M. Sakhaie, Atefeh Mohammad-Hosseini, M. Sadegh, B. Khansarinejad, S. Babaei
Methods: Sixty male Wistar rats were divided into five groups of 12 each. Group 1 received normal saline while Group 2 received a single dose of TMT (8 mg/kg). The other four groups received TMT at 8 mg/kg plus 60, 100 or 120 mg/kg PTX twice daily for six consecutive days. The rats’ working and reference memory were investigated, using radial arm maze tasks. At the end of the experiments, the rats’ brains were removed and processed for histological study of the hippocampus.
{"title":"Pentoxifylline Protects Against Hippocampal Damage and Memory Impairment Induced by Trimethyltin","authors":"M. Sakhaie, Atefeh Mohammad-Hosseini, M. Sadegh, B. Khansarinejad, S. Babaei","doi":"10.32598/IJT.15.2.738.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.738.1","url":null,"abstract":"Methods: Sixty male Wistar rats were divided into five groups of 12 each. Group 1 received normal saline while Group 2 received a single dose of TMT (8 mg/kg). The other four groups received TMT at 8 mg/kg plus 60, 100 or 120 mg/kg PTX twice daily for six consecutive days. The rats’ working and reference memory were investigated, using radial arm maze tasks. At the end of the experiments, the rats’ brains were removed and processed for histological study of the hippocampus.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"83-90"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48632411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reza Tajik, A. Alimoradian, M. Jamalian, M. Shamsi, Rahmatolah Moradzadeh, Behnoosh Ansari Asl, Mohaddeseh Asafari
Article info: Received: 20 Dec 2020 Accepted: 09 Mar 2021 Online Published: 01 Apr 2021 Research Paper: Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran * Corresponding author: Mohaddeseh Asafari, MSc. Address: Deputy of Food and Drug, Arak University of Medical Sciences, Arak, Iran. E-mail: m.asafari@arakmu.ac.ir
{"title":"Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran","authors":"Reza Tajik, A. Alimoradian, M. Jamalian, M. Shamsi, Rahmatolah Moradzadeh, Behnoosh Ansari Asl, Mohaddeseh Asafari","doi":"10.32598/IJT.15.2.784.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.784.1","url":null,"abstract":"Article info: Received: 20 Dec 2020 Accepted: 09 Mar 2021 Online Published: 01 Apr 2021 Research Paper: Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran * Corresponding author: Mohaddeseh Asafari, MSc. Address: Deputy of Food and Drug, Arak University of Medical Sciences, Arak, Iran. E-mail: m.asafari@arakmu.ac.ir","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44620503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methods: 0.1 mL heparinized 0.2 mL peripheral blood taken from a healthy male and a female were plated in culture media under sterile conditions. To prepare the reference dose at a concentration of 0.05 mg/mL, 0.027g BPA was dissolved in 1 L dimethyl sulfoxide and the highest dose of 50 μg/mL BPA solution was prepared. After separating the stock solution, 50 μg/mL BPA was diluted to prepare 20, 10 or 5 μg/mL doses.
{"title":"Cytotoxic Effects of Bisphenol A as an Endocrine Disruptor on Human Lymphocytes","authors":"M. Özgür, Ş. Yılmaz, Ash Uçar, S. Yılmaz","doi":"10.32598/IJT.15.2.753.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.753.1","url":null,"abstract":"Methods: 0.1 mL heparinized 0.2 mL peripheral blood taken from a healthy male and a female were plated in culture media under sterile conditions. To prepare the reference dose at a concentration of 0.05 mg/mL, 0.027g BPA was dissolved in 1 L dimethyl sulfoxide and the highest dose of 50 μg/mL BPA solution was prepared. After separating the stock solution, 50 μg/mL BPA was diluted to prepare 20, 10 or 5 μg/mL doses.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"115-120"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45841852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Touraj, A. Ahmadi, Mona Pazhouhi, C. Jalili, K. Rezaei
1. Department of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran. 3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. 4. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
{"title":"Effects of Exposure to Aflatoxin G1 on the Plasma Biochemical Factors and Histopathological Properties of Renal Tissue in Mice","authors":"Touraj, A. Ahmadi, Mona Pazhouhi, C. Jalili, K. Rezaei","doi":"10.32598/IJT.15.2.787.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.787.1","url":null,"abstract":"1. Department of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran. 3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. 4. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"127-134"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46108550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gholami-Ahangaran, A. Ahmadi-Dastgerdi, S. Azizi
Results: The mean contents of cadmium in the chicken thigh, breast, liver and heart samples were 0.055±0.021, 0.048±0.023, 0.074±0.031, and 0.012±0.004 mg/kg, respectively. The mean contents of zinc in the chicken thigh, breast, liver and heart samples were 17.19±8.10, 15.70±5.75, 22.10±10.87, and 19.70±10.38 mg/kg, respectively. The concentrations of cadmium and zinc were below the international permissible limits in all samples. The mean concentrations of silver in some chicken thigh, breast, liver and heart samples were 0.0080±0.0044, 0.0048±0.0013, 0.012±0.009 and 0.0036±0.006, respectively. Of note, silver was not detected in most chicken samples.
