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Impact of CrossFit Training Programs on the Physical Health and Sociogenic Somatic Anxiety of Adolescents CrossFit 训练计划对青少年身体健康和社会性躯体焦虑的影响
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-17 DOI: 10.18502/ijph.v53i7.16053
Zhiqin Zhang, Renwei Yang, Gang Sun, Yong Wang
Background: A decline in adolescent health holds significant repercussions for public health. Promoting exercise is essential to improve physical and mental health among youth. This study aimed to explore the effect of CrossFit training programs on the physical health and sociogenic somatic anxiety of adolescents. Methods: In March 2023, 100 adolescents were openly recruited from eight middle schools in Jinhua, China. The participants, were divided equally into control and experimental groups, experienced either traditional or CrossFit training, respectively, over nine weeks. Evaluation measures included the analysis of social physique anxiety, body esteem, physical self-efficacy, and general physical health before and after the exercise program. Results: Post-intervention data demonstrated marked reductions across all facets of the social physique anxiety scale, including worries about public scrutiny, anxiety from social comparison, and discomfort related to one’s physical self-image, more so in the experimental group (P<0.05). Likewise, assessments of the physical self-perception profile and physical self-efficacy scale were enhanced, again with the experimental cohort displaying more pronounced improvements (P<0.05). Results from biophysical function evaluations indicated significant health improvements post-intervention, with noted advancements in lung capacity, aerobic fitness by the standing long jump, and muscular endurance as assessed by grip strength, sit-up, and push-up counts, primarily in the experimental group (P<0.05). Conclusion: CrossFit training offered considerable advantages by reducing social physique anxiety and enhancing adolescents’ body esteem and physical self-efficacy. The program stimulated improvements in body composition, cardiorespiratory fitness, muscle strength, and flexibility.  
背景:青少年健康状况的下降会对公共卫生产生重大影响。促进锻炼对改善青少年的身心健康至关重要。本研究旨在探讨 CrossFit 训练计划对青少年身体健康和社会性躯体焦虑的影响。研究方法2023年3月,在金华市8所中学公开招募100名青少年。参与者被平均分为对照组和实验组,分别接受为期九周的传统或CrossFit训练。评估指标包括运动前后的社交体质焦虑、身体自尊、身体自我效能感和一般身体健康分析。结果显示干预后的数据显示,社交体质焦虑量表的所有方面都有明显下降,包括对公众审视的担忧、来自社会比较的焦虑以及与个人身体自我形象相关的不适感,实验组的下降幅度更大(P<0.05)。同样,体能自我感觉量表和体能自我效能量表的评估结果也有所提高,实验组的提高幅度更大(P<0.05)。生物物理功能评估结果表明,干预后,实验组的健康状况明显改善,肺活量、通过立定跳远评估的有氧体能以及通过握力、仰卧起坐和俯卧撑次数评估的肌肉耐力均有显著提高(P<0.05)。结论CrossFit 训练通过减少社交体质焦虑、增强青少年的身体自尊和身体自我效能感,为青少年提供了相当大的优势。该计划可促进身体成分、心肺功能、肌肉力量和柔韧性的改善。
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引用次数: 0
Association between the Dietary Inflammatory Index and the Risk of Cesarean Delivery 膳食炎症指数与剖腹产风险之间的关系
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-17 DOI: 10.18502/ijph.v53i7.16056
Fateme Sheikholmolooki, A. Djazayery, B. Abbasi
Background: Cesarean section (CS) is one of the most important pregnancy concerns in the world. Increased inflammation is associated with increased risk factors for cesarean section. Diet plays a major role in reducing inflammation. This study aimed to investigate the relationship between dietary inflammatory index (DII) and the risk of Cesarean section in Tehranian women. Methods: This case-control study included 390 pregnant women in Tehran, Iran between 2020 and 2021 at their initial visit to pregnancy clinics, selected by a cluster sampling method. Dietary intakes were determined using valid reliable questionnaires and DII was calculated. Weight, height, and waist circumference were also measured. Results: The mean age of the subjects was 28.5 yr (± 5.02) and weight, body mass index (BMI) and waist circumference (WC) in the case group with a higher DII were higher. Odds ratio (OR) of cesarean section in DII quartiles was statistically significant. Confounding factors including age, BMI and total energy intake were adjusted in the first model and weight, waist circumference, physical activity and supplements in the second model and the relationship remained significant (P<0.001). Conclusion: High scores of dietary inflammatory index, possibly through an increase in inflammatory factors, can increase the chances of having a cesarean section.
