Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.55780
Scott G Weiner, Kathryn F Hawk
{"title":"The Role of Peer Navigators After Nonfatal Opioid Overdose-Context, Evidence, and Future Directions.","authors":"Scott G Weiner, Kathryn F Hawk","doi":"10.1001/jamanetworkopen.2025.55780","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.55780","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2555780"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.57170
Vivien Foong Yee Tang, Da Jiang, Jojo Yan Yan Kwok, Dannii Yuen-Lan Yeung, Namkee G Choi, Lisa M Warner, Rainbow Tin Hung Ho, Kee-Lee Chou
<p><strong>Importance: </strong>Late-life loneliness is a serious public health concern, yet the long-term efficacy and mechanisms of interventions to alleviate it remain underexplored.</p><p><strong>Objective: </strong>To evaluate the 12-month effectiveness of lay counselor-delivered, telephone-based behavioral activation and mindfulness interventions in reducing loneliness and enhancing well-being among at-risk older adults and to examine whether social isolation mediates these effects.</p><p><strong>Design, setting, and participants: </strong>The Helping Alleviate Loneliness in Hong Kong Older Adults (HEAL-HOA) was a 3-arm, assessor-blinded randomized clinical trial conducted from April 1, 2021, to April 28, 2024. Eligible participants 65 years or older who were living alone, digitally excluded, lonely, and experiencing financial hardship were recruited from public housing estates, community centers, academies for older adults, and word of mouth. Participants were randomized 1:1:1 to receive telephone-delivered behavioral activation (Tele-BA), telephone-delivered mindfulness (Tele-MF), or telephone-delivered befriending (Tele-BF [attention control]).</p><p><strong>Interventions: </strong>Participants received eight 30-minute sessions delivered by trained lay counselors via telephone for 4 weeks.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was loneliness, measured using the UCLA Loneliness Scale (UCLA-LS) and the De Jong Gierveld Loneliness Scale (DJGL). Secondary outcomes included perceived stress, social support, sleep quality, life satisfaction, anxiety, depressive symptoms, and psychological well-being. Social isolation was examined as a mediator. Outcomes were assessed at baseline and at 1, 3, 6, and 12 months of follow-up.</p><p><strong>Results: </strong>Of 4152 individuals screened, 1151 participants (mean [SD] age, 76.6 [7.8] years; 843 [73.2%] female; 965 [83.8%] with ≥1 chronic illness) were randomized (Tele-BA, 335 [29.1%]; Tele-MF, 460 [40.0%]; Tele-BF, 356 [30.9%]). Intention-to-treat analyses using linear mixed-effects models showed significant between-group changes in loneliness at 12 months for Tele-BA (UCLA-LS: mean difference [MD], -0.73; 95% CI, -1.29 to -0.16; P = .01; DJGL: MD, -0.13; 95% CI, -0.23 to -0.03; P = .01) and Tele-MF (UCLA-LS: MD, -0.72; 95% CI, -1.24 to -0.20; P = .003) compared with Tele-BF. Secondary outcomes, including sleep quality, psychological well-being, and life satisfaction, also improved significantly. Social isolation at 6 months partially mediated the effect on loneliness (UCLA-LS) for both interventions at 12 months (accounting for 0.13 [13.5%] and 0.18 [18.0%] of the total effects for Tele-BA and Tele-MF, respectively).</p><p><strong>Conclusions and relevance: </strong>In this randomized clinical trial, brief telephone-delivered behavioral activation and mindfulness interventions by lay counselors sustainably reduced loneliness and enhanced well-being during 12 months i
{"title":"Behavioral Activation and Mindfulness Interventions in Reducing Loneliness and Improving Well-Being in Older Adults: The HEAL-HOA Randomized Clinical Trial.","authors":"Vivien Foong Yee Tang, Da Jiang, Jojo Yan Yan Kwok, Dannii Yuen-Lan Yeung, Namkee G Choi, Lisa M Warner, Rainbow Tin Hung Ho, Kee-Lee Chou","doi":"10.1001/jamanetworkopen.2025.57170","DOIUrl":"10.1001/jamanetworkopen.2025.57170","url":null,"abstract":"<p><strong>Importance: </strong>Late-life loneliness is a serious public health concern, yet the long-term efficacy and mechanisms of interventions to alleviate it remain underexplored.</p><p><strong>Objective: </strong>To evaluate the 12-month effectiveness of lay counselor-delivered, telephone-based behavioral activation and mindfulness interventions in reducing loneliness and enhancing well-being among at-risk older adults and to examine whether social isolation mediates these effects.</p><p><strong>Design, setting, and participants: </strong>The Helping Alleviate Loneliness in Hong Kong Older Adults (HEAL-HOA) was a 3-arm, assessor-blinded randomized clinical trial conducted from April 1, 2021, to April 28, 2024. Eligible participants 65 years or older who were living alone, digitally excluded, lonely, and experiencing financial hardship were recruited from public housing estates, community centers, academies for older adults, and word of mouth. Participants were randomized 1:1:1 to receive telephone-delivered behavioral activation (Tele-BA), telephone-delivered mindfulness (Tele-MF), or telephone-delivered befriending (Tele-BF [attention control]).</p><p><strong>Interventions: </strong>Participants received eight 30-minute sessions delivered by trained lay counselors via telephone for 4 weeks.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was loneliness, measured using the UCLA Loneliness Scale (UCLA-LS) and the De Jong Gierveld Loneliness Scale (DJGL). Secondary outcomes included perceived stress, social support, sleep quality, life satisfaction, anxiety, depressive symptoms, and psychological well-being. Social isolation was examined as a mediator. Outcomes were assessed at baseline and at 1, 3, 6, and 12 months of follow-up.</p><p><strong>Results: </strong>Of 4152 individuals screened, 1151 participants (mean [SD] age, 76.6 [7.8] years; 843 [73.2%] female; 965 [83.8%] with ≥1 chronic illness) were randomized (Tele-BA, 335 [29.1%]; Tele-MF, 460 [40.0%]; Tele-BF, 356 [30.9%]). Intention-to-treat analyses using linear mixed-effects models showed significant between-group changes in loneliness at 12 months for Tele-BA (UCLA-LS: mean difference [MD], -0.73; 95% CI, -1.29 to -0.16; P = .01; DJGL: MD, -0.13; 95% CI, -0.23 to -0.03; P = .01) and Tele-MF (UCLA-LS: MD, -0.72; 95% CI, -1.24 to -0.20; P = .003) compared with Tele-BF. Secondary outcomes, including sleep quality, psychological well-being, and life satisfaction, also improved significantly. Social isolation at 6 months partially mediated the effect on loneliness (UCLA-LS) for both interventions at 12 months (accounting for 0.13 [13.5%] and 0.18 [18.0%] of the total effects for Tele-BA and Tele-MF, respectively).</p><p><strong>Conclusions and relevance: </strong>In this randomized clinical trial, brief telephone-delivered behavioral activation and mindfulness interventions by lay counselors sustainably reduced loneliness and enhanced well-being during 12 months i","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2557170"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.55896
Deena Fremont, Amos Buh, Claire Hoar-Stephens, Nandini Biyani, Shaafi Mahbub, Ria Singla, Muhammad Zameer, Phalone Mei Nsen, Rachel Kang, Rohan Kiska, Stephen G Fung, Marco Solmi, Maya Gibb, Mekaylah Scott, Maria Salman, Kathryn Lee, Benjamin Milone, Gamal Wafy, Sarah Syed, Shan Dhaliwal, Ayub Akbari, Pierre A Brown, Gregory L Hundemer, Manish M Sood
Importance: Equity, diversity, and inclusion (EDI) initiatives are politically polarizing and increasingly adopted in the health care setting. Their broader impact across different health care career types, career stages, and various levels of education remains largely unknown.
