Richard was mainly known as a gifted scientist, a charismatic leader, and an original and creative President. And he was my good friend and a role model for over three decades. The term impossible was not part of his vocabulary. I′ve learned from him that there is no limit to imagination and creativity, no limit to the number of assignments one can fulfill, and no limit to the magnitude of a dream one can turn into reality. Richard was blessed with the unique talent to quickly decipher the essence of people‘s thoughts and discover the hidden parts of their personalities, which allowed him to focus on what he defined as the most valuable issues and productive discussions. My experience with him included the joy of scientific discovery, the silent mode of human communication, the power of commitment and dedication, and the wildest sense of humor. Now, nearly two years after his departure, I feel free and obliged to share unknown stories and anecdotes that illuminate various facets of his personality.
{"title":"Richard A. Lerner – Little Known Facets of an Outstanding Man","authors":"Ehud Keinan","doi":"10.1002/ijch.202300140","DOIUrl":"https://doi.org/10.1002/ijch.202300140","url":null,"abstract":"<p>Richard was mainly known as a gifted scientist, a charismatic leader, and an original and creative President. And he was my good friend and a role model for over three decades. The term impossible was not part of his vocabulary. I′ve learned from him that there is no limit to imagination and creativity, no limit to the number of assignments one can fulfill, and no limit to the magnitude of a dream one can turn into reality. Richard was blessed with the unique talent to quickly decipher the essence of people‘s thoughts and discover the hidden parts of their personalities, which allowed him to focus on what he defined as the most valuable issues and productive discussions. My experience with him included the joy of scientific discovery, the silent mode of human communication, the power of commitment and dedication, and the wildest sense of humor. Now, nearly two years after his departure, I feel free and obliged to share unknown stories and anecdotes that illuminate various facets of his personality.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract RE‐Au‐Si (RE=Ho, Tb) systems are 1/1 Tsai‐type quasicrystalline approximants with a cluster center decoration that can vary from a disordered tetrahedron to a rare‐earth atom. The local atomic structure of three different samples was observed by scanning transmission electron microscopy and interpreted in the light of high‐angle annular dark field simulated scanning transmission electron microscopy images. It is found that the combination of these two methods allows to identify differences in the chemical decoration of the cluster centers through quantitative analysis of line profiles.
RE - Au - Si (RE=Ho, Tb)体系是具有团簇中心修饰的1/1 Tsai型准晶近似体，可以是无序四面体，也可以是稀土原子。用扫描透射电子显微镜观察了三种不同样品的局部原子结构，并用高角度环形暗场模拟扫描透射电子显微镜图像对其进行了解释。研究发现，这两种方法的结合可以通过对线形的定量分析来识别簇中心化学装饰的差异。
{"title":"STEM Structural Investigation of RE‐Au‐Si 1/1 Approximants","authors":"Wilfried Bajoun Mbajoun, Vinko Sršan, Yu‐Chin. Huang, Girma Hailu Gebresenbut, Cesar Pay Gómez, Sylvie Migot‐Choux, Jaafar Ghanbaja, Sašo Šturm, Vincent Fournée, Julian Ledieu","doi":"10.1002/ijch.202300117","DOIUrl":"https://doi.org/10.1002/ijch.202300117","url":null,"abstract":"Abstract RE‐Au‐Si (RE=Ho, Tb) systems are 1/1 Tsai‐type quasicrystalline approximants with a cluster center decoration that can vary from a disordered tetrahedron to a rare‐earth atom. The local atomic structure of three different samples was observed by scanning transmission electron microscopy and interpreted in the light of high‐angle annular dark field simulated scanning transmission electron microscopy images. It is found that the combination of these two methods allows to identify differences in the chemical decoration of the cluster centers through quantitative analysis of line profiles.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134901655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atreyee Halder, Kingshuk Mahanty, Debabrata Maiti, Dr. Suman De Sarkar
In recent decades, electro-organic synthesis is indubitably emerging as a cornerstone of modern organic chemistry. Electrochemical organic transformations especially reduction reactions have made massive advancements in the last few years because of their sustainable and environ-friendly nature. Electro-reductive protocols can be used as a promising substitute for conventional reductants by expelling the requirement of the stoichiometric amount of metal reductants. The major challenges for these electro-reductive reactions are primarily the use of a sacrificial electrode and divided cells. These limitations can be resolved through smart reaction planning by employing cheap sacrificial reagents or paired electrolysis without compromising the sustainable viewpoint. Considering the rapid enhancement in this field, imparting an intangible understanding of this evolving area is essential and substantial. In this review, we portrayed the electrochemical reductive transformations of C−C and C−O bonds after 2015 along with detailed mechanistic insights.