背景:剖宫产(CS)是世界上最重要的妊娠问题之一。炎症的增加与剖腹产风险因素的增加有关。饮食在减少炎症方面发挥着重要作用。本研究旨在调查膳食炎症指数(DII)与德黑兰妇女剖宫产风险之间的关系。研究方法这项病例对照研究纳入了 390 名 2020 年至 2021 年期间在伊朗德黑兰妊娠诊所初诊的孕妇,她们是通过聚类抽样法选出的。使用有效可靠的调查问卷确定膳食摄入量,并计算 DII。此外,还测量了体重、身高和腰围。结果受试者的平均年龄为 28.5 岁(± 5.02),DII 较高的病例组的体重、体重指数(BMI)和腰围(WC)均较高。在 DII 四分位数中,剖宫产的比值比(OR)具有统计学意义。在第一个模型中调整了包括年龄、体重指数和总能量摄入量在内的干扰因素,在第二个模型中调整了体重、腰围、体力活动和补充剂,结果两者之间的关系仍然显著(P<0.001)。结论膳食炎症指数得分高,可能会增加炎症因子,从而增加剖腹产的几率。
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引用次数: 0
Investigating the Correlation between Handedness and Emotion Regulation Strategies in Asthma and Allergy Patients 调查哮喘和过敏症患者的手感与情绪调节策略之间的相关性
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-17 DOI: 10.18502/ijph.v53i7.16059
M. Shahandeh, K. Shahandeh, Marjan Shiralian
Background: Asthma and allergic diseases are common chronic non-communicable conditions that can negatively impact the quality of life of patients. Psychological factors play a role in both the onset and progression of these conditions. The purpose of this study was to examine the relationship between handedness and emotion regulation and cognitive emotion regulation strategies in patients with asthma and allergies in Isfahan, central Iran. Methods: We employed a causal-comparative research design. The study population consisted of all patients visiting Asthma and Allergy Clinic in Isfahan. One hundred participants were selected through probability sampling. Data were collected using the Emotion Regulation Questionnaire and the Cognitive Emotion Regulation Strategies Questionnaire, and were analyzed using univariate analysis of variance (ANOVA). Results: Cognitive emotion regulation was significantly different between right-handed and left-handed patients with asthma and allergies (P=0.0001). A significant difference was also observed between the two groups in their emotion regulation strategies (P=0.031). The rate of positive and negative cognitive regulation strategies was higher in left-handed individuals with asthma and allergies, compared to right-handed individuals. Conclusion: Overall, handedness has a significant impact on the behavior and mental health of patients suffering from asthma and allergies. Therefore, handedness should be taken into consideration in interventions for emotion regulation.