Objective: To assess EDI programs and their associated outcomes within health care institutions.
Data sources: A Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020-compliant systematic review searching PubMed, Scopus, Web of Science, CINAHL, and PsychINFO databases from January 2010 to December 2023.
Study selection: Two independent reviewers screened studies that assessed EDI programs or policies in health care institutions.
Data extraction and synthesis: Programs were categorized based on reported outcomes, including participant satisfaction, increased awareness of EDI-related topics, increases in the proportion of underrepresented minority individuals within medical education or the health care workforce, and overall program impact. Odds ratios (ORs) were pooled using a random-effects model. Analyses followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. Analysis was conducted June 2025.
Main outcomes and measures: Outcome measures included the proportion of diversity among the workforce, employee and patient satisfaction, and the proportion of employees recruited and retained after program implementation.
Results: In total, 43 studies incorporating more than 15 000 individuals involved in EDI programs were included. Interventions were multifaceted, including 14 career advancement and training programs, 16 diversity representation programs, 11 academia and research support initiatives, and the growth of 2 pipeline programs. Furthermore, interventions demonstrated consistent improvement in EDI initiatives, with perceived benefit in promoting underrepresented minority populations. Findings from the meta-analysis of 2 studies showed that minority representation in competitive medical residencies increased after implementation of 2 EDI interventions (OR, 1.73; 95% CI, 1.21-2.47). Among the 43 studies included in the Joanna Briggs Institute assessment of methodological quality, 7 (16.3%) were rated as high quality, 20 (46.5%) as moderate quality, and 16 (37.2%) as low quality.
Conclusions and relevance: In this systematic review and meta-analysis of EDI initiatives in health care institutions, programs were associated with an increased workforce diversity. These findings support the continued use of EDI initiatives to promote a more inclusive and equitable health care culture.
重要性:公平、多样性和包容(EDI)倡议在政治上两极分化,越来越多地在卫生保健环境中被采用。它们对不同医疗保健职业类型、职业阶段和不同教育水平的更广泛影响在很大程度上仍然未知。目的:评估卫生保健机构的电子数据交换项目及其相关结果。数据来源:2010年1月至2023年12月,检索PubMed, Scopus, Web of Science, CINAHL和PsychINFO数据库,符合系统评价和荟萃分析(PRISMA) 2020标准的首选报告项目。研究选择:两名独立审稿人筛选了评估医疗机构EDI项目或政策的研究。数据提取和综合:根据报告的结果对项目进行分类,包括参与者满意度、对电子数据管理相关主题的认识提高、医学教育或卫生保健工作人员中未被充分代表的少数群体比例的增加以及总体项目影响。使用随机效应模型汇总优势比(ORs)。分析遵循系统评价和元分析报告指南的首选报告项目。分析于2025年6月进行。主要结果和测量方法:结果测量方法包括劳动力多样性比例、员工和患者满意度、项目实施后招聘和保留员工的比例。结果:共纳入43项研究,涉及超过15,000 000人参与EDI计划。干预措施是多方面的,包括14个职业发展和培训项目,16个多元化代表项目,11个学术和研究支持项目,以及2个管道项目的增长。此外,干预措施显示了EDI倡议的持续改善,在促进未被充分代表的少数民族人口方面有明显的好处。2项研究的荟萃分析结果显示,实施2项EDI干预后,少数族裔在竞争性住院医师中的代表性增加(OR, 1.73; 95% CI, 1.21-2.47)。在乔安娜布里格斯研究所方法学质量评估纳入的43项研究中,7项(16.3%)为高质量,20项(46.5%)为中等质量,16项(37.2%)为低质量。结论和相关性:在对医疗机构EDI计划的系统回顾和荟萃分析中,计划与增加的劳动力多样性有关。这些发现支持继续使用电子数据交换倡议,以促进更加包容和公平的卫生保健文化。
{"title":"Equity, Diversity, and Inclusion Programs in Health Care Institutions: A Systematic Review and Meta-Analysis.","authors":"Deena Fremont, Amos Buh, Claire Hoar-Stephens, Nandini Biyani, Shaafi Mahbub, Ria Singla, Muhammad Zameer, Phalone Mei Nsen, Rachel Kang, Rohan Kiska, Stephen G Fung, Marco Solmi, Maya Gibb, Mekaylah Scott, Maria Salman, Kathryn Lee, Benjamin Milone, Gamal Wafy, Sarah Syed, Shan Dhaliwal, Ayub Akbari, Pierre A Brown, Gregory L Hundemer, Manish M Sood","doi":"10.1001/jamanetworkopen.2025.55896","DOIUrl":"10.1001/jamanetworkopen.2025.55896","url":null,"abstract":"<p><strong>Importance: </strong>Equity, diversity, and inclusion (EDI) initiatives are politically polarizing and increasingly adopted in the health care setting. Their broader impact across different health care career types, career stages, and various levels of education remains largely unknown.</p><p><strong>Objective: </strong>To assess EDI programs and their associated outcomes within health care institutions.</p><p><strong>Data sources: </strong>A Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) 2020-compliant systematic review searching PubMed, Scopus, Web of Science, CINAHL, and PsychINFO databases from January 2010 to December 2023.</p><p><strong>Study selection: </strong>Two independent reviewers screened studies that assessed EDI programs or policies in health care institutions.</p><p><strong>Data extraction and synthesis: </strong>Programs were categorized based on reported outcomes, including participant satisfaction, increased awareness of EDI-related topics, increases in the proportion of underrepresented minority individuals within medical education or the health care workforce, and overall program impact. Odds ratios (ORs) were pooled using a random-effects model. Analyses followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. Analysis was conducted June 2025.</p><p><strong>Main outcomes and measures: </strong>Outcome measures included the proportion of diversity among the workforce, employee and patient satisfaction, and the proportion of employees recruited and retained after program implementation.</p><p><strong>Results: </strong>In total, 43 studies incorporating more than 15 000 individuals involved in EDI programs were included. Interventions were multifaceted, including 14 career advancement and training programs, 16 diversity representation programs, 11 academia and research support initiatives, and the growth of 2 pipeline programs. Furthermore, interventions demonstrated consistent improvement in EDI initiatives, with perceived benefit in promoting underrepresented minority populations. Findings from the meta-analysis of 2 studies showed that minority representation in competitive medical residencies increased after implementation of 2 EDI interventions (OR, 1.73; 95% CI, 1.21-2.47). Among the 43 studies included in the Joanna Briggs Institute assessment of methodological quality, 7 (16.3%) were rated as high quality, 20 (46.5%) as moderate quality, and 16 (37.2%) as low quality.</p><p><strong>Conclusions and relevance: </strong>In this systematic review and meta-analysis of EDI initiatives in health care institutions, programs were associated with an increased workforce diversity. These findings support the continued use of EDI initiatives to promote a more inclusive and equitable health care culture.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2555896"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.57267