{"title":"Recent Advances in Electrochemical Reductive Transformation of C−C and C−O Multiple Bonds","authors":"Atreyee Halder, Kingshuk Mahanty, Debabrata Maiti, Dr. Suman De Sarkar","doi":"10.1002/ijch.202300102","DOIUrl":"10.1002/ijch.202300102","url":null,"abstract":"<p>In recent decades, electro-organic synthesis is indubitably emerging as a cornerstone of modern organic chemistry. Electrochemical organic transformations especially reduction reactions have made massive advancements in the last few years because of their sustainable and environ-friendly nature. Electro-reductive protocols can be used as a promising substitute for conventional reductants by expelling the requirement of the stoichiometric amount of metal reductants. The major challenges for these electro-reductive reactions are primarily the use of a sacrificial electrode and divided cells. These limitations can be resolved through smart reaction planning by employing cheap sacrificial reagents or paired electrolysis without compromising the sustainable viewpoint. Considering the rapid enhancement in this field, imparting an intangible understanding of this evolving area is essential and substantial. In this review, we portrayed the electrochemical reductive transformations of C−C and C−O bonds after 2015 along with detailed mechanistic insights.</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica D. Rosarda, Caroline R. Stanton, Emily B. Chen, Michael J. Bollong, R. Luke Wiseman
Abstract The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro‐inflammatory cytokines such as IL‐1β. Hyperactivation of NLRP3 inflammasome signaling is implicated in the onset and pathogenesis of numerous diseases, motivating the discovery of new strategies to suppress NLRP3 inflammasome activity. We sought to define the potential for the proteostasis regulator AA147 to inhibit the assembly and activation of the NLRP3 inflammasome. AA147 is a pro‐drug that is metabolically converted to a reactive metabolite at the endoplasmic reticulum (ER) membrane to covalently modify ER‐localized proteins such as protein disulfide isomerases (PDIs). We show that AA147 inhibits NLRP3 inflammasome activity in monocytes and monocyte‐derived macrophages through a mechanism involving impaired assembly of the active inflammasome complex. This inhibition is mediated through AA147‐dependent covalent modification of PDIA1. Genetic depletion or treatment with other highly selective PDIA1 inhibitors similarly blocks NLRP3 inflammasome assembly and activation. Our results identify PDIA1 as a potential therapeutic target to mitigate NLRP3 inflammasome‐mediated pro‐inflammatory signaling implicated in etiologically diverse diseases.
