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Atopic Dermatitis and Markers of Early Cardiovascular Risk in Children and Adolescents. 儿童和青少年的特应性皮炎和早期心血管危险标志物。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.2962
Morgan Ye, Charles E McCulloch, Carlos Iribarren, Sinéad M Langan, Katrina Abuabara
<p><strong>Importance: </strong>Early identification of individuals at elevated risk of cardiovascular disease and preventive treatment during childhood may reduce cardiovascular disease in adults with chronic inflammatory diseases. Children with atopic dermatitis (AD) may have elevated cardiovascular risk, but studies to date have not accounted for heterogeneity in disease activity and severity across childhood.</p><p><strong>Objectives: </strong>To evaluate whether active and more severe AD across childhood and adolescence are associated with cardiovascular risk.</p><p><strong>Design, setting, and participants: </strong>This longitudinal cohort study used data collected from 1991 to 2017 for the Avon Longitudinal Study of Parents and Children, a population-based birth cohort in the United Kingdom. Participants included children alive at 1 year with assessment of AD and at least 1 cardiovascular disease risk factor at a minimum of 1 time point. Data were analyzed November 30, 2022, to February 20, 2025.</p><p><strong>Exposures: </strong>Repeated assessments of AD activity and severity across childhood and adolescence.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was cardiometabolic risk scores calculated at ages 15, 17, and 24 years. Secondary outcomes included body mass index, blood pressure, and lipid profiles measured up to 12 times between ages 3 and 24 years and ultrasonography measures of subclinical atherosclerosis at ages 17 and 24 years.</p><p><strong>Results: </strong>The subcohort included 9281 children, of whom 4669 (50.31%) were male. The analysis included 1001 participants (10.79%) 3 years of age, 908 (9.78%) 4 years, 838 (9.03%) 5 years, 6352 (68.44%) 7 years, 6205 (66.86%) 10 years, 5629 (60.65%) 11 years, 4968 (53.53%) 13 years, 3502 (37.73%) 15 years, 4738 (51.05%) 17 years, and 3626 (39.07%) 24 years of age. The prevalence of active AD varied by age and ranged from 13.10% to 21.58% at ages 3 through 18 years. Among participants with AD, 3.52% to 6.85% reported moderate or severe disease at each age. Multivariable linear regression models did not reveal associations between active AD and most cardiovascular risk factors; only 2 associations between AD and low-density lipoprotein cholesterol levels were found with P < .05, but they differed in the directionality of association at ages 3 and 10 years (mean difference, -0.33 [95% CI, -0.58 to -0.07] SDs for 3 years vs 0.14 [95% CI, 0.03-0.24] SDs at 10 years). There was no consistent evidence for dose-response effects by AD severity. There were also no associations between patterns of more active and severe AD across childhood with subclinical atherosclerosis.</p><p><strong>Conclusions and relevance: </strong>In a population-based UK cohort of children and adolescents followed up into early adulthood, AD, including more active and severe disease over time, was not associated with increases in markers of cardiovascular risk. This finding suggests that syst
重要性:早期识别心血管疾病高危人群并在儿童期进行预防性治疗,可能会减少患有慢性炎症性疾病的成人的心血管疾病。患有特应性皮炎(AD)的儿童可能有较高的心血管风险,但迄今为止的研究尚未说明儿童时期疾病活动性和严重程度的异质性。目的:评估儿童期和青春期活动性和更严重的AD是否与心血管风险相关。设计、环境和参与者:这项纵向队列研究使用了1991年至2017年收集的数据,这些数据来自英国以人口为基础的出生队列——雅芳父母和儿童纵向研究。参与者包括在至少1个时间点评估AD和至少1种心血管疾病危险因素的1岁存活儿童。数据分析时间为2022年11月30日至2025年2月20日。暴露:对童年和青春期AD活动和严重程度的反复评估。主要结局和测量:主要结局是在15岁、17岁和24岁时计算的心脏代谢风险评分。次要结局包括体重指数、血压和血脂在3岁至24岁之间测量多达12次,以及在17岁至24岁时亚临床动脉粥样硬化的超声测量。结果:该亚队列包括9281名儿童,其中4669名(50.31%)为男性。共纳入3岁1001人(10.79%)、4岁908人(9.78%)、5岁838人(9.03%)、7岁6352人(68.44%)、10岁6205人(66.86%)、11岁5629人(60.65%)、13岁4968人(53.53%)、15岁3502人(37.73%)、17岁4738人(51.05%)、24岁3626人(39.07%)。活动性阿尔茨海默病的患病率因年龄而异,3至18岁的患病率从13.10%到21.58%不等。在AD患者中,3.52%至6.85%在每个年龄段报告中度或重度疾病。多变量线性回归模型并未揭示活动性AD与大多数心血管危险因素之间的关联;结论和相关性:在一项以人群为基础的英国儿童和青少年队列中,随着时间的推移,AD(包括更活跃和严重的疾病)与心血管风险标志物的增加无关。这一发现表明,对所有AD患儿进行系统筛查不太可能提高对早期心血管风险的识别。
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引用次数: 0
Extreme Urban Heat and Emergency Department Visits in Older Adults. 城市高温和老年人急诊科就诊。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.2645
Evan Siau, Genevieve S Silva, Jeremy Lu, Cassandra Thiel, Simon Jones, Leora I Horwitz, Katie E Lichter, Alexander Azan