Ramlogan Sowamber, Alice J Mei, Paramdeep Kaur, Julianne McLeod, Emily McKay, Alex Lukey, Jamie Bakkum-Gamez, Natalia Buza, Paul A Cohen, Kyle Devins, Rhonda Farrell, Christine Garcia, Blake Gilks, Ellen Goode, Anjelica Hodgson, Brooke Howitt, Pei Hui, Jutta Huvila, Anthony Karnezis, Kianoosh Keyhanian, Mary Kinloch, Martin Köbel, Felix K F Kommoss, Lawrence Kushi, Janice S Kwon, Kara Long-Roche, Anais Malpica, Jessica N McAlpine, Dianne Miller, Esther Oliva, Andrea Palicelli, Aleksandra Paliga, Carlos Parra-Herran, Celeste Leigh Pearce, Sharnel Perera, Jurgen M Piek, Haiyan Qiu, Joseph Rabban, Robert Rome, Miranda Steenbeek, Rebecca Stone, Aline Talhouk, Kristin M Tischer, Britton Trabert, Penelope M Webb, John R Zalcberg, David G Huntsman, Gillian E Hanley
{"title":"Serous Ovarian Cancer Following Opportunistic Bilateral Salpingectomy.","authors":"Ramlogan Sowamber, Alice J Mei, Paramdeep Kaur, Julianne McLeod, Emily McKay, Alex Lukey, Jamie Bakkum-Gamez, Natalia Buza, Paul A Cohen, Kyle Devins, Rhonda Farrell, Christine Garcia, Blake Gilks, Ellen Goode, Anjelica Hodgson, Brooke Howitt, Pei Hui, Jutta Huvila, Anthony Karnezis, Kianoosh Keyhanian, Mary Kinloch, Martin Köbel, Felix K F Kommoss, Lawrence Kushi, Janice S Kwon, Kara Long-Roche, Anais Malpica, Jessica N McAlpine, Dianne Miller, Esther Oliva, Andrea Palicelli, Aleksandra Paliga, Carlos Parra-Herran, Celeste Leigh Pearce, Sharnel Perera, Jurgen M Piek, Haiyan Qiu, Joseph Rabban, Robert Rome, Miranda Steenbeek, Rebecca Stone, Aline Talhouk, Kristin M Tischer, Britton Trabert, Penelope M Webb, John R Zalcberg, David G Huntsman, Gillian E Hanley","doi":"10.1001/jamanetworkopen.2025.57267","DOIUrl":"10.1001/jamanetworkopen.2025.57267","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2557267"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.56024
Susan M Chang, Joanne A Smith, Amika S Wright, Julia Rowe-Porter, Kemisha Shaw-Kelly, Florencia Lopez-Boo, Susan P Walker
<p><strong>Importance: </strong>There is substantial evidence that programs that build parents' abilities to support early learning benefit children's development. Evidence is needed on how to integrate and scale these programs within government services.</p><p><strong>Objective: </strong>To determine whether a parenting program implemented by government primary health care services and combining in-person and remote delivery benefits children's development and parenting attitudes and behaviors.</p><p><strong>Design, setting, and participants: </strong>In this single-blind randomized clinical trial, enrollment began in July 2022 in primary health care centers in Jamaica. The intervention was phased in from September 2022 to August 2023 and lasted 8 months. Data collection ended in April 2024. Families with children aged 3 to 28 months from communities served by the centers were identified by health staff. Following eligibility checks and informed consent, families were randomly assigned to intervention or waiting list control.</p><p><strong>Intervention: </strong>The intervention aimed to strengthen parents' skills in helping their child learn through play and responsive interactions. Community health workers used a curriculum with age-appropriate play and language activities and made fortnightly contacts with families, alternating between home visits and telephone calls.</p><p><strong>Main outcomes and measures: </strong>Child development was measured with the Griffiths Mental Development Scales and parenting behaviors (involvement, responsivity, acceptance, and learning materials) with the Home Observation for Measurement of the Environment (HOME). Effect size (ES) was calculated by dividing the regression coefficient by the pooled-sample SD.</p><p><strong>Results: </strong>A total of 627 children were enrolled (311 intervention and 316 control; 322 [51.4%] male). At follow-up, 491 children (78.3%) were assessed, 237 (76.2%) of those in the intervention group and 254 (80.4%) in the control group. Children's mean (SD) age at follow-up was 27.0 (5.8) months in the control and 27.0 (6.1) months in the intervention group. A total of 393 mothers (62.7%) had completed secondary school. There were no significant differences in follow-up rate or characteristics between groups. Intention-to-treat multivariate regression analyses with inverse probability weights showed benefits for children's overall developmental quotient (ES, 0.17 SD; 95% CI, 0.01-0.33 SD), fine motor ability score (ES, 0.19 SD; 95% CI, 0.03-0.36 SD), and parent behaviors (HOME score ES, 0.25 SD; 95% CI, 0.08-0.41 SD).</p><p><strong>Conclusions and relevance: </strong>In this randomized clinical trial of a parenting program delivered through primary health care, the intervention benefited child development and parenting. Findings suggest combining in-person and remote methods may be a useful strategy for scaling.</p><p><strong>Trial registration: </strong>ISRCTN Registry Identifier: IS
{"title":"Blended Delivery of a Primary Care Parenting Program for Child Development: A Randomized Clinical Trial.","authors":"Susan M Chang, Joanne A Smith, Amika S Wright, Julia Rowe-Porter, Kemisha Shaw-Kelly, Florencia Lopez-Boo, Susan P Walker","doi":"10.1001/jamanetworkopen.2025.56024","DOIUrl":"10.1001/jamanetworkopen.2025.56024","url":null,"abstract":"<p><strong>Importance: </strong>There is substantial evidence that programs that build parents' abilities to support early learning benefit children's development. Evidence is needed on how to integrate and scale these programs within government services.</p><p><strong>Objective: </strong>To determine whether a parenting program implemented by government primary health care services and combining in-person and remote delivery benefits children's development and parenting attitudes and behaviors.</p><p><strong>Design, setting, and participants: </strong>In this single-blind randomized clinical trial, enrollment began in July 2022 in primary health care centers in Jamaica. The intervention was phased in from September 2022 to August 2023 and lasted 8 months. Data collection ended in April 2024. Families with children aged 3 to 28 months from communities served by the centers were identified by health staff. Following eligibility checks and informed consent, families were randomly assigned to intervention or waiting list control.</p><p><strong>Intervention: </strong>The intervention aimed to strengthen parents' skills in helping their child learn through play and responsive interactions. Community health workers used a curriculum with age-appropriate play and language activities and made fortnightly contacts with families, alternating between home visits and telephone calls.</p><p><strong>Main outcomes and measures: </strong>Child development was measured with the Griffiths Mental Development Scales and parenting behaviors (involvement, responsivity, acceptance, and learning materials) with the Home Observation for Measurement of the Environment (HOME). Effect size (ES) was calculated by dividing the regression coefficient by the pooled-sample SD.