs.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70077084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-28DOI: 10.30500/IVSA.2020.241541.1220
Mozhgan Malekolkalami, M. Behfar, A. Tehrani
Objective- Leakage after colon anastomosis is the most common complication with the highest mortality rate. Silymarin possesses potent anti-inflammatory, antioxidant, reparative and antibacterial activities and therefore has been used to accelerate different experimental wound healing models. This study was aimed to investigate effects of orally administered silymarin following colonic resection and anastomosis in terms of histopathological and mechanical parameters. Design- An experimental study.Animals- Twenty four male mature Wistar ratsProcedures- The rats were divided randomly into two groups. After aseptic preparation, descending colon was exteriorized thorough laparotomy. Then, colon resection and end to end anastomosis was performed in all rats. The control rats were gavaged with 1 ml normal saline post operatively as placebo while the rats in the treatment group received 50 mg/kg silymarin suspended in 1 ml normal saline for five consecutive days. At the 7th day, all rat were euthanized. Results- Necropsy finding showed that leakage, adhesion formation and peritonitis scores in treatment group were significantly decreased. On histopathology, decreased inflammatory cell infiltration was observed in the treatment group. While, the scores of angiogenesis, cell proliferation, and collagen deposition were significantly increased in the treatment group. No significant difference was observed in bursting pressure when control samples were compared to the silymarin treated ones. Furthermore, mechanical properties (including: maximum load, yield load, and absorbed energy) in treatment group were significantly increased compared to control group. Conclusion and Clinical Relevance- The results of the present study showed that oral administration of silymarin following colonic anastomosis in rats improves the structural indices of wound healing and its mechanical characteristics with lower rates of anastomotic complications.
{"title":"Effect of Short Term Oral Administration of Silymarin on Healing of Colonic Anastomosis in Rats","authors":"Mozhgan Malekolkalami, M. Behfar, A. Tehrani","doi":"10.30500/IVSA.2020.241541.1220","DOIUrl":"https://doi.org/10.30500/IVSA.2020.241541.1220","url":null,"abstract":"Objective- Leakage after colon anastomosis is the most common complication with the highest mortality rate. Silymarin possesses potent anti-inflammatory, antioxidant, reparative and antibacterial activities and therefore has been used to accelerate different experimental wound healing models. This study was aimed to investigate effects of orally administered silymarin following colonic resection and anastomosis in terms of histopathological and mechanical parameters. Design- An experimental study.Animals- Twenty four male mature Wistar ratsProcedures- The rats were divided randomly into two groups. After aseptic preparation, descending colon was exteriorized thorough laparotomy. Then, colon resection and end to end anastomosis was performed in all rats. The control rats were gavaged with 1 ml normal saline post operatively as placebo while the rats in the treatment group received 50 mg/kg silymarin suspended in 1 ml normal saline for five consecutive days. At the 7th day, all rat were euthanized. Results- Necropsy finding showed that leakage, adhesion formation and peritonitis scores in treatment group were significantly decreased. On histopathology, decreased inflammatory cell infiltration was observed in the treatment group. While, the scores of angiogenesis, cell proliferation, and collagen deposition were significantly increased in the treatment group. No significant difference was observed in bursting pressure when control samples were compared to the silymarin treated ones. Furthermore, mechanical properties (including: maximum load, yield load, and absorbed energy) in treatment group were significantly increased compared to control group. Conclusion and Clinical Relevance- The results of the present study showed that oral administration of silymarin following colonic anastomosis in rats improves the structural indices of wound healing and its mechanical characteristics with lower rates of anastomotic complications.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"1 1","pages":"106-114"},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49144703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-28DOI: 10.30500/IVSA.2020.235492.1217
Amin Mohammadi-Rika, M. Beigi-boroujeni, Asghar Rajabzadeh, L. Zarei
Objective- The aim of the present study was to assess the wound-healing activity of extract of Allium stipitatum. Design- Experimental study.Animals- Thirty-six male Wistar diabetic rats.Procedures- The rats weighing approximately 160-180 g and seven weeks of age were randomized into three groups of 12 rats each: Control surgery group (Control) including the creation of wounds and no treatment, base formulation groups positive (POS) with the creation of wounds and application of base formulation ointment, treatment group 1 (T1) with 2 g of powder extract of the plant material in the ointment. A wound was induced by an excisional based wound model in male rats. The mature green leaves of Allium stipitatum were collected and authenticated. Extractions of dried leaves were carried out. For wound-healing activity, the extracts were applied topically in the form of ointment and compared to control groups. The healing of the wound was assessed based on the wound area, histomorphometry, and hydroxyproline estimation studies. Results- Reduction in the wound area and hydroxyproline contents indicated that there was a significant difference (p = 0.001) between group T1 and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was a significant difference between group T1 and other groups (p = 0.001).Conclusions and Clinical Relevance- The extract of Allium stipitatum leaves enhanced wound-healing activity significantly in both the wound models studied. Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content, improved histological characteristics studies suggested Allium stipitatum leaves extract might have therapeutic benefits in wound healing.