{"title":"Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation","authors":"Jessica D. Rosarda, Caroline R. Stanton, Emily B. Chen, Michael J. Bollong, R. Luke Wiseman","doi":"10.1002/ijch.202300125","DOIUrl":"https://doi.org/10.1002/ijch.202300125","url":null,"abstract":"Abstract The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro‐inflammatory cytokines such as IL‐1β. Hyperactivation of NLRP3 inflammasome signaling is implicated in the onset and pathogenesis of numerous diseases, motivating the discovery of new strategies to suppress NLRP3 inflammasome activity. We sought to define the potential for the proteostasis regulator AA147 to inhibit the assembly and activation of the NLRP3 inflammasome. AA147 is a pro‐drug that is metabolically converted to a reactive metabolite at the endoplasmic reticulum (ER) membrane to covalently modify ER‐localized proteins such as protein disulfide isomerases (PDIs). We show that AA147 inhibits NLRP3 inflammasome activity in monocytes and monocyte‐derived macrophages through a mechanism involving impaired assembly of the active inflammasome complex. This inhibition is mediated through AA147‐dependent covalent modification of PDIA1. Genetic depletion or treatment with other highly selective PDIA1 inhibitors similarly blocks NLRP3 inflammasome assembly and activation. Our results identify PDIA1 as a potential therapeutic target to mitigate NLRP3 inflammasome‐mediated pro‐inflammatory signaling implicated in etiologically diverse diseases.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract The proteasome is comprised of multiple subunits that catalyze the degradation of proteins to maintain cellular homeostasis. The proteasome targets protein substrates by two different pathways. The ubiquitin‐dependent pathway requires proteins to be labeled with a ubiquitin tag to signal for degradation by the 26S isoform of the proteasome. Protein degradation through this pathway declines during age progression. The ubiquitin‐independent pathway utilizes the 20S proteasome isoform. It can degrade misfolded and intrinsically disordered proteins to decrease cellular stress. Age‐related protein accumulation and aggregation can occur due to the decreased activity and expression of the proteasome. Protein accumulation causes increased cellular stress which can contribute to disease progression. Increasing proteasome activity could serve as a solution to eliminating and preventing protein accumulation. Studies have shown the value of the proteasome as a therapeutic entity to mitigate cellular stress. This perspective explores the link between proteasome activity and cellular stress caused by age‐related misfolded protein accumulation.
{"title":"The Role of the Proteasome in Limiting Cellular Stress Associated with Protein Accumulation","authors":"Kate A. Kragness, Darci J. Trader","doi":"10.1002/ijch.202300120","DOIUrl":"https://doi.org/10.1002/ijch.202300120","url":null,"abstract":"Abstract The proteasome is comprised of multiple subunits that catalyze the degradation of proteins to maintain cellular homeostasis. The proteasome targets protein substrates by two different pathways. The ubiquitin‐dependent pathway requires proteins to be labeled with a ubiquitin tag to signal for degradation by the 26S isoform of the proteasome. Protein degradation through this pathway declines during age progression. The ubiquitin‐independent pathway utilizes the 20S proteasome isoform. It can degrade misfolded and intrinsically disordered proteins to decrease cellular stress. Age‐related protein accumulation and aggregation can occur due to the decreased activity and expression of the proteasome. Protein accumulation causes increased cellular stress which can contribute to disease progression. Increasing proteasome activity could serve as a solution to eliminating and preventing protein accumulation. Studies have shown the value of the proteasome as a therapeutic entity to mitigate cellular stress. This perspective explores the link between proteasome activity and cellular stress caused by age‐related misfolded protein accumulation.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135480424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Amyloid fibril deposition causes progressive tissue damage and organ failure in the systemic amyloid diseases, and therapies that suppress aggregation lead to clinical benefit. Small molecules that prevent aggregation by binding to precursor proteins are effective for amyloid transthyretin (ATTR) amyloidosis. However, in amyloid light chain (AL) amyloidosis, fibrils are formed by antibody light chains and every patient has a unique protein sequence that aggregates. The highly diverse sequences of these light chains appear to determine whether an individual is at risk of amyloidosis, the distribution of amyloid deposits and the progression of disease. Light chains are therefore challenging drug targets. This review explores the parallels between AL amyloidosis and ATTR amyloidosis to describe the discovery of small molecules that can stabilize light chains. These molecules have potential as therapies for AL amyloidosis, highlighting potential opportunities for drug discovery in other diseases of protein misfolding.