<p><strong>Importance: </strong>Health care systems can help protect patients from the increasing threat of extreme heat-driven morbidity and mortality. Electronic health records (EHRs) provide insight into trends and local variation in thresholds above which extreme heat is associated with emergency department (ED) use among at-risk patient populations.</p><p><strong>Objective: </strong>To examine associations between extreme heat exposure and all-cause ED visits among patients aged 65 years and older.</p><p><strong>Design, setting, and participants: </strong>This matched case-control study of patients seeking emergency care at an urban health care system during the summer (May 1 to September 30) from 2022 to 2024. Two New York City (NYC) EDs were included: (1) ED-1, predominantly serving Medicaid-enrolled patients from minoritized racial and ethnic groups, and (2) ED-2, predominantly serving White, privately insured patients. Included patients were aged 65 years or older and presented to ED-1 and ED-2 during the study period. Data were analyzed from April to August 2025.</p><p><strong>Exposures: </strong>Daily maximum heat index (HImax) values during the summer were calculated from the National Centers for Environmental Information monitor-derived recordings.</p><p><strong>Main outcomes and measures: </strong>Daily all-cause ED use counts were derived from EHRs, and extreme heat exposure-outcome curves were calculated. Daily HImax anomalies were calculated based on a 30-year baseline average. The cumulative odds ratio (OR) and 95% CIs were calculated.</p><p><strong>Results: </strong>This study included 55 200 ED encounters and represented 15 092 unique patients at ED-1 and 19 559 at ED-2 with a mean (SD) age of 74.9 (8.92) years at ED-1 and 74.9 (8.72) years at ED-2. Compared with ED-2, more ED-1 patients were female (8589 [56.9%] vs 10 767 [55.0%]), Hispanic (3544 [23.5%] vs 2576 [13.2%]), and Medicaid-enrolled (1321 [8.8%] vs 824 [4.2%]). At ED-1, daily HImax associations increased after 66 °F (OR, 1.10 [95% CI, 1.01-1.21]), peaking at 101 °F (OR, 1.24 [95% CI, 1.11-1.39]), and were higher on days with HImax anomalies between 15 °F (OR, 1.07 [95% CI, 1.01-1.13]) and 18 °F (OR, 1.10 [95% CI, 1.01-1.20]) warmer than average. At ED-2, daily HImax ED use associations were not significant and were significantly negative for days with HImax anomalies above 16 °F, nadiring at 21 °F (0.84, 95% CI [0.73, 0.95]) warmer than average.</p><p><strong>Conclusions and relevance: </strong>In this case-control study of the association between heat exposure and ED use in adults aged 65 years and older, positive associations were only observed at ED-1, which served a predominantly lower-income population from minoritized racial and ethnic groups. These association thresholds were not fully captured by NYC heat advisories, which were triggered by 2 days above HImax 95 °F or any time above 100 °F, highlighting an opportunity for future research to develop targeted
重要性:卫生保健系统可以帮助保护患者免受极端高温导致的发病率和死亡率日益增加的威胁。电子健康记录(EHRs)提供了对极端高温与高危患者使用急诊科(ED)相关阈值的趋势和局部变化的洞察。目的:研究65岁及以上患者的极端高温暴露与全因ED就诊之间的关系。设计、环境和参与者:这是一项匹配的病例对照研究,研究对象是2022年至2024年夏季(5月1日至9月30日)在城市卫生保健系统寻求急诊护理的患者。纽约市(NYC)的两家急诊室包括:(1)ED-1,主要服务于少数种族和族裔群体的医疗补助登记患者;(2)ED-2,主要服务于私人保险的白人患者。纳入的患者年龄在65岁或以上,在研究期间出现ED-1和ED-2。数据分析时间为2025年4月至8月。暴露:夏季每日最高热指数(HImax)值是根据国家环境信息中心的监测记录计算的。主要结果和测量:每日全因ED使用计数来自电子病历,并计算极端热暴露-结果曲线。日HImax距平是根据30年基线平均值计算的。计算累积优势比(OR)和95% ci。结果:本研究包括55 200例ED就诊,ED-1患者15 092例,ED-2患者19 559例,ED-1患者平均(SD)年龄为74.9(8.92)岁,ED-2患者平均(SD)年龄为74.9(8.72)岁。与ED-2相比,ED-1患者更多的是女性(8589例[56.9%]vs 10例 767例[55.0%])、西班牙裔(3544例[23.5%]vs 2576例[13.2%])和参加医疗补助(1321例[8.8%]vs 824例[4.2%])。在ED-1,每日HImax相关性在66°F (OR, 1.10 [95% CI, 1.01-1.21])后增加,在101°F (OR, 1.24 [95% CI, 1.11-1.39])时达到峰值,并且在HImax异常在15°F (OR, 1.07 [95% CI, 1.01-1.13])和18°F (OR, 1.10 [95% CI, 1.01-1.20])时高于平均温度。在ED-2时,每日HImax ED使用关联不显著,并且在HImax异常高于16°F的天数中呈显著负相关,最低为比平均温度高21°F (0.84, 95% CI[0.73, 0.95])。结论和相关性:在这项关于65岁及以上成年人热暴露与ED使用之间关系的病例对照研究中,仅在ED-1阶段观察到正相关,ED-1主要服务于少数种族和族裔群体的低收入人群。这些关联阈值并没有被纽约市的高温预警完全捕获,这些预警是在超过最高95华氏度的2天或超过100华氏度的任何时间触发的,这突出了未来研究的机会,即制定有针对性的、风险信息充足的基于卫生保健系统的高温预警策略。
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引用次数: 0
Smartphone Use During School Hours and Association With Cognitive Control in Youths Aged 11 to 18 Years. 11至18岁青少年在校期间使用智能手机与认知控制的关系
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.1092
Eva H Telzer, Kaitlyn Burnell