{"title":"Effect of Extract of Allium stipitatum on Excisional Wound Healing in Rats","authors":"Amin Mohammadi-Rika, M. Beigi-boroujeni, Asghar Rajabzadeh, L. Zarei","doi":"10.30500/IVSA.2020.235492.1217","DOIUrl":"https://doi.org/10.30500/IVSA.2020.235492.1217","url":null,"abstract":"Objective- The aim of the present study was to assess the wound-healing activity of extract of Allium stipitatum. Design- Experimental study.Animals- Thirty-six male Wistar diabetic rats.Procedures- The rats weighing approximately 160-180 g and seven weeks of age were randomized into three groups of 12 rats each: Control surgery group (Control) including the creation of wounds and no treatment, base formulation groups positive (POS) with the creation of wounds and application of base formulation ointment, treatment group 1 (T1) with 2 g of powder extract of the plant material in the ointment. A wound was induced by an excisional based wound model in male rats. The mature green leaves of Allium stipitatum were collected and authenticated. Extractions of dried leaves were carried out. For wound-healing activity, the extracts were applied topically in the form of ointment and compared to control groups. The healing of the wound was assessed based on the wound area, histomorphometry, and hydroxyproline estimation studies. Results- Reduction in the wound area and hydroxyproline contents indicated that there was a significant difference (p = 0.001) between group T1 and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was a significant difference between group T1 and other groups (p = 0.001).Conclusions and Clinical Relevance- The extract of Allium stipitatum leaves enhanced wound-healing activity significantly in both the wound models studied. Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content, improved histological characteristics studies suggested Allium stipitatum leaves extract might have therapeutic benefits in wound healing.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43015618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-21DOI: 10.30500/IVSA.2020.244439.1222
Khosro Safari, A. Raisi, A. Zakian, A. Mohamadnia
Objective- This practice performed to compare the quality of analgesia, hematological parameters, and prevalence of cardiac dysrhythmias following epidural administration of lidocaine, lidocaine-meloxicam, and lidocaine-Metamizole sodium in cows. Animals- Fifteen adult Holstein cows aged between 3-5 years were assigned into three equal groups. Design- Each cow received the lidocaine (0.22 mg/kg), lidocaine-meloxicam (0.11 mg/kg – 0.25 mg/kg) or lidocaine-Metamizole sodium (0.11 mg/kg -4 mg/kg) randomly via epidural injection into first intercoccygeal space. Procedure- Analgesia onset and duration were recorded. Heart rate, respiratory rate, rectal temperature, and ruminal motility were also recorded at 0, 5, 15, 30, 45, 60, 90 and 120 minutes, Electrocardiograms at 0, 60 and 120 minutes and blood samples were collected through the caudal vein at 0, 30, 60, 90 and 120 minutes. Detection of arrhythmias was done by checking 60 seconds of each electrocardiogram.Results- analgesia onset in lidocaine-metamizole treatment was significantly longer than that of the other groups (p 0.05). Also, the duration of analgesia was significantly longer in lidocaine treatment compared to other experimental groups (p 0.05). Hematological parameters changes were not significantly different and all of the detected cardiac arrhythmias were physiologic among treatments (p > 0.05). Conclusions and Clinical Relevance- Aforementioned dosages could be used in cows without any clinical, cardiac, and hematological side effects. Lidocaine analgesia was reliable; however, the authors were not sure about adequate analgesia resulted after injection the half-dose of meloxicam and Metamizole in combination with lidocaine therefore, further studies should be done.