</p><p><strong>Results: </strong>A total of 627 children were enrolled (311 intervention and 316 control; 322 [51.4%] male). At follow-up, 491 children (78.3%) were assessed, 237 (76.2%) of those in the intervention group and 254 (80.4%) in the control group. Children's mean (SD) age at follow-up was 27.0 (5.8) months in the control and 27.0 (6.1) months in the intervention group. A total of 393 mothers (62.7%) had completed secondary school. There were no significant differences in follow-up rate or characteristics between groups. Intention-to-treat multivariate regression analyses with inverse probability weights showed benefits for children's overall developmental quotient (ES, 0.17 SD; 95% CI, 0.01-0.33 SD), fine motor ability score (ES, 0.19 SD; 95% CI, 0.03-0.36 SD), and parent behaviors (HOME score ES, 0.25 SD; 95% CI, 0.08-0.41 SD).</p><p><strong>Conclusions and relevance: </strong>In this randomized clinical trial of a parenting program delivered through primary health care, the intervention benefited child development and parenting. Findings suggest combining in-person and remote methods may be a useful strategy for scaling.</p><p><strong>Trial registration: </strong>ISRCTN Registry Identifier: IS","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2556024"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.57913
Harald Ehrhardt, Soodabeh Behboodi, Rolf F Maier, Adrien M Aubert, Ulrika Ådén, Birte Staude, Elizabeth S Draper, Anna Gudmundsdottir, Veronica Siljehav, Heili Varendi, Tom Weber, Michael Zemlin, Jennifer Zeitlin
<p><strong>Importance: </strong>The Apgar score, the first clinical assessment to direct measures to stabilize newborn infants, is also used for risk assessment. Its accuracy in estimating outcomes remains poor among very preterm (VPT) infants.</p><p><strong>Objective: </strong>To assess the utility of the combined 5-minute Apgar score and umbilical artery pH (UA-pH) for estimating risks of mortality and severe neonatal morbidity among VPT infants.</p><p><strong>Design, setting, and participants: </strong>This cohort study (Effective Perinatal Intensive Care in Europe [EPICE]) analyzed infants born at less than 32 weeks' gestation between April 2011 and September 2012 across 11 European countries. All liveborn VPT infants with Apgar scores and UA-pH data were included. Data were analyzed between February and December 2025.</p><p><strong>Exposures: </strong>Apgar score at 5 minutes and UA-pH. The Apgar score was classified as lower than 7 and 7 or higher, and the UA-pH values were categorized as low (<7.20) and normal (≥7.20). Four groups that combined these 2 measures were defined: Apgar score lower than 7 and low UA-pH; Apgar score lower than 7 and normal UA-pH; Apgar score 7 or higher and low UA-pH; and Apgar score 7 or higher and normal UA-pH.</p><p><strong>Main outcomes and measures: </strong>Combined outcome of mortality and/or any adverse morbidity (intraventricular hemorrhage [IVH] >grade 2, cystic periventricular leukomalacia, moderate or severe bronchopulmonary dysplasia [BPD], retinopathy of prematurity ≥stage 2, and necrotizing enterocolitis). Modified Poisson regression was used to estimate relative risks (RRs) between the exposure and the combined mortality and morbidity outcome and 3 individual components: mortality, IVH, and BPD. Models were adjusted for perinatal variables associated with Apgar score and UA-pH and adverse neonatal outcomes.</p><p><strong>Results: </strong>Of 7900 liveborn infants in the EPICE cohort, 4174 (52.8%) had information on Apgar score and UA-pH. These infants included 2249 males (53.9%) and had a median [IQR] gestational age of 29.9 [27.9-31.0] weeks and median [IQR] birth weight of 1240 [960-1520] g. A total of 367 infants (8.8%) had an Apgar score 7 or higher but a low UA-pH, 558 (13.4%) had an Apgar score lower than 7 but a normal UA-pH, and 196 (4.7%) had an Apgar score lower than 7 and a low UA-pH. Infants with an Apgar score lower than 7 had a higher frequency of the combined outcome among those with a normal UA-pH (270 [48.4%] vs 596 [19.5%]) and a low UA-pH (108 [55.1%] vs 596 [19.5%]), with similar adjusted RRs (ARRs; low: 1.4 [95% CI, 1.2-1.7]; normal: 1.4 [95% CI, 1.3-1.6]). For mortality risk, associations were robust for an Apgar score lower than 7 and a low UA-pH (ARR, 2.4; 95% CI, 1.7-3.3) and absent with an Apgar score of 7 or higher and a low UA-pH (ARR, 1.2; 95% CI, 0.8-1.8). IVH risk was increased in all 3 subcategories, including an Apgar score of 7 or higher with a low UA-pH (ARR, 2.0
{"title":"Apgar Score Plus Umbilical Artery pH and Adverse Neonatal Outcomes in Very Preterm Infants.","authors":"Harald Ehrhardt, Soodabeh Behboodi, Rolf F Maier, Adrien M Aubert, Ulrika Ådén, Birte Staude, Elizabeth S Draper, Anna Gudmundsdottir, Veronica Siljehav, Heili Varendi, Tom Weber, Michael Zemlin, Jennifer Zeitlin","doi":"10.1001/jamanetworkopen.2025.57913","DOIUrl":"10.1001/jamanetworkopen.2025.57913","url":null,"abstract":"<p><strong>Importance: </strong>The Apgar score, the first clinical assessment to direct measures to stabilize newborn infants, is also used for risk assessment. Its accuracy in estimating outcomes remains poor among very preterm (VPT) infants.</p><p><strong>Objective: </strong>To assess the utility of the combined 5-minute Apgar score and umbilical artery pH (UA-pH) for estimating risks of mortality and severe neonatal morbidity among VPT infants.</p><p><strong>Design, setting, and participants: </strong>This cohort study (Effective Perinatal Intensive Care in Europe [EPICE]) analyzed infants born at less than 32 weeks' gestation between April 2011 and September 2012 across 11 European countries. All liveborn VPT infants with Apgar scores and UA-pH data were included. Data were analyzed between February and December 2025.</p><p><strong>Exposures: </strong>Apgar score at 5 minutes and UA-pH. The Apgar score was classified as lower than 7 and 7 or higher, and the UA-pH values were categorized as low (<7.20) and normal (≥7.20). Four groups that combined these 2 measures were defined: Apgar score lower than 7 and low UA-pH; Apgar score lower than 7 and normal UA-pH; Apgar score 7 or higher and low UA-pH; and Apgar score 7 or higher and normal UA-pH.</p><p><strong>Main outcomes and measures: </strong>Combined outcome of mortality and/or any adverse morbidity (intraventricular hemorrhage [IVH] >grade 2, cystic periventricular leukomalacia, moderate or severe bronchopulmonary dysplasia [BPD], retinopathy of prematurity ≥stage 2, and necrotizing enterocolitis). Modified Poisson regression was used to estimate relative risks (RRs) between the exposure and the combined mortality and morbidity outcome and 3 individual components: mortality, IVH, and BPD. Models were adjusted for perinatal variables associated with Apgar score and UA-pH and adverse neonatal outcomes.</p><p><strong>Results: </strong>Of 7900 liveborn infants in the EPICE cohort, 4174 (52.8%) had information on Apgar score and UA-pH. These infants included 2249 males (53.9%) and had a median [IQR] gestational age of 29.9 [27.9-31.0] weeks and median [IQR] birth weight of 1240 [960-1520] g. A total of 367 infants (8.8%) had an Apgar score 7 or higher but a low UA-pH, 558 (13.4%) had an Apgar score lower than 7 but a normal UA-pH, and 196 (4.7%) had an Apgar score lower than 7 and a low UA-pH. Infants with an Apgar score lower than 7 had a higher frequency of the combined outcome among those with a normal UA-pH (270 [48.4%] vs 596 [19.5%]) and a low UA-pH (108 [55.1%] vs 596 [19.5%]), with similar adjusted RRs (ARRs; low: 1.4 [95% CI, 1.2-1.7]; normal: 1.4 [95% CI, 1.3-1.6]). For mortality risk, associations were robust for an Apgar score lower than 7 and a low UA-pH (ARR, 2.4; 95% CI, 1.7-3.3) and absent with an Apgar score of 7 or higher and a low UA-pH (ARR, 1.2; 95% CI, 0.8-1.8). IVH risk was increased in all 3 subcategories, including an Apgar score of 7 or higher with a low UA-pH (ARR, 2.0","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2557913"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.58087