Importance: Smartphones are a pervasive feature of adolescents' daily lives, raising concern about how smartphones are used in contexts such as school that require sustained attention and self-regulation.

Objectives: To describe youths' smartphone use during each hour of the school day and examine whether smartphone use during school is associated with poorer cognitive control, a key developmental process underlying academic success.

Design, setting, and participants: This cross-sectional study of youths aged 11 to 18 years from the Southeastern US objectively assessed smartphone use every hour for 14 consecutive days between April 8, 2021, and February 2, 2022 (cohort 1), and February 1, 2023, and December 11, 2024 (cohort 2), providing thousands of data points to capture actual engagement.

Main outcomes and measures: The iPhone iOS (Apple) screen time report captured smartphone use at every hour. Cognitive control was measured in the older cohort using a go/no-go task, with the signal detection metric d' quantifying inhibitory control.

Results: A total of 79 participants (mean [SD] age, 15.10 [2.04] years; 41 [51.9%] female) participated in the study. Youths were using their smartphones during every hour of the school day, spending a total of 2.22 hours of the school day on their smartphones. Youths aged 15 to 18 years spent more time on their smartphones during school hours than those aged 11 to 14 years (mean [SD], 23.28 [18.34] vs 11.57 [16.83] min/h; F1,76 = 28.82, P < .001, η2 = 0.28). Youths spent a mean (SD) of 40.14 (39.56) minutes on social media and 13.85 (25.22) minutes on entertainment apps during school hours. Youths checked their smartphones a mean (SD) of 64.46 (32.83) times during school hours. More frequent smartphone checking was associated with lower d' values (F1,28 = 4.8, P = .04, η2 = 0.15), indicating poorer cognitive control.