背景:哮喘和过敏性疾病是常见的慢性非传染性疾病,会对患者的生活质量产生负面影响。心理因素在这些疾病的发病和发展过程中都扮演着重要角色。本研究旨在探讨伊朗中部伊斯法罕哮喘和过敏症患者的手性与情绪调节和认知情绪调节策略之间的关系。研究方法我们采用了因果比较研究设计。研究对象包括在伊斯法罕哮喘和过敏诊所就诊的所有患者。通过概率抽样选出了 100 名参与者。使用情绪调节问卷和认知情绪调节策略问卷收集数据,并使用单变量方差分析(ANOVA)进行分析。结果显示左撇子和右撇子哮喘和过敏症患者的认知情绪调节能力有显著差异(P=0.0001)。两组患者的情绪调节策略也存在明显差异(P=0.031)。与惯用右手者相比,哮喘和过敏症左撇子患者采用积极和消极认知调节策略的比例更高。结论总体而言,惯用手对哮喘和过敏症患者的行为和心理健康有显著影响。因此,在干预情绪调节时应考虑到惯用手的问题。
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引用次数: 0
Association between Neck Circumference and Asymptomatic Hyperuricemia in Nearly Healthy Adults: A Review of 2019-2020 Cross-Sectional Korean Nationwide Data 颈围与近乎健康成年人无症状高尿酸血症之间的关系:2019-2020年韩国全国横断面数据回顾
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-17 DOI: 10.18502/ijph.v53i7.16062
In Cheol Hwang, H. Suh, Hong Yup Ahn, Mi Ryoung Seo, J. Yeo
Background: Neck circumference (NC) measurement has been recently developed as a simple and time-saving anthropometric method for predicting cardiovascular risk. Asymptomatic hyperuricemia is known as one of the cardiovascular risk factors. This study investigated the association between NC and asymptomatic hyperuricemia among the general population of Korea. Methods: This cross-sectional study examined data from 7,629 participants in the 2019–2020 Korea National Health and Nutrition Examination Survey. Multivariable logistic regression analysis was used to identify the factors associated with hyperuricemia. Results: Approximately 10% of participants corresponded to hyperuricemia group who were likely to be male, have more comorbidities, poorer habits, and larger NC. Multivariable regression analysis revealed that NC was significantly associated with hyperuricemia in women (OR 1.17; 95% CI 1.06-1.30), but not in men (OR 1.04; 95% CI 0.96-1.12). Conclusion: A large NC is independently correlated with hyperuricemia among Korean women.  
背景:颈围(NC)测量是最近发展起来的一种预测心血管风险的简单、省时的人体测量方法。众所周知,无症状高尿酸血症是心血管风险因素之一。本研究调查了韩国普通人群中颈围与无症状高尿酸血症之间的关系。研究方法这项横断面研究研究了 2019-2020 年韩国国民健康与营养调查中 7629 名参与者的数据。采用多变量逻辑回归分析来确定与高尿酸血症相关的因素。结果显示约10%的参与者属于高尿酸血症组,他们可能是男性、合并症较多、生活习惯较差和NC较大。多变量回归分析显示,女性的 NC 与高尿酸血症有显著相关性(OR 1.17;95% CI 1.06-1.30),但男性的 NC 与高尿酸血症无显著相关性(OR 1.04;95% CI 0.96-1.12)。结论在韩国女性中,NC过大与高尿酸血症有独立的相关性。
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引用次数: 0
Impact of Psychological Capital on Organizational Commitment and Turnover Intention: Evidence from Korean Flight Attend-ants 心理资本对组织承诺和离职意向的影响:来自韩国空乘人员的证据
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-14 DOI: 10.18502/ijph.v53i7.16052
Eui-Jin Han, Lei Cai
Background: We analyzed the effects of psychological capital on organizational commitment and turnover intention among flight attendants at a Korean airline and the mediating effect of organizational commitment. Methods: Data were collected through a 2022 survey of Korean flight attendants, yielding 297 responses. Model reliability and validity were assessed to confirm hypotheses. Results: Hope had a significant negative effect on turnover intention P<0.05), whereas optimism and resilience did not have significant effects on turnover intention. Additionally, hope had a significant positive effect on normative and continuance commitment, unlike optimism and resilience, which did not have significant effects on normative commitment or continuance commitment. Both normative commitment and continuance commitment negatively influenced turnover intention. Organizational commitment mediated the relationship between psychological capital and turnover intention, reinforcing the positive impact of psychological capital on reducing turnover intention. Conclusion: This study underscores the significance of psychological capital in shaping organizational commitment and reducing turnover intention among Korean flight attendants. Strengthening psychological capital and fostering organizational commitment can bolster airline stability, competitiveness, and service quality.