Kristen Apolinario, M Muska Nataliansyah, Krista L Haines, Patrick Murphy, Sarada Rao, Marc de Moya, Maddie R Rundell, Amir N Farah, Staci Young, Shelly D Timmons, Rachel S Morris
Importance: The Glasgow Outcome Scale-Extended (GOS-E), Quality of Life After Brain Injury-Overall Scale (QOLIBRI-OS), and Patient Health Questionnaire-9 (PHQ-9) are commonly used to evaluate recovery after traumatic brain injury (TBI), but they may not fully reflect the lived experiences of older adults (≥65 years). As the population of older adult survivors of TBI grows, understanding the factors that shape recovery becomes increasingly important.
Objective: To explore how older adults adapt to life in the first year after TBI and whether qualitative analysis of patient and caregiver interviews identifies aspects of recovery not captured by conventional outcome measures.
Design, setting, and participants: This qualitative study used multiple-methods combining standardized surveys and semistructured interviews and was conducted from October 2023 to January 2025 at a level I trauma center in the US. Adults aged 65 years and older hospitalized for TBI were recruited through the institutional trauma registry and interviewed approximately 1 year after hospitalization. Patients with cognitive limitations could participate if a consenting caregiver proxy was available. Recruitment continued until theoretical saturation.
Main outcomes and measures: The primary outcome was qualitative findings from thematic analysis of semistructured interviews. Secondary outcomes were health-related quality of life (QOLIBRI-OS); scale of 0 to 100 with higher scores indicating better perceived quality of life, functional status (GOS-E); scale of 8 levels with higher levels indicating good recovery, and depressive symptoms (PHQ-9); scale of 0 to 27 with higher scores indicating severe depression.
Results: A total of 29 patients (12 [41.4%] female; mean [SD] age, 77.4 [7.2] years) and 13 caregivers participated in interviews and surveys, with 21 (73%) classified as having good recovery on GOS-E. Mean (SD) QOLIBRI-OS score was 70.1 (18.8), and median (IQR) PHQ-9 score was 4 (1-6). Three themes emerged from analysis of interviews: (1) influence of support systems on independence and quality of life; (2) adapting to postinjury life through grief, acceptance, and gratitude; and (3) desire for more information and guidance on life postinjury.
Conclusions and relevance: In this study, older adults and their caregivers reported that their post-TBI recovery was impacted by physical and emotional adaptation, caregiving dynamics, and understanding of their clinical course-factors not entirely reflected in standard outcome scales. These findings suggest that clear discharge counseling, structured caregiver education to maximize safety and independence, and regular follow-up could improve quality of life for older adults post-TBI.
{"title":"Quality of Life Following Traumatic Brain Injury Among Older Adults.","authors":"Kristen Apolinario, M Muska Nataliansyah, Krista L Haines, Patrick Murphy, Sarada Rao, Marc de Moya, Maddie R Rundell, Amir N Farah, Staci Young, Shelly D Timmons, Rachel S Morris","doi":"10.1001/jamanetworkopen.2025.58087","DOIUrl":"10.1001/jamanetworkopen.2025.58087","url":null,"abstract":"<p><strong>Importance: </strong>The Glasgow Outcome Scale-Extended (GOS-E), Quality of Life After Brain Injury-Overall Scale (QOLIBRI-OS), and Patient Health Questionnaire-9 (PHQ-9) are commonly used to evaluate recovery after traumatic brain injury (TBI), but they may not fully reflect the lived experiences of older adults (≥65 years). As the population of older adult survivors of TBI grows, understanding the factors that shape recovery becomes increasingly important.</p><p><strong>Objective: </strong>To explore how older adults adapt to life in the first year after TBI and whether qualitative analysis of patient and caregiver interviews identifies aspects of recovery not captured by conventional outcome measures.</p><p><strong>Design, setting, and participants: </strong>This qualitative study used multiple-methods combining standardized surveys and semistructured interviews and was conducted from October 2023 to January 2025 at a level I trauma center in the US. Adults aged 65 years and older hospitalized for TBI were recruited through the institutional trauma registry and interviewed approximately 1 year after hospitalization. Patients with cognitive limitations could participate if a consenting caregiver proxy was available. Recruitment continued until theoretical saturation.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was qualitative findings from thematic analysis of semistructured interviews. Secondary outcomes were health-related quality of life (QOLIBRI-OS); scale of 0 to 100 with higher scores indicating better perceived quality of life, functional status (GOS-E); scale of 8 levels with higher levels indicating good recovery, and depressive symptoms (PHQ-9); scale of 0 to 27 with higher scores indicating severe depression.</p><p><strong>Results: </strong>A total of 29 patients (12 [41.4%] female; mean [SD] age, 77.4 [7.2] years) and 13 caregivers participated in interviews and surveys, with 21 (73%) classified as having good recovery on GOS-E. Mean (SD) QOLIBRI-OS score was 70.1 (18.8), and median (IQR) PHQ-9 score was 4 (1-6). Three themes emerged from analysis of interviews: (1) influence of support systems on independence and quality of life; (2) adapting to postinjury life through grief, acceptance, and gratitude; and (3) desire for more information and guidance on life postinjury.</p><p><strong>Conclusions and relevance: </strong>In this study, older adults and their caregivers reported that their post-TBI recovery was impacted by physical and emotional adaptation, caregiving dynamics, and understanding of their clinical course-factors not entirely reflected in standard outcome scales. These findings suggest that clear discharge counseling, structured caregiver education to maximize safety and independence, and regular follow-up could improve quality of life for older adults post-TBI.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2558087"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.59113