Conclusions and relevance: This cross-sectional study found that youths use smartphones approximately one-third of the school day; this use was associated with reduced cognitive control. These findings highlight the need for school-level policies and digital literacy programs that address not only overall screen time but also habitual smartphone-checking behaviors that fragment attention.

重要性:智能手机是青少年日常生活中普遍存在的特征,这引起了人们对智能手机在学校等需要持续关注和自我调节的环境中如何使用的担忧。目的:描述青少年在上学期间每小时的智能手机使用情况,并检查在学校使用智能手机是否与较差的认知控制有关,认知控制是学业成功的关键发展过程。设计、环境和参与者:这项针对美国东南部11至18岁青少年的横断面研究,客观评估了2021年4月8日至2022年2月2日(队列1)、2023年2月1日至2024年12月11日(队列2)之间连续14天每小时使用智能手机的情况,提供了数千个数据点来捕捉实际参与度。主要结果和衡量标准:iPhone iOS(苹果)的屏幕时间报告记录了每小时的智能手机使用情况。在老年队列中,使用go/no-go任务测量认知控制,并使用信号检测度量量化抑制控制。结果:共有79名参与者(平均[SD]年龄15.10[2.04]岁,女性41名[51.9%])参与研究。青少年在上学的每一个小时都在使用智能手机,在上学的一天里,他们花在智能手机上的时间总计为2.22小时。15 - 18岁的青少年在上学期间花在智能手机上的时间比11 - 14岁的青少年多(平均[SD], 23.28 [18.34] vs 11.57 [16.83] min/h; F1,76 = 28.82, P)。结论和相关性:这项横断面研究发现,青少年在上学期间大约三分之一的时间使用智能手机,这种使用与认知控制能力下降有关。这些发现强调了学校层面的政策和数字扫盲计划的必要性,这些政策和计划不仅要解决整体屏幕时间问题,还要解决习惯性查看智能手机的行为,这些行为会分散注意力。
{"title":"Smartphone Use During School Hours and Association With Cognitive Control in Youths Aged 11 to 18 Years.","authors":"Eva H Telzer, Kaitlyn Burnell","doi":"10.1001/jamanetworkopen.2026.1092","DOIUrl":"10.1001/jamanetworkopen.2026.1092","url":null,"abstract":"<p><strong>Importance: </strong>Smartphones are a pervasive feature of adolescents' daily lives, raising concern about how smartphones are used in contexts such as school that require sustained attention and self-regulation.</p><p><strong>Objectives: </strong>To describe youths' smartphone use during each hour of the school day and examine whether smartphone use during school is associated with poorer cognitive control, a key developmental process underlying academic success.</p><p><strong>Design, setting, and participants: </strong>This cross-sectional study of youths aged 11 to 18 years from the Southeastern US objectively assessed smartphone use every hour for 14 consecutive days between April 8, 2021, and February 2, 2022 (cohort 1), and February 1, 2023, and December 11, 2024 (cohort 2), providing thousands of data points to capture actual engagement.</p><p><strong>Main outcomes and measures: </strong>The iPhone iOS (Apple) screen time report captured smartphone use at every hour. Cognitive control was measured in the older cohort using a go/no-go task, with the signal detection metric d' quantifying inhibitory control.</p><p><strong>Results: </strong>A total of 79 participants (mean [SD] age, 15.10 [2.04] years; 41 [51.9%] female) participated in the study. Youths were using their smartphones during every hour of the school day, spending a total of 2.22 hours of the school day on their smartphones. Youths aged 15 to 18 years spent more time on their smartphones during school hours than those aged 11 to 14 years (mean [SD], 23.28 [18.34] vs 11.57 [16.83] min/h; F1,76 = 28.82, P < .001, η2 = 0.28). Youths spent a mean (SD) of 40.14 (39.56) minutes on social media and 13.85 (25.22) minutes on entertainment apps during school hours. Youths checked their smartphones a mean (SD) of 64.46 (32.83) times during school hours. More frequent smartphone checking was associated with lower d' values (F1,28 = 4.8, P = .04, η2 = 0.15), indicating poorer cognitive control.</p><p><strong>Conclusions and relevance: </strong>This cross-sectional study found that youths use smartphones approximately one-third of the school day; this use was associated with reduced cognitive control. These findings highlight the need for school-level policies and digital literacy programs that address not only overall screen time but also habitual smartphone-checking behaviors that fragment attention.</p>","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 3","pages":"e261092"},"PeriodicalIF":9.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collecting Social Determinants of Health in a Children's Oncology Group Trial for High-Risk Neuroblastoma. 收集高危神经母细胞瘤儿童肿瘤组试验中健康的社会决定因素
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.0419
Emily Jones, Arlene Naranjo, Lena E Winestone, Puja J Umaretiya, Rahela Aziz-Bose, Colleen A Kelly, Haley Newman, Daniel J Zheng, Emily Greengard, Rochelle Bagatell, Steven G DuBois, Kira Bona
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引用次数: 0
Rethinking the First Basic Steps of Newborn Care-Cold and Wet! 重新思考新生儿护理的第一个基本步骤——寒冷和潮湿!
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2025.56864
Anup C Katheria
{"title":"Rethinking the First Basic Steps of Newborn Care-Cold and Wet!","authors":"Anup C Katheria","doi":"10.1001/jamanetworkopen.2025.56864","DOIUrl":"https://doi.org/10.1001/jamanetworkopen.2025.56864","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 3","pages":"e2556864"},"PeriodicalIF":9.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Error in Byline. 署名错误。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.4615
{"title":"Error in Byline.","authors":"","doi":"10.1001/jamanetworkopen.2026.4615","DOIUrl":"10.1001/jamanetworkopen.2026.4615","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 3","pages":"e264615"},"PeriodicalIF":9.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Error in Figure. 图中出现错误。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.4708
{"title":"Error in Figure.","authors":"","doi":"10.1001/jamanetworkopen.2026.4708","DOIUrl":"10.1001/jamanetworkopen.2026.4708","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 3","pages":"e264708"},"PeriodicalIF":9.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Error in Affiliation. 关联错误。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.5103
{"title":"Error in Affiliation.","authors":"","doi":"10.1001/jamanetworkopen.2026.5103","DOIUrl":"10.1001/jamanetworkopen.2026.5103","url":null,"abstract":"","PeriodicalId":14694,"journal":{"name":"JAMA Network Open","volume":"9 3","pages":"e265103"},"PeriodicalIF":9.7,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Female Reproductive Cancers and the Sex Gap in Survival. 女性生殖癌症和生存中的性别差异。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.1256
Vladimir Canudas-Romo, Wen Su, Emily Banks, Sergey Timonin