研究背景我们分析了心理资本对韩国某航空公司空乘人员组织承诺和离职意向的影响,以及组织承诺的中介效应。研究方法通过对 2022 名韩国空乘人员进行调查收集数据,共收到 297 份回复。评估模型的信度和效度,以确认假设。结果:希望对离职率有显著的负面影响:希望对离职意向有显著的负向影响(P<0.05),而乐观和复原力对离职意向没有显著影响。此外,希望对规范承诺和持续承诺有显著的正向影响,而乐观和复原力则不同,它们对规范承诺和持续承诺没有显著影响。规范性承诺和持续性承诺对离职意向都有负面影响。组织承诺对心理资本和离职意向之间的关系起到了中介作用,加强了心理资本对降低离职意向的积极影响。结论本研究强调了心理资本对韩国空乘人员形成组织承诺和降低离职意向的重要意义。加强心理资本和促进组织承诺可以提高航空公司的稳定性、竞争力和服务质量。
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引用次数: 0
Environmental Health Risk of Microplastics Due to Consumption of Fish and Shellfish in the Coastal Area 在沿海地区食用鱼类和贝类造成的微塑料环境健康风险
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-13 DOI: 10.18502/ijph.v53i7.16049
A. Daud, Hasanuddin Ishak, Erniwati Ibrahim, Basir Basir, A. Birawida, Rizky Chaeraty Syam, Andi Imam Arundana, Abdul Gafur
Background: The increasing accumulation of plastic waste is the most serious threat to the marine ecosystem. People who still have the habit of disposing of solid waste, especially plastic-type waste, in the marine environment have led to the discovery of microplastic content in various marine biota such as fish and shellfish. We aimed to assess the environmental health risks of microplastics due to consumption of marine life in the coastal area. Methods: We used an observational method with the Environmental Health Risk Assessment (EHRA) design to analyze the health risks of humans consuming fish and shellfish containing microplastics. This research was conducted in the coastal area of ​​Takalar Regency, Indonesia in 2022. The samples used consisted of human (n = 30) and marine biota (fish, n=20; shellfish, n=20) samples. The data were obtained from observations, physical measurements of biota, laboratory tests, polymer type identification by Fourier Transform Infrared (FTIR) spectroscopy, and microscopy. Results: The average concentration of microplastics containing styrene compounds in shellfish was 2.01 mg/kg. The abundance of MPs in the fish and shellfish samples was 0.01 particles/g or 10 particles/kg in fish and 7 particles/individual in shellfish. The MPs were found in line, fragment, film, and pellet forms, with different size and color variations. The average MPs exposure risk level (RQ value) for both fish and shellfish was 0.02. Conclusion: All samples had RQ values < 1, which means that the microplastic-containing tofu shellfish were still safe for consumption by people living in the Takalar coastal area.
背景:塑料废物的日益积累是对海洋生态系统最严重的威胁。由于人们仍有在海洋环境中丢弃固体废物(尤其是塑料类废物)的习惯,因此在鱼类和贝类等各种海洋生物群中发现了微塑料成分。我们的目的是评估沿海地区海洋生物食用微塑料对环境健康造成的风险。方法:我们采用环境健康风险评估(EHRA)设计的观察法,分析人类食用含有微塑料的鱼类和贝类的健康风险。这项研究于 2022 年在印度尼西亚塔卡拉尔县沿海地区进行。所用样本包括人体样本(n = 30)和海洋生物群样本(鱼类,n = 20;贝类,n = 20)。数据来自观察、生物群的物理测量、实验室测试、傅立叶变换红外光谱(FTIR)聚合物类型鉴定和显微镜检查。研究结果贝类中含有苯乙烯化合物的微塑料平均浓度为 2.01 毫克/千克。鱼类和贝类样本中的 MPs 丰度分别为 0.01 颗粒/克或 10 颗粒/千克(鱼类)和 7 颗粒/个(贝类)。多氯联苯以线状、碎片状、薄膜状和颗粒状存在,大小和颜色各不相同。鱼类和贝类接触 MPs 的平均风险水平(RQ 值)为 0.02。结论所有样本的 RQ 值均小于 1,这意味着生活在 Takalar 沿海地区的人们仍可放心食用含有微塑料的豆腐贝类。
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引用次数: 0
Diabetes Mellitus Inequality in South Korean Adults by Region: The Influence of Obesity and Depression 按地区划分的韩国成年人糖尿病不平等现象:肥胖和抑郁的影响
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-13 DOI: 10.18502/ijph.v53i7.16045
Seong-Hi Park, Heashoon Lee