{"title":"Comparison of the Effect of Lidocaine in Combination to Meloxicam and/or Metamizole Sodium Epidurally on Analgesic Parameters, and Health Status of Holstein Cattle","authors":"Khosro Safari, A. Raisi, A. Zakian, A. Mohamadnia","doi":"10.30500/IVSA.2020.244439.1222","DOIUrl":"https://doi.org/10.30500/IVSA.2020.244439.1222","url":null,"abstract":"Objective- This practice performed to compare the quality of analgesia, hematological parameters, and prevalence of cardiac dysrhythmias following epidural administration of lidocaine, lidocaine-meloxicam, and lidocaine-Metamizole sodium in cows. Animals- Fifteen adult Holstein cows aged between 3-5 years were assigned into three equal groups. Design- Each cow received the lidocaine (0.22 mg/kg), lidocaine-meloxicam (0.11 mg/kg – 0.25 mg/kg) or lidocaine-Metamizole sodium (0.11 mg/kg -4 mg/kg) randomly via epidural injection into first intercoccygeal space. Procedure- Analgesia onset and duration were recorded. Heart rate, respiratory rate, rectal temperature, and ruminal motility were also recorded at 0, 5, 15, 30, 45, 60, 90 and 120 minutes, Electrocardiograms at 0, 60 and 120 minutes and blood samples were collected through the caudal vein at 0, 30, 60, 90 and 120 minutes. Detection of arrhythmias was done by checking 60 seconds of each electrocardiogram.Results- analgesia onset in lidocaine-metamizole treatment was significantly longer than that of the other groups (p 0.05). Also, the duration of analgesia was significantly longer in lidocaine treatment compared to other experimental groups (p 0.05). Hematological parameters changes were not significantly different and all of the detected cardiac arrhythmias were physiologic among treatments (p > 0.05). \u0000Conclusions and Clinical Relevance- Aforementioned dosages could be used in cows without any clinical, cardiac, and hematological side effects. Lidocaine analgesia was reliable; however, the authors were not sure about adequate analgesia resulted after injection the half-dose of meloxicam and Metamizole in combination with lidocaine therefore, further studies should be done.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"123-132"},"PeriodicalIF":0.0,"publicationDate":"2020-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46142822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-08-06DOI: 10.30500/IVSA.2020.225832.1213
M. Javdani, A. Hashemi, A. Bigham-Sadegh, Z. Nikousefat
Objective- The aim of this study was to evaluate etomidate as an injectable anesthetic in dogs and to use midazolam and methocarbamol in premedication.Design- Experimental Study.Animals- Fourteen native young female dogsProcedure- Dogs were randomly allocated to one of two groups to receive: midazolam (0.5 mg/kg; MiE group) or methocarbamol (20 mg/kg; MeE group) 5 minutes before etomidate (2 mg/kg) administered intravenously. In addition to recording anesthesia plan times, some physiological and hematobiochemical parameters were also measured at different times in the two groups. Results- It was found that there was no significant difference between the two groups at both induction and recovery time. Heart rate, respiratire rate, and rectal temperature changes in the MiE group were noticeably fluctuating, unlike the MeE group. There was a significant difference in the values of hematocrit, total protein, glucose, and cortisol between the two groups at some times. Significant increase in ALT and AST activity was observed in MeE group compared to MiE group at some times.Conclusion and clinical relevance- Intramuscular administration of methocarbamol such as midazolam prior to induction of anesthesia by etomidate in dogs, while providing similar anesthesia and recovery time, has minimal cardiopulmonary effects and hematobiochemical changes in dogs under anesthesia.
{"title":"Evaluation of Etomidate as an Intravenous Anesthetic Drug in Dogs: Using Midazolam and Methocarbamol in Premedication","authors":"M. Javdani, A. Hashemi, A. Bigham-Sadegh, Z. Nikousefat","doi":"10.30500/IVSA.2020.225832.1213","DOIUrl":"https://doi.org/10.30500/IVSA.2020.225832.1213","url":null,"abstract":"Objective- The aim of this study was to evaluate etomidate as an injectable anesthetic in dogs and to use midazolam and methocarbamol in premedication.Design- Experimental Study.Animals- Fourteen native young female dogsProcedure- Dogs were randomly allocated to one of two groups to receive: midazolam (0.5 mg/kg; MiE group) or methocarbamol (20 mg/kg; MeE group) 5 minutes before etomidate (2 mg/kg) administered intravenously. In addition to recording anesthesia plan times, some physiological and hematobiochemical parameters were also measured at different times in the two groups. Results- It was found that there was no significant difference between the two groups at both induction and recovery time. Heart rate, respiratire rate, and rectal temperature changes in the MiE group were noticeably fluctuating, unlike the MeE group. There was a significant difference in the values of hematocrit, total protein, glucose, and cortisol between the two groups at some times. Significant increase in ALT and AST activity was observed in MeE group compared to MiE group at some times.Conclusion and clinical relevance- Intramuscular administration of methocarbamol such as midazolam prior to induction of anesthesia by etomidate in dogs, while providing similar anesthesia and recovery time, has minimal cardiopulmonary effects and hematobiochemical changes in dogs under anesthesia.","PeriodicalId":14554,"journal":{"name":"Iranian Journal of Veterinary Surgery","volume":"15 1","pages":"96-105"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49024885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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