{"title":"The Measurement of Cadmium, Zinc and Silver in Chicken Meat in Isfahan Province, Iran","authors":"M. Gholami-Ahangaran, A. Ahmadi-Dastgerdi, S. Azizi","doi":"10.32598/IJT.15.2.434.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.434.1","url":null,"abstract":"Results: The mean contents of cadmium in the chicken thigh, breast, liver and heart samples were 0.055±0.021, 0.048±0.023, 0.074±0.031, and 0.012±0.004 mg/kg, respectively. The mean contents of zinc in the chicken thigh, breast, liver and heart samples were 17.19±8.10, 15.70±5.75, 22.10±10.87, and 19.70±10.38 mg/kg, respectively. The concentrations of cadmium and zinc were below the international permissible limits in all samples. The mean concentrations of silver in some chicken thigh, breast, liver and heart samples were 0.0080±0.0044, 0.0048±0.0013, 0.012±0.009 and 0.0036±0.006, respectively. Of note, silver was not detected in most chicken samples.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43029809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Najafi, M. Hashemzaei, M. Sadeghi, Sajedeh Seyed Mousavi, A. Bazi, Sahar Fanoudi, M. Belaran, Hanieh Rezaei, Hamideh Arezoomandan, H. Mirzaei, K. Tabrizian
1. Department of Pharmaceutical Care, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 3. Students Research Committee, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 4. Department of Hematology, Faculty of Allied Health Sciences, Zabol University of Medical Sciences, Zabol, Iran. 5. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Department of Physiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 7. Department of Biotechnology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 8. Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran. 9. Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran.
{"title":"The Protective Effects of Nicotine and Bucladesine on Impaired Avoidance Memory Caused by Sodium Arsenate Toxicity in Mice","authors":"S. Najafi, M. Hashemzaei, M. Sadeghi, Sajedeh Seyed Mousavi, A. Bazi, Sahar Fanoudi, M. Belaran, Hanieh Rezaei, Hamideh Arezoomandan, H. Mirzaei, K. Tabrizian","doi":"10.32598/IJT.15.2.772.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.772.1","url":null,"abstract":"1. Department of Pharmaceutical Care, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 3. Students Research Committee, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 4. Department of Hematology, Faculty of Allied Health Sciences, Zabol University of Medical Sciences, Zabol, Iran. 5. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Department of Physiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 7. Department of Biotechnology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 8. Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran. 9. Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44864499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amin Sharifan, M. Etebari, B. Zolfaghari, M. Aliomrani
Methods: Using the maceration technique, we obtained the ethanolic extract of Pinus eldarica’s bark (BHAEPE). Folin-ciocalteu reagent was used to determine the total phenolic content of BHAEPE. The Needle’s Volatile Oil of Pinus eldarica (NVOPE) was obtained by Clevenger hydrodistillation method. The main components of NVOPE were identified by Gas Chromatography and Mass Spectrophotometry (GC-MS). We used DPPH assay to investigate the antioxidant activity of both NVOPE and BHAEPE. Also, MTT assay was performed to test the protective effects of both BHAEPE and NVOPE against cisplatin.