Background: Diabetes mellitus (DM) has different prevalence by region. This study aimed to identify the differences in the effects of obesity and depression on DM in South Korean adults by region. Methods: The participants were 14,343 adults (≥30 yr) from Ulsan (regions with the lowest prevalence of DM) and Jeonbuk (regions with the highest prevalence of DM), and data were extracted from the Community Health Survey 2019. We applied a complex sampling design analysis to reflect the stratified, clustering and weights. The data were analyzed using the unweighted frequencies, weighted percentage, mean, standard error, Chi-Square test and multiple logistic regression analysis (SPSS 25.0). Results: Regarding the main result for Ulsan, the odds ratio of DM increased by 1.94, 2.52,1.57, and 4.87 times for obesity(25-29.9kg/m²), high obesity(≥30kg/m²), depression, and receipt of psychological counseling for depression, respectively. In Jeonbuk, the odds ratio of DM increased by 1.79, 2.84, and 3.59 times for obesity, high obesity, and unmet medical experience, respectively. On the other hand, depression-related variables were found to not influence DM Conclusion: We provided the rationale for conducting a health project that interventions for obesity and depression should be included in DM management programs differently in Ulsan and Jeonbuk regions
背景:糖尿病(DM)的发病率因地区而异。本研究旨在确定不同地区肥胖和抑郁对韩国成年人糖尿病影响的差异。研究方法研究对象是来自蔚山(DM发病率最低的地区)和全北(DM发病率最高的地区)的14343名成年人(≥30岁),数据来自2019年社区健康调查。我们采用了复杂的抽样设计分析,以反映分层、聚类和加权的情况。数据分析采用非加权频数、加权百分比、平均值、标准误差、Chi-Square 检验和多元逻辑回归分析(SPSS 25.0)。结果在蔚山的主要结果中,肥胖(25-29.9kg/m²)、高度肥胖(≥30kg/m²)、抑郁和接受抑郁心理咨询的 DM 的几率分别增加了 1.94 倍、2.52 倍、1.57 倍和 4.87 倍。在全北,肥胖、高度肥胖和未满足医疗经验的 DM 的几率比分别增加了 1.79 倍、2.84 倍和 3.59 倍。另一方面,抑郁相关变量并不影响 DM 结论:我们提供了在蔚山和全北地区开展健康项目的理由,即肥胖和抑郁的干预措施应被纳入不同的 DM 管理计划中。
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引用次数: 0
Application of Machine Learning Algorithms to Analyze the Clinical Characteristics of NIHL Caused by Impulse Noise and Steady Noise 应用机器学习算法分析脉冲噪声和稳定噪声导致的 NIHL 临床特征
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-13 DOI: 10.18502/ijph.v53i7.16048
Boya Fan, Gang Wang, Wei Wu
Background: Occupational hearing loss of workers exposed to impulse noise and workers exposed to steady noise for a long time may have different clinical characteristics. Methods: As of May 2019, all 92 servicemen working in a weapon experimental field exposed to impulse noise for over 1 year were collected as the impulse noise group. As of Dec 2019, all 78 servicemen working in an engine working experimental field exposed to steady noise for over 1 year were collected as the steady noise group. The propensity score matching (PSM) model was used to eliminate the imbalance of age and working time between the two groups of subjects. After propensity score matching, 51 subjects in each group were finally included in the study. The machine learning model is constructed according to pure tone auditory threshold, and the performance of the machine learning model is evaluated by accuracy, sensitivity, specificity, and AUC. Results: Subjects in the impulse noise group and the steady noise group had significant hearing loss at high frequencies. The hearing of the steady noise group was worse than that of the impulse noise group at speech frequency especially at the frequency of 1 kHz. Among machine learning models, XGBoost has the best prediction and classification performance. Conclusion: The pure tone auditory threshold of subjects in both groups decreased and at high frequency. The hearing of the steady noise group at 1 kHz was significantly worse than that of the impulse noise group. XGBoost is the best model to predict the classification of our two groups. Our research can guide the prevention of damage caused by different types of noises.