Importance: On average, females live longer than males. Research on sex differences in longevity has traditionally focused on higher mortality among males; however, the contribution of female reproductive cancers to survival gaps between females and males remains insufficiently quantified.

Objective: To assess the female-to-male survival gaps by estimating the contribution of age, birth cohort, and cause of death to sex differences in survival, with a particular emphasis on female reproductive cancers-breast and gynecological cancers-in long-term longevity disparities.

Design, setting, and participants: This cohort study used population-level mortality data from 20 countries with complete records from 1955 to 2020 from the Human Mortality and World Health Organization Mortality Databases. Data were analyzed from January 2023 to September 2025.

Exposure: Geographic location (Australia, Austria, Belgium, Canada, Denmark, Finland, France, Hungary, Ireland, Italy, Japan, the Netherlands, New Zealand, Norway, Portugal, Spain, Sweden, Switzerland, the UK, and the US).

Main outcome and measures: The primary outcome was the truncated cross-sectional average length of life (TCAL), which incorporates historical mortality information for all birth cohorts alive at a given time. For each country, the sex gap in survival-measured as the difference in TCAL between females and males-was calculated, decomposed, and presented graphically by birth cohort, age, and calendar year.

Results: The analysis encompassed 264.4 million deaths from all causes (119.1 million female [45.1%]; 145.2 million male [54.9%]), including 11.5 million deaths from female reproductive cancers. The sex gap in TCALs ranged from 8.31 (95% CI, 8.28-8.34) years in Hungary to 4.22 (95% CI, 4.20-4.25) years in the Netherlands. Across all countries, females had a survival advantage for major causes of death, except for neoplasms at reproductive ages. In most populations, females aged between 35 and 60 years experienced a consistent cross-cohort excess in cancer mortality compared with males, mainly due to breast cancer and, to a lesser extent, gynecological cancers. Eliminating female reproductive cancers would increase the survival of females and expand the sex gap in TCALs by an estimated mean of 0.77 (95% CI, 0.75-0.78) years, ranging from 0.96 (95% CI, 0.92-1.00) years in Ireland to 0.51 (95% CI, 0.50-0.52) years in Japan.