Shelly L Gray, Onchee Yu, Nicole M Gatto, Zachary A Marcum, Caitlin S Latimer, Nadia Postupna, Yu-Ru Su, Douglas Barthold, Jan Willem van Dalen, Edo Richard, C Dirk Keene, Pamela A Shaw, Linda K McEvoy, Eric B Larson, Paul K Crane
<p><strong>Importance: </strong>Antihypertensive medications that stimulate angiotensin II type 2 or 4 receptors (angiotensin II-stimulating medications) may be associated with lower risk of dementia.</p><p><strong>Objective: </strong>To examine associations between cumulative exposure to angiotensin II-stimulating vs angiotensin II-inhibiting antihypertensive medications and neuropathology, accounting for blood pressure.</p><p><strong>Design, setting, and participants: </strong>This community-based autopsy cohort study from the Adult Changes in Thought cohort was conducted at Kaiser Permanente Washington between February 24, 1994, and November 25, 2022, among 756 participants who had blood pressure measurements and at least 1 person-year (PY) of angiotensin II-stimulating or -inhibiting antihypertensive medication exposure prior to death. Statistical analysis was performed between September 2024 and August 2025.</p><p><strong>Exposure: </strong>Angiotensin II-stimulating antihypertensive medications (angiotensin II receptor blockers, dihydropyridine calcium channel blockers, thiazides) and angiotensin II-inhibiting antihypertensive medications (angiotensin-converting enzyme inhibitors, β-blockers, nondihydropyridine calcium channel blockers) were ascertained from paper-based medical records (before 1977) and electronic prescription fill data (after 1977). The primary exposure was cumulative angiotensin II PYs, and the secondary exposure was long-term use (≥15 years).</p><p><strong>Main outcomes and measures: </strong>Neuropathology outcomes were classified as Alzheimer disease related, vascular brain injury, or other. Exploratory outcomes included quantitative measures of Aβ42 and phosphorylated tau. Data were analyzed using multivariable modified Poisson, proportional odds, and linear regression models and accounted for potential selection bias.</p><p><strong>Results: </strong>The sample included 756 participants (mean [SD] age at death, 89.2 [6.4] years; 440 women [58.2%]; mean [SD] follow-up, 22.2 [13.5] years). Compared with exposure to 5 additional PYs of angiotensin II-inhibiting antihypertensive medications, exposure to 5 additional PYs of angiotensin II-stimulating antihypertensive medications was associated with a 6% lower risk for arteriolosclerosis (relative risk [RR], 0.94; 95% CI, 0.89-0.99), with long-term use associated with a 24% lower risk (RR, 0.76; 95% CI, 0.63-0.91). For exploratory outcomes, PYs of angiotensin II-stimulating antihypertensive medications were associated with less quantitative phosphorylated tau burden in several brain regions (temporal lobe [adjusted ratio of geometric means, 0.79; 95% CI, 0.62-1.00], hippocampus [adjusted ratio of geometric means, 0.83; 95% CI, 0.71-0.97], cornu ammonis subfield 1 [adjusted ratio of geometric means, 0.86; 95% CI, 0.74-0.99], and transentorhinal cortex [adjusted ratio of geometric means, 0.83; 95% CI, 0.70-0.98]) but not with Aβ42 quantitative measures.</p><p><strong>Conclusi
{"title":"Angiotensin II-Stimulating Antihypertensive Medications and Dementia-Related Neuropathology.","authors":"Shelly L Gray, Onchee Yu, Nicole M Gatto, Zachary A Marcum, Caitlin S Latimer, Nadia Postupna, Yu-Ru Su, Douglas Barthold, Jan Willem van Dalen, Edo Richard, C Dirk Keene, Pamela A Shaw, Linda K McEvoy, Eric B Larson, Paul K Crane","doi":"10.1001/jamanetworkopen.2025.59113","DOIUrl":"10.1001/jamanetworkopen.2025.59113","url":null,"abstract":"<p><strong>Importance: </strong>Antihypertensive medications that stimulate angiotensin II type 2 or 4 receptors (angiotensin II-stimulating medications) may be associated with lower risk of dementia.</p><p><strong>Objective: </strong>To examine associations between cumulative exposure to angiotensin II-stimulating vs angiotensin II-inhibiting antihypertensive medications and neuropathology, accounting for blood pressure.</p><p><strong>Design, setting, and participants: </strong>This community-based autopsy cohort study from the Adult Changes in Thought cohort was conducted at Kaiser Permanente Washington between February 24, 1994, and November 25, 2022, among 756 participants who had blood pressure measurements and at least 1 person-year (PY) of angiotensin II-stimulating or -inhibiting antihypertensive medication exposure prior to death. Statistical analysis was performed between September 2024 and August 2025.</p><p><strong>Exposure: </strong>Angiotensin II-stimulating antihypertensive medications (angiotensin II receptor blockers, dihydropyridine calcium channel blockers, thiazides) and angiotensin II-inhibiting antihypertensive medications (angiotensin-converting enzyme inhibitors, β-blockers, nondihydropyridine calcium channel blockers) were ascertained from paper-based medical records (before 1977) and electronic prescription fill data (after 1977). The primary exposure was cumulative angiotensin II PYs, and the secondary exposure was long-term use (≥15 years).</p><p><strong>Main outcomes and measures: </strong>Neuropathology outcomes were classified as Alzheimer disease related, vascular brain injury, or other. Exploratory outcomes included quantitative measures of Aβ42 and phosphorylated tau. Data were analyzed using multivariable modified Poisson, proportional odds, and linear regression models and accounted for potential selection bias.</p><p><strong>Results: </strong>The sample included 756 participants (mean [SD] age at death, 89.2 [6.4] years; 440 women [58.2%]; mean [SD] follow-up, 22.2 [13.5] years). Compared with exposure to 5 additional PYs of angiotensin II-inhibiting antihypertensive medications, exposure to 5 additional PYs of angiotensin II-stimulating antihypertensive medications was associated with a 6% lower risk for arteriolosclerosis (relative risk [RR], 0.94; 95% CI, 0.89-0.99), with long-term use associated with a 24% lower risk (RR, 0.76; 95% CI, 0.63-0.91). For exploratory outcomes, PYs of angiotensin II-stimulating antihypertensive medications were associated with less quantitative phosphorylated tau burden in several brain regions (temporal lobe [adjusted ratio of geometric means, 0.79; 95% CI, 0.62-1.00], hippocampus [adjusted ratio of geometric means, 0.83; 95% CI, 0.71-0.97], cornu ammonis subfield 1 [adjusted ratio of geometric means, 0.86; 95% CI, 0.74-0.99], and transentorhinal cortex [adjusted ratio of geometric means, 0.83; 95% CI, 0.70-0.98]) but not with Aβ42 quantitative measures.</p><p><strong>Conclusi","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2559113"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.58865