{"title":"Antioxidant Effects of Pinus eldarica Extracts Against Cisplatin-induced Cytotoxicity in Human Hepatoma (HepG2) Cell Line","authors":"Amin Sharifan, M. Etebari, B. Zolfaghari, M. Aliomrani","doi":"10.32598/IJT.15.2.764.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.764.1","url":null,"abstract":"Methods: Using the maceration technique, we obtained the ethanolic extract of Pinus eldarica’s bark (BHAEPE). Folin-ciocalteu reagent was used to determine the total phenolic content of BHAEPE. The Needle’s Volatile Oil of Pinus eldarica (NVOPE) was obtained by Clevenger hydrodistillation method. The main components of NVOPE were identified by Gas Chromatography and Mass Spectrophotometry (GC-MS). We used DPPH assay to investigate the antioxidant activity of both NVOPE and BHAEPE. Also, MTT assay was performed to test the protective effects of both BHAEPE and NVOPE against cisplatin.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"91-98"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42287137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhenaz Hatefi Kia, Sakineh Kazemi Noureini, M. R. Vaezi Kakhki
Methods: The root, aerial parts and flowers of the plant were, collected and dried separately at ambient temperature and away from direct sunlight. The aquatic and methanolic extracts of each part was prepared. The effect of each extract on the growth of MCF-7 breast carcinoma cells and HEK293 normal cell line was evaluated, using MTT assay. Each experiment was repeated at least three times independently. The IC50 values for each treatment time point were analyzed, using ANOVA at P<0.05.
{"title":"The Extracts of Epilobium Parviflorum Inhibit MCF-7 Breast Cancer Cells","authors":"Bhenaz Hatefi Kia, Sakineh Kazemi Noureini, M. R. Vaezi Kakhki","doi":"10.32598/IJT.15.1.752.1","DOIUrl":"https://doi.org/10.32598/IJT.15.1.752.1","url":null,"abstract":"Methods: The root, aerial parts and flowers of the plant were, collected and dried separately at ambient temperature and away from direct sunlight. The aquatic and methanolic extracts of each part was prepared. The effect of each extract on the growth of MCF-7 breast carcinoma cells and HEK293 normal cell line was evaluated, using MTT assay. Each experiment was repeated at least three times independently. The IC50 values for each treatment time point were analyzed, using ANOVA at P<0.05.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41803061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
1. Department of Nursing, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. 2. Department of Biology, Cellular and Molecular Research Center, Shiraz University, Shiraz, Iran. 3. Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. 4. Cellular and Molecular Research Center, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.
{"title":"Preserved Ovarian Function Following Toxicity With Doxorubicin in Rats: Protective Effect of Nasturtium Officinale Extract","authors":"P. Rad, F. Safari, J. Mohammadi, H. Delaviz","doi":"10.32598/IJT.15.1.747.1","DOIUrl":"https://doi.org/10.32598/IJT.15.1.747.1","url":null,"abstract":"1. Department of Nursing, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. 2. Department of Biology, Cellular and Molecular Research Center, Shiraz University, Shiraz, Iran. 3. Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. 4. Cellular and Molecular Research Center, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":" ","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42147243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Article info: Received: 16 Jul 2020 Accepted: 20 Sep 2020 Online Published: 01 Jan 2021 Research Paper: Toxicological Assessment of Solanum Erianthum Extracts in Albino Rats: Haematological, Biochemical and Histopathological Findings * Corresponding author: Ikechukwu Peter Ejidike, PhD. Address: Department of Chemical Sciences, Faculty of Science and Science Education, Anchor University, Ayobo, Lagos, Nigeria. E-mail: iejidike@aul.edu.ng
文章信息:收稿日期:2020年7月16日接收日期:2020年9月20日在线发布日期:2021年1月01日研究论文:白化病大鼠的毒理学评价:血液学、生化和组织病理学结果*通讯作者:Ikechukwu Peter Ejidike, PhD。地址:尼日利亚拉各斯阿约博Anchor大学科学与科学教育学院化学科学系。电子邮件:iejidike@aul.edu.ng
{"title":"Toxicological Assessment of Solanum Erianthum Extracts in Albino Rats: Haematological, Biochemical and Histopathological Findings","authors":"Ngozi Maureen Uzoekwe, I. Ejidike, M. Ukhun","doi":"10.32598/IJT.15.1.728.1","DOIUrl":"https://doi.org/10.32598/IJT.15.1.728.1","url":null,"abstract":"Article info: Received: 16 Jul 2020 Accepted: 20 Sep 2020 Online Published: 01 Jan 2021 Research Paper: Toxicological Assessment of Solanum Erianthum Extracts in Albino Rats: Haematological, Biochemical and Histopathological Findings * Corresponding author: Ikechukwu Peter Ejidike, PhD. Address: Department of Chemical Sciences, Faculty of Science and Science Education, Anchor University, Ayobo, Lagos, Nigeria. E-mail: iejidike@aul.edu.ng","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"37-48"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69706644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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