Conclusions and relevance: In this population-level cohort study of 20 low-mortality countries, females aged 35 to 60 years experienced disadvantage in cancer mortality compared with males-a consistent pattern observed across birth cohorts and over time. These findings underscore the ongoing need for action on the prevention, early detection, and treatment of early-onset female reproductive cancers.

重要性:平均而言,女性比男性寿命更长。对寿命性别差异的研究传统上侧重于男性较高的死亡率;然而,女性生殖癌症对男女生存差距的影响仍然没有充分量化。目的:通过估计年龄、出生队列和死亡原因对性别生存差异的贡献来评估女性与男性的生存差距,特别强调女性生殖癌症-乳腺癌和妇科癌症-在长期寿命差异中的作用。设计、环境和参与者:本队列研究使用了人类死亡率和世界卫生组织死亡率数据库中1955年至2020年的20个国家的人口死亡率数据和完整记录。数据分析时间为2023年1月至2025年9月。暴露:地理位置(澳大利亚、奥地利、比利时、加拿大、丹麦、芬兰、法国、匈牙利、爱尔兰、意大利、日本、荷兰、新西兰、挪威、葡萄牙、西班牙、瑞典、瑞士、英国和美国)。主要结局和测量:主要结局是截短的横断面平均寿命(TCAL),它包含了在给定时间内所有出生队列的历史死亡率信息。对于每个国家,生存的性别差距——以女性和男性之间的TCAL差异来衡量——被计算、分解,并按出生队列、年龄和日历年以图形形式呈现。结果:该分析包括2.644亿人死于各种原因(1.191亿女性[45.1%];1.452亿男性[54.9%]),其中1150万人死于女性生殖肿瘤。tcal的性别差异从匈牙利的8.31 (95% CI, 8.28-8.34)年到荷兰的4.22 (95% CI, 4.20-4.25)年不等。在所有国家中,除育龄肿瘤外,女性在主要死亡原因方面具有生存优势。在大多数人群中,年龄在35岁至60岁之间的女性与男性相比,癌症死亡率在跨队列中一致高于男性,这主要是由于乳腺癌,在较小程度上是由于妇科癌症。消除女性生殖癌将增加女性的生存率,并扩大tcal的性别差距,估计平均为0.77年(95% CI, 0.75-0.78)年,从爱尔兰的0.96年(95% CI, 0.92-1.00)年到日本的0.51年(95% CI, 0.50-0.52)年。结论和相关性:在这项针对20个低死亡率国家的人口水平队列研究中,年龄在35岁至60岁之间的女性在癌症死亡率方面比男性处于劣势——这是在整个出生队列和随着时间的推移观察到的一致模式。这些发现强调了在预防、早期发现和治疗早发性女性生殖癌方面采取行动的持续必要性。
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引用次数: 0
KRAS Variant Frequency and Colorectal Cancer-Specific Survival by Race and Ethnicity. KRAS变异频率和结直肠癌特异性生存率的种族和民族。
IF 9.7 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2026-03-02 DOI: 10.1001/jamanetworkopen.2026.1585
Gladys M Rodriguez, Mayada Aljehani, Dylan DePuy, Shruti Rajesh Patel, George A Fisher, Albert Y Lin
<p><strong>Importance: </strong>Colorectal cancer is the third most commonly diagnosed cancer and the third leading cause of cancer-associated deaths in the US. Hispanic and non-Hispanic Black patients experience higher colorectal cancer mortality rates compared with non-Hispanic White patients. More data are needed to understand the role of cancer biology in colorectal cancer survival disparities among racial and ethnic minority groups.</p><p><strong>Objective: </strong>To evaluate racial and ethnic differences in KRAS variant frequency and the association of presence of a KRAS variant with colorectal cancer-specific survival.</p><p><strong>Design, setting, and participants: </strong>This population-based cross-sectional study used data from the Surveillance, Epidemiology, and End Results Program and included patients diagnosed with colorectal cancer from 2010 through 2015, with follow-up through December 31, 2018. Data were analyzed between December 2023 and August 2024.</p><p><strong>Exposure: </strong>Racial and ethnic differences in KRAS variant frequency.