{"title":"Understanding and Overcoming Biochemical Diversity in AL Amyloidosis","authors":"Gareth J. Morgan","doi":"10.1002/ijch.202300128","DOIUrl":"https://doi.org/10.1002/ijch.202300128","url":null,"abstract":"Abstract Amyloid fibril deposition causes progressive tissue damage and organ failure in the systemic amyloid diseases, and therapies that suppress aggregation lead to clinical benefit. Small molecules that prevent aggregation by binding to precursor proteins are effective for amyloid transthyretin (ATTR) amyloidosis. However, in amyloid light chain (AL) amyloidosis, fibrils are formed by antibody light chains and every patient has a unique protein sequence that aggregates. The highly diverse sequences of these light chains appear to determine whether an individual is at risk of amyloidosis, the distribution of amyloid deposits and the progression of disease. Light chains are therefore challenging drug targets. This review explores the parallels between AL amyloidosis and ATTR amyloidosis to describe the discovery of small molecules that can stabilize light chains. These molecules have potential as therapies for AL amyloidosis, highlighting potential opportunities for drug discovery in other diseases of protein misfolding.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135679326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sam Coates, Dominic Burnie, Hem Raj Sharma, Ronan McGrath
Abstract We review scanning tunnelling microscopy (STM) studies of the surfaces of periodic Tsai‐type approximants. Although they are useful analogues to the Tsai‐type quasicrystals, the surfaces of these periodic approximants behave in subtly different and often more complex ways when compared to their quasiperiodic cousins. We present a summary of STM studies conducted upon Tsai‐type approximants; we discuss the various differences and similarities between phases and surface directions, and compare these to the surfaces of the related quasicrystalline phases. We also present open questions which have been raised by these studies, and offer potential routes to answer them.
{"title":"Scanning Tunnelling Microscopy Studies of Tsai‐Type Quasicrystal Approximants","authors":"Sam Coates, Dominic Burnie, Hem Raj Sharma, Ronan McGrath","doi":"10.1002/ijch.202300116","DOIUrl":"https://doi.org/10.1002/ijch.202300116","url":null,"abstract":"Abstract We review scanning tunnelling microscopy (STM) studies of the surfaces of periodic Tsai‐type approximants. Although they are useful analogues to the Tsai‐type quasicrystals, the surfaces of these periodic approximants behave in subtly different and often more complex ways when compared to their quasiperiodic cousins. We present a summary of STM studies conducted upon Tsai‐type approximants; we discuss the various differences and similarities between phases and surface directions, and compare these to the surfaces of the related quasicrystalline phases. We also present open questions which have been raised by these studies, and offer potential routes to answer them.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135973475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Predicting quasicrystal structures is a multifaceted problem that can involve predicting a previously unknown phase, predicting the structure of an experimentally observed phase, or predicting the thermodynamic stability of a given structure. We survey the history and current state of these prediction efforts with a focus on methods that have improved our understanding of the structure and stability of known metallic quasicrystal phases. Advances in the structural modeling of quasicrystals, along with first principles total energy calculation and statistical mechanical methods that enable the calculation of quasicrystal thermodynamic stability, are illustrated by means of cited examples of recent work.