Troy Leo, James Reynolds, Joshua Blair, Allyn Abadie, Elizabeth Euiler, Kevin Aubol, Wayne Sotile, Stephanie O'Bryon, Jeremiah Gaddy, Kevin W Lobdell, Geoffrey A Rose
<p><strong>Importance: </strong>The demands of clinical practice have contributed to widespread burnout among health care professionals. Thus, there is an urgent need for scalable and evidence-based interventions to address burnout in this population.</p><p><strong>Objective: </strong>To assess whether participation in an asynchronous, app-based, personalized coaching intervention informed by biometric data is associated with changes in burnout, professional fulfillment, and self-valuation among health care professionals.</p><p><strong>Design, setting, and participants: </strong>This prospective cohort study was conducted at a large health care system (Advocate Health) in the US. Clinicians and other health care professionals from 4 service lines (critical care, women's health, heart and vascular, and emergency medicine) were recruited between June 14 and August 12, 2024. Between August 27 and October 22, 2024, participants completed assessments at baseline and 8 weeks. Those who completed assessments at both baseline and 8 weeks were included in this study. Analysis was completed in November 2024 and April 2025.</p><p><strong>Exposure: </strong>An 8-week asynchronous app-based coaching program integrated with a wearable photoplethysmography sensor.</p><p><strong>Main outcomes and measures: </strong>The primary outcome assessed was the change from baseline to week 8 in scores on Stanford Professional Fulfillment Index (PFI) domains (burnout, professional fulfillment, and self-valuation) and on Maslach Burnout Inventory Human Services Survey (MBI-HSS) subscales (emotional exhaustion, depersonalization, and personal accomplishment). For each outcome, linear mixed-effects models were used with restricted maximum likelihood.</p><p><strong>Results: </strong>A total of 367 clinicians and other health care professionals completed baseline assessments. Of these, 192 (52.3%) completed assessments at both baseline and 8 weeks and were included in this study. Their mean (SD) age was 42.5 (10.0) years, and most (135 [70.3%]) were female. The largest participant groups were attending physicians (92 [47.9%]), advanced practice clinicians (47 [24.5%]), and nurses (37 [19.3%]). For the PFI domains, the mean (SD) professional fulfillment score increased from 2.36 (0.68) to 2.56 (0.76) (change, 0.20 [95% CI, 0.12 to 0.28] points; P < .001), the mean (SD) burnout score decreased from 1.60 (0.71) to 1.09 (0.62) (change, -0.51 [95% CI, -0.60 to -0.43] points; P < .001), and the mean (SD) self-valuation score increased from 6.47 (3.00) to 9.02 (2.75) (change, 2.55 [95% CI, 2.12 to 2.98] points; P < .001). For the MBI-HSS subscales, the mean (SD) emotional exhaustion score decreased from 19.74 (8.95) to 15.68 (8.59) (change, -4.06 [95% CI, -5.10 to -3.03] points; P < .001), the mean (SD) depersonalization score decreased from 14.58 (8.50) to 10.32 (7.19) (change, -4.26 [95% CI, -5.26 to -3.27] points; P < .001), and the mean (SD) personal accomplishment score increased
{"title":"Assessment of Clinician Well-Being Using a Biometric-Informed Coaching Platform.","authors":"Troy Leo, James Reynolds, Joshua Blair, Allyn Abadie, Elizabeth Euiler, Kevin Aubol, Wayne Sotile, Stephanie O'Bryon, Jeremiah Gaddy, Kevin W Lobdell, Geoffrey A Rose","doi":"10.1001/jamanetworkopen.2025.58865","DOIUrl":"10.1001/jamanetworkopen.2025.58865","url":null,"abstract":"<p><strong>Importance: </strong>The demands of clinical practice have contributed to widespread burnout among health care professionals. Thus, there is an urgent need for scalable and evidence-based interventions to address burnout in this population.</p><p><strong>Objective: </strong>To assess whether participation in an asynchronous, app-based, personalized coaching intervention informed by biometric data is associated with changes in burnout, professional fulfillment, and self-valuation among health care professionals.</p><p><strong>Design, setting, and participants: </strong>This prospective cohort study was conducted at a large health care system (Advocate Health) in the US. Clinicians and other health care professionals from 4 service lines (critical care, women's health, heart and vascular, and emergency medicine) were recruited between June 14 and August 12, 2024. Between August 27 and October 22, 2024, participants completed assessments at baseline and 8 weeks. Those who completed assessments at both baseline and 8 weeks were included in this study. Analysis was completed in November 2024 and April 2025.</p><p><strong>Exposure: </strong>An 8-week asynchronous app-based coaching program integrated with a wearable photoplethysmography sensor.</p><p><strong>Main outcomes and measures: </strong>The primary outcome assessed was the change from baseline to week 8 in scores on Stanford Professional Fulfillment Index (PFI) domains (burnout, professional fulfillment, and self-valuation) and on Maslach Burnout Inventory Human Services Survey (MBI-HSS) subscales (emotional exhaustion, depersonalization, and personal accomplishment). For each outcome, linear mixed-effects models were used with restricted maximum likelihood.</p><p><strong>Results: </strong>A total of 367 clinicians and other health care professionals completed baseline assessments. Of these, 192 (52.3%) completed assessments at both baseline and 8 weeks and were included in this study. Their mean (SD) age was 42.5 (10.0) years, and most (135 [70.3%]) were female. The largest participant groups were attending physicians (92 [47.9%]), advanced practice clinicians (47 [24.5%]), and nurses (37 [19.3%]). For the PFI domains, the mean (SD) professional fulfillment score increased from 2.36 (0.68) to 2.56 (0.76) (change, 0.20 [95% CI, 0.12 to 0.28] points; P < .001), the mean (SD) burnout score decreased from 1.60 (0.71) to 1.09 (0.62) (change, -0.51 [95% CI, -0.60 to -0.43] points; P < .001), and the mean (SD) self-valuation score increased from 6.47 (3.00) to 9.02 (2.75) (change, 2.55 [95% CI, 2.12 to 2.98] points; P < .001). For the MBI-HSS subscales, the mean (SD) emotional exhaustion score decreased from 19.74 (8.95) to 15.68 (8.59) (change, -4.06 [95% CI, -5.10 to -3.03] points; P < .001), the mean (SD) depersonalization score decreased from 14.58 (8.50) to 10.32 (7.19) (change, -4.26 [95% CI, -5.26 to -3.27] points; P < .001), and the mean (SD) personal accomplishment score increased","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2558865"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12895280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-02DOI: 10.1001/jamanetworkopen.2025.56971