背景:暴露于脉冲噪声的工人和长期暴露于稳定噪声的工人的职业性听力损失可能具有不同的临床特征。研究方法截至2019年5月,收集在武器实验场工作1年以上暴露于脉冲噪声的所有92名军人作为脉冲噪声组。截至 2019 年 12 月,收集了在发动机工作实验场暴露于稳定噪声 1 年以上的所有 78 名军人,作为稳定噪声组。采用倾向得分匹配(PSM)模型消除两组受试者在年龄和工作时间上的不平衡。经过倾向得分匹配后,两组各 51 名受试者最终被纳入研究。根据纯音听觉阈值构建机器学习模型,并通过准确性、灵敏度、特异性和 AUC 评估机器学习模型的性能。研究结果脉冲噪声组和稳定噪声组的受试者在高频处听力明显下降。在语音频率,尤其是 1 kHz 频率时,稳定噪声组的听力比脉冲噪声组差。在机器学习模型中,XGBoost 的预测和分类性能最好。结论两组受试者的纯音听觉阈值均有所下降,且在高频率时有所下降。稳定噪声组在 1 kHz 频率下的听力明显差于脉冲噪声组。XGBoost 是预测两组分类的最佳模型。我们的研究可以为预防不同类型噪音造成的损害提供指导。
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引用次数: 0
Correlation Study of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) on Diabetic Patients with Hypertension 胰高血糖素样肽-1 受体激动剂(GLP-1RAs)对糖尿病高血压患者的相关性研究
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-13 DOI: 10.18502/ijph.v53i7.16050
Yeting Chang, Qin Yu
Background: We aimed to investigate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on blood pressure, blood glucose and blood lipid in diabetic patients with hypertension. Methods: A total of 300 diabetic patients and essential hypertension admitted to the Second Affiliated Hospital of Dalian Medical University, Dalian, China from January 2021 to December 2022 were selected. They were divided into an observation group and a control group using a random number table method. The control group was treated with conventional antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs. The observation group was supplemented with liraglutide based on the control group. Blood pressure, blood glucose and blood lipid of the two groups were compared at the initial stage of medication and after 4 weeks and half a year, and the influencing factors of patients with persistent hypertension were further analyzed through Logistic regression. Results: After 4 weeks and 6 months of medication, inter group comparisons showed that systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBG) and glycated hemoglobin (HbA1c), as well as total cholesterol (TC), triacylglycerol (TG), and plasma arteriosclerosis index (AIP) in the observation group were significantly lower than those in the control group (Ρ<0.05). Multivariate Logistic regression model analysis showed that age, smoking history, drinking history, taking conventional antihypertensive drugs, taking hypoglycemic drugs, taking lipid-lowering drugs, BMI, FBG, HbA1c and LDL-C were independent influencing factors for persistent hypertension (Ρ<0.05). Conclusion: GLP-1RAs could effectively improve the indexes including blood pressure, blood glucose and blood lipid in diabetic patients with hypertension.  