{"title":"Quasicrystal Structure Prediction: A Review","authors":"Michael Widom, Marek Mihalkovič","doi":"10.1002/ijch.202300122","DOIUrl":"https://doi.org/10.1002/ijch.202300122","url":null,"abstract":"Abstract Predicting quasicrystal structures is a multifaceted problem that can involve predicting a previously unknown phase, predicting the structure of an experimentally observed phase, or predicting the thermodynamic stability of a given structure. We survey the history and current state of these prediction efforts with a focus on methods that have improved our understanding of the structure and stability of known metallic quasicrystal phases. Advances in the structural modeling of quasicrystals, along with first principles total energy calculation and statistical mechanical methods that enable the calculation of quasicrystal thermodynamic stability, are illustrated by means of cited examples of recent work.","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136079036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruitu Lyu, Kinga Pajdzik, Hui-Lung Sun, Linda Zhang, Li-Sheng Zhang, Tong Wu, Lei Yang, Tao Pan, Chuan He, Qing Dai
5-Formylcytosine (f5C) modification is present in human mitochondrial methionine tRNA (mt-tRNAMet) and cytosolic leucine tRNA (ct-tRNALeu), with their formation mediated by NSUN3 and ALKBH1. f5C has also been detected in yeast mRNA and human tRNA, but its transcriptome-wide distribution in mammals has not been studied. Here we report f5C-seq, a quantitative sequencing method to map f5C transcriptome-wide in HeLa and mouse embryonic stem cells (mESCs). We show that f5C in RNA can be reduced to dihydrouracil (DHU) by pic-borane, and DHU can be exclusively read as T during reverse transcription (RT) reaction, allowing the detection and quantification of f5C sites by a unique C-to-T mutation signature. We validated f5C-seq by identifying and quantifying the two known f5C sites in tRNA, in which the f5C modification fractions dropped significantly in ALKBH1-depleted cells. By applying f5C-seq to chromatin-associated RNA (caRNA), we identified several highly modified f5C sites in HeLa and mouse embryonic stem cells (mESC).
5-甲酰基胞嘧啶（f5C）修饰存在于人类线粒体蛋氨酸 tRNA（mt-tRNAMet）和细胞质亮氨酸 tRNA（ct-tRNALeu）中，其形成由 NSUN3 和 ALKBH1 介导。在此，我们报告了一种定量测序方法 f5C-seq 在 HeLa 和小鼠胚胎干细胞（mESCs）中的全转录组分布图。我们的研究表明，RNA 中的 f5C 可被皮硼烷还原成二氢尿嘧啶（DHU），而 DHU 在反转录（RT）反应中可被完全读作 T，从而可通过独特的 C 到 T 突变特征来检测和量化 f5C 位点。我们通过识别和量化 tRNA 中的两个已知 f5C 位点验证了 f5C-seq。通过将 f5C-seq 应用于染色质相关 RNA（caRNA），我们在 HeLa 和小鼠胚胎干细胞（mESC）中发现了几个高度修饰的 f5C 位点。
{"title":"A Quantitative Sequencing Method for 5-Formylcytosine in RNA","authors":"Ruitu Lyu, Kinga Pajdzik, Hui-Lung Sun, Linda Zhang, Li-Sheng Zhang, Tong Wu, Lei Yang, Tao Pan, Chuan He, Qing Dai","doi":"10.1002/ijch.202300111","DOIUrl":"10.1002/ijch.202300111","url":null,"abstract":"<p>5-Formylcytosine (f<sup>5</sup>C) modification is present in human mitochondrial methionine tRNA (mt-tRNA<sup>Met</sup>) and cytosolic leucine tRNA (ct-tRNA<sup>Leu</sup>), with their formation mediated by NSUN3 and ALKBH1. f<sup>5</sup>C has also been detected in yeast mRNA and human tRNA, but its transcriptome-wide distribution in mammals has not been studied. Here we report f<sup>5</sup>C-seq, a quantitative sequencing method to map f<sup>5</sup>C transcriptome-wide in HeLa and mouse embryonic stem cells (mESCs). We show that f<sup>5</sup>C in RNA can be reduced to dihydrouracil (DHU) by pic-borane, and DHU can be exclusively read as T during reverse transcription (RT) reaction, allowing the detection and quantification of f<sup>5</sup>C sites by a unique C-to-T mutation signature. We validated f<sup>5</sup>C-seq by identifying and quantifying the two known f<sup>5</sup>C sites in tRNA, in which the f<sup>5</sup>C modification fractions dropped significantly in ALKBH1-depleted cells. By applying f<sup>5</sup>C-seq to chromatin-associated RNA (caRNA), we identified several highly modified f<sup>5</sup>C sites in HeLa and mouse embryonic stem cells (mESC).</p>","PeriodicalId":14686,"journal":{"name":"Israel Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ijch.202300111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136079035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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