Erika Rees-Punia, Lauren R Teras, Christina C Newton, Steven C Moore, I-Min Lee, Lauren Bates-Fraser, Kathryn E Chiang, Den E Bloodworth, A Heather Eliassen, Lorelei Mucci, Brigid M Lynch, Meir Stampfer, Mingyang Song, Kristen D Brantley, Konrad H Stopsack, Charles E Matthews, Alpa V Patel
<p><strong>Importance: </strong>There is insufficient evidence to determine whether physical activity lengthens survival among people with a history of cancers less commonly studied for such benefit.</p><p><strong>Objective: </strong>To examine the associations between physical activity assessed after a cancer diagnosis with cancer mortality and, secondarily, changes in physical activity before vs after diagnosis with cancer mortality among people previously diagnosed with 1 of 7 cancers.</p><p><strong>Design, setting, and participants: </strong>This study used a pooled dataset of 6 cohorts (Cancer Prevention Study-II Nutrition Cohort, Health Professionals Follow-Up Study, National Institutes of Health-AARP Diet and Health Study, Nurses' Health Study, Nurses' Health Study II, and Women's Health Study). Participants were survivors of bladder, endometrial, kidney, lung, oral cavity, ovarian, or rectal cancer who had completed surveys and had repeated measures of leisure-time physical activity. Baseline data were collected from 1976 through 1997. The mean (SD) follow-up was 10.9 (7.0) years. Data were analyzed from June 2023 to March 2024.</p><p><strong>Exposures: </strong>Leisure-time moderate to vigorous physical activity (MVPA) before and after cancer diagnosis.</p><p><strong>Main outcomes and measures: </strong>Association of MVPA in categories of metabolic equivalents of task hours per week (MET-h/wk) measured before and a mean (SD) of 2.8 (1.5) years after cancer diagnosis with cancer mortality.</p><p><strong>Results: </strong>This pooled analysis included 17 141 cancer survivors (mean [SD] age, 67 [8] years; 60% female). Engagement in low amounts of MVPA (>0 to <7.5 vs 0 MET-h/wk) was associated with lower risk of cancer mortality among survivors who had been diagnosed with bladder (hazard ratio [HR], 0.67 [95% CI, 0.50-0.91]), endometrial (HR, 0.62 [95% CI, 0.45-0.87]), and lung cancer (HR, 0.56 [95% CI, 0.43-0.75]). Doubling the recommended MVPA guideline or more (eg, >15 vs 0 MET-h/wk) was associated with lower risk of cancer mortality among oral (HR, 0.39 [95% CI, 0.15-0.99] for >22.5 to 30.0 MET-h/wk) and rectal (HR, 0.57 [95% CI, 0.33-0.97] for >15.0 to 22.5 MET-h/wk) cancer survivors. Point estimates were less than 1 for cancer mortality among kidney cancer survivors (HR, 0.51 [95% CI, 0.22-1.18] for >15.0 to 22.5 MET-h/wk), although the confidence interval included the null. Compared with survivors who did not meet the MVPA guidelines before or after diagnosis, lung (HR, 0.58 [95% CI, 0.47-0.71]) and rectal (HR, 0.51 [95% CI, 0.32-0.83]) cancer survivors who met guidelines after diagnosis had a lower risk of cancer mortality, even if they were inactive before their diagnosis.</p><p><strong>Conclusions and relevance: </strong>In this analysis of 6 pooled cohorts, higher levels of MVPA after a cancer diagnosis were associated with lower risk of cancer mortality among people previously diagnosed with 1 of 7 cancers not commonly studied f
{"title":"Leisure-Time Physical Activity and Cancer Mortality Among Cancer Survivors.","authors":"Erika Rees-Punia, Lauren R Teras, Christina C Newton, Steven C Moore, I-Min Lee, Lauren Bates-Fraser, Kathryn E Chiang, Den E Bloodworth, A Heather Eliassen, Lorelei Mucci, Brigid M Lynch, Meir Stampfer, Mingyang Song, Kristen D Brantley, Konrad H Stopsack, Charles E Matthews, Alpa V Patel","doi":"10.1001/jamanetworkopen.2025.56971","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.56971","url":null,"abstract":"<p><strong>Importance: </strong>There is insufficient evidence to determine whether physical activity lengthens survival among people with a history of cancers less commonly studied for such benefit.</p><p><strong>Objective: </strong>To examine the associations between physical activity assessed after a cancer diagnosis with cancer mortality and, secondarily, changes in physical activity before vs after diagnosis with cancer mortality among people previously diagnosed with 1 of 7 cancers.</p><p><strong>Design, setting, and participants: </strong>This study used a pooled dataset of 6 cohorts (Cancer Prevention Study-II Nutrition Cohort, Health Professionals Follow-Up Study, National Institutes of Health-AARP Diet and Health Study, Nurses' Health Study, Nurses' Health Study II, and Women's Health Study). Participants were survivors of bladder, endometrial, kidney, lung, oral cavity, ovarian, or rectal cancer who had completed surveys and had repeated measures of leisure-time physical activity. Baseline data were collected from 1976 through 1997. The mean (SD) follow-up was 10.9 (7.0) years. Data were analyzed from June 2023 to March 2024.</p><p><strong>Exposures: </strong>Leisure-time moderate to vigorous physical activity (MVPA) before and after cancer diagnosis.</p><p><strong>Main outcomes and measures: </strong>Association of MVPA in categories of metabolic equivalents of task hours per week (MET-h/wk) measured before and a mean (SD) of 2.8 (1.5) years after cancer diagnosis with cancer mortality.</p><p><strong>Results: </strong>This pooled analysis included 17 141 cancer survivors (mean [SD] age, 67 [8] years; 60% female). Engagement in low amounts of MVPA (>0 to <7.5 vs 0 MET-h/wk) was associated with lower risk of cancer mortality among survivors who had been diagnosed with bladder (hazard ratio [HR], 0.67 [95% CI, 0.50-0.91]), endometrial (HR, 0.62 [95% CI, 0.45-0.87]), and lung cancer (HR, 0.56 [95% CI, 0.43-0.75]). Doubling the recommended MVPA guideline or more (eg, >15 vs 0 MET-h/wk) was associated with lower risk of cancer mortality among oral (HR, 0.39 [95% CI, 0.15-0.99] for >22.5 to 30.0 MET-h/wk) and rectal (HR, 0.57 [95% CI, 0.33-0.97] for >15.0 to 22.5 MET-h/wk) cancer survivors. Point estimates were less than 1 for cancer mortality among kidney cancer survivors (HR, 0.51 [95% CI, 0.22-1.18] for >15.0 to 22.5 MET-h/wk), although the confidence interval included the null. Compared with survivors who did not meet the MVPA guidelines before or after diagnosis, lung (HR, 0.58 [95% CI, 0.47-0.71]) and rectal (HR, 0.51 [95% CI, 0.32-0.83]) cancer survivors who met guidelines after diagnosis had a lower risk of cancer mortality, even if they were inactive before their diagnosis.</p><p><strong>Conclusions and relevance: </strong>In this analysis of 6 pooled cohorts, higher levels of MVPA after a cancer diagnosis were associated with lower risk of cancer mortality among people previously diagnosed with 1 of 7 cancers not commonly studied f","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 2","pages":"e2556971"},"PeriodicalIF":9.7,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}