背景:我们旨在研究胰高血糖素样肽-1 受体激动剂(GLP-1RAs)对糖尿病高血压患者血压、血糖和血脂的影响。研究方法选取 2021 年 1 月至 2022 年 12 月大连医科大学附属第二医院收治的 300 例糖尿病合并原发性高血压患者。采用随机数字表法将其分为观察组和对照组。对照组采用常规降压药、降糖药和降脂药治疗。观察组在对照组的基础上补充利拉鲁肽。比较两组患者服药初期、4周后和半年后的血压、血糖和血脂,并通过Logistic回归进一步分析顽固性高血压患者的影响因素。结果用药 4 周和 6 个月后,组间比较显示,观察组收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、血浆动脉硬化指数(AIP)均明显低于对照组(Ρ<0.05)。多变量 Logistic 回归模型分析显示,年龄、吸烟史、饮酒史、服用常规降压药、服用降糖药、服用降脂药、BMI、FBG、HbA1c 和 LDL-C 是持续性高血压的独立影响因素(Ρ<0.05)。结论GLP-1RAs 能有效改善糖尿病高血压患者的血压、血糖和血脂等指标。
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引用次数: 0
The Performance of the Current Algorithm of HIV Diagnosis 当前艾滋病毒诊断算法的性能
IF 1.4 4区 医学 Q3 Medicine Pub Date : 2024-07-13 DOI: 10.18502/ijph.v53i7.16051
Abdurrahman Gulmez, Ozgur Appak, A. N. Zeka, Nuran Esen, A. Sayıner
Background: We aimed to evaluate the performance of the current algorithm the HIV diagnosis that has been performed for four years. Results of HIV Ag/Ab tests, anti-HIV 1/2 confirmatory tests, HIV-1 RNA tests and the time for official results to be approved were evaluated. Methods: The relationship of HIV Ag/Ab tests, anti-HIV 1/2 confirmation tests and HIV-1 RNA PCR tests, their result times and suitability to the algorithm were examined at Izmir Dokuz Eylül University between May 2017 and June 2021. Results: HIV Ag/Ab ELISA was reactive repetitively in 165/54628 (0.30%) serum samples. Anti-HIV 1/2 confir-mation test was reactive in 54.42% (80/147) of samples. The most common pattern (18.2%) in the con-firmation tests was the positivity of the antibodies against gp160 - gp41 envelope glycoproteins together. The mean reporting time of the confirmation test result was 3h 50 min after the ELISA test. The mean reporting time of the HIV-1 RNA PCR was 12.79 d (±10.22) after the ELISA test and 12.63 (± 10.12) day after the confirmation test. In ROC analysis, the estimated rate of the ELISA test for the confirmation test was highest when S/CO was >13.16 (sensitivity: 97.59 %, specificity: 97.59%). Conclusion: The confirmation test in the current algorithm enabled the rapid test results, early diagnosis of HIV and early antiretroviral therapy. To use the new algorithm effectively, decentralization of the validation tests would be appropriate.
背景:我们的目的是评估已实施四年的现行艾滋病诊断算法的性能。我们对 HIV Ag/Ab 检测结果、抗 HIV 1/2 确证检测结果、HIV-1 RNA 检测结果以及正式结果获得批准的时间进行了评估。方法在 2017 年 5 月至 2021 年 6 月期间,在伊兹密尔 Dokuz Eylül 大学对 HIV Ag/Ab 检测、抗 HIV 1/2 确认检测和 HIV-1 RNA PCR 检测的关系、结果时间和算法的适用性进行了研究。结果显示在 165/54628 份(0.30%)血清样本中,HIV Ag/Ab ELISA 呈重复反应。54.42% (80/147)的样本中,抗 HIV 1/2confir-mation检测呈反应性。确证试验中最常见的模式(18.2%)是 gp160 - gp41 包膜糖蛋白抗体同时阳性。确认检测结果的平均报告时间为 ELISA 检测后 3 小时 50 分钟。HIV-1 RNA PCR 的平均报告时间为 ELISA 检测后 12.79 天(±10.22)和确认检测后 12.63 天(±10.12)。在 ROC 分析中,当 S/CO >13.16 时,ELISA 检测用于确认检测的估计比率最高(灵敏度:97.59%,特异性:97.59%)。结论现行算法中的确证试验能够快速得出检测结果,及早诊断出艾滋病病毒,并及早进行抗逆转录病毒治疗。为有效使用新算法,应分散进行确认检验。
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Iranian Journal of Public Health
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