</p><p><strong>Main outcomes and measures: </strong>Outcomes of interest were cumulative incidence of colorectal cancer-specific death, assessed using cumulative incidence functions, and subdistribution hazard ratio (sHR) for colorectal cancer-specific death, assessed using Fine-Gray regression models.</p><p><strong>Results: </strong>A total of 21 354 patients (mean [SD] age at diagnosis, 62.54 [13.78] years; 9653 females [45.2%]; median [IQR] follow-up, 2.67 [1.25-4.17] years) were included in the analysis, including 1680 Asian or Pacific Islander patients (7.8%), 2459 Hispanic patients (11.5%), 2761 non-Hispanic Black patients (12.9%), and 14 454 non-Hispanic White patients (67.7%). Hispanic patients and non-Hispanic Black patients had higher KRAS variant frequencies than non-Hispanic Asian or Pacific Islander patients and non-Hispanic White patients (44.2% and 48.3% vs 37.5% and 39.3%, respectively). Among patients with KRAS wild-type tumors, the unadjusted cumulative incidence of colorectal cancer-specific death was highest for Hispanic patients (59.5%; 95% CI, 55.4%-63.3%; P < .001); among patients with KRAS variant tumors, colorectal cancer-specific death was highest for non-Hispanic Black patients (67.3%; 95% CI, 63.3%-70.9%; P < .001). Among patients with KRAS wild-type tumors, Hispanic patients showed a significantly increased risk of colorectal cancer-specific death (sHR, 1.11; 95% CI, 1.01-1.22; P = .03). Among patients with KRAS variant tumors, non-Hispanic Black patients had a significantly increased risk of colorectal cancer-specific death (sHR, 1.18; 95% CI, 1.07-1.29; P < .001).</p><p><strong>Conclusions and relevance: </strong>In this cross-sectional study of patients with colorectal cancer, Hispanic patients and non-Hispanic Black patients had higher KRAS variant prevalence than non-Hispanic White patients. Among patients with a KRAS variant, non-Hispanic Black patients ha
重要性:结直肠癌是美国第三大最常诊断的癌症,也是导致癌症相关死亡的第三大原因。与非西班牙裔白人患者相比,西班牙裔和非西班牙裔黑人患者的结直肠癌死亡率更高。需要更多的数据来了解癌症生物学在种族和少数民族群体中结直肠癌生存差异中的作用。目的:评估KRAS变异频率的种族和民族差异以及KRAS变异存在与结直肠癌特异性生存的关系。设计、环境和参与者:这项基于人群的横断面研究使用了来自监测、流行病学和最终结果项目的数据,包括2010年至2015年诊断为结直肠癌的患者,随访至2018年12月31日。数据分析时间为2023年12月至2024年8月。暴露:KRAS变异频率的种族和民族差异。主要结局和测量:关注的结局是结肠直肠癌特异性死亡的累积发生率,使用累积发生率函数评估,以及结肠直肠癌特异性死亡的亚分布风险比(sHR),使用Fine-Gray回归模型评估。结果:共纳入21 354例患者(诊断时平均[SD]年龄62.54[13.78]岁,女性9653例[45.2%],中位[IQR]随访2.67[1.25-4.17]年),其中亚洲或太平洋岛民1680例(7.8%),西班牙裔2459例(11.5%),非西班牙裔黑人2761例(12.9%),非西班牙裔白人14 454例(67.7%)。西班牙裔患者和非西班牙裔黑人患者的KRAS变异频率高于非西班牙裔亚裔或太平洋岛民患者和非西班牙裔白人患者(分别为44.2%和48.3% vs 37.5%和39.3%)。在KRAS野生型肿瘤患者中,未调整的结肠直肠癌特异性死亡累积发生率最高的是西班牙裔患者(59.5%;95% CI, 55.4%-63.3%; P结论和相关性:在这项结肠直肠癌患者的横断面研究中,西班牙裔患者和非西班牙裔黑人患者的KRAS变异患病率高于非西班牙裔白人患者。在KRAS变异的患者中,非西班牙裔黑人患者的病因特异性生存率比非西班牙裔白人患者差。在野生型KRAS患者中,西班牙裔患者的生存率比非西班牙裔白人患者差。这些发现强调了进一步研究kras相关结果的种族和民族差异的必要性。
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